CN209252838U - A kind of integration aptitude tests platform for cerebral ischemia mouse - Google Patents
A kind of integration aptitude tests platform for cerebral ischemia mouse Download PDFInfo
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Abstract
The utility model discloses a kind of integration aptitude tests platforms for cerebral ischemia mouse, including main platform body, main platform body includes the glass box body and stabilizer blade of hollow upper end opening, glass box body is mounted on the upper surface of stabilizer blade, and creep mechanism for testing, grid of weight bearing is equipped in glass box body and is creeped mechanism for testing, water maze mechanism for testing and suspension mechanism for testing；Grid mechanism for testing of creeping includes cushion and grid is creeped test suite, and cushion is set to grid and creeps the lower section of test suite；Suspension mechanism for testing includes neonychium and suspension test suite, and suspension test suite is set to the top of neonychium.There is the utility model creep mechanism for testing, grid of weight bearing to creep mechanism for testing, water maze mechanism for testing and suspension mechanism for testing, and it is single to solve original experimental provision mechanism for testing, the insufficient problem of Germicidal efficacy data；The setting of the cushion and neonychium of the utility model solves the problems, such as that mouse falls rear easy tumble injury in original experimental provision experimentation.
Description
Technical field
The utility model relates to animal movement integration ability test devices, more particularly to one kind to be used for cerebral ischemia mouse
Integration aptitude tests platform.
Background technique
Ischemic brain damage is blocked by cerebral vessels so that a kind of irreversible damage that the blood vessel institute blood supply brain area occurs
Wound.The disease has become global first big disabling disease, the third-largest fatal disease.The main group of people at high risk of the disease is 50 years old
Later crowd, its group of people at high risk has the tendency that tending to rejuvenation at present.The disease, which has become, to threaten human health and influences to give birth to
An important factor for bioplasm amount.Ischemic brain damage has become the coke of global Neuscience basis and clinical staff concern
Point.
Brain in addition to the basic functions such as feeling, movement of main department organism or the high-level center of organism, as emotion,
Decision, memory etc..Brain tissue is stored in the skull chamber interior being made of hard skull, carries out blood supply by blood vessel, provides feeding
Material, oxygen simultaneously take away metabolic waste.Due to the presence of blood-brain barrier, molecule present in some peripheral bloods enters less than in brain,
It ensure that the normal operation of brain.But some molecules are can be carried out in cerebral vessels by blood-brain barrier, such as lipid
Accumulation, causes local vascular chamber to narrow, these will cause potential cerebral ischemia inducement.
Animal Behavior Science detection is that whether assessment Animal Model is successful and whether means of intervention effective one have
Power tool is especially used widely in Neurobiology field, it can not only change the pathology after nervous system injury
Become in the case where not carrying out sacrifice materials to experimental subjects, the change of corresponding brain area can be shown by the change in behaviouristics
Change, it can also be by the corresponding function situation of brain area progress showing incisively and vividly.Therefore, Animal Behavior Science is than simple tissue disease
Reason slice, dyeing, protein purification concentration mensuration and nucleic acid extraction and measurement more have convincingness, and in terms of functional rehabilitation
It is even more that there is irreplaceable role in terms of effect monitoring.
In mammalian laboratory animals, since mouse is small, feeding management is convenient, and easily controllable, Reproduction is fast, has
Specific quality control standard, therefore in each subject experimental study, dosage is maximum, and purposes is most wide.In addition, scientist is completed
95% murine genes atlas analysis can find corresponding base by comparing the murine genes of discovery 99% in human body gene
Cause, therefore, mouse pass through the experimental subjects frequently as physianthropy basic research.
