CN209054115U - A kind of connection diaphragm valve for bioreactor - Google Patents
A kind of connection diaphragm valve for bioreactor Download PDFInfo
- Publication number
- CN209054115U CN209054115U CN201821943423.7U CN201821943423U CN209054115U CN 209054115 U CN209054115 U CN 209054115U CN 201821943423 U CN201821943423 U CN 201821943423U CN 209054115 U CN209054115 U CN 209054115U
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- valve seat
- valve
- bioreactor
- connection
- diaphragm
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Abstract
A kind of connection diaphragm valve for bioreactor, it is installed on bioreactor, the present apparatus is made of valve head and valve seat, no dead angle groove is opened up with the valve head connecting place at the top of the valve seat, the valve head and valve base chamber use diaphragm seal, the two sides of the valve seat are respectively provided with a card handle, extend overhanging nozzle in the lower part of the valve seat, the inside of the valve seat is opened up there are two through-hole, one of them described through-hole runs through from the no dead angle groove to the bottom surface of valve seat, another described through-hole is three way type, it is connected from the no dead angle groove to the overhanging nozzle of the valve seat and with the one side of valve seat, the valve seat lower part is equipped with screw thread.For pilot scale type bioreactor, it avoids and opens up craft piping pressure caused by bypass in the prior art and increase, use sterilization process caused by by-passing valve to complicate and be connected in tank side opening with the deep layer device of tank deck to increase the risk of sterilizing failure, the process for simplifying experiment or production, optimizes experiment effect.
Description
Technical field
The utility model relates to bioreactor field, specially a kind of connection diaphragm valve for bioreactor.
Background technique
Currently, being carried out in cell cultivation process using bioreactor, in order to obtain the cell in bioreactor
Sufficient oxygen needs to cooperate using surface layer air-breather and deep ventilation device to realize, wherein deep ventilation device
It is divided into still air-breather, microvesicle air-breather and bulla air-breather according to the size of filled bubble.It is anti-in pilot scale type biology
It answers in the use process of device, the reason of because of tank body size, needs to carry out the high pressure sterilization of saturated vapor in place before use, it is conventional
Three kinds of deep ventilation devices because of sterilization pressure reason, can spring back over partially liq in filter, in the step that disappears in fact in order to keep away
Exempt from this phenomenon, most producers can increase a by-passing valve in deep ventilation device and tank body, to reach pressure balance requirement.But
This scheme has some drawbacks: 1, pilot reactor tank diameter is smaller, such as occupies a nozzle using a by-passing valve, can make
Craft piping pressure increase；2, increase by-passing valve, sterilization process is made to complicate；3, this bypass scheme is needed in tank side opening and tank
The deep layer device on top is connected, this section of tubing will increase the risk of sterilizing failure.
Utility model content
(1) the technical issues of solving
In view of the deficiencies of the prior art, the utility model provides a kind of connection diaphragm valve for bioreactor, this
Utility model can reach pressure balance when not only having realized the high pressure sterilization of saturated vapor in place, but also can reach without using by-passing valve
Effect, avoid the pipeline that complicates and be arranged of craft piping pressure increase, sterilization process caused by setting by-passing valve and sterilize
The problem of failure.
(2) technical solution
To achieve the above object, the utility model is achieved by the following technical programs: one kind being used for bioreactor
Connection diaphragm valve, be installed on bioreactor and use, the connection diaphragm valve for bioreactor is by valve head and valve
Seat composition, the valve seat top open up no dead angle groove with the valve head connecting place, and the valve head and valve base chamber use diaphragm close
Envelope, the two sides of the valve seat are respectively provided with a card handle, and overhanging nozzle is extended in the lower part of the valve seat, and the inside of the valve seat is opened
If one of them described through-hole runs through from the no dead angle groove to the bottom surface of valve seat there are two through-hole, described in another
Through-hole is three way type, is connected from the no dead angle groove to the overhanging nozzle of the valve seat and with the one side of valve seat, described
Valve seat lower part is equipped with screw thread；
The valve seat of the connection diaphragm valve for bioreactor is integral type stainless steel, and valve head is plastic cement diaphragm valve
Head.
Preferably, the diaphragm is double diaphragm EPDM and PTFE material or single-iris EPDM material.
Preferably, the valve head is plastics or stainless steel valve head, and working mechanism is manual or pneumatic mode.
Preferably, the thread segment of the valve seat lower part can connect the still ventilation sieve of stainless steel.
Preferably, the overhanging nozzle that the valve seat lower part is extended can connect stainless steel microvesicle ventilation endless tube or stainless steel
Pipe.
