CN208516224U - Low temperature sample access arrangement - Google Patents

Abstract

The utility model provides a kind of low temperature sample access arrangement comprising :-sample layer frame, layer frame inside keep low temperature environment, are time low temperature environment outside layer frame, sample layer frame is exported equipped at least one；It is used for the sample load plate of sample loading container, including the first magnet；The load plate transport device being located at outside layer frame, including removable motion block and its driving device, removable motion block has the second magnet, second magnet can be generated with the first magnet it is contactless attract each other, driving device can drive removable motion block to move along layer frame outer surface and drive load plate to move inside layer frame by described attract each other；Control system is able to record the position of sample load plate and controls the movement of removable motion block.In the sample access arrangement of the utility model, mechanical moving element is all in time low temperature environment, reduces the generation of failure.Meanwhile machine can be overhauled under secondary low temperature, the environment temperature without influencing storage sample.

Description

Low temperature sample access arrangement

Technical field

The utility model relates to life sciences, and in particular, to a kind of low temperature sample access arrangement and be set using this The standby method that low temperature sample is stored and taken out.

Background technique

Biological sample is extremely valuable scientific research resource, and sample database is mainly Collection and conservation different kind organism sample, than Such as blood, urine, saliva, tissue, cell are to carry out accurate medicine, conversion to meet clinical diagnosis and treatment and scientific research demand The core link of medical research.

Traditionally, biological sample is stored in cryopreservation tube, is had a unique bar code above each cryopreservation tube, is convenient for Inquiry, tracking sample, guarantee the safety of sample, are then placed into freezing storing box, and some position for being put into refrigerator is protected It deposits.

This traditional storage mode is easy fault in management, such as when sample goes out and is put in storage, in order to choose a sample It needs whole box sample all to take out, leads to multiple switching refrigerator doors, so that the temperature in refrigerator and unstable, be easy to cause sample This quality dissatisfaction；Or the sample of multiple departments all exists together, it be according to status and future development come allocation space, distribution Permission etc..And phenomena such as generally existing sample data is imperfect, quality dissatisfaction, severely impact correlative study result Reliability.Therefore, up-to-standard, the complete biological sample of data is efficiently obtained and stores, making it more effectively is that medicine is big Data research service becomes as the key of biological industry development.

Sample is accessed from low temperature environment at present mainly mechanical movement and pneumatic transfer two ways.Mechanical motion mode Mainly sample is stored in the container of fixed shape, is put into or takes out at low ambient temperatures container using mechanical arm, so By required sample, picking is come out out of fixed container in the environment of secondary low temperature afterwards, then the container that will contain unwanted sample It is put back into storage in low temperature environment.Pneumatic transfer mode mainly passes through positive pressure or negative pressure and the sample under low temperature environment is passed through gas Pipeline is transmitted to fixed container, to realize the taking-up and storage of sample in the case where not using mechanical movement.

Due to Sample preservation temperature at -70 DEG C hereinafter, even up to -196 DEG C, using mechanical fortune under this low temperature environment The main problem of flowing mode access sample is that mechanical moving element is directly exposed in low temperature environment, the low temperature tolerants such as motor Property difference component situations such as being easy to appear motion control failure or sensor fault, cause machine to be unable to operate normally.And it deposits It is expensive to store up equipment, structure is complicated, and mechanical moving element once breaks down, and to the more demanding of maintenance, maintenance process is also very multiple Miscellaneous, the low temperature environment where sample has been easy larger temperature fluctuation, has a certain impact to the preservation of stablizing of sample.

Although and storing sample not complicated mechanical moving element, flue at low ambient temperatures using pneumatic transfer Road is higher to the geomery and coherence request of sample container, is not suitable for the diversified storage of sample container type.

Meanwhile more than the existing millions of RMB of sample storage device single device, price is extremely high, separate unit storage Sample size tens of thousands of to 200,000.Since storage equipment unit price is high, disaster recovery backup ability is limited, once equipment occurs Failure can only wait the maintenance of profession, and sample transfer processing process is cumbersome, higher to the requirement of user.

Utility model content

The utility model is intended to provide that a kind of reliability is higher, smaller automation low temperature sample is influenced on storage environment deposits Take equipment.

