CN208447588U - A kind of medicative myoelectricity inspection needle of tool - Google Patents
A kind of medicative myoelectricity inspection needle of tool Download PDFInfo
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- CN208447588U CN208447588U CN201721150359.2U CN201721150359U CN208447588U CN 208447588 U CN208447588 U CN 208447588U CN 201721150359 U CN201721150359 U CN 201721150359U CN 208447588 U CN208447588 U CN 208447588U
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- needle
- optical fiber
- myoelectricity
- tubing
- handle
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Abstract
The utility model discloses a kind of medicative myoelectricities of tool to check needle, including needle body and needle handle, needle body one end is fixed in needle handle end, needle body includes housing needle tubing, concentric circles pin electrode and injection needle, and concentric circles pin electrode and injection needle are set in housing needle tubing, and the concentric circles pin electrode includes needle tubing and needle core, the needle tubing is reference electrode, needle core is recording electrode, and needle tubing inner and outer surfaces and needle core surface are equipped with insulating layer, and needle tubing and needle core are separately connected conducting wire inside needle handle；The injection needle connecting conduit, which passes through, to be connect inside needle handle with syringe pump.Drug therapy is carried out to disease sites while the utility model can make medical diagnosis on disease to patient's lesion muscle, improves the therapeutic efficiency and effect of disease.
Description
Technical field
The utility model belongs to medical instruments field, and in particular to a kind of lesion situation for evaluating muscle and has
The myoelectricity of therapeutic effect checks needle.
Background technique
Electromyogram (electromyography) (abbreviation EMG) refers to that applied electronics instrument record muscle is static or receives
Electrical activity and electrical stimulation when contracting check nerve, muscle excitement and conduction function, are that record nerves and muscles bioelectricity is living
A kind of dynamic electrodiagnosis method to judge its function.Generally use two kinds to be traced: one is surface abductions, i.e., electrode
Attach the method for exporting current potential on the skin；Another kind is pin electrode method, i.e., pin electrode is pierced into muscle export local potential
Method.This method can record each action potential of muscle respectively, and according to dynamic from the muscle per second for several times to two, 30 times
Make current potential situation, find the exception of frequency, evaluates the lesion situation of muscle accordingly.
Pin electrode is a kind of common medical energy converter part, and the pin electrode being clinically commonly used includes concentric round needle electricity
Pole, monopolar needle electrode and single fiber pin electrode.Concentric circles pin electrode is the adapted electrode of electromyograph, is applied to electro photoluminescence inspection
Whether nerve is impaired and damages property and degree, in use, needle body collects patient's flesh in pin electrode needle body insertion patient muscle
Then ultra-weak electronic signal caused by meat contraction passes through conductive electrode and conducting wire is connected to terminal, and doctor is by analysis through handling
The electric signal and waveform crossed diagnoses patient.
Common pin electrode is concentric circles pin electrode, i.e., wears an eradication edge filament, needle casing pack at needle tubing center
Completely insulating materials (such as epoxy resin), then with file the top of needle is filed, so that central wire, which is exposed, is used as contact.Internal thread is general
It is made of nichrome, silver or platinum, diameter about 0.1mm.Needle point is ellipse, and area is 600 μm of 150 μ m.Filament is another
The core wire of terminated coaxial cable, the needle body are connected on the shielding line of coaxial cable.This electrode has shielding action, also referred to as shields
Cover pin electrode.
Current above-mentioned pin electrode can only meet routine clinical detection needs, such as four limbs and trunk compared with big muscle, and for
Head And Face or other lesser muscle, patient does not tolerate inspection generally, and existing pin electrode cannot reflect lesion muscle area chemistry
The change of signal.Due to cannot accurately understand muscle changes situation, common empirical treatment can not provide Individualized program, make
Easily repeatedly at weak curative effect, the state of an illness, clinic diagnosis is influenced.
