CN209848799U - Purification device of medical intermediate - Google Patents

Abstract

The utility model discloses a purification device of medical intermediate, the mobile device comprises a main frame, main frame top is equipped with cylinder mixing arrangement, and cylinder mixing arrangement below is equipped with stirring mixing arrangement, stirring mixing arrangement below is equipped with hierarchical purification device, and is equipped with below the hierarchical purification device and connects the liquid case, cylinder mixing arrangement and stirring mixing arrangement, stirring mixing arrangement and hierarchical purification device, hierarchical purification device and connect all to be equipped with between the liquid case and separate branch, just separate and all be equipped with quick metering device on the branch. The utility model discloses at first carrying out liquid medicine hybrid processing to the liquid medicine through cylinder mixing arrangement and stirring mixing arrangement before to liquid medicine purification processing, in the liquid medicine mixed reaction back gets into hierarchical purification device through quick metering device, the impurity in the intermediate body liquid medicine is filtered and is got rid of through the hierarchical layering of adsorption plate of different density in the hierarchical purification device, improves the effect of liquid medicine purification, connects the collection liquid case at last and collects.

Description

Purification device of medical intermediate

Technical Field

The utility model relates to a purification technical field particularly, relates to a purification device of medical intermediate.

Background

The medical intermediate is some chemical raw materials or chemical products used in the process of synthesizing the medicines, and the chemical products can be produced in a common chemical plant without production licenses of the medicines and can be used for synthesizing the medicines as long as the medical intermediate reaches some grades. In the process of synthesizing a medical intermediate, a compound obtained by synthesis or extraction often needs to be separated and purified to obtain a single compound or a class of compounds with the same structure mother nucleus, the requirement of a medicine on the medicine purity is extremely high in the process of manufacturing the medicine, impurities in raw materials of the medicine need to be separated, a traditional separation mode mostly adopts a filter screen for separation, the raw materials need to be repeatedly screened by adopting the method for filtration, the time consumption is long, the effect is poor, and in view of the defects, a separation and purification device needs to be designed for improving the device. However, in the existing separation and purification device, the intermediates cannot be thoroughly mixed before being separated, and then are separated, so that the separation effect is poor, and the working efficiency is low.

An effective solution to the problems in the related art has not been proposed yet.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide a purification device of medical intermediate for solve the problem that proposes among the above-mentioned background art.

In order to achieve the above object, the utility model provides a following technical scheme: a purification device for a medical intermediate comprises a main frame, wherein a roller mixing device is arranged at the top of the main frame and consists of a fixed support rod, a driving motor I with a timing control device, a transmission gear, a transmission rod, a roller, a total liquid inlet and outlet port and a rotary mounting seat, a stirring mixing device is arranged below the roller mixing device and consists of a fixed clamping rod, a stirring cylinder, a liquid inlet, a driving motor II with a timing control device, a stirring rod with stirring blades, a fixed rotary seat, an air inlet pipe, a liquid outlet and a fan with a power supply, a grading purification device is arranged below the stirring mixing device and consists of a fixed clamping rod, a grading cylinder, a grading liquid inlet, a total grading purification cavity, a sample grading purification cavity, a grading adsorption plate and a grading liquid outlet, a liquid receiving box is arranged below the grading purification device, and separation support rods are arranged between the roller mixing device and the stirring mixing device, between the stirring mixing device and the grading purification device, and between the grading purification device and the liquid receiving box, and quick metering devices are arranged on the separation support rods and comprise fixed sleeves, telescopic pipes, quick connectors and flow control displays with power supplies.

Further, fixed branch is two sets of, and is two sets of fixed branch transversely sets up respectively on both sides wall around the main frame top and through bolt and main frame fixed connection, transfer line one end and cylinder one end fixed connection, the other end run through fixed branch and rotate with the rotatory mount pad that sets up in the fixed branch outside and be connected, driving motor I sets up on transfer line one side and fixed mounting on fixed branch, drive gear is two sets of, and is two sets of drive gear sets up respectively on driving motor I's output shaft and transfer line and the position one-to-one, and is two sets of the drive gear meshing is connected, even equidistant protruding piece that is equipped with on the cylinder inside wall, and be equipped with wavy recess on the protruding piece.

Further, the main frame all is equipped with fixed slot with the corresponding department in fixed clamping rod position, fixed clamping rod all is located fixed slot and fixed with the fixed slot joint, churn and hierarchical section of thick bamboo all overlap and establish on fixed clamping rod and fixed with fixed clamping rod joint.

