CN209173132U - A Nasal Mucosal Atomization Drug Delivery Device Applicable to Nano Vaccination - Google Patents

Abstract

The utility model provides a nasal mucous membrane atomization drug delivery device which can be used for vaccination, which is characterized in that it includes a drug delivery atomization nozzle and a liquid storage tube body; wherein the liquid storage tube body has a mechanism for extracting liquid and pressing out liquid. Structure; the drug delivery atomizing nozzle includes a nozzle body, a seal and an atomizing component; the beginning of the nozzle body is a conical structure, the top has a spray hole, and a hollow cavity is provided inside, and the end is detachably installed in the liquid storage On the pipe body; the sealing element is sleeved on the conical structure; the atomization assembly includes a first dispersion layer, a second dispersion layer and an atomization injection layer arranged in sequence; the atomization injection layer is installed on the injection hole. The device can realize a finer atomization effect of the medicinal liquid.

Description

A Nasal Mucosal Atomization Drug Delivery Device Applicable to Nano Vaccination

technical field

The utility model relates to the field of medical experiment equipment, in particular to a nasal mucous membrane atomization drug delivery device which can be used for vaccination.

Background technique

Most infections caused by viruses and bacteria occur on mucosal surfaces such as the gastrointestinal tract, respiratory tract, and reproductive tract. Traditional vaccine injections are often administered through subcutaneous injections. Although they can produce a strong systemic immune response, they have no effect on mucosal infections. Protective effects. To be effective in preventing mucosal infections, vaccines are most effective when stimulating the immune system via the mucosal route. The nasal mucosa is an important part of the mucosal immune system, and nasal mucosal immunization is an attractive approach. However, the existing equipment dedicated to nasal mucosal injection is scarce, and the existing injection system is often used after simple modification. It often has the problem of poor atomization level and the problem of injected drug flowing in streams, resulting in extremely uncomfortable injection. Poor, the result of poor injection effects.

In addition, for children, the traditional injection vaccine injection method is often a process full of fear, and it is inevitable that they will struggle violently during the injection process, which leads to difficulties for doctors to inject and prolonged pain for children, which is inevitable. There are also some medical conflicts and injuries that often occur. Therefore, a novel injection method and injection tool for immunization vaccines are in urgent need.

In addition, for biological experiments that require atomized drug administration, the above-mentioned modified atomized syringes for human body are often used now. However, on the one hand, because the specifications of this type of syringe are suitable for human beings, the effect of atomization For small experimental animals, it is not applicable, therefore, in the existing experiments, it is often impossible to achieve a good effect of aerosol administration.

Secondly, because animals often do not cooperate during the experiment, special clamps or equipment are often used in the process of drug administration. However, there is no corresponding fixed device for drug administration to the nasal mucosa. Therefore, for some new trainees or experimenters, when administering drugs to the nasal mucosa of animals such as mice, it is often difficult to control the stability of the administered dose due to the strong struggle of the animals, resulting in inaccurate experimental data.

Utility model content

The utility model aims to overcome the above-mentioned defects, and provides a nasal mucous membrane atomization drug delivery device with simple operation and good atomization effect, which can be used for nano-vaccination, and the device can be used for ultra-fine nasal atomization drug delivery , especially suitable for children's drug administration. In addition, the nebulizer can also effectively atomize the nasal mucosa of experimental animals.

The utility model provides a nasal mucosal atomization drug delivery device that can be used for nano-vaccination, which is characterized in that it includes a drug delivery atomization nozzle and a liquid storage tube;

In the utility model, the drug delivery atomizing nozzle can achieve a good atomization effect through its specific structural design; the liquid storage tube is used to store the drug liquid to be given, and is generally a cylindrical structure. The push rod inside is used to realize the extraction and injection of liquid.

Wherein, the above-mentioned liquid storage tube body has a structure for extracting liquid and extruding liquid; such as: a syringe structure, that is, a structure including a syringe and a push rod, and the push rod is arranged in the syringe to form negative pressure. The extraction of the liquid is realized, and when the extraction needs to be administered, the liquid is pressed out by pushing.

The above-mentioned drug delivery atomizing nozzle includes a nozzle body, a seal and an atomizing assembly;

The starting end of the above-mentioned nozzle body is a conical structure, the top has a spray hole, and a hollow cavity is provided inside, and the end of the nozzle is detachably installed in the liquid storage tube; and there is a matching structure inside.