Summary of the invention
The utility model is in view of the shortcomings of the prior art, provide a kind of can detect the new of chemical signal and electric signal simultaneously
Type myoelectricity checks needle, and determines Muscular pathology variation according to detected signal intensity, gives immunotherapy targeted autoantibody immediately.
The utility model specific technical solution is as follows:
A kind of myoelectricity inspection needle, including needle body and needle handle, needle body one end are fixed in needle handle end, and needle body includes outer casing needle
Pipe, concentric circles pin electrode and injection needle, concentric circles pin electrode and injection needle are set in housing needle tubing, the concentric round needle electricity
Pole includes needle tubing and needle core, and the needle tubing is reference electrode, and needle core is recording electrode, and the needle tubing and needle core are separately connected conducting wire
Through connecting inside needle handle with electromyogram and evoked potentuial measuring system, the needle tubing inner surface and needle core surface are equipped with insulating layer, described
Injection needle connecting conduit, which passes through, to be connect inside needle handle with syringe pump.
Preferably, on the needle tubing inner surface insulating layer and/or needle core surface insulation layer of the concentric circles pin electrode or needle
It is equipped with one or several ion-selective microelectrodes between pipe internal surface insulating layer and needle core surface insulation layer and/or optical fiber is visited
Needle, the ion-selective microelectrode have head end and end, and head end receives ion concentration variable signal, and end connecting wire is worn
It crosses inside needle handle and is connect with potentiometer；The optical fiber probe has head end and end, and head end detects chemical substance signal, and end exists
It couples and connects inside needle handle or inside needle handle with the output optical fiber, the output optical fiber is connect with spectrometer；Or the light
Fine probe end is coupled and is connect with incident optical and the output optical fiber inside needle handle or inside needle handle, incident optical and light source
Generator connection, the output optical fiber are connect with spectrometer.
Preferably, the ion-selective microelectrode and/or optical fiber nano-probe are axially distributed along needle body.
Ion-selective microelectrode described in the utility model is preferably sodium ion, potassium ion, calcium ion type ion selectivity
Microelectrode.
Optical fiber probe described in the utility model is immunity biosensor, and the optical fiber probe surface is fixed with test substance
Corresponding antigen or antibody.The test substance is one or more of prostaglandin, leukotriene, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2.
Preferably, the optical fiber probe is selected from optical fiber nano fluorescent biosensor, optical fiber nano immune sensor, optical fiber
One or more of spr sensor.
One preferred embodiment of the utility model, the long 20~40mm of the needle body, preferably 25mm, needle tubing outer diameter is 0.3-
0.5mm, preferably 0.4mm, 150 × 600 μm of needle core area, the injection needle outer diameter is 0.25~0.35 mm, preferably
0.25mm, the ion-selective microelectrode head end diameter are 1-10 μm, and preferably 2.5 μm, institute's optical fiber probe head end diameter is 10
Nm~600 μm.
Injection needle described in the utility model can be transfused the medicines such as botulinal toxin A, steroids, arcotic to patient
Object.
Document " sodium ion can be used in the microelectrode that ion-selective microelectrode described in the utility model is well known in the art
The development and application of selective double-barelled microelectrode " (village Yunlong Chinese biomedical engineering journal, volume 1991,10, the 2nd phase),
" Primary Study that Pvc Matrix Membrane Calcium Ion-selective Microelectrode is applied in dentistry research " (river Liu Lu tooth body dental pulp Periodontics is miscellaneous
Will .1997 September the 3rd phase of volume 7) etc. structure disclosed in documents or method preparation.
Optical fiber probe described in the utility model is a kind of biological immune sensing device based on optical principle, is that will directly resist
The immune response of body antigen is changed into detectable continuous signal, eliminates the labeling process to antibody or antigen protein molecule, protects
The bioactivity of albumen is held, moving element is few, strong without electrical contact, anti-electromagnetic interference capability, by state modulator, can obtain
Very high stability.