Further, puddler one end is rotated with the fixed roating seat that sets up in churn inner chamber bottom and is connected, and the other end passes through the shaft coupling and sets up driving motor II fixed connection at the churn top, intake pipe one end and the fan fixed connection of setting on the main frame, the other end runs through the churn lateral wall and extends to the churn inner chamber and encircles and fix in churn inner chamber bottom, is located even equidistant air jet head that is equipped with in the intake pipe of churn inner chamber is located be equipped with the air regulating valve in the outside intake pipe of churn.

Further, total hierarchical purification chamber and sample hierarchical purification chamber all are located hierarchical section of thick bamboo inner chamber and are about being the setting, hierarchical section of thick bamboo is provided with the jack with the equal interval slant of total hierarchical purification chamber and the corresponding department of sample hierarchical purification chamber position, and is equipped with the spout in the jack, hierarchical adsorption plate be located the jack and with spout sliding connection, hierarchical inlet and hierarchical liquid outlet all are equipped with two sets ofly and the position respectively with total hierarchical purification chamber and sample hierarchical purification chamber position corresponding, the even equidistant outage that is equipped with in sample hierarchical purification chamber one side.

Further, it all is equipped with the caulking groove to separate branch and fixed sleeve and flow control display position corresponding, fixed sleeve and flow control display all are located the caulking groove, flexible pipe one end is connected with quick-operation joint, and the other end is connected with flow control display, quick-operation joint respectively with business turn over integrative total liquid mouth, inlet, liquid outlet, hierarchical inlet and hierarchical liquid outlet looks adaptation, all be equipped with the choke valve on business turn over integrative total liquid mouth, inlet, liquid outlet, hierarchical inlet and the hierarchical liquid outlet.

Furthermore, the purification device also comprises a micro water pump and a connecting pipeline which are arranged on the main frame, and the micro water pump is connected with the quick connector through the connecting pipeline.

Compared with the prior art, the utility model discloses following beneficial effect has:

(1) the utility model discloses at first carry out liquid medicine hybrid processing to the liquid medicine through cylinder mixing arrangement and stirring mixing arrangement before to liquid medicine purification processing, in the liquid medicine mixed reaction back gets into hierarchical purification device through quick metering device, the impurity filtration in the intermediate body liquid medicine is got rid of through the hierarchical layering of adsorption plate of different density in the hierarchical purification device, improves the effect of liquid medicine purification, connects the collection liquid case at last and collects.

(2) The cylinder design is convenient for mix the liquid medicine and improves mobility under the effect of gravity, makes and mixes the liquid medicine and can carry out high-speed impact and disperse other places inside the cylinder to the wavy recess on the inside protruding piece of cylinder when the cylinder operates, plays preliminary mixing effect.

(3) The design of the stirring rod is convenient for carrying out secondary mixing on mixed liquid medicine in the stirring barrel, and when the stirring blades are mechanically stirred, gas is added into the inner cavity of the stirring barrel through the air inlet pipe, so that the mixing efficiency is improved.

(4) Be equipped with total hierarchical purification chamber and the hierarchical purification chamber of sample in the hierarchical section of thick bamboo, the impartial interval slant of intracavity is equipped with hierarchical adsorption plate, and pull formula convenient to use and clearance are equipped with the outage simultaneously in sample hierarchical purification chamber one side, and the accessible outage is discharged the liquid medicine in the different hierarchical adsorption plate region, if the sample is unqualified, and accessible micro water pump, connecting tube and quick-operation joint cooperate and carry the liquid medicine to mix in the cylinder once more.

(5) The quick connector, the throttle valve and the flow control display are designed to facilitate connection and quantitative acquisition of products, and the using effect is good.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required to be used in the embodiments will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.

Fig. 1 is a schematic structural diagram of a device for purifying a pharmaceutical intermediate according to an embodiment of the present invention;

fig. 2 is a schematic structural diagram of a drum mixing device in a pharmaceutical intermediate purification device according to an embodiment of the present invention;

fig. 3 is a schematic structural diagram of a stirring and mixing device in a pharmaceutical intermediate purification device according to an embodiment of the present invention;

fig. 4 is a schematic structural diagram of a graded purification device in a purification device for pharmaceutical intermediates according to an embodiment of the present invention;

fig. 5 is a schematic structural diagram of a rapid metering device in a purification device for pharmaceutical intermediates according to an embodiment of the present invention;

fig. 6 is a schematic structural diagram of a bump in a purification apparatus for pharmaceutical intermediates according to an embodiment of the present invention.

