CN209173132U - A kind of schneiderian membrance atomized medicine introducing device can be used for nano vaccine inoculation - Google Patents

A kind of schneiderian membrance atomized medicine introducing device can be used for nano vaccine inoculation Download PDF

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Publication number
CN209173132U
CN209173132U CN201821184835.7U CN201821184835U CN209173132U CN 209173132 U CN209173132 U CN 209173132U CN 201821184835 U CN201821184835 U CN 201821184835U CN 209173132 U CN209173132 U CN 209173132U
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tube body
vaccine inoculation
introducing device
medicine introducing
schneiderian membrance
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何斌
石学银
吴广喜
陈依君
薛晓梅
洪婷
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XinHua Hospital Affiliated To Shanghai JiaoTong University School of Medicine
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XinHua Hospital Affiliated To Shanghai JiaoTong University School of Medicine
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Abstract

The utility model provides a kind of schneiderian membrance atomized medicine introducing device that can be used for vaccine inoculation, it is characterised in that: including administration atomizer and liquid accommodating tube body;Wherein, liquid accommodating tube body has the structure for extracting liquid and extruding liquid;It includes nozzle body, sealing element and atomizing component that atomizer, which is administered,;The beginning of nozzle body is pyramidal structure, and top has spray-hole, is internally provided with hollow cavity, end is mounted on liquid accommodating tube body;Sealing element is sheathed at pyramidal structure;Atomizing component includes the first dispersion layer, the second dispersion layer and atomized spray layer set gradually;Atomized spray layer is installed on spray-hole.The device can be realized the more tiny atomizing effect of medical fluid.

