CN209332099U - Intravascular ultrasound catheter - Google Patents
Intravascular ultrasound catheter Download PDFInfo
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- CN209332099U CN209332099U CN201822220773.7U CN201822220773U CN209332099U CN 209332099 U CN209332099 U CN 209332099U CN 201822220773 U CN201822220773 U CN 201822220773U CN 209332099 U CN209332099 U CN 209332099U
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- sheath
- transmission shaft
- buffer layer
- ultrasound catheter
- intravascular ultrasound
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Abstract
Present disclose provides a kind of intravascular ultrasound catheters characterized by comprising sheath, the outer layer with buffer layer and the covering buffer layer, the sheath has guiding inner cavity, and the sheath has pliability;And transmission shaft, it with ultrasonic transducer, and can be moved along the guiding inner cavity of the sheath, the buffer layer contacts of the transmission shaft and the sheath, wherein the transmission shaft forms sliding friction with the sheath via buffer layer.In the disclosure, sheath has guiding inner cavity, transmission shaft can be moved along the guiding inner cavity of sheath, and transmission shaft forms sliding friction via buffer layer and with sheath, in this case, transmission shaft can reduce the frictional force with sheath when carrying out high speed rotation and withdrawing, so as to ensure and be driven the ultrasound image that the ultrasonic transducer of axis connection can be collected into high quality during withdrawing.
Description
Technical field
This disclosure relates to insertion type field of medical technology more particularly to a kind of intravascular ultrasound catheter.
Background technique
Intravascular ultrasound system (Intravascular Ultrasound, IVUS), which refers to, utilizes ultrasonic technique and insertion type
The system that microcatheter technology carries out ultrasonic imaging in the blood vessels.This technology mainly passes through insertion type conduit for the ultrasound of micromation
Energy converter is placed in endovascular specific position, and when ultrasonic transducer is withdrawn, ultrasonic transducer generates ultrasonic signal, ultrasonic signal
It propagates and is reflected in tissue, and convert electric signal for received reflection signal, then, the figure of IVUS host system
As processing unit is handled and shown to electric signal, to obtain the image information of vessel lumen and tube wall.
Common mechanical IVUS system ultrasound catheter generally has two parts of sheath and transmission shaft, sheath on Vehicles Collected from Market
The inside of pipe allows the movement of the transmission shaft with ultrasonic transducer.In IVUS imaging process, transmission shaft high speed rotation and return
It removes, external sheath remains stationary, and the super of target position (such as stenosis of blood vessel) is obtained by rotary ultrasonic energy converter
Acoustic imaging information.In existing ultrasound catheter, although working as distal sheath there are certain gap between transmission shaft and sheath
Pipe enter tortuous coronary artery blood vessel when, the frictional force between transmission shaft and sheath can increase, it is easy to cause ultrasonic transducer at
As there is non-uniform rotation pseudomorphism, the judgement of medical staff is influenced.
Summary of the invention
The utility model can improve transmission shaft its purpose is to provide one kind and be imaged in view of above-mentioned current condition
The intravascular ultrasound catheter of image quality in the process.
In order to solve the above technical problems existing in the prior art, the utility model provides a kind of intravascular ultrasound and leads
Pipe characterized by comprising sheath, the outer layer with buffer layer and the covering buffer layer, the sheath have in guiding
Chamber, and the sheath has pliability;And transmission shaft, with ultrasonic transducer, and can leading along the sheath
It is mobile to draw inner cavity, the transmission shaft has pliability, wherein the transmission shaft is formed with the sheath and slided via buffer layer
Friction.
In the present invention, in the blood vessels in ultrasound catheter, sheath has guiding inner cavity, and transmission shaft can be along sheath
It is mobile to guide inner cavity, and transmission shaft forms sliding friction via buffer layer and with sheath, in this case, transmission shaft can
Reduce the frictional force with sheath, when carrying out high speed rotation and withdrawing so as to ensure and be driven the ultrasonic transducer of axis connection
The ultrasound image of high quality can be collected into during withdrawing.
In the intravascular ultrasound catheter involved in the utility model, optionally, the buffer layer is by being selected from polytetrafluoroethyl-ne
The formation of at least one of alkene, molybdenum disulfide, polyvinyl chloride and polyester elastomer.Thereby, it is possible to further improve buffer layer with
Sliding friction between transmission shaft.
