CN209292326U - A kind of magnetic frame - Google Patents
A kind of magnetic frame Download PDFInfo
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- CN209292326U CN209292326U CN201821657311.5U CN201821657311U CN209292326U CN 209292326 U CN209292326 U CN 209292326U CN 201821657311 U CN201821657311 U CN 201821657311U CN 209292326 U CN209292326 U CN 209292326U
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- micropore
- panel
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- bottom plate
- magnetic
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Abstract
This application discloses a kind of magnetic frames.The magnetic frame of the application includes panel, magnetic stripe group and bottom plate；The micropore for accommodating 96 hole PCR plates, micropore quantity column more than 96 hole PCR plates are opened up on panel；Magnetic stripe group is made of seven bar magnets, is located between panel and bottom plate, parallel with micropore column；First bar magnet is installed between first row and secondary series micropore, and so on, Article 7 magnet finally is installed by panel sidewalls side in the 13rd column micropore；Bottom plate is fixed on the back of the panel by clamping or screw.The magnetic frame of the application, it is on panel to increase by a column more, so that 96 hole PCR plates or other porous plates, magnet positions can be changed by way of a mobile column, so that magnetic bead side out of pipe is moved to the other side, play the role of washing magnetic bead automatically, conveniently and simplifies Beads enrichment technique.Also, in improvement project, magnetic bead is adsorbed on the side wall of specified altitude assignment position by the height of adjustable magnet, to play the role of adjusting magnetic bead absorption position.
Description
Technical field
This application involves biomagnetism microballoon separation equipment fields, more particularly to a kind of magnetic frame.
Background technique
Magnetic frame is a kind of equipment for separating magnetic microsphere from liquid, is provided with magnet on usual magnetic frame,
And magnetic microsphere is iron or other similar magnetic metal materials.In nucleic acid separation, biomagnetic beads partition method is often used,
I.e. by nucleic acid absorption on the magnetic bead of biochemical modification, magnetic bead adsorption precipitation is then realized by nucleic acid and its using magnetic frame
The separation of its substance.
Existing magnetic frame is usually all magnet to be mounted on to fixed position, and have a single function, and is only had magnetic bead
It is absorbed and fixed at the function of tube bottom.
Summary of the invention
The purpose of the application is to provide a kind of improved new magnetic frame of structure.
The application uses following technical scheme:
This application discloses a kind of magnetic frames, including panel, magnetic stripe group and bottom plate；It is offered on panel and accommodates 96 hole PCR
The micropore of plate, the quantity of micropore column more than 96 hole PCR plates, i.e., be provided with 8 × 13 array micropores on panel；Magnetic stripe group is by seven
Bar magnet composition, magnetic stripe group is located between panel and bottom plate, along the column direction of micropore, installation parallel with micropore column；Specifically,
First bar magnet is installed between first row micropore and secondary series micropore, Article 2 is installed between third column micropore and the 4th column micropore
Magnet, and so on, Article 6 magnet is installed, finally in the 13rd column micropore between the 11st column micropore and the 12nd column micropore
Article 7 magnet is installed close to the side of panel sidewalls；Bottom plate is fastened on the back side of panel by clamping or screw, plays branch
Support effect.
It should be noted that the magnetic frame of the application when in use can be by magnetic bead for traditional magnetic frame
It is adsorbed in the side of PCR pipe, then moves a column, due to changing the position of magnet, so that magnetic bead is mobile by the side of PCR pipe
To the other side, this process, which is equivalent to, has carried out once washing to magnetic bead, can be realized do not changing object in PCR pipe repeatedly
In the case where matter, magnetic bead is sufficiently washed.That is, the magnetic frame of the application increases magnetic bead than traditional magnetic frame
Washing function.
Preferably, in magnetic stripe group, several tightening screws are provided on every corresponding bottom plate position of bar magnet, by adjusting
The height of tightening screw realizes the height adjustment of every bar magnet.
It should be noted that existing magnetic frame, the height and position etc. of magnet is all fixed and invariable, and the application
Magnetic frame, magnet are supported by tightening screw, adjust its height by rotating tightening screw, the tune of magnet height can be realized
Whole, use is more flexible.
