CN209628416U - Prepare the device of animal models of depression - Google Patents
Prepare the device of animal models of depression Download PDFInfo
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- CN209628416U CN209628416U CN201920311650.6U CN201920311650U CN209628416U CN 209628416 U CN209628416 U CN 209628416U CN 201920311650 U CN201920311650 U CN 201920311650U CN 209628416 U CN209628416 U CN 209628416U
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Abstract
The utility model discloses a kind of device for preparing animal models of depression, which includes cabinet, pallet, thermostat units, light illuminating unit, noise unit and control system；The lower part of cabinet is equipped with leakage excrement net, and pallet is located at the lower section of leakage excrement net, and leakage excrement net drains to the excreta of animal in pallet for carrying animal；Thermostat units are for adjusting box interior temperature；Illumination apparatus is used to provide duration illumination into cabinet；Noise unit is for imposing noise into cabinet；Control system is used to control the work of the thermostat units, light illuminating unit and noise unit.The device integrates a variety of mild Coping styles, at random, leniently stimulate to animal, more the formation state close to the simulation most of depression of the mankind.
Description
Technical field
The utility model relates to a kind of devices for preparing animal models of depression.
Background technique
Depression is a kind of complicated affective disorder disease including a variety of mental symptoms and somatization.It is clinical
Performance mainly has the excessively low mental symptom of low mental state, hebetude, retardation of thinking, self-assessment.It is pre- according to the World Health Organization
It surveys, the year two thousand twenty depression, which will become, is only second to the cardiopathic second largest harmfulness disease.Therefore for depression prevention and
The research for treating expansion is imperative, and the depression model for establishing reasonable operability is the basis of research.
There are mainly three types of modes for the foundation of animal models of depression at present: first is that using drug, such as apomorphine, reserpine
Or the drugs such as 5-HT carry out drug modeling, second is that cerebral injury modeling is destroyed, third is that stress modeling.Stress modeling method include behavior
Desperate (BD), chronic restricted stress (CRS), Learned helplessness (LH), novel environmental induction appetite stimulator (NIH) and it is chronic not
It is predictable mildly stress (CUMS) etc..Wherein, CUMS depression model carries out animal using the lower a variety of stimulus of intensity
Unpredictable stimulation, the method are widely used in the research of depression mechanism and antidepressant mechanism of action.But it should
The stimulation source category that method needs is more, and to the more demanding of laboratory equipment, the modeling time is long, and the work for increasing researcher is strong
Degree.
CN207897731U discloses a kind of animal depression inducing instrument, including single-chip computer control system, single-chip microcontroller control
System respectively with temperature control modules, acousto-optic stimulating module, thermal stimulus module, vibration tilt module and voltage stimulating module
It connects with signal；Thermal stimulus module and temperature control modules are all set in boxes and baskets, and temperature control modules are for detecting boxes and baskets
Interior temperature.This depression inducing instrument can automatic imitation generates electro photoluminescence, acousto-optic stimulates, hot environment and concussion tilt stimulation etc.
Laboratory facilities used in animal depression model modeling process, and by various stimulus together as one.It is applicant's understanding that the reality
With it is novel use it is a variety of stress method, wherein electro photoluminescence, acousto-optic stimulation and concussion inclination stimulation etc. directly contact animal body
Body stress method may all cause contact actual bodily harm to mouse, this injury may make mouse body be in tired shape
State, thus not entirely due to desperate and motionless shape occur in behaviouristics test evaluation (such as qutstanding tail test and Open field test)
State, to cause depression test evaluation result unreliable.In addition, modern's majority patients with depression is often not due to body
On injured by direct physics sexual stimulus and lead to mental depression, therefore the model can not the simulation mankind very well depression
Disease.
Therefore need a kind of device, the device can be realized chronic Unpredictability mildly stress, and more close to simulation
The formation state of the most of depression of the mankind.
Utility model content
In view of this, the purpose of this utility model is to provide a kind of preparation suppressions for integrating a variety of mild Coping styles
The device of strongly fragrant disease animal model can carry out animal at random, leniently to stimulate, closer to the simulation most of depression of the mankind
Formation state.Further, the modeling time of the animal models of depression of utility model device is shorter.
