CN208742526U - A kind of continuous reaction apparatus synthesizing Enrofloxacin - Google Patents

Abstract

The utility model discloses a kind of continuous reaction apparatus for synthesizing Enrofloxacin, it include reaction kettle, the lower part of the circumferential side wall of reaction kettle is equipped with the first transverse slat laterally extended outward, the downside of first transverse slat has one group of side plate symmetrically extended down, opposite side all has the groove of the lateral strip formed toward sunken inside between both side plate, it is parallel to each other between groove on both side plate, the leading flank of the first transverse slat is run through in wherein one end of groove；Perfusion tube is equipped in first transverse slat, perfusion tube is equipped with controlled valve, and one end of perfusion tube extends through the side wall of reaction kettle along the length direction of the first transverse slat and extends to the inside of reaction kettle；The other end of perfusion tube is bent down and runs through the lower wall of the first transverse slat；First transverse slat is also provided with the vertical hole location for being used to place rubber head dropper.Compared with prior art, the utility model can carry out composition detection under the premise of not interrupting reaction kettle successive reaction.

Description

A kind of continuous reaction apparatus synthesizing Enrofloxacin

Technical field

The utility model relates to Enrofloxacin manufacturing equipment field more particularly to a kind of successive reactions for synthesizing Enrofloxacin Device.

Background technique

Enrofloxacin is Comprecin, because it can inhibit DNA of bacteria helicase, has a broad antifungal spectrum, efficiently, low toxicity, Tissue penetration is strong, it has also become animal doctor, which faces, one of to be examined with anti-infectives most important in aquaculture, be largely used to treatment, Prevention and promotion growth.Enrofloxacin is usually using fluorine quinolinic acid and n-ethylpiperazine as initial synthetic, by condensation And a series of reaction synthesis.The reaction process carries out generally in reaction kettle, during synthesis, often generates Impurity, these impurity can be solvent, reagent, parent material, the by-product of reaction, reaction intermediate product and degradation product.Mesh The scheme of the impurity of preceding detection Enrofloxacin can generally take high-efficient liquid phase technique (HPLC) to generally require when using the program Acquire sample.Since Enrofloxacin is synthesized in reaction kettle, during Enrofloxacin synthesis or synthesize Cheng Shi must then stop the processing synthesis process of reaction kettle if necessary to carry out the detection of component content to it, and then from reaction The leakage fluid dram of kettle takes out sample to detect, and is finally detected.It is generally fixed and is connected with other containers due to the drain pipe of reaction kettle It connects, discharge process is typically all to be controlled by the controlled valve of drain pipe, therefore, when needs were reacted in Enrofloxacin Sample detection is carried out in journey, sampling is more difficult, and detection process is cumbersome, and increases process time.

Utility model content

The utility model is to solve existing technological deficiency, provides a kind of continuous reaction apparatus for synthesizing Enrofloxacin, It can carry out composition detection under the premise of not interrupting reaction kettle successive reaction.Its specific technical solution is as follows:

The utility model discloses a kind of continuous reaction apparatus for synthesizing Enrofloxacin, includes reaction kettle, the circle of reaction kettle The lower part of all side walls is equipped with the first transverse slat laterally extended outward, and the downside of the first transverse slat is symmetrical toward downward with one group The side plate stretched, opposite side all has the groove of the strip laterally formed toward sunken inside between both side plate, on both side plate Groove between be parallel to each other, the leading flank of the first transverse slat is run through in wherein one end of groove；Infusion is equipped in first transverse slat Pipe, perfusion tube are equipped with controlled valve, one end of perfusion tube extended through along the length direction of the first transverse slat reaction kettle side wall, And extend to the inside of reaction kettle；The other end of perfusion tube is bent down and runs through the lower wall of the first transverse slat；First transverse slat is also Offer the vertical hole location for being used to place rubber head dropper.

