CN209712839U - Conduit device is peeped in one kind - Google Patents

Abstract

This application discloses conduit device, including casing and interior snooping head is peeped in one kind, useful optical fiber and signal wire in connection imaging device is accommodated in described sleeve pipe；The end of described sleeve pipe is arranged in the interior snooping head, including optical focus module and ultrasonic transducer, the optical focus module are connect with the optical fiber, and the ultrasonic transducer is connect with the signal wire.Since optical focus module therein can carry out optical signalling acquisition to the sample tissue of pancreatic duct, ultrasonic transducer then can carry out ultrasonic signal acquisition to the sample tissue, it can be realized the primary medical imaging for importing and realizing multiple modalities, so as to considerably reduce by the pain for the person of examining.

Description

Conduit device is peeped in one kind

Technical field

This application involves the field of medical instrument technology, more specifically to peeping conduit device in one kind.

Background technique

Pancreas is the big body of gland that liver is only second in human body, and ductus pancreaticus and bile duct Common openings are in major duodenal papilla, pancreas The bile that the pancreatic juice and liver of secretion generate flows to duodenum by this opening and participates in food digestion.However, pancreas gallbladder one Malignant change occurs for denier, often with having the characteristics that incidence of occult, progress fast, high recurrence rate, transfer are early.Since pancreas gallbladder position is deeper, At present for the early diagnosis of such lesion early control it is extremely difficult [S.Rizvi, G.J.Gores, Pathogenesis, diagnosis, and management of cholangio carcinoma,Gastroenterology 145(6)(2013)1215-29.]。

Currently, lacking efficient method of early diagnosis and effective molecular marking technique, the pancreas disorder of gallbladder to pancreas gallbladder malignant tumour Become mechanism to be still not clear.The majority clinically made a definite diagnosis has been middle and advanced stage patient, poor prognosis, 5 years survival rates of patient after treatment It is below 5%.Cancer of pancreas is more known as " king of cancer " [R.L.Siegel, K.D.Miller, A.Jemal, Cancer Statistics,2017,CA:a cancer journal for clinicians 67(1)(2017)7-30。 E.R.Witkowski,J.K.Smith,J.F.Tseng,Outcomes following resection of pancreatic cancer,Journalof surgical oncology 107(1)(2013)97-103].Therefore, research and development have it is highly sensitive, The method and instrument of the early stage diagnosis and treatment of high specific and clinical applicability are the prospective need of pancreatic duct cancer diagnosis and treatment.

Present inventor has found that pancreatic duct malignant change often originates from the endothelial cell of ductus pancreaticus or bile duct under study for action. It is generally formed a dynamic process: pancreatic duct epithelial cell dysplasia is manifested initially by, further to pancreatic duct substrate Film infiltration growth, development is adenocarcinoma infiltrating after breaking through basilar memebrane.In this course, the typical tissue morphology of pancreatic duct epithelium It learns to change and is mainly reflected in exception of both structure and cytology.Extremely normal pancreatic duct epithelium is criticized in structure by marshalling Simple cuboidal or low columnar epithelium is gradually replaced rich in the high column cell of mucus cytoplasm, occur epithelial cell arrange it is disorderly Disorderly lost with normal cell polarity；Cytological abnormal refers to that nucleus is irregular, and chromatin contaminates deeply, and nucleus is not of uniform size, caryoplasm Ratio increases to be increased with nuclear fission activity.When the cell of dysplasia continues to increase, breakthrough basilar memebrane is infiltrated into parenchymatous disease Just development is the duct adenocarcinoma with deep invasion.

In conclusion carrying out accurate judgement to the morphological abnormalities of the pancreatic duct in this stage is that pancreatic duct malignant tumour is faced The important references of bed diagnosis and treatment.For this reason, it may be necessary to pancreatic duct is effectively imaged, so that doctor can be according to generated medicine shadow As simultaneously integrative medicine knowledge judges the disease.It is all to utilize single mode at present when carrying out based endoscopic imaging to pancreas Imaging method, if necessary to carry out multi-modality imaging need repeatedly insertion it is corresponding in peeps conduit and cooperates different equipment It is able to achieve, to increase by the pain for the person of examining.

Utility model content

In view of this, the application, which provides, peeps conduit device in one kind, for carrying out medical imaging to pancreatic duct, enable the clinician to Enough according to Multimodal medical image and the corresponding medical knowledge of combination, to pancreatic duct, whether canceration judges, to mitigate by the person's of examining Pain.