Description

A kind of schneiderian membrance atomized medicine introducing device can be used for nano vaccine inoculation
Technical field
The utility model relates to medical experiment apparatus fields, and in particular, to a kind of schneiderian membrance that can be used for vaccine inoculation Atomized medicine introducing device.
Background technique
Infection caused by most of virus, bacterium occurs in mucomembranous surfaces such as gastrointestinal tract, respiratory tract and genital tracts, traditional Vaccine injection is immune, carries out often through subcutaneous injection, although can produce stronger systemic immunity reaction, to mucous membrane sense Contaminate unprotect effect.So that effectively prevent mucosal infections, vaccine needs transmucosal route stimulation immune system maximally efficient.And Schneiderian membrane is the pith of mucomembranous immune system, and nasal mucosal immune is a kind of very attractive approach.Then, existing special It is rare for schneiderian membrane injection device, simple refit often is carried out to existing injecting systems and was carried out later using often depositing The problem of horizontal bad in atomization, and injection drug enters at plume, cause its injection body-sensing very poor, the undesirable knot of injection effect Fruit.
In addition, for for children, the injecting method of the vaccine of traditional injection, an often terrified process, It inevitably during injection, acutely struggles, also has led to the extension of the difficulty and children's pain of doctor's injection, unavoidably Also tend to some contradictions and injury medically occur.So injecting method and the injection of a kind of novel immune vaccine Tool is extremely badly in need of.
In addition, for the Bioexperiment for needing atomized medicine introducing, now often using the mist applied to human body after above-mentioned repacking Change syringe to carry out, still, on the one hand such syringe is suitable for the mankind due to specification, so the effect of its atomization, for figure compared with For small experimental animal, and it is not suitable for, so, good atomized medicine introducing effect is often unable to reach in existing experiment.
Secondly as animal is during the experiment, often and mismatch, so, during administration, often to use Dedicated fixture or equipment carry out, still, for schneiderian membrance position administration but without corresponding fixed equipment, so, it is right For some new students or laboratory technician, when the schneiderian membrance administration of the animals such as mouse, often due to the struggle of animal is strong, cause to The stability of pharmaceutical quantities is difficult to control, so as to cause the problem of the inaccuracy of experimental data.
Utility model content
The utility model is intended to overcome drawbacks described above, provides a kind of easy to operate, and the good one kind of atomizing effect can be used for receiving The schneiderian membrance atomized medicine introducing device of rice vaccine inoculation, which can be used for the nose atomized medicine introducing of fine, particularly suitable for youngster Child's administration, in addition, the atomizer can also effectively be directed to the schneiderian membrance atomized medicine introducing of experimental animal.
A kind of schneiderian membrance atomized medicine introducing device can be used for nano vaccine inoculation provided by the utility model, feature exist In: including administration atomizer and liquid accommodating tube body;
In the present invention, which can be realized good atomization effect by its specific structure design Fruit;The liquid accommodating tube body passes through setting pushing away in the inner for storing medical fluids to be given, generally tubular structure Bar, the extraction and injection of Lai Shixian liquid.
Wherein, aforesaid liquid storage tube body has the structure for extracting liquid and extruding liquid;Such as: that is, syringe cylinder structure, includes The structure of syringe and push rod, the push rod are set in syringe, and the extraction of liquid is realized by way of forming negative pressure, works as completion When extraction needs to be administered, liquid is extruded by way of pushing.
Above-mentioned administration atomizer includes nozzle body, sealing element and atomizing component;
The beginning of said nozzle ontology is pyramidal structure, and top has spray-hole, is internally provided with hollow cavity, end End is mounted in liquid accommodating tube body;And there is the structure matched in it.
Above-mentioned sealing element is sheathed at pyramidal structure;The generally material of medical grade rubber.
Above-mentioned atomizing component includes the first dispersion layer, the second dispersion layer and atomized spray layer set gradually;
Above-mentioned atomized spray layer is installed on spray-hole.
Further, a kind of schneiderian membrance atomized medicine introducing device can be used for nano vaccine inoculation provided by the invention, also has Have the particular feature that i.e., the aperture of above-mentioned first dispersion layer be greater than the second dispersion layer;
The aperture of above-mentioned second dispersion layer is greater than atomized spray layer.
Further, a kind of schneiderian membrance atomized medicine introducing device can be used for nano vaccine inoculation provided by the invention, also has Have the particular feature that i.e., above-mentioned atomizing component further include intermediate dispersion column;