For this purpose, the utility model provides a kind of low temperature sample access arrangement comprising:

Sample layer frame, layer frame inside keep low temperature environment, are time low temperature environment outside layer frame, sample layer frame is equipped at least One outlet, each exit are equipped with openable and closable hatch door；

It is used for the sample load plate of sample loading container, including the first magnet, is located inside layer frame in storage state, and Sample layer frame can be passed in and out from the outlet；

The load plate transport device being located at outside layer frame, including removable motion block and its driving device, removable motion block have second Magnet, second magnet can be generated with the first magnet it is contactless attract each other, driving device can drive removable motion block It is moved along layer frame outer surface and drives load plate to move inside layer frame by described attract each other；

Control system is able to record the position of sample load plate and controls the movement of removable motion block.

In the sample access arrangement of the utility model, mechanical moving element is all in (- 40 DEG C of room temperature or secondary low temperature environment Or more, preferably -20 DEG C or more) in, and low temperature environment (- 70 DEG C and less) or ultra-low temperature surroundings (- 196 DEG C and with Under) in there is no any mechanical moving element.The low-temperature pressure that the core components such as motor, sensor are born as a result, is smaller, reduces The generation of failure.Meanwhile even if breaking down, Quick overhaul can also be carried out to machine under secondary low temperature or normal temperature environment, and It does not influence to store the low temperature of sample or the temperature of ultra-low temperature surroundings.The utility model can be widely used in laboratory, therapeutic machine The sample low temperature of structure stores, and by multiple parallel connections, realizes the disaster recovery backup ability of height.

The utility model can be passed through the dry gas (such as compressed air or high pure nitrogen) of low dew point in low temperature environment, It keeps in the low temperature environment without condensation vapor.

The sample access arrangement can also include one or more of following characteristics, and can be used alone or combine makes With:

The equipment includes multiple sample layer frames, stacked on top of each other or be arranged side by side to constitute the bigger sample of capacity and deposit Store up space.Low temperature environment inside each sample layer frame can be the same or different, can be by unified low-temperature control system Control, can also each layer frame be equipped with individual low-temperature control system, the low-temperature control system can be with aforementioned control system For same system, it is also possible to control system independent of each other.Preferably, the outlet of each sample layer frame is located at sample layer frame Side or top surface, convenient for the disengaging of sample load plate.

The sample layer frame is hollow box body, and the box body wall for separating the first magnet and the second magnet is set as multilayered structure, Including two layers of demagnetization material layer and sandwiched vacuum layer therein, demagnetization material layer towards be covered on the face outside box body wall every Hot material layer, it is preferable that demagnetization material layer towards being again covered with insulation material layer on the face inside box body wall.The work of vacuum layer With being to obstruct heat transfer, without interfering attracting each other for the first magnet and the second magnet.And the wall as cabinet is main Material, demagnetization material layer provide rigid structure for cabinet, while not interfering attracting each other for magnet.Demagnetization material layer is for example For demagnetization stainless steel layer, with a thickness of 1-2mm.Preferably, insulation material layer is layer of nanomaterial, e.g. passes through the wear-resisting place of antirust The layer of nanomaterial of reason.The integral thickness of box body wall e.g., less than or equal to 15mm is preferably set to 3 between 8mm.

The sample load plate is equipped with auxiliary moving device, to reduce frictional resistance when load plate moves in layer frame, with side Just movement of the sample container of load plate and its loading in sample layer frame.The auxiliary moving device is, for example, scroll wheel, preferably For universal wheel.

The sample container that the sample load plate can load includes the reagent bottle and test tube of various sizes, such as by holding Standard multi-well disk or deep hole disk are carried to load said vesse.

Second magnet can switch between configuration attracting configuration and releasing to attract, it is preferable that the second magnet has Upper and lower two attraction configuration.When removable motion block is aligned with mobile load plate is needed, then the second magnet is placed in attraction configuration, with load First magnet of disk, which generates, to be attracted and thus load plate is driven to move in layer frame.When removable motion block does not need to drive load plate mobile When, then the second magnet is placed in releasing and attracts configuration, then removable motion block can move freely outside layer frame without in movement It is unexpected in the process to attract any load plate being located inside layer frame.When removable motion block is located between two sample layer frames, setting the Two magnets can be flipped up or downwardly turn over, then can be driven by the same removable motion block in two layer frames up and down Load plate it is mobile, obtain the effect for saving equipment.

