CN209237405U - A kind of valaciclovir hydrochlordide crystallization apparatus - Google Patents
A kind of valaciclovir hydrochlordide crystallization apparatus Download PDFInfo
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- CN209237405U CN209237405U CN201821988618.3U CN201821988618U CN209237405U CN 209237405 U CN209237405 U CN 209237405U CN 201821988618 U CN201821988618 U CN 201821988618U CN 209237405 U CN209237405 U CN 209237405U
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- crystallizing tank
- crystallization
- diversion pipe
- cooling cylinder
- stirring rod
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Abstract
The utility model provides a kind of valaciclovir hydrochlordide crystallization apparatus, including crystallizing tank, shell is equipped on the outside of crystallizing tank, shell and crystallizing tank form cooling chamber, cooling chamber upper end is equipped with the first refrigerant inlet, lower end is equipped with the first refrigerant exit, cooling cylinder is equipped in crystallizing tank, cooling cylinder and crystallization pot sidewall form crystallization cavity, crystallization cavity upper end is equipped with feeding inlet, lower end is equipped with discharge gate, box is connected and fixed by support rod at the top of crystallizing tank, fixed bin lower rotation installs diversion pipe, diversion pipe lower end is rotatably installed at the top of cooling cylinder, motor is equipped at the top of crystallizing tank, the output end of motor is equipped with driving gear, diversion pipe is equipped with the driven gear engaged with driving gear, fixed bin is equipped with the second refrigerant inlet, cooling cylinder lower end is equipped with the second refrigerant exit, diversion pipe connects stirring rod by connection frame, stirring rod is arranged in crystallization cavity, Stirring rod is equipped with stirring blade.The device can be such that material is quickly cooled down, to improve the uniformity of crystalline rate and crystallization.
Description
Technical field
The utility model belongs to valaciclovir hydrochlordide production and processing equipment, in particular to a kind of valaciclovir hydrochlordide knot
Brilliant device.
Background technique
Solution crystallization process is the process that substance is changed into crystalline state from liquid, to undergo two steps: crystallization nucleation and
Crystal growth.Crystallization nucleation is that a certain number of nucleus are generated in supersaturated solution；And crystalline substance is grown on the basis of nucleus
Body is then crystal growth.When valaciclovir hydrochlordide crystallization production, after usually material to be crystallized is put into crystallizing tank, pass through
After adding reactant in crystallizing tank, then cooling down is carried out to crystallizing tank, finally makes to form crystalline particle in crystallizing tank.
When valaciclovir hydrochlordide crystallization production, since the heat-transfer effect in crystallizing tank is uneven, close to crystallization pot sidewall
For material under the action of cooling coil, crystallization is very fast, and close to the material of crystallizing tank center due to close to cold source farther out, and
And the center in stirring, crystallization is slower, to cause crystallization uneven.And in crystallization production, due to reactant
It is mixed unevenly with material to be crystallized, causes partial material crystallization to be not thorough, influence product quality.
Summary of the invention
The technical problem to be solved by the utility model is to provide a kind of valaciclovir hydrochlordide crystallization apparatus, improve crystallization
The heat-transfer effect uniformity improves crystalline rate.
A kind of valaciclovir hydrochlordide crystallization that in order to solve the above technical problems, the technical scheme adopted by the utility model is:
Device, including crystallizing tank, the crystallizing tank outside are equipped with shell, and shell and crystallizing tank form cooling chamber, and cooling chamber upper end is equipped with
First refrigerant inlet, lower end are equipped with the first refrigerant exit, cooling cylinder are equipped with inside crystallizing tank, between cooling cylinder and crystallization pot sidewall
Crystallization cavity is formed, crystallization cavity upper end is equipped with feeding inlet, and lower end is equipped with discharge gate, is connected and fixed at the top of crystallizing tank by support rod
Box, fixed bin lower rotation install diversion pipe, and diversion pipe lower end is rotatably installed at the top of cooling cylinder, diversion pipe upper and lower ends difference
It is connected to fixed bin and cooling cylinder, motor is equipped at the top of crystallizing tank, the output end of motor is equipped with driving gear, and diversion pipe is equipped with
The driven gear engaged with driving gear, fixed bin are equipped with the second refrigerant inlet, and cooling cylinder lower end is equipped with the second refrigerant exit,
Diversion pipe connects stirring rod by connection frame, and stirring rod is arranged in crystallization cavity, and stirring rod is equipped with stirring blade.
