CN208610817U - A kind of animal intestines and stomach Dynamic testing system - Google Patents
A kind of animal intestines and stomach Dynamic testing system Download PDFInfo
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- CN208610817U CN208610817U CN201721790039.3U CN201721790039U CN208610817U CN 208610817 U CN208610817 U CN 208610817U CN 201721790039 U CN201721790039 U CN 201721790039U CN 208610817 U CN208610817 U CN 208610817U
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- Prior art keywords
- marker
- grasping part
- testing system
- dynamic testing
- animal intestines
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- 241001465754 Metazoa Species 0.000 title claims abstract description 38
- 210000000936 intestine Anatomy 0.000 title claims abstract description 31
- 210000002784 stomach Anatomy 0.000 title claims abstract description 29
- 238000012360 testing method Methods 0.000 title claims abstract description 20
- 239000003550 marker Substances 0.000 claims abstract description 80
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims abstract description 20
- 229910052742 iron Inorganic materials 0.000 claims abstract description 10
- 229910052788 barium Inorganic materials 0.000 claims abstract description 4
- DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 claims abstract description 4
- 239000000203 mixture Substances 0.000 claims abstract description 4
- 239000000463 material Substances 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- 239000000741 silica gel Substances 0.000 claims description 3
- 229910002027 silica gel Inorganic materials 0.000 claims description 3
- 238000001514 detection method Methods 0.000 abstract description 9
- 230000001427 coherent effect Effects 0.000 abstract description 2
- 238000000034 method Methods 0.000 description 13
- 238000010171 animal model Methods 0.000 description 11
- 210000002318 cardia Anatomy 0.000 description 6
- 230000006870 function Effects 0.000 description 5
- 230000002496 gastric effect Effects 0.000 description 5
- 238000007689 inspection Methods 0.000 description 5
- 230000007659 motor function Effects 0.000 description 5
- 210000003238 esophagus Anatomy 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 230000030136 gastric emptying Effects 0.000 description 4
- 210000001035 gastrointestinal tract Anatomy 0.000 description 4
- 239000000976 ink Substances 0.000 description 4
- 210000001187 pylorus Anatomy 0.000 description 4
- 238000011161 development Methods 0.000 description 3
- 210000003608 fece Anatomy 0.000 description 3
- NTHXOOBQLCIOLC-UHFFFAOYSA-N iohexol Chemical compound OCC(O)CN(C(=O)C)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I NTHXOOBQLCIOLC-UHFFFAOYSA-N 0.000 description 3
- 229960001025 iohexol Drugs 0.000 description 3
- 230000033001 locomotion Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 206010002091 Anaesthesia Diseases 0.000 description 2
- 208000017228 Gastrointestinal motility disease Diseases 0.000 description 2
- 230000037005 anaesthesia Effects 0.000 description 2
- 238000007599 discharging Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 208000021302 gastroesophageal reflux disease Diseases 0.000 description 2
- 230000005176 gastrointestinal motility Effects 0.000 description 2
- 208000002551 irritable bowel syndrome Diseases 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000004400 mucous membrane Anatomy 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 210000000436 anus Anatomy 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000002872 contrast media Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000004043 dyeing Methods 0.000 description 1
- 201000006549 dyspepsia Diseases 0.000 description 1
- 238000002594 fluoroscopy Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000007794 visualization technique Methods 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus For Radiation Diagnosis (AREA)
Abstract
The utility model discloses a kind of animal intestines and stomach Dynamic testing system, the detection system includes marker, marker gripping device；The marker is layer structure, is followed successively by marker kernel, marker inner casing and marker shell from inside to outside, and the marker kernel is the mixture of radiopaque iron or barium；The marker gripping device includes grasping part, controller and the elongated interconnecting piece that the two is connected；The end of the grasping part forms the opening for accommodating marker；The controller controls grasping part to the grasping of marker or loosens.The utility model can continuous, dynamic observation animal intestines and stomach power coherent detection index, have broad application prospects.
Description
Technical field
The utility model relates to gastroenteritic power detection system field, specifically a kind of animal intestines and stomach Dynamic testing system.
