CN209270629U - A kind of ultrasound transdermal electroporation circuit - Google Patents

Abstract

The utility model relates to a kind of ultrasonic transdermal electroporation circuit, the DC power supply for being 8V including output voltage, the DC power supply is connected with Voltage stabilizing module, boost module, and the Voltage stabilizing module is single-chip microcontroller, amplifier module for power supply；The output end of boost module is connected with two voltage-multiplying circuits, and two voltage-multiplying circuit is connected with pulse modulated circuit；In the ultrasound transdermal electroporation circuit, single-chip microcontroller can control signal by the first output end to amplifier module input voltage size between 0V -3.3V, according to the different voltages value of the output of the first output end of single-chip microcontroller, the size of the output voltage of boost module can control；The output voltage of boost module generates 16V to 110V electroporation pulse through pulse modulated circuit after the amplification of two voltage-multiplying circuits, the stepless continuous that electroporation pulse voltage size can be achieved is adjusted, the voltage swing that electroporation pulse can be adjusted according to the individual difference of patient over the course for the treatment of, mitigates the sense of discomfort of patient.

Description

A kind of ultrasound transdermal electroporation circuit

Technical field

The utility model relates to ultrasonic transdermal technology, especially a kind of ultrasonic transdermal electroporation circuit.

Background technique

Ultrasonic transdermal therapy, which refers to, promotes drug percutaneous or mucosa absorption using ultrasonic wave, is led to drug by physical method Organ and tissue that skin enters lesion are crossed, concentration is being partially formed, achievees the purpose that targeted therapy, the referred to as third generation are administered Mode.Ultrasonic transdermal can make target organ retain stable drug concentration close or higher with intravenously administrable, and the duration is more It is long, and blood concentration is extremely low, greatly reduces the systemic effect and adverse reaction of drug.Ultrasonic transdermal is that comprehensive utilization is electroluminescent Hole, ultrasonic wave and electro-ionic osmosis three combine, and realize percutaneously penetrating for drug.It is instantaneous using direction Medicine diffuser High-voltage pulse electric field new reversible hydrophilic pathway is generated between lipid and keratinocyte film between corneocyte, increase The infiltrative process of cell and cell membrane, ultrasonic transdermal therapy have the advantage that 1, electroporation is using transient high voltage Pulse, to skin zero damage, the duct of formation is temporary, reversible；2, it is administered using pulse mode, is advantageously implemented big point The transdermal penetration of sub- drug is administered；3, drug molecule can enter human body higher depth, be administered 5 to 10 centimetres of depth, can greatly increase The speed and quantity of dosing object cutaneous penetration；4, under the conditions of electroporation, the transdermal penetration amount of drug can be increased to 5~100 Times.

Electroporation circuit is an Important Circuit component part in ultrasonic transdermal instrument, its main feature is that highest needs are greater than The DC voltage of 100V, and in treatment because patient individual difference needs to be adjusted.But existing ultrasonic transdermal on the market Electroporation circuit this DC voltage value in instrument is usually a fixed value, and adjusting is to adjust pulse number, cannot be adjusted DC voltage value is saved, may cause that patient is uncomfortable, experience is poor over the course for the treatment of.Such as application No. is 201810038238.1, public affairs A kind of ultrasonic medicinal adjuvant therapy device disclosed in the Chinese patent document that day is 2018.06.29 is opened, including what is integrated Ultrasonic action pulse-generating circuit, electroporation pulse-generating circuit, electrical stimulation signal generation circuit and single-chip microcontroller, this document disclose Electroporation pulse-generating circuit equally exist the above-mentioned defect for not being adjustable DC voltage value.

Utility model content

The purpose of this utility model is to provide a kind of ultrasonic transdermal electroporation circuits, for solving existing ultrasonic transdermal instrument The electroporation circuit of device can only adjust pulse number, not be adjustable DC voltage value and cause to occur in patient treatment procedure uncomfortable The problem of sense.