In preferred scheme, the stirring rod lower end is equipped with scraper plate, and scraper plate bottom is equipped with hairbrush.
In preferred scheme, attachment device is equipped between the stirring rod and stirring blade, attachment device includes connecting rod
And link block, link block is equipped with the through-hole passed through for connecting rod and the sliding slot being connected to through-hole, and connecting rod one end is equipped with and cunning
The sliding block of slot cooperation, connecting rod are connect far from one end of link block with stirring rod, link block one end and stirring far from connecting rod
Blade connects, pocketed springs in connecting rod.
In preferred scheme, the splicing groove of annular is equipped on the upside of the connection frame, splicing groove is arranged below feeding inlet, connects
Hopper bottom is equipped with material spilling hole.
In preferred scheme, the cooling chamber sets gradually multilayer insulating panel from top to bottom, and partition is equipped with scupper, adjacent
Scupper on partition is staggered.
A kind of valaciclovir hydrochlordide crystallization apparatus provided by the utility model, crystallizing tank is isolated by the cooling cylinder of setting
Columnar crystallization cavity is circularized, coolant liquid circulates in cooling chamber and cooling cylinder, thus the inner side and outer side of crystallization cavity
Effective heat transfer can be carried out, then by the stirring action of stirring blade, material to be crystallized can be made to be quickly cooled down, thus
Improve the uniformity of crystalline rate and crystallization.
Detailed description of the invention
The utility model is described in further detail with reference to the accompanying drawings and examples:
Fig. 1 is the overall structure diagram of the utility model.
Fig. 2 is the scheme of installation of stirring blade.
In figure: crystallizing tank 1, shell 2, cooling chamber 3, the first refrigerant inlet 4, the first refrigerant exit 5, cooling cylinder 6, crystallization cavity
7, feeding inlet 8, discharge gate 9, support rod 10, fixed bin 11, diversion pipe 12, motor 13, driving gear 14, driven gear 15, the
Two refrigerant inlets 16, the second refrigerant exit 17, connection frame 18, stirring rod 19, stirring blade 20, scraper plate 21, hairbrush 22, connecting rod
23, link block 24, through-hole 25, sliding slot 26, sliding block 27, spring 28, splicing groove 29, partition 30, scupper 31.
Specific embodiment
As shown in Figure 1, a kind of valaciclovir hydrochlordide crystallization apparatus, including crystallizing tank 1, it is equipped on the outside of the crystallizing tank 1 outer
Shell 2, shell 2 and crystallizing tank 1 form cooling chamber 3, and 3 upper end of cooling chamber is equipped with the first refrigerant inlet 4, and lower end is equipped with the first refrigerant and goes out
Mouth 5, the first refrigerant exit 5 are equipped with valve, and cooling cylinder 6 is equipped with inside crystallizing tank 1, and cooling cylinder 6 and crystallizing tank 1 are coaxially disposed,
6 upper end of cooling cylinder seals, and crystallization cavity 7 is formed between 1 side wall of cooling cylinder 6 and crystallizing tank, and 7 upper end of crystallization cavity is equipped with feeding inlet 8, under
End is equipped with discharge gate 9, passes through support rod 10 at the top of crystallizing tank 1 and is connected and fixed box 11,11 bottom of fixed bin passes through bearing and rotates peace
Diversion pipe 12 is filled, 12 lower end of diversion pipe is rotatably installed in 6 top of cooling cylinder by bearing, and crystallizing tank 1 is arranged in diversion pipe 12
On center line, 12 upper and lower ends of diversion pipe are connected to fixed bin 11 and cooling cylinder 6 respectively, and motor 13, electricity are equipped at the top of crystallizing tank 1
The output end of machine 13 is equipped with driving gear 14, and diversion pipe 12 is equipped with the driven gear 15 engaged with driving gear 14, fixed bin 1
It is equipped with the second refrigerant inlet 16,6 lower end of cooling cylinder is equipped with the second refrigerant exit 17, and the second refrigerant exit 17 is equipped with valve,
Diversion pipe 12 connects stirring rod 19 by connection frame 18, and stirring rod 19 is arranged in crystallization cavity 7, and stirring rod 19 is equipped with paddle
Piece 20.
