CN209778710U - Constant-temperature magnetic stirring device for antibody coupling - Google Patents
Constant-temperature magnetic stirring device for antibody coupling Download PDFInfo
- Publication number
- CN209778710U CN209778710U CN201920363756.0U CN201920363756U CN209778710U CN 209778710 U CN209778710 U CN 209778710U CN 201920363756 U CN201920363756 U CN 201920363756U CN 209778710 U CN209778710 U CN 209778710U
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- Prior art keywords
- magnetic stirring
- temperature
- bolt
- module
- water
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- Expired - Fee Related
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- 238000003760 magnetic stirring Methods 0.000 title claims abstract description 54
- 238000010168 coupling process Methods 0.000 title claims abstract description 20
- 230000008878 coupling Effects 0.000 title claims abstract description 19
- 238000005859 coupling reaction Methods 0.000 title claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 72
- 238000010438 heat treatment Methods 0.000 claims abstract description 46
- 238000006243 chemical reaction Methods 0.000 claims abstract description 28
- 238000003756 stirring Methods 0.000 claims abstract description 15
- 238000004321 preservation Methods 0.000 claims abstract description 10
- 239000000523 sample Substances 0.000 claims description 12
- 238000012544 monitoring process Methods 0.000 claims description 5
- 230000002093 peripheral effect Effects 0.000 claims description 3
- 238000005842 biochemical reaction Methods 0.000 abstract description 5
- 238000007667 floating Methods 0.000 description 2
- 239000008236 heating water Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000009413 insulation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
Landscapes
- Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
The utility model discloses a can be used to antibody coupling's constant temperature magnetic stirring device, include: the device comprises a magnetic stirring module, a water bath, a water circulation heating module, a transparent heat preservation cover and a plurality of groups of reaction bottle fixing modules, wherein the water bath is placed on the magnetic stirring module; the magnetic stirring module and the water bath tank and the transparent heat-insulating cover are fixed by fast clamping. The utility model discloses an accurate temperature control, reaction solution stirring and heat retaining biochemical reaction unit can be used to the antibody coupling.
Description
Technical Field
The utility model relates to an experimental apparatus, concretely relates to constant temperature magnetic stirring device that can be used to antibody coupling.
Background
at present, no suitable biochemical reaction device for antibody coupling is available on the market, and the biochemical reaction device is generally carried out in an open water bath. The existing water bath kettle has high requirement on working water level and poor temperature uniformity. The utility model provides a biochemical reaction device which integrates accurate temperature control, reaction solution stirring and heat preservation and can be used for antibody coupling.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing a constant temperature magnetic stirring device that can be used to antibody coupling to solve prior art not enough.
The utility model adopts the following technical scheme:
A constant temperature magnetic stirring device useful for antibody coupling, comprising: the device comprises a magnetic stirring module, a water bath, a water circulation heating module, a transparent heat preservation cover and a plurality of groups of reaction bottle fixing modules, wherein the water bath is placed on the magnetic stirring module; the magnetic stirring module and the water bath tank and the transparent heat-insulating cover are fixed by fast clamping.
Further, the magnetic stirring module includes bearing panel from last to down in proper order, multiunit magnetic stirring motor, the bottom plate, control unit and display element establish on the curb plate, control unit includes control switch and multiunit speed control button, control switch and the opening of multiunit magnetic stirring motor electric connection control magnetic stirring motor, speed control button and the corresponding magnetic stirring motor connection control correspond magnetic stirring motor's rotational speed, display element shows whether multiunit magnetic stirring motor opens and the rotational speed.
Further, the water bath may be changed to a water bath of a different size according to the scale of the reaction.
