CN117816102B - Medical intermediate synthesis device and application method thereof - Google Patents
Medical intermediate synthesis device and application method thereof Download PDFInfo
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- CN117816102B CN117816102B CN202410233899.5A CN202410233899A CN117816102B CN 117816102 B CN117816102 B CN 117816102B CN 202410233899 A CN202410233899 A CN 202410233899A CN 117816102 B CN117816102 B CN 117816102B
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- 238000003786 synthesis reaction Methods 0.000 title claims abstract description 86
- 230000015572 biosynthetic process Effects 0.000 title claims abstract description 81
- 238000000034 method Methods 0.000 title claims abstract description 29
- 238000000227 grinding Methods 0.000 claims abstract description 90
- 239000002994 raw material Substances 0.000 claims abstract description 82
- 230000007246 mechanism Effects 0.000 claims abstract description 56
- 238000003756 stirring Methods 0.000 claims abstract description 28
- 238000010438 heat treatment Methods 0.000 claims abstract description 12
- 239000003814 drug Substances 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 87
- 238000003860 storage Methods 0.000 claims description 45
- 239000000543 intermediate Substances 0.000 claims description 20
- 238000007599 discharging Methods 0.000 claims description 16
- 239000012450 pharmaceutical intermediate Substances 0.000 claims description 12
- 230000008569 process Effects 0.000 abstract description 15
- 238000006243 chemical reaction Methods 0.000 abstract description 13
- 238000004519 manufacturing process Methods 0.000 abstract description 9
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- 230000009257 reactivity Effects 0.000 abstract description 3
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- 238000002156 mixing Methods 0.000 description 6
- 239000000825 pharmaceutical preparation Substances 0.000 description 6
- 229940127557 pharmaceutical product Drugs 0.000 description 4
- 239000002245 particle Substances 0.000 description 3
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- 239000000376 reactant Substances 0.000 description 3
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- 150000001875 compounds Chemical class 0.000 description 2
- 238000012864 cross contamination Methods 0.000 description 2
- 229940126534 drug product Drugs 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000002246 antineoplastic agent Substances 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
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- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
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Abstract
The invention relates to the technical field of medicine production equipment, in particular to a medicine intermediate synthesis device and a use method thereof, wherein the synthesis device comprises a synthesis tank body, a stirring mechanism and a raw material grinding mechanism, the stirring mechanism is arranged in the synthesis tank body, the raw material grinding mechanism is connected to one side of the synthesis tank body, and an observation window is formed in the synthesis tank body; the top fixedly connected with apron of synthetic jar body is provided with driving motor A in the upper end of apron, is provided with the delivery pipe at the lower extreme of synthetic jar body, and driving motor A's output is connected with the rabbling mechanism drive each other. The invention can finely grind the raw materials through the grinding column in the raw material grinding mechanism, which is beneficial to improving the reactivity and the solubility of the raw materials, thereby improving the effect of the synthesis reaction; the heating coils arranged on the inner wall of the synthesis tank body can control the temperature in the synthesis process, ensure the reaction temperature to be in a proper range, and improve the efficiency and the selection of the synthesis reaction.
Description
Technical Field
The invention relates to the technical field of medicine production equipment, in particular to a medicine intermediate synthesis device and a use method thereof.
Background
Currently, pharmaceutical intermediates refer to intermediate compounds obtained after a certain chemical or biological conversion reaction in the process of manufacturing medicines. These compounds are generally not the final pharmaceutical products, but they are an important component necessary for the manufacture of pharmaceutical products, and pharmaceutical intermediates have high purity and stability to ensure the quality and safety of the final pharmaceutical products. Generally, the process of manufacturing a drug product generally starts with a raw material, and the raw material is converted into various intermediates through a plurality of processes, so that a desired drug product is finally formed. Pharmaceutical intermediates are very diverse and can be classified into various classes such as amino acids, saccharides, fatty acids, vitamins, hormones, antibiotics, antitumor agents, etc., according to their structures and uses. Different pharmaceutical products may require different intermediates for manufacture, and thus pharmaceutical intermediates also have great diversity in preparation and use.
