CN208611342U - A kind of dual chamber liquid liquid infusion bag for packing amino acid and glucose injection - Google Patents

Abstract

Double-chamber transfusion bag is prepared using multi-layer compound structure the utility model relates to a kind of.The multi-layer compound structure improves the security performance and quality stability of dual cavity infusion products, extends product quality guarantee period.

Description

A kind of dual chamber liquid liquid infusion bag for packing amino acid and glucose injection

Technical field

The utility model relates to a kind of dual cavity liquid liquid infusion bag of multi-layer compound structure more particularly to a kind of packaging compounds The double-chamber transfusion bag of amino acid and glucose injection.

Background technique

Parenteral nutrition is the nutritional support mode of whole nutritional factors needed for supplying patient by intravenous route, makes patient A kind for the treatment of method of good nutrition state is maintained in the case where not feeding.Amino acid-glucose electrolyte injection, as Parenteral nutrition medication, be primarily adapted for use in the supply of oral or enteral nutrition cannot, it is insufficient or support taboo person.

A variety of drugs are sub-packed in multiple chambers an of infusion bag by multi-cavity chamber infusion bag, and each component is in production, transport With isolation is remained in storage, separated between each chamber by openable weak welding rod, in use, by apply external force Weak welding rod is opened, multicell communicates, and drug is sufficiently mixed, and is infused to human body by medical liquid discharge port.It is weak in multi-cavity chamber infusion bag Welding rod plays a significant role, and the setting of weak welding rod should guarantee that each chamber communicates smooth convenient when use, and drug is easy mixing, again It can guarantee that each chamber is thoroughly divided in storage and transportational process, do not occur rupturing, leak etc. to open by mistake opening situation.Dual cavity infusion Bag belongs to one of multi-cavity chamber infusion bag, for being used in mixed way for two kinds of drugs.

Infusion bag product is in transport, outside air can also penetrate progressively through bag body and enter in bag and occur with drug in storage process Reaction, influences the quality of medicament.Especially for the medicament of oxygen sensitive, there is very big quality risk.Meanwhile, it is capable to It include PVC, polyethylene, polypropylene etc. in the material of packaging infusion products soft bag, but above-mentioned material itself has certain lack It falls into, if PVC material contains carcinogenicity plasticizer phthalic acid di-isooctyl (DEHP), since DEHP can be leaked in medical fluid In, long-time service will affect hematopoiesis function；PVC material itself has gas permeability and permeability, defeated if sterilising temp control is bad Liquid bag will appear situations such as whiting is opaque；And polythene material high temperature resistance is poor, makes troubles to high-temperature sterilization, polypropylene Brittleness is higher at low temperature for material.Therefore there is an urgent need to guarantee to be infused from the packaging material that infusion products preferably are applied is screened The safety of product.

Utility model content

It is unique that the purpose of the utility model is to provide a kind of structure novels, easy to use, and can be effectively reduced oxygen The dual-chamber bag of the packaging amino acid and glucose injection of infiltration capacity；The specific scheme is that a kind of packaging amino acid and grape The dual chamber liquid liquid infusion bag of sugared injection, including infusion bag ontology, the infusion bag ontology are divided into two chambers by weak welding rod Room；Infusion bag ontology two sides cover Packed barrier film, are provided with oxygen absorbent between infusion bag ontology and the barrier film, The width of the infusion bag ontology and the ratio of height be 0.6 to 1.0 (such as proportional region 0.7-1.0,0.7-0.8,0.7-0.9, 0.8-0.9,0.8-1.0,0.6-0.9,0.6-0.8,0.6-0.7), one end of the weak welding rod is provided with stress and concentrates circular arc； Described two chambers are packaged with Amino Acid Compound Injection, glucose injection respectively, in which:

(1) Amino Acid Compound Injection and glucose injection are respectively 15 kinds of amino acid (15AA) and 10% Portugal Grape sugar injection, liquid amount are respectively 15 kinds of amino acid (15AA) 500ml and 10% glucose injection 500ml；Or dress liquid Amount is respectively 15 kinds of amino acid (15AA) 1000ml and 10% glucose injection 1000ml；

(2) Amino Acid Compound Injection and glucose injection are respectively 16 kinds of amino acid (16AA) and 48% Portugal Grape sugar injection, liquid amount are respectively 16 kinds of amino acid (16AA) 500ml and 48% glucose injection 500ml；Or dress liquid Amount is respectively 16 kinds of amino acid (16AA) 750ml and 48% glucose injection 750ml；Or

(3) Amino Acid Compound Injection and glucose injection are respectively 16 kinds of amino acid (16AA) and 13.33% Glucose injection, liquid amount are respectively 16 kinds of amino acid (16AA) 400ml and 13.33% glucose injection 600ml.