In the intravascular ultrasound catheter involved in the utility model, optionally, the sheath have proximal part and with
The outer diameter of the distal portions that the proximal part connects, the sheath gradually subtracts from the proximal part to the distal portions
It is small.The resistance advanced in the blood vessels thereby, it is possible to reduce intravascular ultrasound catheter.
In the intravascular ultrasound catheter involved in the utility model, optionally, the Young's modulus of the outer layer is greater than institute
State the Young's modulus of buffer layer.Thereby, it is possible to take into account the internal layer pliability of sheath and the hardness of outer layer.
In the intravascular ultrasound catheter involved in the utility model, optionally, the transmission shaft have spring structure and
Coating coated in the spring structure.In this case, it not only can guarantee that transmission shaft had good pliability, but also can change
Contact friction between kind transmission shaft and sheath.
In the intravascular ultrasound catheter involved in the utility model, optionally, the spring structure is by selected from metal, conjunction
The formation of at least one of gold, carbon, rubber and resin.Thereby, it is possible to promote the anti-twist ability of spring.
In the intravascular ultrasound catheter involved in the utility model, optionally, on the surface of the outer layer, it is coated with light
Sliding coating.The resistance advanced in the blood vessels thereby, it is possible to improve intravascular ultrasound catheter.
In the intravascular ultrasound catheter involved in the utility model, optionally, the coating is by being selected from polyvinyl pyrrole
The formation of at least one of alkanone, polyoxyethylene, polyphenylene oxide and maleic acid.Thereby, it is possible to improve the bio-compatibility of coating.
In the intravascular ultrasound catheter involved in the utility model, optionally, the buffer layer and the outer layer are used
The mode of sweat soldering engages, and the sweat soldering is at least resistance heating welding, infrared heating welding, laser sweat soldering
At least one of with ultrasonic bonding.Thereby, it is possible to be welded on buffer layer well on the outer layer of sheath.
In the intravascular ultrasound catheter involved in the utility model, optionally, the thickness of the outer layer is greater than described slow
Rush the thickness of layer.Thereby, it is possible to further enhance the supporting role of outer layer.
According to the disclosure, a kind of intravascular ultrasound that can improve image quality of the transmission shaft in imaging process is provided
Conduit.
Detailed description of the invention
Fig. 1 is to show the schematic diagram of the intravascular ultrasound system involved in the disclosure including intravascular ultrasound catheter.
Fig. 2 is to show the schematic internal view of intravascular ultrasound catheter involved in the disclosure.
Fig. 3 is the exemplary schematic diagram of shape for the sheath for showing intravascular ultrasound catheter involved in the disclosure.
Fig. 4 is the sheath for showing intravascular ultrasound catheter involved in the disclosure and the schematic diagram of coating.
Fig. 5 is to show the signal in the section of the line A-A ' along Fig. 4 of intravascular ultrasound catheter involved in the disclosure
Figure.
Specific embodiment
Hereinafter, explaining the preferred embodiment of the disclosure in detail with reference to attached drawing.In the following description, for identical
Component assign identical symbol, the repetitive description thereof will be omitted.Scheme in addition, attached drawing is only schematical, the mutual ruler of component
Very little shape of ratio or component etc. can be with actual difference.
Fig. 1 is to show the schematic diagram of the intravascular ultrasound system involved in the disclosure including intravascular ultrasound catheter.
As shown in Figure 1, intravascular ultrasound system (IVUS) may include that intravascular ultrasound catheter is (sometimes referred to as " super below
Acoustic conducting pipe ") 1, connect with ultrasound catheter 1 and control ultrasound catheter 1 withdraw withdraw system 2 and will be obtained by ultrasound catheter 1
The host system 3 that the image-forming information taken is handled.
In some instances, in the blood vessels ultrasonic system work when, ultrasound catheter 1 can be placed in it is intracorporal intravascular, and
Withdraw system 2 and host system 3 in vitro, withdrawing system 2 can control the movement in the blood vessels of ultrasound catheter 1 and to blood vessel
Interior specific position (such as stenosis of blood vessel) carries out ultrasonic imaging, and ultrasound catheter 1 can transmit the image-forming information of acquisition
To host system 3, host system 3 can carry out processing to the image-forming information to show example on host system (such as screen)
Such as the image of endovascular inner cavity and inner wall.
