CN209611391U - The injection of tail intervertebral disc of rat microtrauma puncture and extraction element - Google Patents

Abstract

The utility model is a kind of injection of tail intervertebral disc of rat microtrauma puncture and extraction element, lantern ring including being located on rat-tail, piercing needle cartridge, position syringe and microsyringe, it is characterized by: the ring set is the C-shaped lantern ring of hollow half ring cylinder shape, Open Side Down when use, its top two sides is respectively equipped with the first positioning grafting cylinder with a scale and the second positioning grafting cylinder with a scale, middle part is equipped with the screw shell of grafting piercing needle cartridge, the axial centre of the first positioning grafting cylinder with a scale and the second positioning grafting cylinder with a scale is respectively equipped with the first positioning pinholes and the second positioning pinholes, interconnected axial trajectory and circumferential track are additionally provided on C-shaped lantern ring, the screw shell is equipped with internal screw thread half-via, cylinder is punctured for screwing in screw thread with a scale, and it is equipped with puncture hole, bottom is fixedly connected with sleeve-sliders, sleeve-sliders exist Sliding in the axial trajectory and circumferential track, the screw thread with a scale puncture cylinder side and are fixedly connected with graduated scale.

Description

The injection of tail intervertebral disc of rat microtrauma puncture and extraction element

Technical field

The utility model relates to a kind of devices of Bioexperiment, especially disclose a kind of tail intervertebral disc of rat microtrauma puncture Injection and extraction element, belong to medical instruments field.

Background technique

Pain in the loins is that have intervertebral disc degeneration etc. the main reason for perplexing a kind of very universal disease of the mankind, cause pain in the loins.It builds The animal model of suitable intervertebral disc degeneration is found to study the treatment method of various blockings or reverse degeneration of intervertebral disc especially It is important.Animal Lab. often studies the treatment method of various blockings or reverse degeneration of intervertebral disc, currently, most-often used big Mouse is easily operated anatomical position as experimental animal, the position of tail intervertebral disc of rat, and can light shirtsleeve operation reality Regression is now induced, therefore becomes intervertebral disc degeneration/regeneration research ideal model.

The study found that the damage of intervertebral disc structure mostly first occurs in fibrous ring, radioactive tearing of fibrous ring is often most It is easy to cause intervertebral disc degeneration, because the pressure balance of disc tissue has been broken in this tearing damage.Nucleus pulposus is along damage Fibrous ring is prominent, oppresses surrounding nerve to cause a series of symptom of pain in waist and lower extremities of the mankind.Spinal surgery vertebra is carried out at present Between disc degradation when studying, the position of tail intervertebral disc of rat is easily operated anatomical position, and can easily operate realization and lure Regression is led, therefore becomes intervertebral disc degeneration/regeneration research ideal model.However, the model mostly uses manually in the prior art Mode or mechanical disturbance induce intervertebral disc degeneration, using, since paracentesis depth is different, puncture needle thickness is different when manual type, effect Rate is low, so execution is inconsistent.When inducing intervertebral disc degeneration using mechanical disturbance, complicated operation is also needed, it is accurate External fixation device and mechanical detection instrument, and need to expend long time wait regression formed.

107898523 A of Chinese patent CN disclose provide a kind of high degree of automation for muroid experimental animal vertebra The instruments such as the device, including front frame, after-frame, needle stand, motor, puncture needle that disk punctures.The center of the front frame and after-frame is equipped with For passing through the through-hole of muroid experimental animal tail bone, when puncture, the clamping unit by the head end of muroid experimental animal tail bone and Tail end clamps, and needle stand is moved at the interverbebral disc of muroid experimental animal tail bone, and propulsion unit drives puncture needle to move forward and penetrate vertebra Disk.The puncture outfit structure is excessively accurate complicated, and manufacturing cost is high, since it lacks the location structure to rat-tail, unavoidably Have mechanical directional error such as: the angle of needle insertion and depth of needle, it is difficult to adapt to different-diameter tail intervertebral disc of rat and Different skin toughness, therefore, the puncture outfit are not suitable for tail intervertebral disc of rat microtrauma puncture use.

104622598 B of Chinese patent CN discloses a kind of tail intervertebral disc of rat percutaneous puncture injection device, has behaviour Make sleeve and be located at the operation needle spliced eye component, the puncture needle is for piercing through tail intervertebral disc of rat.But the device knot Structure is too simple, is to be difficult to accurately avoid the blood vessel and pygostyle of rat-tail, and penetrate in fibrous ring first；Followed by cannot Depth of needling is controlled, the nucleus pulposus without destroying rat；Last its is also difficult to inject drug to interverbebral disc, and precisely to predetermined amount Drug.

