CN209019031U - A kind of visceral sensitivity in rats measurement device - Google Patents
A kind of visceral sensitivity in rats measurement device Download PDFInfo
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- CN209019031U CN209019031U CN201820187060.2U CN201820187060U CN209019031U CN 209019031 U CN209019031 U CN 209019031U CN 201820187060 U CN201820187060 U CN 201820187060U CN 209019031 U CN209019031 U CN 209019031U
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Abstract
The utility model belongs to the technical field of experimental animal device, discloses a kind of visceral sensitivity in rats measurement device, is provided with activities in rats limitation cage and sphygmomanometer；Sphygmomanometer removes restraining, connects tee tube；The tee tube other side connects one section of catheter, pricks upper air bag in catheter front end with surgical thread, tee tube middle port is connected with disposable syringe.Sphygmomanometer connects air bag；Air bag connects catheter；Catheter connects tee tube；Tee tube connects syringe.The fixation device construction of the utility model is reasonable, easy to operate, easy to use, and energy objective appraisal intestine in rats sensibility is suitable for scientific research institutions, medical institutions and pharmacy corporation laboratory etc..
Description
Technical field
The utility model belongs to the technical field more particularly to a kind of measurement of visceral sensitivity in rats of experimental animal device
Device
Background technique
Enteron aisle is digest tube of the stomach pylorus to anus, is longest one section in digest tube, mainly includes small intestine, large intestine and straight
The big section of intestines 3, and small intestine is divided into duodenum, jejunum and ileum, large intestine is divided into caecum, colon and rectum.Intestinal tract conduct
Digestive organs, immune organ and the toxin expelling organ of Chinese medicine have nervus opticus maincenter and brain tissue as human body to form brain-intestines
Axis (brain-gut axis) and multiple disease location.
Intestines problem it is common include Crohn disease (Crohndisease, CD), ulcerative colitis, irritable bowel syndrome
(Irritable bowel syndrome, IBS) etc..Crohn disease is also known as regional enteritis, regional enteritis, segmental
Enteritis and granulomatous enteritis are a kind of bowl inflammatory diseases that reason is unknown, with abdominal pain, diarrhea, intestinal obstruction for main disease
Shape, and the parenteral performance such as have fever, dystrophia.Ulcerative colitis is a kind of inflammation for being confined to mucous membrane of colon and submucosa
Disease process.Disease is much located at sigmoid colon and rectum, also may extend to colon descendens or even entire colon.Pathology is very long, Chang Fanfu
Breaking-out.Irritable bowel syndrome is a kind of gastrointestinal dysfunction disease, it is characterized in that abdominal pain, abdominal distension, constipation or diarrhea.These three are often
The intestines problem seen is with the significantly raised performance of enteron aisle sensibility.
At present Crohn disease, irritable bowel syndrome pathogenesis be still not clear, also lack that curative for effect adverse reaction is few
Immunotherapy targeted autoantibody drug, pathogenesis and new drug development research be a current big hot spot.The raising of enteron aisle sensibility is intestines
The classical feature of one of tract disease, the enteron aisle sensibility for how measuring enteron aisle sensibility especially experimental animal there is no instrument.
Summary of the invention
In view of the problems of the existing technology, the utility model provides a kind of visceral sensitivity in rats measurement device.
The utility model is realized in this way a kind of visceral sensitivity in rats measurement device is provided with activities in rats limitation
Cage and sphygmomanometer composition.Wherein, sphygmomanometer removes restraining, connects tee tube；The tee tube other side connects one section of catheter,
Upper air bag is pricked with surgical thread in catheter front end, tee tube middle port is connected with disposable syringe.
Further, air bag is rubber material.
Further, activities in rats limitation cage is transparent organic glass material or glass material or transparent plastics material, rat
Wherein can only fore-aft travel, cannot turn round.
Further, it is conventional commercially available scientific research consumptive material that this, which tests other,.
Further, syringe and tee tube are insertion connection.
The advantages of the utility model and good effect are as follows: the fixation device construction of the utility model is reasonable, easy to operate, makes
With conveniently；Air can be injected into air bag by syringe, heave air bag inflation and cause to stimulate, rat stomach wall is to enteric cavity sacculus
Expansion generate stress reaction the reading of sphygmomanometer read according to its degree of having strong complaints, thus with the reading objective appraisal
Intestine in rats sensibility.The utility model can make up the excessively subjective disadvantage of existing enteron aisle sensitivity assessment, with objectively, can measure
The numerical value of change is evaluated, more scientific reasonable, is widely used in scientific research institutions, medical institutions and pharmacy corporation laboratory etc..
Detailed description of the invention
Fig. 1 is the self-control manometry in rectum meter structure of visceral sensitivity in rats measurement device provided by the embodiment of the utility model
Schematic diagram.
Fig. 2 is the activities in rats limitation cage signal of visceral sensitivity in rats measurement device provided by the embodiment of the utility model
Figure.
Fig. 3 is rat AWR scoring figure provided by the embodiment of the utility model；
In figure: 1, sphygmomanometer；2, catheter；3, air bag；4, tee tube；5, syringe；6, activities in rats limits cage.
Specific embodiment
For the invention, features and effects that can further appreciate that the utility model, the following examples are hereby given, and cooperates
Detailed description are as follows for attached drawing.
The structure of the utility model is explained in detail with reference to the accompanying drawing.