To solve the above-mentioned problems, the utility model provides a kind of ultrasonic transdermal electroporation circuit, including output voltage is The DC power supply of 8V, the DC power supply are connected with Voltage stabilizing module, boost module, and the Voltage stabilizing module is single-chip microcontroller, amplifier mould Block power supply；First output end of the single-chip microcontroller is connected with the inverting input terminal of the amplifier module, the boost module it is defeated Outlet is connected with the non-inverting input terminal of the amplifier module, the output end of the amplifier module and the feedback letter of the boost module Number input terminal is connected；The output end of the boost module is connected with two voltage-multiplying circuits, two voltage-multiplying circuit and impulse modulation electricity Road is connected；The single-chip microcontroller is also connected respectively with the boost module, two voltage-multiplying circuit, the pulse modulated circuit to mention For controlling signal；The boosting enable end of the boost module is connected with the single-chip microcontroller, and the boost module can receive described The control signal of single-chip microcontroller and the output voltage for exporting 8V to 55V, the single-chip microcontroller can be to the fortune by the first output end Control signal of the amplification module input voltage size between 0V -3.3V, the amplifier module can relatively inverting input terminal, To the feedback signal input terminal of boost module output feedback signal to control the boosting mould after the voltage of non-inverting input terminal The output voltage of block.

Ultrasound transdermal electroporation circuit provided by the utility model also has following technical characteristic:

Further, the boost module uses XL6007 boost chip, and the amplifier module uses LWV358 chip, institute Voltage stabilizing module is stated using HI7533 chip.

Further, the output end of the boost module is connected with freewheeling diode, filter capacitor, the afterflow two in turn The output end of pole pipe is connected with the first divider resistance, the second divider resistance in turn, first divider resistance with described second point Be equipped with the connecting terminal that is connected with the non-inverting input terminal of the amplifier module between piezoresistance, first divider resistance with it is described The resistance value ratio of second divider resistance is 17:1.

Further, two voltage-multiplying circuit includes the first triode, the second triode, third transistor, the one or two pole Pipe, the second diode, third diode, first capacitor, the second capacitor and third capacitor；First triode uses positive-negative-positive Triode, second triode, the third transistor use NPN type triode；The output end of the freewheeling diode with The input terminal of the third diode is connected, and the output end of the third diode is by third capacity earth, and the described 3rd 2 The output end of pole pipe passes through first resistor and the base stage of first triode, the collector of the second triode, third transistor Base stage be connected, the grounded collector of first triode, the emitter of the first diode and the third transistor Emitter be connected after be connected with the cathode of the first capacitor, the emitter of second triode is grounded, the described 2nd 3 The base stage of pole pipe is connected by second resistance with single-chip microcontroller, and the collector of the third transistor is defeated with the third diode Outlet is connected, and the output end of the third diode is also connected with first diode, the output end of the first diode and institute The anode for stating first capacitor is connected, and the positive of the first capacitor is also connected with the two or two pole in turn between the third capacitor Pipe, the second capacitor, the output end of second diode are connected with the pulse modulated circuit.

Further, the pulse modulated circuit includes the 4th triode, the 5th triode, and the 4th triode uses PNP type triode, the 5th triode use NPN type triode；The emitter of 4th triode and two multiplication of voltage Circuit is connected, and 3rd resistor, the base stage of the 4th triode are connected between the emitter and base stage of the 4th triode It is connected by the 5th resistance with the collector of the 5th triode, the collector of the 4th triode exports electroporation arteries and veins Punching；The base stage of 5th triode is connected with the single-chip microcontroller by the 4th resistance to pass through single-chip microcontroller control action to human body Number of pulses, the 5th triode emitter ground connection.

The utility model has the following beneficial effects: Voltage stabilizing module, boost module, single-chip microcontroller, amplifier mould in the circuit Block, single-chip microcontroller can control signal by the first output end to amplifier module input voltage size between 0V -3.3V, according to The different voltages value of the output of first output end of single-chip microcontroller can control the size of the output voltage of boost module, realize boosting The output voltage of module is in 8V to can be adjustable according to the control stepless continuous of single-chip microcontroller between 55V；The output voltage of boost module 16V is generated to 110V electroporation pulse through pulse modulated circuit after the amplification of two voltage-multiplying circuits, and single-chip microcontroller can pass through impulse modulation The electroporation number of pulses of circuit control output；The circuit can be controlled the voltage swing of electroporation pulse by single-chip microcontroller, be realized The stepless continuous of electroporation pulse voltage size is adjusted, and can adjust electroporation arteries and veins according to the individual difference of patient over the course for the treatment of The voltage swing of punching mitigates the sense of discomfort of patient.