Above-mentioned intermediate dispersion column penetrates through the first dispersion layer, terminates between the second dispersion layer and the first dispersion layer;
Pore is evenly equipped in above-mentioned intermediate dispersion column.
Further, a kind of schneiderian membrance atomized medicine introducing device can be used for nano vaccine inoculation provided by the invention, also has Have the particular feature that i.e., twisting resistance handle is additionally provided on the outer surface of said nozzle body tip.
Further, a kind of schneiderian membrance atomized medicine introducing device can be used for vaccine inoculation provided by the invention also has this The characteristics of sample: i.e., the end of said nozzle ontology also there is external thread structure;
The one end that aforesaid liquid stores tube body is equipped with internal thread structure;
Above-mentioned internal thread structure matches with external thread structure.
Further, a kind of schneiderian membrance atomized medicine introducing device can be used for nano vaccine inoculation provided by the invention, also has Have the particular feature that i.e., aforesaid liquid storage tube body outer surface on be additionally provided with clamping device.
Further, a kind of schneiderian membrance atomized medicine introducing device can be used for nano vaccine inoculation provided by the invention, also has Have the particular feature that i.e., above-mentioned clamping device can rotate and/or adjustable length to be a pair of in the outer surface of liquid accommodating tube body The elastic body of rod;
The end of the above-mentioned elasticity body of rod has clamping piece.
Further, a kind of schneiderian membrance atomized medicine introducing device can be used for nano vaccine inoculation provided by the invention, also has Have the particular feature that i.e., aforesaid liquid storage tube body be the double-layer structure being made of interior tube body and outer tube body;
Above-mentioned clamping device is installed on the outer surface of outer tube body.To play the role of leakproof.
Further, a kind of schneiderian membrance atomized medicine introducing device can be used for nano vaccine inoculation provided by the invention, also has Have the particular feature that i.e., aforesaid liquid storage tube body inner surface be equipped with several angularly disposed elastic spacing ones.To Play the effect being precisely administered.
Further, a kind of schneiderian membrance atomized medicine introducing device can be used for nano vaccine inoculation provided by the invention, also has Have the particular feature that i.e., further include injection head;
Above-mentioned injection head is mounted at liquid accommodating tube body end.So as to pass through the state of replacement injection head Under, realize the absorption of drug.
The action and effect of the utility model:
The utility model realizes the effect for constantly smashing the drug of propulsion using the structure of multilayer dispersion plate, so as to Effectively improve the atomization result of liquid.Meanwhile preferably, be also provided with the structure of intermediate dispersion column, so as into The problem of raising atomizing effect of one step, avoids in traditional equipment, and dropping liquid shape leaks medicine realizes that adult and children noses are super The spray delivery of refinement.
In addition, after fixation in order to realize experimental animal head, thus convenient administering effect, in the present invention also Chucking device is added, can be bonded during not using does not influence to operate with tube wall, in the state of use, by it After being held on the both sides of the head of animal, it is administered in rotatable cartridge.Or it is directly realized by way of rotating clamp structure The fixation on head.
From the point of view of above scheme, the equipment of the utility model is easy to operate, can be directed to the animals such as the mouse of experiment Atomizing administration, realize the more tiny atomizing effect of medical fluid.
Detailed description of the invention
The structural schematic diagram for the schneiderian membrance atomized medicine introducing device that can be used for vaccine inoculation that attached drawing 1, embodiment one are related to.
The structural schematic diagram for the schneiderian membrance atomized medicine introducing device that can be used for vaccine inoculation that attached drawing 2, embodiment two are related to.
The administration atomizer for the schneiderian membrance atomized medicine introducing device that can be used for vaccine inoculation that attached drawing 3, embodiment three are related to Structural schematic diagram.
What attached drawing 4, embodiment one to three were related to can be used for the syringe needle replacement of the schneiderian membrance atomized medicine introducing device of vaccine inoculation Header structure schematic diagram.
Specific embodiment
Embodiment one,
As shown in Figure 1, the present embodiment one provides a kind of schneiderian membrance atomized medicine introducing device that can be used for nano vaccine inoculation, The device is suitable for the schneiderian membrance atomized medicine introducing for experimental animal, including administration atomizer 100 and liquid accommodating tube body 200;
