CN208443800U - A kind of universal highly sensitive charged aerosol liquid chromatograph - Google Patents
A kind of universal highly sensitive charged aerosol liquid chromatograph Download PDFInfo
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- CN208443800U CN208443800U CN201821200581.3U CN201821200581U CN208443800U CN 208443800 U CN208443800 U CN 208443800U CN 201821200581 U CN201821200581 U CN 201821200581U CN 208443800 U CN208443800 U CN 208443800U
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- liquid chromatograph
- charged aerosol
- high performance
- performance liquid
- work station
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Abstract
The utility model relates to a kind of universal highly sensitive charged aerosol liquid chromatographs, including charged aerosol detectors and high performance liquid chromatograph work station, it is characterized by: the chromatographic column end of the high performance liquid chromatograph work station is connected with the mixing arrangement with temperature controller by check valve, which is connected with the high performance liquid chromatograph work station；The mixing arrangement is connected with high-pressure pump by Y type interface, which is connected with solvent III.The utility model structure is simple, easy to implement, can be formed by optimizing the liquid flow temperature for entering atomizer and solvent, increase nebulization efficiency, to realize precision, sensitivity and the reproducibility for improving detection.
Description
Technical field
The utility model relates to liquid chromatograph production technical fields, more particularly to a kind of universal highly sensitive charged aerosol liquid
Chromatography.
Background technique
Charged aerosol detectors (charged aerosol detection, CAD) are ESA companies of the U.S. in October, 2004
Release a kind of novel HPLC detector with patented technology, sensitivity and repeatability height, independent of the letter of chemical structure
Number response consistency, dynamic monitoring range is wide, be widely used, operate intuitively it is simple, shown in each field in recent years outstanding
Ability.Charged aerosol detectors (CAD) are a kind of unique technologies, effect of the HPLC eluent through nitrogen in atomizer and mist
Change, wherein biggish drop flows out under the action of impinger through sewer pipe, lesser solute (analyte) drop is at room temperature
It is dry, form particles of solute.Meanwhile the nitrogen for carrier gas shunts the second burst of nitrogen stream to be formed and (contains by corona-type device
High pressure platinum wire electrode) positively charged nitrogen particle is formed, make particles of solute band through collision when reversely meeting with particles of solute
Upper positive electricity.In order to eliminate the background current as caused by the nitrogen with excessive positive charge, flowed into the air-flow containing particles of solute
Before electrostatic detection meter, the biggish particle of mobility is made (i.e. by a kind of device (having low negative voltage) for being referred to as ion trap
The lesser nitrogen particle of granularity) charging neutrality, and the small charged particle of mobility gives a particle their electric charge transfer
Collector finally measures the signal code of ionic sample with a highly sensitive electrostatic detection.Resulting signal electricity
It flows directly proportional to the content of solute (analysis substance).Charged aerosol liquid chromatograph is by chromatographic isolation part and charged aerosol detectors
Link together the system of composition.
Charged aerosol detectors have obtained in pharmacy, food, the consumer goods, industrial chemicals, the fields such as life science
It is widely applied, can be applied to any non-volatile or semi-volatile compounds, including medical compounds, lipid, carbon
Hydrate, polypeptide etc..Compared with ELSD, the dynamic range of CAD is wider, and precision is higher.
But with the increase of salinity in the liquid flow for entering detector, nebulization efficiency is deteriorated, detection sensitivity and reproducibility
It is deteriorated；Simultaneously during gradient separations, the variation with flowing phase composition can also make peak type symmetry be deteriorated, testing result
Accuracy decline.
Utility model content
The technical problem to be solved by the utility model is to provide it is a kind of raising detection accuracy and nebulization efficiency it is universal
Highly sensitive charged aerosol liquid chromatograph.
To solve the above problems, the universal highly sensitive charged aerosol liquid chromatograph of one kind described in the utility model, including
Charged aerosol detectors and high performance liquid chromatograph, it is characterised in that: work including charged aerosol detectors and high performance liquid chromatograph
It stands, it is characterised in that: the chromatographic column end of the high performance liquid chromatograph work station is connected with mixed with temperature controller by check valve
It attaches together and sets, which is connected with the high performance liquid chromatograph work station；The mixing arrangement is connected with high pressure by Y type interface
Pump, the high-pressure pump are connected with solvent III.
