CN209421888U - Convey the device of medicament - Google Patents

Convey the device of medicament Download PDF

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Publication number
CN209421888U
CN209421888U CN201821858909.0U CN201821858909U CN209421888U CN 209421888 U CN209421888 U CN 209421888U CN 201821858909 U CN201821858909 U CN 201821858909U CN 209421888 U CN209421888 U CN 209421888U
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Prior art keywords
cavity
medicament
container
pressure
outlet
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CN201821858909.0U
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杨玉民
杨杨
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ZHEJIANG SANCHUANG BIOTECHNOLOGY Co Ltd
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ZHEJIANG SANCHUANG BIOTECHNOLOGY Co Ltd
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Abstract

A kind of device conveying medicament, including voltage regulation part, the voltage regulation part include pressure regulating cavity, and one end opening, for being connected with conduit, the cavity wall of other end opening and the axial angle of pressure regulating cavity are 3 °~10 °.The form that device provided by the utility model can be mitigated with more stable and lasting balanced propulsion mode and more implements conveying to the medicament in container, effectively avoids pressure from discharging suddenly and medicament is made to be covered with the hysteroscope visual field by the reaction of target tissue, make to be administered (such as: hemostat) more accurately, the continuity of endoscope-assistant surgery operation is improved simultaneously, haemostatic effect is improved, operation time is shortened.