The above-mentioned sealing element is sleeved on the tapered structure; it is generally made of medical rubber.

The above-mentioned atomization assembly includes a first distribution layer, a second distribution layer and an atomization injection layer arranged in sequence;

The above-mentioned atomized spray layer is installed on the spray hole.

Further, the present invention provides a nasal mucosal atomization drug delivery device that can be used for nano-vaccination, and also has the following characteristics: that is, the pore size of the first dispersion layer is larger than that of the second dispersion layer;

The pore diameter of the above-mentioned second dispersion layer is larger than that of the atomized injection layer.

Further, the present invention provides a nasal mucosal atomization drug delivery device that can be used for nano-vaccination, and also has the following characteristics: that is, the above-mentioned atomization component also includes an intermediate dispersion column;

The above-mentioned intermediate dispersion column penetrates the first dispersion layer and ends between the second dispersion layer and the first dispersion layer;

Capillary pores are uniformly distributed on the above-mentioned intermediate dispersion column.

Furthermore, the present invention provides a nasal mucosa atomization drug delivery device that can be used for nano-vaccination, which also has the feature that a torsion handle is provided on the outer surface of the end of the nozzle body.

Furthermore, the nasal mucous membrane atomization drug delivery device provided by the present invention, which can be used for vaccination, also has the following characteristics: that is, the end of the above-mentioned nozzle body also has an external thread structure;

One end of the above-mentioned liquid storage pipe body is provided with an internal thread structure;

The above-mentioned internal thread structure matches the external thread structure.

Furthermore, the nasal mucosa atomization drug delivery device for nano-vaccination provided by the present invention also has the feature that a clamping device is provided on the outer surface of the above-mentioned liquid storage tube.

Further, the present invention provides a nasal mucosal aerosol drug delivery device that can be used for nano-vaccination, and also has the following characteristics: that is, the above-mentioned clamping device is a pair that can rotate on the outer surface of the liquid storage tube and/or Or an elastic rod with adjustable length;

The end of the elastic rod has a clamping piece.

Further, a nasal mucosa atomization drug delivery device that can be used for nano-vaccination provided by the present invention also has the following characteristics: that is, the above-mentioned liquid storage tube body is a double-layer structure composed of an inner tube body and an outer tube body ;

The clamping device is installed on the outer surface of the outer tube body. Thereby play a leak-proof effect.

Further, a nasal mucosa atomization drug delivery device that can be used for nano-vaccination provided by the present invention also has the following characteristics: that is, the inner surface of the above-mentioned liquid storage tube is provided with several obliquely arranged elastic limiters. bit pieces. So as to achieve the effect of precise drug delivery.

Further, the present invention provides a nasal mucosa atomization drug delivery device that can be used for nano-vaccination, which also has the following characteristics: that is, it also includes an injection head;

The injection head is detachably mounted on the end of the liquid storage tube. Therefore, the absorption of the medicine can be realized by changing the state of the injection head.

Function and effect of the present utility model:

The utility model adopts the structure of the multi-layer dispersing plate to realize the effect of continuously crushing the propelled medicine, thereby effectively improving the atomization effect of the liquid. At the same time, as an optimal solution, the structure of the middle dispersion column is also set, so as to further improve the atomization effect, avoid the problem of dripping drug leakage in traditional equipment, and realize the ultra-fine spraying of the nose of adults and children medication.

In addition, in order to realize the fixation of the head of the experimental small animal, so as to facilitate the effect of drug administration, a clamping device is added in the utility model, which can be attached to the tube wall during the non-use process without affecting the operation. In the state of use, after clamping it on both sides of the animal's head, the drug cartridge is rotated for administration. Or directly realize the fixation of the head by rotating the clamping structure.

From the perspective of the above scheme, the device of the present invention is simple to operate, and can be used for the spray administration of experimental mice and other animals to achieve a finer atomization effect of the medicinal liquid.

Description of drawings

Accompanying drawing 1, the structure schematic diagram of the nasal mucous membrane aerosol administration device that can be used for vaccination related to the first embodiment.

Accompanying drawing 2, the structural schematic diagram of the nasal mucous membrane aerosol drug delivery device that can be used for vaccination related to the second embodiment.