Reference numerals:

the device for purifying the medical intermediate is characterized by comprising a main frame 1; 2. a drum mixing device; 21. fixing the supporting rod; 22. driving a motor I; 23. a transmission gear; 24. a transmission rod; 25. A drum; 26. an inlet and outlet integrated main liquid port; 27. rotating the mounting seat; 3. a stirring and mixing device; 31. fixing the clamping rod; 32. a mixing drum; 33. a liquid inlet; 34. driving a motor II; 35. a stirring rod; 36. fixing the rotating seat; 37. an air inlet pipe; 38. a liquid outlet; 39. a fan; 4. a classification and purification device; 41. fixing the clamping rod; 42. a grading cylinder; 43. a grading liquid inlet; 44. a total fractionation purification chamber; 45. a sample grading and purifying cavity; 46. a graded adsorption plate; 47. a grading liquid outlet; 5. a liquid receiving box; 6. a separation strut; 7. a fast metering device; 71. fixing the sleeve; 72. a telescopic pipe; 73. a quick coupling; 74. a flow control display; 100. and (4) a convex block.

Detailed Description

The following, with reference to the drawings and the detailed description, further description of the present invention is made:

referring to fig. 1-6, a device for purifying a pharmaceutical intermediate according to an embodiment of the present invention includes a main frame 1, a drum mixing device 2 is disposed on a top of the main frame 1, the drum mixing device 2 is composed of a fixed support rod 21, a driving motor I22 with a timing control device, a transmission gear 23, a transmission rod 24, a drum 25, a total liquid inlet/outlet 26 with a timing control device, and a rotary mounting seat 27, a stirring and mixing device 3 is disposed under the drum mixing device 2, the stirring and mixing device 3 is composed of a fixed clamping rod 31, a stirring cylinder 32, a liquid inlet 33, a driving motor II34 with a timing control device, a stirring rod 35 with stirring blades, a fixed rotary seat 36, an air inlet pipe 37, a liquid outlet 38, and a fan 39 with a power supply, a grading and purifying device 4 is disposed under the stirring and mixing device 3, hierarchical purification device 4 comprises fixing clamping rod 31, a hierarchical section of thick bamboo 42, hierarchical inlet 43, total hierarchical purification chamber 44, the hierarchical purification chamber 45 of sample, hierarchical adsorption plate 46 and hierarchical liquid outlet 47, hierarchical purification device 4 below is equipped with connects liquid case 5, cylinder mixing arrangement 2 and stirring mixing arrangement 3, stirring mixing arrangement 3 and hierarchical purification device 4, hierarchical purification device 4 and connect and all be equipped with between the liquid case 5 and separate branch 6, and separate and all be equipped with quick metering device 7 on the branch 6, quick metering device 7 comprises fixed sleeving 71, flexible pipe 72, quick-operation joint 73 and the flow control display 74 from the electrified source.

Wherein, the fixed supporting rods 21 are two groups, two groups of the fixed supporting rods 21 are respectively transversely arranged on the front and rear side walls of the top end of the main frame 1 and are fixedly connected with the main frame 1 through bolts, one end of the transmission rod 24 is fixedly connected with one end of the roller 25, the other end of the transmission rod passes through the fixed supporting rods 21 and is rotatably connected with the rotary mounting seat 27 arranged outside the fixed supporting rods 21, the driving motor I22 is arranged on one side of the transmission rod 24 and is fixedly arranged on the fixed supporting rods 21, the two groups of the transmission gears 23 are respectively arranged on the output shaft of the driving motor I22 and the transmission rod 24 and are in one-to-one correspondence in position, the two groups of the transmission gears 23 are meshed and connected, the convex blocks 100 are uniformly arranged on the inner side wall of the roller 25 at equal intervals, the wavy grooves are arranged on the convex blocks 100, the fixing clamping rod 31 is positioned in the fixing clamping groove and is fixed with the fixing clamping groove in a clamping manner, the mixing drum 32 and the grading drum 42 are sleeved on the fixing clamping rod 31 and are fixed with the fixing clamping rod 31 in a clamping manner, one end of the mixing drum 35 is rotatably connected with a fixed rotary seat 36 arranged at the bottom of an inner cavity of the mixing drum 32, the other end of the mixing drum is fixedly connected with a driving motor II34 arranged at the top of the mixing drum 32 through a coupler, one end of an air inlet pipe 37 is fixedly connected with a fan 39 arranged on the main frame 1, the other end of the air inlet pipe penetrates through the side wall of the mixing drum 32, extends to the inner cavity of the mixing drum 32 and is fixed at the bottom of the inner cavity of the mixing drum 32 in a surrounding manner, air nozzles are uniformly arranged at equal intervals in the air inlet pipe 37 in the inner cavity of the mixing drum 32, an air regulating valve is arranged in the air inlet pipe 37, the classifying cylinder 42 is obliquely provided with jacks at equal intervals corresponding to the positions of the total classification and purification cavity 44 and the sample classification and purification cavity 45, sliding grooves are formed in the jacks, the classification adsorption plate 46 is positioned in the jacks and is in sliding connection with the sliding grooves, the classification liquid inlet 43 and the classification liquid outlet 47 are both provided with two groups of cavities and the positions of the cavities are respectively corresponding to the positions of the total classification and purification cavity 44 and the sample classification and purification cavity 45, liquid drainage holes are uniformly and equidistantly formed in one side of the sample classification and purification cavity 45, caulking grooves are correspondingly formed in the positions of the separation support rod 6, the fixed sleeve 71 and the flow control display 74, one end of the telescopic pipe 72 is connected with the quick connector 73, the other end of the telescopic pipe is connected with the flow control display 74, and the quick connector 73 is respectively connected with the total liquid inlet 26, the liquid inlet 33, the total liquid inlet 33, Liquid outlet 38, hierarchical inlet 43 and hierarchical liquid outlet 47 looks adaptation, all be equipped with the choke valve on business turn over integrative total liquid mouth 26, inlet 33, liquid outlet 38, hierarchical inlet 43 and the hierarchical liquid outlet 47, this purification device is still including setting up miniature pump and the connecting tube on main frame 1, miniature pump passes through the connecting tube and is connected with quick-operation joint 73.