It is appreciated that present invention design is not limited only to 96 hole PCR plates, it is readily applicable to other porous plates.Cause
This, the another side of the application discloses a kind of magnetic frame, including panel, magnetic stripe group and bottom plate；It is porous that receiving is offered on panel
The micropore of plate, the quantity of micropore column more than porous plate, the i.e. array of porous plate are n × m, then the microwell array on panel is n
× (m+1), wherein n is line number, m is columns；Magnetic stripe group is located between panel and bottom plate, along the column direction of micropore, with micropore
The parallel installation of column；Specifically, the first bar magnet is installed between first row micropore and secondary series micropore, third column micropore and the 4th column
Second bar magnet is installed between micropore, and so on, if the micropore columns position odd number on panel, close in last column micropore
The side of panel sidewalls is installed by the last item magnet；Bottom plate is fastened on the back side of panel by clamping or screw, plays support
Effect.Wherein, m is usually even number, and therefore, the magnet quantity of magnetic stripe group is usually m ÷ 2+1 item.Likewise, magnet can pass through
Tightening screw adjusts its height.
Wherein, porous plate can be 6 orifice plates, eight platoon pore plate of PCR, 12 orifice plates, 24 orifice plates, 48 orifice plates or other normal
The porous plate of rule, is not specifically limited herein.
It is appreciated that the number cells of usually every row are greater than the number cells of each column, therefore, increasing by a column is to compare saving
The mode of plate；It is of course also possible to increase a line, the change magnet positions that equally can be realized the application make magnetic bead by PCR pipe
Side be moved to the function of the other side.
Therefore, the application discloses a kind of magnetic frame, including panel, magnetic stripe group and bottom plate on one side again；It is opened up on panel
There is the micropore for accommodating porous plate, for the quantity of micropore compared with the more a line of porous plate, i.e. the array of porous plate is n × m, then micro- on panel
Hole array is (n+1) × m, wherein n is line number, m is columns；Magnetic stripe group is located between panel and bottom plate, along the row side of micropore
To parallel with every row micropore to install；Specifically, installing the first bar magnet, the third line between the first row micropore and the second row micropore
Second bar magnet is installed between micropore and fourth line micropore, and so on, if the micropore line number position odd number on panel, last
A line micropore installs the last item magnet close to the side of panel sidewalls；Bottom plate is fastened on panel by clamping or screw
The back side plays a supportive role.
It should be noted that in the case where increasing a line, the magnetic frame of the application can adsorb magnetic bead when in use
In the side of PCR pipe, a line is then moved, due to changing the position of magnet, can equally make magnetic bead by a sidesway of PCR pipe
It moves to the other side, realizes magnetic bead washing function.Likewise, magnet can adjust its height by tightening screw.Porous plate can also
To be 6 orifice plates, eight platoon pore plate of PCR, 12 orifice plates, 24 orifice plates, 48 orifice plates or other conventional porous plates.
The beneficial effects of the present application are as follows:
The magnetic frame of the application, by way of one column of increase more on panel or a line, so that 96 hole PCR plates or other
Porous plate when in use, can change magnet positions by way of a mobile column or a line, to realize magnetic bead out of pipe
Side be moved to the other side, play the role of washing magnetic bead automatically inside pipe, compared with existing magnetic frame, the application's
Magnetic frame increases magnetic bead washing function, convenient and simplify substance separation based on magnetic bead, purifying technique.
In a kind of improvement project of the application, several are provided on every corresponding bottom plate position of bar magnet and screws spiral shell
The height adjustment of every bar magnet may be implemented by adjusting the height of tightening screw, magnetic bead can be adsorbed on specified altitude assignment for nail
Or on the side wall of position.
Detailed description of the invention
Fig. 1 is the decomposition texture schematic diagram of magnetic frame in the embodiment of the present application；
Fig. 2 is the perspective structure schematic diagram of assembled magnetic frame in the embodiment of the present application；
Fig. 3 is the positive structure schematic of assembled magnetic frame in the embodiment of the present application；
Fig. 4 is the structural schematic diagram that the magnet of magnetic frame is parallel with every row micropore in the embodiment of the present application.
Specific embodiment
The application is described in further detail below by specific embodiment.Following embodiment only to the application carry out into
One step explanation, should not be construed as the limitation to the application.
