CN208857288U - A kind of chicken cell factor immunologic adjuvant preparation desktop type minicell crusher - Google Patents

Abstract

The utility model relates to biomixer fields, in particular to a kind of chicken cell factor immunologic adjuvant preparation desktop type minicell crusher, rack-mount pressurized equipment including bracket and from top to down, pan feeding cavity, high-pressure chamber, V-type convection current jet pipe, recycle cavity, the outer sheath of high-pressure chamber is equipped with water cooling equipment, the bottom end of pan feeding cavity is provided with the discharge port for being communicated to high-pressure chamber, high-pressure chamber includes the tubular housing for being mounted on pan feeding cavity bottom end and being connected to discharge port, the bottom of tubular housing is equipped with the hydraulic valve being tucked into inside tubular housing, V-type convection current jet pipe includes the V-type convection duct that tubular housing exit is arranged in and is blocked by hydraulic valve, V-type convection duct extends then downward and extends towards away from the two sides of tubular housing, the equipment volume is small, it is at low cost, cooling effect It is good, it can be placed on desktop, and can repeatedly be worked with automatic cycle so that the cell in liquid is fully crushed.

Description

A kind of chicken cell factor immunologic adjuvant preparation desktop type minicell crusher

Technical field

The utility model relates to biomixer field, in particular to a kind of chicken cell factor immunologic adjuvant standby desktop Type minicell crusher.

Background technique

The prevention and treatment of chicken viral diseases mainly uses drug therapy and vaccine immunity at present.Drug therapy mainly uses antibiosis Element, but extensive a large amount of uses of antibiotic cause endurance strain largely to generate in recent years, and are transmitted to people by food chain, into And bigger threat is brought to human health.Some antibiotic and antibacterial agent are prohibited since 16 years in aquaculture in China Application.And vaccine immunity is since the serotype of virus is complicated, strain variation is fast, often results in vaccine immunity failure.Using cell Factor immunologic adjuvant combined vaccine use can significantly increase immune effect of vaccine.The preparation process of chicken cell factor immunologic adjuvant It needs to carry out cellular lysate to the engineering bacteria in fermentation liquid, it is therefore desirable to a kind of biomixer.

Chinese patent CN105925472B discloses a kind of industrial super-pressure method of cell disruption, first by cell to be broken Volume two-stage swell, then using void effect and shearing effect by clasmatosis, hence it is evident that the volume to swell can aggravate hole The crushing effect of effect and shearing effect, obtains void effect more direct than cell and shearing effect is crushed better crushing effect, Crush the cell tissue in biological medicine raw material, 97% or more reach 100nm hereinafter, and target composition granule it is uniform, be convenient for Further extraction and purifying；A large amount of chemical reagent can be saved, industrial pollution is reduced；Greatly improve the utilization of medical material Rate.The invention also discloses a kind of industrial super-pressure biomixer, including bracket, bidirectional hydraulic oil cylinder, super-pressure cavity, Recycle cavity, check-valves, at least one outlet valve, feed hopper, Pneumatic oil pump, fuel tank and two four-way electromagnetic reversing valves.

Equipment disclosed in this method is excessively huge, is unfavorable for laboratory use, needs a kind of can put on the table Minicell crusher.

Utility model content

The purpose of this utility model is that in view of the deficiencies of the prior art, providing a kind of chicken cell factor immunologic adjuvant preparation With desktop type minicell crusher, the equipment volume is small, at low cost, good cooling results, can be placed on desktop, and can be with Automatic cycle repeatedly works so that the cell in liquid is fully crushed.

