CN208902471U - Sampler is used in a kind of synthesis of impurity of the drug - Google Patents

Abstract

The utility model discloses a kind of impurity of the drug synthesis samplers, including sampling cylinder, it is embedded before the sampling cylinder and observation window is installed, dial markings are printed on the observation window, the sampling cylinder bottom surface is fixed with inlet tube, the sampling cylinder top surface is fixed with lifting assembly, and the lifting assembly side is fixed with handle；The lifting assembly includes pull rod and protective shell, and the pull rod top is fixed with handle, and the pull rod bottom end is fixed with tube plug, and the tube plug edge is bonded with the sampling cylinder inboard wall, offers mounting groove in the middle part of the pull rod, is provided with pressure spring in the mounting groove.Beneficial effect is: the utility model is risen in sampler barrel body by handle drive tube plug to be sucked the sample into and is caught in mode self-locking between block by guide wheel to prevent tube plug from declining naturally and splash out sample, avoid the problem of single sampling amount is not achieved using requirement, it is sampled without being repeated several times, reduces the workload of operator.

Description

Sampler is used in a kind of synthesis of impurity of the drug

Technical field

The utility model relates to impurity of the drug to synthesize accessory part field, and in particular to a kind of impurity of the drug synthesis sampling Device.

Background technique

The impurity of drug refers to stability, the curative effect present in drug without therapeutic effect or influence drug, or even right The harmful substance of health of human body.The research of drug, production, storage and in terms of, it is necessary to keep the pure of drug Degree, reduces the impurity of drug, just can guarantee the validity and safety of drug in this way, with the development of medical technology, drug is miscellaneous Matter is applied to synthesize new drug, and it is anti-to need for impurity of the drug to be placed in progress in reactor in impurity of the drug synthesis process It answers, often requires to use sampler during the reaction to sample the extent of reaction for checking impurity of the drug.

Applicants have discovered that at least there is following technical problem in the prior art: sampler has been sampled being put into reactor Easily sample is splashed out during at rear taking-up and the sample size taken out is caused to be not achieved using requirement, and sampling is repeated several times The workload of operator can directly be increased.

Utility model content

The purpose of this utility model is that solve the above-mentioned problems and provides a kind of impurity of the drug synthesis sampling dress It sets, easily sample is splashed out during being taken out after the completion of being put into reactor sampling and is led to solve sampler in the prior art The sample size taken out is caused to be not achieved using technical problems such as requirements.It is preferred in many technical solutions provided by the utility model Technical solution includes to rise in sampler barrel body by handle drive tube plug and sucks the sample into and be caught between block by guide wheel Self-locking mode splashes out sample to prevent tube plug from declining naturally, avoids single sampling amount and asking using requirement is not achieved The technical effects such as topic, elaboration as detailed below.

To achieve the above object, the utility model provides following technical scheme:

A kind of impurity of the drug synthesis sampler provided by the utility model, including sampling cylinder, the sampling cylinder Front is embedded to be equipped with observation window, and dial markings are printed on the observation window, and the sampling cylinder bottom surface is fixed with inlet tube, The sampling cylinder top surface is fixed with lifting assembly, and the lifting assembly side is fixed with handle；

The lifting assembly includes pull rod and protective shell, and the pull rod top is fixed with handle, and the pull rod bottom end is fixed There is tube plug, and the tube plug edge is bonded with the sampling cylinder inboard wall, offers mounting groove, the installation in the middle part of the pull rod Pressure spring is provided in slot, the pressure spring both ends are fixed with wheel carrier by grab, are provided with pin shaft on the inside of the wheel carrier outer end, described Guide wheel is provided on pin shaft, the protective shell is fixedly mounted on the sampling cylinder top surface, is arranged on the protective shell inner sidewall There are multiple blocks, the block is uniformly distributed, the outer rim of the block and the guide wheel EDGE CONTACT, and between the block Gap is not less than the radius of the guide wheel, and the protective shell bottom surface is fixed with guide sleeve, and the guide sleeve is coaxially set with the pull rod It sets.

Using a kind of above-mentioned impurity of the drug synthesis sampler, the reaction to the impurity of the drug reacted in reactor is needed Progress is sampled when checking, holds the handle and the sampling cylinder is driven to be moved to reactor and protrude into the inlet tube Under liquid level in reactor, the handle is held afterwards, the pull rod is driven to rise, the pull rod drives the tube plug to take described Rise in sample cylinder, since the edge of the tube plug is bonded with the inner wall of the sampling cylinder, so that the tube plug is in rising It can complete to sample due to generating negative pressure in the sampler barrel body and sucking impurity of the drug solution in the process, in the process of sampling In, it drives the guide wheel to roll at the edge of the block by the wheel carrier during the pull rod rising, is led when described Wheel is when rolling across the highest point of the block, the pressure spring discharge itself compression travel by the guide wheel be caught in the block it Between, keep the tube plug to exist so as to when sampling and completing by the guide wheel be caught in mode self-locking between the block The intracorporal position height of sampler barrel, and then prevent the intracorporal sample of the sampler barrel from splashing out naturally, avoid single sampling The problem of amount is not achieved using requirement, can check understanding by the dial markings on the observation window after the completion of sampling Single sampling amount.