Further, the lower part of the circumferential side wall of reaction kettle is additionally provided with the second transverse slat laterally extended outward, the second transverse slat Below the first transverse slat, the second transverse slat is parallel with the first transverse slat.

Further, heating plate is inlaid with inside the second transverse slat.

Further, groove inner surface is equipped with and the downside of the first transverse slat is equipped with sealed bolster layer.

Further, reaction kettle is communicated with pneumatic tube.

The utility model has the beneficial effects that mouth rim is placed on first with the container of flange when acquiring sample It below transverse slat, and is held in the mouth flange of container on the groove of the first transverse slat, then need to only open opening on perfusion tube Closing valve can be taken off sample；The medicament of auxiliary detection is added in container from the hole location of the first transverse slat by rubber head dropper； Then the medicament in container is stirred from stirring rod from hole location, can finally be detected.The utility model can To be sampled detection under the premise of not stopping reaction process, sampling process is simple and convenient, saves process time.

Detailed description of the invention

Fig. 1 is the overall structure diagram of the utility model embodiment；

Fig. 2 is combination diagram between the container, rubber head dropper and reaction kettle three of the utility model embodiment；

Fig. 3 is the structural schematic diagram of the container of the utility model embodiment.

It is marked in figure: reaction kettle 100, pneumatic tube 101, the first transverse slat 200, hole location 201, side plate 202, groove 203, second Transverse slat 300, heating plate 301, perfusion tube 400, controlled valve 401, rubber head dropper 500, container 600.

Specific embodiment

The embodiments of the present invention are described below in detail, examples of the embodiments are shown in the accompanying drawings, wherein from beginning Same or similar element or element with the same or similar functions are indicated to same or similar label eventually.Below by ginseng The embodiment for examining attached drawing description is exemplary, it is intended to for explaining the utility model, and should not be understood as to the utility model Limitation.

The utility model is described in further detail below by specific embodiment combination attached drawing.Please refer to attached drawing.

The utility model discloses a kind of continuous reaction apparatus for synthesizing Enrofloxacin, includes reaction kettle 100, reaction kettle The lower part of 100 circumferential side wall is equipped with laterally the first transverse slat 200 for extending outward, is generally screwed installation, and first The surface of transverse slat 200 is coated with erosion shield；The downside of first transverse slat 200 has one group of side plate symmetrically extended down 202, opposite side all has the groove 203 of the strip laterally formed toward sunken inside, groove 203 between both side plate 202 Length direction be that (front-rear direction in attached drawing 1, the direction appeared below are all made of the orientation of attached drawing 1 as ginseng to front-rear direction Examine), it is parallel to each other between the groove 203 on both side plate 202, the front side of the first transverse slat 200 is run through in wherein one end of groove 203 It face only need to be container 600 along the longitudinal direction inside when oral area is limited to the first 200 lower section of transverse slat with the container 600 of flange It promotes, makes in the flange slide into grooves 203 of container 600；It is equipped with perfusion tube 400 in first transverse slat 200, perfusion tube 400 is set There is controlled valve 401, controlled valve 401 can use electrically operated valve or manually-operated gate, use manually-operated gate, hand in the present embodiment The control terminal of movable valve extends to the upper side of the first transverse slat 200.One end of perfusion tube 400 is along the length side of the first transverse slat 200 To the side wall for extending through reaction kettle 100 and extend to the inside of reaction kettle 100；The other end of perfusion tube 400 is bent down And run through the lower wall of the first transverse slat 200；First transverse slat 200 is also provided with the vertical hole location for being used to place rubber head dropper 500 201.When acquiring sample, mouth rim is placed on 200 lower section of the first transverse slat with the container 600 of flange, and make container 600 mouth flange is held on the groove 203 of the first transverse slat 200, then need to only open the controlled valve on perfusion tube 400 401, under gravity, solution is flowed to automatically in container 600；By rubber head dropper 500 from the hole location of the first transverse slat 200 The medicament of auxiliary detection is added at 201 in container 600；Then with stirring rod from hole location 201 to the medicament in container 600 into Row stirring, can finally be detected.The utility model can be sampled inspection under the premise of not stopping reaction process It surveys, sampling process is simple and convenient, saves process time.

