CN207666588U - A kind of myoelectricity inspection needle - Google Patents

A kind of myoelectricity inspection needle Download PDF

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Publication number
CN207666588U
CN207666588U CN201720542120.3U CN201720542120U CN207666588U CN 207666588 U CN207666588 U CN 207666588U CN 201720542120 U CN201720542120 U CN 201720542120U CN 207666588 U CN207666588 U CN 207666588U
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China
Prior art keywords
needle
optical fiber
ion
myoelectricity
handle
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CN201720542120.3U
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Chinese (zh)
Inventor
史兆春
李亮
万琪
秦晓旋
陈欢
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Jiangsu Province Hospital First Affiliated Hospital With Nanjing Medical University
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Jiangsu Province Hospital First Affiliated Hospital With Nanjing Medical University
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Abstract

The utility model discloses a kind of myoelectricities to check needle, including needle body and needle handle, needle body one end is fixed in needle handle end, needle body is concentric circles pin electrode, including needle tubing and needle core, needle tubing inner surface and needle core surface are equipped with insulating layer, and one or several ion-selective microelectrodes and/or optical fiber probe are equipped on needle tubing inner surface insulating layer and/or needle core surface insulation layer or between needle tubing inner surface insulating layer and needle core surface insulation layer.Traditional myoelectricity inspection needle is combined by the utility model with ion-selective microelectrode and/or optical fiber probe, and the change of lesion muscle area chemical signal can be detected while carrying out electromyography, doctor is helped to make medical diagnosis on disease in time.

