CN209004926U - Throat sprayer for filling stem cell active peptide medicament - Google Patents
Throat sprayer for filling stem cell active peptide medicament Download PDFInfo
- Publication number
- CN209004926U CN209004926U CN201721888089.5U CN201721888089U CN209004926U CN 209004926 U CN209004926 U CN 209004926U CN 201721888089 U CN201721888089 U CN 201721888089U CN 209004926 U CN209004926 U CN 209004926U
- Authority
- CN
- China
- Prior art keywords
- stem cell
- suction pipe
- pipe
- victory peptide
- cell activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 210000000130 stem cell Anatomy 0.000 title claims abstract description 67
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 53
- 239000003814 drug Substances 0.000 title claims abstract description 40
- 238000011049 filling Methods 0.000 title claims description 9
- 230000000694 effects Effects 0.000 claims abstract description 45
- 210000000867 larynx Anatomy 0.000 claims abstract description 26
- 238000003825 pressing Methods 0.000 claims description 22
- 230000006835 compression Effects 0.000 claims description 12
- 238000007906 compression Methods 0.000 claims description 12
- 239000007921 spray Substances 0.000 claims description 4
- 230000002093 peripheral effect Effects 0.000 claims description 3
- 238000000889 atomisation Methods 0.000 claims 1
- 210000004400 mucous membrane Anatomy 0.000 abstract description 7
- 230000004888 barrier function Effects 0.000 abstract description 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 description 21
- 108090000623 proteins and genes Proteins 0.000 description 8
- 230000028327 secretion Effects 0.000 description 8
- 239000000853 adhesive Substances 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- 229920000715 Mucilage Polymers 0.000 description 6
- 230000004069 differentiation Effects 0.000 description 6
- 210000001671 embryonic stem cell Anatomy 0.000 description 5
- 210000000214 mouth Anatomy 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 5
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- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 2
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- 229910052623 talc Inorganic materials 0.000 description 2
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
- 210000002444 unipotent stem cell Anatomy 0.000 description 2
- RYDFXSRVZBYYJV-TYYBGVCCSA-N (e)-but-2-enedioic acid;sodium Chemical compound [Na].OC(=O)\C=C\C(O)=O RYDFXSRVZBYYJV-TYYBGVCCSA-N 0.000 description 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 239000005995 Aluminium silicate Substances 0.000 description 1
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- 239000004471 Glycine Substances 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 239000005913 Maltodextrin Substances 0.000 description 1
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- 229930195725 Mannitol Natural products 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
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- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 102000007079 Peptide Fragments Human genes 0.000 description 1
- 108010033276 Peptide Fragments Proteins 0.000 description 1
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- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- SPTSIOTYTJZTOG-UHFFFAOYSA-N acetic acid;octadecanoic acid Chemical compound CC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O SPTSIOTYTJZTOG-UHFFFAOYSA-N 0.000 description 1
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- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 description 1
- 239000000920 calcium hydroxide Substances 0.000 description 1
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- 229960001714 calcium phosphate Drugs 0.000 description 1
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- UBWYRXFZPXBISJ-UHFFFAOYSA-L calcium;2-hydroxypropanoate;trihydrate Chemical compound O.O.O.[Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O UBWYRXFZPXBISJ-UHFFFAOYSA-L 0.000 description 1
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- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
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- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
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- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/006—Sprayers or atomisers specially adapted for therapeutic purposes operated by applying mechanical pressure to the liquid to be sprayed or atomised
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
- A61M11/02—Sprayers or atomisers specially adapted for therapeutic purposes operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0625—Mouth
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/0005—Components or details
- B05B11/0089—Dispensing tubes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
- B05B—SPRAYING APPARATUS; ATOMISING APPARATUS; NOZZLES
- B05B11/00—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use
- B05B11/01—Single-unit hand-held apparatus in which flow of contents is produced by the muscular force of the operator at the moment of use characterised by the means producing the flow
- B05B11/10—Pump arrangements for transferring the contents from the container to a pump chamber by a sucking effect and forcing the contents out through the dispensing nozzle
- B05B11/1001—Piston pumps
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mechanical Engineering (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
The utility model discloses a supply to load larynx atomizer of stem cell active peptide medicament includes at least: press the body, fixed cover, container and pressurization subassembly, be filled with stem cell activity victory peptide medicament in this container, utilize and press body control pressurization subassembly, can draw stem cell activity victory peptide medicament in the container in order to spout through the nozzle and then atomizing, the utility model is suitable for a transmit victory peptide class active ingredient by throat mucous membrane tissue, by the physics nature barrier that the atomizer constitutes for the throat, keep apart external moisture, air and light for victory peptide class active ingredient maintains its activity and stability in the save period.
