CN2085662U

CN2085662U - Productive device for "osmotic pump" of medicines

Info

Publication number: CN2085662U
Application number: CN 91211396
Authority: CN
Inventors: 毕勇; 王兵; 徐俊杰
Original assignee: Individual
Current assignee: Individual
Priority date: 1991-03-29
Filing date: 1991-03-29
Publication date: 1991-10-02

Abstract

The utility model discloses a device for producing a medicine osmotic pump, particularly a device which is used for perforating small medicine releasing holes on a medicine coating body. In the utility model, various machines with a delivery track, a delivery hole plate or a mould are respectively provided with a laser machine, or other perforating devices, which causes the medicine coating body be perforated with small medicine releasing holes to meet the requirement of the preparation of various medicine osmotic pumps. The utility model can be suitable for the big production process of various medicine osmotic pumps for industries such as medicine, fertilizer, chemical industry, etc.

Description

Productive device for "osmotic pump" of medicines

This utility model relates to the process units of a kind of medicine " osmotic pumps ", particularly a kind of utilization has the machine of delivery track or conveying, counting orifice or all kinds of moulds perforating device is installed, make it can get the device of small delivery aperture on request on semipermeable membrane coating body, it is applicable to the big production of pharmaceuticals industry, chemical fertilizer, chemical industry various kinds of drug " osmotic pumps ".

The medicine " osmotic pumps " of pharmaceuticals industry development at present is after medicine is used the semipermeable membrane coating, on the one side of coating body or two, beat one or several aperture again, medicine is disengaged in the speed aperture on request promptly make so-called " osmotic pumps ", to reach medicine is carried out slow release, the purpose of controlled release, the production of domestic medicine " osmotic pumps " also is in the starting stage at present, production method all is after medicine is used the semipermeable membrane coating, on each coating body, stamp small delivery aperture with laser or mechanical means on request by operator are manual, though the packaging technique of tablet has belonged to mature technology, traditional pan coating method is through improving the specification requirement and the big needs of producing that also can satisfy medicine " osmotic pumps " semipermeable membrane coating, and many research units have worked out the multiple kind that is suitable for medicine " osmotic pumps ", but because " osmotic pumps " goes up hole diameter, the degree of depth is all influential to the release parameter, rely on and manually particularly on less coating body (or sheet), spiling on the coating body (or sheet), not only exist the production difficulty big, efficient is low, easily no marking, the problem of easy microbiological contamination, the quality of product also is difficult for guaranteeing, therefore, the popularization of present domestic medicine " osmotic pumps " and big production have been subjected to considerable restraint, " osmotic pumps " of external development and production has polytype, the punching process all is by the special special equipment that makes of the requirement of all kinds of " osmotic pumps ", this kind equipment all contains the location of coating body, carry, the mould of perforating device and plurality of specifications, complex structure, cost an arm and a leg and do not see as yet that up to the present the modular system that this respect is arranged sells, it also is the key factor that medicine " osmotic pumps " not can manufacture at home.

Task of the present utility model just provides a kind of process units that is applicable to the big method ┈ medicine " osmotic pumps " of producing of medicine " osmotic pumps ", it promptly is a kind of device of on semipermeable membrane coating body, getting small delivery aperture, it is at the packing counting machine, on the sugar-coat ink writer, particularly on bubble-cap formula Aluminium-coating Packer, settle perforating device and utilize drug coating body localized naturally fundamental characteristics in the course of conveying on machine, after making the coating body that wraps semipermeable membrane in packaging process, be stamped required small delivery aperture by grain, promptly pack, the required all kinds of location of coated tablet punching have been saved, conveying mechanism and Mould design and manufacturing, it can satisfy the big requirement of producing of preparation medicine " osmotic pumps " simultaneously.

