CN209661864U - A kind of mouse intestinal auto-flushing collection device - Google Patents
A kind of mouse intestinal auto-flushing collection device Download PDFInfo
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- CN209661864U CN209661864U CN201821522317.1U CN201821522317U CN209661864U CN 209661864 U CN209661864 U CN 209661864U CN 201821522317 U CN201821522317 U CN 201821522317U CN 209661864 U CN209661864 U CN 209661864U
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- pipette
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Abstract
Mouse intestinal auto-flushing collection device provided by the utility model, including pouring pipe, pipette, peristaltic pump, infusion bottle and receiving flask；Pouring pipe connects the liquid outlet of the first peristaltic tube of peristaltic pump, and the inlet of the first peristaltic tube connects infusion bottle；Pipette connects the inlet of the second peristaltic tube of peristaltic pump, and the liquid outlet of the second peristaltic tube connects receiving flask；Imbibition pipe diameter is greater than liquid filling pipe diameter, and pouring pipe one end is located in pipette and the liquid feeding mouth of pouring pipe passes through the liquid sucting port of pipette；Liquid feeding mouth and liquid sucting port are hemisphere shell sape；Infusion bottle is placed in constant temperature water bath；Graduation mark and fixing clamp are also set up in pipette；A kind of mouse intestinal auto-flushing collection device of the utility model can carry out bowel lavage to mouse simultaneously and collect excrement；Facilitate control flow and accurately controls conveying capacity；It is controllable input liquid temperature and pipette insertion depth and facilitate fixation；It prevents mouse to be wounded by stabbing and reduces mouse sense of discomfort；Improve experiment comparability and accuracy.
Description
Technical field
The utility model belongs to mouse medical experiment equipment technical field, and in particular to a kind of mouse intestinal auto-flushing receipts
Acquisition means.
Background technique
In mammalian laboratory animals, since mouse is small in size, feeding management is convenient, and easily controllable, Reproduction is fast, grinds
Study carefully most deep, has specific quality control standard, possessed a large amount of inbred strais, mutantion line and closed colony, therefore in various experiments
In research, dosage is maximum, and purposes is most.In existing many zooperies need that mouse is used to be filled as animal model
Intestines experiment, some experiments also need to collect stool in mice and carry out the detection such as microorganism.It is often used in existing mouse bowel lavage experiment
Syringe is directly protruding into mouse intestinal and carries out liquid injection, since injection-tube head is sharp, injection depth, temperature, injection speed
Not easy to control with injection volume, injection pressure is also inconvenient to adjust, and leads to experimental repeatability poor or easily cause enteron aisle discomfort to lead
It causes it to generate stress reaction, influences to test accuracy.Existing enema syringe can not also collect excrement in mouse intestinal.Stool in mice
It is easy to receive external environmental after discharge, causes microbial flora in excrement to change, influence laboratory test results accuracy.
Chinese patent CN207152675U discloses a kind of porous rat enema syringe, including storing medicine bottle, enema tube, feature
Be: the enema tube includes hickey, and the hickey is set to the left end of enema tube, and hickey and enema tube phase
It connects；The storing medicine bottle includes nipple, and the nipple is set to the right end of storing medicine bottle, and the nipple and storage
Medicine bottle is connected；The nipple complements one another with hickey, and the storing medicine bottle is threaded into interface by nipple
It is connected with enema tube.The right end of enema tube is set as arc surface；Enema fluid can pass through multiple upper liquid filling pores, multiple lower liquid filling pores
Pour into intestine in rats.Pass through the setting of scale marker, so that it may which clear enema tube enters the depth of intestine in rats, according to required straight
Up to site of action.Meanwhile being arranged by the small volume of the storing medicine bottle of 2ml, accurate rat bowel lavage dose.The knot of the utility model
Structure is simply and the cost of production is low, and observation can be facilitated to adjust injection depth, but cannot automatically inject simultaneously control accurate beam amount
And injection volume；It also can not automatic collection enteron stool.
Chinese patent CN207024144U discloses a kind of multi-functional rat enema syringe, it is characterized in that: the enema tube
Right part passes through governor, and the sacculus is set to the left part of enema tube；The drenching bottle includes connecting tube, nipple joint, described
Connecting tube is set to the left end of drenching bottle, and the nipple joint is set to the left end of connecting tube, and the nipple joint, connection
Pipe, drenching bottle are interconnected；The enema tube includes attachment base, and the attachment base is set to the right end of enema tube；The connection
Connection Luo Dong is additionally provided in seat, and the connection Luo Dong is connected with enema tube；The left end of the enema tube is set as smooth
Arc surface；The nipple joint complements one another with Luo Dong is connect, the drenching bottle by nipple joint be screwed into connection Luo Dong with
Enema tube is connected.The structure of the utility model is simple, has hand governor, but can not accurately be arranged and control stream
Amount, and cannot be used for automatic collection enteron stool.