Embodiment
The magnetic frame of this example, as shown in Figure 1 to Figure 3, including panel 1, magnetic stripe group 2 and bottom plate 3；Appearance is offered on panel 1
Receive the micropores of 96 hole PCR plates, the quantity of micropore column more than 96 hole PCR plates are provided with 8 × 13 array micropores on panel 1；
Magnetic stripe group 2 is made of seven bar magnets, and magnetic stripe group 2 is located between panel 1 and bottom plate 3, flat with micropore column along the column direction of micropore
Row installation；Specifically, as shown in figure 3, from right to left, the first bar magnet is installed between first row micropore and secondary series micropore,
The second bar magnet is installed between three column micropores and the 4th column micropore, and so on, the 11st column micropore and the 12nd column micropore it
Between install Article 6 magnet, finally the 13rd column micropore close to panel sidewalls side install Article 7 magnet；Bottom plate 3 passes through
Clamping or screw are fastened on the back side of panel 1, play a supportive role.In magnetic stripe group 2, every corresponding 3 position of bottom plate of bar magnet
On be provided with several tightening screws 4, by adjusting tightening screw 4 height realize every bar magnet height adjustment.
The magnetic frame of this example, in use, 96 hole PCR plates insertion panel 1 micropore in, the first tubulation of 96 hole PCR plates with
The first row micropore of panel is corresponding；At this point, the magnetic bead in the first tubulation and the second tubulation concentrates on PCR by the absorption of the first bar magnet
The side of pipe；Then, by the mobile column of 96 hole PCR plates, the first tubulation is inserted into secondary series micropore, at this point, the first tubulation is mobile
To the another side of the first bar magnet, so that the magnetic bead in the first tubulation is moved to the other side by side；At the same time, secondary series
It manages closer to the second bar magnet, therefore, the magnetic bead in the second tubulation is also to mobile close to the side of the second bar magnet；Other column
Situation is similar.Therefore, magnetic bead can be made to be moved to the other side by the side of PCR pipe by the mobile column of 96 hole PCR plates, thus real
Existing magnetic bead washing function.
It is appreciated that the magnetic frame of this example is the magnetic bead washing function for increasing column realization on panel；Likewise,
The function can be realized by way of increasing a line, in the case where increasing a line, the arrangement of magnet is exactly along the row side of micropore
To, it is parallel with every row micropore to install, as shown in figure 4, magnetic frame equally includes panel, magnetic stripe group and bottom plate；It is offered on panel
The micropore of porous plate is accommodated, the quantity of micropore is compared with the more a line of porous plate, i.e. the array of porous plate is n × m, then the micropore on panel
Array is (n+1) × m, wherein n is line number, m is columns；Magnetic stripe group is located between panel and bottom plate, along the row side of micropore
To parallel with every row micropore to install；Specifically, installing the first bar magnet, the third line between the first row micropore and the second row micropore
Second bar magnet is installed between micropore and fourth line micropore, and so on, if the micropore line number position odd number on panel, last
A line micropore installs the last item magnet close to the side of panel sidewalls；Bottom plate is fastened on panel by clamping or screw
The back side plays a supportive role.In magnetic stripe group, several tightening screws are provided on every corresponding bottom plate position of bar magnet, pass through tune
The height of whole tightening screw realizes the height adjustment of every bar magnet.Fig. 4 is the magnetic frame designed for 96 hole PCR plates, on panel
The micropore for accommodating 96 hole PCR plates is offered, the quantity of micropore is provided with 9 × 12 battle arrays compared with 96 more a line of hole PCR plate on panel
Column micropore；Magnetic stripe group is made of five bar magnets, installs the first bar magnet between the first row micropore and the second row micropore, the third line is micro-
Second bar magnet is installed between hole and fourth line micropore, and so on, the 4th is installed between the 7th row micropore and the 8th row micropore
Bar magnet finally installs Article 5 magnet close to the side of panel sidewalls in the 9th row micropore.The magnetic frame again may be by
The mode of mobile a line realizes magnetic bead washing function.
The foregoing is a further detailed description of the present application in conjunction with specific implementation manners, and it cannot be said that this Shen
Specific implementation please is only limited to these instructions.For those of ordinary skill in the art to which this application belongs, it is not taking off
Under the premise of from the application design, a number of simple deductions or replacements can also be made.