For Forebrain Ischemia current state of experimental research is worked as, using the male mouse that grows up as experimental animal, notification number is
The Chinese patent of CN205072870U discloses a kind of integration aptitude tests device for cerebral ischemia mouse, the dress
It sets and is made of support section, hollow out grid part of detecting, support section bottom connects rubber suction cups, and hollow out grid test department sets up separately
It counts and is suitble to experiment mice figure, born a heavy burden during the test by statistical experiment animal and make a misstep situation, its motor function is damaged
It is evaluated.Which solves the animal model selections in the pathogenesis of ischemic brain damage and drug screening process
Professional poor, the skimble-scamble problem of designed, designed standard, provides effective data supporting for the development of all kinds of related experiments；But
In practice, there are still following defects for the device:
1) mechanism of integration aptitude tests is single, can not carry out kinds of experiments analysis；
2) hollow out grid part of detecting does not have safeguard function, and mouse has the danger for falling tumble injury during the motion.
Utility model content
The purpose of the utility model is to provide a kind of integration aptitude tests platform for cerebral ischemia mouse, with
Solve the technical issues of proposing in background technique.
The above-mentioned technical purpose of the utility model has the technical scheme that
A kind of integration aptitude tests platform for cerebral ischemia mouse, including main platform body, the platform master
Body includes that the glass box body of hollow upper end opening and stabilizer blade, the glass box body are mounted on the upper surface of the stabilizer blade, the glass
Creep mechanism for testing, grid of weight bearing is equipped in glass cabinet to creep mechanism for testing, water maze mechanism for testing and suspension mechanism for testing；
Weight bearing mechanism for testing of creeping includes non-slip mat and weight bearing is creeped test suite, the non-slip mat and the glass
The bottom of cabinet connects, and weight bearing test suite of creeping is set to the non-slip mat top, and the weight bearing is creeped test suite
Including slender U-shaped channel, weight bearing trolley, fixed pulley one, fixed pulley two, fixed pulley three and fixed pulley four；One He of fixed pulley
Fixed pulley two is relatively arranged at the marginal position at the non-slip mat both ends, and the slender U-shaped channel is set to the fixed pulley
Between one and fixed pulley two；The slender U-shaped channel is made of three pieces of glass plates, has a rectangular aperture, described slender U-shaped logical
The rectangular aperture end in road is connect with the non-slip mat, the slender U-shaped channel close to fixed pulley one and far from fixed pulley one one
End is respectively formed opening；The fixed pulley three is located at the slender U-shaped channel close to the top of one one end of fixed pulley, the fixed pulley
Four are located at the slender U-shaped channel close to the top of two one end of fixed pulley, and the weight bearing trolley is located at the top of the non-slip mat
And it is connected with drawstring；
Grid mechanism for testing of creeping includes cushion and grid is creeped test suite, and the grid is creeped test suite packet
Two pieces of transparent support plates and test grid are included, two pieces of transparent support plates are vertical with the bottom of the glass box body, described
Two pieces of transparent support plates are formed in the bottom of mirror settings and lower end and the glass box body and are detachably connected, and the Test Network is set
At medium position between two pieces of transparent support plates, the cushion is layed in the glass box below the Test Network
The bottom of body；
The water maze mechanism for testing includes pond and the half space of hollow upper end opening, if the basin bottom is equipped with
Dry jack, the lower end of the half space are inserted in the jack；
The suspension mechanism for testing includes neonychium and suspension test suite, and the neonychium is layed in the glass box body
Bottom, it is described suspension test suite be set to the neonychium top；The suspension test suite include two support rods and
Wirerope, two support rods are in mirror settings in the two sides of the neonychium, and the lower end of two support rods is and institute
The bottom connection of glass box body is stated, the both ends of the wirerope are connect with the top of two support rods respectively.
The utility model is further arranged to: cross partition, the cross partition are equipped in the glass box body
The glass box body is separated into one area of equal-sized test, 4th area of 2nd area of test, 3rd area of test and test；The weight bearing is climbed
Row mechanism for testing is set in one area of the test, and the grid creeps mechanism for testing in 2nd area of the test, the water fan
Palace mechanism for testing is set in 3rd area of the test, and the suspension mechanism for testing is set in 4th area of the test.
The utility model is further arranged to: the weight bearing trolley is made of mobile chassis and car body, the car body peace
Top loaded on the mobile chassis, the car body are equipped with the object placing cavity of upper end opening.