Detailed description of the invention

Fig. 1 is the circuit diagram of the ultrasonic transdermal electroporation circuit of the utility model embodiment；

Fig. 2 is the electrical block diagram of the ultrasonic transdermal electroporation circuit in the utility model embodiment.

Specific embodiment

The utility model is described in detail below with reference to attached drawing and in conjunction with the embodiments.It should be noted that not rushing In the case where prominent, the feature in the embodiments of the present invention and embodiment be can be combined with each other.

In one embodiment of the ultrasonic transdermal electroporation circuit of the utility model as shown in Figure 1 to Figure 2, the ultrasound is saturating Medicine electroporation circuit includes the DC power supply 10 that output voltage is 8V, and DC power supply 10 is connected with Voltage stabilizing module 20, boost module 30, Voltage stabilizing module 20 is single-chip microcontroller 40, amplifier module 50 provides the DC voltage of 3.3V；First output terminals A 3 of single-chip microcontroller 40 with The inverting input terminal of amplifier module 50 is connected, and the output end of boost module 30 is connected with the non-inverting input terminal of amplifier module 50, fortune The output end of amplification module 50 is connected with the feedback signal input terminal of boost module 30；The output end of boost module 30 is connected with two times Volt circuit 60, two voltage-multiplying circuits 60 are connected with pulse modulated circuit 70；Single-chip microcontroller 40 also respectively with 30, two times of piezoelectricity of boost module Road 60, pulse modulated circuit 70 are connected to provide and control signal；The boosting enable end A1 of boost module 30 is connected with single-chip microcontroller 40, Boost module 30 receives the control signal of single-chip microcontroller 40 and exports the output voltage of 8V to 55V, and single-chip microcontroller 40 passes through the first output End can compare instead to control signal of the 50 input voltage size of amplifier module between 0V -3.3V, amplifier module 50 Phase input terminal, non-inverting input terminal voltage after to the feedback signal input terminal A4 of boost module 30 export feedback signal with control rise The output voltage of die block 30.Specifically, comprising Voltage stabilizing module, boost module, single-chip microcontroller, amplifier module in the circuit, directly Galvanic electricity source 10 can use battery, lithium battery, alternating current can also be converted to DC power supply using power circuit, as long as can protect Demonstrate,prove stable 8V direct voltage output；Single-chip microcontroller can by the first output end to amplifier module input voltage size in 0V- Control signal between 3.3V can control boost module according to the different voltages value of the output of the first output end of single-chip microcontroller The size of output voltage realizes the output voltage of boost module in 8V to can be according to the control stepless continuous of single-chip microcontroller between 55V It is adjustable；The output voltage of boost module generates 16V to 110V electroporation arteries and veins through pulse modulated circuit after the amplification of two voltage-multiplying circuits Punching, single-chip microcontroller can control the electroporation number of pulses of output by pulse modulated circuit；The circuit can control electricity by single-chip microcontroller The voltage swing of pore pulse realizes that the stepless continuous of electroporation pulse voltage size is adjusted, can be over the course for the treatment of according to trouble The voltage swing of the individual difference adjustment electroporation pulse of person, mitigates the sense of discomfort of patient.

In one embodiment of the application, boost module 30 uses XL6007 boost chip, and amplifier module 50 uses LWV358 chip, Voltage stabilizing module 20 use HI7533 chip.In the embodiment, the DC power supply of 8V is through the HI7533 of Voltage stabilizing module The DC-voltage supply of 3.3V is provided for single-chip microcontroller 40 and amplifier module 50 after chip (VR1) decompression, the DC power supply of 8V is another Road enters boost module 30 and boosts, and boost module 30 is using the switch that XL6007 boost chip is that Shanghai Godson company produces Step-up DC-DC conversion chip, the chip have outstanding line regulation and load regulation, and maximum output voltage is reachable 60V, the chip interior integrate the reliability modules such as overcurrent protection, overheat protector, SW overvoltage protection, and XL6007 boost chip is adopted It is SOP-8L encapsulation, it is flexible in application using standard external components.

