CN208372534U - A kind of blood constituent automatic separating apparatus - Google Patents
A kind of blood constituent automatic separating apparatus Download PDFInfo
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- CN208372534U CN208372534U CN201820490273.2U CN201820490273U CN208372534U CN 208372534 U CN208372534 U CN 208372534U CN 201820490273 U CN201820490273 U CN 201820490273U CN 208372534 U CN208372534 U CN 208372534U
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Abstract
The utility model provides a kind of blood constituent automatic separating apparatus, including up-narrow and down-wide whole blood bag and separation bag wide at the top and narrow at the bottom；Whole blood bag enters separation bag by separation bag top surface and extends to narrow bottom portion along the inner wall of separation bag in whole blood bag top surface opening setting blood inlet and the first conduit, the first conduit, and the first conduit is provided with the first valve；The second conduit, the external positive pressure air bag of the second conduit is arranged in top opening in separation bag, and the second conduit is provided with the second valve；Separation bag is open in gradual change portion is arranged third conduit, and third conduit is connected to by bottom with whole blood bag, and third conduit is provided with third valve；Separation bag is provided with delivery line in the upper end of narrow bottom portion.
Description
Technical field
The utility model belongs to blood constituent separation technology field more particularly to a kind of blood constituent automatic separating apparatus.
Background technique
Blood product is divided into whole blood and component blood, and the needs based on clinical patients or clinical research, blood product or more
Ingredient blood product after the single component for being separated, being obtained high-purity sometimes for being applied.Blood constituent separation usually benefit
With method physically or chemically, the element of the first species's Relatively centralized for being closer to specific gravity form forms several layers (in closing blood bag
Anticoagulant whole blood can be divided into several layers of under certain condition), then be successively diverted to the blood constituent of different levels by transfer pipe
In other containers, to obtain more pure composition blood product.Blood is mostly used to extract dress currently, blood constituent is automatically separated
It sets, realized by gradient centrifugation.It is obtained specifically, blood product is fitted into test tube or blood bag using gradient centrifugation.In addition,
Acquisition can be stood so that the sedimentation agents such as hydroxyethyl starch to be added in blood product, or hydroxyethyl starch is added in blood product
Gradient centrifugation obtains again.
Existing widely used blood constituent separates blood bag, and bag body is in rectangle, bag body upper end be arranged filling tube, transfer pipe,
Blood transfusion socket and heparin tube, the eyelet for suspension are typically disposed in the high frequency sealing edges middle section of blood bag bottom end.It is carried out using this blood bag
When blood constituent separates, it can have the following problems.
Firstly, deficiency the most outstanding is exactly that bag body upper end inner edge is rough, and bag body inner wall often occurs due to gravity
Fold so that some haemocytes by sedimentation after remain adhered to this, generate the stagnant extension phenomenon of attached wall, thus be difficult to it is isolated more
Pure composition blood product, and then serious adverse reaction is brought to infusion object.
Secondly as blood bag is rectangle blood bag, opposite be transferred out of of layering interfaces is made a slip of the tongue greatly, when blood constituent interface is very thin
When-such as tunica albuginea layer (including blood platelet and leucocyte), it is difficult all to shift corresponding component blood, unless by following component blood
It squeezes out together.So when extracting leucocyte using the technique device, after blood cell sedimentation separation, due to the leucocyte interface of formation
It is too thin, it can not further be efficiently separated with red blood cell, cause operating procedure is complicated, red blood cell is easily mixed into, leucocyte is easy to be lost etc.
Problem, or even have to (such as assist using lymphocyte separation medium chemical substance using some cytotoxic additives
Gradient centrifugation be centrifuged repeatedly washing and removes the separating liquid, can be only achieved mitigation cytotoxicity, safe separating purpose, but because
This causes operating process time-consuming and laborious, and leucocyte harvests quantity or quality is not high), or it is white thin using membrane filtration method harvest
Born of the same parents (but because needing repeated flushing, so ineffective), in turn result in the purity and inefficient problem of leucocyte.In addition,
After the blood bag infusion of this structure, there is a small amount of ingredient to be detained in bag, cause to waste.