The equipment includes multiple horizontal and stacked in parallel with each other sample layer frame, arranges one within each sample layer frame The layer sample load plate or the sample load plate for being separated and being stacked for two layers arrange multiple samples in every layer in an array manner The position of this load plate and at least one vacant sample load plate.For example, sample layer frame and sample load plate be all at substantially rectangular shape, Sample load plate is arranged in layer frame in an array manner.The position of at least one hollow remaining load plate of array is for convenience by institute Each load plate of rearrangement when load plate being needed to remove, i.e., be set to transfer position with the spare bits, gradually moves each load plate and passes through the position It replaces, required load plate is moved to outlet.When only arranging one layer of load plate in sample layer frame, load plate can such as band There is the first magnet arranged downward, while removable motion block is set and is located at except the lower surface of layer frame, the attraction structure of the second magnet Type be it is upwardly disposed, attracted each other with the first magnet with load plate.Can certainly arrange on the contrary or load plate upward downward It is equipped with the first magnet.When load plate has the first upwardly disposed magnet, load plate can be for example including first upwardly extended Magnet rigid support, the height of bracket be arranged so that the upper wall of the close enough layer frame of the first magnet with second outside layer frame Magnet generation attracts each other.

In one embodiment, internal only to arrange that two adjacent sample layer frames of one layer of sample load plate are seamless each other Ground is stacked, and is located above the load plate in layer frame with the first upwardly disposed magnet, is located below the load plate in layer frame with court First magnet of lower arrangement, it is preferable that load plate has the first magnet up and down.I.e. two adjacent sample layer frames can stack, this The advantages of kind embodiment, is that space can be saved, while identical low temperature ring is necessarily kept in two adjacent sample layers Border.

Similarly, when the sample load plate, which is arranged as two layers, to be stacked within same sample layer frame, the load plate band on upper layer There is the first upwardly disposed magnet, the load plate of lower layer has the first magnet arranged downward, it is preferable that load plate is up and down with the One magnet.It should be appreciated that in this arrangement, being separated between two layers of sample load plate with rigid wall.When load plate is equal up and down With the first magnet, it is every magnetic that the rigid wall, which can be set,.

In one embodiment, load plate transport device is arranged between the sample layer frame that two adjacent and non-seamless is stacked Y-direction guide rail, the X direction guiding rail and at least one removable motion block that can be slided along Y-direction guide rail, removable motion block is under the drive of the drive It is slided along X direction guiding rail.Thereby, it is possible to realize the movement of removable motion block in the x-direction and the z-direction.Of course, it is possible to using any energy The driving device that removable motion block is moved along layer frame outer surface is enough controlled, such as motor driven directly is set on removable motion block, or It is driven by cylinder.Meanwhile when load plate has the first magnet up and down, can and non-seamless adjacent in any two it is stacked It is respectively provided with removable motion block between sample layer frame, can also only be arranged between the layer frame of needs.For example, when in several adjacent layer frames It, can be only when the second magnet that portion only arranges that one layer of sample load plate and removable motion block have has two attraction configurations up and down Removable motion block is set in odd number layer frame interval, and is not provided in even number layer frame interval, or on the contrary, between the layer frame Every referring to the gap between adjacent layer frame.

In one embodiment, the load plate transport device includes the vertical Z axis that can be moved along Y-direction guide rail and can edge The X direction guiding rail that Z axis is moved in a straight line and made rotating motion about the z axis, the removable motion block can be under the drive of the drive along X Direction guiding rail sliding.In this arrangement, the structure of transport device more simplifies, and the removable motion block of negligible amounts can be set, and It allows them to move in different layer frame intervals.Specifically, X direction guiding rail can be slided up and down along Z axis, thus, it is possible to from The side of layer frame navigates between different layer frames, and then X direction guiding rail is rotated to about the z axis in layer frame interval, and removable motion block is just located It can move in layer frame interval and in X direction；Meanwhile Z axis can slide again along Y-direction guide rail, removable motion block can lead to as a result, Arbitrary plane movement is completed in the movement for crossing X-direction and Y-direction.

Another aspect according to the present utility model additionally provides a kind of above-mentioned sample access arrangement of utilization from low temperature environment The method for taking out sample, includes the following steps:

A- is received the instruction for taking out certain sample by control system, determines sample layer frame and sample load plate where the sample；

B- drives removable motion block, the mutual suction for the first magnet that the second magnet having by it and sample load plate are had Draw, and the sample load plate is moved to the outlet of the sample layer frame；

C- opens hatch door, takes out sample tray or directly takes out the sample.

In the method, mechanical moving element all operation and movements in secondary low temperature environment, farthest reduce It is exposed to duration in low temperature environment and thus bring damage risk.Meanwhile sample in moving process still in sealing Low temperature environment in, heat does not occur with external environment and exchanges, it is possible thereby to farthest reduce sample due to temperature change And rotten risk occurs.