Description
Technical field
The utility model is sprayed in relation to a kind of larynx sprayer, espespecially a kind of larynx for filling Stem Cell Activity victory peptide medicament
Day with fog.
Background technique
The intracorporal most of composition of body, be all often it is mature break up complete cell, such as Skin Cell, liver are thin
Born of the same parents or Stomatocyte.The characteristic of these cells is typically considered to cell under not any external force stimulation or mutation
Destiny determined that will not be changed into other cells again, such cell is commonly referred to as " body cell " (somatic cell).And
Stem cell is then that the body cell for having broken up completion with these has significant otherness.Stem cell refers to not yet complete differentiation, and has
There is " differentiation capability " (differentiation), and the initial cell of two or more mature cells can be divided into, it can be in body
It is interior by miscellaneous stimulation, to change cell fate, be divided into specific cell.
Stem cell is classified with differentiation capability, myeloid-lymphoid stem cell (totipotent stem cell), omnipotent dry can be divided into
Cell (pluripotent stem cell), multipotential stem cell (multipotent stem cell) and unipotent stem cell
(unipotent stem cell)；It is separately distinguished according to source of human stem cell, then can be divided into embryonic stem cell (embryonic stem
Cell), adult stem cell (somatic stem cell) and induction type universal stem cell (induced pluripotent
stem cell；iPSC).Wherein, hESC belongs to universal stem cell, within blastaea period before non-implantation
Cell mass has versatility and can be divided into various adult cells；Another person, induction type universal stem cell is then to force performance
Specific gene or protein, are imported differentiated body cell, keep the body thin by the mode of (enforced expression) operation
Born of the same parents are become similar embryonic stem cell person by sequencing again (reprogrammed).Think that stem cell is useful according to medical research
In the potentiality of repair tissue or organ, it is a variety of to can apply to treating cancer, repairing organ, new drug development, manufacture man-made organ etc.
Using the mankind can be changed to the countermeasure of disease.
In the past, the dispensing of the drugs such as pharmacological activity victory peptide or protein matter, mainly to intravenously or subcutaneously with injection system
It offers medicine.However, often resulting in very big mentally burden or human body pain for patients by the administration of medication of injection
Hardship, or have the problem for the inconvenience such as difficulty of voluntarily being offerd medicine by patient.Therefore, in recent years, with glutinous via lung mucous membrane, schneiderian membrance, oral cavity
The approach that the mucous membranes such as film, throat mucous membrane, vaginal mucosa, stomach lining, digest tube mucous membrane are offerd medicine is as the drug other than injection
Dosing way has started to attract attention.
Therefore, the utility model technical field needs a kind of new and useful larynx sprayer, and it is suitable for via throat
Mucous membrane tissue carries out the transmission of victory peptide active component, and so as to the mechanical barrier constituted by larynx sprayer, isolation is outer
Moisture, air and the light on boundary, the peptides active constituent that makes to win victory maintain its activity and stability during storage life.
Utility model content
The technical issues of the utility model is solved is providing a kind of larynx sprayer, espespecially a kind of for loading stem cell
The larynx sprayer of activity victory peptide medicament.
Technological means used by the utility model is as described below.