At present, raw materials are required to be ground in the production process of medical intermediates, the raw materials are ground into fine particles, but traditional grinding equipment in the prior art cannot be used for feeding materials simultaneously in the grinding process, so that the repeated feeding process can be carried out, the grinding process is long in time consumption, the overall production efficiency is influenced, the raw materials are difficult to be sufficiently stirred and mixed by stirring equipment in the subsequent mixing process, and the uniformity and quality of a final product are influenced.
There is a need for a pharmaceutical intermediate synthesis apparatus and method of use that can solve the above problems.
Disclosure of Invention
The invention aims to provide a medical intermediate synthesis device and a use method thereof, wherein the raw materials can be finely ground through a grinding column in a raw material grinding mechanism, so that the reactivity and the solubility of the raw materials can be improved, and the effect of synthesis reaction is improved; the heating coils arranged on the inner wall of the synthesis tank body can control the temperature in the synthesis process, ensure the reaction temperature to be in a proper range, and improve the efficiency and the selection of the synthesis reaction.
The technical scheme adopted by the invention for solving the technical problems is as follows: the medicine intermediate synthesis device comprises a synthesis tank body, a stirring mechanism and a raw material grinding mechanism, wherein the stirring mechanism is arranged in the synthesis tank body, the raw material grinding mechanism is connected to one side of the synthesis tank body, and an observation window is formed in the synthesis tank body;
the top of the synthesis tank body is fixedly connected with a cover plate, the upper end of the cover plate is provided with a driving motor A, the lower end of the synthesis tank body is provided with a water supply pipe, the output end of the driving motor A is in driving connection with the stirring mechanism, the water supply pipe is communicated with the synthesis tank body, one side of the synthesis tank body is provided with a water supply mechanism, and the water supply mechanism is connected with the synthesis tank body through a water inlet pipe;
The heating coil is wound on the inner wall of the synthesis tank body, one end of the heating coil is connected with the plug through a connecting wire B, a discharge hole is formed in the bottom of the synthesis tank body, a discharge pipe is fixedly connected to the lower end of the synthesis tank body, the discharge pipe is communicated with the discharge hole, and a storage tank is connected to the lower end of the discharge pipe;
The raw material grinding mechanism is arranged at the upper end of the supporting vertical seat and comprises a grinding column, a feeding tank, a discharging disc, a driving motor B and a grinding seat, wherein the driving motor B is connected to one side of the upper end of the supporting vertical seat through a fixed support B, the output end of the driving motor B is in driving connection with a rotating rod A, the grinding column is connected to the bottom of the rotating rod A, the grinding seat is arranged at the lower end of the grinding column, and the grinding seat is connected with the synthetic tank body through a feeding pipe;
The feeding tank is fixedly connected to one side of the supporting vertical seat through a fixing support A, the bottom of the feeding tank is connected with a conveying hopper, one end of the conveying hopper extends into the discharging disc, the discharging disc is connected with a plurality of feeding pipes through a plurality of connecting rods and a rotating rod A, and the feeding pipes are arranged on the outer side of the grinding seat along the circumferential direction.
Further, rabbling mechanism includes rotary drum, bull stick B and many agitator disks, mutual drive connection between rotary drum and the driving motor A, bull stick B is provided with two, and two bull sticks B are fixed connection respectively on the rotary drum, and many agitator disks are equal fixed connection between two bull sticks B.
Further, the water supply mechanism comprises a water storage tank, a water supply pipe and a water pump, wherein the water storage tank is arranged on one side of the water storage tank, the water supply pipe is connected to one side of the lower portion of the water storage tank, the water pump is connected to the water supply pipe, a control valve is arranged on the water supply pipe, and the water supply pipe is mutually communicated with the water inlet pipe.
Further, a supporting stand is arranged on one side of the water storage tank, a storage battery is installed at the upper end of the supporting stand, and the storage battery is connected with the driving motor A through a connecting wire A.
Further, a fixed disk B is fixedly connected to the bottom of the synthetic tank body, a fixed disk A is fixedly connected to the outer edge of the discharging pipe, and the fixed disk A and the fixed disk B are fixedly connected with each other through bolts.
Further, the grinding seat is fixedly connected with a grinding plate, and a plurality of through holes are formed in the grinding plate.
Further, a plurality of supporting plates are fixedly connected to the outer side wall of the storage tank.