Claims (8)
1. a kind of magnetic frame, it is characterised in that: including panel (1), magnetic stripe group (2) and bottom plate (3)；
The micropore for accommodating 96 hole PCR plates, the quantity of micropore column, i.e. panel more than 96 hole PCR plates are offered on the panel (1)
(1) 8 × 13 array micropores are provided on；
The magnetic stripe group (2) is made of seven bar magnets, and magnetic stripe group (2) is located between panel (1) and bottom plate (3), along micropore
Column direction, installation parallel with micropore column；Specifically, installing the first bar magnet, third between first row micropore and secondary series micropore
The second bar magnet is installed between column micropore and the 4th column micropore, and so on, between the 11st column micropore and the 12nd column micropore
Article 6 magnet is installed, Article 7 magnet finally is installed close to the side of panel sidewalls in the 13rd column micropore；
The bottom plate (3) is fastened on the back side of panel (1) by clamping or screw, plays a supportive role.
2. magnetic frame according to claim 1, it is characterised in that: in the magnetic stripe group (2), every corresponding bottom plate of bar magnet
(3) it is provided with several tightening screws (4) on position, the height of every bar magnet is realized by adjusting the height of tightening screw (4)
Adjustment.
3. a kind of magnetic frame, it is characterised in that: including panel (1), magnetic stripe group (2) and bottom plate (3)；
The micropore for accommodating porous plate, the quantity of micropore column, the i.e. battle array of porous plate more than porous plate are offered on the panel (1)
It is classified as n × m, then the microwell array on panel (1) is n × (m+1), wherein n is line number, m is columns；
The magnetic stripe group (2) is located between panel (1) and bottom plate (3), along the column direction of micropore, installation parallel with micropore column；
Specifically, installing the first bar magnet between first row micropore and secondary series micropore, pacify between third column micropore and the 4th column micropore
The second bar magnet is filled, and so on, if the micropore columns position odd number on panel (1), in last column micropore close to panel side
The side of wall is installed by the last item magnet；
The bottom plate (3) is fastened on the back side of panel (1) by clamping or screw, plays a supportive role.
4. magnetic frame according to claim 3, it is characterised in that: in the magnetic stripe group (2), every corresponding bottom plate of bar magnet
(3) it is provided with several tightening screws (4) on position, the height of every bar magnet is realized by adjusting the height of tightening screw (4)
Adjustment.
5. magnetic frame according to claim 3 or 4, it is characterised in that: the porous plate is 6 orifice plates, eight platoon pore of PCR
Plate, 12 orifice plates, 24 orifice plates or 48 orifice plates.
6. a kind of magnetic frame, it is characterised in that: including panel, magnetic stripe group and bottom plate；
The micropore for accommodating porous plate is offered on the panel, the quantity of micropore is compared with the more a line of porous plate, the i.e. array of porous plate
For n × m, then the microwell array on panel is (n+1) × m, wherein n is line number, m is columns；
The magnetic stripe group is located between panel and bottom plate, parallel with every row micropore to install along the line direction of micropore；Specifically,
First bar magnet is installed between the first row micropore and the second row micropore, Article 2 is installed between the third line micropore and fourth line micropore
Magnet, and so on, if the micropore line number position odd number on panel, installed in last line micropore close to the side of panel sidewalls
The last item magnet；
The bottom plate is fastened on the back side of panel by clamping or screw, plays a supportive role.
7. magnetic frame according to claim 6, it is characterised in that: in the magnetic stripe group, every corresponding bottom plate position of bar magnet
It sets and is provided with several tightening screws, the height adjustment of every bar magnet is realized by adjusting the height of tightening screw.
8. magnetic frame according to claim 6 or 7, it is characterised in that: the porous plate is 6 orifice plates, eight platoon pore of PCR
Plate, 12 orifice plates, 24 orifice plates or 48 orifice plates.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821657311.5U CN209292326U (en) | 2018-10-12 | 2018-10-12 | A kind of magnetic frame |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821657311.5U CN209292326U (en) | 2018-10-12 | 2018-10-12 | A kind of magnetic frame |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209292326U true CN209292326U (en) | 2019-08-23 |
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ID=67652769
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821657311.5U Active CN209292326U (en) | 2018-10-12 | 2018-10-12 | A kind of magnetic frame |
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| Country | Link |
|---|---|
| CN (1) | CN209292326U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112980648A (en) * | 2021-02-26 | 2021-06-18 | 浙江大学 | High-flux magnetic bead rapid transfer device |
-
2018
- 2018-10-12 CN CN201821657311.5U patent/CN209292326U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112980648A (en) * | 2021-02-26 | 2021-06-18 | 浙江大学 | High-flux magnetic bead rapid transfer device |
| CN112980648B (en) * | 2021-02-26 | 2023-02-28 | 浙江大学 | High-flux magnetic bead rapid transfer device |
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