In some instances, ultrasound catheter 1 can be removably mounted in the system of withdrawing 2.In this case, ultrasonic
Conduit 1 can according to need to be installed or removed in the system that withdraws 2.In addition, in the present embodiment, withdrawing system 2 can be used
The ultrasound catheter 1 of different sizes and type.
Fig. 2 is to show the schematic internal view of intravascular ultrasound catheter involved in the disclosure.Fig. 3 is to show the disclosure
The exemplary schematic diagram of the shape of the sheath of related intravascular ultrasound catheter.
In some instances, ultrasound catheter 1 may include sheath 11 and transmission shaft 12 (referring to fig. 2).Sheath 11, which has, to be led
Draw inner cavity 110, transmission shaft 12 can be slided along the guiding inner cavity 110 of sheath 11.Since transmission shaft 12 has ultrasonic transducer
(not shown), so that the ultrasonic transducer of transmission shaft 12 can be to blood when transmission shaft 12 is slided along guiding inner cavity 110
Ultrasonic imaging is carried out in pipe.Specifically, issuing ultrasonic signal to blood vessel from ultrasonic transducer is for example radial, ultrasonic signal is in example
It is propagated Ru intravascular, and ultrasonic transducer can receive the echo-signal through Tissue reflectance, and echo-signal is converted
For the electric signal comprising ultrasonic imaging information.
In above-mentioned ultrasound imaging procedure, ultrasonic transducer for example travels to blood vessel by the opening of transmission shaft (not shown)
Wall, and sheath 11 generally uses the material insensitive to ultrasound, therefore, for example, by withdrawing ultrasonic transducer in rotation, energy
It is enough that ultrasonic imaging is carried out to lumen of vessels and surrounding.
In the present embodiment, sheath 11 may include proximal part 11a and distal portions 11b (referring to Fig. 3).In this reality
It applies in mode, it is however generally that, distal portions 11b is relative to proximal part 11a closer to proximal part 11a and distal portions 11b
It is connected.
In some instances, the outer diameter of sheath 11 can proximally part 11a be gradually reduced to the direction distal portions 11b.
In this case, can reduce the resistance that sheath 11 is advanced in the blood vessels can reduce.In addition, in some instances, sheath 11
Distal portions 11b outer diameter can be formed by the methods of thermoplastic, blow molding, hot melt, compression proximally part 11a to distal portion
The shape for dividing the direction 11b to be gradually reduced.
In addition, although described above is the outer diameter of sheath 11 can proximally part 11a to the direction distal portions 11b gradually
Reduce, but present embodiment is without being limited thereto, in some instances, the outer diameter of sheath 11 can also proximally part 11a to remote
The direction end part 11b remains unchanged.
In addition, in the sheath 11 involved in present embodiment, proximal part 11a and distal portions 11b can respectively by
Different materials are constituted.In addition, in some instances, proximal part 11a and distal portions 11b can pass through integrated molding shape
At.
In addition, in some instances, the end of the distal portions 11b of sheath 11 can be circular shape (referring to Fig. 3).By
This, can improve the contact of sheath 11 with patient's body anatomical structure (such as intravascular), alleviate damage of the sheath 11 to blood vessel.
In addition, in some instances, sheath 11 can have pliability, thus, it is possible to further alleviate sheath 11 in movement
It is damaged caused by blood vessel in the process.In some instances, the distal portions 111 of sheath 11 can have the proximal end than sheath 11
The higher pliability in part 112.
As described above, sheath 11 has the guiding inner cavity 110 of internal run-through.In this case, ultrasonic transducer is had
Transmission shaft 12 (such as sliding) can be moved along the guiding inner cavity 110 of sheath 11.For example using ultrasound catheter 1 to human body
When carrying out intervention operation progress ultrasonic imaging, sheath 11 (such as distal portions 11b of sheath 11) is placed into the dissection of patient
The appropriate location (such as stenosis of blood vessel) of structure, in this case, the ultrasonic transducer of transmission shaft 12 can be along leading
Tube cavity 110 is withdrawn, for example, by withdrawing ultrasonic transducer while rotating, so as to the stenosis to such as blood vessel
Carry out ultrasonic imaging.