The utility model is further arranged to: the car body is equipped with opening towards the dark hole of the fixed pulley one.
The utility model is further arranged to: the bottom of the glass box body set there are two with two pieces of transparent supports
The card slot of the lower end adaptation of plate, the lower end of two pieces of transparent support plates is connected in corresponding card slot respectively；The Test Network includes
Grid frame and steel wire, the steel wire are mounted on inside the grid frame, in the inside of two pieces of transparent support plates
Portion is horizontally arranged with slot, and the both ends of the Test Network are inserted in corresponding slot respectively.
The utility model is further arranged to: the Grid Edge outer frame is exposed to wherein one end of the slot to extension
It stretches, forms the pickup platform for picking up mouse；One of transparent support plate is connected with far from described one end for picking up platform
Platform for video camera, at the medium position between the Test Network and cushion, the both ends of the cushion extend the platform for video camera
It is exposed to except the both ends of the slot at least 15cm to the Grid Edge outer frame.
The utility model is further arranged to: the jack circularizes array distribution in the bottom in the pond, described
The top of pool edge is equidistantly equipped with four label columns.
In conclusion the utility model has the following beneficial effects:
One, the utility model have weight bearing creep mechanism for testing, grid creep mechanism for testing, water maze mechanism for testing and
Mechanism for testing is hung, it is single to solve original experimental provision mechanism for testing, the insufficient problem of Germicidal efficacy data；
Secondly, the grid of the utility model creep mechanism for testing equipped with cushion, suspension mechanism for testing is equipped with neonychium, solves
The problem of mouse falls rear easy tumble injury in original experimental provision experimentation；
Thirdly, the design of the glass box body of the utility model realize the safeguard function of mouse in experimentation, can avoid
Mouse falls from main platform body, solves the problems, such as artificially must carefully nurse mouse when the experiment of original device；
Four, the utility model grid is creeped the design of mechanism for testing, realizes the convenience of transparent support plate and Test Network
It removes and installs, Test Network can be removed and be cleaned.
Detailed description of the invention
Fig. 1 is the overall structure diagram of the utility model；
Fig. 2 is the top view of glass box body in Fig. 1；
Fig. 3 is that the weight bearing of the utility model is creeped the overall structure diagram of mechanism for testing；
Fig. 4 is that the grid of the utility model is creeped the overall structure diagram of mechanism for testing；
Fig. 5 is the overall structure diagram of the water maze mechanism for testing of the utility model；
Fig. 6 is the overall structure diagram of the suspension mechanism for testing of the utility model.
In figure: 1, main platform body；11, glass box body；12, stabilizer blade；13, an area is tested；14,2nd area are tested；141, block
Slot；15,3rd area are tested；16,4th area are tested；17, cross partition；2, bear a heavy burden mechanism for testing of creeping；21, non-slip mat；22, strip
U-shaped channel；23, bear a heavy burden trolley；231, mobile chassis；232, car body；233, object placing cavity；234, dark hole；24, fixed pulley one；
25, fixed pulley two；26, fixed pulley three；27, fixed pulley four；28, drawstring；3, grid is creeped mechanism for testing；31, cushion；32, thoroughly
Bright support plate；321, slot；322, platform for video camera；33, Test Network；331, grid frame；332, steel wire；333, it picks up flat
Platform；4, water maze mechanism for testing；41, pond；42, half space；43, jack；44, column is marked；5, mechanism for testing is hung；51,
Neonychium；52, support rod；53, wirerope.
Specific embodiment
The utility model is described in further detail below in conjunction with attached drawing.
In the description of the present invention, it should be noted that the orientation of the instructions such as term " on ", "lower", "inner", "outside"
Or positional relationship be based on the orientation or positional relationship shown in the drawings or the utility model product using when usually put
Orientation or positional relationship is merely for convenience of describing the present invention and simplifying the description, rather than the dress of indication or suggestion meaning
It sets or element must have a particular orientation, be constructed and operated in a specific orientation, therefore should not be understood as to the utility model
Limitation.