Furthermore, the water circulation heating module comprises a water circulation heating module main body, a multi-layer heating pipe, a temperature-sensing probe and a stirring paddle, the multi-layer heating pipe, the temperature-sensing probe and the stirring paddle are arranged in the water circulation heating module main body and are electrically connected with the water circulation heating module main body, a plurality of small holes are formed in the peripheral wall of the water circulation heating module main body, a control and display part is arranged at the top of the water circulation heating module main body, the control part comprises two switches, one switch is used for controlling stirring, and the other switch is used for controlling heating; the temperature sensing probe is used for monitoring the water temperature, monitoring information is processed in the main body, and then the multi-level heating pipe is controlled to work through the main body; the display part displays the temperature monitored by the temperature sensing probe.
Furthermore, the transparent heat-insulating cover is provided with a plurality of groups of openings, the reaction bottle fixing module comprises a fixing rod, a stress component, a rotating rod and a combining component, a threaded hole is formed in the upper portion of the fixing rod, an external thread is formed in the middle lower portion of the fixing rod, the stress component is fixed at the bottom end of the fixing rod, the combining component comprises a bolt and a nut, the bolt is hollow, and an internal thread is formed in the inner wall of the bolt and matched with the external thread; the bolt is worn out from the opening on the transparent heat preservation cover, and is fixed with the nut, and the dead lever top is worn out by supreme down in the middle of the bolt, dead lever and bolt threaded connection, and during the screw hole of dead lever was inserted to the rotary rod, rotatory rotary rod drove the dead lever and reciprocated in the bolt to adjust the atress part and the reaction flask distance.
The utility model has the advantages that:
the utility model provides a collect accurate temperature control, reaction solution stirring and heat retaining biochemical reaction unit, can be used to the antibody coupling:
1. The utility model discloses utilize hydrologic cycle heating module to heat the heat preservation to the water in the water bath, the homogeneity of the incessant stirring of stirring simultaneously in order to ensure water bath temperature provides suitable temperature environment for antibody coupling technology. The heater block of hydrologic cycle heating module is the multilevel heating pipe, and low water level, high water level all can work, carries out the heating to different water levels through the heating pipe of control co-altitude, only uses the lowest heating pipe to heat water during the low water level, and the accessible uses many heating pipes to realize the rapid heating to water during the high water level.
2. The utility model discloses a magnetic stirring module provides power for the magnetic stirrer in the reaction flask, promotes the mixture of liquid in the reaction flask.
3. The transparent heat preservation cover of the utility model is beneficial to keeping the water temperature in the water bath, reducing the temperature fluctuation caused by the external environment change and improving the coupling efficiency; on the other hand, the reaction bottle fixing module arranged at the top is used for pressing and fixing the reaction bottle in the water tank so as to avoid overturning and floating.
4. the water bath tank of the utility model is replaceable and is suitable for coupling processes of different scales.
5. The utility model discloses between magnetic stirring module and the water bath, fixed all is fixed through quick clamping between water bath and the transparent heat preservation cover, the dismouting of being convenient for.
Drawings
Fig. 1 is a schematic structural diagram of the present invention.
Fig. 2 is a schematic view of the present invention.
FIG. 3 is a schematic disassembled view of the magnetic stirring module.
FIG. 4 is a schematic drawing showing the water circulating heating module disassembled.
FIG. 5 is a schematic view of a reaction vial retaining module.
FIG. 6 is a schematic view of a quick-mount clip.
FIG. 7 is a schematic view of a coupling portion of the quick clip.
Detailed Description
The invention is further explained below with reference to examples and figures. The following examples are provided only for illustrating the present invention and are not intended to limit the scope of the present invention.
An isothermal magnetic stirring device useful for antibody coupling, as shown in fig. 1 and 2, comprising: the device comprises a magnetic stirring module 5, a water bath 3, a water circulation heating module 6, a transparent heat-preservation cover 2 and a plurality of groups of reaction bottle fixing modules 1.