Summary of the invention
In order to overcome the deficiencies of the prior art, one of the technical issues of the utility model aims to solve at least in the prior art,
A kind of mouse intestinal auto-flushing collection device is provided, pouring pipe, pipette are connected by peristaltic pump, automatic filling can be achieved at the same time
Intestines and collection stool in mice.
The utility model is achieved through the following technical solutions: a kind of mouse intestinal auto-flushing collection device, including is filled
Liquid pipe, pipette, peristaltic pump, infusion bottle and receiving flask；The liquid outlet of first peristaltic tube of the pouring pipe connection peristaltic pump, the
The inlet of one peristaltic tube connects infusion bottle；The inlet of second peristaltic tube of the pipette connection peristaltic pump, second wriggles
The liquid outlet of pipe connects receiving flask；The imbibition pipe diameter is greater than liquid filling pipe diameter, and pouring pipe one end is located in pipette and fills
The liquid feeding mouth of liquid pipe passes through the liquid sucting port of pipette.First peristaltic tube and the second peristaltic tube can be by identical or different compacted
Dynamic pump driving.
A kind of mouse intestinal auto-flushing collection device of the utility model uses peristaltic pump cooperation pouring pipe and pipette
Liquid filling and imbibition can be achieved at the same time, and setting can be facilitated and adjust the flow of liquid filling and imbibition；Pouring pipe and pipette are set with one heart
It sets and more easily enters mouse anus, reduce the sense of discomfort and stress reaction of mouse, avoid influencing experimental result；Liquid is from infusion bottle
After inputting mouse intestinal by pouring pipe, mixed with excrement, be then discharged to receiving flask from pipette, whole process close into
Row, not by external environmental, does not also contact with the pump head of peristaltic pump, reduces probability of the excrement by outside contamination.Before use
It then can start again bowel lavage experiment first by peristaltic tube, pouring pipe, pipette, receiving flask and infusion bottle by sterilizing.
Preferably, the imbibition pipe diameter is 1.5~3 times of liquid filling pipe diameter；And pouring pipe stretches out the imbibition of pipette
Length outside mouthful is 2~3cm.
Preferably, the liquid feeding mouth of the pouring pipe is to be provided with multiple circular liquid filling pores on hemisphere shell mould and spherical shell.
Preferably, the liquid sucting port of the pipette is the imbibition slot that multiple spoke shapes are arranged on hemisphere shell sape and spherical shell.
Preferably, the sum of area of multiple liquid filling pores is equal to the sum of the area of multiple imbibition slots.
The above preferred pipette and liquid filling pipe size, liquid feeding mouth, liquid sucting port and hole shape and area can not only prevent
Mouse intestinal is wounded by stabbing, and is directly sucked in pipette after can preventing liquid from entering enteron aisle；Also it is more suitable for synchronizing liquid filling and suction
Liquid, conveniently adjusted identical liquid filling and rate of liquid aspiration.
Preferably, the infusion bottle is placed in constant temperature water bath.Infusion bottle is subjected to homogeneous heating and good constant-temperature effect, it can
Cold water stimulating mouse intestinal is prevented, its drug effect can also be improved to the specific temperature of some drugs.
Preferably, the peristaltic pump is the micro distribution formula peristaltic pump of multichannel and has liquid crystal display.The wriggling
Pump can connect multiple peristaltic tubes to the synchronous progress imbibition of multiple mouse and liquid filling simultaneously, improve Experimental comparison's property, and can be more smart
Quasi- control pump output shows more convenient observation by liquid crystal display.
Preferably, graduation mark is provided in the pipette.It is inserted by the conveniently adjusted pipette of observation graduation mark small
The depth of mouse anus.
Preferably, it is additionally provided with positioning ring in the pipette, is fixedly connected with fixing clamp on positioning ring.It will using fixing clamp
Pipette is fixed on mouse fixing device, can prevent its movement.
Opposite and the prior art, the utility model have the advantage that a kind of mouse intestinal of the utility model rushes automatically
Bowel lavage can be carried out to mouse simultaneously and collect excrement by washing collection device；Facilitate control flow and accurately controls conveying capacity；It is adjustable
The temperature of control input liquid and the depth of pipette insertion；Facilitate fixation；It prevents mouse to be wounded by stabbing and reduces mouse sense of discomfort；It mentions
Height experiment comparability and accuracy.
Detailed description of the invention
Fig. 1 is a kind of schematic diagram of mouse intestinal auto-flushing collection device of the utility model embodiment 1.
Fig. 2 is a kind of schematic diagram of mouse intestinal auto-flushing collection device of the utility model embodiment 2.
Fig. 3 is that the amplification of pouring pipe in a kind of mouse intestinal auto-flushing collection device of the utility model embodiment 1 is shown
It is intended to.