When accommodating multiple sample load plates in the sample layer frame, it can be envisaged that above-mentioned steps A includes calculating to remove path Step.The calculating removes the step of path by control system execution operation program to realize.And work as sample load plate in the form of an array When being arranged in sample layer frame and reserving vacant position, wherein step B including the use of every layer of sample load plate vacant position by certain A little sample load plates rearrange position, attract these sample load plates using removable motion block and are moved into calculated position On, and record the new position.The step of sample load plate is moved to new position may be repeated, until mobile load plate will be needed It is all moved to the position calculated in step A and required load plate is moved to exit.

In the present invention, term " sample " refer to include the bioactive substance to be extracted ingredient, such as blood Liquid, urine, saliva, tissue, cell etc..

Detailed description of the invention

The utility model is described in further detail below with reference to accompanying drawings.Skilled addressee readily understands that It is that these attached drawings are intended solely for illustrative purposes, and are not intended to and are construed as limiting to the protection scope of the utility model.Phase in figure Same appended drawing reference indicates the same or similar component.For illustrative purposes, these figures and non-fully drawn to scale.

Fig. 1 is It clearly shows that its internal construction, the roof of the sample layer frame of the top is not shown in the figure.

Fig. 2 schematically shows multiple samples in the low temperature sample access arrangement according to another embodiment of the utility model The arrangement of this layer frame, wherein load plate transport device is omitted.

Fig. 3 is the structural schematic diagram according to the wall of the sample layer frame of the utility model one embodiment.

Fig. 4 is the schematic face upwarding stereogram according to the sample load plate of the utility model one embodiment.

Fig. 5 is the stereoscopic schematic diagram according to the sample load plate of the utility model another embodiment.

Fig. 6 is according to the stereoscopic schematic diagram of the load plate transport device of the utility model one embodiment, wherein sample is omitted This layer frame.

Fig. 7 is according to the stereoscopic schematic diagram of the load plate transport device of the utility model another embodiment, wherein being omitted Sample layer frame.

Fig. 8 is the stereoscopic schematic diagram according to the removable motion block of the utility model one embodiment.

Specific embodiment

Firstly, being described with reference to Figure 1 whole according to the low temperature sample access arrangement of the utility model one embodiment.This is low Warm sample access arrangement 1 include multiple sample layer frames 10, they are horizontal and are stacked in parallel with each other, between adjacent layer frame 10 there are Interval 12.Each layer frame 10 includes at least one outlet 14, such as is located at the side of layer frame as shown in the figure, and exit is equipped with and can beat Open and close hatch door 16, to keep keeping inside layer frame low temperature environment, such as -70 DEG C and hereinafter, even -196 DEG C and less. It and is time low temperature environment outside layer frame, such as -40 DEG C or more, even -20 DEG C or more.

It can be seen that multiple sample load plates 20, Mei Gezai from the sample layer frame 10 that roof is not shown of the top in Fig. 1 Disk can carry one or more sample container (not shown), or by sample tray (such as standard multi-well disk or deep hole disk, not Show) load said vesse.In this example, load plate 20 is generally rectangular shaped, is arranged in the inside of layer frame 10 in an array manner, Thus sample is stored in low temperature environment.In an array, there are several vacant positions 22, each load plate 20 is moved to specified to facilitate Required load plate is simultaneously moved at outlet 14 by position, and specific move mode will be described later.

Load plate transport device 30, referenced in schematic XYZ coordinate axis are also shown in Fig. 1 comprising along the support of Z-direction setting Part 46, multiple Y-direction guide rails 42 being fixed on supporting element 46 and can be along the X direction guiding rail 44 that Y-direction guide rail moves.Wherein, each Y-direction Guide rail 42 is all located in z-direction at the interval 12 of sample layer frame 10, so that each X direction guiding rail 44 is extend into interval 12.Knot Close Fig. 6 and Fig. 8, it can be seen that each X direction guiding rail 44 is equipped with a removable motion block 32, (is not shown, example in driving device Such as motor) driving under moved along X direction guiding rail 44.Thereby, it is possible to realize the movement of removable motion block 32 in the x-direction and the z-direction. The length of X direction guiding rail 44 and Y-direction guide rail 42 is arranged so that the range covering sample that removable motion block 32 moves in layer frame interval 12 The range of sample load plate 20 is disposed in this layer frame 10.It can be seen that load plate transport device 30 is entirely located at outside layer frame, by This is damaged from being placed in low temperature environment, so that the reliabilty and availability of equipment is provided, simultaneously because transport device 30 each component need not resist low temperature, can save cost of equipment to a certain extent.

