CN208512313U - A kind of multiple stirring liposome processing tank - Google Patents
A kind of multiple stirring liposome processing tank Download PDFInfo
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- CN208512313U CN208512313U CN201820800385.3U CN201820800385U CN208512313U CN 208512313 U CN208512313 U CN 208512313U CN 201820800385 U CN201820800385 U CN 201820800385U CN 208512313 U CN208512313 U CN 208512313U
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- stirring
- tank body
- agitating shaft
- mixing component
- motor
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Abstract
The utility model discloses a kind of multiple stirring liposomes to process tank, belong to liposome preparation apparatus field, it is intended to provide a kind of multiple stirring liposome processing tank, it is insufficient to solve raw material and dispersion liquid stirring, the low problem of liposome formation rate, it is characterized in that, it includes tank body, top cover, feed pipe, agitating device and driving device, top cover is set to above tank body, feed pipe is located on top cover and is connected to tank body, agitating device is connect with driving device, agitating device includes the first mixing component and the second mixing component, driving device includes first motor and the second motor, first mixing component, second mixing component respectively with first motor, the connection of second motor；Tank body lower part is equipped with discharge pipe, and the first mixing component is located in discharge pipe and tank body, and the first mixing component is located at below the second mixing component, and discharge pipe is equipped with discharge port far from the side wall of the second mixing component.The utility model is processed suitable for liposome.
Description
Technical field
The utility model relates to liposome preparation apparatus field, in particular to a kind of multiple stirring liposome processes tank.
Background technique
Liposome has the characteristics that improve curative effect of medication, mitigates adverse drug reaction and targeting as pharmaceutical carrier.
Three during the last ten years, and people have carried out a large amount of research with regard to preparation method.Liposome is to be passed through to dredge in water phase by phospholipid molecule
Water, which acts on, to be formed, and the method for preparation is different, and the partial size of liposome can be from tens nanometers to several microns, and structure also phase not to the utmost
Together.Liposome is just increasingly being taken seriously as a kind of novel drug delivery system.Existing medicinal liposome two-phase point
In arching pushing production process, the raw material and dispersion liquid for needing to mix are stirred.
Notification number is that the Chinese patent of CN203678380U discloses a kind of high sealing liposome processing tank, it includes tank body
With the top cover being arranged in above tank body, the opening of the tank body turns down outward lip, and lip outer ring is evenly equipped with the first groove,
The top cover outer ring is also evenly equipped with the second groove corresponding with the first groove, and the tank body and top cover are each pair of by being entrapped in
Clamp device in first groove and the second groove is tightly connected, and is provided with agitating device, the stirring in the tank body
Device is connected with the driving device outside tank body, and feed opening is offered on top cover.
Although this high sealing liposome processing tank design is rationally, structure is simple, when stirring raw material and dispersion liquid, by
It is fixed in the position of agitating device, raw material and dispersion liquid can only be divided tank interior to be stirred, agitation range is smaller, this is just
Meeting so that in tank body there are still more raw material and dispersion liquid be unable to get it is uniform mix, thus be not easy to be formed be enclosed with it is fat-soluble
The liposome of active ingredient.
Utility model content
The purpose of the utility model is to provide a kind of multiple stirring liposomes to process tank, has the intracorporal raw material of tank and divides
Dispersion liquid is sufficiently stirred, and improves the effect of liposome formation rate.
The above-mentioned technical purpose of the utility model has the technical scheme that
A kind of multiple stirring liposome processes tank, including tank body, top cover, feed pipe, positioned at the intracorporal agitating device of tank and
Driving device outside tank body, the top cover are set to above tank body, and the feed pipe is located on top cover and is connected to tank body,
The agitating device is connect with driving device, and the agitating device includes the first mixing component and the second mixing component, the drive
Dynamic device includes first motor and the second motor, first mixing component, the second mixing component respectively with first motor, second
Motor connection；
The tank body lower part is equipped with the discharge pipe for being connected to and being horizontally arranged with tank body, and the first mixing component level is set
It sets and is located in discharge pipe and tank body, first mixing component is located at below the second mixing component, and the discharge pipe is remote
Side wall from the second mixing component is equipped with discharge port.