To solve the above problems, the utility model the following technical schemes are provided:

A kind of chicken cell factor immunologic adjuvant preparation desktop type minicell crusher, including bracket and from top to down Rack-mount pressurized equipment, pan feeding cavity, high-pressure chamber, V-type convection current jet pipe, recycling cavity, the outside of high-pressure chamber It is arranged with water cooling equipment, pressurized equipment includes to be mounted on the hydraulic cylinder of cantilever tip and be fixedly mounted on hydraulic cylinder output end First plunger, the bottom end of pan feeding cavity are provided with the discharge port for being communicated to high-pressure chamber, and the side of pan feeding cavity, which is provided with, to be run through Pan feeding chamber outer wall and the feeding pipe for extending into pan feeding inside cavity, the input terminal of feeding pipe are equipped with material bin, the first plunger The surface of discharge port is set straight down, and high-pressure chamber includes the pipe for being mounted on pan feeding cavity bottom end and being connected to discharge port Shape cavity, the bottom of tubular housing are equipped with the hydraulic valve being tucked into inside tubular housing, and V-type convection current jet pipe includes that setting exists Tubular housing exit and the V-type convection duct blocked by hydraulic valve, two sides of the V-type convection duct away from tubular housing Extend then downward and extend towards, the bottom end for recycling cavity is provided with liquid outlet, and the output end of liquid outlet is equipped with valve.

Pan feeding cavity side is provided with the outer wall through pan feeding cavity and extend into the feed back pipe of pan feeding inside cavity, recycling The bottom end of cavity is provided with feedback outlet, and the output end of feedback outlet is equipped with feed back pump, and the output end of feed back pump is equipped with and feed back The feed back pipe of pipe connection.

Hydraulic valve includes the second plunger filled in inside tubular housing and the hydraulic spring grease cup that is mounted on the second plunger base.

The output end of V-type convection duct is provided with the Lavalle spray head being connected to recycling cavity, and Lavalle spray head is V-shaped right Claim setting.

Water cooling equipment includes the fluid jet nozzle for being set in tubular housing top and the opening that is set in tubular housing bottom end Water pot, opening water pot side are provided with through opening water pot and extend to the liquid back pipe inside opening water pot, install on liquid back pipe There is time liquid pump for being communicated to fluid jet nozzle.

Fluid jet nozzle includes the outer cylinder being set on the outside of tubular housing, the inner wall of outer cylinder and the outer wall of tubular housing Ring-shaped cavity is constituted, be provided on the outside of outer cylinder through outer cylinder and extend into the liquid-in pipe inside ring-shaped cavity, enters liquid It manages and is connected to the output end for returning liquid pump, the bottom end of outer cylinder extends downwards and towards the direction of tubular housing, so that outer cylinder Bottom end inner wall and tubular housing outer wall between form narrow cyclic annular jet port.

The utility model has the advantages that liquid is entered in feeding pipe by material bin and is flowed into tubular housing by discharge port, liquid Cylinder pressure presses to the liquid in tubular housing by the first plunger, and liquid is pressurized in tubular housing and presses to hydraulic valve, makes The second plunger of liquid heats obtained in tubular housing is mobile towards the direction of compression hydraulic spring, when the second plunger is moved to tubulose After the outside of cavity, the output end that the liquid in tubular housing passes through tubular housing at once is spouting, at this time pressurized equipment Continue to be pressurized, so that the liquid in tubular housing is flowed into V-type convection duct with stable pressure and flow velocity, liquid passes through V Type convection duct is simultaneously spouting eventually by Lavalle spray head, change of the speed because spraying sectional area when liquid passes through Lavalle spray head Change and change, Laval nozzle can make gas from subsonic speed to velocity of sound, until supersonic speed is accelerated to, so Lavalle spray head The speed that liquid sprays in opposite directions in V-type convection duct can be greatly increased, so that liquid at high speed V-type is collided and caused in liquid Cell because collision and be crushed, but finally flow out tubular housing liquid in V-type convection duct due to losing pressure, nothing Method high velocity impact, so needing to be repeated several times collision so that the cell in liquid is all broken, being pumped by feed back will be in feedback outlet The liquid of outflow is input in pan feeding cavity by feed back pipe, and then pressurization is clashed several times repeatedly again, since pressurized equipment is to height A large amount of heat can be generated when pressure cavity pressurization, the cell that may result in liquid is rotten, so needing water cooling equipment to height Cavity cooling is pressed, liquid pump is returned and is input to the water being open in water pot in ring-shaped cavity by liquid-in pipe, water passes through cyclic annular jet port It is spouting along the outer wall of tubular housing and generate wall attachment effect, so that the water flow high speed ejected by cyclic annular jet port The outer wall for being attached to tubular housing flows downward so that the water flow on tubular housing expeditiously simultaneously with tubular housing and atmosphere Exchange heat.