Description

A kind of myoelectricity inspection needle
Technical field
The utility model belongs to medical instruments field, and in particular to a kind of myoelectricity inspection for evaluating the lesion situation of muscle Look into needle.
Background technology
Electromyogram(electromyography)(Abbreviation EMG), refer to applied electronics instrument record muscle it is static or receive Electrical activity and electrical stimulation when contracting check nerve, muscle excitement and conduction function, are that record nerves and muscles bioelectricity is lived It moves to judge a kind of electrodiagnosis method of its function.Two kinds of generally use is traced:One is surface abductions, i.e., electrode Attach the method for exporting current potential on the skin;Another kind is pin electrode method, i.e., pin electrode is pierced into muscle exports local potential Method.This method can record each action potential of muscle respectively, and according to dynamic from the muscle per second for several times to two, 30 times Make current potential situation, find the exception of frequency, evaluates the lesion situation of muscle accordingly.
Pin electrode is a kind of common medical energy converter part, and the pin electrode being clinically commonly used includes concentric round needle electricity Pole, monopolar needle electrode and single fiber pin electrode.Concentric circles pin electrode is the adapted electrode of electromyograph, is applied to electro photoluminescence inspection Whether nerve is impaired and damages property and degree, in use, pin electrode needle body is inserted into patient muscle, needle body collects patient's flesh Meat shrinks generated ultra-weak electronic signal and is then connected to terminal by conductive electrode and conducting wire, and doctor is by analysis through processing The electric signal and waveform crossed diagnoses patient.
Common pin electrode is concentric circles pin electrode, i.e., wears an eradication edge filament, needle casing pack at needle tubing center Expire insulating materials (such as epoxy resin), then file the top of needle with file, so that central wire, which is exposed, is used as contact.Internal thread is general It is made of nichrome, silver or platinum, diameter about 0.1mm.Needle point is ellipse, and area is 600 μm of 150 μ m.Filament is another The core wire of terminated coaxial cable, the needle body are connected on the shielding line of coaxial cable.This electrode has shielding action, also referred to as shields Cover pin electrode.
Current above-mentioned pin electrode can only meet routine clinical detection needs, such as four limbs and trunk compared with big muscle, and for Head And Face or other smaller muscle, patient does not tolerate inspection generally, and existing pin electrode cannot reflect lesion muscle area chemistry The change of signal.
Invention content
The utility model is in view of the shortcomings of the prior art, provide a kind of can detect the new of chemical signal and electric signal simultaneously Type myoelectricity checks needle.
The utility model specific technical solution is as follows:
A kind of myoelectricity inspection needle, including needle body and needle handle, needle body one end are fixed in needle handle end, and needle body is concentric round needle electricity Pole, including needle tubing and needle core, the needle tubing are reference electrode, and needle core is recording electrode, and the needle tubing and needle core are separately connected and lead For line through being connect with electromyogram and evoked potentuial measuring system inside needle handle, the needle tubing inner surface and needle core surface are equipped with insulating layer, needle It is set on pipe internal surface insulating layer and/or needle core surface insulation layer or between needle tubing inner surface insulating layer and needle core surface insulation layer There are one or several ion-selective microelectrodes and/or optical fiber probe, the ion-selective microelectrode there is head end and end, Head end receives ion concentration variable signal, and end connecting wire, which passes through, to be connect inside needle handle with potentiometer;The optical fiber probe tool There are head end and end, head end to detect chemical substance signal, end couples inside needle handle or inside needle handle with the output optical fiber And connect, the output optical fiber is connect with spectrometer;Or the optical fiber probe end inside needle handle or inside the needle handle with Incident optical and the output optical fiber are coupled and are connect, and incident optical is connect with light source generator, and the output optical fiber is connect with spectrometer.
Preferably, the ion-selective microelectrode and/or optical fiber nano-probe are axially distributed along needle body.
Ion-selective microelectrode described in the utility model is preferably sodium ion, potassium ion, calcium ion type ion selectivity Microelectrode.
Optical fiber probe described in the utility model is immunity biosensor, and the optical fiber probe surface is fixed with test substance Corresponding antigen or antibody.The test substance is one or more of prostaglandin, leukotriene, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2.
Preferably, the optical fiber probe is selected from optical fiber nano fluorescent biosensor, optical fiber nano immune sensor, optical fiber One or more of spr sensor.
One preferred embodiment of the utility model, the needle body grow 20~40mm, preferably 25mm, and needle tubing outer diameter is 0.3- 0.5mm, preferably 0.4mm, 150 × 600 μm of needle core area, a diameter of 1-10 μm of the ion-selective microelectrode head end, preferably 2.5 μm, a diameter of 10 nm~600 μm of institute's optical fiber probe head end.
The microelectrode that ion-selective microelectrode described in the utility model is well known in the art, can be used document《Sodium ion The development and application of selective double-barelled microelectrode》(Village Yunlong Chinese biomedical engineering journals, volume 1991,10, the 2nd phase)、 《The Primary Study that Pvc Matrix Membrane Calcium Ion-selective Microelectrode is applied in dentistry research》(The rivers Liu Lu tooth body dental pulp Periodontics is miscellaneous Will .1997 Septembers the 3rd phase of volume 7)It is prepared by structure or method disclosed in equal documents.
Optical fiber probe described in the utility model is a kind of biological immune sensing device based on optical principle, is that will directly resist Body antigen immune response is changed into detectable continuous signal, eliminates the labeling process to antibody or antigen protein molecule, protects The bioactivity of albumen is held, moving element is few, strong without electrical contact, anti-electromagnetic interference capability, by state modulator, can obtain Very high stability.
Optical fiber probe described in the utility model can be selected from optical fiber nano fluorescent biosensor, optical fiber nano immune senses One or more of device, optical fiber SPR sensor.
Nano-probe is a kind of novel ultramicrobe sensor that can detect single living cell, and probe size is only nanometer amount Grade (1-100nm).Grow rapidly the novel sensor of getting up as biosensor technique field, have it is small, can be The intracellular various features such as measurement, or micro-damage not damaged to cell in real time are the unicellular most basic technologies of research.In life The multiple fields such as object, medicine, environmental monitoring are used widely.
Optical fiber nano fluorescent biosensor can be used for detecting the protein that some itself can fluoresce or pass through mark Note or modification make the biological substance that itself cannot be fluoresced that fluorescence occur by optical fiber capture feedback fluorescence signal, then pass through spectrum Instrument analyzes result.(Barke. Fiber-optic nitric oxide -selective biosensors and Nanosensors [J] Anal Chem, 1998,70 (5):971-976.Barke. Development and cellular appl i cations of fiber optic nitric oxide s ensors bas ed on a gold - absorbed fluorophore [J] Anal Chem, 1998,70 (23): 4902-4908.).
Fiber imunosensor is that optics and Photonics Technology are applied to immunization, is combined using antigen and antibody specific Property, the amount of antigen experienced or amount of antibody are converted into a kind of sensor of available optical output signal, this kind of sensor Traditional immunity test and the advantages of optics, biosensor technique are gathered, it is made to identify that substance has very high spy Anisotropic, sensibility and stability.And optical fiber nano immune sensor is that nanoscale is made in sensitive portion on its basis, is both retained The plurality of advantages of optical immuno-sensors, and make it the measurement suitable for individual cells.