To achieve the goals above, it is proposed that scheme it is as follows:

Conduit device, including casing and interior snooping head are peeped in one kind, in which:

Useful optical fiber and signal wire in connection imaging device is accommodated in described sleeve pipe；

The end of described sleeve pipe, including optical focus module and ultrasonic transducer, the light is arranged in the interior snooping head It learns focus module to connect with the optical fiber, the ultrasonic transducer is connect with the signal wire.

Optionally, the optical focus module includes hemispheric light transmission ball, in which:

A part of the light transmission ball is connect with the optical fiber；

Gold-plated reflectance coating is provided in the horizontal bottom of the light transmission ball.

Optionally, the direction of the launch of the optical focus module mutually deviates from the direction of the launch of the ultrasonic transducer.

It optionally, further include setting flag ring, the Marking ring is arranged in the end.

It optionally, further include photoelectricity slip ring assembly, one end of the photoelectricity slip ring assembly is used to believe with the imaging device Number connection, the other end are used to connect with the optical focus module by signal, by the signal wire and the ultrasound by optical fiber Transducer signal connection.

Optionally, the photoelectricity slip ring assembly includes rotary photoelectric coupling unit and for driving the rotary photoelectric The rotary drive motor of coupling unit rotation.

It can be seen from the above technical scheme that this application discloses the multi-mode imaging systems of a kind of pancreatic duct and its interior Conduit device, including casing and interior snooping head are peeped, useful optical fiber and signal wire in connection imaging device is accommodated in described sleeve pipe； The end of described sleeve pipe, including optical focus module and ultrasonic transducer, the optical focus mould is arranged in the interior snooping head Block is connect with the optical fiber, and the ultrasonic transducer is connect with the signal wire.Since optical focus module therein can be right The sample tissue of pancreatic duct carries out optical signalling acquisition, and ultrasonic transducer then can carry out ultrasonic signal to the sample tissue and adopt Collection can be realized the primary medical imaging for importing and realizing multiple modalities, so as to considerably reduce by the pain for the person of examining.

Detailed description of the invention

In order to illustrate the technical solutions in the embodiments of the present application or in the prior art more clearly, to embodiment or will show below There is attached drawing needed in technical description to be briefly described, it should be apparent that, the accompanying drawings in the following description is only this Some embodiments of application for those of ordinary skill in the art without creative efforts, can be with It obtains other drawings based on these drawings.

Fig. 1 is the structural schematic diagram that conduit device is peeped in one kind provided by the embodiments of the present application；

Fig. 2 is the structural schematic diagram that conduit device is peeped in another kind provided by the embodiments of the present application；

Fig. 3 is the structural schematic diagram provided by the embodiments of the present application that conduit device is peeped in another；

Fig. 4 is the block diagram for applying for a kind of multi-mode imaging system of pancreatic duct of embodiment；

Fig. 5 is the block diagram for applying for the multi-mode imaging system of another pancreatic duct of embodiment；

Fig. 6 is image obtained by optical coherence combination fluorescence imaging；

Fig. 7 is image obtained by ultrasonic imaging combination fluorescence imaging；

Fig. 8 is three modality fusion images；

Fig. 9 is tissue pathological slice image.

Specific embodiment

Below in conjunction with the attached drawing in the embodiment of the present application, technical solutions in the embodiments of the present application carries out clear, complete Site preparation description, it is clear that described embodiments are only a part of embodiments of the present application, instead of all the embodiments.It is based on Embodiment in the application, it is obtained by those of ordinary skill in the art without making creative efforts every other Embodiment shall fall in the protection scope of this application.

Embodiment one

Fig. 1 is the structural schematic diagram that conduit device is peeped in one kind provided by the embodiments of the present application.

As shown in Figure 1, peeping conduit device in provided in this embodiment applied to multi-mode imaging system, multi-modality imaging system It unites and carries out medical imaging for the sample tissue to pancreatic duct, correspondingly, the interior conduit device of peeping is for importeding by the person's of examining In pancreatic duct.The interior conduit device of peeping includes casing 110 and the interior snooping head 120 that the cannula tip is arranged in.

The optical fiber 111 and signal wire 112 for connecting imaging device are provided in casing, specifically, optical fiber is used for The optical imaging device in imaging device is connected, signal wire is then used to connect the supersonic imaging device in imaging device.

Interior snooping head includes optical focus module 121 and ultrasonic transducer 122, which connect with optical fiber, Optical signal launch for transmitting optical fiber is also used to the light feedback letter that collecting sample tissue is reflected to sample tissue Number and export to optical imaging device.Ultrasonic transducer is connect with signal wire, the ultrasound control letter for being transmitted according to signal wire Number emit ultrasonic wave to sample tissue, and the feedback ultrasonic wave that sample tissue is fed back is converted into ultrasonic feedback signal, so that The ultrasound feedback signal is back to supersonic imaging device.