The larynx sprayer of the utility model, which includes at least, to be had: with the pressing body of elongated nozzle, fixing sleeve, container and
Pressure-applying unit, pressing body have the socket pipe of a hollow framework, internal and one sparge pipe of landscape configuration, one end of the sparge pipe
It is at right angles bent to form one first spurt hole towards the lower section portion of the pressing body, the other end of the sparge pipe then extends to the socket pipe
Outer peripheral surface, and be laterally equipped with one and protrude from elongated nozzle outside pressing body, which is then formed with one
Two spurt holes；The pressing body is accepted in a cover mouth upwards by fixing sleeve upper section portion, and center sets a perforative perforation for the sparge pipe
One end place wherein；Container corresponds to the lower section portion that fitting is fixed on the fixing sleeve, and Stem Cell Activity victory is filled in the container
Peptide medicament；Pressure-applying unit is installed at the perforation of the fixing sleeve, draws suction pipe part equipped with one, this draws suction pipe part one end and penetrates with the appearance
Device bottom, the other end are then exposed to the running-on of the fixing sleeve, and are removably connected to one end of the sparge pipe, using pressing
Laminate controls pressure-applying unit, can draw the Stem Cell Activity victory peptide medicament in container to be atomized ejection by nozzle.
According to above-mentioned technical characteristic, the Stem Cell Activity victory peptide medicament is derived from the mucilage secretion of stem cell.
According to above-mentioned technical characteristic, the stem cell is the embryonic stem cell picked up from embryo, or is picked up from organism
Marrow, Cord blood, peripheral blood or adipose tissue adult stem cell.
According to above-mentioned technical characteristic, the stem cell is to import body cell by by specific gene or specific gene product
What is inside made has the inductivity versatile stem cell (induced pluripotent stem cells) of differentiation capability again.
According to above-mentioned technical characteristic, the stem cell be pick up from it is tough in marrow, Cord blood, adipose tissue, pulp cavity, periodontal
The mescenchymal stem cell (mesenchymal stem cells, abbreviation MSC) of band or joint fluid.
According to above-mentioned technical characteristic, the suction pipe part that draws of the pressure-applying unit draws suction pipe, containing tube and suction pipe configured with one,
This, which draws suction pipe bottom end and wears one first spring, is followed by setting a taper sheath, which wears one compression bar of group, and the compression bar tail end is again
One second spring is set, which is arranged a ball, and the containing tube is for drawing suction pipe, the first spring, cone for above-mentioned
Shape set, compression bar, second spring and ball are from top to bottom sequentially placed in pipe, and are socketed on the suction pipe in the containing tube bottom end.
According to above-mentioned technical characteristic, the upper section portion drawn suction pipe upper section portion and protrude from the fixing sleeve.
According to above-mentioned technical characteristic, the pressing body is detachably fixed on the upper section portion of the fixing sleeve.
According to above-mentioned technical characteristic, the fixing sleeve is further installed with a protection cap, which covers this and draw suction pipe.
Technical effect caused by the utility model: the larynx of the utility model with sprayer not only for victory peptides activity at
Divide and adequately protection is provided, and take into account the high-transmission efficiency of victory peptide active component, and compared to other dosing ways, via nose
Mucous membrane dispensing has quickly absorption, high bioavailability and the advantages such as effect quickly occurs.
Detailed description of the invention
Fig. 1 show the structural perspective of larynx sprayer in the utility model.
Fig. 2 show the structure sectional view of larynx sprayer in the utility model.
Fig. 3 show the structural exploded view of larynx sprayer in the utility model.
Fig. 4 show the use schematic diagram of larynx sprayer in the utility model.
Fig. 5 show another structural perspective of larynx sprayer in the utility model.
Figure number explanation:
Larynx sprayer 1
Pressing body 10
Socket pipe 11
Elongated nozzle 12
Second spurt hole 121
Sparge pipe 13
First spurt hole 131
Fixing sleeve 20
Cover mouth 21
Perforation 22
Container 30
Pressure-applying unit 40
Draw suction pipe part 400
Draw suction pipe 41
Second assembled portion 411
First spring 42
Taper sheath 43
Compression bar 44
Second spring 45
Ball 46
Containing tube 47
Suction pipe 48
Stem Cell Activity wins peptide medicament 50
Protection cap 60.