On the other hand, the utility model provide it is a kind of packaging 15 kinds of amino acid (15AA) and 10% glucose injection it is more Room liquid liquid infusion bag, including infusion bag ontology, the infusion bag ontology are divided at least two chambers by weak welding rod；It is described defeated Liquid bag ontology two sides cover Packed barrier film；At least two chamber be independently packaged with amino acid injection and Glucose injection.

Preferably, the liquid amount volume ratio of 15 kinds of amino acid (15AA) and 10% glucose injection is 1:1；It is described The volume of two chambers is arranged in a manner of being suitable for accommodate respective liquid amount.Optionally, the liquid amount of the amino acid injection For 500ml or 1000ml, the liquid amount of the glucose injection is 500ml or 1000ml.

In a preferred embodiment, the multicell liquid liquid of packaging 15 kinds of amino acid (15AA) and 10% glucose injection Infusion bag, including infusion bag ontology, the infusion bag ontology are divided into two chambers by weak welding rod, wrap in the first chamber Amino acid injection equipped with 500ml is packaged with the glucose injection of 500ml, the infusion bag sheet in the second chamber Body two sides cover Packed barrier film.

In a preferred embodiment, the multicell liquid liquid infusion bag of the packaging amino acid and glucose injection, including it is defeated Liquid bag ontology, the infusion bag ontology are divided into two chambers by weak welding rod, are packaged with 1000ml's in the first chamber Amino acid injection is packaged with the glucose injection of 1000ml in the second chamber, and infusion bag ontology two sides are covered Cover Packed barrier film.

On the other hand, the utility model provides pair of a kind of 16 kinds of amino acid (16AA) of packaging and 48% glucose injection Room bag, including infusion bag ontology, the infusion bag ontology are divided into two chambers by weak welding rod；Infusion bag ontology two sides Face covers Packed barrier film；Described two chambers are independently packaged with amino acid injection and glucose injection.

Preferably, the liquid amount volume ratio of 16 kinds of amino acid (16AA) and 48% glucose injection is 1:1；It is described The volume of two chambers is arranged in a manner of being suitable for accommodate respective liquid amount；Optionally, the liquid amount of the amino acid injection For 500ml or 750ml, the liquid amount of the glucose injection is 500ml or 750ml.

In a preferred embodiment, a kind of dual-chamber bag for packing 16 kinds of amino acid (16AA) and 48% glucose injection, Including infusion bag ontology, the infusion bag ontology is divided into two chambers by weak welding rod, is packaged in the first chamber The amino acid injection of 500ml is packaged with the glucose injection of 500ml, the infusion bag ontology two in the second chamber Side covers Packed barrier film.

In a preferred embodiment, a kind of dual-chamber bag for packing 16 kinds of amino acid (16AA) and 48% glucose injection, Including infusion bag ontology, the infusion bag ontology is divided into two chambers by weak welding rod, is packaged in the first chamber The amino acid injection of 750ml is packaged with the glucose injection of 750ml, the infusion bag ontology two in the second chamber Side covers Packed barrier film.

On the other hand, the utility model provides a kind of 16 kinds of amino acid (16AA) of packaging and 13.33% glucose injection Dual-chamber bag, including infusion bag ontology, the infusion bag ontology be divided into two chambers by weak welding rod；The infusion bag ontology Two sides cover Packed barrier film；Described two chambers are independently packaged with amino acid injection and glucose injection Liquid.Optionally, the liquid amount of the amino acid injection is 400ml, and the liquid amount of the glucose injection is 600ml.

In preferred embodiments, suction is provided between infusion bag ontology described in the utility model and the barrier film Oxygen agent.

Further, the oxygen absorbent is bulk, and quantity is 1 piece or muti-piece.

Further, the oxygen absorbent can be plane coating, stripe coating or netted coating.

Further, the oxygen absorbent can be one or more independent oxygen absorbent packagings.

Further, the oxygen uptake ability of the oxygen absorbent is not less than 100ml, is preferably not less than 200ml.

Further, the oxygen transit dose of the barrier film is not more than 1.0cm³/(m²Its 0.1MPa).