In addition, term " first ", " second ", " third " etc. are only used for distinguishing description, it is not understood to indicate or imply
Relative importance；Term " vertical " is not offered as that component is required absolutely to dangle, but can be slightly tilted.
In the description of the present invention, it should also be noted that, unless otherwise clearly defined and limited, term " is set
Set ", " installation ", " connected ", " connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection,
Or it is integrally connected；It can be mechanical connection, be also possible to be electrically connected；It can be directly connected, intermediary can also be passed through
It is indirectly connected, can be the connection inside two elements.For the ordinary skill in the art, it can be managed with concrete condition
Solve the concrete meaning of above-mentioned term in the present invention.
Embodiment one:
A kind of integration aptitude tests platform for cerebral ischemia mouse, as shown in Fig. 1-Fig. 6, including platform
Main body 1, main platform body 1 include that the glass box body 11 of hollow upper end opening and stabilizer blade 12, glass box body 11 are mounted on stabilizer blade 12
Upper surface, the setting of glass box body 11 avoid experiment mice and fall from main platform body 1；Specifically, stabilizer blade 12 is provided with four
Root, the upper end of four stabilizer blades 12 are connect with the lower end quadrangle of glass box body 11；The test machine of creeping that bears a heavy burden is equipped in glass box body 11
Structure 2, grid creep mechanism for testing 3, water maze mechanism for testing 4 and suspension mechanism for testing 5.
Preferably, in order to avoid experiment mice weight bearing creep mechanism for testing 2, grid creep mechanism for testing 3, water maze survey
It runs chaotically between test-run a machine structure 4 and suspension mechanism for testing 5, cross partition 17, cross is equipped in the glass box body 11 of the utility model
Glass box body 11 is separated into one area 13 of equal-sized test, two areas 14 of test, three areas 15 of test and test four by shape partition 17
Area 16；Weight bearing creeps mechanism for testing 2 in one area 13 of test, and grid creeps mechanism for testing 3 in two areas 14 of test, water fan
Palace mechanism for testing 4 is set in three areas 15 of test, and suspension mechanism for testing 5 is set in four areas 16 of test.
The weight bearing of the utility model mechanism for testing 2 of creeping includes that non-slip mat 21 and weight bearing are creeped test suite, non-slip mat 21
It is connect with the bottom of glass box body 11, weight bearing test suite of creeping is set to 21 top of non-slip mat, and specifically, non-slip mat 21 is adopted
The bottom for being made of natural rubber and glue being used to be adhered to glass box body 11, avoids experiment mice when creeping in glass box body
It skids in 11, the top of non-slip mat 21 is set creeps test suite there are four weight bearing, it is to be understood that the weight bearing is creeped test
Component may also set up two, three or more, convenient for the gait difference of observation experiment group mouse and control group mice, improve experiment
Efficiency；Weight bearing creep test suite include slender U-shaped channel 22, it is weight bearing trolley 23, fixed pulley 1, fixed pulley 2 25, fixed sliding
3 26 and fixed pulley 4 27 are taken turns, fixed pulley 1 and fixed pulley 2 25 are relatively arranged at the marginal position at 21 both ends of non-slip mat,
Slender U-shaped channel 22 is set between fixed pulley 1 and fixed pulley 2 25；Slender U-shaped channel 22 is made of three pieces of glass plates,
With a rectangular aperture, the rectangular aperture end in slender U-shaped channel 22 is connect with non-slip mat 21, and slender U-shaped channel 22 is close to fixed sliding
It takes turns 1 and is respectively formed opening far from one end of fixed pulley 1, specifically, the rectangular aperture end use in slender U-shaped channel 22
Glue is connect with non-slip mat 21；Fixed pulley 3 26 is located at top of the slender U-shaped channel 22 close to one 24 one end of fixed pulley, fixed pulley
4 27 are located at slender U-shaped channel 22 close to the top of 2 25 one end of fixed pulley, the trolley 23 that bears a heavy burden be located at the top of non-slip mat 21 and
It is connected with drawstring 28；Specifically, one end of drawstring 28 is connect with weight bearing trolley 23 far from one end of fixed pulley 1, drawstring
28 other end is free end, and weight bearing trolley 23 is made of mobile chassis 231 and car body 232, and mobile chassis 231 is played using common
Has the chassis of trolley, car body 232 is installed on the top of mobile chassis 231, and car body 232 is equipped with the glove of upper end opening
Chamber 233, convenient for weight to be placed in object placing cavity 233, creeping to test for mouse weight bearing is used.