The liquid accommodating tube body 200 is made of riffled tube 210, liquid suction pipe 220 and push-pull rod 230;
Wherein, which is set to the end of liquid suction pipe 220, interior to be equipped with middle pipe 211;
The liquid suction pipe 220 is hollow design, and pipe 211 is connected to bloodletting tube 220 in this;
The push-pull rod 230 is set to inside liquid suction pipe 220, and movement as shown by arrows can be carried out in wherein blank pipe body, To realize the extraction and release of liquid.
The administration atomizer 100 is made of nozzle body, sealing element 114 and atomizing component;
It wherein, is hollow cavity, including beginning 110, middle section 120 and end 122 inside the nozzle body;
The beginning 110 of the nozzle body 100 is pyramidal structure, and sealing element 114 is hospital's elastic rubber, is sheathed on the taper The outside of structure can avoid the medicine of atomization during administration in such a way that the sealing element is filled in medicine-feeding part Object flies out medicine-feeding part.Its top has spray-hole.
The end of the nozzle body 100 is external thread structure, the structure phase of the external thread structure and riffled tube 220 Match, be combineding with each other and removing for the two-part structure can be realized by way of mutually opposing tighten.
Structure and size of pipe 211 and middle section 120 are to matching in this, and after two structures complete installation, pipe 211 is stretched in this Enter in middle section 120, so as to force the fluid into the cavity at beginning 110.
The first dispersion plate 111, the second dispersion plate 112 and end dispersion plate 113 are successively arranged in the beginning 110;Three pieces of plate bodys On be equipped with hole not of uniform size, the effect of liquid through hole is broken up;
The aperture of first dispersion plate 111 is greater than the aperture of the second dispersion plate 112, and the aperture of second dispersion plate 112 is big In the aperture of end dispersion plate 113, so that liquid need to successively lead to after the drug in liquid accommodating tube body 200 is pressed into middle pipe 120 It crosses the first dispersion plate 111, the second dispersion plate 112 and end dispersion plate 113 to be dispersed layer by layer, keeps the drop of macromolecular continuous It reduces until the liquid being released from the dispersion plate 113 of end is mist.
It is additionally provided with handle 121 on the outer surface in the middle section 120, the dismounting of nozzle and cylinder can be convenient for.
Embodiment two,
As shown in Fig. 2, the present embodiment two provides a kind of schneiderian membrance atomized medicine introducing device that can be used for nano vaccine inoculation, The device is suitable for the schneiderian membrance atomized medicine introducing for experimental animal, including administration atomizer 100 and liquid accommodating tube body 200;
The liquid accommodating tube body 200 is made of riffled tube 210, liquid suction pipe 220 and push-pull rod 230;
Wherein, which is set to the end of liquid suction pipe 220, interior to be equipped with middle pipe 211;
The liquid suction pipe 220 is hollow design, and pipe 211 is connected to bloodletting tube 220 in this;
The push-pull rod 230 is set to inside liquid suction pipe 220, and movement as shown by arrows can be carried out in wherein blank pipe body, To realize the extraction and release of liquid.
The both sides external of the liquid suction pipe 220 is set there are two clamping device;
The clamp structure is made of pedestal 221, rotation axis 222, the elastic body of rod 223 and end grip block 224;
The pedestal 221 is fixed on the outer tube wall of liquid suction pipe 220, and rotation axis 222 is rotatably mounted in pedestal 221 Heart position can be rotated with arrow as shown in the figure, which is fabricated for elastic material, can be certain Carry out stretching adjusting in width range, the end of installation and rotation axis 222, so as to rotation axis 222 along the outer of liquid suction pipe Tube wall is rotated.The end of the elasticity body of rod 223 is equipped with grip block 224, and the surface area of the grip block 224 is greater than elastic rod Body can clamp face or the neck of toy.
During use, it can first be about to the clamping device and turn to position such as figure, two pieces of grip blocks 224 are pressed from both sides After experimental animal face, the injection of drug is carried out.
Alternatively, be also possible to after the clamping device is clamped in experimental animal face from any angle, it is entire by rotating The angle of nozzle and cylinder is directed at the effect of administration to realize.
The body of rod generally has the structure of adjustable length, to be able to achieve the different dosing regimes for different animals.
The administration atomizer 100 is made of nozzle body, sealing element 114 and atomizing component;
It wherein, is hollow cavity, including beginning 110, middle section 120 and end 122 inside the nozzle body;
The beginning 110 of the nozzle body 100 is pyramidal structure, and sealing element 114 is hospital's elastic rubber, is sheathed on the taper The outside of structure can avoid the medicine of atomization during administration in such a way that the sealing element is filled in medicine-feeding part Object flies out medicine-feeding part.Its top has spray-hole.