Fig. 4 is to show the exemplary schematic diagram of conduit shape of intravascular ultrasound catheter involved in the disclosure.Fig. 5 is to show
The schematic diagram in the section of the line A-A ' along Fig. 4 of intravascular ultrasound catheter involved in the disclosure is gone out.
In some instances, sheath 11 may include the outer layer 112 of buffer layer 111 and covering buffer layer 111.In sheath 11
In, the setting of buffer layer 111 is in inside, therefore transmission shaft 12 is contacted in guiding inner cavity 110 with buffer layer 111, that is, working as transmission shaft
12 when guiding the movement of inner cavity 110, and transmission shaft 12 can be in contact with buffer layer 111.In some instances, in order to reduce due to
Friction between the guiding inner cavity 110 of sheath 11 and transmission shaft 12, transmission shaft 12 are (specific with sheath 11 via buffer layer 111
It is guiding inner cavity 110) form sliding friction.
In some instances, the thickness of outer layer 112 can be greater than the thickness of buffer layer 111.Thereby, it is possible to further enhance
Supporting role of the outer layer 112 for buffer layer 111.
In some instances, the buffer layer 111 of sheath 11 can be made of the material with good lubricating properties.As a result, can
Enough frictions improved when transmission shaft 12 is withdrawn between transmission shaft 12 and the buffer layer of sheath 11 111.In some instances, it buffers
Layer 111 can be by being formed selected from least one of polytetrafluoroethylene (PTFE), molybdenum disulfide, polyvinyl chloride and polyester elastomer.
In some instances, outer layer 112 is arranged on buffer layer 111 and surrounds buffer layer 111.As described above, outer layer 112
Buffer layer 111 can be covered, outer layer can provide support for buffer layer 111.In other words, in ultrasound catheter 1, sheath 11 is delayed
Layer 111 is rushed to be located between the outer layer 112 and transmission shaft 12 of sheath 11.
In some instances, outer layer 112 can by ABS resin (acrylonitrile-butadiene-styrene copolymer), silicon rubber,
The formation of at least one of polyphenylene sulfide, n-butanol, butadiene-styrene rubber, molybdenum trioxide, nano-graphene and epoxide-resin glue.
In some instances, the Young's modulus of outer layer 112 can be greater than the Young's modulus of buffer layer 111.For example, outer layer
112 can be formed by the relatively large silicon rubber of Young's modulus, and buffer layer 111 can be by the relatively small polychlorostyrene second of Young's modulus
Alkene is formed.In this case, the rigidity of outer layer 112 can be greater than the rigidity of buffer layer 111, and thus, it is possible to more preferably take into account outer layer
112 rigidity can also mitigate the friction between buffer layer 111 and such as transmission shaft 12.
In some instances, buffer layer 111 can be combined with outer layer 112 by way of sweat soldering.In some examples
In, sweat soldering can in resistance heating welding, infrared heating welding, laser sweat soldering and ultrasonic bonding at least
It is a kind of.In this case, buffer layer 111 can be fixedly combined with outer layer 112.In addition, in other examples, buffer layer
111 can also be connect with outer layer 112 using modes such as glued, adherency.
In some instances, on the surface of outer layer 112, coating (not shown) can be coated with.By coating bio-compatible
The coating 114 of property, can be improved sheath 11 and for example endovascular bio-compatibility.In addition, in some instances, coating 114
Can have good lubricity and hydrophily, can further decrease sheath 11 and it is for example intravascular between friction, reduce
The resistance and inhibit damage of the sheath 11 to blood vessel that sheath 11 is advanced in the blood vessels.
In some instances, coating 114 can be by being selected from polyvinylpyrrolidone, polyoxyethylene, polyphenylene oxide and Malaysia
The formation of at least one of acid.In some instances, coating 114 can pass through the modes such as adherency, hot melt, gluing and outer layer 112
In conjunction with.
In some instances, sheath 11 can have the through-hole (not shown) for allowing blood flow to pass through.In this case, energy
It moves sheath 11 preferably in the blood vessels, reduces influence of the sheath 11 to intravascular blood flow state.
In some instances, ultrasound catheter 1 may include transmission shaft 12.Transmission shaft 12 can be connect with ultrasonic transducer,
Withdrawing system 2 withdraws ultrasonic transducer by controlling transmission shaft 12, and ultrasonic transducer needs high speed rotation when withdrawing, and passes
Twisting resistance of the moving axis 12 to bear to withdraw system application.