Third carries out the separation of Multiple components using above-mentioned blood bag, it is necessary to by being repeatedly centrifuged, manually or mechanically assisting
Squeezing transfer can be only achieved purpose, in addition to wasting a large amount of manpower and material resources and time, and blood cell be centrifuged repeatedly will increase from
Heart damage, it is serious to will cause erythrocyte hemolysis, especially in blood cell after cryopreservation.
Therefore, existing blood constituent separation blood bag is further improved.
Utility model content
The purpose of this utility model is to provide a kind of blood constituent automatic separating apparatus, it is intended to solve existing blood constituent
Attached wall existing for separation blood bag is stagnant to be hung, is difficult to separate thin layer blood constituent and cumbersome problem.
The utility model is realized in this way a kind of blood constituent automatic separating apparatus, including up-narrow and down-wide whole blood bag
With separation bag wide at the top and narrow at the bottom, the whole blood bag includes the first bottom, the first gradual change portion and narrow tip portion, first gradual change portion
Cavity bore far from first bottom direction on tapered setting, the narrow tip portion by first gradual change portion extend
It is formed, and the first top surface including being located at top；The separation bag includes the second top, the second gradual change portion and narrow bottom portion,
The tapered setting on the direction far from second top of the cavity bore in second gradual change portion, the narrow bottom portion is by described
Second gradual change portion extends to form, and the second bottom surface including being located at least significant end, and second top includes positioned at the of top
Two top surfaces；
The whole blood bag is in the first conduit that first top surface setting blood inlet at opening and is communicated with the separation bag, institute
The first conduit is stated to enter the separation bag by second top surface and extend to along the inner wall of the separation bag described narrow
Narrow bottom, first conduit are provided with the first valve；The second conduit, institute is arranged in second top opening in the separation bag
The external positive pressure air bag of the second conduit is stated, and second conduit is provided with the second valve；The separation bag described second gradually
Change portion opening setting third conduit, the third conduit is connected to by first bottom with the whole blood bag, and the third
Conduit is provided with third valve；The separation bag is provided with delivery line in the upper end of the narrow bottom portion.
Further, in the separation bag, the nozzle height of first conduit is lower than second conduit, third conduit
With the nozzle height of the delivery line.
Further, the inner wall surface of the separation bag and/or the whole blood bag is smooth.
Further, the separation bag is separation bag of the inner wall surface Jing Guo silicidation；And/or
The whole blood bag is whole blood bag of the inner wall surface Jing Guo silicidation.
Further, bulb, the cavity mouth of the bulb is arranged in the bottom end of the narrow bottom portion in the separation bag
Diameter cumulative setting on the direction close to second bottom surface, and it is less than the cavity bore at second top.
Further, the whole blood bag and the separation bag are integrated bag.
Further, the bag integrating is provided with overlap on bag body periphery, and hole is arranged on the overlap.
Further, the whole blood bag and the separation bag are relatively independent disjunctor bag.