By using above-mentioned technical proposal, the work of second the second mixing component of motor driven stirs raw material and dispersion liquid, together
When first motor drive the first mixing component work, stirring be located at tank body lower part raw material and dispersion liquid, stirring sufficiently after at
Product are flowed out from discharge port；First mixing component and the second mixing component collective effect make to stir positioned at the intracorporal raw material of tank with dispersion liquid
It mixes sufficiently, improves liposome formation rate.
Further, first mixing component includes horizontal positioned the first agitating shaft and helical mixing blade；
The helical mixing blade is fixedly connected on the first agitating shaft, side inner wall of the tank body far from discharge pipe
It is equipped with fixed block, first one end of the mixing shaft and fixed block are rotatablely connected, and the other end passes through tank body, discharge pipe and first
Rotor is fixedly connected；
The first motor is fixed on the outer wall of discharge pipe.
By using above-mentioned technical proposal, first motor work, the rotation of first motor rotor drive the first agitating shaft and with
The helical mixing blade rotation being fixedly connected, and then stir the raw material and dispersion liquid for being located at tank body lower part, keep its stirring abundant
Finished product is conveyed to close to discharge port direction simultaneously.
Further, first agitating shaft is equipped with the first stirring frame, and the helical mixing blade is located at the first stirring
In frame, it is symmetrically arranged with the first scraper plate about the first agitating shaft on the outside of first stirring frame, first scraper plate is stirred far from first
The inner wall of the side and discharge pipe of mixing frame contradicts.
By using above-mentioned technical proposal, the first stirring frame and the first scraper plate thereon are rotated with the first agitating shaft, are enhanced
Positioned at the disturbance of the raw material and dispersion liquid of tank body lower part, mixed so that raw material be made to futher stir with dispersion liquid；First scraper plate turns
It is dynamic, make raw material and dispersion liquid be not easy to attach on discharge pipe inner wall, reduces waste.
Further, second mixing component includes the second agitating shaft and mixing part, the second motor fixed setting
Above top cover, the rotor of second motor passes through top cover and is fixedly connected with the second agitating shaft；
The mixing part includes the first stirring blade, the second stirring blade, installation sleeve and coaxially sets with installation sleeve
The stirring ring set, the installation sleeve are fixedly and coaxially connected with the second agitating shaft；
First stirring blade is along installation sleeve outer wall circumference array and is obliquely installed, and the two of first stirring blade
End is fixed with installation sleeve, stirring ring respectively；
Second stirring blade is obliquely installed on the outside of stirring ring and is equipped with several.
By using above-mentioned technical proposal, mixing part is rotated with the second agitating shaft, to the raw material for being located at tank body top and is divided
Dispersion liquid is stirred, the first stirring blade and the second stirring blade be obliquely installed when both being capable of increasing stirring with raw material and dispersion
Contact area between liquid and the disturbance in axial direction can be enhanced, so that raw material and dispersion liquid are stirred more
It is even.
Further, the second stirring blade inclined direction and the first stirring blade inclined direction are opposite.
By using above-mentioned technical proposal, when the first stirring blade and the second stirring blade rotate, their inclined direction
On the contrary, level of disruption when raw material and dispersion liquid stirring is further increased, so that the mixing effect of raw material and dispersion liquid
It is more excellent.
Further, the mixing part is equipped with multiple along the second agitating shaft length direction, and second agitating shaft is equipped with
Several defoaming sticks and between two adjacent mixing parts.
By using above-mentioned technical proposal, defoams stick and rotated with the second agitating shaft, when raw material, dispersion liquid mixing, defoaming
Stick can poke the bubble that raw material, dispersion liquid mixed process generate, and reduce the influence that bubble mixes it, make raw material, dispersion
The mixed effect of liquid is more preferable, to improve the formation rate to liposome.