Wherein, oxygen transit dose cm³/(m²Its 0.1MPa) refer under 0.1MPa (atmospheric pressure) pressure differential, often put down The volume for the gas that the barrier film of square rice is penetrated daily.

On the other hand, for need to avoid weak welding rod open by mistake open and need guarantee use when be easy open between there are lances This problem of shield concentrates circular arc using in the same side setting stress；It is the arc-shaped that corner is arched upward inwardly that stress, which concentrates circular arc, Weak welding rod concentrates circular arc to make that stress point is concentrated on cambered one end in artificial open, guarantees appropriate increase by stress Still the weld strength that the weak welding rod opened, and increased is easy when using after the weld strength of weak welding rod can with maximum probability Opening by mistake for weak welding rod is avoided to open.

Further, the same end of the weak welding rod have unidirectional circular arc radian, described one end be weak welding rod with it is defeated One end of liquid bag ontology connection, described one end is preferably one end of liquid feeding mouth.

Further, the arc radius is 5mm between 23mm, preferably 8mm-20mm, such as 8mm, 10mm, 12mm, 15mm, 16mm, 18mm, 20mm.

Further, the weld strength of the weak welding rod is 5N/15mm-12N/15mm, preferably 7N/15mm-10N/ 15mm, such as 7N/15mm, 8N/15mm, 8.5N/15mm, 9N/15mm, 9.5N/15mm, 10N/15mm.

Further, in order to improve medication accuracy and bag stability, the liquid after reducing infusion is remained, the utility model The height of infusion bag ontology described in the dual-chamber bag of offer is not less than width.

It is further preferred that the width of the infusion bag ontology and the ratio of height are 0.6-1.0, such as 0.6,0.7, 0.8,0.9,1.0, more preferably 0.7-1.0.

In a preferred embodiment, any one or more settings in the liquid feeding mouth of the two sides of the bottom of infusion bag ontology exist Middle position far from this chamber, and as medical liquid discharge port, preferably as far as possible and in the short transverse of infusion bag ontology Ipsilateral real welding rod it is close.For example including integrally formed mode, i.e. any in the liquid feeding mouth of infusion bag body bottom portion two sides A or multiple middle positions that this chamber is arranged far from a manner of integrally formed；Preferably, the liquid feeding mouth is as medical fluid Outlet, it is as close with the ipsilateral real welding rod in the short transverse of infusion bag ontology as possible.

The integrally formed mode includes that liquid feeding mouth is arranged in the welding of mouth pipe on the body simultaneously in ontology preparation Position makes a mouthful Guan Yuben body by integral forming.

In a preferred embodiment, the infusion bag ontology of the utility model is multi-layer compound structure with film, mainly by changing Property polypropylene be made, the modified polypropylene material can be selected from the known in the art or high safety that is prepared by a conventional method Property composite material, such as three-layer co-extruded material；Optionally, the infusion bag ontology of the utility model is divided into three layers from the inside to the outside, Middle internal layer is made of polypropylene material, and middle layer is made of polypropylene, polyethylene, the mixing of styrene-ethylene-butadiene copolymer, outside Layer is made of polypropylene, the mixing of styrene-ethylene-butadiene copolymer；Optionally, the infusion bag ontology membrane material internal layer is by poly- third Alkene copolymer, hydrogenated styrene block copolymers, ethylene hydroxy acid ester copolymer composition, middle layer is by polypropylene copolymer, hydrogenation of benzene Ethylene block copolymer composition, outer layer is by polypropylene copolymer, hydrogenated styrene block copolymers composition.

In the utility model amino acid or Amino Acid Compound Injection refer to the compound be made of a variety of amino acid or Compound injection, such as 16 kinds of amino acid injections (16AA) or 15 kinds of amino acid injections (15AA).16 in the utility model Kind amino acid (16AA) is identical as 16 kinds of amino acid injection (16AA) meanings；15 kinds of amino acid (15AA) and 15 kinds of amino acid Injection (15AA) meaning is identical.

15 kinds of amino acid injections (15AA) of the utility model packaging are the amino comprising 15 kinds of amino acid and electrolyte Acid injection, such as comprising 15 kinds of amino acid, potassium ion, sodium ion, magnesium ion cation, acetate, chloride ion, phosphate radical Anion and appropriate glacial acetic acid；15 kinds of amino acid is isoleucine, leucine, lysine hydrochloride (or lysine), egg Propylhomoserin (i.e. methionine), phenylalanine, threonine, tryptophan, valine, arginine, histidine, alanine, glycine, dried meat Propylhomoserin, serine, tyrosine.