Summary of the invention

The purpose of this utility model is to solve the defect of the prior art, designs a kind of tail intervertebral disc of rat microtrauma puncture injection And extraction element, it is that a kind of structure is simple, fixing-stable, registration, paracentesis depth are controllable, with function of injection and mentions simultaneously The tail intervertebral disc of rat microtrauma puncture of rat tail bone nucleus pulposus is taken to inject extraction element.

The utility model is realized in this way: a kind of injection of tail intervertebral disc of rat microtrauma puncture and extraction element, including ring It is placed on lantern ring, piercing needle cartridge, positioning syringe and the microsyringe of rat-tail, it is characterised in that: the ring set is hollow semi-ring The C-shaped lantern ring of column structure, the C-shaped lantern ring is that Open Side Down when in use, and ring set lives rat-tail, and top two sides are set respectively There are the first positioning grafting cylinder with a scale and the second positioning grafting cylinder with a scale for patching positioning syringe, middle part is worn equipped with grafting The screw shell of puncture needle cartridge, the axial centre difference of the first positioning grafting cylinder with a scale and the second positioning grafting cylinder with a scale It is connected to equipped with the first positioning pinholes and the second positioning pinholes, and respectively with the hollow cavity of C-shaped lantern ring, the C-shaped lantern ring Be additionally provided with and be interconnected and the orbit altitude axial trajectory and circumferential track that match on the wall of half ring cylinder, and with C-shaped lantern ring Hollow cavity connection, two tracks are integrally in T-shaped distribution, and the screw shell is up big and down small stepped ramp type cylinder, The big section cylinder of top is equipped with internal screw thread half-via, punctures cylinder for screwing in screw thread with a scale, the segment cylinder bottom of lower section is solid Surely sleeve-sliders are connected with, the thickness of the sleeve-sliders is matched with the orbit altitude of axial trajectory and circumferential track, in institute It slides axially in the axial trajectory stated along C-shaped lantern ring, along the circumferential direction sliding of C-shaped lantern ring, the screw shell in circumferential track Internal screw thread half-via except the central axial position of cylinder be equipped with the central axial position that cylinder is punctured with the screw thread with a scale The cooperation of puncture hole size through-hole, and be connected to the hollow cavity of C-shaped lantern ring, the screw thread with a scale puncture cylinder is big The small nut bolt moulding matched with the size of screw shell, top are nut, and lower section is bolt, the bolt be equipped with The socket external screw thread that the internal screw thread half-via of the screw shell matches, the side of the nut are fixedly connected with scale Ruler, after the screw thread with a scale punctures cylinder screw-in screw shell, the graduated scale is in outside screw shell.

The positioning grafting cylinder with a scale of described first is up big and down small stepped ramp type cylinder, the segment diameter of axle and axial trajectory Track width cooperation, bottom are fixedly connected with grafting cylinder sliding block, and the radial section of the axial trajectory is in " ten " word on C-shaped lantern ring Shape, the grafting cylinder sliding block sliding, thickness and axial trajectory " ten " word along the transverse chambers body of axial trajectory " ten " font The lateral cavity of shape cooperates, and size is matched with the segment diameter of axle of the first positioning grafting cylinder with a scale, is axially simultaneously equipped with For positioning the scale mark of reference.

The positioning grafting cylinder with a scale of described first is screwed with the use integral type of grafting cylinder sliding block 13 or use, bonds Fixed form is fixedly connected, and the scale mark is the scale hole of vertical equidistant arrangement, the scale hole and the first positioning Pin hole connection.

Described second it is with a scale positioning patch cylinder be cylindrical, be directly fixedly connected with C-shaped collar body, be equipped with The identical scale hole of positioning grafting cylinder with a scale of described first.

Segment cylinder bottom use below the screw shell is screwed or is adhesively fixed mode and is fixedly connected with Sleeve-sliders, the graduated scale are equipped with the scale convex block of vertical equidistant arrangement.

The beneficial effects of the utility model are:

1. all-transparent plastic material can see four blood vessels on rat tail clearly, puncture needle is avoided to prick on blood vessel.

2.C shape lantern ring, can cover and move back and forth in rat-tail, adapt to the different tail of rat thickness.

3. first two pin puncture skins reach on tail bone bone.The average puncture depth of two needles is taken, to determine skin to vertebra The distance of bone, secondly intermediate puncture needle can vertically move puncture.(spiral inserting needle with a scale can limit depth of needle) It is more more accurate than previous puncture and easy.