Preferably, the valve seat is connect by the card handle with bioreactor, and connection type is the connection of hygiene-type cassette.
(3) beneficial effect
The utility model provides a kind of connection diaphragm valve for bioreactor, have it is following the utility model has the advantages that
(1) it is directed to pilot scale type bioreactor, avoids and opens up craft piping pressure caused by bypass in the prior art
Increase, sterilization process caused by by-passing valve is used to complicate and go out in the increase that is connected with the deep layer device of tank deck of tank side opening
The risk of bacterium failure, simplifies the process of experiment or production, optimizes experiment effect.
(2) the utility model is easy to use, separates diaphragm with valve seat by controlling valve head, can be realized what connection was divided into
The equipment such as ventilation endless tube achieve the effect that balance pressure inside the tank have preferable practicability.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the utility model.
In figure: 1, the first venthole, 2, left valve seat, 3, valve head, 4, diaphragm, 5, right valve seat, the 6, second venthole, 7, card
Handle, 8, thread segment, 9, overhanging nozzle, 10, without dead angle groove.
Specific embodiment
The following will be combined with the drawings in the embodiments of the present invention, carries out the technical scheme in the embodiment of the utility model
Clearly and completely describe, it is clear that the described embodiments are only a part of the embodiments of the utility model, rather than whole
Embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art are without making creative work
Every other embodiment obtained, fall within the protection scope of the utility model.
Refering to fig. 1, the utility model provides a kind of technical solution, is installed on bioreactor, and reply is in culture cell
When because of sterilization pressure the reason of partially liq sprung back over into the problems in filter, a kind of connection diaphragm for bioreactor
Valve, including valve head 3 and valve seat, valve seat are divided into left valve seat 2 and right valve seat 5 here, the valve head 3 in the top of the valve seat,
The two is linked together by articulated manner, and no dead angle groove 10, the valve head 3 and valve seat are opened up below the two connecting place
Between sealed using diaphragm 4, diaphragm 4 can will be closed and be opened without dead angle groove 10 with the rotation of valve head 3, and the diaphragm 4 be
An overhanging nozzle 9 is extended in double diaphragm EPDM and PTFE material or single-iris EPDM material, the lower part of the left valve seat 2, long
Degree is 10mm, can be used to connect stainless steel microvesicle ventilation endless tube or stainless steel tube, the inside of the valve seat is in left 2 part of valve seat
A through-hole is respectively offered with right 5 part of valve seat, wherein the first venthole 1 opened up on left valve seat 2 is three way type, equally from institute
It states at no dead angle groove 10 to the overhanging nozzle 9 of the valve seat and is connected with the one side of valve seat, the second ventilation on right valve seat 5
Hole 6 is run through from the no dead angle groove 10 to the bottom surface of valve seat, two through-holes at the no dead angle groove 10 not
It is overlapped, respectively accounts for a part of no dead angle groove 10.
It is described for bioreactor connection diaphragm valve valve seat be integral type stainless steel, the valve head 3 be plastics or
Stainless steel valve head, working mechanism pass through both Working moulds since valve head 3 and valve seat are to be hinged for manual or pneumatic mode
The unlatching and closure of two through-holes in valve seat, the left valve seat 2 and right valve are realized in formula rotary valve head 3, the rotation with dynamic diaphragm 4
Seat 5 is respectively provided with a card handle 7, and the effect of card handle 7 is to connect with bioreactor, and connection type is the connection of hygiene-type cassette,
The lower part of valve seat is equipped with thread segment 8, can connect the still ventilation sieve of stainless steel.
Action principle: a kind of connection diaphragm valve for bioreactor of the utility model opens up two-way through-hole in valve seat,
Top is connect with valve head 3, valve head 3 can carry the rotation of diaphragm 4 realize to the sealing of through-hole in valve seat be connected to, valve seat lower part extends
Overhanging nozzle 9 out can connect stainless steel microvesicle ventilation endless tube or stainless steel tube, realize the connection with external aeration device, answering
When for pilot scale type bioreactor, by the unlatching and closure of valve head 3, cooperate air-breather realize to cell cultivation process into
Row oxygenation.
Implementation process is as follows: the present apparatus being installed on bioreactor tank body, the overhanging nozzle 9 of valve seat lower part and ventilation fill
The stainless steel microvesicle ventilation endless tube set or stainless steel tube connection, under 3 closed state of valve head, diaphragm 4 and no dead angle groove 10 are tight
Sealing state is realized in closely connected conjunction；In the state that in sterilizing, valve head 3 is opened, two through-holes become connected state, and gas passes through two
Through-hole enters in tank, and two holes and tank interior is made to reach pressure balance, at the end of preventing because of sterilizing, is formed caused by negative pressure in tank
Tank inner connecting tube liquid is flow backwards.