10% glucose injection of the utility model packaging is 10% mass volumn concentration comprising calcium chloride It include the 10g glucose in terms of Dextrose Monohydrate, calcium chloride or two in glucose injection, such as every 100ml glucose injection Water calcium chloride and suitable dilute hydrochloric acid.

16 kinds of amino acid injections (16AA) of the utility model packaging are the amino comprising 16 kinds of amino acid and electrolyte Acid injection, such as comprising 16 kinds of amino acid, potassium ion, sodium ion, magnesium ion cation, acetate, chloride ion, phosphate radical Anion and suitable citric acid；16 kinds of amino acid is isoleucine, leucine, lysine hydrochloride (or bad ammonia Acid), methionine (i.e. methionine), phenylalanine, threonine, tryptophan, valine, arginine glutamic acid, histidine monohydrochloride (or histidine), alanine, L-aminobutanedioic acid, glutamic acid, glycine, proline, serine.

48% glucose injection of the utility model packaging is 48% mass volumn concentration comprising calcium chloride Include the 48g glucose in terms of DEXTROSE ANHYDROUS in glucose injection, such as every 100ml glucose injection, calcium chloride and Appropriate citric acid.

13.33% glucose injection of the utility model packaging is 13.33% mass volumn concentration comprising chlorine Change the glucose injection of calcium, such as include the 13.33g glucose in terms of DEXTROSE ANHYDROUS in every 100ml glucose injection, Sodium chloride and appropriate calcium chloride.

In the utility model, the volume of each chamber is arranged in a manner of being suitable for accommodate respective liquid amount.Those skilled in the art Each chamber size can hold respective liquid amount after member is clearly understood that above-mentioned set-up mode, such as infusion bag forming, and It will not cause infusion bag excessive bulging or sunken after dress liquid.

The multicell liquid liquid infusion bag of at least two chambers is preferably double-chamber transfusion bag in the utility model.

The utility model dual-chamber bag is by using the weak welding rod with the equidirectional radian in side, so that when using more easily Weak welding rod is opened, and is opened alternately through the control of weak welding rod weld strength to avoid opening by mistake, ease of use is improved, overcomes Weak welding rod in the prior art exist open by mistake open and using when do not allow contradiction easy to open.

By the way that antioxygen barrier film is arranged in infusion bag outer body, the barrier property of infusion bag and oxygen is improved.In antioxygen Oxygen absorbent is placed between barrier film and infusion bag, further increases the antioxidant capacity of infusion bag, extends the pot-life of medicament, really Protect product safety and stability within the shelf-life.

By the way that the width of infusion bag ontology and the ratio of height is arranged, the position of medical liquid discharge port is set, after reducing infusion Liquid residual, improve the stability of bag body especially in infusion process, improve medication accuracy and safety.

The utility model selects high security modified polypropylene material known in the art compound as three layers of membrane material preparation The infusion bag ontology of structure overcomes risk factors and self-defect that the traditional materials such as PVC come, further improves infusion Heat resistance, clarity and the mechanical strength of bag, improve the safety and stability of infusion products；Simultaneously as trilaminate material Between there is different fusing points, gradually rise from inside to outside so that heat seal from the inside to the outside when welding, make its more it is tight securely, Welding effect this product preferably that meets is to the particular/special requirement of weak weldering and fierce different weld strengths.

Detailed description of the invention

Fig. 1 is the dual-chamber bag structural schematic diagram of the utility model embodiment 1-3；

Fig. 2 is the dual-chamber bag structural schematic diagram of the utility model embodiment 4；

Fig. 3 is the structural schematic diagram of the dual-chamber bag of the utility model embodiment 5-7.

In figure: 1, infusion bag ontology；2, weak welding rod；3, barrier film；4, oxygen absorbent；5, stress concentrates circular arc；6, liquid feeding mouth.

Specific embodiment

The utility model is made a more thorough explanation below with embodiment.The utility model can be presented as it is a variety of not Same form, should not be construed as limited to the exemplary embodiments described herein.

