CN208405759U - The liquid feed device of human insulin injection - Google Patents

Abstract

A kind of liquid feed device of human insulin injection, has a carrier, framework has reservoir chamber and water conservancy diversion actuating unit on carrier, and installs sensor and driving chip.Water conservancy diversion actuating unit has a liquid-conveying ducts, is connected to the liquid storage outlet and drain outlet of reservoir chamber.Sensor contradicts human skin to monitor the monitoring numerical value of blood-sugar content in sweat.Driving chip receives monitoring numerical value interpretation from sensor, controls the actuating of water conservancy diversion actuating unit accordingly, and controls the switch state of the threshold switch of liquid storage outlet and drain outlet.Water conservancy diversion actuating unit generates barometric gradient after being driven, and exports the insulin fluid in reservoir chamber to drain via liquid-conveying ducts and exports, and flows into the microneedle patch being attached at below water conservancy diversion actuating unit, and through in its multiple empty micropin injection subcutaneous tissue.

Description

The liquid feed device of human insulin injection

[technical field]

This case is about a kind of liquid feed device, espespecially a kind of liquid feed device applied to human insulin injection.

[background technique]

Currently, predominantly supplementing hypoglycemic medicine, administration for the therapeutic modality of the first patients with type Ⅰ DM and the second patients with type Ⅰ DM Mode includes oral, syringe injection and insulin pump injection.It wherein takes orally and syringe injection system, patient needs daily It is voluntarily horizontal using blood glucose meter blood sampling detection own blood glucose, it takes medicine further according to blood glucose level.And insulin pump systems are by remaining needle It is formed with insulin pump, remaining needle, which is placed in, is fixed on body surface in vivo, for blood sampling and drug injection；The pancreas islet being connected with remaining needle Element pump then controls release hypoglycemic medicine according to blood glucose level.

Insulin can only use injection system due to cannot directly take orally.The remaining needle of syringe injection and insulin pump, It not only will cause patient pain in injection, and all can leave pin hole in body surface.Especially syringe injection generally required more than one day It is secondary, it will cause subcutaneous tissue because frequently injecting and generate lump.Insulin pump reduces frequency injection to the use of remaining needle, but Whole dress causes have certain volume weight, and inconvenience is carried, be arranged in will affect the daily life and movement of patient.

For above-mentioned missing, a kind of confession of safe, easy to carry, painless intelligent human insulin injection is developed in this case Liquid device provides patient and injects human insulin in daily life to control blood glucose level at any time, and solves above-mentioned tradition note The problem of penetrating mode.

[utility model content]

The main purpose of this case is to provide a kind of liquid feed device of human insulin injection, in order to solve traditional insulin Injection system will cause the problem of patient pain carries with inconvenience provide it is a kind of safe, easy to carry, painless intelligent The liquid feed device of human insulin injection, allows patient to inject human insulin in daily life to control blood glucose current potential at any time, And it is used as the artificial pancreas for being automatically replenished human insulin.

In order to achieve the above object, a broader pattern of implementing of this case is to provide a kind of feed flow dress of human insulin injection It sets, includes: a carrier；One reservoir chamber, framework for storing an insulin fluid, and have liquid storage outlet on the carrier； One water conservancy diversion actuating unit, framework have a liquid-conveying ducts on the carrier, are connected to the liquid storage outlet of the reservoir chamber, and even Logical drain outlet, transmits the insulin fluid by the drain and exports output after driving the water conservancy diversion actuating unit；Multiple valves are opened It closes, respectively one threshold switch of setting is closed for liquid storage outlet and drain outlet, control switch state；One microneedle patch, is attached at Below the water conservancy diversion actuating unit, to close and be connected to drain outlet, so that drain outlet is exported insulin fluid importing should Microneedle patch wherein, and the microneedle patch have multiple empty micropins, for minimally invasive insertion human skin export, by the insulin liquor Body injects in subcutaneous tissue；One sensor, framework is set on the carrier, to contradict on human skin, to monitor blood in sweat Sugared content, and generate a monitoring numerical value；And a driving chip, it is set on the carrier with framework, to control water conservancy diversion cause The actuating of moving cell, the switch state of the multiple threshold switch of control and the monitoring numerical value interpretation for receiving the sensor；Whereby, The microneedle patch is on multiple empty micropin minimally invasive insertion human skin, and the sensor monitors that human skin flows out sweat In a particular glucose content the monitoring numerical value when, by the driving chip control the water conservancy diversion actuating unit actuating, control simultaneously The threshold switch of liquid storage outlet is opened, the threshold switch of drain outlet is opened, with the pancreas islet for allowing the reservoir chamber to store Plain liquid is exported by the drain and is exported, and is imported in the microneedle patch, is injected by the export of multiple empty micropin by the insulin liquor Body is flowed into subcutaneous tissue.