Optical fiber probe described in the utility model can be sensed selected from optical fiber nano fluorescent biosensor, optical fiber nano immune
One or more of device, optical fiber SPR sensor.
Nano-probe is a kind of novel ultramicrobe sensor that can detect single living cell, and probe size is only nanometer amount
Grade (1-100nm).Grow rapidly the novel sensor of getting up as biosensor technique field, have it is small in size, can be
The various features such as intracellular real-time measurement, or micro-damage not damaged to cell are the unicellular most basic technologies of research.In life
The multiple fields such as object, medicine, environmental monitoring are used widely.
Optical fiber nano fluorescent biosensor can be used for detecting some protein that itself can be fluoresced or pass through mark
Note or modification make the biological substance that itself cannot be fluoresced that fluorescence occur by optical fiber capture feedback fluorescence signal, then pass through spectrum
Instrument analyzes result.(Barke. Fiber-optic nitric oxide-selective biosensors and
Nanosensors [J] Anal Chem, 1998,70 (5): 971-976.Barke. Development and
cellular appl i cations of fiber optic nitric oxide s ensors bas ed on a gold
- absorbed fluorophore [J] Anal Chem, 1998,70 (23): 4902-4908.).
Fiber imunosensor is that optics and Photonics Technology are applied to immunization, is combined using antigen and antibody specific
Property, the amount of antigen experienced or amount of antibody are converted into a kind of sensor of available optical output signal, this kind of sensor
Traditional immunity test and the advantages of optics, biosensor technique are gathered, it is made to identify that substance has very high spy
Anisotropic, sensibility and stability.And optical fiber nano immune sensor is that nanoscale is made in sensitive portion on its basis, is both retained
The plurality of advantages of optical immuno-sensors, and make it the measurement suitable for individual cells.
Optical fiber nano immune sensor combines monoclonal antibody specific on the bioprobe of sensor head, passes through
Antigen and antibody specific combines, the biochemical being able to detect in individual cells.Firstly, will be quartzy using fibre-optical drawing instrument
Optical fiber draws extremely tiny (10~100 nm), then by optical fiber head silanization, it is therefore an objective to stick site for antibody generation.
After antibody is integrated to behind optical fiber head by fiber span (except the optical fiber head for combining specific antibody) it is silver-plated to prevent
Only light leaks out (sensor technology .2002 volume 21 the 12nd of the status and development of all Li Cheng optical nanosensors
Phase).
Optical fiber connector can be coupled to the optical fiber of laser with welding the preceding paragraph, laser is transferred to the tip of nano optical fibers probe
It is contacted with test substance, to excite the spectrum of test substance, optical signalling is captured through optical fiber and collected, and feeds back to spectrometer progress
Analysis.Or optical fiber connector is coupled and connect with incident optical and the output optical fiber, form Y-shaped optical fiber, incident optical and light source
Generator connection, the output optical fiber are connect with spectrometer.(appoint the development of loud and clear nano optical fibers probe and apply Zhengzhou University).
Surface plasma body resonant vibration (Surface Plasmon Resonance, SPR) sensor is to interface medium composition
Minor change it is very sensitive, be widely used in numerous areas such as Surface testing, biomedicine, environmental monitorings.Optical fiber
SPR detection system is usually by wideband light source, Y type fiber coupler, optical fiber pickup probe, fiber spectrometer, computer
And its relevant data acquisition and processing module form.(exploitation of Feng's Li Hang optical fiber new structure spr sensor and detection application are ground
Study carefully Nanjing Aero-Space University).Carry out sensitive quick IgG detection using SPR biosensor technique, in medical diagnosis on disease or
There is potential application value in the fields such as antibody drug production process monitoring.(SPR of the Liu Qiang based on light guide capillary tube device is raw
Object sensor and IgG detect Journal of Dalian University of Technology Total .2015, Vol.55, No.4).