In one embodiment of the application, the output end of boost module 30 is connected with sustained diode 4, filtering in turn Capacitor C4, the output end of sustained diode 4 are connected with the first divider resistance R8, the second divider resistance R7, the first partial pressure electricity in turn The connecting terminal being connected with the non-inverting input terminal of amplifier module 50, the second partial pressure electricity are equipped between resistance R8 and the second divider resistance R7 It hinders R7 to be grounded, the resistance value ratio of the first divider resistance R8 and the second divider resistance R7 are 17:1, specifically, the first partial pressure electricity The resistance value for hindering R8 is 34K Ω, and the resistance value of the second divider resistance R7 is 2K Ω；By the way that sustained diode 4, filtered electrical is arranged Holding C4 can guarantee that the tie point A2 between sustained diode 4, filter capacitor C4 obtains stable output voltage；To boost mould The output voltage of block 30 inputs the homophase input of amplifier module 50 after dividing by the first divider resistance R8, the second divider resistance R7 End, amplifier module relatively non-inverting input terminal, inverting input terminal signal after export high and low level signal to boost module 30 Thus feedback signal input terminal A4 can be further ensured that the output voltage that boost module is stable, reliably exports needs.In the reality It applies in example, the first output terminals A 3 output for the single-chip microcontroller being connected with the inverting input terminal of amplifier module 50 can be single-chip microcontroller DA The voltage of module output is also possible to the voltage of single-chip microcontroller output pwm pulse after processing, the voltage output of the first output terminals A 3 Amplitude controls determination between 3.3V and by single-chip microcontroller in 0V；Amplifier module 50 is used as comparator in this embodiment, Non-inverting input terminal voltage and inverting input terminal voltage obtain a high and low level signal, in-phase end in output end after comparator High level is exported when higher than reverse side, otherwise output low level, this level input boost module through feedback signal input terminal A4 30 feedback foot, to control the output voltage of tie point A2 by boost module 30.

In one embodiment of the application, it is preferable that two voltage-multiplying circuits 30 include the first triode Q1, the second triode Q2, third transistor Q3, first diode D1, the second diode D2, third diode D3, first capacitor C1, the second capacitor C2 With third capacitor C3；First triode Q1 uses PNP type triode, and the second triode Q2, third transistor Q3 use NPN type three Pole pipe；The output end of sustained diode 4 is equipped with the tie point A2 being connected with the input terminal of third diode D3, third diode The output end of D3 is grounded by third capacitor C3, and the output end of third diode D3 passes through first resistor R1 and the first triode Q1 Base stage, the collector of the second triode Q2, third transistor Q3 base stage be connected, the grounded collector of the first triode Q1, The emitter of first diode D1 is connected after being connected with the emitter of third transistor Q3 with the cathode of first capacitor C1, and the two or three The emitter of pole pipe Q2 is grounded, and the base stage of the second triode Q2 is connected by second resistance R2 with single-chip microcontroller, and second resistance R2 connects It is connected to the terminals A5 for being connected with single-chip microcontroller, the output end phase of the collector and third diode D3 of third transistor Q5 Even, the output end of third diode D3 is also connected with first diode D1, the output end and first capacitor C1 of first diode D1 Anode be connected, be also connected with the second diode D2, the second capacitor in turn between the anode and third capacitor C3 of first capacitor C1 The output end of C2, the second diode D2 are connected with pulse modulated circuit；Specifically, the pwm pulse of single-chip microcontroller is from terminals A5 Input is connected Q2 interval, so as to cause Q1 and Q3 alternate conduction, has finally obtained 2 times of companies in the anode of first capacitor C1 Voltage at contact A2 obtains the voltage value exported as needed within the scope of 16V to 110V in the anode of first capacitor C1.

In one embodiment of the application, it is preferable that pulse modulated circuit 70 includes the 4th triode Q4, the five or three pole Pipe Q5, the 4th triode Q4 use PNP type triode, and the 5th triode Q5 uses NPN type triode；The hair of 4th triode Q4 Emitter-base bandgap grading is connected with the output end of the second diode D2 in two voltage-multiplying circuits, connects between the emitter and base stage of the 4th triode Q4 It is connected to 3rd resistor R3, the base stage of the 4th triode Q4 is connected by the 5th resistance R5 with the collector of the 5th triode Q5, the The collector of four triode Q4 is connected with the terminals A7 for exporting electroporation pulse；The base stage of 5th triode Q5 passes through the Four resistance R4 be connected with single-chip microcontroller with by single-chip microcontroller control action arrive human body number of pulses, the 4th resistance equipped with for list The emitter ground connection of piece machine connected terminals A6, the 5th triode Q5；Thus the voltage signal that two voltage-multiplying circuits can be generated It is modulated into electroporation pulse, the number of pulses of terminals A6 control, adjusting output is passed through by single-chip microcontroller.