Description

Convey the device of medicament
Technical field
The utility model relates to a kind of administration containers, more particularly to one kind to be driven by pressure source and medicament is delivered to target group The device knitted, so that medicament plays therapeutic effect in target tissue.
Background technique
At present for wound hemorrhage caused by wound or operation, no matter too busy to get away " compressing stops using which kind of hemostatic technique The conventional means of blood ".It is common such as: styptic sponge, hemostasis used in adhesive bandage that external wound uses and various operations Microballoon, hemostatic medical film and without hemostatic yarn made of spinning process etc..Although these hemostatic techniques effectively increase hemostasis efficiency, but External force is removed again after all must first oppressing a period of time, and observes whether site of injury still has blutpunkte.If there is bleeding, then need Hemostat is continued to use, and is oppressed again, until reaching hemostasis.Not only operate it is complicated, dependent on artificial judgement, for deep layer reality The hemostasis of matter internal organs and the cavity deep layer surface of a wound is difficult to exact operations, causes anthemorrhagic difficulty, especially needs to these positions or tissue Long-time local compression and stop blooding, be unfavorable for wound later period healing.Such as: nasal sinus or nasal cavity generally use expanded tampon at present Sponge, hemostasis are not easy thoroughly, and observation further takes out styptic sponge without bleeding after need to oppressing 24 hours.The swelling of patient's nose, respiratory tract It is unsmooth, the timely anthemorrhagic difficulty of operation is also resulted in, life in patients is poor, observes and needs second within 24 hours and take out, increases medical matters The workload of worker.
The appearance of hemostasis gel, so that wound hemostasis is improved.But wound biggish for amount of bleeding, hemostasis gel It is difficult to be adhered to wound in a short time, is not so difficult to realize the purpose stopped blooding in time.
In the market, also there is the product that medicament is sprayed on to injury with spray pattern, the purpose of this spray pattern is uniformly to spray Dusting powder mode is not a kind of Hemostasis.Such as: Yunnan Baiyao aerosol is mainly used for spraining, for rubbing wound and knife wound with the hands Deng it is still necessary to being stopped blooding using pulvis, it is also necessary to use the mode of hemostasis by compression (according to aerosol operation instructions).
Chinese utility model patent ZL201420372934.3 discloses a kind of hemostasis device and its component for wound, Including the container for holding hemostat, for controlling the valve of external pressure source and reservoir or disconnection, one end bending shape At the effect conduit of bending part, three-way piece is connected to container, valve and effect conduit respectively.The device can be to bleeding target tissue Quick-acting haemostatic powder is carried out, but due to the moment in Open valve, there are moment pressure releases --- make the Fluid pressure moment liter projected Height, so that therapeutic agent generates the styptic powder of moment impact, the effect generated to tissue impact force to tissue driven by pressure Position reaction force can not continue to observe so that styptic powder has been covered with the visual field, while operating laparoscope is also led by styptic powder adherency Cause can not be observed, and influence hemostat and observed in time tissue haemostatic effect, also affect the duration of endoscope-assistant surgery operation.
Utility model content
One of the utility model is designed to provide a kind of device for conveying medicament, by pressure source driving that medicament is defeated It send to target tissue, so that medicament plays therapeutic effect in target tissue.
Another of the utility model is designed to provide a kind of device for conveying medicament, imposes surely to the medicament in device Constant-pressure avoids causing to impact and generate damage to target tissue.
The further object of the utility model is to provide a kind of device for conveying medicament, will be stopped blooding by pressure source driving Agent is precisely delivered to bleeding tissue, avoids repeatedly stopping blooding to bleeding tissue, is conducive to appropriate hemostat in bleeding tissue and plays hemostasis Effect.
Another of the utility model is designed to provide a kind of device for conveying medicament, avoids the medicine for being delivered to target tissue Agent generates impact and reaction force to the position and tissue, causes the atomization of area of visual field, styptic powder is made to be adhered to equipment surfaces (such as: laparoscope mirror surface), and influence observation.
Another of the utility model is designed to provide a kind of device for conveying medicament, and the components such as conduit are fixed on device Part, or be integrally formed and manufacture with device, avoid the agent on tissue for being delivered to target tissue from generating impact, and hysteroscope observation is influenced, In favor of the progress of endoscope-assistant surgery.
A kind of device, for conveying medicament, including
Container, for accommodating medicament;
Cavity comprising cavity, chamber inlet and cavity outlet, cavity outlet is towards the bottom of container;
Valve comprising first through hole and valve body, first through hole are connected to chamber inlet and cavity outlet respectively, and valve body is by chamber Road is divided into pressure release cavity and compression cavity.
Another device, including
Container, for accommodating medicament;
Interface, for connecting pressure source;
Cavity comprising cavity, chamber inlet and cavity outlet, chamber inlet and orifice, cavity outlet direction are held The bottom of device;
Valve comprising first through hole and valve body, first through hole are connected to chamber inlet and cavity outlet respectively, and valve body is by chamber Road is divided into pressure release cavity and compression cavity.
Device provided by the utility model further includes lid, is assembled with first through hole, and first through hole is closed.
Device provided by the utility model, valve body make the fluid moved in cavity that 1 90 ° of directions change occur.
Device provided by the utility model, pressure source provide the fluid of desired pressure, such as: gas or liquid, preferential to select Gas is selected, such as: but it is not limited to air, N2、O2、CO2Or inert gas etc..
Another device further includes medicament, is placed in container, in powdered.The partial size of 90% or more powder particle≤ 100 μm, such as: partial size≤50 μm of 90% or more powder particle.
Medicament is discharged by the material effect gone out from cavity outlet from the outlet of container.
Device provided by the utility model, the cavity volume of container are 10cm3~250cm3.For convenient for operation (such as: hand-held) Preferential selection 10cm3~70cm3, especially 10cm3~30cm3, such as: but it is not limited only to 10cm3、11cm3、12cm3、13cm3、 14cm3、15cm3、16cm3、17cm3、18cm3、19cm3、20cm3、21cm3、22cm3、23cm3、24cm3、25cm3、26cm3、 27cm3、28cm3、29cm3And 30cm3