Ultrasonic transducer can reduce the thickness of ultrasonic transducer using loud absorbent properties material as its back lining materials Degree efficiently uses the space in casing.On the one hand so that the size of casing is less than 1mm, on the other hand make the hard length of casing front end Degree shortens.

The optical focus module includes hemispheric light transmission ball 1211, and a part and optical fiber of the sphere of the light transmission ball connect It connects, is provided with gold-plated reflectance coating in the horizontal bottom 1212 of light transmission ball, the axial direction of the horizontal bottom and optical fiber angle at 45 °, so that The optical signal that optical fiber transmission comes is radiated on sample tissue by the gold-plated reflectance coating with the direction at 90 ° of angles.

And the direction of the launch of the ultrasonic transducer and the casing is axially vertical and opposite with the direction of the launch of optical signal From.

Conduit device is peeped in one kind it can be seen from the above technical proposal that present embodiments providing, including casing and interior is peeped Probe, described sleeve pipe is interior to accommodate useful optical fiber and signal wire in connection imaging device；The interior snooping head is arranged in the set The end of pipe, including optical focus module and ultrasonic transducer, the optical focus module are connect with the optical fiber, the ultrasound Energy converter is connect with the signal wire.Since optical focus module therein can carry out optics letter to the sample tissue of pancreatic duct Number acquisition, ultrasonic transducer then can carry out ultrasonic signal acquisition to the sample tissue, can be realized it is primary import realize it is a variety of The medical imaging of mode, so as to considerably reduce by the pain for the person of examining.

In addition, Marking ring is for marking as shown in Fig. 2, the interior conduit device of peeping in the present embodiment further includes Marking ring 113 The position of interior snooping head in space, to correct the spatial relation of imaging.

In addition, being provided with photoelectricity slip ring assembly 50 as shown in figure 3, peeping in the casing in conduit device in this, the photoelectricity is sliding Ring assemblies include rotary photoelectric coupling unit 51 and rotation motor 52.There is optical collimator comprising one in rotary photoelectric coupling unit The smooth ring and an electric slip ring constituted, in the case where both ends being allowed to have relative rotation, synchronous transfer optical signal and electric signal. And the rotation of rotary photoelectric coupling unit provides power by rotation motor.It realizes the rotation of imaging catheter, withdraw scanning, obtain pancreas gallbladder Mechanical movement needed for three-dimensional imaging in managing.

Casing and interior snooping are thrown under the driving of rotary photoelectric coupling unit, and uniform rotation is made, to realize to pancreatic duct The imaging of upper sample tissue.One end of rotary photoelectric coupling unit is connected respectively at optical imaging device, supersonic imaging device, separately One end is then connect with the optical focus module of the interior snooping head of casing, ultrasonic transducer.

Embodiment two

Fig. 4 is a kind of block diagram of the multi-mode imaging system of pancreatic duct of the embodiment of the present application.

As shown in figure 4, multi-mode imaging system provided in this embodiment is used for respective sample tissue on the pancreatic duct of people It is imaged, to obtain the medical image of the sample tissue.The multi-mode imaging system includes image processing apparatus 10, optics Imaging device 20, supersonic imaging device 30 and interior peep conduit device 100.

The image processing apparatus is connected respectively at optical imaging device, supersonic imaging device signal, inside peeps conduit device then It is connect respectively with optical imaging device, supersonic imaging device signal.Specifically, this it is interior peep conduit device for enter human body in At portion and the sample tissue of going directly, specifically includes casing 110 and the interior snooping head 120 of the end of the casing is set, this is interior to peep Probe includes optical focus module and ultrasonic transducer.

Image processing apparatus is for receiving user to its operation and generating corresponding control signal, and it is defeated to control signal Optical imaging device and supersonic imaging device connected to it are arrived out, to control optical imaging device output optical signal, and are controlled Supersonic imaging device exports corresponding super acoustic control signal.

The optical signal of optical imaging device output is passed through in above-mentioned by optical fiber peeps conduit device, and is output to and interior peeps conduit The interior snooping head of device, and pass through the interior optical focus module for spying upon head for the sample tissue of optical signal launch to pancreatic duct On, which is also used to the optical feedback signal that the sample tissue is reflected under optical signal irradiation.Optical focus mould Block is fed back to the optical imaging device after receiving the optical feedback signal, and optical imaging device is according to the optical feedback signal It generates the first feedback signal and the first feedback signal is output to image processing apparatus.