The utility model advantage
The utility model improves traditional myoelectricity and checks needle, and traditional myoelectricity is checked that needle is combined with injection needle, using same
After heart circle electrode needle obtains affected part electromyogram, injection needle is recycled, individualized treatment is transfused to affected part by syringe pump
Drug can be accurately positioned affected part, and treat giving immediately, improve the efficiency and effect for the treatment of.
In addition, traditional myoelectricity is checked that needle is combined with ion-selective microelectrode and/or optical fiber probe by the utility model,
The concentration variation that special ion in muscle cell is detected by ion-selective microelectrode, by by nociceptive pain medium forefront
Parathyrine, leukotriene, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 specific antibody combine fixed to optical fiber probe head end, detect prostaglandin, leukotriene, P object
The variation of the chemical substances such as matter, by the amount of antigen experienced or amount of antibody be converted into can optical output signal, and analyzed.Energy
Enough changes that lesion muscle area chemical signal is detected while carrying out electromyography help doctor to make disease in time and examine
Disconnected, the drug for effectively instructing doctor's selection to be more suitable for, which is given, treats.
Detailed description of the invention
Fig. 1 is that myoelectricity described in the utility model embodiment 1 checks needle connecting detection equipment schematic diagram.
Fig. 2 is that myoelectricity described in the utility model embodiment 1 checks needle syringe needle partial enlargement structural representation.
Fig. 3 is that myoelectricity described in the utility model embodiment 1 checks enlarged structure schematic diagram inside needle needle body.
Fig. 4 is that myoelectricity described in the utility model embodiment 2 checks needle needle body partial enlargement structural representation.
Fig. 5 is that myoelectricity described in the utility model embodiment 2 checks needle connecting detection equipment schematic diagram.
Fig. 6 is that myoelectricity described in the utility model embodiment 2 checks needle connecting detection equipment schematic diagram.
Specific embodiment
Used term in the present invention is unless otherwise indicated, generally logical with those of ordinary skill in the art
The meaning understood.
The utility model is described in further detail combined with specific embodiments below and referring to data.It should be understood that the embodiment
The utility model solely for the purpose of illustration, rather than the scope of the utility model is limited in any way.
In the examples below, the various processes and method being not described in detail are conventional methods as known in the art.Under
Material used in example, reagent, device, instrument, equipment etc. are stated, unless otherwise specified, is commercially obtained.
The present invention will be further described combined with specific embodiments below.
Embodiment 1
A kind of medicative myoelectricity inspection needle of tool, as shown in Figure 1-3, including needle body 1 and needle handle 2,1 one end of needle body is solid
It connects in 2 end of needle handle, needle body includes housing needle tubing 3, concentric circles pin electrode 4 and injection needle 5, concentric circles pin electrode and injection needle
Pipe is set in housing needle tubing, and the concentric circles pin electrode 4 includes needle tubing 6 and needle core 7, and the needle tubing 6 is reference electrode, needle core 7
For recording electrode, needle tubing inner and outer surfaces and needle core surface are equipped with insulating layer, and needle tubing and needle core are separately connected conducting wire 8 across needle
Inside handle, conducting wire is connect with electromyogram and evoked potentuial measuring system 9；5 connecting conduit 10 of injection needle passes through inside needle handle and note
Penetrate pump connection 11.