The spatially relative terms such as "upper", "lower" " left side " " right side " can be used herein for ease of explanation, for saying Relationship of the elements or features relative to another elements or features shown in bright figure.It should be understood that in addition in figure Except the orientation shown, spatial terminology is intended to include the different direction of device in use or operation.For example, if in figure Device is squeezed, and is stated as being located at other elements or the element of feature "lower" will be located into other elements or feature "upper".Cause This, exemplary term "lower" may include both upper and lower orientation.Device, which can be positioned in other ways, (to be rotated by 90 ° or is located at Other orientation), it can be interpreted accordingly used herein of the opposite explanation in space.

Embodiment 1

As shown in Figure 1, the multicell liquid liquid infusion bag in the present embodiment, including infusion bag ontology 1, infusion bag ontology 1 pass through Weak welding rod 2 is divided into 2 chambers；1 two sides of infusion bag ontology cover Packed barrier film 3.

In order to further decrease the amount that oxygen penetrates into medicament, oxygen absorbent is provided between infusion bag ontology 1 and barrier film 3 4.The form packed with independent oxygen absorbent is arranged in oxygen absorbent, is placed on the region between infusion bag ontology and barrier film.Oxygen uptake Agent 4 can be bulk, and quantity can be 1 piece, be also possible to muti-piece.

By two compartments of multicell liquid liquid infusion bag distinguish filling 500ml 15 kinds of amino acid injections (15AA) and 10% glucose injection of 500ml, by adjusting the dosage of oxygen absorbent and the thickness of barrier film or material；By trying repeatedly It tests, finds in oxygen absorbent oxygen uptake ability Man Zu≤200ml, barrier bag Yang gas Tou Guo Shuai≤1.0 cm³/(m²·24h·0.1MPa) When, guaranteeing that the not exceeded lower product cost of impurity of the injection of two chambers before the deadline is lower.

Wherein, 10% glucose injection of filling 500ml is composed of the following components: the Portugal 50g in terms of DEXTROSE ANHYDROUS Grape sugar, 0.2-0.4g calcium chloride 2H₂O, appropriate dilute hydrochloric acid, remaining is water.

Wherein, 15 kinds of amino acid injections (15AA) of filling 500ml are made of following components and remaining water:

Embodiment 2

As shown in Figure 1, the dual-chamber bag in the present embodiment, including infusion bag ontology 1, infusion bag ontology 1 are divided by weak welding rod 2 It is divided into 2 chambers；1 two sides of infusion bag ontology cover Packed barrier film 3.

In order to further decrease the amount that oxygen penetrates into medicament, oxygen absorbent is provided between infusion bag ontology 1 and barrier film 3 4.The form packed with independent oxygen absorbent is arranged in oxygen absorbent, is placed on the region between infusion bag ontology and barrier film.Oxygen uptake Agent 4 can be bulk, and quantity can be 1 piece, be also possible to muti-piece.

By two compartments of dual-chamber bag distinguish filling 500ml 16 kinds of amino acid injections (16AA) and 500ml 48% Glucose injection, by adjusting the dosage of oxygen absorbent and the thickness of barrier film or material；By repetition test, find in oxygen uptake Agent oxygen uptake ability Man Zu≤200ml, barrier bag Yang gas Tou Guo Shuai≤1.0cm³/ (m²0.1MPa for 24 hours) when, guaranteeing two The not exceeded lower product cost of the impurity of the injection of chamber before the deadline is lower.

Wherein, 48% glucose injection of filling 500ml is composed of the following components: the Portugal 240g in terms of DEXTROSE ANHYDROUS Grape sugar, 0.4-0.7g calcium chloride, remaining is water.Wherein, 16 kinds of amino acid injections (16AA) of filling 500ml are by with the following group Divide and remaining water form:

Embodiment 3

As shown in Figure 1, the dual-chamber bag in the present embodiment, including infusion bag ontology 1, infusion bag ontology 1 are divided by weak welding rod 2 It is divided into 2 chambers；1 two sides of infusion bag ontology cover Packed barrier film 3.

In order to further decrease the amount that oxygen penetrates into medicament, oxygen absorbent is provided between infusion bag ontology 1 and barrier film 3 4.The form packed with independent oxygen absorbent is arranged in oxygen absorbent, is placed on the region between infusion bag ontology and barrier film.Oxygen uptake Agent 4 can be bulk, and quantity can be 1 piece, be also possible to muti-piece.

Two compartments of dual-chamber bag are distinguished to 16 kinds of amino acid injections (16AA) and the 600ml of filling 400ml 13.33% glucose injection, by adjusting the dosage of oxygen absorbent and the thickness of barrier film or material；Pass through repetition test, hair Present oxygen absorbent oxygen uptake ability Man Zu≤200ml, barrier bag Yang gas Tou Guo Shuai≤1.0cm³/ (m²0.1MPa for 24 hours) when, Guarantee that the not exceeded lower product cost of impurity of the injection of two chambers before the deadline is lower.