Finally, it should be noted that above embodiments are only to illustrate the technical solution of the utility model, rather than its limitations； Although the utility model is described in detail with reference to the foregoing embodiments, those skilled in the art should understand that: It is still possible to modify the technical solutions described in the foregoing embodiments, or part of technical characteristic is carried out etc. With replacement；And these are modified or replaceed, various embodiments of the utility model technology that it does not separate the essence of the corresponding technical solution The spirit and scope of scheme.

Claims (5)

1. a kind of ultrasound transdermal electroporation circuit, the DC power supply for being 8V including output voltage, which is characterized in that the direct current Source is connected with Voltage stabilizing module, boost module, and the Voltage stabilizing module is single-chip microcontroller, amplifier module for power supply；The first of the single-chip microcontroller Output end is connected with the inverting input terminal of the amplifier module, the same phase of the output end of the boost module and the amplifier module Input terminal is connected, and the output end of the amplifier module is connected with the feedback signal input terminal of the boost module；The boosting mould The output end of block is connected with two voltage-multiplying circuits, and two voltage-multiplying circuit is connected with pulse modulated circuit；The single-chip microcontroller is also distinguished It is connected with the boost module, two voltage-multiplying circuit, the pulse modulated circuit to provide and control signal；The boost module Boosting enable end be connected with the single-chip microcontroller, the boost module can receive the control signal of the single-chip microcontroller and export 8V To the output voltage of 55V, the single-chip microcontroller can be to the amplifier module input voltage size in 0V-by the first output end Control signal between 3.3V, the amplifier module can relatively inverting input terminal, non-inverting input terminal voltage after Xiang Suoshu The feedback signal input terminal of boost module exports feedback signal to control the output voltage of the boost module.

2. ultrasound transdermal electroporation circuit according to claim 1, it is characterised in that: the boost module uses XL6007 Boost chip, the amplifier module use LWV358 chip, and the Voltage stabilizing module uses HI7533 chip.

3. ultrasound transdermal electroporation circuit according to claim 2, it is characterised in that: the output end of the boost module according to Secondary to be connected with freewheeling diode, filter capacitor, the output end of the freewheeling diode is connected with the first divider resistance, second in turn Divider resistance is equipped with the non-inverting input terminal with the amplifier module between first divider resistance and second divider resistance The resistance value ratio of connected connecting terminal, first divider resistance and second divider resistance is 17:1.

4. ultrasound transdermal electroporation circuit according to claim 3, it is characterised in that: two voltage-multiplying circuit includes first Triode, the second triode, third transistor, first diode, the second diode, third diode, first capacitor, the second electricity Hold and third capacitor；First triode uses PNP type triode, and second triode, the third transistor use NPN type triode；The output end of the freewheeling diode is connected with the input terminal of the third diode, the third diode Output end by third capacity earth, the output end of the third diode passes through first resistor and first triode Base stage, the collector of the second triode, the base stage of third transistor are connected, and the grounded collector of first triode is described The emitter of first diode is connected after being connected with the emitter of the third transistor with the cathode of the first capacitor, described The emitter of second triode is grounded, and the base stage of second triode is connected by second resistance with single-chip microcontroller, the third The collector of triode is connected with the output end of the third diode, and the output end of the third diode is also connected with first Diode, the output end of the first diode are connected with the anode of the first capacitor, the anode of the first capacitor and institute It states and is also connected with the second diode, the second capacitor between third capacitor in turn, the output end and the arteries and veins of second diode Modulated circuit is connected.

5. ultrasound transdermal electroporation circuit according to claim 4, it is characterised in that: the pulse modulated circuit includes the Four triodes, the 5th triode, the 4th triode use PNP type triode, and the 5th triode uses three pole of NPN type Pipe；The emitter of 4th triode is connected with two voltage-multiplying circuit, the emitter of the 4th triode and base stage it Between be connected with 3rd resistor, the base stage of the 4th triode passes through the collector phase of the 5th resistance and the 5th triode Even, the collector of the 4th triode exports electroporation pulse；The base stage of 5th triode passes through the 4th resistance and institute Single-chip microcontroller is stated to be connected through the number of pulses of single-chip microcontroller control action to human body, the emitter ground connection of the 5th triode.