1. equipment volume is small, at low cost, can be placed on desktop；

2. the cell in liquid can be made fully to be crushed by multiple impacts after the liquid automatic circulation after collision；

3. the liquid that fluid jet nozzle sprays passes through wall attachment effect in the outside flow at high speed of high-pressure chamber, so that high-pressure chamber Temperature can be got off with rapid cooling.

Detailed description of the invention

Fig. 1 is the perspective view of the utility model；

Fig. 2 is the front view of the utility model；

Fig. 3 is the front section view of the utility model；

Fig. 4 is the three-dimensional cutaway view of the utility model；

Fig. 5 is enlarged drawing at the A of the utility model Fig. 3；

Fig. 6 is enlarged drawing at the B of the utility model Fig. 3；

Description of symbols: pressurized equipment 1, hydraulic cylinder 1a, the first plunger 1b, pan feeding cavity 2, feeding pipe 2a, material bin 2a1, feed back pipe 2b, discharge port 2c, high-pressure chamber 3, tubular housing 3a, hydraulic valve 3b, the second plunger 3b1, hydraulic spring grease cup 3b2, V Type convection current jet pipe 4, V-type convection duct 4a, Lavalle spray head 4b recycle cavity 5, liquid outlet 5a, valve 5b, and feedback outlet 5c is returned Material pump 5d, water cooling equipment 6, fluid jet nozzle 6a, outer cylinder 6a1, ring-shaped cavity 6a2, liquid-in pipe 6a3, cyclic annular jet port 6a4 are opened Saliva tank 6b, liquid back pipe 6b1 return liquid pump 6c, bracket 7.

Specific embodiment

With reference to the accompanying drawings of the specification and embodiment, specific embodiment of the utility model is described in further detail:

Referring to figs. 1 to a kind of chicken cell factor immunologic adjuvant preparation desktop type minicell crusher described in Fig. 6, packet Include bracket 7 and be mounted on bracket 7 from top to down pressurized equipment 1, pan feeding cavity 2, high-pressure chamber 3, V-type convection current jet pipe 4, Recycle cavity 5, the outer sheath of high-pressure chamber 3 is equipped with water cooling equipment 6, and pressurized equipment 1 includes be mounted on 7 top of bracket hydraulic Cylinder 1a and the first plunger 1b for being fixedly mounted on hydraulic cylinder 1a output end, the bottom end of pan feeding cavity 2, which is provided with, is communicated to high pressure chest The discharge port 2c of body 3, the side of pan feeding cavity 2 are provided with through 2 outer wall of pan feeding cavity and extend into entering inside pan feeding cavity 2 Expects pipe 2a, the input terminal of feeding pipe 2a are equipped with material bin 2a1, the first plunger 1b be arranged in straight down discharge port 2c just on Side, high-pressure chamber 3 includes the tubular housing 3a for being mounted on 2 bottom end of pan feeding cavity and being connected to discharge port 2c, tubular housing 3a's Bottom is equipped with the hydraulic valve 3b being tucked into inside tubular housing 3a, and V-type convection current jet pipe 4 includes that setting goes out in tubular housing 3a The V-type convection duct 4a blocked at mouthful and by hydraulic valve 3b, V-type convection duct 4a prolong away from the two sides of tubular housing 3a It stretches then downward and extends towards, the bottom end of recycling cavity 5 is provided with liquid outlet 5a, and the output end of liquid outlet 5a is equipped with valve 5b, liquid are entered in feeding pipe 2a by material bin 2a1 and are flowed into tubular housing 3a by discharge port 2c, hydraulic cylinder 1a It is pressed by the first plunger 1b to the liquid in tubular housing 3a, liquid is pressurized in tubular housing 3a and applies to hydraulic valve 3b Pressure, hydraulic valve 3b is passively opened after the liquid in tubular housing 3a reaches certain pressure, and liquid is flowed into from tubular housing 3a Into V-type convection duct 4a and at an angle opposite high velocity impact, so that the clasmatosis in liquid, broken thin Born of the same parents enter in recycling cavity 5 with liquid, and then opening valve 5b can be collected by liquid outlet 5a containing smudge cells Liquid.