Background technique
Gastrointestinal motility disorders are very common, and all-digestive tract almost can be involved, and relate generally to gastroesophageal reflux disease
(GERD), functional dyspepsia FD (FD), irritable bowel syndrome (IBS) and functional consitipation (FC) etc..In recent years, with society
Economic fast development, the illness rate of gastrointestinal motility disorders are in rise year by year trend, and the disease seriously affects patient
Quality of life, thus receive more and more attention.
The method multiplicity of current experimental animal gastroenteritic power function detection, mainly include the following types: 1. radionuclides
Visualization method: this method is in body, noninvasive gastroenteritic power detection method.The oral drug containing radioisotope labeling
After the standard test-meal of (99mTc-SC or 111In-DTPA), chronophotograph is carried out in inspection area through γ-camera, according in stomach
The amount of food radionuclide carrys out evaluating gastrointestinal motility.The shortcomings that this method, essentially consists in the high requirements on the equipment, there is nuclear radiation risk,
And expense is high, takes a long time, animal compliance is poor, these seriously limit the application of this method.2. India ink staining: the party
Method puts to death animal, dissociate gastrointestinal tract, measurement stomach to prepared Chinese ink by giving animal stomach-filling with a certain concentration india ink after a certain period of time
The distance of distal end is dyed, indicates Gastrointestinal Motility In Animals function accordingly.The shortcomings that this method, which is that animal must be put to death, to carry out
Measurement, can only detect the gastrointestinal movement functional parameter an of time point, cannot achieve dynamic monitoring, move if you need to multiple time points
Functional parameter then needs a point multiple groups, puts to death animal respectively at different time points, can detect, cause largely to waste, and because of ink dyeing
Mucous membrane is polluted, the pathological research of mucous membrane sample is unfavorable for.3, alimentary canal pressure testing method, this method is led by the way that zoopery is dedicated
Pressure in pipe measurement experiment animal oesophagus or colorectum reflects gastrointestinal motor function indirectly.But this method is logical by conduit
Road quantity and catheter length limitation, can not accurately, intuitively reflect all-digestive tract motor function, and can only measure the short time, nothing
Method provides the alimentary canal dynamic motion performance data of long time-course experiments animal, in addition, this method needs pressure instrumentataion to provide support,
Which has limited its extensive uses.Animal alimentary canal motor function inspection method described above cannot be examined in addition to drawbacks described above
Survey experimental animal oesophagus air emptying function.
With the development of society, domestic pets are more and more common.Pet disease much shows as diarrhea, constipation, vomiting etc.
Gastrointestinal symptom, targetedly detection methods are few at present, and all can not directly reflect gastrointestinal movement function；And specific aim stomach
Instestinal motility inspection lacks, and causes medication specific aim poor, this seriously constrains the development of Medical pet, increases family burden.
Utility model content
The utility model is just to provide for a kind of animal intestines and stomach Dynamic testing system, with dynamic, safe and accurate realization
Acquisition to all-digestive tract (oesophagus, stomach, intestines) power function index, and repeated multiple times can measure, to reduce disappearing for experimental animal
Consumption.
The utility model is realized according to following technical scheme.
A kind of animal intestines and stomach Dynamic testing system, including marker, marker gripping device；The marker is stratiform knot
Structure, is followed successively by marker kernel, marker inner casing and marker shell from inside to outside, and the marker kernel is radiopaque
The mixture of iron or barium；The marker gripping device includes grasping part, controller and the elongated connection that the two is connected
Portion；The end of the grasping part forms the opening for accommodating marker；Controller control grasping part to the grasping of marker or
It loosens.
It further, is cavity structure inside the grasping part and interconnecting piece；During the terminus inner of the grasping part is equipped with
Centre has the suction unit of through-hole, and the suction unit is magnet, attracts each other with the marker inner casing being made of iron or magnet；It pushes away
Lever one end penetrates in the through-hole in suction unit center, and the other end passes through interconnecting piece and connect with controller；It is equipped in the controller
Stepper motor, the rotor of stepper motor are connected with one end of catch bar.
