CN208404957U - Fixator for continuous acquisition cerebrospinal fluid of rats under narcosis - Google Patents
Fixator for continuous acquisition cerebrospinal fluid of rats under narcosis Download PDFInfo
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- CN208404957U CN208404957U CN201721027484.4U CN201721027484U CN208404957U CN 208404957 U CN208404957 U CN 208404957U CN 201721027484 U CN201721027484 U CN 201721027484U CN 208404957 U CN208404957 U CN 208404957U
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- anesthesia chamber
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Abstract
The utility model discloses a kind of fixator for continuous acquisition cerebrospinal fluid of rats under narcosis, including fixed station, conduit, anesthesia chamber and adjusting bracket；Wherein, conduit is connect with anesthesia chamber, and anesthetic gases enter anesthesia chamber through conduit；The top edge for anaesthetizing chamber open end is longer than lower edge, and open end is in arc-shaped；Anesthesia chamber is connected by an elastic device with fixed station, realizes that anesthesia chamber open end presses down on by the elastic device；Adjusting bracket is opposite with anesthesia chamber open end, is installed on fixed station；Adjusting bracket includes a height adjustment axis and two width adjusting axis, and one end of two width adjusting axis is mobilizable to be installed on fixed station, and two width adjusting axis can be moved horizontally relative to height adjustment axis；Height adjustment axis can be moved up and down relative to width adjusting axis in vertical direction.The fixator of the utility model can effectively fix animal head, keep the collection point being repeated several times when sampling more accurate, avoid sampling failure caused by because of head shakiness.
Description
Technical field
The utility model relates to a kind of device for fixing experimental animal, more particularly to one kind for continuously adopting under narcosis
Collect the fixator of cerebrospinal fluid of rats.
Background technique
Cerebrospinal fluid also known as celiolymph are filled in the saturating of the cavum subarachnoidale in brain between skull and cerebral cortex
Phaneroplasm liquid, accurately for be between arachnoid and pia mater positioned at meninx.It is a kind of containing the pure of micro- glial cell
Physiological saline is mainly used as buffering corticocerebral mechanicalness.If lesion occurs for central nervous system, the detection of cerebrospinal fluid at
For important one of supplementary means.Currently, cerebrospinal fluid acquisition experiment is more and more, Baoding is very difficult when acquisition, and collection point is not
Precisely, it is easy pollution, leads to sampling failure and sampling waste.
Chinese patent CN104665951A discloses a kind of fixation device for assisting cerebrospinal fluid of rats to acquire, comprising:
Fixed plate, platen and adjustable bottom；One end of fixed plate is connected and fixed with adjustable bottom, and the other end passes through interconnecting piece and platform
Plate is connected and fixed；Adjustable bottom is equipped with several blocks parallel to each other, and one end of platen is connected by interconnecting piece and fixed plate
Fixation is connect, another end-rack adjusts platen and fixation on the block of different location on the block of adjustable bottom, through frame
The distance and angle of plate；The hose for being connected with anesthetic gases is fixed on platen；Fixed plate is equipped with the rubber for fixing rat
Muscle.The program fixes neck, chest and the waist of rat, the effective Baoding animal of energy, anti-stop by three rubber bands respectively
Object glides.
But the auxiliary device of this rat acquisition cerebrospinal fluid, on the one hand lacks and fixes to the head of rat, will lead to head
Shakiness causes sampling to fail, is on the other hand fixed with rubber band around back part of animal, and meeting pressing spine causes after puncture
Cerebrospinal fluid overflows；Both of which is unfavorable for rat and acquisition test of cerebrospinal fluid is repeated several times in narcosis, easily causes sampling
Failure and cerebrospinal fluid loss.
Document (" Chinese Professional medicine ", 2011,38 (2): 117-119) reports one kind and quickly, conveniently and without blood stains contaminates
SD cerebrospinal fluid of rats acquisition technique.Method takes male SD rat 30, is randomly divided into 3 groups, every group 10, is respectively adopted percutaneous
It punctures and scratches endorchis extraction cerebrospinal fluid method under oblongata pond extraction cerebrospinal fluid method, direct-view and look at lower microsyringe straight through endorchis
It punctures and extracts cerebrospinal fluid method acquisition cerebrospinal fluid of rats, to have no blood stains dye for qualification after centrifugation.The acquisition for comparing 3 groups of cerebrospinal fluid is closed
Lattice rate and collection capacity.As a result it is aobvious that success rate and collection capacity of the lower microsyringe through lumbar puncture extraction cerebrospinal fluid method are looked at straight
It writes to be higher than percutaneous puncture oblongata pond extraction cerebrospinal fluid method and scratch endorchis under looking at straight and extracts 2 kinds of method (P of cerebrospinal fluid method
<0.01).It is a kind of convenient and efficient, free of contamination SD that conclusion, which looks at lower microsyringe straight and extracts cerebrospinal fluid method through lumbar puncture,
Cerebrospinal fluid of rats acquisition technique.