The magnetic stirring module 5 provides stirring power for the solution in the reaction bottle, and as shown in fig. 3, the magnetic stirring module sequentially comprises a bearing panel 5-1, a plurality of groups of magnetic stirring motors 5-2 and a bottom plate 5-3 from top to bottom, a control part and a display part 5-6 are arranged on a side plate, the control part comprises a control switch 5-4 and a plurality of groups of rotating speed control buttons 5-5, the control switch 5-4 is electrically connected with the plurality of groups of magnetic stirring motors 5-2 to control the opening of the magnetic stirring motors 5-2, the rotating speed control buttons 5-5 are connected with the corresponding magnetic stirring motors 5-2 to control the rotating speed of the corresponding magnetic stirring motors 5-2, and the display part 5-6 displays whether the plurality of groups of magnetic stirring motors 5-2 are opened or.
The size and the depth of the water bath 3 can be changed according to the reaction scale, and the maximum bottom area of the water bath 3 is not more than the area of the bearing panel 5-1 of the magnetic stirring module 5.
The water circulation heating module 6 can work at both low water level and high water level, the circulating water ensures uniform temperature, as shown in figure 4, the water circulation heating module comprises a water circulation heating module main body 6-1, a multi-layer heating pipe 6-2, a temperature sensing probe 6-3, a stirring paddle 6-4, the multi-layer heating pipe 6-2, the temperature sensing probe 6-3 and the stirring paddle 6-4, which are arranged in the water circulation heating module main body 6-1 and electrically connected with the water circulation heating module main body 6-1, a plurality of small holes are arranged on the peripheral wall of the water circulation heating module main body 6-1, a control and display part is arranged at the top, the control part comprises two switches, one is used for controlling stirring, the other is used for controlling heating, the temperature is monitored through the temperature sensing probe 6-3, and monitoring information is processed in the main body 6-1, then, the multi-level heating pipe 6-2 is controlled to work through the main body 6-1, only the lowest heating pipe is used for heating water at a low water level, and three heating pipes are used for quickly heating water at a high water level; the display part displays the temperature measured by the temperature-sensing probe 6-3.
The transparent heat-insulating cover 2 is used for insulating heat and reducing the interference of external temperature change and is provided with a plurality of groups of openings; the reaction flask fixing module 1 is used for fixing a reaction flask and preventing the reaction flask from turning over and floating, the position of the reaction flask fixing module 1 corresponds to the position of a magnetic stirring motor 5-2 in the magnetic stirring module 5, and as shown in fig. 5, the reaction flask fixing module comprises a fixing rod 1-1, a stress component 1-2, a rotating rod 1-3 and a combining component 1-4, the upper part of the fixing rod 1-1 is provided with a threaded hole, the middle lower part of the fixing rod is provided with an external thread, the stress component 1-2 is fixed at the bottom end of the fixing rod 1-1, the combining component 1-4 comprises a bolt and a nut, the bolt is hollow, and the inner wall of the bolt is provided with; the bolt penetrates out of an opening in the transparent heat-insulation cover 2 and is fixed by a nut, the top end of the fixing rod 1-1 penetrates out of the middle of the bolt from bottom to top, the fixing rod 1-1 is in threaded connection with the bolt, the rotating rod 1-3 is inserted into a threaded hole of the fixing rod 1-1, and the rotating rod 1-3 is rotated to drive the fixing rod 1-1 to move up and down in the bolt, so that the distance between the stress component 1-2 and the reaction bottle is adjusted.
The water bath 3 is placed on the magnetic stirring module 5, the water circulation heating module 6 is placed in the water bath 3, the reaction bottle is placed in the water bath 3, the placing position corresponds to the positions of the stress part 1-2 and the magnetic stirring motor 5-2, and the transparent heat-insulating cover 2 is placed on the water bath 3. The magnetic stirring module 5 and the water bath 3, and the water bath 3 and the transparent heat-insulating cover 2 are fixed by the quick clamps 4, the structure of the quick clamps is shown in figure 6, and the structure of the joint part of the quick clamps is shown in figure 7. The rotary rod 1-3 is rotated to adjust the height of the fixed rod 1-1 until the stress component 1-2 is tightly contacted with the reaction bottle.