Preferably, the material of the observation window is transparent glass, the scale division value of the dial markings is 1ml.

Preferably, the inlet tube and the sampling cylinder are coaxially disposed, the handle is flexible material.

Preferably, the handle is solid annular structure, the mounting groove is through slot, the mounting groove and the pressure spring Clearance fit.

Preferably, the compression travel of the pressure spring is not less than the profile elevations h of the guide wheel.

Preferably, the guide wheel exists in pairs, the guide wheel and the wheel carrier are riveted by the pin shaft activity.

Preferably, coating lubricating grease, the guide sleeve and the pull rod clearance fit in the guide sleeve.

Beneficial effect is: the utility model drives tube plug to rise in sampler barrel body and sucks the sample into and lead to by handle Crossing guide wheel and being caught in mode self-locking between block splashes out sample to prevent tube plug from declining naturally, avoids single sampling amount and reaches The problem of less than requirement is used, reduces the workload of operator it is not necessary that sampling is repeated several times.

Detailed description of the invention

In order to illustrate the embodiment of the utility model or the technical proposal in the existing technology more clearly, below will be to embodiment Or attached drawing needed to be used in the description of the prior art is briefly described, it should be apparent that, the accompanying drawings in the following description is only It is some embodiments of the utility model, for those of ordinary skill in the art, in the premise not made the creative labor Under, it is also possible to obtain other drawings based on these drawings.

Fig. 1 is that the utility model faces exterior view；

Fig. 2 is that the utility model faces interior view；

Fig. 3 is the vertical view exterior view of the utility model.

The reference numerals are as follows:

1, cylinder is sampled；101, handle；102, observation window；103, inlet tube；104, dial markings；2, lifting assembly； 201, handle；202, pull rod；203, protective shell；204, block；205, guide wheel；206, pin shaft；207, wheel carrier；208, guide sleeve； 209, tube plug；2010, mounting groove；2011, pressure spring.

Specific embodiment

To keep the purpose of this utility model, technical solution and advantage clearer, below by the technology to the utility model Scheme is described in detail.Obviously, the described embodiments are only a part of the embodiments of the utility model, rather than all Embodiment.Based on the embodiments of the present invention, those of ordinary skill in the art are not before making creative work Obtained all other embodiment is put, the range that the utility model is protected is belonged to.

Shown in referring to figures 1-3, the utility model provides a kind of impurity of the drug synthesis sampler, including sampler barrel Body 1, samples to embed before cylinder 1 and is equipped with observation window 102, is printed with dial markings 104 on observation window 102, samples 1 bottom of cylinder Face is fixed with inlet tube 103, and sampling 1 top surface of cylinder is fixed with lifting assembly 2, and 2 side of lifting assembly is fixed with handle 101；

Lifting assembly 2 includes pull rod 202 and protective shell 203, and 202 top of pull rod is fixed with handle 201,202 bottom end of pull rod It is fixed with tube plug 209, and 209 edge of tube plug is bonded with sampling 1 inner wall of cylinder, and mounting groove 2010 is offered in the middle part of pull rod 202, is pacified Pressure spring 2011 is provided in tankage 2010,2011 both ends of pressure spring are fixed with wheel carrier 207 by grab, set on the inside of 207 outer end of wheel carrier It is equipped with pin shaft 206, guide wheel 205 is provided on pin shaft 206, protective shell 203 is fixedly mounted on sampling 1 top surface of cylinder, protective shell 203 Multiple blocks 204 are provided on inner sidewall, block 204 is uniformly distributed, the outer rim and 205 EDGE CONTACT of guide wheel of block 204, and is kept off Gap between block 204 is not less than the radius of guide wheel 205, and 203 bottom surface of protective shell is fixed with guide sleeve 208, and guide sleeve 208 and pull rod 202 coaxial arrangements.

Preferably, the material of observation window 102 is transparent glass, the scale division value of dial markings 104 is 1ml, so set, Convenient for checking single sampling amount by observation window 102 and dial markings 104.

Inlet tube 103 and sampling cylinder 1 are coaxially disposed, so set, smoothly enter in sampling cylinder 1 convenient for sample, Handle 101 is flexible material, so set, convenient for having good sense of touch when hand-held handle 101.

Handle 201 is solid annular structure, so set, mounting groove 2010 is logical convenient for exerting a force when hand-held handle 201 Slot, mounting groove 2010 and 2011 clearance fit of pressure spring, so set, being convenient for the free extension in mounting groove 2010 of pressure spring 2011.