Blood constituent automatic separating apparatus provided by the utility model, including up-narrow and down-wide whole blood bag and wide at the top and narrow at the bottom
Separation bag, and the whole blood bag is provided with the narrow tip portion, therefore, blood constituent circle that is formed at the top of the whole blood bag
Face relative thickness obviously increases, and therefore, can effectively solve the problems, such as that tunica albuginea layer is difficult to efficient high-purity separation transfer；Meanwhile
When carrying out blood constituent separation using blood constituent automatic separating apparatus described in the utility model, first conduit, second are led
The setting of structure and its position is closed in pipe, third conduit and export, and it is continuous unbroken automatic for can making entire centrifugal process
Program is separated, the blood constituent purity and absolute quantity that the primary centrifugation under automatically controlling in this way obtains are better than the past skill
Art, and reducing largely due to being once centrifuged because of balance bag body, the workflows such as pack, be greatly saved manpower and time at
This.Further, blood constituent automatic separating apparatus provided by the utility model, the inner wall of separation bag and/or the whole blood bag
Surface is smooth, can effectively solve the problems, such as attached wall stagnant extension of the cell in blood bag centrifugal process, thus obtain purity it is higher at
Divide blood, further ensures the safety of infusion object.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of integral type blood constituent automatic separating apparatus provided by the embodiment of the utility model；
Fig. 2 is the structural schematic diagram of integral type blood constituent automatic separating apparatus provided by the embodiment of the utility model；
Fig. 3 is the structural schematic diagram of Contiuum type blood constituent automatic separating apparatus provided by the embodiment of the utility model；
Fig. 4 is that use blood constituent automatic separating apparatus progress blood constituent provided by the embodiment of the utility model divides automatically
From when, whole blood bag merge or split the vertical status diagram established after Centrifuge Cup with separation bag；
Fig. 5 is that use blood constituent automatic separating apparatus progress blood constituent provided by the embodiment of the utility model divides automatically
From when, by the first conduit by yellow turbidity layer import separation bag after status diagram；
Fig. 6 is that use blood constituent automatic separating apparatus progress blood constituent provided by the embodiment of the utility model divides automatically
From when, multiple gradient centrifugation export yellow turbidity layer after status diagram；
Fig. 7 is that use blood constituent automatic separating apparatus progress blood constituent provided by the embodiment of the utility model divides automatically
From when, using positive pressure air bag carry out pressurized treatments status diagram；
Fig. 8 is that use blood constituent automatic separating apparatus progress blood constituent provided by the embodiment of the utility model divides automatically
From when, whole blood bag merge or split the vertical status diagram established after Centrifuge Cup with separation bag；
Fig. 9 is provided by the embodiment of the utility model using the progress blood separation of integral type blood constituent automatic separating apparatus
Afterwards, blood constituent status diagram in bag；
Figure 10 is provided by the embodiment of the utility model using Contiuum type blood constituent automatic separating apparatus progress blood point
From blood constituent status diagram in rear, bag.
Specific embodiment
In order to which the technical problems to be solved in the utility model, technical solution and beneficial effect is more clearly understood, below
In conjunction with the embodiments, the present invention will be further described in detail.It should be appreciated that specific embodiment described herein is only
To explain the utility model, it is not used to limit the utility model.
In conjunction with Fig. 1-3, the utility model embodiment provides a kind of blood constituent automatic separating apparatus, including up-narrow and down-wide
Whole blood bag 1 and separation bag 2 wide at the top and narrow at the bottom, whole blood bag 1 include the first bottom 101, the first gradual change portion 102 and narrow tip portion
103, the tapered setting on the direction far from the first bottom 101 of the cavity bore in the first gradual change portion 102, narrow tip portion 103 is by the
One gradual change portion 102 extends to form, and the first top surface 1031 including being located at top；Separation bag 2 includes the second top 201, the
The cavity bore of two gradual change portions 202 and narrow bottom portion 203, the second gradual change portion 202 is tapered on the direction far from the second top 201
Setting, narrow bottom portion 203 are extended to form by the second gradual change portion 202, and the second bottom surface 2031 including being located at least significant end, the second top
Portion 201 includes positioned at the second top surface 2011 of top；
In the first conduit 4 that the first top surface 1031 setting blood inlet 3 at opening and is communicated with separation bag 2, first leads whole blood bag 1
Pipe 4 enters separation bag 2 by the second top surface 2011 and extends to narrow bottom portion 203 along the inner wall of separation bag 2, and first leads
Pipe 4 is provided with the first valve 5；Separation bag 2 is in 201 opening the second conduit 6 of setting of the second top, the external positive pressure of the second conduit 6
Air bag 7, and the second conduit 6 is provided with the second valve 8；Separation bag 2 is open in the second gradual change portion 202 is arranged third conduit 9, third
Conduit 9 is connected to by the first bottom 101 with whole blood bag 1, and third conduit 9 is provided with third valve 10；Separation bag 2 is at narrow bottom
203 upper ends in portion are provided with delivery line 11.