Fig. 4 is that the amplification of pipette in a kind of mouse intestinal auto-flushing collection device of the utility model embodiment 1 is shown
It is intended to.
In figure: 1, pouring pipe；2, pipette；3, peristaltic pump；4, infusion bottle；5, receiving flask；6, the first peristaltic tube；7, second
Peristaltic tube；8, liquid feeding mouth；9, liquid sucting port；10, constant temperature water bath；11, fixing clamp；12, graduation mark；13, liquid filling pore；14, imbibition
Slot.
Specific embodiment
In order to make the purpose of the utility model, technical solutions and advantages more clearly understood, with reference to embodiments, to this
Utility model is further elaborated.It should be appreciated that specific embodiment described herein is only used to explain that this is practical
It is novel, it is not used to limit the utility model.Based on the embodiments of the present invention, those of ordinary skill in the art are not having
Every other embodiment obtained under the premise of creative work is made, is fallen within the protection scope of the utility model.
It is in the description of the present invention, it should be noted that term " center ", "upper", "lower", "left", "right", " perpendicular
Directly ", the orientation or positional relationship of the instructions such as "horizontal", "inner", "outside" is to be based on the orientation or positional relationship shown in the drawings, and is only
For ease of description the utility model and simplify description, rather than the device or element of indication or suggestion meaning must have it is specific
Orientation, be constructed and operated in a specific orientation, therefore should not be understood as limiting the present invention.In addition, term " the
One ", " second ", " third " are used for descriptive purposes only and cannot be understood as indicating or suggesting relative importance.
Embodiment 1
As shown in Figure 1, a kind of mouse intestinal auto-flushing collection device, including it is pouring pipe 1, pipette 2, peristaltic pump 3, defeated
Liquid bottle 4 and receiving flask 5；The pouring pipe 1 connects the liquid outlet of the first peristaltic tube 6 of peristaltic pump 3, the feed liquor of the first peristaltic tube 6
Mouth connection infusion bottle 4；The pipette 2 connects the inlet of the second peristaltic tube 7 of peristaltic pump 3, the liquid outlet of the second peristaltic tube 7
Connect receiving flask 5；2 diameter of pipette is greater than 1 diameter of pouring pipe, and 1 one end of pouring pipe is located in pipette 2 and pouring pipe 1
Liquid feeding mouth 8 pass through pipette 2 liquid sucting port 9；Pouring pipe is passed through from the tube wall of pipette, wear mouthful at sealed with sealant.
First peristaltic tube 6 and the second peristaltic tube 7 are driven by two different micro peristaltic pumps 3.Peristaltic tube is to disappear
The high temperature resistant silicon sebific duct that poison is crossed.
2 diameter of pipette is twice of 1 diameter of pouring pipe；And pouring pipe 1 stretches out outside the liquid sucting port of pipette 2
Length is 2cm.The nozzle of one end standard-sized sheet of the pouring pipe is liquid feeding mouth；The nozzle of one end standard-sized sheet of the pipette is
Liquid sucting port.
A kind of mouse intestinal auto-flushing collection device of the present embodiment the utility model uses two different peristaltic pumps
It is separately connected pouring pipe and liquid filling and imbibition can be achieved at the same time in pipette, and can be respectively set and adjust the stream of liquid filling and imbibition
Amount；Pouring pipe and pipette are arranged concentrically and diameter changes from small to big, and can enter mouse anus simultaneously, reduce mouse sense of discomfort and
Stress reaction avoids influencing experimental result；Liquid can be used for multiple small simultaneously in infusion bottle for multiple bowel lavage cleaning experiment
Mouse, also sustainable multiple filling small stream mix, then from suction after liquid inputs mouse intestinal by pouring pipe from infusion bottle with excrement
Liquid pipe is discharged to receiving flask, and pipette is different with liquid filling length of tube, is directly sucked in pipette after can preventing liquid from entering enteron aisle；It is whole
A process closing carries out, and not by external environmental, does not also contact with the pump head of peristaltic pump, reduces excrement by outside contamination
Probability.
Embodiment 2
As shown in fig. 2 to 4, embodiment 1 is compared, first peristaltic tube 6 and the second peristaltic tube 7 of the present embodiment are by same micro-
Peristaltic pump 3 is measured to drive；The peristaltic pump is the micro distribution formula peristaltic pump of multichannel and has liquid crystal display；
The liquid feeding mouth 8 of the pouring pipe 1 is to be provided with multiple circular liquid filling pores 13 on hemisphere shell mould and spherical shell.
The liquid sucting port 9 of the pipette 2 is the imbibition slot 14 that multiple spoke shapes are arranged on hemisphere shell sape and spherical shell.
The sum of area of multiple liquid filling pores is equal to the sum of the area of multiple imbibition slots.