The working principle is as follows: in the utility model, before the liquid medicine purification treatment, firstly, the liquid medicine is mixed and treated through the roller mixing device 2 and the stirring mixing device 3, the liquid medicine is mixed and reacted and then enters the stage purification device 4 through the rapid metering device 7, impurities in the intermediate liquid medicine are filtered and removed through the stage adsorption plates 46 with different densities in the stage purification device 4 in a stage-by-stage mode, the liquid medicine purification effect is improved, and finally, the liquid collection box 5 is connected for collection, wherein, the roller 25 is designed to facilitate the improvement of the fluidity of the mixed liquid medicine under the action of gravity, so that the mixed liquid medicine can impact the wavy groove on the convex block 100 in the roller 25 at high speed and disperse to other places in the roller 25 when the roller 25 runs, the preliminary mixing effect is achieved, the stirring rod 35 is designed to facilitate the secondary mixing of the mixed liquid medicine in the stirring cylinder 32, when the stirring blade is mechanically stirred, add gas to the inner chamber of the mixing drum 32 through the intake pipe 37, the mixing efficiency is improved, be equipped with total hierarchical purification chamber 44 and sample hierarchical purification chamber 45 in the hierarchical section of thick bamboo 42, the impartial interval slant of intracavity is equipped with hierarchical adsorption plate 46, pull formula convenient to use and clearance, be equipped with the outage in 48 one side in the hierarchical purification chamber of sample simultaneously, the liquid medicine in the different hierarchical adsorption plate 46 regions of accessible outage is discharged, if the sample is unqualified, accessible micro water pump, connecting tube and quick-operation joint 73 cooperate and carry the liquid medicine once more in the cylinder 25 remixing, quick-operation joint 73, choke valve and flow control display 74 design are convenient for connect and the ration obtains the product, excellent in use effect.

Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims (7)

1. A purification device of a medical intermediate is characterized by comprising a main frame (1), wherein a roller mixing device (2) is arranged at the top of the main frame (1), the roller mixing device (2) is composed of a fixed support rod (21), a driving motor I (22) with a timing control device, a transmission gear (23), a transmission rod (24), a roller (25), an integrated inlet and outlet total liquid port (26) and a rotary mounting seat (27), a stirring mixing device (3) is arranged below the roller mixing device (2), the stirring mixing device (3) is composed of a fixed clamping rod (31), a stirring cylinder (32), a liquid inlet (33), a driving motor II (34) with a timing control device, a stirring rod (35) with stirring blades, a fixed rotating seat (36), an air inlet pipe (37), a liquid outlet (38) and a fan (39) with a power supply, a grading purification device (4) is arranged below the stirring and mixing device (3), the grading purification device (4) consists of a fixed clamping rod (31), a grading cylinder (42), a grading liquid inlet (43), a total grading purification cavity (44), a sample grading purification cavity (45), a grading adsorption plate (46) and a grading liquid outlet (47), a liquid receiving box (5) is arranged below the grading and purifying device (4), separating support rods (6) are respectively arranged between the roller mixing device (2) and the stirring and mixing device (3), between the stirring and mixing device (3) and the grading and purifying device (4) and between the grading and purifying device (4) and the liquid receiving box (5), and the separation support rods (6) are respectively provided with a quick metering device (7), and the quick metering devices (7) consist of a fixed sleeve (71), an extension pipe (72), a quick connector (73) and a flow control display (74) with a power supply.