Supersonic imaging device output super acoustic control signal be utilized conducting wire be sent in peep conduit device, specifically It is sent to the interior ultrasonic transducer for peeping interior snooping head in conduit device.Ultrasonic transducer can convert the electric signal received For ultrasonic wave, and receives to reflect ultrasonic wave and be converted into electric signal.Specific to this programme, which is used for basis should Super acoustic control signal emits super body wave to sample tissue, and is super by the feedback ultrasound transfer that the sample tissue received is reflected Acoustic feedback signal, and ultrasonic feedback signal is sent to the supersonic imaging device by respective wire.

Supersonic imaging device is handled it, after the ultrasonic feedback signal for receiving ultrasonic transducer feedback by it The second feedback signal is converted to, and sends above-mentioned image processing apparatus for second feedback signal.

Image processing apparatus is and super in the first feedback signal for receiving optical imaging device and being generated according to optical feedback signal After the second feedback signal that acoustic imaging apparatus is generated according to ultrasonic feedback signal, to first feedback signal and the second feedback signal It is handled, to obtain the medical image of sample tissue on the pancreatic duct, user is according to the medical image and corresponding medicine Knowledge can judge the state of pancreatic duct.

It can be seen from the above technical proposal that a kind of multi-mode imaging system of pancreatic duct is present embodiments provided, including Image processing apparatus, optical imaging device, supersonic imaging device and interior peep conduit device.Image processing apparatus respectively with optics at As device, supersonic imaging device signal connect, inside peep conduit device also respectively with optical imaging device, supersonic imaging device signal Connection, inside peeps conduit device according to the optical signal feedback optical feedback signal of optical imaging device, and according to supersonic imaging device Super acoustic control signal feeds back ultrasonic feedback signal, and final image processing unit is obtained according to optical feedback signal and ultrasonic feedback signal The medical image of sample tissue on pancreatic duct, so that user can be according to the image and corresponding medical knowledge to the shape of pancreatic duct State is judged, specifically can decide whether that canceration occurs.

In addition, optical imaging device includes different first of image-forming principle in the specific embodiment of the application Optical imaging device 21 and the second optical imaging device 22, as shown in figure 5, the two is connect with image processing apparatus signal respectively. It further include the wavelength division multiplexer 23 being connect respectively with the first optical imaging device, the second optical imaging device signal, wavelength-division multiplex One end of device passes through the first optical fiber 231 respectively and connect with the first optical imaging device signal, by the second optical fiber 232 and the second light Learn the connection of imaging device signal, wavelength division multiplexer obtains the other end and then passes through third optical fiber and interior peep interior snooping head on conduit device The connection of optical focus module.

In this embodiment, the first optical imaging device can study for optical coherence imaging device or optoacoustic As device；Second optical imaging device then can be fluoroscopic imaging device or confocal microscopic image device.

In practical applications, we have obtained the three of atherosclerotic rabbit using offer technical solution in the present embodiment Modality images, respectively as shown in Fig. 6, Fig. 7, Fig. 8 and Fig. 9.Wherein Fig. 6 is image obtained by optical coherence combination fluorescence imaging, Fig. 7 For image obtained by ultrasonic imaging combination fluorescence imaging, Fig. 8 is three modality fusion images, and Fig. 9 is tissue pathological slice image.

In supersonic imaging device, the present invention is to novel piezoelectric material, such as MEMS monocrystalline/epoxy resin 1-3PIN-PMN-PT Relaxor ferroelectric monocrystal etc. and its performance are deeply developed, and the parameters such as its high-temperature dielectric peak, coercive electric field, residual polarization are analyzed, It is retrofited by doping and improves its mechanical performance and temperature stability.This project will use centre frequency >=50MHz, size~ The novel high-frequency ultrasonic transducer of 0.6mm, to improve the longitudinal resolution of ultrasound image.In terms of high frequency hardware system, it will adopt It is excited with wide bandwidth (> 200MHz) sinusoidal impulse, and cooperates low noise variable gain amplifier, to further increase high frequency ultrasound Picture quality.

For using the trigger signal of scanning source laser device to come synchronizing ultrasound and fluorescence imaging as master flip-flop.In addition, Optical coherence imaging device and fluoroscopic imaging device are combined using wavelength division multiplexer.For fluoroscopic imaging systems, we are adopted The light of transmitting is collected, with doubly clad optical fiber (DCF) coupler to guarantee the compact of three modal systems and stablize.

Semiconductor laser is included into excitation light for the excitation light source and DCF coupler of fluorescence imaging and transmitting light passes Defeated collection.In transmission process, composite light beam passes through one-site model core from input port to output port, the minor diameter of single-mode core Guarantee generates high optical energy density to surface texture, to realize efficient excitation.The fluorescence fired back is exported through DCF Multimode fibre to major diameter can be improved the ability of collection transmitting light and obtain fluorescence information in PMT by corresponding filtering.It is super Acoustic imaging then passes through acoustic generator/receiver and generates and detect ultrasonic signal.