The feed back pipe that 2 side of pan feeding cavity is provided with the outer wall through pan feeding cavity 2 and extend into inside pan feeding cavity 2 2b, the bottom end of recycling cavity 5 are provided with feedback outlet 5c, and the output end of feedback outlet 5c is equipped with feed back pump 5d, and feed back pumps the defeated of 5d Outlet is equipped with the feed back pipe being connected to feed back pipe 2b, and liquid flows out in tubular housing 3a and by V-type convection duct 4a high Speed collision, but the liquid of last outflow tubular housing 3a in V-type convection duct 4a due to losing pressure, can not touch at a high speed It hits, so needing to be repeated several times collision so that the cell in liquid is all broken, pumping 5d by feed back will flow out in feedback outlet 5c Liquid be input in pan feeding cavity 2 by feed back pipe 2b, then again repeatedly pressurization head-on collision several times.

Hydraulic valve 3b includes the second plunger 3b1 filled in inside tubular housing 3a and is mounted on the second bottom plunger 3b1 Hydraulic spring grease cup 3b2, pressurized equipment 1 is to the liquid pressurization in tubular housing 3a, so that liquid heats in tubular housing 3a the The direction of two plunger 3b1 towards compression hydraulic spring 3b2 are mobile, when the second plunger 3b1 be moved to tubular housing 3a outside it Afterwards, the liquid in tubular housing 3a pass through at once tubular housing 3a output end it is spouting, pressurized equipment 1 continues to increase at this time Pressure, so that the liquid in tubular housing 3a is flowed into V-type convection duct 4a with stable pressure and flow velocity.

The output end of V-type convection duct 4a is provided with the Lavalle spray head 4b, Lavalle spray head 4b being connected to recycling cavity 5 V-shaped to be symmetrical arranged, for liquid by speed when the spray head 4b of Lavalle because the variation of spray sectional area changes, Laval nozzle can be with So that gas is from subsonic speed to velocity of sound, until supersonic speed is accelerated to, so Lavalle spray head 4b can greatly increase V-type convection current The speed that liquid sprays in opposite directions in pipeline 4a, so that liquid at high speed V-type is collided.

Water cooling equipment 6 includes to be set in the fluid jet nozzle 6a on the top tubular housing 3a and be set in the bottom end tubular housing 3a Opening water pot 6b, opening the side water pot 6b be provided with through opening water pot 6b and extend to opening water pot 6b inside liquid back pipe Time liquid pump 6c for being communicated to fluid jet nozzle 6a is installed, the water being open in water pot 6b passes through liquid back pipe 6b1 on 6b1, liquid back pipe 6b1 It is entered in fluid jet nozzle 6a with liquid pump 6c is returned, then the outer along tubular housing 3a is spouting, and the liquid ejected is cold But it drops into opening water pot 6b and recycles after tubular housing 3a.