In the utility model embodiment, up-narrow and down-wide 1 structure of whole blood bag, so that 1 higher slice interface of whole blood bag is opposite
It reduces, so that the blood constituent of content such as leucocyte, blood platelet can form the apparent layer knot of thickness when interface is enriched with
Structure such as tunica albuginea layer, and then be conducive to its transfer.Based on same reason, separation bag 2 is arranged to structure wide at the top and narrow at the bottom.
Further, in whole blood bag 1, narrow tip portion 103 is extended to form by the first gradual change portion 102, and narrow tip portion 103 can be with
It is further formed tapered configuration, cavity caliber size can also be kept constant.Based on same reason, in separation bag 2, narrow bottom
Portion 203 is extended to form by the second gradual change portion 202, and narrow bottom portion 203 can be further formed tapered configuration, can also keep cavity
Caliber size is constant.Although the height of narrow tip portion 103 without strictly limiting, preferably obtains in limited height longer
Narrow tip portion 103, with storage accumulate leucocyte blood platelet, further, narrow tip portion 103 is longer, in leucocyte granulocyte and
The little cell accumulation layering of monocyte lymphocyte isodensity bulk & form difference is just thicker (such as mononuclear cell layer 3mm is thick)
It is apparent, the stratification state of more preferable isolation extraction is created to obtain high-purity monocyte or lymphocyte or blood platelet.
Further, bulb 204, the cavity bore of bulb 204 is arranged in the bottom end of narrow bottom portion 203 in separation bag 2
The cumulative setting on the direction close to the second bottom surface 2031, and less than the cavity bore at the second top 201.Due to relatively red thin
Born of the same parents, the amount and volume of leucocyte blood platelet are all very littles in whole blood, and the rich ingredient blood plasma isolated for the first time is inevitable every time
Some red blood cell residual.Therefore, these red blood cells can be made to be deposited on 2 bottom of separation bag one using this design larger
Region (bulb 204), and then leucocyte and platelet layer is allowed to be deposited in narrow bottom portion 203 as far as possible, in this way could high-purity
Separation intercept these ingredients.Further, since the height of Centrifuge Cup is limited, for example usual large capacity Centrifuge Cup height is about
10cm or so, therefore in order to obtain longer narrow positions in limited height as far as possible, it is small with storage accumulation leucocyte blood
Plate, further, narrow zone are longer, and granulocyte and monocyte lymphocyte isodensity bulk & form difference is not in leucocyte
Big cell accumulation layering just thicker (such as mononuclear cell layer 3mm is thick) is apparent, thin to obtain high-purity monocyte or lymph
Born of the same parents or blood platelet create the stratification state that more preferable isolation is extracted.
It is further preferred that the inner wall surface of separation bag 2 and/or whole blood bag 1 is smooth, the design in smooth inner wall face can be with
Prevent blood constituent such as haemocyte after sedimentation adherency at fold, generate the attached stagnant extension phenomenon of wall.Still more preferably separate
The inner wall surface of bag 2 is smooth.Specific preferred, separation bag 2 is separation bag 2 of the inner wall surface Jing Guo silicidation；And/or whole blood
Bag 1 is whole blood bag 1 of the inner wall surface Jing Guo silicidation.It handles by surface siliconization, is such as needed point when separating blood constituent
It (especially needs smooth), can be activated when from blood platelet to avoid blood platelet.If acquiring blood to need to save transport for a long time,
Such as more than six hours, then other whole blood bag is needed to save the whole blood of acquisition, the whole blood separation of silication is then transferred in separation
It is separated in bag, because the surface of silication is airtight, red blood cell is difficult to save for a long time, it may occur that haemolysis.