Another arrangement of sample layer frame 10 is shown in Fig. 2, in order to clearly show that, wherein sample load plate is omitted With load plate transport device.It can be seen in fig. 2 that some layer frames 10 are stacked two-by-two and centre leaves no gaps.In this way, layer frame interval 12 is just Not it is present between all adjacent sample layer frames 10, but exists only between two-by-two stacked layer frame group 10 ' or layer frame Between group 10 ' and individual layer frame 10.It, can be with layer but in order to from the outside of layer frame 10, especially upper surface or lower surface The magnet of load plate 20 inside frame 10 generates attraction, and at most two layer frames 10 of setting are stacked on top of each other in the vertical direction, and cannot More.Certainly, multiple sample layer frames can be set in the same horizontal position.In embodiment described in Fig. 2, it is envisaged that only Removable motion block is equipped in the interval of layer frame group 10 ' 12.

It is also assumed that another arrangement of sample layer frame 10, i.e., in same sample layer frame 10, in setting As described above with the sample load plate 20 of array arrangement, the vacant position of at least one sample load plate is all reserved in every layer lower two layers 22, it is separated with rigid wall between two layers.

In two kinds as above arrangements, in the top layer frame of seamless stacked layer frame group 10 ' or it is located on the same floor frame The load plate 20 of 10 inside upper layer has the first upwardly disposed magnet 24 ', and is located at the lower section of seamless stacked layer frame group 10 ' In layer frame or the load plate 20 of 10 inside lower layer of frame is located on the same floor then with the first magnet 24 arranged downward.Preferably, load plate About 20 have the first magnet 24,24 ', as shown in Figure 5.

Similarly, in above two arrangement, for being all the removable motion block 32 of the double-deck load plate, the second magnet 34 up and down Tool there are two attract configuration, that is, can it is upwardly disposed with attract lower layer's load plate the first magnet 24 and downward arrange with attract The construction and configuration of removable motion block 32 will be described in more detail below in first magnet 24 ' of upper layer load plate.

The structure of the wall 50 of sample layer frame 10 is described below with reference to Fig. 3.As shown in Figure 1, sample layer frame 10 is hollow box Body, has the substantially global shape of cuboid and thus there are six faces for tool.In embodiments herein, by its lower surface And/or upper surface separates the first magnet 24 of sample load plate 20 and the second magnet 34 of removable motion block, for this or two Face, box body wall 50 are set as multilayered structure, include mainly two layers of demagnetization material layer 52 and sandwiched vacuum layer therein 54, and disappear Flux material layer 52 towards being covered with insulation material layer 56 on the face outside box body wall.Vacuum layer 54 can obstruct heat transfer, and It will not interfere attracting each other for the first magnet 24 and the second magnet 34.And the main material as the wall of cabinet 50, demagnetization material Layer 52 provides rigid structure for cabinet, while not interfering attracting each other for magnet 24,34.Demagnetization material layer 52 is, for example, to disappear Magnetic stainless steel layer, with a thickness of 1-2mm.But those skilled in the art can select other demagnetization metals or other according to actual needs Demagnetization material constitutes the layer 52, (such as number, capacity and predicted weight of sample) can also be arranged according to actual needs Its thickness.In the present embodiment, insulation material layer 56 is layer of nanomaterial, e.g. the nano material Jing Guo antirust Wear-resistant Treatment Layer.Preferably, demagnetization material layer 52 towards being again covered with insulation material layer on the face inside box body wall.

Fig. 4 and Fig. 5 respectively illustrates a kind of embodiment of sample load plate 20.Fig. 4 is that sample load plate 20 looks up solid Figure, it is seen that be mounted on four the first magnets 24 of 20 bottom surface medium position of load plate, and be mounted on the four rolling of bottom surface quadrangle 26.In the present embodiment, idler wheel 26 is all universal wheel.Certainly, the position and quantity of the first magnet 24 and idler wheel 26 be all can be with Variation.In addition, being also shown load plate 20 includes sample accommodating area 21, that is, store the region of sample container.The sample accommodating area 21 The pallet (such as standard multi-well disk or deep hole disk, be not shown) that sample container can be carried, can also be directly disposed as and sample The matched card hole of container shapes, so that sample container is firmly attached to sample load plate 20 in accommodating area, even if carrying in sample When disk 20 is mobile.

Load plate 20 in Fig. 5 is similar with shown in Fig. 4, also includes the first magnet 24 and the setting being arranged in the middle part of bottom surface Idler wheel 26 in bottom surface quadrangle.In addition, in the present embodiment, load plate 20 further includes the rigid support 25 upwardly extended, thereon table The first upwardly disposed magnet 24 ' is arranged in face, and the height of bracket 25 is arranged so that the close enough layer frame 10 of the first magnet 24 ' Upper wall 50, to attract each other with the second magnet 34 generation outside layer frame 10.