Further, second agitating shaft is equipped with the second stirring frame, and the mixing part and defoaming stick are located at second and stir
It mixes in frame, is symmetrically arranged with the second scraper plate about the second agitating shaft on the outside of second stirring frame, second scraper plate is far from second
The side of stirring frame and the inner wall of tank body contradict.
By using above-mentioned technical proposal, the second stirring frame and the second scraper plate thereon are rotated with the second agitating shaft, are enhanced
The disturbance of raw material and dispersion liquid mixes so that raw material be made to futher stir with dispersion liquid；The rotation of second scraper plate, makes raw material and dispersion
Liquid is not easy to attach in inner tank wall, reduces the waste of raw material and dispersion liquid.
Further, first scraper plate, the second scraper plate are equipped with resistance to far from the side of the first agitating shaft, the second agitating shaft
Mill pad, the wear-resistant pad are contradicted with discharge pipe, inner tank wall respectively far from the side of the first scraper plate, the second scraper plate.
By using above-mentioned technical proposal, wear-resistant pad can make the first scraper plate, the second scraper plate not with discharge pipe, inner tank wall
It directly contacts, the first scraper plate, the second scraper plate and discharge pipe, tank body is made to be not easily susceptible to damage, to extend the first scraper plate, second
The service life of scraper plate reduces cost.
In conclusion the utility model has the following beneficial effects:
1. passing through the setting of the first mixing component and the second mixing component, can be stirred positioned at the intracorporal raw material of tank with dispersion liquid
It mixes sufficiently, improves liposome formation rate；
2. passing through the setting of the first stirring frame and the first scraper plate, raw material and dispersion liquid can be made to be not easy to attach in inner tank wall
On, reduce waste；
3. can poke bubble by the setting of defoaming stick, the influence that bubble mixes it is reduced, makes raw material, dispersion
The mixed effect of liquid is more preferable.
Detailed description of the invention
Fig. 1 is in the present embodiment for embodying the schematic diagram of tank body, top cover and agitating device positional relationship；
Fig. 2 is in the present embodiment for embodying the signal of the first agitating shaft, the first stirring frame and the first scraper plate connection relationship
Figure；
Fig. 3 is in the present embodiment for embodying the first stirring blade, the second stirring blade, installation sleeve and stirring ring position
The schematic diagram of relationship.
In figure, 1, tank body；11, discharge pipe；111, discharge port；12, fixed block；2, top cover；21, feed pipe；3, it stirs
Device；31, the first mixing component；311, the first agitating shaft；3111, the first stirring frame；3112, the first scraper plate；312, spiral is stirred
Mix blade；32, the second mixing component；321, the second agitating shaft；3211, stick is defoamed；3212, the second stirring frame；3213, it second scrapes
Plate；3214, wear-resistant pad；322, mixing part；3221, the first stirring blade；3222, the second stirring blade；3223, installation sleeve；
3224, ring is stirred；4, driving device；41, first motor；42, the second motor.
Specific embodiment
The utility model is described in further detail below in conjunction with attached drawing.
Wherein identical components are presented with like reference characters.It should be noted that word used in the following description
Language "front", "rear", "left", "right", "up" and "down" refer to the direction in attached drawing, word " bottom surface " and " top surface ", "inner" and
"outside" refers respectively to the direction towards or away from geometric center of specific component.
A kind of multiple stirring liposome processing tank, as shown in Figure 1, including tank body 1, top cover 2, feed pipe 21, agitating device 3
With driving device 4, top cover 2 is set to the top of tank body 1, and feed pipe 21 is equipped with two and is located on top cover 2, two feed pipes 21 with
Tank body 1 is connected to, and agitating device 3, driving device 4 are located in tank body 1, tank body 1 is outer and are connected with each other.Agitating device 3 includes
First mixing component 31 and the second mixing component 32, driving device 4 include first motor 41 and the second motor 42, the first stirring group
Part 31, the second mixing component 32 are connect with first motor 41, the second motor 42 respectively.Raw material and dispersion liquid are fed from two respectively
Pipe 21 enters in tank body 1, and first motor 41, the second motor 42 respectively drive the first mixing component 31,32 work of the second mixing component
Make, stir raw material and dispersion liquid positioned at 1 top and the bottom of tank body can sufficiently.