It further, is cavity structure inside the grasping part and interconnecting piece；During the terminus inner of the grasping part is equipped with
Centre has the suction unit of through-hole, and the suction unit is magnet, attracts each other with the marker inner casing being made of iron or magnet；Institute
Controller is stated to pass through air pressure or hydraulic control grasping part to the grasping of marker or loosen.
Further, the marker shell is silica gel material.
Further, the marker is spherical, elliposoidal or stub shape.
Further, the outer wall of the interconnecting piece is equipped with graduated scale.
Further, the magnet is permanent magnet or electromagnet.
The utility model obtains following beneficial effect.
The utility model can be under the conditions of non-execution, continuous observation animal intestines and stomach evacuating pipeline situation；Extend observing time, it can
Obtain the animal entirely data such as gastral emptying time, Emptying Rate；The utility model can it is continuous, dynamic observation animal intestines and stomach is dynamic
Power coherent detection index, reduces the expense in terms of equipment, consumptive material and animals consuming, and greatly improves the intuitive of experimental result
Property, continuity and accuracy, are of great significance in terms of animal intestines and stomach Dynamic testing.
Detailed description of the invention
Fig. 1 is the sectional view of the utility model marker；
Fig. 2 is the structural schematic diagram of the utility model marker gripping device；
Fig. 3 is the sectional view of marker gripping device in the utility model embodiment 1；
Fig. 4 is the sectional view of marker gripping device in the utility model embodiment 2.
Wherein: 1. markers；1a. marker kernel；
1b. marker inner casing；1c. marker shell；
2. grasping part；3. interconnecting piece；
4. controller；5. suction unit；
6. catch bar；7. through-hole.
Specific embodiment
The utility model is described further with reference to the accompanying drawings and embodiments.
As shown in Figure 1, 2, a kind of animal intestines and stomach Dynamic testing system, including marker 1, marker gripping device；It is described
Marker 1 is layer structure, is followed successively by marker kernel 1a from inside to outside, marker inner casing 1b and marker shell 1c, described
Marker kernel 1a is the mixture of radiopaque iron or barium；The marker gripping device include grasping part 2, controller 4 with
And the elongated interconnecting piece 3 that the two is connected；The end of the grasping part 2 forms the opening for accommodating marker 1；The controller
4 control grasping parts 2 to the grasping of marker 1 or loosen.
The utility model can use different inner diameters and density according to the oesophagus internal diameter and conventional food density of target animal
Marker 1.
The marker shell 1c is silica gel material.
The marker 1 is spherical, elliposoidal or stub shape.
The outer wall of 3 length of the interconnecting piece about 5cm, interconnecting piece 3 are equipped with graduated scale, insert according to graduated scale is controllable
Enter depth, is allowed to be positioned exactly at introitus oesophagi.
The magnet is permanent magnet or electromagnet.
Embodiment 1
As shown in figure 3, being cavity structure inside the grasping part 2 and interconnecting piece 3；The terminus inner of the grasping part 2 is set
There is center to have the suction unit 5 of through-hole 7, the suction unit 5 is magnet, with the marker inner casing 1b phase being made of iron or magnet
Mutually attract；6 one end of catch bar penetrates in the through-hole 7 in 5 center of suction unit, and the other end passes through interconnecting piece 3 and connect with controller 4；Institute
It states and is equipped with stepper motor in controller 4, the rotor of stepper motor is connected with one end of catch bar 6.
Forward driving stepper motor, catch bar 6 move forward, and catch bar 6 pushes marker 1 to separate with suction unit 5, in turn
Marker 1 is released to experimental animal esophagus；It is driven in the reverse direction stepper motor, catch bar 6 moves backward, and makes another mark
Object 1 attracts each other with suction unit 5, into the circulation for discharging next marker 1.
Embodiment 2
As shown in figure 4, being cavity structure inside the grasping part 2 and interconnecting piece 3；The terminus inner of the grasping part 2 is set
There is center to have the suction unit 5 of through-hole 7, the suction unit 5 is magnet, with the marker inner casing 1b phase being made of iron or magnet
Mutually attract；The controller 4 passes through air pressure or hydraulic control grasping part 2 to the grasping of marker 1 or loosens.