Specific embodiment
It please refers to Fig. 1 to show in the utility model shown in the structural perspective of larynx sprayer, Fig. 2 show practical
Shown in the structure sectional view of novel middle larynx sprayer.Firstly, the larynx sprayer 1 of the utility model includes at least: pressing body
10, fixing sleeve 20, container 30 and pressure-applying unit 40, in which: it has the socket pipe 11 of a hollow framework to pressing body 10, in
Portion and one sparge pipe 13 of landscape configuration, the lower section portion of one end towards the pressing body 10 of the sparge pipe 13 are at right angles bent to form one the
One spurt hole 131, the other end of the sparge pipe 13 then extend to the outer peripheral surface of the socket pipe 11, and are laterally equipped with one and protrude from
Elongated nozzle 12 outside pressing body 10, the free end of the elongated nozzle 12 are then formed with one second spurt hole 121, wherein sparge pipe
13 and elongated nozzle 12 and socket pipe 11 inside then form communicating state.
Its upper section portion of fixing sleeve 20 is in that a cover mouth 21 accepts pressing body 10 upwards, and center sets a perforative perforation 22 for being somebody's turn to do
One end of sparge pipe 13 places wherein.
The corresponding fitting of container 30 is fixed on the lower section portion of the fixing sleeve 20, and Stem Cell Activity victory peptide is filled in the container 30
Medicament 50.
Pressure-applying unit 40 is installed at the perforation 22 of the fixing sleeve 20, which is equipped with one and draws suction pipe part 400, should
It drawing 400 one end of suction pipe part and penetrates with 30 bottom of container, the other end is then exposed to the running-on 21 in the 20 upper section portion of fixing sleeve, and with
Removably is connected at first spurt hole 131 of one end of the sparge pipe 13, this draws suction pipe part can be by the socket pipe 12
It controls and draws the victory peptide medicament of the Stem Cell Activity in the container 30 to be atomized ejection by the nozzle；In a preferred tool
In body embodiment, please refer to shown in the 3rd figure, the suction pipe part 400 that draws of pressure-applying unit 40 draws suction pipe 41, containing tube 47 by one
And suction pipe 48 is constituted, and the upper section portion that 41 upper section portion of suction pipe protrudes from the fixing sleeve 20 is drawn, and is drawn 41 bottom end of suction pipe and is worn one
One spring 42 is followed by setting a taper sheath 43, and one compression bar 44 of group is worn in 43 bottom of taper sheath, and a second spring is arranged in 44 tail end of compression bar again
45,45 another end of second spring be arranged a ball 46, containing tube 47 for by it is above-mentioned draw suction pipe 41, the first spring 42, taper sheath 43,
Compression bar 44, second spring 45 and ball 46 are from top to bottom sequentially placed in pipe, and are socketed on the suction pipe in 47 bottom end of containing tube
48.Certainly, pressure-applying unit can also be provided only with a spring in this case, or to have in the utility model technical field
Used structure in spray bottle known to usual skill.
As user in use, please refer to shown in the 4th figure, user can go deep into throat by elongated nozzle 12,
Pressing body 10 is forced in hand again, sprays air moment in container 30 toward nozzle 11, while because of the effect of siphon, will press
Stem Cell Activity victory peptide medicament in body 10 enters in containing tube 47 with air from suction pipe 48 together, at this point, because of second spring 45
Stretching elasticity relationship, enable 43 bottom of compression bar push down ball 45, so that ball 46 is blocked the mouth hole of containing tube 47, and make compression bar 44
Gap space is generated with taper sheath 43, Stem Cell Activity in containing tube 47 is made to win peptide medicament along gap space towards outside compression bar 44
Edge infiltration is drawn in suction pipe 41, then sprays medicament from the second spurt hole 121 of nozzle 11 with air via suction pipe 41 is drawn, and works as relieving
When pressing body 10, the Stem Cell Activity victory peptide medicament in container 30 enters in containing tube 47 with air from suction pipe 48 again again.