Preferably due to muroid has the characteristics that like dark, and in order to which preferably Induction experiments mouse creeps forward, car body
232 are equipped with opening towards the dark hole 234 of fixed pulley 1.
The grid of the utility model mechanism for testing 3 of creeping includes that cushion 31 and grid are creeped test suite, and grid is creeped survey
Trying component includes 33 lattice of two pieces of transparent support plates 32 and Test Network, and two pieces of transparent support plates 32 hang down with the bottom of glass box body 11
Directly, two pieces of transparent support plates 32 are formed in the bottom of mirror settings and lower end and glass box body 11 and are detachably connected, Test Network 33
It is set at the medium position between two pieces of transparent support plates 32, cushion 31 is set to 33 lower section of Test Network；Specifically, it surveys
Trying net 33 includes grid frame 331 and steel wire 332, and steel wire 332 is mounted on inside grid frame 331, the net of steel wire 332
Lattice are the rectangular mesh of 10cm × 7cm, and the bottom of glass box body 11 sets the lower end there are two with two pieces of transparent support plates 32
The card slot 141 of adaptation, the lower end of two pieces of transparent support plates 32 are connected in corresponding card slot 141 respectively, two pieces of transparent support plates 32
Middle inside is equipped with slot 321, and the both ends of Test Network 33 are inserted in corresponding slot 321 respectively, convenient for removing Test Network 33
It is cleaned, cushion 31 is made of sponge, is layed in the bottom of glass box body 11, is convenient for cleaning replacement, the setting of cushion 31
Protection can be formed to the mouse fallen from Test Network 33, avoid mouse by tumble injury.
Preferably, in order to pick up mouse in experiment, grid frame 331 expose to wherein one end of slot 321 to
Outer extension forms the pickup platform 333 for picking up mouse.
Preferably, one of transparent support plate 32 is connected with platform for video camera 322 far from the one end for picking up platform 333, takes the photograph
As platform 322 is at the medium position between Test Network 33 and cushion 31；In experiment one can be placed on platform for video camera 322
Platform video camera enrolls the video that one minute mouse creeps in Test Network 33, is observed convenient for after the end of the experiment by video small
The motion conditions of mouse, the front and back limb for counting mouse make a misstep step number.
Preferably, the both ends of cushion 31 extend to grid frame 331 and expose to except the both ends of slot 321 at 15cm；It keeps away
Exempt from after experiment mice is fallen from the both ends that grid frame 331 exposes to slot 321 by tumble injury.
The water maze mechanism for testing 4 of the utility model includes pond 41 and the half space 42 of hollow upper end opening, pond
41 bottoms are equipped with several jacks 43, and the lower end of half space 42 is inserted in jack 43；Specifically, the pond 41 is held on glass
The bottom upper end of glass cabinet 11, the experimental water being conveniently replaceable in pond 41, the pond 41 use depth for the circle of 20cm
Pond 41, jack 43 circularize array distribution in the bottom in pond 41, and jack 43 is circular hole, half space 42 use highly for
The lower end of the cylindric platform of 7cm, half space 42 is cylindric to be adapted to the circular hole, convenient for disassembly and assembly, it is envisaged that
It is that the half space 42 can also be quadrangular shape or pentagonal prism shape.
Preferably, the top at 41 edge of pond is equidistantly equipped with four label columns 44；Convenient for the place of entry of unified mouse.