The air pressure is formed by air pump；It is described it is hydraulic formed by syringe or hydraulic cylinder, the liquid of injection can be to make
Shadow agent, such as Iohexol.
Thrust is generated by injecting a certain amount of gas or liquid into interconnecting piece 3 and grasping part 2, marker 1 is pushed to be detached from
Suction unit 5, hence into experimental animal esophagus；After the completion of first marker 1 discharges, by another marker 1 and inhale
Draw portion 5 to attract each other, into the circulation for discharging next marker 1.
Experimental animal gastroenteritic power detection method: after Animal Anesthesia, first with a certain amount of, certain density Iohexol (with
For mouse, every mouse gives the Iohexol that 0.1ml concentration is 320mg/ml) sketch the contours of alimentary canal profile.Then orally exist
Experimental animal esophagus release mark object 1 makes it with experimental animal gastrointestinal motor and is discharged to anus side, in 1 row of marker
Except in the process, following parameter can be obtained:
Esophageal Motor Function parameter: by introitus oesophagi, (1 position of release mark object is defined as X1), cardia is defined as X2, food
Pipe maximum gauge is X3~X4.Record X1To X2Between distance L(using opacity scale as physical length object of reference), and detect mark
The run duration T that will object 1 passes through two positions point.Can get Esophageal Motor Function index after the completion of detection: experimental animal oesophagus is most
Major diameter is X3-X4Distance；Oesophagus intestine evacuation velocity: V=L/T (cm/s)；Oesophagus section intestine evacuation velocity: oesophagus section starting point definition
For Xm, this section of length of esophagus are as follows: Lm=X2-Xm, marker 1 passes through XmTo passing through X2Time is denoted as Tm, then this section of oesophagus emptying is fast
Degree is Lm/Tm。
Gastric emptying parameter: after dynamic observation marker 1 enters cardia under x-ray, extend observing time, and measure marker 1
The pylorus time is left, this is the gastric emptying time, and wherein marker 1 is denoted as L from cardia to discharge pylorus length is enteredn, whole section of row
The time is denoted as T outn, gastric emptying speed is Ln/Tn。
Stomach and intestine evacuating pipeline parameter: after several pieces of markers 1 enter cardia, anesthesia is released, is normally bred experimental animals, periodically
The excrement of experimental animal discharge is collected, x-ray inspection is carried out, counts 1 quantity of marker in excrement, then gastrointestinal tract in this time interval
Emptying Rate: (nRow/nAlways) %.(such as only row stomach and intestine evacuating pipeline inspection, then unnecessary contrast agent in advance sketches the contours alimentary canal profile)
This patent is using the double-deck rearging cage feeding experiment animal, and the bilayer rearging cage is upper layer and lower layer structure, and upper layer is
Animal feeding area, lower layer are excreta collection area；The bottom surface on the upper layer is in rail shape, between each rack stake between be divided into guarantor
Barrier animal does not fall into the largest interval of bottom, with sharp collecting dung；The lower layer bottom surface is equipped with the pumping big with upper layer undersurface etc.
Lattice collect excrement convenient for complete.
Experiment statistics result
1. mouse oesophagus empties parameter
Marker through 15 measuring animal intestines and stomach Dynamic testing systems repeatedly intestine evacuation velocity in mouse oesophagus, puts down
Equal length is 2.6200 ± 0.1897cm, and average emptying time is 24.4667 ± 4.7640s, and average intestine evacuation velocity is 0.1108
±0.0227cm/s。
2. mouse oesophagus section empties parameter
Through 10 measurings repeatedly, the marker of animal intestines and stomach Dynamic testing system different length portion in mouse oesophagus
The intestine evacuation velocity of position, average length are 1.7220 ± 0.4868cm, and average emptying time is 15.5600 ± 5.7030s, average to arrange
Air speed degree is 0.1146 ± 0.0234cm/s.