Specifically, the utility model is achieved by the following technical solution.
The utility model provides a kind of device for preparing animal models of depression, and described device includes cabinet, pallet, temperature adjustment
Unit, light illuminating unit, noise unit and control system；The lower part of the cabinet is equipped with leakage excrement net, and the pallet is located at the leakage
The lower section of excrement net, the leakage excrement net drain to the excreta of animal in the pallet for carrying animal；The thermostat units
For adjusting the box interior temperature；The illumination apparatus is used to provide duration illumination into cabinet；The noise unit
For imposing noise into cabinet；The control system is used to control the work of the thermostat units, light illuminating unit and noise unit
Make.
Device according to the present utility model controls thermostat units, light illuminating unit and noise unit work by control system
Make, the stimulation of no body contact injury is carried out to animal, builds similar with the environmental factor that most mankind suffer from depression
Atmosphere.Further, control system by random change stress type, around the clock to the intracorporal animal of case carry out
Mild stimulation, substantially reduces the settling time of model.
Device according to the present utility model, it is preferable that the thermostat units include cooling and warming fan, gas pipeline and temperature
Degree meter, the first port of the gas pipeline are connect with the cooling and warming fan, the second port grafting of the gas pipeline
In the cabinet roof and be connected to the inside of the cabinet, the thermometer is placed in the box house, for measuring
State the temperature of box house.In the utility model, the connection side of the roof of the second port of the gas pipeline and the cabinet
Formula is welding or is connected by connector, connects preferably by connector.The connector can be selected from flange or spiral shell
Line, preferably screw thread, a preferred embodiment according to the present utility model, the box top wall offers opening, described to open
The second port of mouth and the gas pipeline is connected through a screw thread.Device according to the present utility model, it is preferable that the refrigerated medium
The adjustable temperature of Hot-air fan is 0~70 DEG C, preferably 4~60 DEG C.The cooling and warming fan of the utility model is installed on outside cabinet
Portion, and connect by gas pipeline with the cabinet, it is transmitted to cold wind or hot wind steadily in cabinet, is buffered, prevented
The cold wind or hot wind of big wind-force closely act on animal bodies and damage.Embodiment according to the present utility model,
The cooling and warming fan is connect with the control system, and control system can according to need STOCHASTIC CONTROL temperature and start and stop,
It allows animal to experience at random hot and cold, causes the burnt dry and feeling of despair of animal.
Device according to the present utility model, it is preferable that the noise unit includes buzzer and decibel instrument, and the two is respectively provided with
In in the cabinet, buzzer is used to measure the relative loudness of the buzzer for imposing noise, decibel instrument into cabinet.Institute
The maximum relative loudness for stating buzzer is 120 decibels.Preferred embodiment according to the present utility model, the buzzer and decibel
The small volume of instrument does not occupy housing interior volume excessively, and the buzzer and decibel instrument may be provided at cabinet vertex, can be with
It prevents from being touched by animal.In the utility model, the buzzer is electrically connected with the control system, can control opening for buzzer
Stop, its relative loudness is optionally adjusted, noise stimulation is imposed to animal, is in impatience caused by noisy environment to simulate the mankind
Etc. moods.
In the utility model, light illuminating unit is headlamp, can provide duration illumination.Implementation according to the present utility model
Mode, the headlamp may be provided at cabinet vertex, to prevent from being touched by animal.Preferred implementation side according to the present utility model
Formula, the headlamp are electrically connected with the control system, can control the start and stop of headlamp, not timing in dim cabinet
Portion carries out normal, continuous light.Such as the circadian rhythm of animal can be overturned, it is allowed to stay up late closer to the mankind, evening rises etc. round the clock
The moods such as anxiety caused by arrhythmia behavior.
In the utility model, the control system is electrically connected with the thermostat units, noise unit and light illuminating unit, is used for
Control the work of said units.The control system can consider operation order and the time of setting each unit, can also set
Work at random for each unit, enhance the Unpredictability of stimulation, keep experimental animal unpredictable to stimulation mode and when
Between, to be more prone to produce impatience.