As shown in Figure 1,1 lower part of tank body is equipped with discharge pipe 11 that is horizontal positioned and being connected to tank body 1, the first mixing component
31 are horizontally disposed with and are located in discharge pipe 11 and tank body 1, and the second mixing component 32, the first mixing component 31 are distributed in upper and lower,
The lower right side side wall of discharge pipe 11 is equipped with discharge port 111, and the liposome formed after raw material and dispersion liquid stirring sufficiently is from out
Material mouth 111 is discharged.
As shown in Figure 1, the first mixing component 31 includes the first agitating shaft 311 and helical mixing blade 312 being horizontally arranged,
Helical mixing blade 312 is fixedly connected on the outer wall of the first agitating shaft 311.The inner left wall of tank body 1 is equipped with fixed block 12,
First motor 41 is fixed on the outer wall on 11 right side of discharge pipe, and the first agitating shaft 311, the axial line of discharge pipe 11 are identical,
First agitating shaft, 311 one end is fixedly connected with 41 rotor coaxial of first motor, and the other end and fixed block 12 are rotatablely connected.Spiral is stirred
It mixes blade 312 to rotate together with the first agitating shaft 311, helical mixing blade 312 is to the raw material and dispersion liquid for being located at 1 lower part of tank body
It is stirred, the two is made to futher stir mixing.
As shown in Fig. 2, to make raw material and dispersion liquid is not easy to attach in discharge pipe 11(referring to Fig. 1) on inner wall, reduce wave
Take, the first rectangular stirring frame 3111 is equipped on the first agitating shaft 311.Helical mixing blade 312 is located at the first stirring frame
In 3111,3111 outside of the first stirring frame is symmetrically arranged with the first scraper plate 3112 about the first agitating shaft 311, the first scraper plate 3112
Outside is equipped with wear-resistant pad 3214, the inner wall conflict of side of the wear-resistant pad 3214 far from the first scraper plate 3112 and discharge pipe 11.
As shown in figure 3, being located at tank body 1(referring to Fig. 1) second mixing component 32 on top includes the second agitating shaft 321 and stirs
Portion 322 is mixed, the second motor 42 is fixedly connected on 2 upper surface of top cover, and the rotor of the second motor 42 passes through top cover 2(referring to Fig. 1)
And be fixedly connected with the second agitating shaft 321, the second agitating shaft 321, the axial line of tank body 1 are identical.
As shown in figure 3, mixing part 322 includes the first stirring blade 3221, the second stirring blade 3222, installation sleeve 3223
And the stirring ring 3224 being coaxially disposed with installation sleeve 3223, installation sleeve 3223 and the coaxial fixed company of the second agitating shaft 321
It connects.First stirring blade 3221 is along 3223 outer wall circumference array of installation sleeve and is obliquely installed, and the one of the first stirring blade 3221
End is fixed with installation sleeve 3223, and the other end and stirring ring 3224 are fixed.Second stirring blade 3222 is along stirring 3224 outer wall of ring
It circumference array and is obliquely installed.The inclined direction of both first stirring blade 3221, the second stirring blade 3222 is opposite.Mixing part
322 rotate with the second agitating shaft 321, to being located at tank body 1(referring to Fig. 1) raw material and the dispersion liquid on top be stirred, to make
The stirring for obtaining raw material and dispersion liquid is more uniform.