It is of course also possible to which it only includes the first upwardly disposed magnet 24 ' that load plate 20, which is arranged,.

When load plate 20 only includes the first magnet 24 arranged downward, then in seamless stacked layer frame group 10 ' or content bilayer In the layer frame 10 of load plate, lower layer can only be placed it in；Equally, when load plate 20 only include the first upwardly disposed magnet 24 ', then exist In seamless stacked layer frame group 10 ' or the layer frame 10 of content bilayer load plate, upper layer can only be placed it in.And if load plate 20 both wrapped The first magnet 24 arranged downward is included, and including the first upwardly disposed magnet 24 ', then in above-mentioned layer frame arrangement, can incited somebody to action It is placed in upper layer or lower layer.

Load plate transport device 30 according to the present utility model is described below with reference to Fig. 6 to Fig. 8.Load plate in Fig. 6 transports dress It sets similar in Fig. 1, does not repeat.The load plate transport device according to the utility model another embodiment is shown in Fig. 7 30 comprising can move in a straight line along the mobile vertical Z axis 46 ' of Y-direction guide rail 42 ' and along Z axis 46 ' and 46 ' do and revolve about the z axis The dynamic X direction guiding rail 44 ' of transhipment, removable motion block 32 can be moved along X direction guiding rail 44 ' under the drive of the drive.In diagram In example, the quantity of X direction guiding rail 44 ' is two, and the X direction guiding rail 44 ' of top rotates to X-direction, so that removable motion block 32 is located at Between layer frame (not shown)；And the X direction guiding rail 44 ' of lower section rotates to Y-direction, so that removable motion block 32 is located at except layer frame, i.e., Positioned at off-position.As can be seen that guide rail quantity in Fig. 7 greatly reduces compared with load plate transport device shown in fig. 6, Thus the structure of transport device more simplifies, and the removable motion block of negligible amounts can be set, and allows them in different layers Frame moves in interval.The quantity of certain X direction guiding rail 44 ' can change.Specifically, X direction guiding rail 44 ' can be along Z axis 46 ' It slides up and down, thus, it is possible to be navigated between different layer frames from the side of layer frame, the then 46 ' rotation about the z axis of X direction guiding rail 44 ' Into layer frame interval, removable motion block 32 is in layer frame interval and can move in X direction；Simultaneously or sequentially, Z axis 46 ' can slide along Y-direction guide rail 42 '.Removable motion block can complete arbitrary plane shifting by the movement of X-direction and Y-direction as a result, It is dynamic.

Fig. 8 shows the removable motion block 32 according to the utility model one embodiment, is connected by the sliding of attachment device 36 It is connected on X direction guiding rail 44.Removable motion block 32 includes main body 38 and the second magnet 34 being arranged in main body 38.In the present embodiment The quantity of second magnet 34 be two, two the first magnets 24 that the two distance is had with sample load plate 20 be equidistant or It is almost equal.Removable motion block 32 further includes for making the second magnet 34 attract configuration and release what is switched between attraction configuration to cut Changing device 35.Specifically, in the present embodiment, which is rotating device, main body 38 can be rotated 180 °, made Its upper attraction configuration for being sequentially located at diagram, the releasing being rotated by 90 ° attract configuration and rotate 180 ° of lower attraction configuration.When Removable motion block 32 is aligned with mobile load plate is needed, then the second magnet 34 is placed in attraction configuration, the first magnet with load plate 20 24 generate attraction and thus load plate 20 are driven to move in layer frame 10.When removable motion block 32 does not need to drive load plate mobile, then Second magnet 34 is placed in releasing and attracts configuration, then removable motion block can move freely outside layer frame 10 without being moved through Any load plate 20 of the unexpected attraction potential inside layer frame 10 in journey.When removable motion block 32 is located between two sample layer frames 10, The second magnet 34, which is arranged, can be flipped up or downwardly turn over, then can be driven by the same removable motion block 32 up and down Load plate 20 in two layer frames 10 is mobile, obtains the effect for saving equipment.It should be appreciated that quantity and the setting side of the second magnet 34 Formula is corresponding with the first magnet 24, is that those skilled in the art can select according to the actual situation.

According to another embodiment, switching device 35 is minitype cylinder, and the second magnet 34 can be pushed in main body 38 Inside lifting, to realize attraction and release attraction configuration.In this embodiment, consider pushing away the setting of the second magnet 34 On block, pushing block releases main body 38 by minitype cylinder to reach attraction configuration, and withdraws within main body 38 and just reach releasing attraction structure Type.The second magnet can be arranged up and down in pushing block, to realize two attraction configurations up and down.