The infusion bottle 4 is placed in constant temperature water bath 10.
Graduation mark 12 is provided on 2 surface of pipette.
Fixed bonding has positioning ring on 2 surface of pipette, and fixing clamp 11 is fixedly connected on positioning ring.
It is other same as Example 1.
Compared with Example 1, the present embodiment connects pouring pipe and imbibition using the micro distribution formula peristaltic pump of multichannel simultaneously
Pipe；More convenient accurate flow control and pump output simultaneously can show the parameters such as flow, liquid feeding mouth and the liquid sucting port more light of hemisphere shell mould
Sliding, enteron aisle and anus are stabbed in reduction；The design of liquid filling slot and imbibing hole is more suitable for synchronizing liquid filling and imbibition, can facilitate
Adjust identical liquid filling and rate of liquid aspiration；The temperature of controllable input liquid and the depth of pipette insertion；Facilitate fixation；Into one
Step, which reduces, stimulates mouse, reduces mouse sense of discomfort；Improve experiment comparability and accuracy.
While there has been shown and described that the embodiments of the present invention, for the ordinary skill in the art,
It is understood that these embodiments can be carried out with a variety of variations in the case where not departing from the principles of the present invention and spirit, repaired
Change, replacement and variant, the scope of the utility model is defined by the appended claims and the equivalents thereof.
Claims (9)
1. a kind of mouse intestinal auto-flushing collection device, which is characterized in that including pouring pipe, pipette, peristaltic pump, infusion bottle
And receiving flask；The liquid outlet of first peristaltic tube of the pouring pipe connection peristaltic pump, the inlet of the first peristaltic tube connect infusion
Bottle；The inlet of second peristaltic tube of the pipette connection peristaltic pump, the liquid outlet of the second peristaltic tube connect receiving flask；It is described
Imbibition pipe diameter is greater than liquid filling pipe diameter, and pouring pipe one end is located in pipette and the liquid feeding mouth of pouring pipe passes through the suction of pipette
Liquid mouth.
2. a kind of mouse intestinal auto-flushing collection device according to claim 1, which is characterized in that the pipette is straight
Diameter is 1.5~3 times of liquid filling pipe diameter；And the length that pouring pipe stretches out outside the liquid sucting port of pipette is 2~3cm.
3. a kind of mouse intestinal auto-flushing collection device according to claim 2, which is characterized in that the pouring pipe
Liquid feeding mouth is to be provided with multiple circular liquid filling pores on hemisphere shell mould and spherical shell.
4. a kind of mouse intestinal auto-flushing collection device according to claim 3, which is characterized in that the pipette
Liquid sucting port is the imbibition slot that multiple spoke shapes are arranged on hemisphere shell sape and spherical shell.
5. a kind of mouse intestinal auto-flushing collection device according to claim 4, which is characterized in that multiple liquid fillings
The sum of the area in hole is equal to the sum of the area of multiple imbibition slots.
6. a kind of mouse intestinal auto-flushing collection device according to claim 1, which is characterized in that the infusion bottle is set
In constant temperature water bath.
7. according to claim 1 to a kind of 6 described in any item mouse intestinal auto-flushing collection devices, which is characterized in that institute
Peristaltic pump is stated to be the micro distribution formula peristaltic pump of multichannel and there is liquid crystal display.
8. according to claim 1 to a kind of 6 described in any item mouse intestinal auto-flushing collection devices, which is characterized in that institute
It states and is provided with graduation mark in pipette.
9. a kind of mouse intestinal auto-flushing collection device according to claim 1, which is characterized in that in the pipette
It is additionally provided with positioning ring, is fixedly connected with fixing clamp on positioning ring.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821522317.1U CN209661864U (en) | 2018-09-18 | 2018-09-18 | A kind of mouse intestinal auto-flushing collection device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821522317.1U CN209661864U (en) | 2018-09-18 | 2018-09-18 | A kind of mouse intestinal auto-flushing collection device |
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| Publication Number | Publication Date |
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| CN209661864U true CN209661864U (en) | 2019-11-22 |
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| CN201821522317.1U Active CN209661864U (en) | 2018-09-18 | 2018-09-18 | A kind of mouse intestinal auto-flushing collection device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112710823A (en) * | 2020-12-17 | 2021-04-27 | 中国科学院深圳先进技术研究院 | In-vitro detection system for intestinal transitional compound motion and application thereof |
-
2018
- 2018-09-18 CN CN201821522317.1U patent/CN209661864U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112710823A (en) * | 2020-12-17 | 2021-04-27 | 中国科学院深圳先进技术研究院 | In-vitro detection system for intestinal transitional compound motion and application thereof |
| CN112710823B (en) * | 2020-12-17 | 2024-03-29 | 中国科学院深圳先进技术研究院 | In-vitro detection system for intestinal motility compound motion and application thereof |
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