In some instances, the interface that transmission shaft 12 can be connect with the system that withdraws 2.In some instances, proximal part
The interface of 11a can use mechanical structure.For example, mechanical structure interface can be buckle-type, bolt connection type, socket joint connection
Formula, plow groove interconnection system etc..
In some instances, transmission shaft 12 has pliability.In this case, transmission shaft 12 can be adapted to sheath 11
In curved intravascular traveling, avoid that blood vessel is caused to damage.
In addition, in some instances, transmission shaft 12 can have spring structure and the coating coated in spring structure.
In some instances, spring structure can be helical spring, valute spring, torsion-bar spring, disk spring, ring
Shape spring and flat spring at least one of are worked as.In some instances, spring structure can be formed by hollow helical spring.Separately
Outside, in some instances, spring structure can also be by forming selected from least one of alloy, carbon, rubber and resin.
In some instances, spring structure can be formed by two layers of spring of inner spray construction and outer spring structure.This
In the case of, it can be improved the reliability of spring structure, especially transmission shaft 12 and be not easy when being withdrawn system traction and being withdrawn
The case where being now broken.
In some instances, outer spring structure can be located at the outer layer of spring structure, and inner spray construction can be located at spring
The internal layer of structure, outer spring structure can be closely attached on inner spray construction.In some instances, outer spring structure can be with
It is fixed on inner spray construction by bonding agent.In some instances, the spacing of adjacent springs compares outer spring in inner spray construction
The spacing of adjacent springs is smaller in structure.
In addition, in some instances, it is adjacent in outer spring structure from the proximal part 11a to distal portions 11b of sheath 11
The spacing of spring becomes much larger.Thereby, it is possible to guarantee the flexible to improve transmission of the outer spring structure close to distal portions 11b
Movement of the axis 12 in sheath 11 can also improve the supporting role of the outer spring structure of proximal part 11a, be convenient for transmission shaft 12
Withdraw.
In some instances, the coating coated in spring structure can be film.In some instances, film can be by
The formation of at least one of polyvinylpyrrolidone, polyoxyethylene, polyphenylene oxide and maleic acid.In this case, can subtract
Few coating causes to damage to patient tissue such as blood vessel composition.
In addition, in some instances, coating can be the protective layer for enhancing spring structure.In this case,
Protective layer can be made to be less likely to occur to deform by protective layer come reinforcement spring structure.In some instances, which can be with
At least one of work as zinc, chromium, cadmium, copper, nickel, tin, silver and zinc titanium alloy.In addition, in some instances, protective layer can also be with
For the chemical coating handled by oxidation processes, phosphorating treatment or innoxious japanning.
In some instances, the contact between transmission shaft 12 and buffer layer 111 can contact for line.In this case,
The frictional force between transmission shaft 12 and buffer layer 111 can be further decreased.Certainly, in practice, transmission shaft 12 and buffer layer
Contact between 11 has certain contact area, it is not easy to form line contact, still, by make transmission shaft 12 and buffer layer 11 it
Between formed line contact.
In some instances, the transmission shaft 12 of ultrasound catheter 1 may include that the signal wire connecting with ultrasonic transducer (is not schemed
Show).In some instances, signal wire can pass to ultrasonic transducer electric signal obtained at external device such as host
Reason system.In some instances, signal wire can be placed in the hollow position of the spring structure in transmission shaft 12, pass through spring structure
Metallic shield, can improve signal transmission.
In some instances, when the transmission shaft 12 in ultrasound catheter 1 is advanced in sheath 11, transmission shaft 12 can be with sheath
Buffer layer 111 in 11 forms sliding friction.Frictional force between transmission shaft 12 and buffer layer 111 is smaller, and transmission shaft 12 more holds
It is easily carried out in sheath 11, so that being more advantageous to ultrasonic transducer forms homogeneous image.
In some instances, this disclosure relates to ultrasound catheter 1 be not limited to using in ultrasound catheter in the blood vessels,
It can be used in the insertion type therapeutic device that other are withdrawn or are promoted.In general, insertion type medical instrument
Refer to and be inserted into human body or natural accent by surgical means, carries out treating or checking for short time, treat or check and finish i.e.