[Detailed description of the invention]

Fig. 1 is the structural schematic diagram of the liquid feed device of human insulin injection in a preferred embodiment of this case.

Fig. 2A and Fig. 2 B is the illustrative view of threshold switch in a preferred embodiment of this case.

Fig. 3 is the application schematic diagram of the liquid feed device of human insulin injection in a preferred embodiment of this case.

Fig. 4 is the element electrical connection relationship of the liquid feed device of human insulin injection in a preferred embodiment of this case Block schematic diagram.

Fig. 5 A and Fig. 5 B are the illustrative view of the liquid feed device of human insulin injection in a preferred embodiment of this case.

Fig. 6 is the structural schematic diagram of a preferred embodiment middle valve plate layer of this case.

[specific embodiment]

The some exemplary embodiments for embodying this case features and advantages will describe in detail in the explanation of back segment.It should be understood that This case can have various variations in different aspects, all not depart from the range of this case, and explanation therein and diagram It is inherently illustrated as being used, and nand architecture is in limitation this case.

The 1st figure is please referred to, the structure for the liquid feed device of human insulin injection in a preferred embodiment of this case is shown It is intended to.Liquid feed device 100 includes carrier 1 and framework in the reservoir chamber 2 thereon of carrier 1, water conservancy diversion actuating unit 3, threshold switch 4a and 4b, microneedle patch 5, sensor 6 and driving chip 7.Carrier 1 can be but not be limited to silicon chip or PCB circuit board, and pass Sensor 6 and driving chip 7 can adopt micro electronmechanical processing procedure (MEMS) and be integrated on carrier 1.A recessed reservoir chamber 2 on carrier 1 again, To store human insulin liquid 200, and there is liquid storage outlet 21, and reservoir chamber 2 is recessed on the carrier 1 and with a lid Plate 11 is sealed.

The water conservancy diversion actuating unit 3 of the present embodiment includes a liquid-conveying ducts 31 and an actuator 32.The structure of liquid-conveying ducts 3 It takes shape in inside carrier 1, and there is an access road 311, a pressure chamber 313, an exit passageway 312 and drain outlet 314.Liquid-conveying ducts 31 are the fluid passage for being connected to liquid storage outlet 21 with drain outlet 314.More specifically, it is penetrated through on carrier 1 An access road 311 spaced apart from each other and an exit passageway 312 are set, and a recessed pressure chamber 313 is respectively communicated with entrance and leads to The one end in road 311 and exit passageway 312, and 313 top of pressure chamber is by 32 lidstock of actuator.Access road 311 is connected to The other end of pressure chamber 313 is covered with a cover closing member 12, and the liquid storage of other end connection reservoir chamber 2 is made to export 21 shapes At the fluid channel of a sealing, and it is that drain goes out that the other end of the connection of exit passageway 312 pressure chamber 313, which is formed by opening, Mouth 314.The liquid-conveying ducts 31 of water conservancy diversion actuating unit 3 be by above-mentioned access road 311, pressure chamber 313, exit passageway 312 with And sequentially series winding communicates constituted fluid passage for drain outlet 314.

The actuator 32 of the present embodiment is made of a load-bearing part 321 and an actuating element 322, and load-bearing part 321 can for one Flexible plate material covers pressure chamber 313 and is fixed on carrier 1.Actuating element 322 is a plate-shaped piezoelectric element, is attached at and holds The upper surface of holder 321.Actuating element 322 generates deformation when being applied by voltage, interlock load-bearing part 321 and generate deformation and resonate, And then the volume of amplification or compression pressure chamber 313, it forms a barometric gradient and drives insulin fluid stored by reservoir chamber 2 200 importings are flowed in access road 311 and exit passageway 312.