In the utility model embodiment, whole blood bag 1 the first top surface 1031 be open setting blood inlet 3 and with 2 phase of separation bag
The first logical conduit 4, blood inlet 3 and the first conduit 4 can be respectively set in the first top surface 1031, can also both share one
Be open Hou Zai branch two pipeline structures of formation.In a specific embodiment, blood inlet 3 and the first conduit 4 are in the first top surface
After a 1031 shared openings, branch forms two pipeline structures again.
Further, the first conduit 4 enters separation bag 2 by the second top surface 2011 and prolongs along the inner wall of separation bag 2
Extend to narrow bottom portion 203.Thus it is more conducive to the progress of blood constituent automatic separating apparatus heat seal production technology, and is avoided at pipeline
In bag body inner cavity cause cell wall built-up, separation purity decline the problem of.First conduit 4 is opening down, and height setting can basis
The baseline of tunica albuginea stack layer is likely to form with reference to setting, and is lower than the baseline of tunica albuginea stack layer.Preferably, the pipe of the first conduit 4
Open height is inevitably less than the nozzle height of the second conduit 6, third conduit 9 and delivery line 11, so that drawing every time from whole blood bag 1
Stream the rich leucocyte thrombocyte plasma including a small amount of red blood cell, into after separation bag 2, red blood cell under the influence of centrifugal force,
Continue to move down, other compositions then move relatively upward, in this way guarantee the first conduit 4 heap near 2 delivery line 11 of separation bag
Product harvest leukocytic cream, platelet layer, plasma layer, maximum possible reduce the residual of red blood cell.
Further, the first conduit 4 is provided with the first valve 5, and the first valve 5 is for controlling blood constituent from whole blood bag
1 arrives the drainage of separation bag 2.The setting position of first valve 5 does not clearly require, and may be provided at the middle section of the first conduit 4, or
Endpiece far from whole blood bag 1 or another endpiece far from separation bag 2.
In the utility model embodiment, for separation bag 2 in 21 opening the second conduit 6 of setting of the second top, the second conduit 6 is external
One positive pressure air bag 7.The setting of the structure can pass through positive pressure air bag 7 and pressurize when plasma layer content is excessive in separation bag, will
Blood plasma in separation bag 2 is introduced into whole blood bag 1 by third conduit 9.Nozzle height of second conduit 6 in separation bag 2 does not have
Stringent limitation, as long as being able to achieve above-mentioned function.It is, of course, preferable to be more shorter better, when blood interface is higher in separation bag 2
Still it can carry out, and not influence layered structure.Second conduit 6 is provided with the second valve 8, for opening or blocking air pressure logical
Road.The setting position of second valve 8 does not clearly require, and may be provided at the middle section of the second conduit 6, or far from positive pressure air bag 7
Endpiece or far from separation bag 2 another endpiece.
In the utility model embodiment, separation bag 2 is open in the second gradual change portion 202 is arranged third conduit 9, third conduit 9
It is connected to by the first bottom 101 with whole blood bag 1.By third conduit 9, the blood plasma in separation bag 2 can be passed through into third conduit 9
It is introduced into whole blood bag 1, the relatively true plasma that third conduit 9 is higher by separation bag 2 is transferred in 1 bottom section of whole blood bag and blood bag
Red blood cell re-mixes, and by repeatedly such operation, is originally deposited on blood platelet that 1 bottom of whole blood bag can not rise, white thin
The ingredients such as born of the same parents are more fully extracted.Third conduit 9 is provided with third valve 10, for controlling blocking or the company of third conduit 9
Logical, the setting position of third valve 10 does not clearly require, and may be provided at the middle section of third conduit 9, or far from whole blood bag 1
Another endpiece of endpiece or separate separation bag 2.
In the utility model embodiment, separation bag 2 is provided with delivery line 11, delivery line 11 in 203 upper ends of narrow bottom portion
Can external one or more component collection bags, for each blood constituent to be collected.