2. The device for purifying a pharmaceutical intermediate as claimed in claim 1, wherein the fixed support bars (21) are provided in two groups, the two groups of fixed support bars (21) are transversely disposed on the front and rear side walls of the top end of the main frame (1) respectively and are fixedly connected to the main frame (1) through bolts, one end of the transmission rod (24) is fixedly connected to one end of the roller (25), the other end of the transmission rod penetrates through the fixed support bars (21) and is rotatably connected to a rotary mounting seat (27) disposed outside the fixed support bars (21), the driving motor I (22) is disposed on one side of the transmission rod (24) and is fixedly mounted on the fixed support bars (21), the two groups of transmission gears (23) are provided in two groups, the two groups of transmission gears (23) are disposed on the output shaft of the driving motor I (22) and the transmission rod (24) respectively and are in one-to-one correspondence positions, the drum is characterized in that the inner side wall of the drum (25) is uniformly provided with protruding blocks (100) at equal intervals, and the protruding blocks (100) are provided with wavy grooves.

3. The purification device for pharmaceutical intermediates according to claim 1, wherein the main frame (1) is provided with a fixing clip groove at a position corresponding to the fixing clip rod (31), the fixing clip rod (31) is located in the fixing clip groove and fixed with the fixing clip groove in a clamping manner, and the stirring cylinder (32) and the classifying cylinder (42) are sleeved on the fixing clip rod (31) and fixed with the fixing clip rod (31) in a clamping manner.

4. The device for purifying a pharmaceutical intermediate as claimed in claim 1, wherein one end of the stirring rod (35) is rotatably connected with a fixed rotating seat (36) arranged at the bottom of the inner cavity of the stirring cylinder (32), the other end of the stirring rod is fixedly connected with a driving motor II (34) arranged at the top of the stirring cylinder (32) through a coupling, one end of the air inlet pipe (37) is fixedly connected with a fan (39) arranged on the main frame (1), the other end of the air inlet pipe penetrates through the side wall of the stirring cylinder (32) and extends to the inner cavity of the stirring cylinder (32) and is fixed at the bottom of the inner cavity of the stirring cylinder (32) in a surrounding manner, air nozzles are uniformly arranged on the air inlet pipe (37) arranged in the inner cavity of the stirring cylinder (32) at equal intervals, and an air regulating valve is arranged on the air inlet.

5. The device for purifying a pharmaceutical intermediate as claimed in claim 1, wherein the total classification purification chamber (44) and the sample classification purification chamber (45) are both located in the inner cavity of the classification cylinder (42) and are arranged in a left-right manner, the classification cylinder (42) is obliquely provided with insertion holes at equal intervals at positions corresponding to the total classification purification chamber (44) and the sample classification purification chamber (45), sliding grooves are arranged in the insertion holes, the classification adsorption plate (46) is located in the insertion holes and is slidably connected with the sliding grooves, the classification liquid inlet (43) and the classification liquid outlet (47) are both provided with two groups of liquid outlets at positions corresponding to the total classification purification chamber (44) and the sample classification purification chamber (45), and liquid discharge holes are uniformly arranged at equal intervals on one side of the sample classification purification chamber (45).

6. A device for purifying a pharmaceutical intermediate as claimed in claim 1, wherein the separation rod (6) is provided with a caulking groove corresponding to the position of the fixing sleeve (71) and the position of the flow control display (74), the fixing sleeve (71) and the flow control display (74) are both located in the caulking groove, one end of the telescopic tube (72) is connected with the quick connector (73), the other end of the telescopic tube is connected with the flow control display (74), the quick connector (73) is respectively matched with the total liquid inlet and outlet (26), the liquid inlet (33), the liquid outlet (38), the grading liquid inlet (43) and the grading liquid outlet (47), and the total liquid inlet and outlet (26), the liquid inlet (33), the liquid outlet (38), the grading liquid inlet (43) and the grading liquid outlet (47) are provided with a throttle valve.

7. The purification device for pharmaceutical intermediates of claim 1, further comprising a micro-pump and a connection pipe arranged on the main frame (1), wherein the micro-pump is connected with the quick connector (73) through the connection pipe.