Threshold switch 4a, 4b of the present embodiment, which are respectively set, to be closed in liquid storage outlet 21 and drain outlet 314, by driving core Piece 7 controls its switch state, please refers to 2A figure and Fig. 2 B, is the actuation signal of threshold switch in a preferred embodiment of this case Figure.When driving chip 7, which controls water conservancy diversion actuating unit 3, to be started, threshold switch 4a, 4b are also opened；It is caused when driving chip 7 controls water conservancy diversion When moving cell 3 stops actuation, threshold switch 4a, 4b are then closed.Threshold switch 4a is identical structure with threshold switch 4b, to avoid identical knot Structure repeated explanation is only illustrated by taking threshold switch 4a as an example below.Threshold switch 4a include a sealing element 41, a holder 42 and One displacement piece 43.Multiple through-holes 411 and 421 are respectively provided on sealing element 41 and holder 42, displacement piece 43 is set to sealing element It is formed by accommodating space between 41 and holder 42, also there are multiple through-holes 431.The through-hole 431 of displacement piece 43 is substantially right Standard forms dislocation with the through-hole of sealing element 41 411 and is misaligned in the through-hole 421 of holder 42.

In the first state sample implementation of the threshold switch 4a of the present embodiment, displacement piece 43 can be an electrically charged material, and protect Gripping member 41 can be a dipolar conductive material.In the second state sample implementation of the threshold switch 4a of the present embodiment, displacement piece 43 can For a magnetic material, and holder 41 can the polar magnetic material of controlled conversion for one.As shown in Figure 2 A, when driving core Piece 7 controls holder 42 and maintains polarity identical with displacement piece 43, and displacement piece 43 is close towards sealing element 41, constitutes threshold switch 4a's It closes.As shown in Figure 2 B, the polarity different from displacement piece 43 is maintained when driving chip 7 controls holder 41, displacement piece 43 is towards guarantor Gripping member 41 is close, constitutes the unlatching of threshold switch 4a.

The microneedle patch 5 of the present embodiment has multiple empty micropins 51 and Chip Area 52, and Chip Area 52 is that tool is sticking Thin slice, microneedle patch 5 can be attached at cover closing member 12 on carrier 1 using the viscosity of Chip Area 52, and make entire microneedle patch 5 fixed In on carrier 1 there is drain to export 314 sides, and make 314 connection empty micropins 51 of drain outlet, it also can be another using Chip Area 52 Viscosity on one side and attach and be fixed on the skin of user, allow entire liquid feed device 100 be positioned on the skin of user and It does not fall.Empty micropin 51 is the micron order size fine needle that can pierce through skin, material can for high molecular polymer, metal or Silicon, preferably for the silica of tool high-biocompatibility.The pore size of empty micropin 51 passes through for insulin molecule, compared with Good person, the internal diameter of empty micropin 51 is between 10 microns (μm) to 550 microns (μm), and the length of empty micropin 51 is between 400 microns (μm) can be inserted into the subcutaneous tissue of human body and be pierced into depth and do not touch human nerve to 900 microns (μm), therefore will not make completely At pain.Multiple empty micropins 51 are set to adopt in microneedle patch 5 and be arranged with array manner, each empty micropin 51 it is adjacent it Spacing is greater than 200 microns (μm), to guarantee that each empty micropin 51 can smoothly be pierced into skin.And such array manner setting is multiple Empty micropin 51, wherein an empty micropin 51 does not block and influences insulin injection reason, because other empty micropins 51 can be after Infusing insulin is held in continuation of insurance.

Referring to Fig. 3, its application signal for the liquid feed device of human insulin injection in a preferred embodiment of this case Figure.As shown, since liquid feed device 100 is lamellar and has miniature sizes, it is viscous in combination with the Chip Area 52 of microneedle patch 5 Property is fixedly attached on human skin.In this way, liquid feed device 100 can be made to be fixed on human body using only the viscosity of Chip Area 52 Any position.

Please refer to the feed flow dress that Fig. 1 and the 4th figure, Fig. 4 are human insulin injection in a preferred embodiment of this case The block schematic diagram for the element electrical connection relationship set.Sensor 6 is set on carrier 1 with micro electronmechanical processing procedure, works as liquid feed device 100 when setting on the skin for be positioned at user, and sensor 6 can contradict human skin and monitor glucose content in human sweat, The blood glucose current potential of human body is estimated according to this, and generates corresponding blood sugar monitoring numerical value.Driving chip 7 is set to micro electronmechanical processing procedure On carrier 1, it is respectively coupled to the actuator 31, threshold switch 4a and 4b and sensor 6 of water conservancy diversion actuating unit 3, so as to transmitting signal 31 actuation of actuator of water conservancy diversion actuating unit 3 is controlled, and controls the switch state of threshold switch 4a and 4b, and is received from sensing The monitoring numerical value interpretation of device 6.In an embodiment of this case, driving chip 7 further includes a graphene battery to provide power supply.