It takes out.In the insertion type medical instrument of some other similar image collections, need to be promoted or withdrawn using transmission shaft,
By the conduit of the disclosure, the picture quality to collect pictures can be enhanced, while the convenience used also greatly improves.
In addition, can also be separately provided super with ultrasonic transducer in the ultrasound catheter 1 involved in present embodiment
Sonic probe, ultrasonic probe can be configured to connect with transmission shaft 12 at this time.In this case, during withdrawing, transmission shaft
Rotation recession movement can be carried out together with related ultrasonic probe.At the same time, the ultrasonic transducer that ultrasonic probe is arranged in can be with
Ultrasonic signal is generated during withdrawing, ultrasonic signal is propagated in tissue, and ultrasonic transducer can receive reflection
Echo-signal, and convert electric signal for echo-signal.
Although being illustrated in conjunction with the accompanying drawings and embodiments to the disclosure above, it will be appreciated that above description
The disclosure is not limited in any form.Those skilled in the art can without departing from the connotation and range of the disclosure
To be deformed and be changed to the disclosure as needed, these deformations and variation are each fallen in the scope of the present disclosure.
Claims (10)
1. a kind of intravascular ultrasound catheter, which is characterized in that
Include:
Sheath, the outer layer with buffer layer and the covering buffer layer, the sheath have guiding inner cavity, and the sheath
With pliability;And
Transmission shaft with ultrasonic transducer, and can be moved along the guiding inner cavity of the sheath, the transmission shaft with it is described
The buffer layer contacts of sheath,
Wherein, the transmission shaft forms sliding friction via buffer layer and with the sheath,
The buffer layer selected from one of polytetrafluoroethylene (PTFE), molybdenum disulfide, polyvinyl chloride and polyester elastomer by forming.
2. intravascular ultrasound catheter as described in claim 1, which is characterized in that
The distal portions that the sheath has proximal part and connects with the proximal part,
The outer diameter of the sheath is gradually reduced from the proximal part to the distal portions.
3. intravascular ultrasound catheter as described in claim 1, which is characterized in that
The Young's modulus of the outer layer is greater than the Young's modulus of the buffer layer.
4. intravascular ultrasound catheter as described in claim 1, which is characterized in that
The transmission shaft has spring structure and the coating coated in the spring structure.
5. intravascular ultrasound catheter as claimed in claim 4, which is characterized in that
The spring structure selected from one of metal, alloy, carbon, rubber and resin by forming.
6. intravascular ultrasound catheter as described in claim 4 or 5, which is characterized in that
The Young's modulus of the coating is less than the Young's modulus of the buffer layer.
7. intravascular ultrasound catheter as described in claim 1, which is characterized in that
On the surface of the outer layer, the coating coated with bio-compatibility.
8. intravascular ultrasound catheter as claimed in claim 7, which is characterized in that
The coating selected from one of polyvinylpyrrolidone, polyoxyethylene, polyphenylene oxide and maleic acid by forming.
9. intravascular ultrasound catheter as described in claim 1, which is characterized in that
The buffer layer is engaged by the way of sweat soldering with the outer layer.
10. intravascular ultrasound catheter as described in claim 1, which is characterized in that
The thickness of the outer layer is greater than the thickness of the buffer layer.
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CN201822220773.7U CN209332099U (en) | 2018-12-27 | 2018-12-27 | Intravascular ultrasound catheter |
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CN201822220773.7U CN209332099U (en) | 2018-12-27 | 2018-12-27 | Intravascular ultrasound catheter |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN109646053A (en) * | 2018-12-27 | 2019-04-19 | 深圳北芯生命科技有限公司 | Intravascular ultrasound catheter |
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Publication number | Priority date | Publication date | Assignee | Title |
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CN109646053A (en) * | 2018-12-27 | 2019-04-19 | 深圳北芯生命科技有限公司 | Intravascular ultrasound catheter |
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Address after: Area E, 3 / F, building 3, Tingwei Industrial Park, No.6 Liufang Road, Xin'an street, Bao'an District, Shenzhen City, Guangdong Province Patentee after: Shenzhen Beixin Life Technology Co.,Ltd. Address before: Area E, 3 / F, building 3, Tingwei Industrial Park, No.6 Liufang Road, Xin'an street, Bao'an District, Shenzhen City, Guangdong Province Patentee before: INSIGHT LIFETECH Co.,Ltd. (SHENZHEN ) |
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