CN209549490U - A kind of pharmaceutic adjuvant synthesis reaction vessel - Google Patents
A kind of pharmaceutic adjuvant synthesis reaction vessel Download PDFInfo
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- CN209549490U CN209549490U CN201920141709.1U CN201920141709U CN209549490U CN 209549490 U CN209549490 U CN 209549490U CN 201920141709 U CN201920141709 U CN 201920141709U CN 209549490 U CN209549490 U CN 209549490U
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- autoclave body
- reaction
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- pharmaceutic adjuvant
- synthesis reaction
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Abstract
The utility model belongs to chemical equipment technical field, more particularly to a kind of pharmaceutic adjuvant synthesis reaction vessel, it includes autoclave body, feed inlet, discharge port and agitating device, feed inlet is equipped at the top of autoclave body, discharge port is equipped in the lower end of the side wall of autoclave body, wherein, agitating device includes motor, shaft coupling and connect with motor that the intracorporal agitating shaft of kettle is driven and protruded by shaft coupling, temperature inductor is equipped in the lower part of agitating shaft, upper millstone is equipped in the bottom of agitating shaft, bottom inside autoclave body is equipped with lower millstone, is equipped with heating mantle in the lateral wall of autoclave body.Reaction kettle provided by the utility model, mill is equipped on bottom and agitating shaft inside autoclave body, temperature inductor is set in autoclave body, insoluble solid can be ground during the reaction, the temperature of monitoring reaction, improves reaction rate, reduces the generation of impurity while reaction, and can control reaction temperature variation will not too acutely improve production efficiency and product quality.
Description
Technical field
The utility model belongs to chemical equipment technical field, and in particular to a kind of pharmaceutic adjuvant synthesis reaction vessel.
Background technique
Pharmaceutic adjuvant is the basic material and important component of pharmaceutical preparation, is to guarantee pharmaceutical preparation production and development
Material base plays a key role in preparation formulation and production.It not only assigns drug certain dosage form.And with improve medicine
The curative effect of object, reduction adverse reaction have very big relationship, and reliability and diversity are to guarantee that dosage form and preparation are advanced
Basis.
Reaction kettle is the container physically or chemically reacted, by the structure design and parameter configuration to container, is realized
Heating, evaporation, cooling and the mix function that technique requires.Currently, during pharmacy and pharmaceutic adjuvant, some materials
Dissolubility is particularly poor, and reaction speed is very slow, and is easy to produce plurality of impurities, increases purification difficulty.
A kind of swing solid-liquid reaction kettle, including pedestal, branch are disclosed in China Patent Publication No. CN107983292 A
Foot, autoclave body, feed inlet, inlet tube and drain pipe, the top of the pedestal are equipped with autoclave body, and the inside of autoclave body is equipped with screw rod, screw rod
Left side be equipped with guide rod, the inside of autoclave body is equipped with sliding panel, and the lower surface of sliding panel is fixedly connected with first motor, the first electricity
The axle stretch end of machine is fixedly connected with shaft, and several broken swords are distributed in shaft, and the lower end of shaft is fixedly connected with abrasive disk, base
The upper surface of seat is fixedly connected with the second motor, and the axle stretch end of the second motor is fixedly connected with half bevel gear, the upper surface of pedestal
It is fixedly connected with third motor, the axle stretch end of third motor is fixedly connected with crank.Aforesaid reaction vessel is also provided with mill, and is grinding
The lower surface of disk is provided with equally distributed grinding convex body crushing solid reactant, still, the low efficiency of grinding, it is not easy to grind
Lesser solid reactant.
Therefore, often there is the non-uniform situation of material mixing in existing frequently-used solid-liquid reaction kettle, cause reaction efficiency low
Under, it is difficult to meet the daily production requirement of people.
Summary of the invention
The purpose of this utility model aiming at above-mentioned the deficiencies in the prior art, overcome the indissoluble material reaction time it is long,
Problem more than impurity, provides a kind of pharmaceutic adjuvant synthesis reaction vessel, the pharmaceutic adjuvant synthesis reaction vessel which provides,
It is equipped with mill on bottom and agitating shaft inside autoclave body, temperature inductor is set in autoclave body, it can during the reaction will be difficult
Molten solid is ground, and the temperature of control reaction, improves reaction rate while reaction, is shortened the reaction time, is reduced the life of impurity
At, and can control reaction temperature variation will not be too violent, improve production efficiency and product quality.