Further, the lower part of the circumferential side wall of reaction kettle 100 is additionally provided with the second transverse slat 300 laterally extended outward, the One end of two transverse slats 300 is fixed by screws on the side wall of reaction kettle 100, and the surface of the second transverse slat 300 is coated with anticorrosion painting Layer；Second transverse slat 300 is located at 200 lower section of the first transverse slat, and the second transverse slat 300 is parallel with the first transverse slat 200, and the second transverse slat 300 can To carry to container 600, and then it is limited to container 600 more stably between the first transverse slat 200 and the second transverse slat 300； When needing to detect, container 600 can be taken and mobile container 600 is detected or may not need at instrument, instrument is consolidated Surely it is integrated on the circumferential side wall of reaction kettle 100, directly the solution in container 600 is detected using instrument.

Further, heating plate 301 is inlaid with inside the second transverse slat 300, heating plate 301 generally uses nichrome system At；The effect of heating plate 301 is to control solution temperature for heating to the solution in container 600.

Further, 203 inner surface of groove is equipped with and the downside of the first transverse slat 200 is equipped with sealed bolster layer, close Envelope cushion course can be made of silica gel or rubber, and sealed bolster layer can be sealed 600 mouthfuls of container, prevent container 600 Interior solution is contaminated；Sealed bolster layer can also prevent the downside of the first transverse slat 200 and groove 203 from being corroded.

Further, reaction kettle 100 is communicated with pneumatic tube 101, when the drain side port of perfusion tube 400 is lower than reaction kettle When liquid level in 100, the air pressure in reaction kettle 100 can be increased by pneumatic tube 101, and then make solution from 400 row of perfusion tube Out.

The above content is combine specific embodiment further detailed description of the utility model, and it cannot be said that The specific implementation of the utility model is only limited to these instructions.For the utility model person of an ordinary skill in the technical field For, without departing from the concept of the premise utility, a number of simple deductions or replacements can also be made.

Claims (5)

1. a kind of continuous reaction apparatus for synthesizing Enrofloxacin, includes reaction kettle (100), the circumference of the reaction kettle (100) The lower part of side wall is equipped with the first transverse slat (200) laterally extended outward, and the downside of first transverse slat (200) has one group The symmetrically side plate (202) that extends down, opposite side all has the laterally shape toward sunken inside between two side plates (202) At strip groove (203), be parallel to each other between the groove (203) on two side plates (202), the groove (203) leading flank of first transverse slat (200) is run through in wherein one end；Infusion is equipped in first transverse slat (200) It manages (400), the perfusion tube (400) is equipped with controlled valve (401), and one end of the perfusion tube (400) is along first transverse slat (200) length direction extends through the side wall of the reaction kettle (100) and extends to the inside of the reaction kettle (100)； The other end of the perfusion tube (400) is bent down and runs through the lower wall of first transverse slat (200)；First transverse slat (200) it is also provided with the vertical hole location (201) for being used to place rubber head dropper (500).

2. continuous reaction apparatus as described in claim 1, which is characterized in that under the circumferential side wall of the reaction kettle (100) Portion is additionally provided with the second transverse slat (300) laterally extended outward, and second transverse slat (300) is located under first transverse slat (200) Side, second transverse slat (300) are parallel with the first transverse slat (200).

3. continuous reaction apparatus as claimed in claim 2, which is characterized in that be inlaid with and add inside second transverse slat (300) Hot plate (301).

4. continuous reaction apparatus as described in claim 1, which is characterized in that groove (203) inner surface is equipped with and described The downside of first transverse slat (200) is equipped with sealed bolster layer.

5. continuous reaction apparatus as described in claim 1, which is characterized in that the reaction kettle (100) is communicated with pneumatic tube (101)。