The suspension mechanism for testing 5 of the utility model includes neonychium 51 and suspension test suite, and neonychium 51 is layed in glass
The bottom of glass cabinet 11, is convenient for cleaning replacement neonychium 51, and suspension test suite is set to the top of neonychium 51；Hang test group
Part includes two support rods 52 and wirerope 53, and two support rods 52 are in mirror settings in the two sides of neonychium 51, two supports
The lower end of bar 52 is connect with the bottom of glass box body 11, and the both ends of wirerope 53 connect with the top of two support rods 52 respectively
It connects, specifically, the top of neonychium 51 is set there are three test suite is hung, convenient for the upper of observation experiment group and control group mice
Limb grasps situation difference.
Embodiment two:
The feature that the present embodiment is the same as example 1 repeats no more, and the present embodiment feature different from embodiment one exists
In:
As shown in figs 1 to 6, the top of non-slip mat 21 is set there are two the test suite of creeping that bears a heavy burden, and the both ends of cushion 31 extend
Exposed to grid frame 331 except the both ends of slot 321 at 16cm, the top of neonychium 51 set there are two hang test group
Part.
Embodiment three:
The feature that the present embodiment is the same as example 1 repeats no more, and the present embodiment feature different from embodiment one exists
In:
As shown in figs 1 to 6, the top of non-slip mat 21 is set there are three the test suite of creeping that bears a heavy burden, and the both ends of cushion 31 extend
Exposed to grid frame 331 except the both ends of slot 321 at 17cm, the top of neonychium 51 set there are two hang test group
Part.
Wherein optimal scheme is embodiment two, and test suite setting two of creeping of bearing a heavy burden can both carry out experimental group simultaneously
Experiment and control group experiment, and save space；The both ends of cushion 31 extend to two that grid frame 331 exposes to slot 321
Except end at 16cm, enough to fall mouse formed protection；The top of neonychium 51 is set there are two test suite is hung,
Experiment demand is met, does not need that excessive suspension test suite is arranged.
Usage mode:
A. weight bearing is creeped experiment: referring to figs. 1 to Fig. 3,
Weight bearing creep test suite one end place a video camera, in case experimentation video recording use.
Experimental group a: weight bearing trolley 23 is placed in slender U-shaped channel 22 close to the place open at one end of fixed pulley 1, by brain
The experiment of ischemic injuries is placed between fixed pulley 1 and weight bearing trolley 23 with adult male mice, later again by drawstring 28
Free end successively bypass fixed pulley 2 25, fixed pulley 4 27, fixed pulley 3 26 and fixed pulley 1, finally tighten drawstring 28,
The free end of drawstring 28 is fixed on the experiment adult male mice of cerebral ischemia, when it is trained experiment at
When year male mice is creeped to one end of fixed pulley 2 25, video camera is opened, one minute video data is recorded, records and analyzes
The Crawl gait of laboratory mice and step number of creeping.
Control group a: changing the experiment of cerebral ischemia into normal experiment adult male mice with adult male mice,
It is tested using mode identical with experimental group a, records and analyzes experimental data；Finally again by experimental group a's and control group a
Experimental data compares, and analysis cerebral ischemia creeps the influence of ability to mouse.
B. grid is creeped experiment: referring to figs. 1 to Fig. 4,
In one video camera of upper ends of platform for video camera 322, in case experimentation video recording uses.
Experimental group b: the experiment of cerebral ischemia being placed in adult male mice and picks up platform 333, when by training
Experiment started with adult male mice when creeping in Test Network 33, open video camera, record one minute video data, note
It records and the front and back limb for analyzing laboratory mice makes a misstep step number.
Control group b: changing the experiment of cerebral ischemia into normal experiment adult male mice with adult male mice,
It is tested using mode identical with experimental group b, records and analyzes experimental data；Finally again by experimental group b's and control group b
Experimental data compares, and analyzes influence of the cerebral ischemia to mouse balanced capacity.