The application method of the medical intermediate synthesis device comprises the following steps:
Step S1: the method comprises the steps that raw materials of medical intermediates to be mixed are placed in a feeding tank, a driving motor B is started, the driving motor B drives a rotating rod A to rotate simultaneously, the rotating rod A enables a discharging disc to do circular motion through a connecting rod, raw materials in the feeding tank fall into a grinding seat through a feeding pipe, and the raw materials are ground through a grinding column;
Step S2: starting driving motor A and water pump after the raw materials after grinding enters into the synthetic jar body through the inlet pipe, the water pump pours into the inside of the synthetic jar body through the inlet tube with the water in the water storage jar, driving motor A drives the rotary drum and rotates, and the rotary drum drives two bull sticks B simultaneously and rotates, carries out intensive mixing to raw materials and water through the agitator disk of installing on the bull stick B, and the raw materials after mixing is discharged to the storage jar through discharge gate and discharging pipe and is stored.
The invention has the advantages that: the invention provides a medical intermediate synthesis device and a use method thereof, and the invention has the following advantages:
1. automatic uniform synthesis: according to the invention, through the coordination of the stirring mechanism, the raw material grinding mechanism and the water supply mechanism, the automatic mixing and synthesis of the medical intermediate are realized, the manual operation requirement is reduced, the production efficiency is improved, and the raw materials and the water can be fully mixed by the rotary drum, the rotary rod B and the stirring disc structure of the stirring mechanism, so that the uniformity of the medical intermediate is ensured, and the product quality is improved.
2. Fine grinding: according to the invention, the raw materials can be finely ground through the grinding column in the raw material grinding mechanism, so that the reactivity and the solubility of the raw materials are improved, the mixing uniformity and the reaction rate in the subsequent synthesis process are improved, the synthesis effect is improved, the raw materials can continuously fall down, new raw materials can be timely supplemented in the grinding process, the grinding efficiency is improved, and the ground raw materials are fed into the synthesis tank body through the independent raw material grinding mechanism and the feeding pipe, so that the possibility of cross contamination is reduced.
3. And (3) temperature control: the heating coils arranged on the inner wall of the synthesis tank body can control the temperature in the synthesis process, ensure the reaction temperature to be in a proper range, and improve the efficiency and selectivity of the synthesis reaction.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings that are needed in the description of the embodiments or the prior art will be briefly described, and it is obvious that the drawings in the description below are some embodiments of the present invention, and other drawings can be obtained according to the drawings without inventive effort for a person skilled in the art.
FIG. 1 is a schematic perspective view of the present invention;
FIG. 2 is a schematic diagram of the internal structure of the synthesis tank according to the present invention;
FIG. 3 is a schematic view of a raw material grinding mechanism according to the present invention;
FIG. 4 is a schematic view of the other side of the raw material grinding mechanism according to the present invention;
FIG. 5 is an enlarged schematic view of the grinding column of the raw material grinding mechanism according to the present invention;
FIG. 6 is an enlarged view of the polishing pad according to the present invention;
Wherein:
1. synthesizing a tank body; 2. A cover plate; 3. A driving motor A;
4. an observation window; 5.A storage tank; 6. A supporting pallet;
7. A supporting stand; 8. A storage battery; 9. A connecting wire A;
10. A water storage tank; 11. A water supply pipe; 12. A water pump;
13. a control valve; 14. A water inlet pipe; 15. A connecting wire B;
16. a plug; 17. A supporting vertical seat; 18. A raw material grinding mechanism;
1801. A fixed bracket A; 1802. Grinding the column; 1803. A rotating rod A;
1804. a connecting rod; 1805. A feed tank; 1806. A feed hopper;
1807. a discharge tray; 1808. A grinding seat; 1809. A feed pipe;
1810. A grinding plate; 1811. A driving motor B; 1812. A fixed bracket B;
19. a feed pipe; 20. A discharge pipe; 21. A fixed disk A;
22. A fixed disk B; 23. A rotating drum; 24. A rotating rod B;
25. A stirring plate; 26. A heating coil; 27. And a discharge port.
Detailed Description
The following description of the embodiments of the present invention will be made apparent and fully in view of the accompanying drawings, in which some, but not all embodiments of the invention are shown. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
In the description of the present invention, it should be noted that unless explicitly stated and limited otherwise, the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc. indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, are merely for convenience in describing the present invention and simplifying the description, and do not indicate or imply that the devices or elements referred to must have a specific orientation, be configured and operated in a specific orientation, and thus should not be construed as limiting the present invention. Furthermore, the terms "first," "second," "third," and the like, are used for descriptive purposes only and are not to be construed as indicating or implying relative importance, but rather the terms "mounted," "connected," and the like are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; can be directly connected or indirectly connected through an intermediate medium, and can be communication between two elements. The specific meaning of the above terms in the present invention will be understood in specific cases by those of ordinary skill in the art.