The method of operation of low temperature sample access device according to the present utility model is described below.Utilize above-mentioned low temperature sample Access device carries out following steps:

A- by control system receive take out certain sample instruction, and according to the record currently to sample load plate array position come Determine the sample layer frame 10 and sample load plate 20 where the sample；

B- controls driving device to drive removable motion block 32 corresponding with the sample layer frame 10, by its sky by control system The position for being moved to and needing outside layer frame 10 corresponding to mobile sample load plate 20 is sailed, is had in empty driving moving process The second magnet 34 be switched to releasing attract configuration；After movement in place, second magnet 34 is cut by configuration switching device 35 Attraction configuration is changed to, is attracted each other with the first magnet 24 being had with sample load plate 20 across the wall 50 of layer frame 10；Again by controlling System processed controls driving device to drive removable motion block 32, so that the sample load plate 20 to be moved to the outlet of the sample layer frame 10 14；

C- opens hatch door 16, takes out sample tray using mechanical arm or directly takes out the sample.

In the method, mechanical moving element all operation and movements in secondary low temperature environment, farthest reduce It is exposed to duration in low temperature environment and thus bring damage risk.Meanwhile sample in moving process still in sealing Low temperature environment in, heat does not occur with external environment and exchanges, it is possible thereby to farthest reduce sample due to temperature change And rotten risk occurs.

When accommodating multiple sample load plates in the sample layer frame, it can be envisaged that above-mentioned steps A includes calculating to remove path Step.The calculating removes the step of path by control system execution operation program to realize.

By taking Fig. 1 as an example, it is assumed that the sample load plate for needing to remove is 202, and using in Fig. 1 load plate transport device (i.e. by Frame that supporting element 46, Y-direction guide rail 42 and X direction guiding rail 44 are constituted) operation for being moved load plate 202 is executed, then counting Calculate path the step of include X direction guiding rail 44 is slided into Y-direction position Y1 corresponding to load plate 202 in Y-direction guide rail 42, and Removable motion block 32 is moved to X-direction position X1 corresponding to load plate 202 in X direction guiding rail 44, and after being attracted to load plate 202 It is moved into this series of steps of outlet corresponding X-direction position X2 and Y-direction position Y2.Certainly, if using other The transport device of mode, such as directly drive removable motion block 32 with linear motor, then removable motion block 32 need not along the X direction and Y Direction movement, but can be moved any direction along X/Y plane, then the step of calculating path may include to shortest path The calculating of diameter, and verify whether can execute the path and without impinging on obstacle.

And when sample load plate is arranged in sample layer frame in the form of an array and reserves vacant position, above-mentioned steps B includes Certain sample load plates are rearranged into position using the vacant position of every layer of sample load plate, attract these samples using removable motion block Load plate and be moved on calculated position, and record the new position.The step of sample load plate is moved to new position can Repeat, until mobile load plate will be needed all to be moved to the position calculated in step A and be moved to out required load plate At mouthful.

Still by taking Fig. 1 as an example, in the array that the sample load plate shown in is constituted, one of reserved vacant position is labeled as 220. Assuming that needing for sample load plate 201 to be moved at outlet 14.It can be seen that another sample load plate 202 has blocked the removal of load plate 201 Path.At this moment, it needs using vacant position 220 to remove required sample load come rearrangement sample load plate 202,203 to remove The obstacle of disk 201.Specifically, load plate 203 is first moved to vacant position 220 using removable motion block 32, then 203 original place Position become new vacant position, then load plate 202 is moved to the new vacant position, then 202 it is original where position at For newest vacant position, so that it may which load plate 201 to be moved out at outlet 14.It is contemplated that all recording quilt after movement every time The new position of mobile load plate, in case subsequent calculating uses.

Of course, it is possible to do a variety of variations to the arrangement of layer frame 10 and load plate 20 in the scope of the utility model.For example, pressing According to another embodiment of the utility model, one layer of sample load plate 20, and removable motion block 32 are only arranged inside each layer frame 10 Two attraction configurations up and down can be switched to, then do not need to be designed with removable motion block 32 within each layer frame interval 12, and It is removable motion block 32 only to be set within non-conterminous interval 12, is able to drive two samples above and below the interval 12 Sample load plate 20 within this layer frame 10.Yet another embodiment according to the present utility model, sample that can be shown in Fig. 6 are transported Other Z-direction supporting elements 46 are added in defeated device with the more Y-direction guide rails 42 of fixation, or setting is more in each Y-direction guide rail A X direction guiding rail 44 increases the quantity of removable motion block 32 with this, reaches the efficiency for improving mobile example load plate 20.