The technical solution adopted in the utility model is as follows: a kind of pharmaceutic adjuvant synthesis reaction vessel, it includes autoclave body, charging
Mouth, discharge port and agitating device are equipped with feed inlet at the top of autoclave body, are equipped with discharge port in the lower end of the side wall of autoclave body, wherein
Agitating device includes motor, shaft coupling and connect with motor that the intracorporal agitating shaft of kettle, In are driven and protruded by shaft coupling
The lower part of agitating shaft (9) is equipped with temperature inductor, and the bottom of agitating shaft is equipped with upper millstone, and the bottom inside autoclave body is equipped with lower mill
Disk is equipped with heating mantle in the lateral wall of autoclave body.
Pharmaceutic adjuvant synthesis reaction vessel provided by the utility model, the lower millstone being equipped with by the bottom inside autoclave body and is stirred
The interaction between the upper millstone that axis bottom is equipped with is mixed, grinds insoluble solid in auxiliary material synthetic reaction process, is improved anti-
Rate is answered, shortens the reaction time, reduces the generation of impurity.In a preferred embodiment, agitating device includes elevator, elevator
It connect with shaft coupling and moves up and down for adjusting agitating shaft, adjusting agitating shaft that when needed can be flexible and convenient is equipped with
Bottom inside upper millstone and autoclave body is equipped with the relative distance between lower millstone.
Pharmaceutic adjuvant synthesis reaction vessel provided by the utility model, autoclave body lateral wall be equipped with heating mantle, heating mantle with
The temperature inductor that the lower part of agitating shaft is equipped with passes through route respectively and connect with controller, when reaction temperature is higher, by temperature
Inductor feeds back to controller, stops heating mantle work, gradually decreases reaction temperature, when reaction temperature is lower, temperature sense
Device feeds back to controller again, and starting heating mantle work gradually rises temperature, therefore, can control while reaction anti-
The temperature answered improves reaction rate, shortens the reaction time, reduces the generation of impurity.
Solid reactant and liquid reactions material can also be added in this equipment simultaneously, in the charging that the top of autoclave body is equipped with
Solid reactant is added in mouth, while passing through inlet tube and liquid reactions material is added, wherein one end of inlet tube is by being fixed on
The pipe clamp at the top of autoclave body simultaneously protrudes into autoclave body, and the other end of inlet tube is equipped with flow control valve, flow control valve and charge pump
Connection.The flow control valve being arranged on inlet tube can control the speed that liquid reactions material is added, convenient for control reaction
Speed and the generation for reducing impurity.This equipment can be using the charge pump that can be realized charging purpose in the prior art, in one kind
In preferred embodiment, charge pump is anti-corrosion diaphragm pump, convenient for conveying the liquid reactions material with corrosive nature.
This equipment is removably equipped with blender on agitating shaft, is stirred reaction solution using blender, makes solid-liquid
Reaction mass is sufficiently mixed uniformly, keeps reaction more abundant.It is long-term during stirring to make since blender is vulnerable part
With being easy to wear, the utility model uses dismountable mode, is conveniently replaceable blender, is conducive to improve stirring efficiency, one
In kind preferred embodiment, blender is threadedly coupled with agitating shaft.The utility model can use can be realized stirring in the prior art
The blender of purpose, for example, blender is three leaf paddle of spiral.
In a preferred embodiment, multiple spray orifices are equipped with into the intracorporal inlet tube of kettle, when liquid reactions material passes through
When inlet tube enters pharmaceutic adjuvant synthesis reaction vessel, part reaction mass can be dispersed by the spray orifice that inlet tube is equipped with, kept away
Exempt from liquid reactions material and concentrated by the nozzle of inlet tube to be added in autoclave body, is unfavorable for solid reactant and liquid reactions material
It is sufficiently mixed.
Pharmaceutic adjuvant synthesis reaction vessel provided by the utility model is equipped with support frame in the bottom of autoclave body.
Pharmaceutic adjuvant synthesis reaction vessel provided by the utility model, agitating device are fixed on autoclave body by agitating device bracket
On.