Of the present utility model taking care of in the following manner finished: add the tablet (or coating body) that has been surrounded by semipermeable membrane in the hopper of bubble-cap formula Aluminium-coating Packer, warp sheet track down enters established PVC or the interior location naturally of PP thin film bubble-cap on the bubble-cap formula Aluminium-coating Packer, when being fed forward, lack the sheet detection through photo-electric machinery contact pin type or the scarce sheet checkout gear of other form again, be the reliability of guaranteeing to detect, also available two scarce sheet detect " with " door system control is installed in perforating device thereafter, but perforating device system is with other open type perforating device of laser generator punching mechanical punching, and it is through adjusting the equal may command punching degree of depth and diameter; Seal again, cut after the tablet that the scarce sheet of process detects is punched by perforating device and both be finished product; I do not punch if row (the maybe part of this row) perforating device that the scarce sheet checkout gear of warp records scarce sheet can both be failure to actuate automatically, treat heat sealed package, behind the stamping-out, machine is discharged it certainly, right it is dropped into again repeated the above cycle in the hopper, above-mentioned laser, machinery or other perforating device also can place following orbital position or several pieces packers of common orifice plate of bubble-cap formula packer, several pieces orifice plates of several pieces packers of crawler type and other number of types sheet packer or crawler belt place, and can make a call to one on request simultaneously, two or more small delivery aperture, the made aperture of said apparatus is generally between 5 μ m--2mm, each punching grain number is the 1--20 grain, per minute punching frequency is less than 300 times, the punching degree of depth can be adjusted on request, also can accomplish only to penetrate film and do not touch its inner medicine that wraps, simultaneously, this mode also may extend to track, the mould location, on all kinds of machines of carrying, on the coated tablet ink writer, beat small delivery aperture in the track course of conveying before or after the coated tablet lettering, both settled perforating device, utilize mould and conveyer device on the former machine, also can reach the purpose of preparation medicine " osmotic pumps ".

Be described in further details below in conjunction with accompanying drawing:

Figure 1 shows that medicine " osmotic pumps " process units sketch map on the bubble-cap formula packer

Figure 2 shows that the horizontal sketch map in A--A place

Figure 3 shows that medicine " osmotic pumps " mould shape sketch map

As shown in the figure, the system bubble-cap is shaped to finishing die 3 after preheater 2 preheatings with PVC or pp film rolling 1, both make the filling medicine and made bubble-cap, the container film 4 that has formed bubble-cap is transported to dispenser 6 places through by-pass roll 5, the semipermeable membrane coating body of having wrapped 13 is housed in the dispenser 6 also to be inserted this semipermeable membrane coating body 13 in the bubble-cap by grain, lack sheet checkout gear 7 through first, second lacks sheet checkout gear 8 detects, give 9 one of perforating devices and the corresponding pulse signal of its conveying spacing when confirming intact, the semipermeable membrane coating body 13 that is opposite in the bubble-cap punches, perforating device 9 can be laser, machinery (or other) perforating device, first, second lacks sheet checkout gear 7,8 respectively or be that photoelectricity or contact pin type lack the sheet checkout gear or other form lacks the sheet checkout gear, subsequently, the aluminium foil of being supplied with by aluminum foil coil 10 rolls 11 through transition and seals to decorative pattern sealing plate 12 places, above-mentioned first lack sheet checkout gear 7 and second lack sheet checkout gear 8 by " with " mode is connected, promptly lacking has one group to predict when lacking sheet in the sheet checkout gear, perforating device 9 also is failure to actuate, the semipermeable membrane coating body 13 that not punch because of perforating device 9 does not move this moment is discharged after heat-sealing automatically, put into dispenser again and repeat said process, to sum up easily see, this utility model has utilized all kinds of bubble-cap formula packer packing tablet counters exactly, the drug coating body is at corresponding bubble-cap on the multiclass machines such as sugar-coat ink writer, naturally localized fundamental characteristics in mould and the delivery track, by drug release feature laser is set, the device of machinery or other dozen release, to simplify the production process of making medicine " osmotic pumps " small delivery aperture of being beaten, be adapted to the big purpose of producing of medicine " osmotic pumps " to reach.

Claims

1, utilizes the machine have delivery track or conveying, counting orifice or shaping, delivery mold to settle the process units of a kind of medicine " osmotic pumps " of perforating device, it is characterized in that lacking that sheet checkout gear 7, second lacks sheet checkout gear 8, perforating device 9, semipermeable membrane coating body 13 and film rolling 1, preheater 2, aluminum foil coil 10, transition is rolled 11 each diamond plate 12 and formed by the container film 4, by-pass roll 5, the dispenser 6, first that become mould 3, formed bubble-cap.

2, it is characterized in that by the described device of claim 1 semipermeable membrane coating body 13 is made up of medicine 14, semipermeable membrane coatings 15 and small delivery aperture 16.

3, it is characterized in that by the described device of claim 1 perforating device 9 can use laser boring, mechanical punching or other hole knockout, punching frequency per minute is less than 300 times.

4, by the described device of claim 1 it is characterized in that first lack sheet checkout gear 7, second lack sheet checkout gear 8 can be respectively photo-electric and contact pin type lack sheet checkout gear (or being all a kind of form) and the two with " with " mode is connected.

5, it is characterized in that institute's eyeletting diameter between 5 μ m--2mm by claim 1, described device, the number that at every turn punches is at the 1--20 grain.

6, it is characterized in that entering in the thin film 4 that forms bubble-cap and it is fed forward by the described device of claim 1 through dispenser 6, semipermeable membrane coating body 13.