Example 1: fig. 1 is a schematic perspective view of a structure of a synthesis tank according to the present invention, fig. 2 is a schematic view of an internal structure of the synthesis tank according to the present invention, fig. 3 is a schematic view of a structure of a raw material grinding mechanism according to the present invention, fig. 4 is a schematic view of an enlarged structure of a grinding column of the raw material grinding mechanism according to the present invention, fig. 6 is an enlarged structure of a grinding seat according to the present invention, as shown in fig. 1, fig. 2, fig. 3, fig. 4, fig. 5 and fig. 6, a pharmaceutical intermediate synthesis device includes a synthesis tank 1, a stirring mechanism and a raw material grinding mechanism 18, wherein the stirring mechanism is installed in the synthesis tank 1, the raw material grinding mechanism 18 is connected to one side of the synthesis tank 1, the synthesis tank 1 is used for storing a reactant and a synthesis intermediate, and provides a reaction space and a reaction pressure tolerance in the synthesis process, and an observation window 4 is provided on the synthesis tank 1, so that a synthesis condition of raw materials in the synthesis tank 1 is convenient to be observed and a reaction condition is convenient to be adjusted in time;
the invention fixedly connects with cover plate 2 at the top of the synthetic tank 1, cover plate 2 covers the top of synthetic tank 1, prevent the reactant from overflowing, keep the reaction environment stable, there are driving motors A3 in the upper end of cover plate 2, there are water supply pipes 11 in the lower end of synthetic tank 1, drive the output end of the motor A3 to connect with said stirring mechanism mutually, the water supply pipe 11 is communicated with synthetic tank 1 each other, used for driving the stirring mechanism to stir, one side of said synthetic tank 1 has water supply mechanisms, water supply mechanism and synthetic tank 1 are connected each other through the water inlet pipe 14, the water supply mechanism is used for sending the water in the water storage tank 10 into synthetic tank 1, thus provide the water source needed by reaction, the water supply mechanism in the invention includes water storage tank 10, water supply pipe 11 and water pump 12, there are support stands 7 in one side of the water storage tank 10, install the battery 8 in the upper end of the support stands 7, connect with said driving motor A3 each other through the connecting wire A9, the battery 8 is used for supplying power to the driving motor A3, one side of said water storage pipe 10 is set up in the invention, connect with water supply pipe 11 in the water storage tank 11 with said water storage tank 11 through the water inlet pipe 14, can be connected with water storage tank 11 in order to make water storage tank 11 and water storage 11 in the water storage tank 11 in order to provide the water storage tank 14; the stirring mechanism comprises a rotary drum 23, rotary rods B24 and a plurality of stirring discs 25, wherein the rotary drum 23 is in driving connection with a driving motor A3, the rotary drum 23 is used for driving the two rotary rods B24 to rotate, the two rotary rods B24 are respectively and fixedly connected to the rotary drum 23, the plurality of stirring discs 25 are fixedly connected between the two rotary rods B24 and can rotate together with the rotary drum 23, and reactants in a stirring tank body are fully and uniformly synthesized and uniformly mixed under the rotation of the two rotary rods B24 and the plurality of stirring discs 25, so that the reaction is promoted, and the reaction efficiency is improved.