The beneficial effects of the utility model have: pharmaceutic adjuvant synthesis reaction vessel provided by the utility model, inside autoclave body
Bottom and agitating shaft be equipped with mill, be provided with temperature inductor in autoclave body, can during the reaction grind insoluble solid
Broken, the temperature of control reaction, improves reaction rate while reaction, shortens the reaction time, reduces the generation of impurity, and can
It will not too acutely be improved production efficiency and product quality with controlling reaction temperature variation.
Detailed description of the invention
Fig. 1 is a kind of structural schematic diagram figure of the utility model；
Fig. 2 is another structural schematic diagram figure of the utility model；
Fig. 3 is the perspective view of the utility model Fig. 2；
Fig. 4 is the explosive view of the agitating device of the utility model；
In figure, 1 is autoclave body；2 be lower millstone；3 be upper millstone；4 be temperature inductor；5 be discharge port；6 be blender；61
It is agitating paddle；62 be screw；63 be blender base；7 be heating mantle；8 be spray orifice；9 be agitating shaft；91 be agitating shaft I；92 are
Agitating shaft II；10 be feed inlet；11 be motor；12 be flow control valve；13 be charge pump；14 be shaft coupling；15 be elevator；
16 be agitating device bracket；17 be pipe clamp；18 be support frame.
Specific embodiment
The utility model is further described with reference to the accompanying drawing:
As shown in Figure 1, Figure 2 and Figure 3, the utility model it include autoclave body 1, feed inlet 10, discharge port 5 and stirring dress
It sets, is equipped with feed inlet 10 at the top of autoclave body 1, be equipped with discharge port 5 in the lower end of the side wall of autoclave body 1, wherein agitating device includes
It motor 11, shaft coupling 14 and is connect with motor 11 and drives and protrude into the agitating shaft 9 in autoclave body 1 by shaft coupling 14, stirred
The lower part for mixing axis 9 is equipped with temperature inductor 4, and the bottom of agitating shaft is equipped with upper millstone (3), under the bottom inside autoclave body 1 is equipped with
Mill 2 is equipped with heating mantle 7 in the lateral wall of autoclave body.
As shown in Figure 1, Figure 2 and Figure 3, the upper millstone 3 that the lower millstone 2 and agitating shaft 9 that the bottom inside autoclave body 1 is equipped with are equipped with
Between interaction, insoluble solid is ground in auxiliary material synthetic reaction process, improve reaction rate, shorten the reaction time,
Reduce the generation of impurity.Wherein, agitating device includes elevator 15, and elevator 15 is connect with shaft coupling 14 for adjusting agitating shaft
9 move up and down, and the agitating shaft 9 that adjusts that when needed can be flexible and convenient is equipped with upper millstone 3 and the bottom inside autoclave body 1
Equipped with the relative distance between lower millstone 2.It is equipped with heating mantle 7 in the lateral wall of autoclave body 1, heating mantle 7 and the lower part of agitating shaft 9 are set
Some temperature inductors 4 are connect by route with controller respectively, when reaction temperature is higher, are fed back to by temperature inductor 4
Controller stops heating mantle work, gradually decreases reaction temperature, when reaction temperature is lower, temperature inductor 4 is fed back to again
Controller, starting heating mantle work, gradually rises temperature, thus it is possible to which the temperature that control is reacted while reaction, is improved
Reaction rate shortens the reaction time, reduces the generation of impurity.
As shown in Figures 2 and 3, solid reactant and liquid reactions material can be added in this equipment simultaneously, in autoclave body 1
Solid reactant is added in the feed inlet 10 that top is equipped with, while liquid reactions material is added by inlet tube, wherein inlet tube
One end by being fixed on the pipe clamp 17 at the top of autoclave body 1 and protruding into autoclave body 1, the other end of inlet tube is equipped with flow control valve
12, flow control valve 12 is connect with charge pump 13.It is anti-that the flow control valve 12 being arranged on inlet tube can control addition liquid
The speed of material is answered, convenient for the speed of control reaction and the generation of reduction impurity.This equipment, which can use, in the prior art can
Realize the charge pump of charging purpose, in figure 2 and figure 3, charge pump is anti-corrosion diaphragm pump, convenient for conveying the liquid with corrosive nature
Precursor reactant material.