In addition, pressing body is removably fixed on the running-on 21 in the 20 upper section portion of fixing sleeve, as shown in Figures 3 and 4
Embodiment in, by sparge pipe 13 and suction pipe 41 can be drawn be designed as the configuration that can be mutually socketed, such as sparge pipe 13
Internal diameter is slightly larger than the outer diameter (as illustrated in the exemplary embodiment of figure 3) for drawing suction pipe 41, or draws the internal diameter of suction pipe 41 slightly larger than sparge pipe 13
Outer diameter (not shown), using sparge pipe 13 and draw suction pipe 41 mutually socket engaging effect, pressing body 10 can be allowed with removable
Dress mode is fixed on the upper section portion of the fixing sleeve 20；And the fixing sleeve 20 is further installed with a protection cap 60, when pressing body 10
After disassembly, which is securable to the fixing sleeve 20 and covers this to draw outside suction pipe 41, draws suction pipe 41 to close this with right
Stem Cell Activity victory peptide medicament 50 in container 30 provides more preferably protecting effect.
This case " Stem Cell Activity win peptide medicament " this term used in the description mean from stem cell-derived and
Itself or its metabolite victory peptides pharmaceutical material active on medicine or nutrition, may include full length protein
And its win peptide fragment, the metabolite of they or catabolite and combinations thereof object and mixture.In preferable concrete example
In, this case Stem Cell Activity victory peptide medicament is derived from the mucilage secretion of stem cell.The stem cell can be all-round
(totipotent), omnipotent (pluripotent), multipotential stem cell (multipotent) or single energy (unipotent) are dry thin
Born of the same parents.For the source of stem cell, they can be the embryonic stem cell picked up from embryo, or pick up from such as organism
Marrow, Cord blood, peripheral blood or adipose tissue adult stem cell, even by by specific gene or specific gene product
Import inductivity versatile stem cell (the induced pluripotent stem again with differentiation capability made in body cell
cells).In preferable concrete example, the stem cell is multipotential stem cell, such as is picked up from marrow, Cord blood, fatty group
It knits, the mescenchymal stem cell (mesenchymal stem cells, abbreviation MSC) of pulp cavity, periodontal ligament or joint fluid.
The mucilage secretion is usually that will then do in culture medium appropriate by stem cell is isolated from tissue
Cell culture for a period of time, regathers supernatant and obtains.For example, mucilage secretion is being obtained by dental pulp mescenchymal stem cell
Concrete example in, first by surgical operation obtain pulp tissue, then use collagenase digestion myeloid tissue, will be centrifuged
The cell mass being precipitated out afterwards is cleaned using phosphate buffer, then cell is placed in culture medium and cultivates and removes
Other cells are to collect mescenchymal stem cell.Collected mescenchymal stem cell is then incubated at the culture without cow's serum
In base, 24 to 48 hours are lasted.After centrifugation or filtering removal cell and solid impurity, between collected supernatant is
The mucilage secretion of mesenchymal stem cells.Researchs many at present by mescenchymal stem cell it has been found that be derived extracellular
Secretion, which contains, can promote cytothesis and immunoregulatory activity victory peptide.It can be further by above-mentioned containing active victory peptide
Mucilage secretion is purified.These means of purification and operating condition are to have usually to know in the utility model technical field
Known to the knowledgeable, these means include but is not limited to filter, saltout, extracting, dialysing, size difference chromatography, hydrophobic reciprocation
Chromatography, ion-exchange chromatography and affinity chromatography.Therefore, the victory of Stem Cell Activity alleged by this case peptide powder can show substantially
Single kind of pure matter victory peptide, the mixture being made of a variety of victory peptides, through isolated peptide fraction (fractions) containing victory in part,
The peptide containing victory slightly extracts the forms such as object and combinations thereof.Depending on this case Stem Cell Activity victory peptide medicament is intended to manufactured dosage form,
Above-mentioned stem cell secretion object or its purified product can be in liquid form, can also make further across freeze-drying processing procedure is commonly used
It is made for freeze-dried powder (lyophilized powder) form.