Attached drawing and non-limiting specific embodiment foregoing description describe the utility model.In order to instruct inventive principle, It has simplified or omitted some conventional aspects.Those skilled in the art should understand that the modification for being originated from these embodiments falls in this reality With in novel range.Those skilled in the art should understand that features described above can be combined in a variety of ways, with formation, this is practical new Multiple modifications of type.The utility model is not limited to above-mentioned specific embodiment as a result, and only by claim and they etc. Jljl limits.

Claims (15)

1. a kind of low temperature sample access arrangement (1), characterized in that it comprises:

Sample layer frame (10), layer frame inside keep low temperature environment, are time low temperature environment outside layer frame, layer frame is equipped at least one It exports (14), each exit is equipped with openable and closable hatch door (16)；

It is used for the sample load plate (20) of sample loading container, including the first magnet (24), is located in layer frame in storage state Portion, and sample layer frame can be passed in and out by the outlet；

The load plate transport device (30) being located at outside layer frame, including removable motion block (32) and its driving device, removable motion block have Second magnet (34), second magnet (34) can with first magnet (24) generate it is contactless attract each other, it is described Driving device the removable motion block can be driven mobile along layer frame (10) outer surface and by second magnet (34) with it is described Contactless the attracting each other that first magnet (24) generates drives the sample load plate (20) to move inside layer frame；

Control system is able to record the position of sample load plate (20) and controls the movement of removable motion block (32).

2. sample access arrangement (1) as described in claim 1, wherein the equipment includes multiple sample layer frames (10).

3. sample access arrangement (1) as claimed in claim 2, wherein the outlet (14) of each layer frame (10) is located at sample The side or top surface of this layer frame.

4. sample access arrangement (1) as described in claim 1, wherein the sample layer frame is hollow box body, separates the first magnetic The box body wall (50) of body and the second magnet is set as multilayered structure, including two layers of demagnetization material layer (52) and sandwiched vacuum therein Layer (54), demagnetization material layer towards being covered with insulation material layer (56) on the face outside box body wall.

5. sample access arrangement (1) as claimed in claim 4, wherein demagnetization material layer towards on the face inside box body wall It is again covered with insulation material layer (56).

6. sample access arrangement (1) as described in claim 1, wherein the sample load plate is equipped with auxiliary moving device.

7. sample access arrangement (1) as claimed in claim 6, wherein the auxiliary moving device is scroll wheel (26).

8. sample access arrangement (1) as claimed in claim 6, wherein the auxiliary moving device is universal wheel.

9. sample access arrangement (1) as claimed in claim 2, wherein the equipment includes multiple horizontal and folds in parallel with each other The sample layer frame set, the sample for arranging one layer of sample load plate within each sample layer frame or being separated and be stacked for two layers This load plate arranges multiple sample load plates in every layer in an array manner and reserves the vacant position of at least one sample load plate (22)。

10. sample access arrangement (1) as claimed in claim 9, wherein internal two phases for only arranging one layer of sample load plate Seamless unoccupied place is stacked each other for adjacent sample layer frame (10) when constituting layer frame group (10 '), or when the sample load plate is arranged as two stackings When setting within same sample layer frame (10), the load plate in layer is located above in or on layer frame with the first upwardly disposed magnetic Body is located below the load plate in layer frame or in lower layer and has the first magnet (24) arranged downward.

11. sample access arrangement (1) as claimed in claim 10, wherein load plate has the first magnet up and down.

12. sample access arrangement (1) as claimed in claim 2, wherein the load plate transport device is in two adjacent and non-nothings Be arranged between the stacked sample layer frame of seam Y-direction guide rail (42), can along the X direction guiding rail (44) that Y-direction guide rail moves and at least one can Movable block (32), removable motion block (32) are moved along X direction guiding rail under the drive of the drive.

13. sample access arrangement (1) as claimed in claim 2, wherein the load plate transport device (30) includes that can lead along Y-direction The X direction guiding rail for rail mobile vertical Z axis (46 ') and can moving in a straight line along Z axis and making rotating motion about the z axis, it is described removable Motion block can be moved along X direction guiding rail under the drive of the drive.

14. sample access arrangement (1) as described in claim 1, wherein second magnet (34) can attract configuration and It releases to attract and switch between configuration.

15. sample access arrangement (1) as claimed in claim 14, wherein the second magnet (34) has upper and lower two attraction structure Type.