As a specific embodiment, as shown in Figure 1, 2, the blood constituent automatic separating apparatus is structure as a whole, i.e.,
Whole blood bag 1 and separation bag 2 are integrated bag.Wherein, two before and after the blood constituent automatic separating apparatus bag that Fig. 1 is an integral structure
Face, left side figure are the back side, and right figure is front；Before and after the blood constituent automatic separating apparatus bag that Fig. 2 is an integral structure
Left side back side figure, is normally folded into the back side of right side elevation shape, intermittent line part is integrated the back of bag by two sides overlapping figure
Face.When blood constituent automatic separating apparatus is structure as a whole, the curved surface inner sidewall of whole blood bag 1 and separation bag 2 can in bag integrating
It is public completely or partially, so as to save material, heat seal is facilitated to process, obtain bag body that is compact-sized, facilitating suspension strut.
It is further preferred that the bag integrating is provided with overlap 12 on bag body periphery, hole 121 is set on overlap 12.
The setting of the structure can keep bag body consistent with the level in centrifugal force direction, folding or gauffer will not occur in centrifugation,
Especially narrow positions and nozzle avoid attached wall hanging stagnant.Overlap 12 and hole 121 can also share generated in centrifugal process it is vertical
To pulling force, keeps bag body to remain the complete uniform force of form in centrifugal process, local laceration blood leakage will not occur
Risk.
As another specific embodiment, as shown in figure 3, the blood constituent automatic separating apparatus is conjoined structure, i.e.,
Whole blood bag 1 and separation bag 2 are relatively independent disjunctor bag, specifically, whole blood bag 1 and separation bag 2 can be with left-right situs (whole blood bags
1 can be placed in the left side or the right, and separation bag 2 can be placed in the left side or the right), whole blood bag 1 and separation bag 2 can also be arranged above and below (entirely
Blood bag 1 can be placed on or in the following, separation bag 2 can be placed on or below).
Blood constituent automatic separating apparatus provided by the embodiment of the utility model, including up-narrow and down-wide whole blood bag and upper width
Under narrow separation bag, and the whole blood bag is provided with the narrow tip portion, therefore, the blood formed at the top of the whole blood bag
It is obviously increased at interface relative thickness, therefore, can effectively solve the problems, such as that tunica albuginea layer is difficult to efficient high-purity separation transfer；
Meanwhile when carrying out blood constituent separation using blood constituent automatic separating apparatus described in the utility model embodiment, described first
The setting of structure and its position is closed in conduit, the second conduit, third conduit and export, can make entire centrifugal process be it is continuous not
What is interrupted is automatically separated program, and the blood constituent purity and absolute quantity that the primary centrifugation under automatically controlling in this way obtains are all
Reduce largely better than the past technology, and due to being once centrifuged because of workflows such as balance bag body, packs, people is greatly saved
Power and time cost.Further, blood constituent automatic separating apparatus provided by the embodiment of the utility model, separation bag and/or
The inner wall surface of the whole blood bag is smooth, can effectively solve the problems, such as attached wall stagnant extension of the cell in blood bag centrifugal process, thus
The higher component blood of purity is obtained, further ensures the safety of infusion object.
In conjunction with Fig. 4-10, the utility model embodiment additionally provides a kind of blood constituent automatic separation method, the separation
Method using above-mentioned blood constituent automatic separating apparatus realize, specifically includes the following steps:
S01. whole blood bag 1 is merged with separation bag 2 or split it is vertical establish in Centrifuge Cup, carry out centrifugal treating, shape
State schematic diagram is as shown in Figure 4；
Further, whole blood bag 1 is merged to separation bag 2 or is split vertical establish in Centrifuge Cup through multiple blood bag phases
It mutually squeezes and realizes；Or it is realized using soft material support；Or realized using supporting structure suspension, it is being centrifuged with preventing blood bag
Middle generation fold and the stagnant extension of attached wall.When being realized using supporting structure suspension, overlap 12 need to be reserved and be arranged on overlap 12 empty
Hole 121.