Optical fiber nano immune sensor combines monoclonal antibody specific on the bioprobe of sensor head, passes through Antigen and antibody specific combines, and can detect the biochemical in individual cells.It first, will be quartzy using fibre-optical drawing instrument Optical fiber draws extremely tiny (10~100 nm), then by optical fiber head silanization, it is therefore an objective to stick site for antibody generation. After antibody is attached to behind optical fiber head by fiber span (except the optical fiber head for combining specific antibody) it is silver-plated to prevent Only light leaks out(The present situations of all Li Cheng optical nanosensors and development sensor technologies .2002 volumes 21 the 12nd Phase).
Optical fiber connector can be coupled to the optical fiber of laser with welding the preceding paragraph, laser is transferred to the tip of nano optical fibers probe It is contacted with test substance, to excite the spectrum of test substance, optical signalling to capture and collect through optical fiber, feeds back to spectrometer progress Analysis.Or optical fiber connector is coupled and connect with incident optical and the output optical fiber, form Y-shaped optical fiber, incident optical and light source Generator connects, and the output optical fiber is connect with spectrometer.(Appoint development and the application Zhengzhou University of loud and clear nano optical fibers probe).
Surface plasma body resonant vibration (Surface Plasmon Resonance, SPR) sensor is to interface medium composition Minor change it is very sensitive, be widely used in numerous areas such as Surface testing, biomedicine, environmental monitorings.Optical fiber SPR detecting systems are usually by wideband light source, Y types fiber coupler, optical fiber pickup probe, fiber spectrometer, computer And its relevant data acquisition and processing module form.(Feng's Li Hang optical fiber new structure spr sensors are developed and detection application is ground Study carefully Nanjing Aero-Space University).Carry out sensitive quick IgG detection using SPR biosensor techniques, in medical diagnosis on disease or There is potential application value in the fields such as antibody drug production process monitoring.(SPR lifes of the Liu Qiang based on light guide capillary tube device Object sensor and IgG detection Journal of Dalian University of Technology Total .2015, Vol.55, No.4).
The utility model advantage
Traditional myoelectricity inspection needle is combined by the utility model with ion-selective microelectrode and/or optical fiber probe, is passed through Ion-selective microelectrode detects the concentration variation of special ion in muscle cell, by by nociceptive pain medium prostate Element, leukotriene, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 specific antibody combine fixed to optical fiber probe head end, detection prostaglandin, leukotriene, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2 Etc. chemical substances variation, by the amount of antigen experienced or amount of antibody be converted into can optical output signal, and analyzed.It can The change that lesion muscle area chemical signal is detected while carrying out electromyography, helps doctor to make medical diagnosis on disease in time.
In addition, the myoelectricity that clinically uses checks that needle can be used for checking the electrical signal collection compared with big muscle at present, but to compared with Small, relatively thin muscle there is no suitable myoelectricity acquisition needle, be adopted particularly with Head And Face myalgia, the electromyography signal of hypermyotonia Collection lacks effective tool, and with disease progression, patient does not tolerate existing pin electrode inspection generally.Such as it is clinically commonly used Disposable pin electrode(Specification:37mm × 0.46mm (26G)), the common adult's myoelectricity needle check of this model, disadvantage:Head pain is suffered from Person is not resistant to generally.And specification is 25mm × 0.30mm (30G))Inspection needle, be usually used in children's electromyographic signal collection, although Pain-suffered patient is tolerable;But it shorter is not easy to check deep part muscle.The myoelectricity inspection needle needle body length 20 of the utility model~ 40mm, preferably 25mm, needle tubing outer diameter are 0.3-0.5mm, preferably 0.4mm, 150 × 600 μm of needle core area, the ion selection Property a diameter of 1-10 μm of microelectrode head end, preferably 2.5 μm, a diameter of 10 nm~600 μm of institute's optical fiber probe head end can be used for head Prosopodynia patient's depth superficial muscular is detected with fascia.
Description of the drawings
Fig. 1 is that myoelectricity described in the utility model checks needle construction schematic diagram.
Fig. 2 is that myoelectricity described in the utility model checks needle needle body partial enlargement structural representation.
Fig. 3 is that myoelectricity described in the utility model checks that needle connecting detection equipment uses schematic diagram.
Specific implementation mode
Used term in the present invention is unless otherwise indicated, generally logical with those of ordinary skill in the art The meaning understood.
The utility model is described in further detail with reference to specific embodiment and with reference to data.It should be understood that the embodiment The utility model solely for the purpose of illustration, rather than the scope of the utility model is limited in any way.
In the examples below, the various processes and method not being described in detail are conventional methods as known in the art.Under Material used in example, reagent, device, instrument, equipment etc. are stated, unless otherwise specified, is commercially obtained.
The utility model is further illustrated with reference to specific embodiment.
Embodiment 1
A kind of myoelectricity inspection needle, including needle body 2 and needle handle 1, needle body one end are fixed in needle handle end, and needle body is concentric round needle Electrode, including needle tubing 3 and needle core 4, the needle tubing are reference electrode, and needle core is recording electrode, and the needle tubing and needle core connect respectively Conducting wire 11 is connect through being connect with electromyogram and evoked potentuial measuring system 7 inside needle handle, the needle tubing inner surface and needle core surface are equipped with absolutely On edge layer, needle tubing inner surface insulating layer and/or needle core surface insulation layer or needle tubing inner surface insulating layer and needle core surface insulation One or several ion-selective microelectrodes 5 and optical fiber probe 6 are equipped between layer, the ion-selective microelectrode has head end And end, head end receive ion concentration variable signal, end connecting wire 14, which passes through, to be connect inside needle handle with potentiometer 10;It is described Optical fiber probe have head end and end, head end detect chemical substance signal, end inside needle handle or inside needle handle with go out It penetrates optical fiber 12 to couple and connect, the output optical fiber 12 is connect with spectrometer 8;Or the optical fiber probe end inside needle handle or It couples and connects with incident optical 13 and the output optical fiber 12 inside needle handle, incident optical 13 is connect with light source generator 9, outgoing Optical fiber 12 is connect with spectrometer 8.
Myoelectricity described in the utility model checks needle before use, by nociceptive pain medium prostaglandin, leukotriene, P objects The specific antibody of matter combines the head end fixed to optical fiber probe in advance.In use, needle body is inserted into patient muscle, needle tubing is made For reference electrode, needle core collects patient muscle as recording electrode needle body and shrinks generated ultra-weak electronic signal, by signal transmission To electromyogram and evoked potentuial measuring system.Meanwhile using sodium ion, potassium ion, calcium in ion-selective microelectrode detection muscle cell The concentration of ion changes, and transmits a signal to potentiometer by conducting wire.Fluorescent marker or the specific antibody of modification can be used, When specific antibody is combined with nociceptive pains media such as prostaglandin, leukotriene, Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2s, optical fiber captures fluorescence, and by going out Optical fiber feedback fluorescence signal is penetrated to analyze result to spectrometer.Alternatively, characteristic antibody is attached to optical fiber head end, optical fiber End couples and connects with incident optical and the output optical fiber, forms Y-shaped optical fiber, and laser is transferred to nano optical fibers by incident optical The head end of probe is contacted with test substance, to excite the spectrum of test substance, optical signalling to capture and collect through the output optical fiber, instead Spectrometer of feeding is analyzed.Doctor by comprehensive analysis through processed electric signal, optical signal and waveform etc. come to patient into Row diagnosis.