In this multi-modal endoscopic imaging system, optical coherence imaging device use high speed VECSEL light source, it can be achieved that It is imaged over long distances；

For the surface antigen CD206 of specific marker M2 type macrophage in pancreas gallbladder cancer, constructing function near-infrared dye Expect indocyanine green label M2 type macrophage as novel fluorescence probe, specific recognition CD206, using semiconductor adjustable laser 680-750nm wave band as excitation light source, by PMT collection >=800nm fluorescence, realize thin to CD206+-M2 type macrophage The fluorescent molecules imaging of born of the same parents.To the integrated then according to optical coherence imaging/fluoroscopic imaging device difference wave of bimodal light path part Long situation chooses wavelength division multiplexer and optical coherence Imaged samples arm light source and fluorescent excitation light source is integrated into same single mode broadband Optic fibre light path；Semiconductor laser and DCF coupler for fluorescence imaging excitation light source are included into excitation light and transmitting light passes Defeated collection；This all -fiber light path design ensure that bimodal light path system is compact and stablizes.

In addition, also having done following design in system: in transmission process, composite light beam passes through one-site model core from input terminal Mouth arrives output port, and the minor diameter of single-mode core generates high energy density to surface texture, to realize efficient excitation.Hair Penetrating the major diameter that light is output to multimode fibre through DCF can be improved the ability for collecting transmitting light, carries out corresponding filtering and obtains in PMT Fluorescence information.

All the embodiments in this specification are described in a progressive manner, the highlights of each of the examples are with The difference of other embodiments, the same or similar parts between the embodiments can be referred to each other.

Although preferred embodiments of the embodiments of the present application have been described, once a person skilled in the art knows bases This creative concept, then additional changes and modifications can be made to these embodiments.So the following claims are intended to be interpreted as Including preferred embodiment and all change and modification within the scope of the embodiments of the present application.

Finally, it is to be noted that, herein, relational terms such as first and second and the like be used merely to by One entity or operation are distinguished with another entity or operation, without necessarily requiring or implying these entities or operation Between there are any actual relationship or orders.Moreover, the terms "include", "comprise" or its any other variant meaning Covering non-exclusive inclusion, so that process, method, article or terminal device including a series of elements not only wrap Those elements are included, but also including other elements that are not explicitly listed, or further includes for this process, method, article Or the element that terminal device is intrinsic.In the absence of more restrictions, being wanted by what sentence "including a ..." limited Element, it is not excluded that there is also other identical elements in process, method, article or the terminal device for including the element.

Technical solution provided herein is described in detail above, specific case used herein is to this Shen Principle and embodiment please is expounded, the present processes that the above embodiments are only used to help understand and its Core concept；At the same time, for those skilled in the art, according to the thought of the application, in specific embodiment and application There will be changes in range, in conclusion the contents of this specification should not be construed as limiting the present application.

Claims (6)

1. peeping conduit device in one kind, which is characterized in that including casing and interior snooping head, in which:

Useful optical fiber and signal wire in connection imaging device is accommodated in described sleeve pipe；

The end of described sleeve pipe is arranged in the interior snooping head, including optical focus module and ultrasonic transducer, the optics gather Burnt module is connect with the optical fiber, and the ultrasonic transducer is connect with the signal wire.

2. peeping conduit device in as described in claim 1, which is characterized in that the optical focus module includes hemispheric Photosphere, in which:

A part of the light transmission ball is connect with the optical fiber；

Gold-plated reflectance coating is provided in the horizontal bottom of the light transmission ball.

3. peeping conduit device in as described in claim 1, which is characterized in that the direction of the launch of the optical focus module and institute The direction of the launch for stating ultrasonic transducer mutually deviates from.

4. peeping conduit device in as claimed in any one of claims 1 to 3, which is characterized in that it further include setting flag ring, it is described Marking ring is arranged in the end.

5. peeping conduit device in as claimed in any one of claims 1 to 3, which is characterized in that further include photoelectricity slip ring assembly, institute One end of photoelectricity slip ring assembly is stated for connecting with the imaging device signal, the other end is used for poly- by optical fiber and the optics Burnt module by signal connection is connect by the signal wire with the ultrasonic transducer signal.

6. peeping conduit device in as claimed in claim 5, which is characterized in that the photoelectricity slip ring assembly includes rotary photoelectric Coupling unit and rotary drive motor for driving rotary photoelectric coupling unit rotation.