According to the invention, a heating coil 26 is wound on the inner wall of a synthesis tank body 1, heating conditions required by reaction can be provided through the heating coil 26, one end of the heating coil 26 is connected with a plug 16 through a connecting wire B15, the plug 16 is used for connecting an external power supply, a discharge hole 27 is formed in the bottom of the synthesis tank body 1 and used for discharging mixed raw materials from the bottom of the synthesis tank body 1, a discharge pipe 20 is fixedly connected to the lower end of the synthesis tank body 1, the discharge pipe 20 is communicated with the discharge hole 27 and used for conveying the raw materials into a storage tank 5, a fixed disc B22 is fixedly connected to the bottom of the synthesis tank body 1, a fixed disc A21 is fixedly connected to the outer edge of the discharge pipe 20 through a bolt, the fixed disc A21 and the fixed disc B22 play a role of enhancing the connection strength between the discharge pipe 20 and the synthesis tank body 1, a plurality of supporting pallets 6 are fixedly connected to the outer side wall of the storage tank 5 through the fixed disc A21 and the fixed disc B22, and the storage tank 5 is firmly supported by the supporting pallets 6, and the raw materials are discharged into the storage tank 5 through the storage tank 5 after being firmly supported by the supporting the storage tank 5;
The raw material grinding mechanism 18 is arranged at the upper end of the supporting stand 17, the raw material grinding mechanism 18 comprises a grinding column 1802, a feeding tank 1805, a discharging tray 1807, a driving motor B1811 and a grinding seat 1808, wherein the driving motor B1811 is connected to one side of the supporting stand 17 through a fixed bracket B1812, the output end of the driving motor B1811 is in driving connection with a rotating rod A1803, a lifting rod connected with the grinding column 1802 is arranged in the rotating rod A1803, the grinding column 1802 is connected to the bottom of the rotating rod A1803, the grinding column 1802 is used for compressing part of the agglomerated solid raw material downwards so as to grind the solid raw material into particles with proper size through the grinding plate 1810, the lifting rod in the rotating rod A1803 can drive the grinding column 1802 to lift, the grinding seat 1808 is arranged at the lower end of the grinding column 1802, and the grinding seat 1808 and the synthetic tank 1 are mutually connected through a feeding pipe 19; the feeding tank 1805 is fixedly connected to one side of the supporting stand 17 through a fixed bracket A1801, the bottom of the feeding tank 1805 is connected with a delivery hopper 1806, one end of the delivery hopper 1806 extends into the discharge tray 1807, the feeding tank 1805 is used for storing raw materials, the raw materials are conveyed by the delivery hopper 1806, the raw materials are conveyed by a conveying pipe 1809, the raw materials are ground by a grinding seat 1808 conveyed by a grinding column 1802, the discharge tray 1807 is connected with the rotating rod A1803 through a plurality of connecting rods 1804, the discharge tray 1807 can rotate under the driving of the rotating rod A1803, a plurality of conveying pipes 1809 are connected to the bottom of the discharge tray 1807, the conveying pipes 1809 are arranged outside the grinding seat 1808 along the circumferential direction, the raw materials grinding mechanism 18 can grind solid raw materials into particles with proper size, so as to mix more quickly and fully in the synthesis process, raw materials in a feed tank 1805 in a raw material grinding mechanism 18 can continuously fall down, fall into a grinding seat 1808 through a discharge plate 1807 and a feed pipe 1809, grind raw materials through a grinding column 1802, a grinding plate 1810 is fixedly connected to the inside of the grinding seat 1808, a plurality of through holes are formed in the grinding plate 1810, the grinded raw materials fall into a feed pipe 19 through the through holes, the grinded raw materials are fed into a synthesis tank 1 through the feed pipe 19, the possibility of cross contamination is reduced, the raw materials in the feed tank 1805 fall into the discharge plate 1807, fall into the grinding seat 1808 through the feed pipe 1809, grind the raw materials through the grinding column 1802, and new raw materials can be timely supplemented in the grinding process through the mechanism, so that the grinding efficiency is improved.
Example 2: the invention also discloses a using method of the medical intermediate synthesis device, which comprises the following steps:
Step S1: the pharmaceutical intermediate materials to be mixed are first placed in a feed tank 1805. Then, a driving motor B1811 is started, the driving motor B1811 is started by putting the raw materials of the medical intermediates to be mixed into a feeding tank 1805, the driving motor B1811 drives a rotating rod A1803 to rotate simultaneously, the rotating rod A1803 enables a discharging disc 1807 to do circular motion through a connecting rod 1804, the raw materials in the feeding tank 1805 enter the discharging disc 1807 through a feeding hopper 1806, the raw materials fall into a grinding seat 1808 through a feeding pipe 1809 connected with the lower end of the discharging disc 1807, and a grinding column 1802 grinds the raw materials to achieve the required fineness; the main purpose of this step is to grind the raw materials to a particle size suitable for subsequent processing to improve the reaction efficiency and product quality of the raw materials.