Crystallization cavity 7 is the cavity of circular cylindrical, and coolant liquid circulates in cooling chamber 3 and cooling cylinder 6, to crystallize
The inner side and outer side of chamber 7 can carry out effective heat transfer, then pass through the stirring action of stirring blade 20, can make to be crystallized
Material is quickly cooled down, to improve the uniformity of crystalline rate and crystallization.
In the present embodiment, coolant liquid is chilled water or chilled brine.
19 lower end of stirring rod is equipped with scraper plate 21, and 21 bottom of scraper plate is equipped with hairbrush 22.The Flow of Goods and Materials of 7 bottom of crystallization cavity
Property it is smaller, the material of 7 bottom of crystallization cavity is stirred by scraper plate 21 and hairbrush 22, be conducive to crystallization uniformity；Together
When by the cleaning of hairbrush 22, be conducive to crystallized product and be discharged from discharge gate 9, improve the recycling of crystallization.
Preferably, as shown in Fig. 2, being equipped with attachment device, attachment device packet between the stirring rod 19 and stirring blade 20
Connecting rod 23 and link block 24 are included, link block 24 is equipped with the through-hole 25 passed through for connecting rod 23 and the sliding slot being connected to through-hole 25
26,23 one end of connecting rod is equipped with the sliding block 27 cooperated with sliding slot 26, the one end of connecting rod 23 far from link block 24 and stirring rod 19
Connection, the one end of link block 24 far from connecting rod 23 are connect with stirring blade 20, stirring blade 20 and 6 outer wall of cooling cylinder or crystallization
1 inner wall of tank is close to setting, pocketed springs 28 in connecting rod 23.
By the elastic compression power of spring 28, link block 24 and stirring blade 20 is made to be pressed on 6 outer wall of cooling cylinder or knot
Brilliant 1 inner wall of tank, thus make stirring rod 23 along diversion pipe 12 rotate during, stirring blade 20 is not only stirred material,
Stirring blade 20 also strikes off the crystallization of 1 inner wall of 6 outer wall of cooling cylinder or crystallizing tank, due to 6 outer wall of cooling cylinder or crystallizing tank 1
The temperature of inner wall is lower, is easy crystallization, and stirring blade 20 strikes off, and prevents 1 inner wall crystal grain of 6 outer wall of cooling cylinder or crystallizing tank
It is excessive, and cause crystallization uneven.
The splicing groove 29 of annular is equipped on the upside of the connection frame 18, splicing groove 29 is arranged below feeding inlet 8, splicing groove 29
Bottom is equipped with material spilling hole.
Reactant is after the addition of feeding inlet 8, since connection frame 18 is rotated with diversion pipe 12, so that splicing groove 29 is rotated,
It falls into reactant uniformly in crystallization cavity 7, facilitates the uniformity of crystallization.
The cooling chamber 3 sets gradually multilayer insulating panel 30 from top to bottom, and partition 30 is equipped with scupper 31, adjacent separator 30
On scupper 31 be staggered.
By setting partition 30 and the scupper 21 being staggered, coolant liquid flow channel length in cooling chamber 3 is improved, is increased
Add the residence time of coolant liquid, to improve cooling efficiency, reduces the waste of coolant liquid.
Specific use process is as follows for the utility model, and valaciclovir hydrochlordide is added from feeding inlet 8 to crystallization cavity 7 first
In, make to open motor 13 in coolant liquid filling cooling chamber 3 and cooling cylinder 6, reactant is added from feeding inlet 8, makes coolant liquid
It is circulated in cooling chamber 3 and cooling cylinder 6, after the completion of crystallization, opens the valve on discharge gate 9, crystallized product is from discharge
Mouth 9 is discharged.