3. the device of the invention also has function of injection, when needing to rat injecting fluid, can be injected to its interverbebral disc Drug, the outlet of puncture hole can connect insertion microsyringe, be convenient for dosed administration.

4. the device of invention also has the function of to extract nucleus pulposus, when needing to extract nucleus pulposus to rat, can use micro Sample injector extracts appropriate tissue, avoids tradition and puts to death the drawbacks of rat takes nucleus pulposus.

Detailed description of the invention

Fig. 1 is the structural schematic diagram of the utility model.

In figure: 1, C-shaped lantern ring；2, screw shell；3, the first positioning grafting cylinder with a scale；4, the second positioning with a scale Grafting cylinder；5, the first positioning pinholes；6, the second positioning pinholes；7, screw thread with a scale punctures cylinder；8, puncture hole；9, it carves Spend convex block；10, it is socketed external screw thread；11, axial trajectory；12, circumferential track；13, grafting cylinder sliding block；14, sleeve-sliders； 15, scale hole.

Specific embodiment

With reference to the accompanying drawings 1, the utility model is that a kind of tail intervertebral disc of rat microtrauma puncture is injected and extraction element, for mouse Fibrous ring microtrauma puncture or injecting fluid and extraction nucleus pulposus in tail, C-shaped lantern ring 1, puncture needle including being located on rat-tail Cylinder, positioning syringe and microsyringe.The C-shaped lantern ring 1 is hollow semi-ring column structure, and Open Side Down when use, and ring set is lived Rat-tail, top two sides be respectively provided with patch positioning syringe the first positioning grafting cylinder 3 and second with a scale it is with a scale fixed Position grafting cylinder 4, middle part is equipped with the screw shell 2 of grafting piercing needle cartridge.

The axial trajectory that interconnected and orbit altitude matches is additionally provided on the wall of the ring cylinder of the C-shaped lantern ring 1 11 and circumferential track 12, and be connected to the hollow cavity of C-shaped lantern ring 1, two tracks are integrally in T-shaped distribution.

The positioning grafting cylinder 3 with a scale of described first is up big and down small stepped ramp type cylinder, the segment diameter of axle and axial trajectory 11 track width cooperation, bottom are fixedly connected with grafting cylinder sliding block 13, the axial trajectory 11 C-shaped lantern ring 1 radially Section be in " ten " font, the grafting cylinder sliding block 13 can axial trajectory 11 " ten " font transverse chambers body in sliding, The lateral cavity of thickness and axial trajectory 11 " ten " font cooperates, and the segment axis of size and the first positioning grafting cylinder 3 with a scale Diameter matches.It is described first it is with a scale positioning grafting cylinder 3 axial centre be equipped with the first positioning pinholes 5, and with C-shaped lantern ring 1 Hollow cavity connection is axially simultaneously equipped with the scale mark for positioning reference.Positioning syringe is for positioning in order to facilitate observation of When be inserted into rat-tail depth, the scale mark be vertical equidistant arrangement scale hole 15, the scale hole 15 and first Positioning pinholes 5 are connected to.The positioning grafting cylinder 3 with a scale of described first and grafting cylinder sliding block 13 can be integral type, and spiral shell can also be used Line is fixed or is adhesively fixed mode and is fixedly connected.

It is cylindrical that the positioning with a scale of described second, which patches cylinder 4, is directly fixedly connected with 1 ontology of C-shaped lantern ring, so No setting is required is used for the step segment axis body of connection sliding block, and other structures with a scale position that patch cylinder 3 identical with first.

The screw shell 2 is up big and down small stepped ramp type cylinder, and the big section cylinder of top is equipped with internal screw thread half-via, Cylinder 7 is punctured for screwing in screw thread with a scale, company is fixed using being screwed or being adhesively fixed mode in the segment cylinder bottom of lower section Sleeve-sliders 14 are connected to, the thickness of the sleeve-sliders 14 is matched with the orbit altitude of axial trajectory 11 and circumferential track 12, It can slide axially or in circumferential track 12 along C-shaped lantern ring 1 along the circumferential direction sliding of C-shaped lantern ring 1 in the axial trajectory 11. The central axial position of cylinder except the 2 internal screw thread half-via of screw shell, which is equipped with, punctures cylinder 7 with the screw thread with a scale The through-hole of 8 size of the puncture hole cooperation of central axial position, and be connected to the hollow cavity of C-shaped lantern ring 1.Described is with a scale Screw thread punctures the nut bolt moulding that 7 size of cylinder is matched with the size of screw shell 2, and top is nut, and lower section is bolt, institute The bolt stated is equipped with the socket external screw thread 10 matched with the internal screw thread half-via of the screw shell 2.The side of the nut While being fixedly connected with graduated scale, the graduated scale is equipped with the scale convex block 9 of vertical equidistant arrangement.The screw thread with a scale After puncturing the screw-in screw shell 2 of cylinder 7, the graduated scale is in outside screw shell 2.