But the 3 kinds of methods for taking cerebrospinal fluid referred in document, are not all suitable for multipoint acquisition and continuous acquisition cerebrospinal fluid
Pharmacokinetic studies.
Utility model content
The utility model technical issues that need to address are to provide a kind of for continuous acquisition rat brain ridge under narcosis
The fixator of liquid, the fixator can effectively fix animal head, keep the collection point being repeated several times when sampling more accurate, avoid
Because sampling failure caused by the shakiness of head.
In order to solve the above-mentioned technical problem, the utility model provides a kind of for continuous acquisition rat brain ridge under narcosis
The fixator of liquid, including fixed station, conduit, anesthesia chamber and adjusting bracket；
The conduit is connect with anesthesia chamber, and anesthetic gases enter anesthesia chamber through conduit；
The top edge of the anesthesia chamber open end is longer than lower edge, and open end is in arc-shaped；
The anesthesia chamber connect with fixed station by an elastic device, realized by the elastic device anaesthetize chamber open end to
Lower pressing；
The adjusting bracket is opposite with anesthesia chamber open end, is installed on fixed station；
The adjusting bracket includes a height adjustment axis and two width adjusting axis, and one end of the two width adjustings axis can live
Dynamic is installed on fixed station, and two width adjusting axis can be moved horizontally relative to height adjustment axis；The height adjustment axis can phase
Width adjusting axis is moved up and down in vertical direction；
The anesthesia chamber is semi-cylindrical shaped as a preferred technical solution, and bottom is flat.
The anesthesia chamber open end is apart from adjusting bracket 2cm as a preferred technical solution,.
The top of the height adjustment axis is circle as a preferred technical solution,.
Tune of height adjustment axis when vertical direction moves up and down, apart from fixed station as a preferred technical solution,
Adjusting range is 1cm~4cm.
When the two width adjustings axis is moved horizontally relative to height adjustment axis as a preferred technical solution, the two it
Between adjustable range be 1.5cm~5.5cm.
Fixed animal snout, the height when anesthesia chamber open end presses down on as a preferred technical solution,
Animal neck angle is adjusted when adjustment axis moves up and down, fixed animal skull two sides when the two width adjustings axis moves horizontally.
The fixator for continuous acquisition cerebrospinal fluid of rats under narcosis of the utility model, its advantages include:
1. pressing down on fixed snout by anesthesia chamber open end, the fixed animal neck angle of height adjustment axis is adjusted,
The fixed skull two sides of two width adjusting axis are adjusted, realize the fixation to animal head, present apparatus structure is simple, and it is at low cost, it can
It is widely popularized.
2. the utility model can be realized and animal head is fixed, it can be used for continuous acquisition cerebrospinal fluid under narcosis,
It can avoid because sampling failure caused by the shakiness of head.
3. the fixator technical operation of the utility model is simple, a large amount of training is eliminated, animal can be saved.
4. the fixator of the utility model can realize the operational standardization fixed to animal head, it is poor to advantageously reduce experiment
Different and experimenter operates the influence to experiment of individual factor.
5. the fixator sampling quality using the utility model is high, reduce experimental pollution.
Detailed description of the invention
Fig. 1 is a kind of embodiment of fixator for continuous acquisition cerebrospinal fluid of rats under narcosis of the utility model
Structural schematic diagram.
Sign flag illustrates in attached drawing:
1 is fixed station, and 2 be conduit, and 3 be anesthesia chamber, and 4 be height adjustment axis, and 5 be width adjusting axis, and 6 be elastic device.
Specific embodiment
Clear, complete description is carried out to the technical solution of the utility model below in conjunction with attached drawing, it is clear that described
Embodiment is a part of the embodiment of the utility model, instead of all the embodiments.Based on the embodiments of the present invention,
Those of ordinary skill in the art's every other embodiment obtained without making creative work belongs to this
The range of utility model protection.
As shown in Figure 1, a kind of fixator for continuous acquisition cerebrospinal fluid of rats under narcosis, including fixed station 1, lead
Pipe 2, anesthesia chamber 3 and adjusting bracket (including 4 and 5).Wherein, conduit 2 is connect with the rear end of anesthesia chamber 3, and anesthetic gases are through conduit 2
Into anesthesia chamber 3.The front end for anaesthetizing chamber 3 is anesthesia chamber open end, and the top edge for anaesthetizing chamber open end is longer than lower edge, open end
In arc-shaped.
In a preferred embodiment, anesthesia chamber 3 is semi-cylindrical shaped, bottom flat.It anaesthetizes chamber 3 and passes through an elastic device
6 connect with fixed station 1, for example are attached by a spring.When the top edge of pressing anesthesia chamber open end, anesthesia chamber opening
End can push and cover on animal nose and mouth, carry out continuous narcosis to animal by the anesthetic gases accessed in conduit 2.