5A figure and Fig. 5 B are please referred to, is the liquid feed device of human insulin injection in a preferred embodiment of this case Illustrative view.When sensor 6 senses a particular glucose content monitoring numerical value, driving chip 7 transmits an enabling signal extremely Water conservancy diversion actuating unit 3 to start actuator 32, while controlling that threshold switch 4a and 4b are in open state, and actuating element 322 is by voltage Apply and inverse piezoelectric effect occurs and generates deformation, and then interlocks load-bearing part 321 and generate resonance.At this point, actuator 32 is vertical along one Direction carries out reciprocating.As shown in Figure 5A, when actuator 32 vibrates upwards, pressure chamber 313 is expanded and volume increases Add, and then generate a suction, insulin fluid 200 is driven to import in pressure chamber 313 from 21 outflow of liquid storage outlet.Then, As shown in Figure 5 B, when 32 downward deformation of actuator, the volume of meeting compression pressure chamber 313 makes insulin fluid 200 therein It is squeezed and flows downward and push to exit passageway 312 and flow to drain outlet 314, then import the multiple hollow of microneedle patch 5 In micropin 51, and then completes a certain amount of insulin fluid 200 and inject in subcutis.Certainly, pancreas is if desired reinjected Island element liquid 200 completes the amount of demand, above-mentioned about 32 actuation of actuator of repetitive cycling, that is, sustainable by insulin fluid 200 from Liquid storage outlet 21 is delivered to drain outlet 314 via liquid-conveying ducts 31 and injects in subcutis through empty micropin 51, can It is used as the artificial pancreas for being automatically replenished human insulin.

The liquid feed device 100 of this case supplies liquid countercurrent in order to prevent, as shown in Figure 1, can further entering on the carrier 1 A valve block layer 300 is further set in mouth channel 311, exit passageway 312.It is this case please refer to Fig. 1 and Fig. 6, Fig. 6 The structural schematic diagram of one preferred embodiment middle valve plate layer.More specifically, carrier 1 is in access road 311 and exit passageway 312 One middle section position is respectively equipped with chamber 13, and a valve block layer 300 capping access road 311 and exit passageway are embedded on carrier 1 312.As shown in fig. 6, valve block layer 300 is made of a flexible plate material, and respectively it is corresponding cover access road 311 and Valve block 33a, 33b are formed at exit passageway 312, define a central portion 331a on valve block 33a, and give with multiple interconnecting piece 332a It is supported on valve block layer 300 with connection, and multiple interconnecting piece 332a are separated out multiple gap 333a for liquid communication.Described Central portion 331a, interconnecting piece 332a and gap 333a constitute valve block 33a.Similarly, the central portion 331b on valve block layer 300, Interconnecting piece 332b and gap 333b also constitutes mutually isostructural valve block 33b.

In addition, please referring to as shown in Fig. 1, carrier 1 further has respectively at access road 311, exit passageway 312 There is protrusion structure 14a, 14b, protrusion structure 14a is set at access road 311, and is arranged in the bottom chamber 13a；And protrusion Structure 14b is set at exit passageway 312, and is arranged at the top of chamber 13b.Protrusion structure 14a, 14b can make above-mentioned valve block Central portion 331a, 331b of 33a, 33b support contact and generate a prestressing and contact effect.By above-mentioned setting, in actuator 31 When non-actuation, valve block 33a can close isolation access road 311, and valve block 33b then closes isolation exit passageway 312；Such one Come, can prevent the insulin fluid 200 in access road 311 and exit passageway 312 from adverse current occurs.

In more detail, when actuator 31 vibrates upwards during actuation, pressure chamber 313 expands and volume increases Add, so generate a suction, drive the valve block 33a of access road 311 be under pressure chamber 313 pressure difference variation and inhaled upwards It is attached.At this point, the central portion 331a of valve block 33a is rapidly separated the state for contradicting protrusion structure 14a, access road 311 thus unlatching, Insulin fluid 200 can import chamber 13a via multiple gap 333a and be circulated in pressure chamber 313 in such channel.When When actuator 32 vibrates downwards, the volume of meeting compression pressure chamber 313, and then a thrust is generated, drive the valve of exit passageway 312 Piece 33b is made the central portion 331b of valve block 33b be rapidly separated the state for contradicting protrusion structure 14b, exit passageway by the thrust 312 thus open, and insulin fluid 200 can import chamber 13b via multiple gap 333b and be circulated to outlet in such channel It is directed into drain outlet 314 in channel 312, then imports in multiple empty micropins 51 of microneedle patch 5, and then completes a certain amount of Insulin fluid 200 injects in subcutis.Simultaneously, the valve block 33a of access road 311 is under pressure chamber 313 Compression volume variation generates thrust, and then the central portion 331a of valve block 33a is made to reply the prestressing effect for contradicting protrusion structure 14a, Access road 311 is closed, insulin fluid 200 will not generate adverse current from access road 311 in channel.