To directly act on target tissue convenient for medicament, conduit also is set in the exit of container, constitutes the utility model and mentions The device of the conveying medicament of confession.The transport path of medicament is guided by installing conduit, is also conducive to medicament close to target Target tissue is acted in the case where tissue.
In order to be conducive to the progress of endoscope-assistant surgery, the agent on tissue for being delivered to target tissue is avoided to generate the anti-work of impact With, and medicament is made to be covered with the entire hysteroscope visual field, and hysteroscope observation is influenced, the device of the utility model further includes a kind of voltage regulation part, Including pressure regulating cavity, one end opening is connected with conduit, and the cavity wall of other end opening and the axial angle of pressure regulating cavity are 3 ° ~10 °.
Medicament goes out from another end opening, and directly acts on target tissue.
In order to which further improvement result is in the pressure of target tissue, another voltage regulation part, including
Pressure regulating cavity, pressure regulation entrance are connected with conduit, and the cavity wall of pressure regulation outlet and the axial angle of pressure regulating cavity are 10 ° ~12.5 °;
It is emitted chamber, goes out entry portal and pressure regulation outlet is assembled, out the axial angle of the cavity wall of exit wound of bullet and outgoing chamber It is 5 °~6 °.
Along the radial direction of pressure regulating cavity, several groove bodies are set in the cavity wall of pressure regulating cavity.
The bore that the bore of entry portal and pressure regulation export out is identical.Between entry portal out and out exit wound of bullet, also set up slow Chamber is rushed, axial length is 0.5mm~2mm, especially 0.5mm~1.5mm.
Medicament goes out from another end opening, and directly acts on target tissue.
Device provided by the utility model, container, conduit and voltage regulation part are assembled mutually, for the defeated of medicament It send.Or by way of 3D printing or mold, container, conduit and voltage regulation part are integrally formed and manufactured, for the defeated of medicament It send.These devices are disposable medical treatment consumptive materials, convenient for manufacture and use.
Beneficial effect brought by the utility model is:
Device provided by the utility model can be real with more stable and lasting balanced propulsion mode after being connected with pressure source Now the medicament implementation in container is more lenitively conveyed, medicament is effectively avoided to be covered with the hysteroscope visual field by the reaction of target tissue, Or it is adhered to cavity mirror face, leading to not the timely operative condition for observing medicament to target tissue, (especially hemostat is to target tissue Hemostasis understanding), improve the continuity of endoscope-assistant surgery.
Device provided by the utility model, with voltage regulation part to cooperation, so that the medicament driven by pressure source more concentrates work For target tissue.It is more accurate to hemostasis administration area control especially to bleeding tissue, 75% or more medicament can be limited in In the area of radius 0.5cm~1.5cm.
Device provided by the utility model, so that the medicament driven by pressure source is more concentrated and acts on target tissue, especially To bleeding tissue, so that more pharmacy effects and the bleeding surface of a wound, can be realized hemostasis by the effect of medicament in 20 seconds, it is significant to contract Short bleeding stopping period.
It is provided by the utility model compared with the technical solution disclosed in the Chinese utility model patent ZL201420372934.3 Device conveys styptic powder to bleeding tissue, avoids hemostat powder and is caused hysteroscope area of visual field to be atomized by reaction, does not also glue It invests on the mirror surface of hysteroscope, in favor of the progress of endoscope-assistant surgery operation, bleeding tissue can be implemented more intuitive and accurately stop blooding Measure shortens operating time.
Detailed description of the invention
Fig. 1 is the structural schematic diagram for one embodiment of device that the utility model conveys medicament;
Fig. 2 is the diagrammatic cross-section of one angle of Fig. 1 shown device;
Fig. 3 is the diagrammatic cross-section for one embodiment of conduit that voltage regulation part is assembled in one end;
Fig. 4 is the diagrammatic cross-section of one embodiment of voltage regulation part;
Fig. 5 is that medicament is conveyed using existing apparatus in the schematic diagram of one embodiment of the zone of action that target tissue is formed;
Fig. 6 is that the component of the utility model conveys medicament in the schematic diagram of one embodiment of the zone of action that target tissue is formed.
Specific embodiment
The technical solution of the utility model is described in detail below in conjunction with attached drawing.The utility model embodiment is only to illustrate this The technical solution of utility model rather than limit, although the utility model is described in detail referring to preferred embodiment, ability Domain it is to be appreciated by one skilled in the art that can with the technical solution of the present invention is modified or equivalently replaced, without It is detached from the spirit and scope of the technical scheme of the present invention, should all be covered in the scope of the claims of the utility model.
Fig. 1 is the device that the utility model conveys medicament, and Fig. 2 is the diagrammatic cross-section of one angle of Fig. 1 shown device.Fig. 1 With shown in Fig. 2, the device of the present embodiment includes container 100 and cavity 200, volume of a container 15cm3.Interface 300 is set to On container 100, for connecting pressure source.In the present embodiment, pressure source provides the fluid of desired pressure, such as: gas or liquid, Preferential selection gas, such as: but it is not limited to air, N2、O2、CO2Or inert gas etc..Interface 300 is also connected to cavity 200, will be had There is the fluid of pressure to import in cavity 200.
Cavity 200 is connected to the inner cavity of container 100, including cavity 230, chamber inlet 210 and cavity outlet 220, cavity Entrance 210 is connected to interface 300, and cavity outlet 220 is towards the bottom of container.Fluid with pressure is from chamber inlet 210 Cavity 230 is imported, is flowed in cavity 230, and after the outflow of cavity outlet 220, acts on the medicament in container.Medicament by The pressure of fluid is acted on and is conveyed towards container exit.
After the valve of cracking pressure source, the fluid from pressure source, which enters after cavity 200, to flow from cavity outlet 220 rapidly Out, the medicament in cavity outlet 220 generate unexpected effect power drive medicament quickly to move to container outlet 110, When the pharmacy effect with larger momentum is after target tissue, by the reaction of target tissue, and the area that medicament is acted on is expanded (referring to Fig. 5) has dispersed medicament, reduces medicament in the concentration degree of target tissue.For in endoscope-assistant surgery in use, by target tissue Reaction, medicament is covered with whole visual field, can not continue to perform the operation, and performs the operation again after needing to take out hysteroscope wiping, affects hand The continuity of art is unfavorable for the progress of operation.