Stem Cell Activity victory peptide powder or its metabolite can be shown on medicine or nutrition for receiving in this case
The advantageous activity of individual." individual " referred to herein is intended to cover the mankind or non-human vertebrate, such as non-human lactation
Animal.Non-human mammal includes livestock animals, companion animals, laboratory animal and non-human primate.Non-human
Body also includes but not limited to horse, ox, pig, goat, dog, cat, mouse, rat, guinea pig, gerbil jird, hamster, mink, rabbit and fish.Compared with
Good person be the mankind, especially with specified disease and need to give Stem Cell Activity victory peptide as therapeutic agent, auxiliary sex pill or
The human patients of nutriment, or be to be suitable for administering to Stem Cell Activity victory peptide to take good care of one's health, prevent disease or Replacement Battalion
Feeding healthy human.For example, this case Stem Cell Activity victory peptide powder can be applied to improve the symptom of specified disease, for
It causes a succession of biological respinse of specified disease to carry out inhibiting effect in vivo, or is enhancing or adjusting body immune response, to reach
To the plysiochemical process for reducing virulence factor, blocking reaction of causing a disease, neutralizing morbid substance, to generate mitigation, mitigate or disappear
Except the effect of disease.
It is generally also selectively blended in Stem Cell Activity victory peptide medicament in this case acceptable in pharmacy or nutrition
Excipient, interfacial agent, disintegrating agent, adhesive, diluent, lubricant, stabilization agent, antioxidant, corrigent, sweetener,
The adjuvants such as coloring agent, sorbefacient, plasticizer." being subjected in pharmacy or nutrition " referred to herein means these adjuvants
Do not have toxicity, irritation, Pyrogenicity, antigenic and hemolytic, and unsubstantial pharmacological activity for the individual given,
It will not interfere the performance of the beneficial effect of Stem Cell Activity victory peptide powder.These adjuvants are all the affiliated technology neck of the utility model
Have usually intellectual in domain to be familiar with.For example, the excipient can be selected from maltodextrin, colloidal silica
Silicon, starch, starch syrup and alpha-lactose.The diluent can selected from lactose, starch, mannitol, sorbierite, glucose,
Tricalcium phosphate, calcium phosphate, hypromellose, hypromellose acetic acid stearate, sucrose, calcium sulfate two are hydrated
Object, calcium lactate trihydrate, glycine, kaolin etc..The lubricant can be selected from stearic acid, calcium hydroxide, talcum, hard
Aliphatic radical fumaric acid sodium, hydrogenated vegetable oil, higher aliphatic acid and its alkali metal and alkali salt, glycerol, talcum, wax, boron
Acid, sodium benzoate, sodium acetate, sodium chloride, white amino acid, polyethylene glycol, methoxy poly (ethylene glycol), enuatrol, sodium benzoate, positive twenty
Dioxane acid glycerol base ester, NaLS, colloidal silicon dioxide, cornstarch etc..
Stem Cell Activity victory peptide medicament is loaded in container and is used for larynx sprayer by this case, not only for victory peptides activity
Ingredient provides adequately protection, and takes into account the high-transmission efficiency of victory peptide active component, and compared to other dosing ways, via
Schneiderian membrance dispensing can directly penetrate into capilary and enter systemic circulation and unite, and without intestines and stomach, thus be avoided intestines and stomach
Internal environment and ferment have quickly absorption, high bioavailability and the advantages such as effect quickly occur for winning the destruction of peptide.