In the utility model, the shape of the cabinet is unlimited, preferably cuboid, such as square.It is practical new according to this
The device of type, it is preferable that the cabinet uses translucent black material (such as plastics or glass), for building box house
Dim environment, to be conducive to the intracorporal light application time of control cabinet.The lower part of the cabinet is equipped with leakage excrement net.The leakage excrement net
Material can be selected from least one of plastics, metal or fiber, and preferably plastics or metal, more preferably metal.According to
The device of the utility model, it is preferable that the area of the online single grid of the leakage excrement is less than or equal to 0.5 × 0.5cm, preferably small
In being equal to 0.4 × 0.5cm, more preferably less than or equal to 0.4 × 0.4cm.Setting can not only make animal excrements pass through net in this way
Lattice drain on pallet, additionally it is possible to it is within a grid and injured to guarantee that animal will not block when leaking excrement and walking on the net.
In the utility model, the pallet is located at the lower section of the leakage excrement net.The bottom of the pallet and the leakage excrement net
Distance be 0.5~3cm, preferably 0.8~2.5cm, more preferably 1.0~2.0cm.An implementation according to the present utility model
Two opposite side walls of mode, the lower part of the cabinet are equipped with horizontal strip-shaped clamp groove, for the insertion for the pallet
And extraction.Specifically, the lower part of a side wall of the cabinet offers strip gab, and adjacent with strip gab longitudinal direction both ends
Two opposite side walls on be respectively arranged with card slot, the card slot extends along strip gab to box house, and two clamp bar slots are high
It spends equal and is arranged in parallel, the pallet is plugged in the inside of cabinet from strip gab and is set up on the card slot.According to this
The another embodiment of utility model, the four corners of the pallet are provided with the first support column, each first support column
Top surface setting is fluted, the case while bottom of box is provided with the second support column, second support column and matching grooves
The bottom margin of body is engaged with the tip edge of pallet just.For holding wet padding, the padding can be the pallet
It is conventional use of those, such as Aspen wood shavings, corncob, paper scrap or pine etc., preferably pine or corncob.Wet padding is used for
Build box house wet environment.
Device according to the present utility model, it is preferable that the cabinet includes the first side wall and adjacent with the first side wall
Second sidewall, the first side wall is provided with openable and closable first chamber door, and the area of first chamber door accounts for first side
The 1/2~4/5 of wall area, preferably 2/3~3/4.First chamber door can be used for being put into or taking out experimental animal, box house
Cleaning etc..Preferably, first chamber door is identical as the material of cabinet, is black translucent material, such as black is translucent
Plastics or glass etc..It is provided with the second chamber door in the second sidewall of the cabinet, the area of second chamber door is described the
The 1/4~1/2 of two sidewall areas, preferably 1/3~1/2.Second chamber door observes animal for experimenter, launches feed
It is operated with drinking water etc..Second chamber door is transparent material (such as plastics or glass), to facilitate observation.It is leaned in the cabinet
Crib and sink are equipped at nearly second chamber door, such as the crib and sink can be set in leakage excrement net close to the second chamber door
Place, to facilitate operation.
Animal models of depression can be prepared using above-mentioned apparatus, specifically, animal can be placed in the cabinet, it is right
The animal applies stimulation, the hot environment or low temperature environment stimulation, light that the stimulation applies selected from thermostat units incessantly
According to the moist padding stimulation that the noisy environment that the continuous light that unit applies stimulates, noise unit applies stimulates, pallet provides, break
Water is jejunitas；The type of the stimulation applied in the same time to animal is one or two, and the type of adjacent stimulation is different.It adjusts
The temperature for the hot environment stimulation that warm unit applies is 40~45 DEG C, and the temperature of the low temperature environment stimulation of application is 0~6 DEG C, light
Intensity of illumination according to the continuous light stimulation that unit applies is 300~400lux, the relative loudness for the noise that noise unit applies
For 300~400lux, moist padding makes the intracorporal relative humidity 60%-80% of case in pallet.It is stimulated needed for animal model
Duration is 8~15 days, carries out 2~6 stimulations to animal daily, and the duration stimulated every time is 2~12h.