C. water maze laboratory: referring to figs. 1 to Fig. 5,
Experimental group c: half space 42 is fixed on one of jack 43 in pond 41, records jack by the first stage
25~30 DEG C of warm water is injected in 43 position in pond 41, and the water surface is more than the upper surface 8cm of half space 42, and mouse stops
Head is lifted and can be breathed in water on breath platform 42；The experiment of cerebral ischemia is used from one of label 44 position of column
Adult male mice towards 41 side wall of pond into the water, the position of recording mark column 44；It is male with adult to observe and record experiment
Property mouse finds the path for being hidden in the half space 42 of underwater and required used time；Second stage removes half space 42, will
The experiment adult male mice of cerebral ischemia from any one label 44 position of column from towards 41 side wall of pond into the water,
Experiment is observed and recorded to find the path of original platform with adult male mice and reach the needed used time at original position of platform.
Control group c: changing the experiment of cerebral ischemia into normal experiment adult male mice with adult male mice,
Tested using mode identical with experimental group c, wherein it should be noted that control group c in the first stage and second stage
Half space 42 position and the water position that enters of mouse need to be identical with experimental group c, record and analyze experimental data；Finally again will
Experimental group c and the experimental data of control group c compare, and analyze influence of the cerebral ischemia to mouse spatial memory capacity.
D. suspension experiment: referring to figs. 1 to Fig. 6,
Experimental group d: the forelimb by the experiment of cerebral ischemia adult male mice is allowed to grip wirerope 53, observation is simultaneously
The number that the forelimb of laboratory mice slips in record one minute.
Control group d: changing the experiment of cerebral ischemia into normal experiment adult male mice with adult male mice,
It is tested using mode identical with experimental group d, records and analyzes experimental data；Finally again by experimental group d's and control group d
Experimental data compares, and analyzes influence of the cerebral ischemia to mouse grippage.
Above-described embodiment is only the section Example of the utility model, not makees any form to the utility model
On limitation；Anyone skilled in the art all can benefit in the case where not departing from technical solutions of the utility model ambit
Many possible changes and modifications, or modification are made to technical solutions of the utility model with the methods and technical content of the disclosure above
For the equivalent embodiment of equivalent variations.Therefore, all contents without departing from technical solutions of the utility model, according to the utility model
Technical spirit any simple modification, equivalent replacement, equivalence changes and modification made to the above embodiment, still fall within this reality
In the range of the protection of new technique scheme.
Claims (7)
1. a kind of integration aptitude tests platform for cerebral ischemia mouse, including main platform body (1), feature exists
In: the main platform body (1) includes the glass box body (11) and stabilizer blade (12) of hollow upper end opening, glass box body (11) peace
Creep mechanism for testing (2), grid of weight bearing is equipped with mounted in the upper surface of the stabilizer blade (12), in the glass box body (11) to creep survey
Test-run a machine structure (3), water maze mechanism for testing (4) and suspension mechanism for testing (5)；
Weight bearing mechanism for testing (2) of creeping includes non-slip mat (21) and weight bearing is creeped test suite, the non-slip mat (21) and
The bottom of the glass box body (11) connects, and weight bearing test suite of creeping is set to the non-slip mat (21) top, described
Weight bearing creep test suite include slender U-shaped channel (22), it is weight bearing trolley (23), fixed pulley one (24), fixed pulley two (25), fixed
Pulley three (26) and fixed pulley four (27)；The fixed pulley one (24) and fixed pulley two (25) are relatively arranged on the non-slip mat
(21) at the marginal position at both ends, the slender U-shaped channel (22) is set to the fixed pulley one (24) and fixed pulley two (25)
Between；The slender U-shaped channel (22) is made of three pieces of glass plates, has a rectangular aperture, the slender U-shaped channel (22)
Rectangular aperture end is connect with the non-slip mat (21), and the slender U-shaped channel (22) is close to fixed pulley one (24) and far from fixed sliding
One end of one (24) of wheel is respectively formed opening；The fixed pulley three (26) is located at the slender U-shaped channel (22) close to fixed pulley one