It should be noted that, in this document, relational terms such as first and second and the like are used merely to a reality
Body or operation are distinguished with another entity or operation, are deposited without necessarily requiring or implying between these entities or operation
In any actual relationship or order or sequence.Moreover, the terms "include", "comprise" or its any other variant are intended to
Non-exclusive inclusion, so that the process, method, article or equipment including a series of elements is not only wanted including those
Element, but also including other elements that are not explicitly listed, or further include for this process, method, article or equipment
Intrinsic element.In the absence of more restrictions.By sentence " element limited including one ..., it is not excluded that
There is also other identical elements in the process, method, article or apparatus that includes the element ".
Obviously, the above embodiments of the present invention is merely examples for clearly illustrating the present invention, and
It is not limitations of the embodiments of the present invention.For those of ordinary skill in the art, in above description
On the basis of can also make other variations or changes in different ways.There is no need and unable to give all embodiments
Exhaustion.Any modifications, equivalent replacements, and improvements made within the spirit and principle of the present invention etc., should be included in
Within the protection scope of the utility model claims.
Claims (6)
1. a kind of connection diaphragm valve for bioreactor, is installed on bioreactor, it is characterised in that: described for giving birth to
The connection diaphragm valve of object reactor is made of valve head and valve seat, and it is recessed with the valve head connecting place to open up no dead angle at the top of the valve seat
Slot, the valve head and valve base chamber use diaphragm seal, and the two sides of the valve seat are respectively provided with a card handle, and the lower part of the valve seat is prolonged
Stretch out overhanging nozzle, the inside of the valve seat is opened up there are two through-hole, one of them described through-hole is from the no dead angle groove
Run through to the bottom surface of valve seat, another described through-hole is three way type, from the no dead angle groove to the valve seat projecting tube
Mouth is simultaneously connected with the one side of valve seat, and the valve seat lower part is equipped with screw thread；
The valve seat of the connection diaphragm valve for bioreactor is integral type stainless steel, and valve head and valve seat hinge are connected to valve seat
End face center.
2. the connection diaphragm valve according to claim 1 for bioreactor, it is characterised in that: the diaphragm is double films
Piece EPDM and PTFE material or single-iris EPDM material.
3. the connection diaphragm valve according to claim 1 for bioreactor, it is characterised in that: the valve head is plastics
Or stainless steel valve head, working mechanism are manual or pneumatic mode.
4. the connection diaphragm valve according to claim 1 for bioreactor, it is characterised in that: the valve seat lower part
Thread segment can connect the still ventilation sieve of stainless steel.
5. the connection diaphragm valve according to claim 1 for bioreactor, it is characterised in that: prolong the valve seat lower part
The overhanging nozzle stretched out can connect stainless steel microvesicle ventilation endless tube or stainless steel tube.
6. the connection diaphragm valve according to claim 1 for bioreactor, it is characterised in that: the valve seat passes through institute
It states card handle to connect with bioreactor, connection type is the connection of hygiene-type cassette.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821943423.7U CN209054115U (en) | 2018-11-23 | 2018-11-23 | A kind of connection diaphragm valve for bioreactor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821943423.7U CN209054115U (en) | 2018-11-23 | 2018-11-23 | A kind of connection diaphragm valve for bioreactor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209054115U true CN209054115U (en) | 2019-07-02 |
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ID=67054411
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821943423.7U Active CN209054115U (en) | 2018-11-23 | 2018-11-23 | A kind of connection diaphragm valve for bioreactor |
Country Status (1)
| Country | Link |
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| CN (1) | CN209054115U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111467126A (en) * | 2020-03-12 | 2020-07-31 | 聊城市人民医院 | Auxiliary eye dropping device |
| GB2609490A (en) * | 2021-08-05 | 2023-02-08 | Oribiotech Ltd | Outlet valve for a container |
-
2018
- 2018-11-23 CN CN201821943423.7U patent/CN209054115U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111467126A (en) * | 2020-03-12 | 2020-07-31 | 聊城市人民医院 | Auxiliary eye dropping device |
| GB2609490A (en) * | 2021-08-05 | 2023-02-08 | Oribiotech Ltd | Outlet valve for a container |
| WO2023012469A1 (en) * | 2021-08-05 | 2023-02-09 | Oribiotech Ltd | Outlet valve for a container |
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