Wherein, 13.33% glucose injection of filling 600ml is composed of the following components: the 80g in terms of DEXTROSE ANHYDROUS Glucose, 0.10-0.20g sodium chloride, 0.25-0.40g calcium chloride dihydrate, remaining is water.

Wherein, 16 kinds of amino acid injections (16AA) of filling 400ml are made of following components and remaining water:

Embodiment 4

As shown in Fig. 2, the dual-chamber bag of the present embodiment, still includes the infusion bag ontology for being divided into 2 chambers, with embodiment Unlike 1-3, in order to keep oxygen uptake ability in barrier film uniform, oxygen absorbent 4 is fixed in barrier film 3 with coating form, is applied Layer can be plane coating, stripe coating or netted coating.

Embodiment 5

As shown in figure 3, the infusion bag ontology 1 of the present embodiment, infusion bag ontology 1 are mainly made of modified polypropene, pass through Weak welding rod 2 is divided into 2 chambers, and the weld strength of weak welding rod 2 is 10N/15mm, and in the same side, setting stress concentrates circular arc 5, answers The diameter of power circular arc 5 is 12mm, and stress concentrates circular arc 5 to be located at weak welding rod close to the side of liquid feeding mouth 6；Certainly, in other implementations In example, also it can be set in side of the weak welding rod far from liquid feeding mouth 6.

When using the dual-chamber bag of the present embodiment, infusion bag ontology 1 is taken out from the barrier film 3 of sealing, by infusion bag Ontology is squeezed since the side opposite with liquid feeding mouth to liquid feeding mouth direction in any way, such as with by infusion bag rolled fashion It is squeezed to liquid feeding mouth direction, the stress that stress point concentrates on weak welding rod concentrates 5 region of circular arc, can help the manual of weak welding rod It opens.And the dual-chamber bag of the present embodiment is in storage and transport, and is not susceptible to open by mistake and open.

A series of infusion bag ontologies including the infusion bag ontology of the present embodiment are placed on storage transport test dress It is tested in setting, the structure of these infusion bag ontologies is similar to Example 5, unlike, the stress of these infusion bag ontologies The diameter of circular arc 5 is is respectively 0mm (unstressed circular arc), 2mm, 3mm, 5mm, 8mm, 12mm, 20mm, 25mm, through repetition test It was found that the infusion bag ontology that stress arc diameter is 25mm is significantly larger than this examination in the rate of opening that opens by mistake stored in trafficking experiments device The infusion bag ontology of other stress arc diameters opens by mistake the rate of opening in testing.Further, after storing trafficking experiments, by institute Some infusion bag ontologies take out, manually opened, find through repetition test, and stress arc diameter is the infusion bag of 0mm, 2mm, 3mm Ontology, manually opened difficulty is big, is far longer than the manually opened difficulty of the infusion bag ontology of other stress arc diameters in this test Degree, especially the infusion bag ontology of stress arc diameter 0mm, manually opened difficulty are maximum.

Embodiment 6

As shown in figure 3, the infusion bag ontology 1 of the present embodiment, the width of infusion bag ontology 1 and the ratio of height are 0.8, often A chamber is provided with a liquid feeding mouth 6, and liquid feeding mouth 6 can also be used as medical fluid delivery outlet, in the present embodiment, in order to further The liquid residue for reducing infusion port selects a liquid feeding mouth in two side cavities as medical fluid delivery outlet, exports as medical fluid The position of the liquid feeding mouth of mouth is positioned close to the real welding rod side in the short transverse of this chamber in a manner of being integrally formed, in this reality It applies in example, the liquid feeding mouth of two side cavities is arranged in this wise, and the option as medical fluid delivery outlet is selective.In fact, should Understand, the liquid feeding mouth of leftmost side chamber or rightmost side chamber also can be set in a manner of being for example integrally formed as close to most Real welding rod in the short transverse of left side or the rightmost side, the liquid feeding mouth being arranged so are preferentially selected as medical fluid output when in use Mouthful, there is no restriction for the setting position of the liquid feeding mouth of other chambers.