Preferably to be used convenient for the observation of the depth of needle of positioning syringe and piercing needle cartridge and accurate positioning, the utility model Bright material is made, and each scale hole 15 on the first positioning grafting cylinder 3 with a scale and the second positioning grafting cylinder 4 with a scale The spacing for puncturing each scale convex block 9 on graduated scale set by cylinder 7 with the screw thread with a scale is respectively set to 1mm.

The utility model is described in further detail in the following with reference to the drawings and specific embodiments.

Embodiment 1:

The internal diameter of C-shaped lantern ring 1 determines that the rat-tail diameter generally to be punctured is 7.75mm, the C-shaped according to rat-tail diameter Lantern ring 1 is designed to entangle rat-tail, and can move freely in rat-tail, to adapt to different rat-tail diameters.The present embodiment The length of middle C-shaped lantern ring is 25mm, and the outer diameter of C-shaped lantern ring is 13.175mm, and the height of C-shaped lantern ring is 26.519mm,

Meanwhile when inside the needle point piercing rat-tail of piercing needle cartridge, punctured with cylinder 7 from screw thread with a scale, needle point can spiral The fibrous ring and nucleus pulposus being inserted into inside rat-tail, needle point can only prick fibrous ring, can also continue deeper into nucleus pulposus center.One As experiment select be 21G needle, needle body is equidistantly equipped with several scales, wherein 21G pilot pin be outer diameter 0.80mm common needle, 21G puncture needle is the middle empty needle of outer diameter 0.80mm, can connect microsyringe for drug injection or extract nucleus pulposus.This implementation 2 μ l manual trace samplers of Shanghai Gao Ge Trade Co., Ltd. production are selected in example.

20 rat lumber ertebral discs are completely taken out, determine the point of interface of fibrous ring and nucleus pulposus, the thickness of Anular stab (mm) fiber ring thickness and to be attached to the sum of ligament thickness of fibrous ring.Skin to fibrous ring and nucleus pulposus is measured through preliminary experiment to hand over Depth at boundary is 3mm, and the depth for reaching nucleus pulposus center is 5mm, and puncture needle inserting needle has arrived fibrous ring and nucleus pulposus when being deeply 3mm Junctional area, continue deeper into and have breakthrough sense, then inserting needle 2mm can reach the center of nucleus pulposus.

Before injecting extraction element using the tail intervertebral disc of rat microtrauma puncture of the utility model, first C-shaped lantern ring 1 is set in In rat-tail.With reference to the accompanying drawings 1, when the utility model is used, it is with a scale fixed that the pilot pin that two position syringes is inserted into first respectively It is deep to can see inserting needle by the scale hole 15 being arranged on two grafting cylinders for position grafting cylinder 3 and the second positioning grafting cylinder 4 with a scale Degree, the pilot pin in left side can be moved by grafting cylinder sliding block 13 along axial trajectory 11, keep position gap more acurrate.Right positioner needle Since the second positioning grafting cylinder 4 with a scale is fixedly connected with C-shaped lantern ring, so playing fixed function, while can make to calculate inserting needle Depth is more accurate.From skin penetrating until navigating on coccyx, bilateral is averaged pilot pin.

After completing positioning, puncture needle starts spiral inserting needle, and puncture needle can puncture cylinder 7 with screw thread with a scale and rotate into screw thread Sleeve 2, depth of needle can be specified by puncturing the scale convex block 9 on the graduated scale being arranged on the outside of cylinder 7 by screw thread with a scale, and can be led to Sleeve-sliders 14 are overregulated along axial trajectory 11 or the sliding of circumferential track 12 to convert puncture position, keep puncture position more accurate. Illustrate to puncture if the bilateral scale average value positioned before can exceed that when puncture and be needled into fibrous ring, otherwise illustrates to puncture Gap is not right, can move C-shaped lantern ring 1 along axial trajectory 11 or circumferential track 12 continue to detect at this time, enters fibre until puncturing Tie up ring.

Through measuring, tail intervertebral disc of rat with a thickness of 1mm, and nucleus pulposus is not touched in puncture needle front end, needs to inject to rat-tail When liquid, puncture needle connects microsyringe and continues inserting needle along depth just now, and drug injection is entered in rat-tail interverbebral disc, if you need to Nucleus pulposus is extracted directly to draw.