Accompanying drawing 3, the structure schematic diagram of the administration atomization nozzle of the nasal mucous membrane atomization administration device that can be used for vaccination related to the third embodiment.

Accompanying drawing 4 is a schematic diagram of the structure of the needle replacement head of the nasal mucous membrane atomization drug delivery device that can be used for vaccination related to Embodiments 1 to 3.

Detailed ways

Embodiment one,

As shown in Figure 1, the first embodiment provides a nasal mucosa atomization drug delivery device that can be used for nano-vaccination, which is suitable for nasal mucosa atomization drug delivery for experimental animals, including a drug delivery atomization nozzle 100 and liquid storage tube 200;

The liquid storage pipe body 200 is composed of an internal thread pipe 210, a liquid suction pipe 220 and a push-pull rod 230;

Wherein, the internally threaded pipe 210 is arranged at the end of the pumping pipe 220, and a middle pipe 211 is arranged therein;

The pumping tube 220 is hollow, and the middle tube 211 communicates with the pumping tube 220;

The push-pull rod 230 is arranged inside the liquid suction tube 220, and can move in the hollow tube body as shown by the arrow, so as to realize the suction and push out of the liquid.

The drug spray nozzle 100 is composed of a nozzle body, a seal 114 and an atomization assembly;

Wherein, the interior of the nozzle body is a hollow cavity, including a starting end 110, a middle section 120 and an end 122;

The starting end 110 of the nozzle body 100 is a conical structure, and the sealing member 114 is hospital elastic rubber, which is sleeved outside the conical structure. During the administration process, the sealing member can be inserted into the administration site. To prevent the atomized drug from flying out of the administration site. It has spray holes at the top.

The end of the nozzle body 100 is an external thread structure, and the external thread structure matches the structure of the internal thread pipe 220 , and the mutual combination and disassembly of the two parts can be realized by mutual tightening.

The structure and size of the middle tube 211 are compatible with the middle section 120 . After the two structures are installed, the middle tube 211 extends into the middle section 120 to press the liquid into the cavity of the starting end 110 .

The first dispersing plate 111, the second dispersing plate 112 and the end dispersing plate 113 are sequentially provided in the starting end 110; the three plates are provided with holes of different sizes, and the liquid is dispersed through the holes;

The aperture of the first dispersing plate 111 is larger than the aperture of the second dispersing plate 112, and the aperture of the second dispersing plate 112 is larger than the aperture of the end dispersing plate 113, so that when the medicine in the liquid storage tube 200 is pressed into the middle tube 120 , the liquid needs to be dispersed layer by layer through the first dispersing plate 111, the second dispersing plate 112 and the end dispersing plate 113, so that the droplets of macromolecules are continuously reduced until the liquid released from the end dispersing plate 113 is a mist shape.

A handle 121 is also provided on the outer surface of the middle section 120, which can facilitate the disassembly and assembly of the nozzle and the barrel.

Embodiment two,

As shown in Figure 2, this embodiment 2 provides a nasal mucosa atomization drug delivery device that can be used for nano-vaccination, which is suitable for nasal mucosa atomization drug delivery for experimental animals, including a drug delivery atomization nozzle 100 and liquid storage tube 200;

The liquid storage pipe body 200 is composed of an internal thread pipe 210, a liquid suction pipe 220 and a push-pull rod 230;

Wherein, the internally threaded pipe 210 is arranged at the end of the pumping pipe 220, and a middle pipe 211 is arranged therein;

The pumping tube 220 is hollow, and the middle tube 211 communicates with the pumping tube 220;

The push-pull rod 230 is arranged inside the liquid suction tube 220, and can move in the hollow tube body as shown by the arrow, so as to realize the suction and push out of the liquid.

Two clamping mechanisms are arranged on both sides of the outside of the suction tube 220;

The clamping structure is composed of a base 221, a rotating shaft 222, an elastic rod body 223 and an end clamping plate 224;

The base 221 is fixed on the outer tube wall of the pumping tube 220, and the rotating shaft 222 is rotatably installed in the center of the base 221, and can rotate with the arrow as shown in the figure. The elastic rod body 223 is made of elastic material , stretching adjustment can be carried out within a certain width range, and it is installed on the end of the rotating shaft 222, so that it can rotate along the outer tube wall of the suction pipe along with the rotating shaft 222. A clamping plate 224 is installed at the end of the elastic rod body 223. The clamping plate 224 has a larger surface area than the elastic rod body and can clamp the face or neck of a small animal.