(24) top of one end, the fixed pulley four (27) are located at the slender U-shaped channel (22) close to fixed pulley two (25) one end
Top, weight bearing trolley (23) are located at the top of the non-slip mat (21) and are connected with drawstring (28)；
Grid mechanism for testing (3) of creeping includes cushion (31) and grid is creeped test suite, and the grid is creeped test group
Part include two pieces of transparent support plates (32) and Test Network (33) lattice, two pieces of transparent support plates (32) with the glass box body
(11) bottom is vertical, and two pieces of transparent support plates (32) are in mirror settings and the bottom of lower end and the glass box body (11)
Formation is detachably connected, and the Test Network (33) is set at the medium position between two pieces of transparent support plates (32), described
The bottom of the glass box body (11) is layed in below cushion (31) Yu Suoshu Test Network (33)；
The water maze mechanism for testing (4) includes pond (41) and the half space (42) of hollow upper end opening, the pond
(41) bottom is equipped with several jacks (43), and the lower end of the half space (42) is inserted in the jack (43)；
The suspension mechanism for testing (5) includes neonychium (51) and suspension test suite, and the neonychium (51) is layed in described
The bottom of glass box body (11), the suspension test suite are set to the top of the neonychium (51)；The suspension test suite
Including two support rods (52) and wirerope (53), two support rods (52) are in mirror settings in the neonychium (51)
The lower end of two sides, two support rods (52) is connect with the bottom of the glass box body (11), the wirerope (53)
Both ends are connect with the top of two support rods (52) respectively.
2. a kind of integration aptitude tests platform for cerebral ischemia mouse according to claim 1, feature
It is: is equipped with cross partition (17) in the glass box body (11), the cross partition (17) is by the glass box body
(11) one area of equal-sized test (13), test 2nd area (14), test 3rd area (15) and test 4th area (16) are separated into；It is described
Weight bearing creeps mechanism for testing (2) in one area of the test (13), and the grid creeps mechanism for testing (3) set on the test
In 2nd area (14), the water maze mechanism for testing (4) is set in 3rd area of the test (15), and the suspension mechanism for testing (5) sets
In 4th area of the test (16).
3. a kind of integration aptitude tests platform for cerebral ischemia mouse according to claim 1, feature
Be: the weight bearing trolley (23) is made of mobile chassis (231) and car body (232), and the car body (232) is installed on the shifting
The top of dynamic chassis (231), the car body (232) are equipped with the object placing cavity (233) of upper end opening.
4. a kind of integration aptitude tests platform for cerebral ischemia mouse according to claim 3, feature
Be: the car body (232) is equipped with opening towards the dark hole (234) of the fixed pulley one (24).
5. a kind of integration aptitude tests platform for cerebral ischemia mouse according to claim 1, feature
Be: the bottom of the glass box body (11) sets that there are two the card slots that are adapted to the lower end of two pieces of transparent support plates (32)
(141), the lower end of two pieces of transparent support plates (32) is connected in corresponding card slot (141) respectively；The Test Network (33) includes
Grid frame (331) and steel wire (332), the steel wire (332) are mounted on inside the grid frame (331), and described two
The middle inside of block transparent support plate (32) is horizontally arranged with slot (321), and the both ends of the Test Network (33) plug respectively
In corresponding slot (321).
6. a kind of integration aptitude tests platform for cerebral ischemia mouse according to claim 5, feature
Be: wherein one end that the grid frame (331) exposes to the slot (321) extends outwardly, and is formed for picking up mouse
Pickup platform (333)；One of transparent support plate (32) is connected with camera shooting far from described one end for picking up platform (333) and puts down
Platform (322), the platform for video camera (322) are described soft at the medium position between the Test Network (33) and cushion (31)
The both ends of pad (31) extend to the grid frame (331) and expose to except the both ends of the slot (321) at least 15cm.
7. a kind of integration aptitude tests platform for cerebral ischemia mouse according to claim 1, feature
Be: the bottom of jack (43) pond Yu Suoshu (41) circularizes array distribution, the top etc. at pond (41) edge
Spacing is equipped with four label columns (44).
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