The end of the nozzle body 100 is external thread structure, the structure phase of the external thread structure and riffled tube 220 Match, be combineding with each other and removing for the two-part structure can be realized by way of mutually opposing tighten.
Structure and size of pipe 211 and middle section 120 are to matching in this, and after two structures complete installation, pipe 211 is stretched in this Enter in middle section 120, so as to force the fluid into the cavity at beginning 110.
The first dispersion plate 111, the second dispersion plate 112 and end dispersion plate 113 are successively arranged in the beginning 110;Three pieces of plate bodys On be equipped with hole not of uniform size, the effect of liquid through hole is broken up;
The aperture of first dispersion plate 111 is greater than the aperture of the second dispersion plate 112, and the aperture of second dispersion plate 112 is big In the aperture of end dispersion plate 113, so that liquid need to successively lead to after the drug in liquid accommodating tube body 200 is pressed into middle pipe 120 It crosses the first dispersion plate 111, the second dispersion plate 112 and end dispersion plate 113 to be dispersed layer by layer, keeps the drop of macromolecular continuous It reduces until the liquid being released from the dispersion plate 113 of end is mist.
It is additionally provided with handle 121 on the outer surface in the middle section 120, the dismounting of nozzle and cylinder can be convenient for.
Embodiment three,
As shown in figure 3, being improved in the program administration atomizer 100.
The administration atomizer 100 is made of nozzle body, sealing element 114 and atomizing component;
It wherein, is hollow cavity, including beginning 110, middle section 120 and end 122 inside the nozzle body;
The beginning 110 of the nozzle body 100 is pyramidal structure, and sealing element 114 is hospital's elastic rubber, is sheathed on the taper The outside of structure can avoid the medicine of atomization during administration in such a way that the sealing element is filled in medicine-feeding part Object flies out medicine-feeding part.Its top has spray-hole.
The end 122 of the nozzle body 100 is external thread structure, in the external thread structure and above-described embodiment one and two The structure of riffled tube 220 matches, and be combineding with each other for the two-part structure can be realized by way of mutually opposing tighten And dismounting.
The middle section 120 includes middle leading portion and posterior segment, in the structure and size of the posterior segment and embodiment one and two in Pipe 211 matches, and after two structures complete installation, pipe 211 is protruded into middle section 120 in this, so as to force the fluid into beginning In 110 cavity.
Trapezoidal guide ring 123 is equipped in this in leading portion, the flow path during which makes to enter becomes smaller, It is bigger hydraulic to give;
The outlet end of the guide ring 123 is connected with intermediate dispersion tube 115, has been covered with pore in the intermediate dispersion tube 115, When liquid is pressed into intermediate dispersion tube 115, can from being ejected into these pores on the first dispersion plate or on the second dispersion plate, To improve the efficiency and quality of liquid atomization.It the aperture of the pore can be between the first dispersion plate 111 and the second dispersion Between the aperture of plate 112.
The first dispersion plate 111, the second dispersion plate 112 and end dispersion plate 113 are successively arranged in the beginning 110;Three pieces of plate bodys On be equipped with hole not of uniform size, the effect of the liquid through hole after intermediate dispersion tube 115 is broken up is broken up again;
The aperture of first dispersion plate 111 is greater than the aperture of the second dispersion plate 112, and the aperture of second dispersion plate 112 is big In the aperture of end dispersion plate 113, so that liquid need to successively lead to after the drug in liquid accommodating tube body 200 is pressed into middle pipe 120 It crosses the first dispersion plate 111, the second dispersion plate 112 and end dispersion plate 113 to be dispersed layer by layer, keeps the drop of macromolecular continuous It reduces until the liquid being released from the dispersion plate 113 of end is mist.
It is additionally provided with handle 121 on the outer surface in the middle section 120, the dismounting of nozzle and cylinder can be convenient for.
As shown in figure 4, being the replacement syringe needle to match with above three embodiments, the replacement syringe needle is by syringe needle 320 and spray Mouth ontology 310 forms;
It is hollow structure inside the nozzle body 310;
Its top is equipped with syringe needle, can be used for drawing drug;
Its bottom end is equipped with external screw thread pedestal 312, can match with cylinder;
Its outer wall is equipped with handle 311, can be easily installed and dismantle.
In addition, can also be equipped with several inclined plates being arranged to liquid pull-out direction on the liquid suction pipe 220, which is elasticity Medical grade rubber is fabricated.
After liquid quantitative is extracted, due to the barrier effect of the inclined plate, push rod is not easy to push away to liquid under the effect of gravity Outlet slides, and avoids the problem of usage amount inaccuracy caused by drug is omitted.