In order to avoid this situation, the device of the present embodiment further includes valve 400 comprising 410 He of first through hole Valve body 420, first through hole 410 are connected to chamber inlet 210 and cavity outlet 220 respectively, and cavity 230 is divided by valve body 420 Pressure release cavity 231 and compression cavity 232.
After the valve of cracking pressure source, the fluid from pressure source is after chamber inlet 210 enters cavity 200 through pressure-releasing chamber It behind road 231, is discharged by first through hole 410, after the fluid flow of pressure source is stablized, using lid 500 by 410 envelope of first through hole It closes, so that being discharged by cavity outlet 220 after entering compression cavity 232 from the fluid of pressure source, and acting on and be placed in container bottom Medicament.At this point, the fluid from pressure source can be acted on more stable flow and medicament, so that medicament stress is more evenly, when Pharmacy effect reduces the reaction by target tissue after target tissue, so that medicament on target tissue in more concentrating.
For endoscope-assistant surgery, the device of the present embodiment reduces pharmacy effect in the reaction of target tissue, medicament no longer shadow The visual field of hysteroscope is rung, is carried out continuously so that operation is realized.The such as square of closing first through hole 410 can be selected according to application scenarios Formula.Such as: during surgery, operator carries out first through hole 410 using thumb to press the envelope that can be achieved with to first through hole 410 It closes, so that the fluid from pressure source be imported in compression cavity 232, and is discharged by cavity outlet 220, so that the operation of device It is more convenient.For another example: for product packaging, using lid (not shown) closing first through hole 410 to keep Product transport and storage Germ-free condition.
It, can also be by devices such as flowmeters to the fluid of access in order to effectively control the flow of the fluid from pressure source It is adjusted, is pre-adjusted with pressure of the means of preset flow to fluid.
It is verified, change the flow direction of the fluid from pressure source, also can preferably solve at the beginning of fluid enters cavity 230 Stage phase and so that the medicament in conveying is generated the high momentum of moment so that medicament is by from having pressure fluid more stable and more Lasting active force.Reversing piece 421 is arranged in valve body 420, makes to be placed in the stream moved in compression cavity for the device of the present embodiment Change on 1 90 ° of direction is occurring for body.
The medicament of target tissue is acted on, is in powdered, partial size≤100 μm of 90% or more powder particle, such as: 90% or more Partial size≤50 μm of powder particle.Fluid goes out to push medicament from cavity outlet 220 and moves to 110 direction of the outlet of container, So that pharmacy effect is in target tissue.
To directly act on target tissue convenient for medicament, conduit also is set in the exit of container, the device with the present embodiment It is combined.Medicament is guided from the transport path of container outlet by installing conduit, is also conducive to medicament close to target group Target tissue is acted in the case where knitting.
In order to be conducive to the progress of endoscope-assistant surgery, the agent on tissue for further avoiding being delivered to target tissue generates impact Reaction, and medicament is made to be covered with the entire hysteroscope visual field, hysteroscope observation is influenced, the present embodiment also provides a kind of voltage regulation part and this reality The device and conduit for applying example are combined use.
Fig. 3 is the diagrammatic cross-section for one embodiment of conduit that voltage regulation part is assembled in one end, and Fig. 4 is one embodiment of voltage regulation part Diagrammatic cross-section.In conjunction with Fig. 3, as shown in figure 4, the voltage regulation part 700 of the present embodiment includes pressure regulating cavity 710, pressure regulation entrance 712 are connected with conduit 600, and the cavity wall 714 of pressure regulation outlet 713 and the axial angle b of pressure regulating cavity are 10 °~12.5 °.Along pressure regulating cavity Several groove bodies 715 are arranged in 710 radial direction in the cavity wall of pressure regulating cavity.
Also in the front of pressure regulating cavity 710 setting outgoing chamber 720, go out 713 assembly of entry portal 721 and pressure regulation outlet, outgoing The cavity wall of outlet 722 and the axial angle c of outgoing chamber are 5 °~6 °.The medicament guided through conduit goes out from the opening of angle c, And target tissue is directly acted on, the acting surface that medicament is formed on the target tissue is referring to Fig. 6.
In the present embodiment, the bore of entry portal 721 is identical with the bore of pressure regulation outlet 713 out.In entry portal out and outgoing Between outlet, cushion chamber 730 is also set up, axial length d is 0.5mm~2mm, especially 0.5mm~1.5mm.
Hemostatic agent (referring to ZL2015100443818) is loaded into the device of the present embodiment, bleeding tissue is carried out Hemostasis trial.Interface 300 is connected with gas source, is passed through the gas with pressure.Conduit 600 is aligned to the target tissue of bleeding, is pressed First through hole 410 is pressed, so that the gas with pressure enters compression cavity 232, through the change on 1 90 ° of direction, is gone out to cavity Mouth is mobile, and meets at cavity outlet with medicament.Under the promotion of gas, the medicament of 100 bottom of container by conduit outlet Discharge, acts on the bleeding surface of a wound.Gas flow is adjusted, hemostasis is observed.
It is active to bleeding after rats'liver middle period notch.During model group is through hemostatic gauze pressing haemostatic, bleeding is still Very serious, only an example is stopped blooding outer completely, remaining is incomplete hemostasis, and amount of bleeding is relatively more, and the bleeding time is longer.Use this After bleeding target tissue is administered in the device of embodiment, liver amount of bleeding is remarkably decreased, with model group there were significant differences (p < 0.001);This group of liver bleeding time compared with model group, significantly reduces (p < 0.01).It the results are shown in Table 1.
Table 1
Note: compared with model group, " * " indicates that p < 0.05, " * * * " indicate p < 0.001
Bleeding is active after rat femoral notch.It after model group gauze is sucked blood and pressed, still bleeds profusely, wherein 3 are Hemostasis failure, remaining is incomplete hemostasis, this group of bleeding time is longer.After the device administration of the present embodiment, operation Position amount of bleeding declines (p < 0.05), and the bleeding time significantly reduces, compared with the control group with the statistical difference of highly significant (p < 0.001), this group of most animals are not exclusively hemostasis, the results are shown in Table 2.
Table 2