Fluid jet nozzle 6a includes the outer cylinder 6a1 being set on the outside of tubular housing 3a, the inner wall and tubulose of outer cylinder 6a1 The outer wall of cavity 3a constitutes ring-shaped cavity 6a2, is provided on the outside of outer cylinder 6a1 through outer cylinder 6a1 and extend into ring-type Liquid-in pipe 6a3 inside cavity 6a2, liquid-in pipe 6a3 are connected to the output end for returning liquid pump 6c, and the bottom end of outer cylinder 6a1 is downwards simultaneously And extend towards the direction of tubular housing 3a, so that being formed between the bottom end inner wall of outer cylinder 6a1 and the outer wall of tubular housing 3a Narrow cyclic annular jet port 6a4 returns liquid pump 6c for the water being open in water pot 6b and is input to ring-shaped cavity by liquid-in pipe 6a3 In 6a2, water is spouting along the outer wall of tubular housing 3a by ring-type jet port 6a4 and generates wall attachment effect, so that passing through The outer wall for being attached to tubular housing 3a for the water flow high speed that cyclic annular jet port 6a4 is ejected flows downward, so that tubular housing 3a On water flow expeditiously with tubular housing 3a and atmosphere exchange heat simultaneously.

Working principle: liquid is entered in feeding pipe 2a by material bin 2a1 and is flowed into tubular cavity by discharge port 2c In body 3a, hydraulic cylinder 1a presses to the liquid in tubular housing 3a by the first plunger 1b, and liquid is pressurized in tubular housing 3a And press to hydraulic valve 3b, so that liquid heats the second plunger 3b1 in tubular housing 3a is towards the side of compression hydraulic spring 3b2 To movement, after the second plunger 3b1 is moved to the outside of tubular housing 3a, the liquid in tubular housing 3a passes through tubulose at once The output end of cavity 3a is spouting, and pressurized equipment 1 continues to be pressurized at this time, so that the liquid in tubular housing 3a is smoothly to press Power and flow velocity are flowed into V-type convection duct 4a, and liquid is sprayed by V-type convection duct 4a and eventually by Lavalle spray head 4b And go out, for liquid by speed when the spray head 4b of Lavalle because the variation of spray sectional area changes, Laval nozzle can make gas From subsonic speed to velocity of sound, until supersonic speed is accelerated to, so Lavalle spray head 4b can be greatly increased in V-type convection duct 4a The speed that liquid sprays in opposite directions, so that liquid at high speed V-type collides and the cell in liquid is caused to be crushed because of collision, but last Flow out tubular housing 3a liquid in V-type convection duct 4a due to losing pressure, can not high velocity impact, so need repeatedly Collision several times pumps 5d by feed back and the liquid flowed out in feedback outlet 5c is passed through feed back pipe so that cell in liquid is all broken 2b is input in pan feeding cavity 2, and then pressurization is clashed several times repeatedly again, due to that can produce when pressurized equipment 1 pressurizes to high-pressure chamber 3 Raw a large amount of heat, the cell that may result in liquid is rotten, so water cooling equipment 6 is needed to cool down to high-pressure chamber 3, returns liquid The water being open in water pot 6b is input in ring-shaped cavity 6a2 by pump 6c by liquid-in pipe 6a3, and water passes through the ring-type edge jet port 6a4 Tubular housing 3a outer wall it is spouting and generate wall attachment effect so that high by the water flow that ring-type jet port 6a4 is ejected Speed the outer wall for being attached to tubular housing 3a flow downward so that the water flow on tubular housing 3a expeditiously simultaneously and tubular cavity Body 3a and atmosphere exchange heat.

The above descriptions are merely preferred embodiments of the present invention, not makees to the technical scope of the utility model Any restrictions out, thus it is any trickle amendment made by the above technical examples according to the technical essence of the present invention, equivalent Variation and modification, in the range of still falling within the technical solution of the utility model.