As shown in figure 3, there are three mixing part 322 sets along 321 axis direction of the second agitating shaft, two adjacent mixing parts
Two defoaming sticks 3211 for poking bubble are equipped between 322, defoaming stick 3211 is horizontally disposed and fixed with the second agitating shaft 321
Connection.Mixing part 322 and defoaming 3211 periphery of stick are arranged with the second rectangular stirring frame 3212, the second stirring frame 3212 and second
Agitating shaft 321 is fixedly connected, and 3212 outside of the second stirring frame is symmetrically arranged with the second scraper plate 3213, institute about the second agitating shaft 321
State and be equipped with wear-resistant pad 3214 on the outside of the second scraper plate 3213, side of the wear-resistant pad 3214 far from the second scraper plate 3213 and tank body 1(referring to
Inner wall Fig. 1) contradicts.Three mixing parts 322, which are arranged, keeps raw material, dispersion liquid stirring more abundant.
Specific implementation process: raw material and dispersion liquid are passed through two feed pipes 21 first respectively and add tank body 1 by staff
It is interior, start first motor 41, the second motor 42, first motor 41, the work of the second motor 42, the rotation of 41 rotor of first motor later
The first agitating shaft 311, helical mixing blade 312, the first stirring frame 3111 and the rotation of the first scraper plate 3112 are driven, to positioned at tank body
The raw material of 1 lower part is sufficiently stirred with dispersion liquid.It is located at the wear-resistant pad 3214 and discharge nozzle in 3112 outside of the first scraper plate simultaneously
Road 11 contradicts, and scrapes off the attachment on 11 inner wall of discharge pipe.The work of second motor 42, the rotation of 42 rotor of the second motor drive the
Two agitating shafts 321, stirring ring 3224, installation sleeve 3223, the first stirring blade 3221, the second stirring blade 3222, defoaming stick
3211, the second stirring frame 3212 and the rotation of the second scraper plate 3213, the raw material for being located at 1 top of tank body is sufficiently stirred with dispersion liquid
It mixes.The wear-resistant pad 3214 and tank body 1 for being located at 3213 outside of the second scraper plate simultaneously contradict, and scrape off the attachment on 1 inner wall of tank body.It is former
Material and row after dispersion liquid stirring sufficiently at liposome discharge port 111 be discharged, last staff shifts the liposome of acquisition
It is stored to it.
This specific embodiment is only the explanation to the utility model, is not limitations of the present invention, ability
Field technique personnel can according to need the modification that not creative contribution is made to the present embodiment after reading this specification, but
As long as all by the protection of Patent Law in the scope of the claims of the utility model.
Claims (8)
1. a kind of multiple stirring liposome processes tank, including tank body (1), top cover (2), feed pipe (21), it is located in tank body (1)
Agitating device (3) and it is located at the driving device (4) of tank body (1) outside, the top cover (2) is set to above tank body (1), the charging
Pipe (21) is located on top cover (2) and is connected to tank body (1), and the agitating device (3) connect with driving device (4), it is characterized in that:
The agitating device (3) includes the first mixing component (31) and the second mixing component (32), and the driving device (4) includes first
Motor (41) and the second motor (42), first mixing component (31), the second mixing component (32) respectively with first motor
(41), the second motor (42) connects；
Tank body (1) lower part is equipped with the discharge pipe (11) for being connected to and being horizontally arranged with tank body (1), first mixing component
(31) it is horizontally disposed with and is located in discharge pipe (11) and tank body (1), first mixing component (31) is located at the second stirring group
Below part (32), the discharge pipe (11) is equipped with discharge port (111) far from the side wall of the second mixing component (32).
2. the multiple stirring liposome of one kind according to claim 1 processes tank, it is characterized in that: first mixing component
It (31) include horizontal positioned the first agitating shaft (311) and helical mixing blade (312)；
The helical mixing blade (312) is fixedly connected on the first agitating shaft (311), and the tank body (1) is far from discharge pipe
(11) side inner wall is equipped with fixed block (12), and described first agitating shaft (311) one end and fixed block (12) are rotatablely connected, separately
One end passes through tank body (1), discharge pipe (11) is fixedly connected with first motor (41) rotor；
The first motor (41) is fixed on the outer wall of discharge pipe (11).