This case is a kind of liquid feed device 100 of safe, easy to carry, painless intelligent human insulin injection, is provided Patient injects human insulin in daily life to control the device of blood glucose current potential at any time, though it is miniaturized devices, storage The units that sap cavity room 2 stores human insulin liquid 200 can be limited, and also be can pass through the external importing reservoir chamber 2 of pipeline, allowed In the reservoir injection reservoir chamber 2 of one insulin that can be supplemented with oneself, to constitute in a manner of continuous liquid supply.

In conclusion can drive and lead when the liquid feed device 100 of this case monitors that the blood glucose of patient is excessively high through sensor 6 The actuator 32 for flowing actuating unit 3 changes the volume of pressure chamber 313, and generating barometric gradient makes insulin fluid 200 from liquid storage Chamber 2 flows out, and flows through the microneedle patch 5 of the output of liquid-conveying ducts 31 to 3 lower section of water conservancy diversion actuating unit, then through microneedle patch 5 Multiple empty micropins 51 automatically inject human insulin liquid 200 to the subcutaneous tissue of patient, can be used as and be automatically replenished human body pancreas The artificial pancreas of island element uses.Also, through the setting of threshold switch 4a, 4b, the injection volume for being precisely controlled insulin fluid 200 is anti- Non-return stream, compared to traditional insulin injections, the advantage with painless, easy to carry and automatic detection injection opportunity, Great industry utilizes, and whence proposes patent application.

This case appointed as person familiar with the technology apply craftsman think and be it is all as modify, it is so neither de- such as attached claim Be intended to Protector.

[symbol description]

100: the liquid feed device of human insulin injection

200: insulin fluid

300: valve block layer

1: carrier

11,12: cover closing member

13a, 13b: chamber

14a, 14b: protrusion structure

2: reservoir chamber

21: liquid storage outlet

3: water conservancy diversion actuating unit

31: liquid-conveying ducts

311: access road

312: exit passageway

313: pressure chamber

314: drain outlet

32: actuator

321: load-bearing part

322: actuated piece

33a, 33b: valve block

331a, 331b: central portion

332a, 332b: interconnecting piece

333a, 333b: gap

4a, 4b: threshold switch

41: holder

411: through-hole

42: sealing element

421: through-hole

43: displacement piece

431: through-hole

5: microneedle patch

51: empty micropin

52: Chip Area

6: sensor

7: driving chip

Claims (15)

1. a kind of liquid feed device of human insulin injection, characterized by comprising:

One carrier；

One reservoir chamber, framework for storing an insulin fluid, and have liquid storage outlet on the carrier；

One water conservancy diversion actuating unit, framework have a liquid-conveying ducts on the carrier, are connected to the liquid storage outlet of the reservoir chamber, And it is connected to drain outlet, the insulin fluid is transmitted after driving the water conservancy diversion actuating unit by the drain exports output；

A threshold switch is respectively arranged in multiple threshold switch, liquid storage outlet and drain outlet；

One microneedle patch is attached at below the water conservancy diversion actuating unit, and is connected to drain outlet, and drain outlet is made to export the pancreas Island element liquid imports in the microneedle patch, which has multiple empty micropins, should for the export of minimally invasive insertion human skin Insulin fluid injects in subcutaneous tissue；

One sensor, framework is set on the carrier, to contradict on human skin, to monitor blood-sugar content in sweat, and is generated One monitoring numerical value；And

One driving chip is set on the carrier with framework, and to control the actuating of the water conservancy diversion actuating unit, the multiple valve of control is opened The switch state of pass and the monitoring numerical value interpretation for receiving the sensor；

Whereby, the microneedle patch is on multiple empty micropin minimally invasive insertion human skin, and the sensor monitors human body skin When skin flows out the monitoring numerical value of the particular glucose content in sweat, which is controlled by the driving chip and is caused It is dynamic, while the threshold switch for controlling liquid storage outlet is opened, the threshold switch of drain outlet is opened, to allow the reservoir chamber to store up The insulin fluid deposited is exported by the drain and is exported, and is imported in the microneedle patch, should by the export injection of multiple empty micropin Insulin fluid is in subcutaneous tissue.