Adjusting bracket include a height adjustment axis 4 and two width adjusting axis 5, adjusting bracket relative to anesthesia chamber open end,
It is installed on the edge of fixed station.One end of two width adjusting axis 5 is mobilizable to be installed on fixed station 1, two width adjustings
Axis 5 can be moved horizontally relative to height adjustment axis 4, and height adjustment axis 4 can be relative to width adjusting axis 5 in moving down in vertical direction
It is dynamic.
A kind of enforceable mounting means of adjusting bracket is, in a horizontal slide rail, two width tune are arranged on fixed station 1
Nodal axisn 5 is installed in the horizontal slide rail, it can be achieved that moving horizontally and fixing.Two width adjusting axis 5 are axially arranged with longitudinal cunning
Rail, height adjustment axis 4 are inserted into the longitudinal slide rail by plug-in unit and realize moving up and down and fixing for vertical direction.
In order to be suitable for the figure of experimental animal, the size of fixed station may be configured as high 4cm × wide 10cm × long 15cm, fiber crops
Distance of the liquor-saturated chamber open end apart from adjusting bracket is 2cm, and height adjustment axis 4 is when vertical direction is adjusted, apart from fixed station
Adjustable range be 1cm~4cm, when two 5 horizontal directions of width adjusting axis are adjusted, adjustable range between the two is
1.5cm~5.5cm.
The fixator for continuous acquisition cerebrospinal fluid of rats under narcosis of the utility model, by anaesthetizing chamber open end
Fixed snout is pressed down on, is anaesthetized and intracavitary poured anesthetic gases through conduit and make animal continuous narcosis；By adjusting height adjustment
Axis fixes animal neck angle, so that the head of animal is in preferable state and facilitates acquisition, then adjusts two width adjusting axis and consolidate
To determine skull two sides, animal head is made to realize fixation in adjusting bracket, present apparatus structure is simple, and it is at low cost, it can be widely popularized, Gu
Determine effect stability, can be used for continuous acquisition cerebrospinal fluid under narcosis, because head is unstable during can avoid continuous several times sampling
Sampling is caused to fail.
In conclusion the various embodiments described above and attached drawing are only the preferred embodiment of the utility model, not to limit
Determine the protection scope of the utility model, within the spirit and principle of the utility model, any modification for being made equally is replaced
It changes, improve, all should include within the protection scope of the present utility model.
Claims (7)
1. a kind of fixator for continuous acquisition cerebrospinal fluid of rats under narcosis, which is characterized in that including fixed station, lead
Pipe, anesthesia chamber and adjusting bracket；
The conduit is connect with anesthesia chamber, and anesthetic gases enter anesthesia chamber through conduit；
The top edge of the anesthesia chamber open end is longer than lower edge, and open end is in arc-shaped；
The anesthesia chamber is connected by an elastic device with fixed station, realizes that anesthesia chamber open end is pressed downwards by the elastic device
Pressure；
The adjusting bracket is opposite with anesthesia chamber open end, is installed on fixed station；
The adjusting bracket includes a height adjustment axis and two width adjusting axis, and one end of the two width adjustings axis is mobilizable
It is installed on fixed station, two width adjusting axis can be moved horizontally relative to height adjustment axis；The height adjustment axis can be relative to
Width adjusting axis is moved up and down in vertical direction.
2. fixator as described in claim 1, which is characterized in that the anesthesia chamber is semi-cylindrical shaped, and bottom is flat.
3. fixator as described in claim 1, which is characterized in that the anesthesia chamber open end is apart from adjusting bracket 2cm.
4. fixator as described in claim 1, which is characterized in that the top of the height adjustment axis is circle.
5. fixator as described in claim 1, which is characterized in that the height adjustment axis when vertical direction moves up and down,
Adjustable range apart from fixed station is 1cm~4cm.
6. fixator as described in claim 1, which is characterized in that the two width adjustings axis is horizontal relative to height adjustment axis
When mobile, the adjustable range between two width adjusting axis is 1.5cm~5.5cm.
7. fixator as described in claim 1, which is characterized in that fixed animal mouthful when the anesthesia chamber open end presses down on
Nose, adjusts animal neck angle when the height adjustment axis moves up and down, the two width adjustings axis is fixed when moving horizontally
Animal skull two sides.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721027484.4U CN208404957U (en) | 2017-08-16 | 2017-08-16 | Fixator for continuous acquisition cerebrospinal fluid of rats under narcosis |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201721027484.4U CN208404957U (en) | 2017-08-16 | 2017-08-16 | Fixator for continuous acquisition cerebrospinal fluid of rats under narcosis |
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| CN208404957U true CN208404957U (en) | 2019-01-22 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107468370A (en) * | 2017-08-16 | 2017-12-15 | 上海药明康德新药开发有限公司 | Fixator for continuous acquisition cerebrospinal fluid of rats under narcosis |
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2017
- 2017-08-16 CN CN201721027484.4U patent/CN208404957U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107468370A (en) * | 2017-08-16 | 2017-12-15 | 上海药明康德新药开发有限公司 | Fixator for continuous acquisition cerebrospinal fluid of rats under narcosis |
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