For example, depressed disease mouse model can be prepared using the modeling scheme of table 1, the refrigerated medium hot wind in described device
The temperature for fanning the hot environment stimulation applied to animal is 43 DEG C, and the temperature of low temperature environment stimulation is 4 DEG C, the lasting light of headlamp
It is 350lux according to intensity, the relative loudness of buzzer is 80 decibels, and moist padding makes the intracorporal relative humidity 70% of case.
Table 1
| Number of days (d) | Daytime (7:00-19:00) | Night (19:00-7:00) |
| 1 | Noisy environment | Continuous light |
| 2 | Moist padding | Noisy environment |
| 3 | Hot environment | Low temperature environment |
| 4 | It cuts off the water supply | It is jejunitas to cut off the water supply |
| 5 | Noisy environment | Hot environment |
| 6 | Low temperature environment | Moist padding |
| 7 | It is jejunitas to cut off the water supply | It cuts off the water supply |
| 8 | Moist padding | Continuous light |
| 9 | Hot environment | Noisy environment |
| 10 | It is jejunitas | Low temperature environment |
The modeling scheme is verified through qutstanding tail test and open field test, the modeling success in 10 days of depressed disease mouse model.
Utility model device can be contacted to avoid animal due to body by random, leniently stimulate to animal
Noxious stimulus and cause direct contact injury or adaptation or fatigue state to environmental stimulation occur, make the depression of manufacture
Model is more acurrate, closer to the formation state of the most of depression of the simulation mankind.Further, the control system of the utility model
System can STOCHASTIC CONTROL each unit stimulated round the clock, the settling time of animal model is short.
Detailed description of the invention
Fig. 1 is the device for preparing animal models of depression in embodiment 1.
The reference numerals are as follows:
11- cabinet, the first chamber door of 12-, the second chamber door of 13-, 20- pallet, 30- leakage excrement net, 40- buzzer, 50- illumination
Lamp, 60- thermostat units, 61- cooling and warming fan, 62- gas pipeline.
Specific embodiment
The utility model is further described combined with specific embodiments below, but the protection scope of the utility model is simultaneously
It is without being limited thereto.Unless otherwise stated, each component or device of the utility model are all made of component or dress known in the art
It sets.
Embodiment 1
A kind of device preparing animal models of depression, as shown in Figure 1, including cabinet 11, pallet 20, leakage excrement net 30, bee
Ring device 40, headlamp 50, thermostat units 60 and control system.Cabinet 11 is 30cm × 20cm × 20cm cuboid, material
For translucent black glass.
The lower part of one side wall of the cabinet 11 offers strip gab, and two adjacent with strip gab longitudinal direction both ends
Fitting is provided with card slot (not shown) respectively on a side wall, and for card slot along strip gab to 11 internal stretch of cabinet, two clamp bar slots are high
It spends equal and is arranged in parallel.Pallet 20 is plugged in 11 inside of cabinet from strip gab and is set up on card slot.It contains 20 bottom of pallet
It is placed with wet padding, the padding is Aspen wood shavings.
It is equipped with leakage excrement net 30 in cabinet 11, is located at the top of pallet 20, leakage excrement net 30 is at a distance from 20 bottom of pallet
1.0cm.The sizing grid for leaking excrement net 30 is 0.4 × 0.4cm.
One vertex of cabinet 11 is equipped with buzzer 40 and decibel instrument (not shown), another vertex is equipped with photograph
Bright lamp 50.The maximum relative loudness of buzzer 40 is 120 decibels.The small volume of buzzer 40, decibel instrument and headlamp 50.