Claims (14)

1. a kind of device, it is characterised in that including voltage regulation part, the voltage regulation part includes pressure regulating cavity, and one end opening is used It is connected in conduit, the cavity wall of other end opening and the axial angle of pressure regulating cavity are 3 °~10 °.
2. the apparatus according to claim 1, it is characterised in that along the radial direction of the pressure regulating cavity, in the chamber of the pressure regulating cavity Several groove bodies are set on wall.
3. the apparatus according to claim 1, it is characterised in that further include
Container, for accommodating medicament;
Cavity is set in container, including cavity, chamber inlet and cavity outlet, and the cavity outlet is towards the appearance The bottom of device;
Valve comprising first through hole and valve body, the first through hole respectively with the chamber inlet and the cavity Outlet, the valve body are placed in cavity, and the cavity is divided into pressure release cavity and compression cavity.
4. device according to claim 3, it is characterised in that further include interface, be set on the container, be used for Connect pressure source, the chamber inlet and the orifice.
5. device according to claim 3, it is characterised in that the valve body further includes guide part, makes the pressure-releasing chamber Road and the compression cavity extend and towards the first through hole.
6. device according to claim 3, it is characterised in that the valve body, which makes to be placed in the compression cavity, to be moved Fluid 1 90 ° of direction occur change.
7. device according to claim 3, it is characterised in that the fluid with pressure is flowed in the cavity, described Fluid be gas or liquid.
8. device according to claim 3, it is characterised in that the medicament in powdered, 90% or more powder particle Partial size≤100 μm.
9. device according to claim 3, it is characterised in that the medicament in powdered, 90% or more powder particle Partial size≤50 μm.
10. device according to claim 3, it is characterised in that the medicament is hemostat.
11. device according to claim 3, it is characterised in that the cavity volume of the container is 10cm3~250cm3
12. device according to claim 3, it is characterised in that the cavity volume of the container is 10cm3~70cm3
13. device according to claim 3, it is characterised in that the cavity volume of the container is 10cm3~30cm3
14. device according to claim 3, it is characterised in that the cavity volume of the container is 10cm3、11cm3、 12cm3、13cm3、14cm3、15cm3、16cm3、17cm3、18cm3、19cm3、20cm3、21cm3、22cm3、23cm3、24cm3、 25cm3、26cm3、27cm3、28cm3、29cm3Or 30cm3
CN201821858909.0U 2018-08-01 2018-08-01 Convey the device of medicament Active CN209421888U (en)

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CN201821858909.0U CN209421888U (en) 2018-08-01 2018-08-01 Convey the device of medicament
CN201821234008.4U CN209421996U (en) 2018-08-01 2018-08-01 Convey the device of medicament

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CN201821858548.XU Active CN209421887U (en) 2018-08-01 2018-08-01 Convey the device of medicament
CN201821234008.4U Active CN209421996U (en) 2018-08-01 2018-08-01 Convey the device of medicament

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CN209421887U (en) 2019-09-24

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