Claims (5)
1. A thermostatic magnetic stirring device for antibody coupling, comprising: the device comprises a magnetic stirring module, a water bath, a water circulation heating module, a transparent heat preservation cover and a plurality of groups of reaction bottle fixing modules, wherein the water bath is placed on the magnetic stirring module; the magnetic stirring module and the water bath tank and the transparent heat-insulating cover are fixed by fast clamping.
2. The constant-temperature magnetic stirring device for antibody coupling according to claim 1, wherein the magnetic stirring module comprises a bearing panel, a plurality of sets of magnetic stirring motors, and a bottom plate in sequence from top to bottom, the control part and the display part are arranged on the side plates, the control part comprises a control switch and a plurality of sets of rotation speed control buttons, the control switch and the plurality of sets of magnetic stirring motors are electrically connected to control the turning on of the magnetic stirring motors, the rotation speed control buttons and the corresponding magnetic stirring motors are connected to control the rotation speeds of the corresponding magnetic stirring motors, and the display part displays whether the plurality of sets of magnetic stirring motors are turned on and the rotation speeds of the corresponding magnetic stirring motors.
3. The isothermal magnetic stirring device for antibody coupling according to claim 1, wherein the water bath is replaceable with water baths of different sizes according to reaction scale.
4. The constant-temperature magnetic stirring device for antibody coupling according to claim 1, wherein the water circulation heating module comprises a water circulation heating module body, a multi-level heating pipe, a temperature-sensitive probe and a stirring paddle, the multi-level heating pipe, the temperature-sensitive probe and the stirring paddle are arranged in the water circulation heating module body and are electrically connected with the water circulation heating module body, a plurality of small holes are formed in the peripheral wall of the water circulation heating module body, a control and display part is arranged at the top of the water circulation heating module body, the control part comprises two switches, one switch is used for controlling stirring, and the other switch is used for controlling heating; the temperature sensing probe is used for monitoring the water temperature, monitoring information is processed in the main body, and then the multi-level heating pipe is controlled to work through the main body; the display part displays the temperature monitored by the temperature sensing probe.
5. The constant-temperature magnetic stirring device for antibody coupling according to claim 1, wherein the transparent heat-insulating cover is provided with a plurality of groups of openings, the reaction flask fixing module comprises a fixing rod, a force-bearing component, a rotating rod and a combining component, the upper part of the fixing rod is provided with a threaded hole, the middle lower part of the fixing rod is provided with an external thread, the force-bearing component is fixed at the bottom end of the fixing rod, the combining component comprises a bolt and a nut, the bolt is hollow, and the inner wall of the bolt is provided with an internal thread matched with the external thread; the bolt is worn out from the opening on the transparent heat preservation cover, and is fixed with the nut, and the dead lever top is worn out by supreme down in the middle of the bolt, dead lever and bolt threaded connection, and during the screw hole of dead lever was inserted to the rotary rod, rotatory rotary rod drove the dead lever and reciprocated in the bolt to adjust the atress part and the reaction flask distance.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920363756.0U CN209778710U (en) | 2019-03-21 | 2019-03-21 | Constant-temperature magnetic stirring device for antibody coupling |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920363756.0U CN209778710U (en) | 2019-03-21 | 2019-03-21 | Constant-temperature magnetic stirring device for antibody coupling |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209778710U true CN209778710U (en) | 2019-12-13 |
Family
ID=68799095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920363756.0U Expired - Fee Related CN209778710U (en) | 2019-03-21 | 2019-03-21 | Constant-temperature magnetic stirring device for antibody coupling |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN209778710U (en) |
-
2019
- 2019-03-21 CN CN201920363756.0U patent/CN209778710U/en not_active Expired - Fee Related
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| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20191213 |
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| CF01 | Termination of patent right due to non-payment of annual fee |