Claims (8)

1. a kind of myoelectricity checks that needle, including needle body and needle handle, needle body one end are fixed in needle handle end, needle body is concentric round needle electricity Pole, including needle tubing and needle core, the needle tubing are reference electrode, and needle core is recording electrode, and the needle tubing and needle core are separately connected and lead Inside a string-passing pin handle, it is characterised in that the needle tubing inner surface and needle core surface are equipped with insulating layer, the insulation of needle tubing inner surface It is equipped on layer and/or needle core surface insulation layer or between needle tubing inner surface insulating layer and needle core surface insulation layer one or several Ion-selective microelectrode and/or optical fiber probe, the microelectrode connecting wire pass through inside needle handle;The optical fiber probe is in needle It couples and connects with the output optical fiber inside handle or across needle handle;Or the optical fiber probe end inside needle handle or across needle handle with Incident optical and the output optical fiber are coupled and are connect.
2. myoelectricity as described in claim 1 checks needle, it is characterised in that the ion-selective microelectrode and/or optical fiber nanometer Probe is axially distributed along needle body.
3. myoelectricity as described in claim 1 checks needle, it is characterised in that the ion-selective microelectrode be sodium ion, potassium from One or more of son, calcium ion type ion-selective microelectrode.
4. myoelectricity as described in claim 1 checks needle, it is characterised in that the optical fiber probe is immunity biosensor, described Optical fiber probe surface is fixed with the corresponding antigen of test substance or antibody.
5. myoelectricity as claimed in claim 4 checks needle, it is characterised in that the test substance is prostaglandin, leukotriene, P objects One or more of matter.
6. myoelectricity as described in claim 1 checks needle, it is characterised in that the optical fiber probe is selected from optical fiber nano fluorescent biology One or more of sensor, optical fiber nano immune sensor, optical fiber SPR sensor.
7. myoelectricity as described in claim 1 checks needle, it is characterised in that the needle body grows 20~40mm, and needle tubing outer diameter is 0.3-0.5mm, 150 × 600 μm of needle core area, a diameter of 1-10 μm of the ion-selective microelectrode head end, the optical fiber are visited A diameter of 10 nm~600 μm of needle end.
8. myoelectricity as claimed in claim 7 checks needle, it is characterised in that the needle body 25mm, needle tubing outer diameter are 0.4mm, needle core 150 × 600 μm of area, a diameter of 2.5 μm of the ion-selective microelectrode head end, the optical fiber probe head end a diameter of 10 Nm~600 μm.
CN201720542120.3U 2017-05-16 2017-05-16 A kind of myoelectricity inspection needle Expired - Fee Related CN207666588U (en)

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Granted publication date: 20180731

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