Compared with the prior art, the utility model has the following advantages:
1, due to being equipped with the mixing arrangement with heater and solvent III in the utility model, temperature control is equipped in mixing arrangement
Device, therefore, the utility model can be formed by optimizing the liquid flow temperature for entering atomizer and solvent, increase nebulization efficiency, from
And realize precision, sensitivity and the reproducibility for improving detection.
2, the utility model structure is simple, easy to implement.
Detailed description of the invention
Specific embodiment of the present utility model is described in further detail with reference to the accompanying drawing.
Fig. 1 is the structural schematic diagram of the utility model.
In figure: 1-charged aerosol detectors；21-chromatographic columns；22-solvents I；23-solvents II；24-mixing pumps；25—
Sample；26-waste fluid containers；27-six-way valves；3-check valves；4-mixing arrangements；5-high-pressure pumps；6-solvents III.
Specific embodiment
As shown in Figure 1, a kind of universal highly sensitive charged aerosol liquid chromatograph, including charged aerosol detectors 1 and efficient liquid
Chromatography work station.21 end of chromatographic column of high performance liquid chromatograph work station is connected with mixed with temperature controller by check valve 3
It attaches together and sets 4, which is connected with high performance liquid chromatograph work station；Mixing arrangement 4 is connected with high-pressure pump 5 by Y type interface, should
High-pressure pump 5 is connected with solvent III 6.
When work, solvent I 22 and solvent II 23 enter high performance liquid chromatography by six-way valve 27 after the mixing of mixing pump 24
Instrument work station；Sample 25 injects injection annulus by six-way valve 27；Vavle switching carries sample in injection annulus and enters chromatographic column 21, realizes
The separation of component；Solvent and excess sample 25 flow into waste fluid container 26；Eluant, eluent is by check valve 3, the back-pressure that can be prevented
Disturbance to elution solution chromatographic band, eluant, eluent are mixed with solvent III 6 into mixing arrangement 4, trip temperature of going forward side by side compensation, optimization
Eluent system afterwards enters charged aerosol detectors 1.Due to improving temperature, mobile phase solvent composition is optimized, to make to be atomized
Efficiency improves, and the electric signal detected significantly increases, and realizes efficient and sensible detection.
Claims (1)
1. a kind of universal highly sensitive charged aerosol liquid chromatograph, including charged aerosol detectors (1) and high performance liquid chromatograph work
It stands, it is characterised in that: chromatographic column (21) end of the high performance liquid chromatograph work station is connected with band temperature by check valve (3)
The mixing arrangement (4) of device is controlled, which is connected with the high performance liquid chromatograph work station；The mixing arrangement (4) passes through Y
Type interface is connected with high-pressure pump (5), which is connected with solvent III (6).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821200581.3U CN208443800U (en) | 2018-07-27 | 2018-07-27 | A kind of universal highly sensitive charged aerosol liquid chromatograph |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201821200581.3U CN208443800U (en) | 2018-07-27 | 2018-07-27 | A kind of universal highly sensitive charged aerosol liquid chromatograph |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208443800U true CN208443800U (en) | 2019-01-29 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201821200581.3U Expired - Fee Related CN208443800U (en) | 2018-07-27 | 2018-07-27 | A kind of universal highly sensitive charged aerosol liquid chromatograph |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN208443800U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024036702A1 (en) * | 2022-08-17 | 2024-02-22 | 广东精观生物医药科技有限公司 | Method for detecting aminolevulinic acid hexyl ester hydrochloride |
-
2018
- 2018-07-27 CN CN201821200581.3U patent/CN208443800U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024036702A1 (en) * | 2022-08-17 | 2024-02-22 | 广东精观生物医药科技有限公司 | Method for detecting aminolevulinic acid hexyl ester hydrochloride |
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| Date | Code | Title | Description |
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20190129 Termination date: 20210727 |