Above-mentioned specific embodiment is to be familiar with this for that can understand and apply the invention creation convenient for those of ordinary skill in the art The personnel of field technology obviously easily can make various adaptations to the present embodiment according to the actual situation, and handle exists The General Principle of this explanation is applied in other embodiments without having to go through creative labor.Therefore, the utility model is unlimited In above-described embodiment, those skilled in the art's announcement according to the present utility model is made not departing from the utility model scope Equivalent modifications or equivalent replacement should all be within the protection scope of the utility model.

Claims (5)

1. a kind of tail intervertebral disc of rat microtrauma puncture injection and extraction element, including being located on the lantern ring of rat-tail, piercing needle cartridge, determining Position syringe and microsyringe, it is characterised in that: the ring set is the C-shaped lantern ring of hollow semi-ring column structure, the C-shaped Ring set lives rat-tail that lantern ring is that Open Side Down when in use, top two sides, which are respectively provided with, to be patched the first band of positioning syringe and carves Degree positioning grafting cylinder and the second positioning grafting cylinder with a scale, middle part are equipped with the screw shell of grafting piercing needle cartridge, the first band The axial centre of scale positioning grafting cylinder and the second positioning grafting cylinder with a scale is respectively equipped with the first positioning pinholes and the second positioning Pin hole, and be connected to respectively with the hollow cavity of C-shaped lantern ring, it is additionally provided on the wall of half ring cylinder of the C-shaped lantern ring and mutually interconnects The axial trajectory and circumferential track that logical and orbit altitude matches, and be connected to the hollow cavity of C-shaped lantern ring, two tracks are integrally in T-shaped distribution, the screw shell are up big and down small stepped ramp type cylinder, and it is logical that the big section cylinder of top is equipped with internal screw thread half Hole punctures cylinder for screwing in screw thread with a scale, and the segment cylinder bottom of lower section is fixedly connected with sleeve-sliders, the sleeve-sliders Thickness matched with the orbit altitude of axial trajectory and circumferential track, it is axially sliding along C-shaped lantern ring in the axial trajectory Dynamic, in circumferential track except the circumferential direction sliding of C-shaped lantern ring, the internal screw thread half-via of the screw shell cylinder central axis The through-hole that the puncture hole size for being equipped with the central axial position for puncturing cylinder with the screw thread with a scale to position cooperates, and and C The hollow cavity of shape lantern ring is connected to, and it is the band cap that size is matched with the size of screw shell that the screw thread with a scale, which punctures cylinder, Bolt moulding, top are nut, and lower section is bolt, and the bolt is equipped with the internal screw thread half-via phase with the screw shell The socket external screw thread of cooperation, the side of the nut are fixedly connected with graduated scale, and the screw thread with a scale punctures cylinder and screws in spiral shell After line sleeve, the graduated scale is in outside screw shell.

2. tail intervertebral disc of rat microtrauma puncture injection and extraction element according to claim 1, it is characterised in that: described The first positioning grafting cylinder with a scale be up big and down small stepped ramp type cylinder, the track width of the segment diameter of axle and axial trajectory is matched It closes, bottom is fixedly connected with grafting cylinder sliding block, and the radial section of the axial trajectory is in " ten " font on C-shaped lantern ring, described Grafting cylinder sliding block sliding, transverse chambers of thickness and axial trajectory " ten " font along the transverse chambers body of axial trajectory " ten " font Body cooperation, and size is matched with the segment diameter of axle of the first positioning grafting cylinder with a scale, is axially simultaneously equipped with for positioning ginseng The scale mark examined.

3. the injection of the tail intervertebral disc of rat microtrauma puncture according to claim 2 and extraction element, it is characterised in that: described The first positioning grafting cylinder with a scale and grafting cylinder sliding block using integral type or using being screwed, be adhesively fixed that mode is fixed to be connected It connects, the scale mark is the scale hole of vertical equidistant arrangement, and the scale hole is connected to the first positioning pinholes.

4. tail intervertebral disc of rat microtrauma puncture injection and extraction element according to claim 1, it is characterised in that: described Second it is with a scale positioning patch cylinder be cylindrical, be directly fixedly connected with C-shaped collar body, equipped with the first band Scale positions the identical scale hole of grafting cylinder.

5. tail intervertebral disc of rat microtrauma puncture injection and extraction element according to claim 1, it is characterised in that: described Screw shell below segment cylinder bottom be fixedly connected with sleeve-sliders using being screwed or be adhesively fixed mode, it is described Graduated scale be equipped with vertical equidistant arrangement scale convex block.