Claims (6)
1. a kind of larynx sprayer for filling Stem Cell Activity victory peptide medicament, which is characterized in that include at least:
One pressing body, the socket pipe with a hollow framework, internal and one sparge pipe of landscape configuration, one end of the sparge pipe
It is at right angles bent to form one first spurt hole towards the lower section portion of the pressing body, the other end of the sparge pipe then extends to the socket pipe
Outer peripheral surface, and be laterally equipped with one and protrude from elongated nozzle outside pressing body, which is then formed with one
Two spurt holes；
One fixing sleeve, the pressing body is accepted in a cover mouth upwards by upper section portion, and center sets a perforative perforation for the sparge pipe
One end place wherein；
One container, corresponding fitting are fixed on the lower section portion of the fixing sleeve, and Stem Cell Activity victory peptide medicament is filled in the container；With
And
One pressure-applying unit, is installed at the perforation of the fixing sleeve, draws suction pipe part equipped with one, this draws suction pipe part one end and penetrates with the appearance
Device bottom, the other end are then exposed to the running-on of the fixing sleeve, and are removably connected to one end of the sparge pipe, this draws suction
Pipe fitting can by the socket pipe control and draw the Stem Cell Activity in the container victory peptide medicament with by the nozzle atomization
It sprays.
2. as described in claim 1 for the larynx sprayer of filling Stem Cell Activity victory peptide medicament, which is characterized in that the pressurization
The suction pipe part that draws of component draws suction pipe, containing tube and suction pipe configured with one, this, which draws suction pipe bottom end and wears one first spring, is followed by setting
One compression bar of group is worn in one taper sheath, the taper sheath bottom, which is arranged a second spring, second spring another end setting one
Ball, the containing tube is for drawing suction pipe, the first spring, taper sheath, compression bar, second spring and ball from top to bottom sequentially for above-mentioned
It is placed in pipe, and is socketed on the suction pipe in the containing tube bottom end.
3. as claimed in claim 2 for the larynx sprayer of filling Stem Cell Activity victory peptide medicament, which is characterized in that this draws suction
Pipe upper section portion protrudes from the running-on in the fixing sleeve upper section portion.
4. as claimed in claim 3 for the larynx sprayer of filling Stem Cell Activity victory peptide medicament, which is characterized in that this is fixed
Set is installed with a protection cap, which covers this and draw suction pipe.
5. as claimed in claim 3 for the larynx sprayer of filling Stem Cell Activity victory peptide medicament, which is characterized in that the hydrojet
The internal diameter of pipe is greater than this and draws the outer diameter of suction pipe.
6. as claimed in claim 3 for the larynx sprayer of filling Stem Cell Activity victory peptide medicament, which is characterized in that this draws suction
The internal diameter of pipe is greater than the outer diameter of the sparge pipe.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| TW106208997U TWM553196U (en) | 2017-06-21 | 2017-06-21 | Throat atomizer for filling with stem cell bioactive peptide drug |
| TW106208997 | 2017-06-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN209004926U true CN209004926U (en) | 2019-06-21 |
Family
ID=61229240
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721888089.5U Active CN209004926U (en) | 2017-06-21 | 2017-12-28 | Throat sprayer for filling stem cell active peptide medicament |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN209004926U (en) |
| DE (1) | DE202018100276U1 (en) |
| TW (1) | TWM553196U (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11944742B1 (en) * | 2023-06-08 | 2024-04-02 | Microneb Tech Holdings, Inc. | Apparatus, methods, and systems for administering a medication to an animal |
-
2017
- 2017-06-21 TW TW106208997U patent/TWM553196U/en not_active IP Right Cessation
- 2017-12-28 CN CN201721888089.5U patent/CN209004926U/en active Active
-
2018
- 2018-01-18 DE DE202018100276.7U patent/DE202018100276U1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| TWM553196U (en) | 2017-12-21 |
| DE202018100276U1 (en) | 2018-02-14 |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20230104 Address after: 15 / F, 8 / F, No. 10, Section 1, Chongqing South Road, Zhongzheng District, Taibei City, Taiwan, China Patentee after: You'an Cell Biomedical Technology Co.,Ltd. Address before: No. 8, 214 Lane, Section 2, East Nanjing Road, Zhongshan District, Taipei City, Taiwan, China Patentee before: Caire Medical-Biotechnology International Co. |