As shown in Figures 2 and 3, the inlet tube into autoclave body 1 is equipped with multiple spray orifices 8, when liquid reactions material passes through
When inlet tube enters reaction kettle, part reaction mass can be dispersed by the spray orifice 8 that inlet tube is equipped with, avoid liquid reactants
Material is concentrated by the nozzle of inlet tube and is added in autoclave body 1, and being sufficiently mixed for solid reactant and liquid reactions material is unfavorable for.In
The bottom of autoclave body 1 is equipped with support frame 18, and agitating device is fixed on autoclave body 1 by agitating device bracket 16.
This equipment is removably equipped with blender 6 on agitating shaft 9, is stirred reaction solution using blender 6, makes solid
Liquid reactant is sufficiently mixed uniformly, keeps reaction more abundant.Since blender 6 is vulnerable part, during stirring for a long time
It is easily used to wear, as shown in figure 4, the utility model uses dismountable mode, is conveniently replaceable blender 6, be conducive to improve
Stirring efficiency, blender 6 are threadedly coupled with agitating shaft 9.The utility model can use can be realized stirring mesh in the prior art
Blender 6, for example, blender 6 be three leaf paddle of spiral.Agitating shaft 9 includes two parts, agitating shaft I 91 and agitating shaft II 92；
Blender 6 includes agitating paddle 61, screw 62 and blender base 20；One end of agitating shaft I 91 is equipped with screw thread, passes through agitating paddle 61
It is connect with being threadedly engaged for screw 62 that blender base 20 is equipped with.The both ends of agitating shaft II 92 are equipped with screw, agitating shaft II
92 one end passes through being threadedly engaged of being equipped with inside screw thread and blender base 63 on the screw that is equipped with and connect, agitating shaft II 92
The screw thread that passes through on the screw that is equipped with of the other end connect with being threadedly engaged for upper millstone 3.Temperature inductor 4 is set to agitating shaft
On II 92 side wall, lower millstone 2 is set to the bottom inside autoclave body 1, is used cooperatively with upper millstone 3, in auxiliary material synthetic reaction process
It is middle to grind insoluble solid, improve reaction rate.
The utility model use process is as follows:
Embodiment 1
Solid reactant and liquid reactions material are added in autoclave body 1 operator by feed inlet 10, and setting auxiliary material synthesizes
Start reaction kettle after the device parameters such as retarder 14 and elevator 15 in reaction kettle, drives blender 6 to stir solid-liquid by agitating shaft 9
Reaction mass, meanwhile, the lower millstone 2 that the upper millstone 3 that 9 bottom of agitating shaft is equipped with is equipped with the bottom inside autoclave body 1 is used cooperatively,
Insoluble solid is ground.9 lower part of agitating shaft is equipped with temperature inductor 4 and is fed back when reaction temperature is higher by temperature inductor 4
To controller, stops heating mantle work, gradually decrease reaction temperature, when reaction temperature is lower, temperature inductor 4 is fed back again
To controller, start heating mantle work, gradually rise temperature, the temperature of reaction can be controlled while reaction, is improved anti-
Rate is answered, shortens the reaction time, reduces the generation of impurity.To the end of reacting, it is discharged by discharge port 5.
Embodiment 2
Solid reactant is added in autoclave body 1 operator by feed inlet 10, and liquid reactions material is entered by charge pump 13
It is added in autoclave body 1, adjusts the speed that liquid reactions material is added in the control of flow control valve 12, be arranged in auxiliary material synthesis reaction vessel and subtract
Start reaction kettle after the device parameters such as fast device 14 and elevator 15, drive blender 6 to stir solid-liquid reaction material by agitating shaft 9,
Meanwhile the lower millstone 2 that the upper millstone 3 that is equipped with of the bottom of agitating shaft 9 is equipped with the bottom inside autoclave body 1 is used cooperatively, by indissoluble
Solid is ground.The lower part of agitating shaft 9 is equipped with temperature inductor 4 and feeds back to control by temperature inductor 4 when reaction temperature is higher
Device processed stops heating mantle work, gradually decreases reaction temperature, when reaction temperature is lower, temperature inductor 4 feeds back to control again
Device processed, starting heating mantle work, gradually rises temperature, and the temperature of reaction can be controlled while reaction, improves reaction speed
Rate shortens the reaction time, reduces the generation of impurity.To the end of reacting, it is discharged by discharge port 5.
The utility model relates to other undeclared parts it is same as the prior art.