Step S2: the ground raw material enters the synthesis tank 1 through a feed pipe 19. At this time, the drive motor A3 and the water pump 12 are started. The water pump 12 injects water in the water storage tank 10 into the interior of the synthesis tank 1 through the water inlet pipe 14. At the same time, the driving motor A3 drives the rotary drum 23 to rotate, and the two rotating rods B24 on the rotary drum 23 also rotate. These two rotating rods B24 are provided with stirring discs 25, which allow the raw materials and water to be thoroughly mixed. The mixed raw materials are finally discharged to the storage tank 5 for storage through the discharge port 27 and the discharge pipe 20; the main purpose of this step is to uniformly mix the ground raw material with water to form the final product. By stirring with the stirring plate 25, the raw materials and water can be ensured to be fully contacted, and the uniformity of mixing can be improved, thereby improving the quality of the product.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and not for limiting the same; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical scheme described in the foregoing embodiments can be modified or some or all of the technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit of the invention.
Claims (7)
1. The utility model provides a medicine intermediate synthesizer, includes synthesis jar body (1), rabbling mechanism and raw materials grinding mechanism (18), the rabbling mechanism is installed in the inside of synthesis jar body (1), raw materials grinding mechanism (18) are connected in one side of synthesis jar body (1), have seted up observation window (4) on synthesis jar body (1);
The method is characterized in that: the top of the synthesis tank body (1) is fixedly connected with a cover plate (2), a driving motor A (3) and a water supply pipe (11) are arranged at the upper end of the cover plate (2), the output end of the driving motor A (3) is in driving connection with the stirring mechanism, the water supply pipe (11) is communicated with the synthesis tank body (1), a water supply mechanism is arranged on one side of the synthesis tank body (1), and the water supply mechanism is connected with the synthesis tank body (1) through a water inlet pipe (14);
The heating coil (26) is wound on the inner wall of the synthesis tank body (1), one end of the heating coil (26) is connected with the plug (16), the bottom of the synthesis tank body (1) is provided with the discharge hole (27) B, the lower end of the synthesis tank body (1) is fixedly connected with the discharge pipe (20), the discharge pipe (20) and the discharge hole (27) B are communicated with each other, and the lower end of the discharge pipe (20) is connected with the storage tank (5);
The raw material grinding mechanism (18) is arranged at the upper end of the supporting vertical seat (17), the raw material grinding mechanism (18) comprises a grinding column (1802), a feeding tank (1805), a discharging disc (1807), a driving motor B (1811) and a grinding seat (1808), the driving motor B (1811) is connected to one side of the upper end of the supporting vertical seat (17) through a fixing bracket B (1812), the output end of the driving motor B (1811) is in driving connection with a rotating rod A (1803), the grinding column (1802) is connected to the bottom of the rotating rod A (1803), the grinding seat (1808) is arranged at the lower end of the grinding column (1802), and the grinding seat (1808) and the synthetic tank (1) are connected with each other through a feeding pipe (19);
the feeding tank (1805) is fixedly connected to one side of the supporting vertical seat (17) through a fixing support A (1801), a conveying hopper (1806) is connected to the bottom of the feeding tank (1805), one end of the conveying hopper (1806) stretches into the discharging disc (1807), the discharging disc (1807) is connected with the rotating rod A (1803) through a plurality of connecting rods (1804), a plurality of feeding pipes (1809) are connected to the bottom of the discharging disc (1807), and the feeding pipes (1809) are arranged on the outer side of the grinding seat (1808) along the circumferential direction;
the inside of grinding seat (1808) is fixedly connected with grinding plate (1810), has seted up a plurality of through-holes on grinding plate (1810).
2. A pharmaceutical intermediate synthesis apparatus according to claim 1, wherein: the stirring mechanism comprises a rotary drum (23), a rotary rod B (24) and a plurality of stirring discs (25), wherein the rotary drum (23) and a driving motor A (3) are in driving connection with each other, the rotary rod B (24) is provided with two rotary rods, the two rotary rods B (24) are respectively and fixedly connected to the rotary drum (23), and the stirring discs (25) are fixedly connected between the two rotary rods B (24).