2. the liquid feed device of human insulin injection as described in claim 1, which is characterized in that the water conservancy diversion actuating unit is somebody's turn to do Liquid-conveying ducts are arranged in the carrier inside, and include that an access road, a pressure chamber, an exit passageway and the drain export, The liquid storage of the inlet passage reservoir chamber exports, which is connected to drain outlet, and the access road And the exit passageway is spaced from each other, and is connected to through the pressure chamber, and the water conservancy diversion actuating unit and it is provided with an actuator, it should Actuator covers the pressure chamber, compresses pressure chamber's volume with driving and is formed in the access road and exit passageway feeding The insulin fluid is squeezed flowing.

3. the liquid feed device of human insulin injection as claimed in claim 2, which is characterized in that the actuator includes to hold Holder and an actuating element, the load-bearing part cover the pressure chamber, and attach the actuating element on a surface, and actuating member Part generate deformation and interlock the load-bearing part generate deformation resonance, with compress pressure chamber's volume be formed in the access road and should Exit passageway supplies the insulin fluid and is squeezed flowing.

4. the liquid feed device of human insulin injection as claimed in claim 3, which is characterized in that the actuating element is a piezoelectricity Element.

5. the liquid feed device of human insulin injection as claimed in claim 2, which is characterized in that the access road, the outlet One valve block and a protrusion structure are further set in channel, generate a pre- force-closed work so that the valve block contacts the protrusion structure With to control the switch state of the access road, the exit passageway, so as to preventing insulin fluid adverse current.

6. the liquid feed device of human insulin injection as described in claim 1, which is characterized in that the driving chip includes one Graphene battery, to provide power supply.

7. the liquid feed device of human insulin injection as described in claim 1, which is characterized in that each in multiple threshold switch Person includes a holder, a sealing element and a displacement piece, and wherein the displacement piece is set between the holder and the sealing element, with And multiple through-holes are respectively provided in the holder, the sealing element and the displacement piece, and it is multiple logical in the holder and the displacement piece Hole location, which is set to, to be mutually aligned, and the sealing element forms dislocation with multiple lead to the hole site of the holder and is misaligned.

8. the liquid feed device of human insulin injection as claimed in claim 7, which is characterized in that the displacement piece is one electrically charged Material, and the holder is a dipolar conductive material, to enable the displacement piece and the holder maintain opposed polarity, and court The holder is close, constitutes the unlatching of the threshold switch.

9. the liquid feed device of human insulin injection as claimed in claim 7, which is characterized in that the displacement piece is one electrically charged Material, and the holder is a dipolar conductive material, to enable the displacement piece and the holder maintain identical polar, and court The sealing element is close, constitutes the closing of the threshold switch.

10. the liquid feed device of human insulin injection as claimed in claim 7, which is characterized in that the displacement piece is a band magnetic Property material, and the holder be one can the polar magnetic material of controlled conversion, to enable the displacement piece and the holder maintain not Same polarity, and it is close towards the holder, constitute the unlatching of the threshold switch.

11. the liquid feed device of human insulin injection as claimed in claim 7, which is characterized in that the displacement piece is a band magnetic Property material, and the holder be one can the polar magnetic material of controlled conversion, with enable the displacement piece and the holder maintenance phase Same polarity, and it is close towards the sealing element, constitute the closing of the threshold switch.

12. claim 8 to 11 it is any as described in human insulin inject liquid feed device, which is characterized in that the holding Part controls its polarity by the driving chip.

13. the liquid feed device of human insulin as described in claim 1 injection, which is characterized in that the microneedle patch it is multiple Have internal diameter between 10 microns to 550 microns in empty micropin each, length is between 400 microns to 900 microns.

14. the liquid feed device of human insulin as described in claim 1 injection, which is characterized in that multiple empty micropin with Array manner arrangement, and spacing adjacent in multiple empty micropin each is greater than 200 microns.

15. the liquid feed device of human insulin as described in claim 1 injection, which is characterized in that multiple empty micropin with Earth silicon material is made.