Thermostat units 60 include cooling and warming fan 61, gas pipeline 62 and thermometer (not shown), cooling and warming fan
61 adjustable temperature is 4~60 DEG C.Cooling and warming fan 61 open after to gas pipeline 62 first port transporting cold wind or
The second port of hot wind, gas pipeline 62 is connected to by flange with the roof of cabinet 11.Thermometer is placed in inside cabinet 11, is used for
Measure 11 internal temperature of cabinet.
Cabinet 11 includes the first side wall and the second sidewall adjacent with the first side wall, and the first side wall is provided with can
First chamber door 12 of folding, the area of first chamber door 12 account for the first side wall area 4/5.First chamber door 12 and cabinet 11
Material it is identical, be translucent black glass.The second chamber door 13, second case are provided in the second sidewall of the cabinet 11
The area of door 13 is the 1/2 of the second sidewall area.The second chamber door material is transparent glass.Excrement net 30 is leaked close to second
Crib and sink (being not shown) are equipped at chamber door 13.
Control system is electrically connected with buzzer 40, headlamp 50, cooling and warming fan 61.
The utility model is not limited to the above embodiment, without departing substantially from the substantive content of the utility model,
It may occur to persons skilled in the art that any deformation, improvement, replacement each fall within the scope of the utility model.
Claims (10)
1. a kind of device for preparing animal models of depression, which is characterized in that described device include cabinet, pallet, thermostat units,
Light illuminating unit, noise unit and control system；The lower part of the cabinet is equipped with leakage excrement net, and the pallet is located at the leakage excrement net
Lower section, the leakage excrement net drain to the excreta of animal in the pallet for carrying animal；The thermostat units are for adjusting
Save the box interior temperature；The light illuminating unit is used to provide duration illumination into cabinet；The noise unit be used for
Noise is imposed in cabinet；The control system is used to control the work of the thermostat units, light illuminating unit and noise unit.
2. the apparatus according to claim 1, which is characterized in that the thermostat units include cooling and warming fan, appendix
Road and thermometer, the first port of the gas pipeline are connect with the cooling and warming fan, the second end of the gas pipeline
Mouth is plugged in the roof of the cabinet and is connected to the inside of the cabinet, and the thermometer is placed in the box house, is used for
Measure the temperature of the box house.
3. the apparatus according to claim 1, which is characterized in that the noise unit includes buzzer and decibel instrument, described
Buzzer and decibel instrument are respectively positioned in the cabinet, and for imposing noise into cabinet, the decibel instrument is used for the buzzer
Measure the relative loudness of the buzzer.
4. the apparatus according to claim 1, which is characterized in that the light illuminating unit is headlamp, and the headlamp is located at
The top of the side wall of the cabinet or roof.
5. the apparatus according to claim 1, which is characterized in that the area of the online single grid of the leakage excrement is less than or equal to
0.5×0.5cm。
6. device according to claim 5, which is characterized in that the bottom of the pallet is at a distance from the leakage excrement net
0.5~3cm.
7. described in any item devices according to claim 1~6, which is characterized in that the cabinet include the first side wall and with institute
The adjacent second sidewall of the first side wall is stated, the first side wall is provided with openable and closable first chamber door, the face of first chamber door
Product accounts for the 1/2~4/5 of the first side wall area.
8. device according to claim 7, which is characterized in that the second chamber door is provided in the second sidewall of the cabinet,
The area of second chamber door is the 1/4~1/2 of the second sidewall area.
9. device according to claim 8, which is characterized in that be equipped with crib in the cabinet at second chamber door
And sink.
10. described in any item devices according to claim 1~6, which is characterized in that the cabinet is translucent black cabinet.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201920311650.6U CN209628416U (en) | 2019-03-12 | 2019-03-12 | Prepare the device of animal models of depression |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201920311650.6U CN209628416U (en) | 2019-03-12 | 2019-03-12 | Prepare the device of animal models of depression |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109907000A (en) * | 2019-03-12 | 2019-06-21 | 山西中医药大学 | Prepare the device and method of animal models of depression |
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- 2019-03-12 CN CN201920311650.6U patent/CN209628416U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109907000A (en) * | 2019-03-12 | 2019-06-21 | 山西中医药大学 | Prepare the device and method of animal models of depression |
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