In the process of use, the clamping mechanism can be rotated to the position shown in the figure, and the two clamping plates 224 are clamped on the face of the experimental animal to inject the medicine.

Alternatively, after the clamping mechanism is clamped on the face of the experimental animal from any angle, the effect of targeted administration can be achieved by rotating the angle of the entire nozzle and cylinder.

The rod body generally has a structure with adjustable length, so that different dosing schemes for different animals can be realized.

The drug spray nozzle 100 is composed of a nozzle body, a seal 114 and an atomization assembly;

Wherein, the interior of the nozzle body is a hollow cavity, including a starting end 110, a middle section 120 and an end 122;

The starting end 110 of the nozzle body 100 is a conical structure, and the sealing member 114 is hospital elastic rubber, which is sleeved outside the conical structure. During the administration process, the sealing member can be inserted into the administration site. To prevent the atomized drug from flying out of the administration site. It has spray holes at the top.

The end of the nozzle body 100 is an external thread structure, and the external thread structure matches the structure of the internal thread pipe 220 , and the mutual combination and disassembly of the two parts can be realized by mutual tightening.

The structure and size of the middle tube 211 are compatible with the middle section 120 . After the two structures are installed, the middle tube 211 extends into the middle section 120 to press the liquid into the cavity of the starting end 110 .

The first dispersing plate 111, the second dispersing plate 112 and the end dispersing plate 113 are sequentially provided in the starting end 110; the three plates are provided with holes of different sizes, and the liquid is dispersed through the holes;

The aperture of the first dispersing plate 111 is larger than the aperture of the second dispersing plate 112, and the aperture of the second dispersing plate 112 is larger than the aperture of the end dispersing plate 113, so that when the medicine in the liquid storage tube 200 is pressed into the middle tube 120 , the liquid needs to be dispersed layer by layer through the first dispersing plate 111, the second dispersing plate 112 and the end dispersing plate 113, so that the droplets of macromolecules are continuously reduced until the liquid released from the end dispersing plate 113 is a mist shape.

A handle 121 is also provided on the outer surface of the middle section 120, which can facilitate the disassembly and assembly of the nozzle and the barrel.

Embodiment three,

As shown in FIG. 3 , in this solution, the drug delivery atomizing nozzle 100 is improved.

The drug spray nozzle 100 is composed of a nozzle body, a seal 114 and an atomization assembly;

Wherein, the interior of the nozzle body is a hollow cavity, including a starting end 110, a middle section 120 and an end 122;

The starting end 110 of the nozzle body 100 is a conical structure, and the sealing member 114 is hospital elastic rubber, which is sleeved outside the conical structure. During the administration process, the sealing member can be inserted into the administration site. To prevent the atomized drug from flying out of the administration site. It has spray holes at the top.

The end 122 of the nozzle body 100 is an external thread structure, and the external thread structure matches the structure of the internal thread pipe 220 in the first and second embodiments above. Combine and dismantle.

The middle section 120 includes a middle-front section and a middle-back section. The structure and size of the middle-back section match the middle pipe 211 in Embodiments 1 and 2. After the two structures are installed, the middle pipe 211 extends into the middle section 120 , so that the liquid can be pressed into the cavity of the starting end 110 .

A trapezoidal guide ring 123 is provided in the middle and front section, and the trapezoidal guide ring 123 makes the liquid flow path during entry smaller, thereby giving greater hydraulic pressure;

The liquid outlet end of the guide ring 123 is connected with an intermediate dispersing cylinder 115, which is covered with capillary holes. The dispersion plate or the second dispersion plate, thereby improving the efficiency and quality of liquid atomization. The pore diameter of the capillary hole may be between the pore diameters of the first dispersion plate 111 and the second dispersion plate 112 .