Claims (6)

1. a kind of chicken cell factor immunologic adjuvant preparation desktop type minicell crusher, it is characterised in that: including bracket (7) Pressurized equipment (1), pan feeding cavity (2), high-pressure chamber (3), the V-type convection current jet pipe being mounted on bracket (7) from top to down (4), cavity (5) are recycled, the outer sheath of high-pressure chamber (3) is equipped with water cooling equipment (6), and pressurized equipment (1) includes to be mounted on branch The hydraulic cylinder (1a) on frame (7) top and the first plunger (1b) for being fixedly mounted on hydraulic cylinder (1a) output end, pan feeding cavity (2) Bottom end is provided with the discharge port (2c) for being communicated to high-pressure chamber (3), and the side of pan feeding cavity (2) is provided with through pan feeding cavity (2) outer wall and it is extend into the internal feeding pipe (2a) of pan feeding cavity (2), the input terminal of feeding pipe (2a) is equipped with material bin (2a1), the first plunger (1b) are arranged in the surface of discharge port (2c) straight down, high-pressure chamber (3) include be mounted on into Material cavity (2) bottom end and the tubular housing (3a) for being connected to discharge port (2c), the bottom of tubular housing (3a), which is equipped with, is tucked into pipe The internal hydraulic valve (3b) of shape cavity (3a), V-type convection current jet pipe (4) include setting the tubular housing exit (3a) and by The V-type convection duct (4a) that hydraulic valve (3b) blocks, V-type convection duct (4a) extend away from the two sides of tubular housing (3a) Then downwards and extend towards, recycling cavity (5) bottom end be provided with liquid outlet (5a), the output end of liquid outlet (5a) is equipped with Valve (5b).

2. a kind of chicken cell factor immunologic adjuvant preparation desktop type minicell crusher according to claim 1, Be characterized in that: pan feeding cavity (2) side is provided with the outer wall through pan feeding cavity (2) and extend into pan feeding cavity (2) inside The bottom end of feed back pipe (2b), recycling cavity (5) is provided with feedback outlet (5c), and the output end of feedback outlet (5c) is equipped with feed back pump The output end of (5d), feed back pump (5d) are equipped with the feed back pipe being connected to feed back pipe (2b).

3. a kind of chicken cell factor immunologic adjuvant preparation desktop type minicell crusher according to claim 1, Be characterized in that: hydraulic valve (3b) includes to fill in internal the second plunger (3b1) of tubular housing (3a) and be mounted on the second plunger The hydraulic spring grease cup (3b2) of the bottom (3b1).

4. a kind of chicken cell factor immunologic adjuvant preparation desktop type minicell crusher according to claim 1, Be characterized in that: the output end of V-type convection duct (4a) is provided with the Lavalle spray head (4b) being connected to recycling cavity (5), Bearing score Your spray head (4b) is V-shaped to be symmetrical arranged.

5. a kind of chicken cell factor immunologic adjuvant preparation desktop type minicell crusher according to claim 1, Be characterized in that: water cooling equipment (6) includes to be set in the fluid jet nozzle (6a) on the top tubular housing (3a) and be set in tubular cavity The opening water pot (6b) of the bottom end body (3a), opening side water pot (6b) are provided with through opening water pot (6b) and extend to opening water The internal liquid back pipe (6b1) of tank (6b), be equipped on liquid back pipe (6b1) be communicated to fluid jet nozzle (6a) return liquid pump (6c).

6. a kind of chicken cell factor immunologic adjuvant preparation desktop type minicell crusher according to claim 5, Be characterized in that: fluid jet nozzle (6a) includes the outer cylinder (6a1) being set on the outside of tubular housing (3a), outer cylinder (6a1) The outer wall of inner wall and tubular housing (3a) constitute ring-shaped cavity (6a2), are provided on the outside of outer cylinder (6a1) through outer cylinder (6a1) and it is extend into the internal liquid-in pipe (6a3) of ring-shaped cavity (6a2), liquid-in pipe (6a3) connects with the output end for returning liquid pump (6c) Logical, the bottom end of outer cylinder (6a1) extends downwards and towards the direction of tubular housing (3a), so that the bottom end of outer cylinder (6a1) Narrow cyclic annular jet port (6a4) is formd between inner wall and the outer wall of tubular housing (3a).