Dual-chamber bag is distinguished to 48% glucose injection of 16 kinds of amino acid injections (16AA) and 750ml of filling 750ml The ratio of liquid, the width and height that adjust different infusion bag ontologies obtains different pouch-shapeds；By repetition test, find in width When ratio with height is 1.2, the Liquid Residue scale of construction will be more than 1%, extreme influence infusion accuracy.

Different in width and the infusion bag ontology of height ratio (the ratio of width to height) are further subjected to filling test (the 16 of 750ml 48% glucose injection of kind amino acid injection (16AA) and 750ml), in addition to width is different with height ratio, infusion The other structures feature of bag is identical as the present embodiment, width and height ratio be respectively 0.5,0.7,0.8,0.9,1.0,1.3, 1.5, it is found by repetition test, width and height ratio are bright for the liquid residue of 0.5 and 1.3,1.5 infusion bag ontology The aobvious infusion bag ontology for being 0.7,0.8,0.9,1.0 greater than width and height ratio, and at the end of infusion closes on, width The infusion bag ontology for being 0.5 and 1.3,1.5 with height ratio is easier to incline than the infusion bag of other the ratio of width to height in this test Tiltedly.

10% glucose injection of 15 kind amino acid (15AA) injections and 1000ml of the test bag equipped with 1000ml Dual-chamber bag is packaged with 13.33% glucose injection of 16 kinds of amino acid injections (16AA) and 600ml of 400ml, and packaging There is the dual-chamber bag of 15 kinds of amino acid injections (15AA) of 500ml and 10% glucose injection of 500ml, test result is same On.The parameter for being also simultaneously 0.6 to height and width ratio is tested, as the result is shown the ratio infusion bag tilt stability It is suitable with the range of 0.7-1.0 with raffinate amount.

Embodiment 7

15 kinds of amino acid injections (15AA) and the 500ml of filling 500ml are distinguished in dual-chamber bag shown in Fig. 3 10% glucose injection investigates the packaging material performance of the infusion bag after 121 DEG C of moist heat sterilizations using the product as example,

Specific method includes:

Thermal adaptability: taking 10 bags of each batch of sample inner bag, under the conditions of -25 DEG C ± 2 DEG C, places 24 hours, then 50 Under the conditions of DEG C ± 2 DEG C, continue to place 24 hours, then under the conditions of 23 DEG C ± 2 DEG C, places 24 hours, it is flat that sample is first placed in two Between row plate, the internal pressure of 30kPa is born, is maintained 10 minutes, investigates whether weak weldering position opens；By appropriate ways by weak weldering After item fully opens, sample is placed between two parallel plates, bears the internal pressure of 67kPa, is maintained 10 minutes, checks bag body surrounding (real weldering position) has no liquid leakage.

Light transmittance: taking 5 bags of each batch of sample, discard chamber contents, chooses the smooth position of ontology, is cut into 5 0.9cm The slice of × 4cm, is cleaned up with deionized water, is put into absorption cell along incident light vertical direction respectively, topped up with water, and with water As blank, according to UV-VIS spectrophotometry (four general rules 0401 of " Chinese Pharmacopoeia " version in 2015), surveyed at 450nm Determine light transmittance.

Inner bag heat sealing strength: taking 1 bag of each batch of sample, according to compound in heat sealing strength measuring method (YBB00122003-2015) The method measurement of bag.

Overall tightness: taking 10 bags of each batch of sample, is respectively put into sample in the closed container of dress water, keeps bag body in water It is middle to be flooded completely, to the negative pressure of container application -67kPa, 5min is kept, has seen whether that bubble is overflowed from bag body into water.

Test result is as follows:

By test result it is found that three layers of infusion bag being made into of modified polypropylene material are selected in the utility model, at 121 DEG C Still have good light transmittance in each test phase after moist heat sterilization, 87% or more, meet relevant criterion, shows this Utility model membrane material heat resistance is good；The membrane material weak weldering position in temperature adaptability test is able to bear the pressure of 30kPa Power and be not turned on, real weldering is able to bear the pressure of 67kDa and no liquid leaks out, and weldering part heat sealing strength is not in fact for inner bag bag body surrounding Lower than 20N/15mm, weak weldering position is not less than 5N/15mm, and is not higher than 12N/15mm, and infusion bag overall tightness is good, can See the heat seal welding carried out using the utility model trilamellar membrane material, can be good at adapting to the weak weldering of this double-chamber transfusion bag and welds in fact It is specific to need, product mechanical strength with higher.