3. A pharmaceutical intermediate synthesis apparatus according to claim 1, wherein: the water supply mechanism comprises a water storage tank (10), a water supply pipe (11) and a water pump (12), wherein the water storage tank (10) is arranged on one side of the water storage tank (5), the water supply pipe (11) is connected to one side of the lower portion of the water storage tank (10), the water pump (12) is connected to the water supply pipe (11), a control valve (13) is arranged on the water supply pipe (11), and the water supply pipe (11) and the water inlet pipe (14) are mutually communicated.
4. A pharmaceutical intermediate synthesis apparatus according to claim 3, wherein: one side of the water storage tank (10) is provided with a supporting vertical frame (7), a storage battery (8) is arranged at the upper end of the supporting vertical frame (7), and the storage battery (8) and the driving motor A (3) are connected with each other through a connecting wire (9).
5. A pharmaceutical intermediate synthesis apparatus according to claim 1, wherein: the bottom of the synthesis tank body (1) is fixedly connected with a fixed disk B (22), the outer edge of the discharge pipe (20) is fixedly connected with a fixed disk A (21), and the fixed disk A (21) and the fixed disk B (22) are fixedly connected with each other through bolts.
6. A pharmaceutical intermediate synthesis apparatus according to claim 1, wherein: and a plurality of supporting plates (6) are fixedly connected to the outer side wall of the storage tank (5).
7. The application method of the medical intermediate synthesis device is characterized by comprising the following steps of: the method comprises the following steps:
Step S1: the method comprises the steps that raw materials of medical intermediates to be mixed are placed into a feeding tank (1805), a driving motor B (1811) is started, the driving motor B (1811) drives a rotating rod A (1803) to rotate simultaneously, the rotating rod A (1803) enables a discharging disc (1807) to do circular motion through a connecting rod (1804), raw materials in the feeding tank (1805) fall into a grinding seat (1808) through a feeding pipe (1809), and the raw materials are ground through a grinding column (1802);
Step S2: after the ground raw materials enter the synthesis tank body (1) through a feed pipe (19), a driving motor A (3) and a water pump (12) are started, water in a water storage tank (10) is injected into the synthesis tank body (1) through a water inlet pipe (14) by the water pump (12), the driving motor A (3) drives a rotary drum (23) to rotate, the rotary drum (23) simultaneously drives two rotary rods B (24) to rotate, the raw materials and the water are fully mixed through a stirring disc (25) arranged on the rotary rods B (24), and the mixed raw materials are discharged into a storage tank (5) through a discharge hole (27) and a discharge pipe (20) to be stored.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410233899.5A CN117816102B (en) | 2024-03-01 | 2024-03-01 | Medical intermediate synthesis device and application method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410233899.5A CN117816102B (en) | 2024-03-01 | 2024-03-01 | Medical intermediate synthesis device and application method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN117816102A CN117816102A (en) | 2024-04-05 |
| CN117816102B true CN117816102B (en) | 2024-05-28 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202410233899.5A Active CN117816102B (en) | 2024-03-01 | 2024-03-01 | Medical intermediate synthesis device and application method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN207667192U (en) * | 2017-09-26 | 2018-07-31 | 安徽科正检测有限公司 | A kind of Chinese medicine extractor |
| WO2022110296A1 (en) * | 2020-11-30 | 2022-06-02 | 射阳县射阳港红太阳饲料厂 | Crushing device for feed production and processing |
| WO2023284605A1 (en) * | 2021-07-14 | 2023-01-19 | 安徽雷鸣科化有限责任公司 | Plc-controlled emulsification device for emulsion explosive test and working method of same |
| CN116603410A (en) * | 2023-04-24 | 2023-08-18 | 安徽广信农化股份有限公司 | Diuron granule high-suspension-rate preparation device and method |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN207667192U (en) * | 2017-09-26 | 2018-07-31 | 安徽科正检测有限公司 | A kind of Chinese medicine extractor |
| WO2022110296A1 (en) * | 2020-11-30 | 2022-06-02 | 射阳县射阳港红太阳饲料厂 | Crushing device for feed production and processing |
| WO2023284605A1 (en) * | 2021-07-14 | 2023-01-19 | 安徽雷鸣科化有限责任公司 | Plc-controlled emulsification device for emulsion explosive test and working method of same |
| CN116603410A (en) * | 2023-04-24 | 2023-08-18 | 安徽广信农化股份有限公司 | Diuron granule high-suspension-rate preparation device and method |
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| CN117816102A (en) | 2024-04-05 |
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