Embodiment 2
A kind of medicative myoelectricity inspection needle of tool, as shown in figures 2-6, including needle body 1 and needle handle 2,1 one end of needle body are solid
It connects in 2 end of needle handle, needle body includes housing needle tubing 3, concentric circles pin electrode 4 and injection needle 5, concentric circles pin electrode and injection needle
Pipe is set in housing needle tubing, and the concentric circles pin electrode 4 includes needle tubing 6 and needle core 7, and the needle tubing 6 is reference electrode, needle core 7
For recording electrode, needle tubing inner and outer surfaces and needle core surface are equipped with insulating layer, and needle tubing and needle core are separately connected conducting wire 8 across needle
Inside handle, conducting wire is connect with electromyogram and evoked potentuial measuring system 9；5 connecting conduit 10 of injection needle passes through inside needle handle and note
Penetrate pump connection 11.On the needle tubing inner surface insulating layer and/or needle core surface insulation layer of concentric circles pin electrode or needle tubing inner surface
Between insulating layer and needle core surface insulation layer be equipped with one or several ion-selective microelectrodes 12 and optical fiber probe 13, it is described from
Sub- selectivity micro-electrode has head end and end, and head end receives ion concentration variable signal, and end connecting wire 14 passes through needle handle
Inside is connect with potentiometer 15；The optical fiber probe has head end and end, and head end detects chemical substance signal, and end is in needle handle
Inside couples and connects with the output optical fiber 16 inside needle handle, and the output optical fiber 16 connect (Fig. 5) with spectrometer 18；Or
The optical fiber probe end couples and connects with incident optical 17 and the output optical fiber 16 inside needle handle or inside needle handle, incident
Optical fiber 17 is connect with light source generator 19, and the output optical fiber 16 connect (Fig. 6) with spectrometer 18.
Myoelectricity described in the utility model checks needle before use, by nociceptive pain medium prostaglandin, leukotriene, P object
The specific antibody of matter combines the head end for being fixed to optical fiber probe in advance.In use, needle body is inserted into patient muscle, needle tubing is made
For reference electrode, needle core collects patient muscle as recording electrode needle body and shrinks generated ultra-weak electronic signal, signal is transmitted
To electromyogram and evoked potentuial measuring system.Meanwhile using sodium ion, potassium ion, calcium in ion-selective microelectrode detection muscle cell
The concentration of ion changes, and transmits a signal to potentiometer by conducting wire.The specific antibody of fluorescent marker or modification can be used,
When in conjunction with the nociceptive pains media such as specific antibody and prostaglandin, leukotriene, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2, optical fiber captures fluorescence, and by going out
Optical fiber feedback fluorescence signal is penetrated to analyze result to spectrometer.Alternatively, characteristic antibody is integrated to optical fiber head end, optical fiber
End couples and connects with incident optical and the output optical fiber, forms Y-shaped optical fiber, and laser is transferred to nano optical fibers by incident optical
The head end of probe is contacted with test substance, to excite the spectrum of test substance, optical signalling is captured through the output optical fiber and collected, instead
Spectrometer of feeding is analyzed.Doctor by comprehensive analysis through processed electric signal, optical signal and waveform etc. come to patient into
Row diagnosis.By syringe pump connection 11, gives and treat to the suitable drug of affected part infusion through conduit 10 and injection needle 5.
Claims (10)
1. a kind of medicative myoelectricity of tool checks needle, it is characterised in that including needle body and needle handle, needle body one end is fixed in needle
Pommel portion, needle body include housing needle tubing, concentric circles pin electrode and injection needle, and concentric circles pin electrode and injection needle are set to housing
In needle tubing, the concentric circles pin electrode includes needle tubing and needle core, and the needle tubing is reference electrode, and needle core is recording electrode, needle tubing
Inner and outer surfaces and needle core surface are equipped with insulating layer, and needle tubing and needle core are separately connected conducting wire inside needle handle；The injection needle
Pipe connecting conduit, which passes through, to be connect inside needle handle with syringe pump.
2. myoelectricity as described in claim 1 checks needle, it is characterised in that the needle tubing inner surface of the concentric circles pin electrode insulate
It is equipped on layer and/or needle core surface insulation layer or between needle tubing inner surface insulating layer and needle core surface insulation layer one or several
Ion-selective microelectrode and/or optical fiber probe, the microelectrode connecting wire pass through inside needle handle；The optical fiber probe is in needle
It couples and connects with the output optical fiber inside handle or across needle handle；Or the optical fiber probe end inside needle handle or pass through needle handle with
Incident optical and the output optical fiber are coupled and are connect.
3. myoelectricity as claimed in claim 2 checks needle, it is characterised in that the ion-selective microelectrode and/or optical fiber nanometer
Probe is axially distributed along needle body.