3. the multiple stirring liposome of one kind according to claim 2 processes tank, it is characterized in that: first agitating shaft
(311) the first stirring frame (3111) are equipped with, the helical mixing blade (312) is located in the first stirring frame (3111), described
It is symmetrically arranged with the first scraper plate (3112) on the outside of first stirring frame (3111) about the first agitating shaft (311), first scraper plate
(3112) inner wall of the side far from the first stirring frame (3111) and discharge pipe (11) contradicts.
4. the multiple stirring liposome of one kind according to claim 3 processes tank, it is characterized in that: second mixing component
It (32) include the second agitating shaft (321) and mixing part (322) that second motor (42) is fixedly installed on above top cover (2), institute
The rotor for stating the second motor (42) passes through top cover (2) and is fixedly connected with the second agitating shaft (321)；
The mixing part (322) include the first stirring blade (3221), the second stirring blade (3222), installation sleeve (3223) with
And the stirring ring (3224) with installation sleeve (3223) coaxial arrangement, the installation sleeve (3223) and the second agitating shaft (321)
It is fixedly and coaxially connected；
First stirring blade (3221) is along installation sleeve (3223) outer wall circumference array and is obliquely installed, first stirring
The both ends of blade (3221) are fixed with installation sleeve (3223), stirring ring (3224) respectively；
Second stirring blade (3222) is obliquely installed on the outside of stirring ring (3224) and is equipped with several.
5. the multiple stirring liposome of one kind according to claim 4 processes tank, it is characterized in that: second stirring blade
(3222) inclined direction and the first stirring blade (3221) inclined direction are opposite.
6. the multiple stirring liposome of one kind according to claim 5 processes tank, it is characterized in that: the mixing part (322) edge
Second agitating shaft (321) length direction be equipped with it is multiple, second agitating shaft (321) be equipped with several defoaming sticks (3211) and position
Between two adjacent mixing parts (322).
7. the multiple stirring liposome of one kind according to claim 6 processes tank, it is characterized in that: second agitating shaft
(321) the second stirring frame (3212) are equipped with, the mixing part (322) and defoaming stick (3211) are located at the second stirring frame (3212)
It is interior, it is symmetrically arranged with the second scraper plate (3213) on the outside of second stirring frame (3212) about the second agitating shaft (321), described second
The inner wall of side and tank body (1) of the scraper plate (3213) far from the second stirring frame (3212) contradicts.
8. the multiple stirring liposome of one kind according to claim 7 processes tank, it is characterized in that: first scraper plate
(3112), the second scraper plate (3213) is equipped with wear-resistant pad far from the side of the first agitating shaft (311), the second agitating shaft (321)
(3214), the wear-resistant pad (3214) far from the first scraper plate (3112), the second scraper plate (3213) side respectively with discharge pipe
(11), tank body (1) inner wall contradicts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820800385.3U CN208512313U (en) | 2018-05-25 | 2018-05-25 | A kind of multiple stirring liposome processing tank |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820800385.3U CN208512313U (en) | 2018-05-25 | 2018-05-25 | A kind of multiple stirring liposome processing tank |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208512313U true CN208512313U (en) | 2019-02-19 |
Family
ID=65340669
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201820800385.3U Expired - Fee Related CN208512313U (en) | 2018-05-25 | 2018-05-25 | A kind of multiple stirring liposome processing tank |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN208512313U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110314574A (en) * | 2019-07-17 | 2019-10-11 | 赵健 | A kind of metallurgical material mixing arrangement |
| CN115414833A (en) * | 2022-11-07 | 2022-12-02 | 中科微针（北京）科技有限公司 | Preparation and defoaming device for viscous solution |
-
2018
- 2018-05-25 CN CN201820800385.3U patent/CN208512313U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110314574A (en) * | 2019-07-17 | 2019-10-11 | 赵健 | A kind of metallurgical material mixing arrangement |
| CN115414833A (en) * | 2022-11-07 | 2022-12-02 | 中科微针（北京）科技有限公司 | Preparation and defoaming device for viscous solution |
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| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
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Granted publication date: 20190219 Termination date: 20210525 |