The above embodiments are only the optimal technical scheme of the utility model, and are not construed as the limit for the utility model
System, the technical solution that the protection scope of the utility model should be recorded with claim, the technical solution recorded including claim
The equivalents of middle technical characteristic are protection scope.Equivalent replacement i.e. within this range is improved, also in the utility model
Protection scope within.
Claims (5)
1. a kind of valaciclovir hydrochlordide crystallization apparatus, including crystallizing tank (1), it is characterised in that: be equipped on the outside of the crystallizing tank (1)
Shell (2), shell (2) and crystallizing tank (1) composition cooling chamber (3), cooling chamber (3) upper end are equipped with the first refrigerant inlet (4), lower end
Equipped with the first refrigerant exit (5), cooling cylinder (6) are equipped with inside crystallizing tank (1), shape between cooling cylinder (6) and crystallizing tank (1) side wall
At crystallization cavity (7), crystallization cavity (7) upper end is equipped with feeding inlet (8), and lower end is equipped with discharge gate (9), passes through branch at the top of crystallizing tank (1)
Strut (10) is connected and fixed box (11), and fixed bin (11) lower rotation installs diversion pipe (12), diversion pipe (12) lower end rotation peace
At the top of cooling cylinder (6), diversion pipe (12) upper and lower ends are connected to fixed bin (11) and cooling cylinder (6) respectively, crystallizing tank (1)
Top is equipped with motor (13), and the output end of motor (13) is equipped with driving gear (14), and diversion pipe (12) is equipped with and driving gear
(14) driven gear (15) engaged, fixed bin (11) are equipped with the second refrigerant inlet (16), and cooling cylinder (6) lower end is equipped with second
Refrigerant exit (17), diversion pipe (12) are arranged by connection frame (18) connection stirring rod (19), stirring rod (19) in crystallization cavity (7)
Interior, stirring rod (19) is equipped with stirring blade (20).
2. a kind of valaciclovir hydrochlordide crystallization apparatus according to claim 1, it is characterised in that: under the stirring rod (19)
End is equipped with scraper plate (21), and scraper plate (21) bottom is equipped with hairbrush (22).
3. a kind of valaciclovir hydrochlordide crystallization apparatus according to claim 1, it is characterised in that: the stirring rod (19) and
Attachment device is equipped between stirring blade (20), attachment device includes connecting rod (23) and link block (24), and link block (24) is set
Have the through-hole (25) passed through for connecting rod (23) and a sliding slot (26) being connected to through-hole (25), connecting rod (23) one end be equipped with
The sliding block (27) of sliding slot (26) cooperation, connecting rod (23) are connect far from the one end of link block (24) with stirring rod (19), link block
(24) one end far from connecting rod (23) is connect with stirring blade (20), pocketed springs (28) in connecting rod (23).
4. a kind of valaciclovir hydrochlordide crystallization apparatus according to claim 1, it is characterised in that: on the connection frame (18)
Side is equipped with the splicing groove (29) of annular, and below feeding inlet (8), splicing groove (29) bottom is equipped with material leakage for splicing groove (29) setting
Hole.
5. a kind of valaciclovir hydrochlordide crystallization apparatus according to claim 1, it is characterised in that: the cooling chamber (3) from
It is set gradually under multilayer insulating panel (30), partition (30) is equipped with scupper (31), the scupper in adjacent separator (30)
(31) it is staggered.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821988618.3U CN209237405U (en) | 2018-11-29 | 2018-11-29 | A kind of valaciclovir hydrochlordide crystallization apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821988618.3U CN209237405U (en) | 2018-11-29 | 2018-11-29 | A kind of valaciclovir hydrochlordide crystallization apparatus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209237405U true CN209237405U (en) | 2019-08-13 |
Family
ID=67529336
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821988618.3U Active CN209237405U (en) | 2018-11-29 | 2018-11-29 | A kind of valaciclovir hydrochlordide crystallization apparatus |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN209237405U (en) |
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2018
- 2018-11-29 CN CN201821988618.3U patent/CN209237405U/en active Active
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