The compression travel of pressure spring 2011 is not less than the profile elevations h of guide wheel 205, so set, can lead to convenient for guide wheel 205 Cross the highest point of block 204.

Guide wheel 205 exists in pairs, and guide wheel 205 and wheel carrier 207 are riveted by 206 activity of pin shaft, so set, being convenient for guide wheel 205 freely roll at 207 edge of wheel carrier.

Lubricating grease, guide sleeve 208 and 202 clearance fit of pull rod are coated in guide sleeve 208, so set, leading convenient for pull rod 202 Smooth lifting under the guidance of set 208.

Using the above structure, when needing the extent of reaction to the impurity of the drug reacted in reactor to be sampled to check, hand Holding handle 101 drives sampling cylinder 1 to be moved to reactor and protrude into inlet tube 103 under the liquid level in reactor, holds hand afterwards Handle 201 drive pull rod 202 rise, pull rod 202 drive tube plug 209 sampling cylinder 1 in rise, due to tube plug 209 edge with The inner wall fitting of cylinder 1 is sampled, so that tube plug 209 can be due to generating negative pressure in sampling cylinder 1 and by medicine during rising Object dirt solution sucks to complete to sample, and during sampling, pull rod 202 is led during rising by the drive of wheel carrier 207 Wheel 205 rolls at the edge of block 204, and when guide wheel 205 rolls across the highest point of block 204, pressure spring 2011 discharges the pressure of itself Guide wheel 205 is caught between block 204 by indention journey, so as to be caught between block 204 when sampling and completing by guide wheel 205 Self-locking mode keeps position height of the tube plug 209 in sampling cylinder 1, and then prevents the sample in sampling cylinder 1 natural It splashes out, avoids the problem of single sampling amount is not achieved using requirement, the scale on observation window 102 can be passed through after the completion of sampling Graticule 104 understands single sampling amount to check.

Above description is only a specific implementation of the present invention, but the protection scope of the utility model is not limited to In this, anyone skilled in the art within the technical scope disclosed by the utility model, can readily occur in variation Or replacement, it should be covered within the scope of the utility model.Therefore, the protection scope of the utility model should be with the power Subject to the protection scope that benefit requires.

Claims (7)

1. a kind of impurity of the drug synthesis sampler, including sampling cylinder (1), it is characterised in that: before the sampling cylinder (1) Face is embedded to be equipped with observation window (102), is printed with dial markings (104) on the observation window (102), the sampling cylinder (1) Bottom surface is fixed with inlet tube (103), and sampling cylinder (1) top surface is fixed with lifting assembly (2), lifting assembly (2) side Face is fixed with handle (101)；

The lifting assembly (2) includes pull rod (202) and protective shell (203), and pull rod (202) top is fixed with handle (201), pull rod (202) bottom end is fixed with tube plug (209), and in the tube plug (209) edge and the sampling cylinder (1) Wall fitting, pull rod (202) middle part offer mounting groove (2010), are provided with pressure spring in the mounting groove (2010) (2011), pressure spring (2011) both ends are fixed with wheel carrier (207) by grab, are provided on the inside of wheel carrier (207) outer end Pin shaft (206) is provided with guide wheel (205) on the pin shaft (206), and the protective shell (203) is fixedly mounted on the sampler barrel Body (1) top surface is provided with multiple blocks (204) on protective shell (203) inner sidewall, and the block (204) is uniformly distributed, institute The outer rim and the guide wheel (205) EDGE CONTACT of block (204) are stated, and the gap between the block (204) is not less than described The radius of guide wheel (205), protective shell (203) bottom surface are fixed with guide sleeve (208), and the guide sleeve (208) and the pull rod (202) it is coaxially disposed.

2. a kind of impurity of the drug synthesis sampler according to claim 1, it is characterised in that: the observation window (102) Material be transparent glass, the scale division values of the dial markings (104) is 1ml.

3. a kind of impurity of the drug synthesis sampler according to claim 1, it is characterised in that: the inlet tube (103) It is coaxially disposed with the sampling cylinder (1), the handle (101) is flexible material.

4. a kind of impurity of the drug synthesis sampler according to claim 1, it is characterised in that: the handle (201) is Solid annular structure, the mounting groove (2010) are through slot, the mounting groove (2010) and the pressure spring (2011) clearance fit.

5. a kind of impurity of the drug synthesis sampler according to claim 1, it is characterised in that: the pressure spring (2011) Compression travel is not less than the profile elevations h of the guide wheel (205).

6. a kind of impurity of the drug synthesis sampler according to claim 1, it is characterised in that: the guide wheel (205) at To presence, the guide wheel (205) and the wheel carrier (207) are riveted by the pin shaft (206) activity.

7. a kind of impurity of the drug synthesis sampler according to claim 1, it is characterised in that: in the guide sleeve (208) Coat lubricating grease, the guide sleeve (208) and the pull rod (202) clearance fit.