The first dispersing plate 111, the second dispersing plate 112 and the end dispersing plate 113 are sequentially arranged in the starting end 110; the three plates are provided with holes of different sizes, through which the liquid dispersed by the middle dispersing cylinder 115 passes through. The function of the hole is broken up again;

The aperture of the first dispersing plate 111 is larger than the aperture of the second dispersing plate 112, and the aperture of the second dispersing plate 112 is larger than the aperture of the end dispersing plate 113, so that when the medicine in the liquid storage tube 200 is pressed into the middle tube 120 , the liquid needs to be dispersed layer by layer through the first dispersing plate 111, the second dispersing plate 112 and the end dispersing plate 113, so that the droplets of macromolecules are continuously reduced until the liquid released from the end dispersing plate 113 is a mist shape.

A handle 121 is also provided on the outer surface of the middle section 120, which can facilitate the disassembly and assembly of the nozzle and the barrel.

As shown in Figure 4, it is a replacement needle matching the above three embodiments, which is composed of a needle 320 and a nozzle body 310;

The inside of the nozzle body 310 is a hollow structure;

Its top is equipped with a needle, which can be used to draw medicine;

The bottom end is provided with an external thread base 312, which can be matched with the cylinder body;

Its outer wall is equipped with a handle 311, which can be convenient for installation and disassembly.

In addition, the liquid suction pipe 220 may also be provided with several sloping plates arranged in the direction of pulling out the liquid, and the sloping plates are made of elastic medical rubber.

After the liquid is extracted quantitatively, due to the blocking effect of the inclined plate, the push rod is not easy to slide down to the liquid ejection end under the action of gravity, which avoids the problem of inaccurate dosage caused by drug omission.

Claims (10)

1. A nasal mucosa atomization drug delivery device that can be used for nano-vaccination, characterized in that: it includes a drug delivery atomization nozzle and a liquid storage tube; Wherein, the liquid storage pipe body has a structure for extracting liquid and pressing out liquid; The drug delivery atomizing nozzle includes a nozzle body, a seal and an atomizing assembly; The beginning of the nozzle body is a conical structure, the top has a spray hole, and a hollow cavity is provided inside, and the end of the nozzle is detachably installed in the liquid storage tube; The sealing element is sleeved on the tapered structure; The atomization assembly includes a first distribution layer, a second distribution layer and an atomization injection layer arranged in sequence; The atomized spray layer is installed on the spray hole. 2. A kind of nasal mucosal atomization drug delivery device that can be used for nano vaccine vaccination as claimed in claim 1, characterized in that: The pore size of the first distribution layer is larger than that of the second distribution layer; The pore diameter of the second distribution layer is larger than that of the atomized injection layer. 3. a kind of nasal mucosa atomization drug delivery device that can be used for nano-vaccination as claimed in claim 1, is characterized in that: The atomization assembly also includes an intermediate dispersion column; The middle dispersing column penetrates the first dispersing layer and ends between the second dispersing layer and the first dispersing layer; Capillary holes are uniformly distributed on the middle dispersion column. 4. a kind of nasal mucosal atomization drug delivery device that can be used for nano-vaccination as claimed in claim 1, is characterized in that: A torque handle is also provided on the outer surface of the end of the nozzle body. 5. A kind of nasal mucosa atomization drug delivery device that can be used for nano vaccine vaccination as claimed in claim 1, characterized in that: The end of the nozzle body also has an external thread structure; One end of the liquid storage pipe body is provided with an internal thread structure; The internal thread structure matches the external thread structure. 6. A kind of nasal mucosal atomization drug delivery device that can be used for nano-vaccination as claimed in claim 1, characterized in that: A clamping device is also provided on the outer surface of the liquid storage tube. 7. A kind of nasal mucosa atomization drug delivery device that can be used for nano vaccine vaccination as claimed in claim 6, characterized in that: The clamping device is a pair of elastic rods that can rotate on the outer surface of the liquid storage tube and/or can adjust the length; The end of the elastic rod has a clamping piece. 8. A kind of nasal mucosal atomization drug delivery device that can be used for nano-vaccination as claimed in claim 6, characterized in that: The liquid storage tube is a double-layer structure composed of an inner tube and an outer tube; The clamping device is installed on the outer surface of the outer tubular body. 9. A kind of nasal mucosal atomization drug delivery device that can be used for nano-vaccination as claimed in claim 1, characterized in that: The inner surface of the liquid storage pipe body is provided with several obliquely arranged elastic stoppers. 10. A nasal mucosa atomization delivery device that can be used for nano-vaccination as described in any one of claims 1-9, characterized in that: Injection head is also included; The injection head is detachably installed on the end of the liquid storage tube.