After two-chamber injection is mixed, the compatibility and safety of infusion bag material and injection are further investigated, as a result It is as shown in the table:

The results show that the infusion bag of the utility model modified polypropene material preparation, not plasticizer-containing, with amino acid Good with glucose injection compatibility, conventional character is good, osmotic pressure molar density, visible foreign matters, particulate matter, bacterium Detection, endotoxin detection, undue toxicity detection and conventional shape etc. meet pharmacopoeial requirements, show the compound ammonia of the utility model Base acid and glucose injection liquid two-chamber transfusion Product Safety are good.

In conclusion the dual-chamber bag of the application has the following characteristics that

(1) the setting extension of oxygen absorbent and barrier bag includes the pharmaceutical liquid pot-life；

(2) welding rod is not easy to open by mistake during transporting or save, and it is convenient to open when use；

(3) discharge of the Width x Height than being conducive to include pharmaceutical liquid of the setting position of outlet, pouch-shaped；

(4) selection of modified polypropene membrane material further improves drug safety, clarity and mechanical performance.

Above-mentioned example is only intended to illustrate the utility model, and in addition to this, also there are many different embodiments, and these Embodiment be all those skilled in the art after comprehension the utility model thought it is also envisioned that therefore, no longer arrange one by one herein It lifts.

Claims (9)

1. a kind of dual chamber liquid liquid infusion bag for packing amino acid and glucose injection, including infusion bag ontology, described defeated Liquid bag ontology is divided into two chambers by weak welding rod；Infusion bag ontology two sides cover Packed barrier film, infusion bag sheet Oxygen absorbent is provided between body and the barrier film, the width of the infusion bag ontology and the ratio of height are 0.7 to 0.9, described One end of weak welding rod is provided with stress and concentrates circular arc, and it is 5mm between 23mm that the stress, which concentrates the arc radius of circular arc,；It is described Two chambers are packaged with Amino Acid Compound Injection, glucose injection respectively, in which:

(1) Amino Acid Compound Injection and glucose injection are respectively 15 kinds of amino acid (15AA) and 10% glucose note Liquid is penetrated, liquid amount is respectively 500ml and 500ml；Or liquid amount is respectively 1000ml and 1000ml；

(2) Amino Acid Compound Injection and glucose injection are respectively 16 kinds of amino acid (16AA) and 48% glucose note Liquid is penetrated, liquid amount is respectively 500ml and 500ml；Or liquid amount is respectively 750ml and 750ml；Or

(3) Amino Acid Compound Injection and glucose injection are respectively 16 kinds of amino acid (16AA) and 13.33% grape Sugared injection, liquid amount are respectively 400ml and 600ml.

2. dual chamber liquid liquid infusion bag according to claim 1, wherein the width of the infusion bag ontology and the ratio of height replace It is changed to 0.7 to 1.0 range, and any one or more in the liquid feeding mouth of the two sides of the bottom of infusion bag ontology are with integrally formed Mode is arranged far from the middle position of this chamber.

3. dual chamber liquid liquid infusion bag according to claim 2, wherein the liquid feeding mouth is as medical liquid discharge port, as far as possible with Ipsilateral real welding rod in the short transverse of infusion bag ontology is close.

4. dual chamber liquid liquid infusion bag according to claim 1 or 2, which is characterized in that the oxygen absorbent is bulk, and quantity is 1 piece or muti-piece；Or the oxygen absorbent is plane coating, stripe coating or netted coating；Or the oxygen absorbent is one or more Independent oxygen absorbent packaging.

5. dual chamber liquid liquid infusion bag according to claim 1 or 2, which is characterized in that the oxygen uptake ability of the oxygen absorbent is not Less than 200ml；Or the oxygen transit dose of the barrier film is not more than 1.0cm³/(m²Its 0.1MPa).

6. dual chamber liquid liquid infusion bag according to claim 1 or 2, which is characterized in that the stress concentrates circular arc setting to exist Close to one end of liquid feeding mouth.

7. dual chamber liquid liquid infusion bag according to claim 1 or 2, which is characterized in that the stress concentrates the circular arc of circular arc Radius is 8mm-20mm.

8. dual chamber liquid liquid infusion bag according to claim 1 or 2, which is characterized in that the weld strength of the weak welding rod is 5N/15mm-12N/15mm。

9. dual chamber liquid liquid infusion bag according to claim 1 or 2, wherein by the width of the infusion bag ontology and height Than the range for replacing with 0.6 to 1.0.