As shown in attached drawing 1- attached drawing 3, visceral sensitivity in rats measurement device provided by the embodiment of the utility model is provided with
Activities in rats limits cage 6 and sphygmomanometer 1；Sphygmomanometer 1 connects air bag 3；Air bag 3 connects catheter 2；Catheter 2 connects threeway
Pipe 4；Tee tube 4 connects syringe 5.
Further, air bag is rubber material.
Further, activities in rats limitation cage 6 is transparent organic glass material or glass material or transparent plastics material, rat
Wherein can only fore-aft travel, cannot turn round.
Further, it is conventional commercially available scientific research consumptive material that this, which tests other,.
Further, syringe 5 and tee tube 4 are insertion connection.
Tee tube coupling part need to be placed in water by the utility model before, detect whether gas leakage；
Working principle of the utility model is: referring to abdomen rebound reflex (abdominal withdrawal reflex,
AWR) standards of grading randomly select each group rat 10 using self-control manometry in rectum meter, the 1st, 7,14 after Yu Zaomo respectively
It carries out visceral sensitivity evaluation.Each group Rat Fast can't help water for 24 hours before testing, and the band of paraffin oil will be coated under waking state
The 8F catheter 2 of air bag 3 is inserted into anus about 6cm, and catheter 2 is fixed on rat root of the tail portion, prevents its sliding from falling off.Then
Rat is placed in homemade transparent glass cage 6, make its can only fore-aft travel, cannot turn round.After 10min slowly with syringe 5
It is inflated into air bag 3, observes reaction of the rat stomach wall to enteric cavity balloon expandable.It take AWR scoring as the pressure threshold of 3 timesharing
(mmHg) as the pain threshold won in rat.To avoid error and subjective bias, every rat carries out 3 balloon expandables, often
It is secondary to continue 20s, it is spaced 5min, takes average pressure value；Whole experiment process operates completion by 2 people, and experimental implementation person is responsible for sacculus
Insertion and recording laboratory animal number and grouping situation, Germicidal efficacy person be responsible for sacculus gas injection and observe rat behaviouristics it is anti-
It answers, determines and records that rat AWR scoring is the pressure value of 3 timesharing, and Germicidal efficacy person does not know number of animals and grouping situation；
In addition, to avoid the influence of biological rhythm, AWR scoring carries out between 1:00~5:00 in the afternoon.
AWR standards of grading:
0 point, rat is without significant change when giving balloon expandable stimulation；1 point, rat mood is not when giving balloon expandable stimulation
Stablize, body is stationary, and head twists or moves up and down once in a while；2 points, abdominal muscles bounce back when giving balloon expandable stimulation,
But abdominal muscle does not leave target face；3 points, give balloon expandable stimulation when the stronger contraction of rat abdomen muscle, abdominal muscles raise from
Open desktop；4 points, rat abdomen muscle strong contraction when giving balloon expandable stimulation, abdomen is arched, and pelvis lifts.
The fixation device construction of the utility model is reasonable, easy to operate, easy to use, and energy objective appraisal intestine in rats is quick
Perception is suitable for scientific research institutions, medical institutions and pharmacy corporation laboratory etc..
The above is only the preferred embodiment to the utility model, is not made in any form to the utility model
Limitation, it is all according to the technical essence of the utility model any simple modification made to the above embodiment, equivalent variations with
Modification, is all within the scope of the technical scheme of the utility model.
Claims (3)
1. a kind of visceral sensitivity in rats measurement device, which is characterized in that the visceral sensitivity in rats measurement device is provided with
Sphygmomanometer；
The sphygmomanometer connects air bag；The air bag connects catheter；The catheter connects tee tube；The tee tube connection
Syringe.
2. visceral sensitivity in rats measurement device as described in claim 1, which is characterized in that the syringe and tee tube are inserted
Enter connection.
3. a kind of activities in rats limitation cage for being placed with mouse visceral sensitivity measurement device described in claim 1, which is characterized in that
The mouse visceral sensitivity measurement device is placed on inside activities in rats limitation cage.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820187060.2U CN209019031U (en) | 2018-02-02 | 2018-02-02 | A kind of visceral sensitivity in rats measurement device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820187060.2U CN209019031U (en) | 2018-02-02 | 2018-02-02 | A kind of visceral sensitivity in rats measurement device |
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| Publication Number | Publication Date |
|---|---|
| CN209019031U true CN209019031U (en) | 2019-06-25 |
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| CN201820187060.2U Expired - Fee Related CN209019031U (en) | 2018-02-02 | 2018-02-02 | A kind of visceral sensitivity in rats measurement device |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113412817A (en) * | 2021-05-31 | 2021-09-21 | 成都中医药大学附属医院 | IBS-D experimental animal model method for improving molding rate and reducing death rate |
| CN113647907A (en) * | 2021-08-06 | 2021-11-16 | 温州市人民医院 | Laboratory mouse intestinal sensitivity test equipment |
-
2018
- 2018-02-02 CN CN201820187060.2U patent/CN209019031U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113412817A (en) * | 2021-05-31 | 2021-09-21 | 成都中医药大学附属医院 | IBS-D experimental animal model method for improving molding rate and reducing death rate |
| CN113647907A (en) * | 2021-08-06 | 2021-11-16 | 温州市人民医院 | Laboratory mouse intestinal sensitivity test equipment |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20190625 Termination date: 20210202 |