Claims (10)

1. a kind of schneiderian membrance atomized medicine introducing device that can be used for nano vaccine inoculation, it is characterised in that: including atomizer is administered With liquid accommodating tube body;
Wherein, the liquid accommodating tube body has the structure for extracting liquid and extruding liquid;
The administration atomizer includes nozzle body, sealing element and atomizing component;
The beginning of the nozzle body is pyramidal structure, and top has spray-hole, is internally provided with hollow cavity, end can Disassembly is installed in liquid accommodating tube body;
The sealing element is sheathed at pyramidal structure;
The atomizing component includes the first dispersion layer, the second dispersion layer and atomized spray layer set gradually;
The atomized spray layer is installed on spray-hole.
2. a kind of schneiderian membrance atomized medicine introducing device that can be used for nano vaccine inoculation as described in claim 1, it is characterised in that:
The aperture of first dispersion layer is greater than the second dispersion layer;
The aperture of second dispersion layer is greater than atomized spray layer.
3. a kind of schneiderian membrance atomized medicine introducing device that can be used for nano vaccine inoculation as described in claim 1, it is characterised in that:
The atomizing component further includes intermediate dispersion column;
The intermediate dispersion column penetrates through the first dispersion layer, terminates between the second dispersion layer and the first dispersion layer;
Pore is evenly equipped in the intermediate dispersion column.
4. a kind of schneiderian membrance atomized medicine introducing device that can be used for nano vaccine inoculation as described in claim 1, it is characterised in that:
Twisting resistance handle is additionally provided on the outer surface of the nozzle body end.
5. a kind of schneiderian membrance atomized medicine introducing device that can be used for nano vaccine inoculation as described in claim 1, it is characterised in that:
The end of the nozzle body also has external thread structure;
The one end of the liquid accommodating tube body is equipped with internal thread structure;
The internal thread structure matches with external thread structure.
6. a kind of schneiderian membrance atomized medicine introducing device that can be used for nano vaccine inoculation as described in claim 1, it is characterised in that:
Clamping device is additionally provided on the outer surface of the liquid accommodating tube body.
7. a kind of schneiderian membrance atomized medicine introducing device that can be used for nano vaccine inoculation as claimed in claim 6, it is characterised in that:
The clamping device is that a pair can be in the rotation of the outer surface of liquid accommodating tube body and/or the elastic body of rod of adjustable length;
The end of the elasticity body of rod has clamping piece.
8. a kind of schneiderian membrance atomized medicine introducing device that can be used for nano vaccine inoculation as claimed in claim 6, it is characterised in that:
The liquid accommodating tube body is the double-layer structure being made of interior tube body and outer tube body;
The clamping device is installed on the outer surface of outer tube body.
9. a kind of schneiderian membrance atomized medicine introducing device that can be used for nano vaccine inoculation as described in claim 1, it is characterised in that:
The inner surface of the liquid accommodating tube body is equipped with several angularly disposed elastic spacing ones.
10. a kind of schneiderian membrance atomized medicine introducing device that can be used for nano vaccine inoculation as described in claim 1-9 is any, special Sign is:
It further include injection head;
The injection head is mounted at liquid accommodating tube body end.
CN201821184835.7U 2018-07-25 2018-07-25 A kind of schneiderian membrance atomized medicine introducing device can be used for nano vaccine inoculation Active CN209173132U (en)

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CN201821184835.7U CN209173132U (en) 2018-07-25 2018-07-25 A kind of schneiderian membrance atomized medicine introducing device can be used for nano vaccine inoculation

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111249606A (en) * 2020-02-18 2020-06-09 扬州大学附属医院 Quantitative nasal cavity spraying device

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111249606A (en) * 2020-02-18 2020-06-09 扬州大学附属医院 Quantitative nasal cavity spraying device

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