4. myoelectricity as claimed in claim 2 checks needle, it is characterised in that the ion-selective microelectrode be sodium ion, potassium from
One or more of son, calcium ion type ion-selective microelectrode.
5. myoelectricity as claimed in claim 2 checks needle, it is characterised in that the optical fiber probe is immunity biosensor, described
Optical fiber probe surface is fixed with the corresponding antigen of test substance or antibody.
6. myoelectricity as claimed in claim 5 checks needle, it is characterised in that the test substance is prostaglandin, leukotriene, P object
One or more of matter.
7. myoelectricity as claimed in claim 2 checks needle, it is characterised in that the optical fiber probe is selected from optical fiber nano fluorescent biology
One or more of sensor, optical fiber nano immune sensor, optical fiber SPR sensor.
8. myoelectricity as described in claim 1 checks needle, it is characterised in that the long 20~40mm of the needle body, outer casing needle pipe outside diameter are
0.55~0.85mm, concentric circles pin electrode needle tubing outer diameter be 0.3~0.5mm, 150 × 600 μm of needle core area, outside injection needle
Diameter is 0.25~0.35mm.
9. myoelectricity as claimed in claim 2 checks needle, it is characterised in that it is characterized in that the needle body grows 20~40mm, housing
Needle tubing outer diameter is 0.55~0.85mm, the needle tubing outer diameter of concentric circles pin electrode is 0.3~0.5mm, 150 × 600 μm of needle core area,
Injection needle outer diameter is 0.25~0.35mm, and the ion-selective microelectrode head end diameter is 1-10 μm, institute's optical fiber probe head
End diameter is 10 nm~600 μm.
10. myoelectricity as claimed in claim 9 checks needle, it is characterised in that the needle body 25mm, outer casing needle pipe outside diameter is
0.65mm, the needle tubing outer diameter of concentric circles pin electrode are 0.4mm, 150 × 600 μm of needle core area, the ion-selective microelectrode
Head end diameter is 2.5 μm, and institute's optical fiber probe head end diameter is 10 nm~600 μm, and injection needle outer diameter is 0.25mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721150359.2U CN208447588U (en) | 2017-09-08 | 2017-09-08 | A kind of medicative myoelectricity inspection needle of tool |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201721150359.2U CN208447588U (en) | 2017-09-08 | 2017-09-08 | A kind of medicative myoelectricity inspection needle of tool |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109464146A (en) * | 2017-09-08 | 2019-03-15 | 南京医科大学第二附属医院 | A kind of medicative myoelectricity inspection needle of tool |
| CN112237656A (en) * | 2019-07-19 | 2021-01-19 | 上海移宇科技股份有限公司 | Detect artifical pancreas equipment of infusion integral type closed loop |
| WO2023060669A1 (en) * | 2021-10-12 | 2023-04-20 | 中山大学 | Marker detection device based on carbon tube/mxenes and preparation method therefor |
-
2017
- 2017-09-08 CN CN201721150359.2U patent/CN208447588U/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109464146A (en) * | 2017-09-08 | 2019-03-15 | 南京医科大学第二附属医院 | A kind of medicative myoelectricity inspection needle of tool |
| CN109464146B (en) * | 2017-09-08 | 2023-12-05 | 南京医科大学第二附属医院 | Myoelectricity inspection needle with treatment effect |
| CN112237656A (en) * | 2019-07-19 | 2021-01-19 | 上海移宇科技股份有限公司 | Detect artifical pancreas equipment of infusion integral type closed loop |
| CN112237656B (en) * | 2019-07-19 | 2023-02-17 | 上海移宇科技股份有限公司 | Detect artifical pancreas equipment of infusion integral type closed loop |
| WO2023060669A1 (en) * | 2021-10-12 | 2023-04-20 | 中山大学 | Marker detection device based on carbon tube/mxenes and preparation method therefor |
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