It is obvious to a person skilled in the art that the details that the utility model is not limited to the above embodiments, and not
In the case where the spirit or essential attributes of the utility model, the utility model can be realized in other specific forms.Cause
This, in all respects, the present embodiments are to be considered as illustrative and not restrictive, the utility model
Range is indicated by the appended claims rather than the foregoing description, it is intended that by fall in the equivalent requirements of the claims meaning and
All changes in range are embraced therein.It should not treat any reference in the claims as involved by limitation
And claim.
In addition, it should be understood that although this specification is described in terms of embodiments, but not each embodiment is only wrapped
Containing an independent technical solution, this description of the specification is merely for the sake of clarity, and those skilled in the art should
It considers the specification as a whole, the technical solutions in the various embodiments may also be suitably combined, forms those skilled in the art
The other embodiments being understood that.
Claims (10)
1. a kind of pharmaceutic adjuvant synthesis reaction vessel, which is characterized in that it include autoclave body (1), feed inlet (10), discharge port (5) and
The top of agitating device, the autoclave body (1) is equipped with feed inlet (10), and the lower end of the side wall of the autoclave body (1) is equipped with discharge port
(5), the agitating device includes motor (11), shaft coupling (14) and is connect with the motor (11) through shaft coupling (14)
The agitating shaft (9) in the autoclave body (1) is driven and protrudes into, the lower part of the agitating shaft (9) is equipped with temperature inductor (4), described
The bottom of agitating shaft (9) is equipped with upper millstone (3), and the internal bottom of the autoclave body (1) is equipped with lower millstone (2), the autoclave body (1)
Lateral wall is equipped with heating mantle (7).
2. pharmaceutic adjuvant synthesis reaction vessel according to claim 1, which is characterized in that the agitating device includes elevator
(15), the elevator (15) connect with shaft coupling (14) moves up and down for adjusting agitating shaft (9).
3. pharmaceutic adjuvant synthesis reaction vessel according to claim 2, which is characterized in that one end of inlet tube is by being fixed on
The pipe clamp (17) at the top of the autoclave body (1) simultaneously protrudes into the autoclave body (1), and the other end of inlet tube is equipped with flow control valve
(12), the flow control valve (12) connect with charge pump (13).
4. pharmaceutic adjuvant synthesis reaction vessel according to claim 1,2 or 3, which is characterized in that can on the agitating shaft (9)
Disassembly is equipped with blender (6).
5. pharmaceutic adjuvant synthesis reaction vessel according to claim 4, which is characterized in that the blender (6) and agitating shaft
(9) it is threadedly coupled.
6. pharmaceutic adjuvant synthesis reaction vessel according to claim 5, which is characterized in that the blender (6) is spiral three
Leaf paddle.
7. pharmaceutic adjuvant synthesis reaction vessel according to claim 3, which is characterized in that enter the inlet tube in autoclave body (1)
It is equipped with multiple spray orifices (8).
8. pharmaceutic adjuvant synthesis reaction vessel according to claim 4, which is characterized in that the agitating device passes through stirring dress
Bracket (16) is set to be fixed on the autoclave body (1).
9. pharmaceutic adjuvant synthesis reaction vessel according to claim 3, which is characterized in that the charge pump (13) be anti-corrosion every
Membrane pump.
10. pharmaceutic adjuvant synthesis reaction vessel according to claim 4, which is characterized in that the bottom of the autoclave body (1) is equipped with
Support frame (18).
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| Application Number | Priority Date | Filing Date | Title |
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| CN201920141709.1U CN209549490U (en) | 2019-01-28 | 2019-01-28 | A kind of pharmaceutic adjuvant synthesis reaction vessel |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201920141709.1U CN209549490U (en) | 2019-01-28 | 2019-01-28 | A kind of pharmaceutic adjuvant synthesis reaction vessel |
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| CN209549490U true CN209549490U (en) | 2019-10-29 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112657457A (en) * | 2021-01-28 | 2021-04-16 | 盐城仁恒化工有限公司 | Equipment and method for preparing anhydrous ethylenediamine from ethylenediamine hydrochloride |
-
2019
- 2019-01-28 CN CN201920141709.1U patent/CN209549490U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112657457A (en) * | 2021-01-28 | 2021-04-16 | 盐城仁恒化工有限公司 | Equipment and method for preparing anhydrous ethylenediamine from ethylenediamine hydrochloride |
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