3. mouse gastric emptying parameter (marker is from cardia is entered to the discharge pylorus time)
Through 10 measurings repeatedly, the marker of animal intestines and stomach Dynamic testing system (cardia to pylorus) in Mouse Stomach
Intestine evacuation velocity, average length is 1.3330 ± 0.2062cm, and average emptying time is 27.1100 ± 3.7230s, average to empty
Speed is 0.0496 ± 0.0075cm/s.
4. mouse GI tract empties parameter, (investment collects excreta and carries out x-ray fluoroscopy, statistics row after marker 24 hours
Empty rate)
Through 10 measurings repeatedly, the marker of animal intestines and stomach Dynamic testing system averagely empties in mouse GI tract
Rate is 89.33%.
Claims (7)
1. a kind of animal intestines and stomach Dynamic testing system, it is characterised in that: including marker (1), marker gripping device；The mark
Will object (1) is layer structure, is followed successively by from inside to outside marker kernel (1a), marker inner casing (1b) and marker shell
(1c), the marker kernel (1a) are the mixture of radiopaque iron or barium；The marker gripping device includes grasping part
(2), controller (4) and the elongated interconnecting piece (3) that the two is connected；The end of the grasping part (2), which is formed, accommodates mark
The opening of object (1)；The controller (4) controls grasping part (2) to the grasping of marker (1) or loosens.
2. a kind of animal intestines and stomach Dynamic testing system according to claim 1, it is characterised in that: the grasping part (2) and
It is cavity structure inside interconnecting piece (3)；The terminus inner of the grasping part (2) is equipped with the suction unit that center has through-hole (7)
(5), the suction unit (5) is magnet, is attracted each other with the marker inner casing (1b) being made of iron or magnet；Catch bar (6)
One end penetrates in the through-hole (7) in suction unit (5) center, and the other end passes through interconnecting piece (3) and connect with controller (4)；The control
Stepper motor is equipped in device (4), the rotor of stepper motor is connected with one end of catch bar (6).
3. a kind of animal intestines and stomach Dynamic testing system according to claim 1, it is characterised in that: the grasping part (2) and
It is cavity structure inside interconnecting piece (3)；The terminus inner of the grasping part (2) is equipped with the suction unit that center has through-hole (7)
(5), the suction unit (5) is magnet, is attracted each other with the marker inner casing (1b) being made of iron or magnet；The controller
(4) pass through air pressure or hydraulic control grasping part (2) to the grasping of marker (1) or loosen.
4. a kind of animal intestines and stomach Dynamic testing system according to claim 1,2 or 3, it is characterised in that: the marker
Shell (1c) is silica gel material.
5. a kind of animal intestines and stomach Dynamic testing system according to claim 1,2 or 3, it is characterised in that: the marker
It (1) is spherical, elliposoidal or stub shape.
6. a kind of animal intestines and stomach Dynamic testing system according to claim 1,2 or 3, it is characterised in that: the interconnecting piece
(3) outer wall is equipped with graduated scale.
7. a kind of animal intestines and stomach Dynamic testing system according to claim 2 or 3, it is characterised in that: the magnet is forever
Magnet or electromagnet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721790039.3U CN208610817U (en) | 2017-12-20 | 2017-12-20 | A kind of animal intestines and stomach Dynamic testing system |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721790039.3U CN208610817U (en) | 2017-12-20 | 2017-12-20 | A kind of animal intestines and stomach Dynamic testing system |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208610817U true CN208610817U (en) | 2019-03-19 |
Family
ID=65690959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721790039.3U Withdrawn - After Issue CN208610817U (en) | 2017-12-20 | 2017-12-20 | A kind of animal intestines and stomach Dynamic testing system |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN208610817U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108030471A (en) * | 2017-12-20 | 2018-05-15 | 天津医科大学总医院 | Animal intestines and stomach Dynamic testing system and detection method |
-
2017
- 2017-12-20 CN CN201721790039.3U patent/CN208610817U/en not_active Withdrawn - After Issue
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108030471A (en) * | 2017-12-20 | 2018-05-15 | 天津医科大学总医院 | Animal intestines and stomach Dynamic testing system and detection method |
| CN108030471B (en) * | 2017-12-20 | 2023-12-26 | 天津医科大学总医院 | Animal gastrointestinal motility detection system and detection method |
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