S02. when the whole blood bag 1 is in yellow turbidity layer, the first valve 5 is opened, it will be described by first conduit 4
Yellow turbidity layer imports in the separation bag 2, and status diagram is as shown in Figure 5；
It is centrifuged after a period of time, when sufficiently sedimentation forms one to 1 narrow tip portion of whole blood bag, 13 exit region red blood cell relatively
Determine rich platelet, the leucocyte blood plasma (blood plasma may contain a small amount of red blood cell) of volume, but naked-eye observation be in turbidity compared with
High yellow area opens the first valve 5 at this time, the rich platelet in the region, leucocyte blood plasma can be imported separation bag 2, by
The export of 2 middle and lower part delivery line 11 of separation bag.A small amount of red blood cell remaining in this way falls to separation in the shortest time and apart from interior
The bottom end (such as described bulb) of 2 narrow bottom portions of bag.And the other compositions in rich platelet, leucocyte blood plasma are then according to each
From density, under the action of gradient centrifugation with narrow bottom portion described in separation bag 2 be layered be enriched with.
S03. gradient centrifugation processing is carried out, when red blood cell interface red in the whole blood bag 1 is close to the first top surface 1031,
First valve 5 is closed, when new yellow turbidity layer occurs in the narrow tip portion described in the whole blood bag 1, is again turned on valve
1, and the operation is repeated, status diagram is as shown in Figure 6；
When 1 red blood cell interface of whole blood bag is close to its exit, first valve 5 is closed, can be blocked more red thin
Born of the same parents enter in separation bag 2.It is centrifuged by one section, the red blood cell of narrow tip portion described in 1 middle and upper part of whole blood bag continues to settle, and occurs new
Rich platelet, leucocyte plasma layer.At this point, being again turned on the first valve 5.It repeats above operation, obtains blood as shown in FIG. 6
Liquid is at isloation state: 2 bottom section of separation bag is a small amount of residual red blood cells layer, is thereon tunica albuginea layer, is thereon platelet rich plasma
Layer, is thereon purer plasma layer.
S04. when occurring blood constituent layering in the separation bag 2, and the yellow blood plasma layer height of top layer is more than export
When pipe 11, first valve 5 is closed, the second valve 8 is opened, and pressurized treatments are carried out using positive pressure air bag 7, is then shut off institute
The second valve 8 is stated, status diagram is as shown in Figure 7；
S05. third valve 10 is opened, the yellow blood plasma that third conduit 9 is higher by separation bag 2 is transferred to whole blood bag 1
First bottom, re-mixes, status diagram is as shown in Figure 8 with the ingredient in whole blood bag 1；
Third conduit 9 will be higher by this point, the first valve 5 is also at closed state by opening third valve 10 in separation bag 3
Relatively true plasma be transferred to 1 bottom section of whole blood bag and re-mixed with red blood cell in whole blood bag 1.
S06. the operation of above-mentioned S02 to S05 is repeated, and various blood constituents are collected by the delivery line.
The operation of above-mentioned S02 to S05 is repeated, blood platelet, leucocyte etc. that 1 bottom of whole blood bag can not rise originally are deposited on
Ingredient is more fully extracted.After blood constituent total amount and purity achieve the desired purpose, centrifugal process is terminated, using integral type
After the progress blood separation of blood constituent automatic separating apparatus, blood constituent status diagram is as shown in Figure 9 in bag；Using Contiuum type
After the progress blood separation of blood constituent automatic separating apparatus, blood constituent status diagram is as shown in Figure 10 in bag.Take out whole blood
Bag 1 and separation bag 2, by the delivery line 11 of separation bag 2 by required blood constituent, such as platelet rich plasma, true plasma, tunica albuginea layer
(including granulocyte, lymphocyte or be mononuclearcell), be directed respectively into respective collecting bag.
The above centrifugal process is continuous unbroken separation program, what the primary centrifugation under automatically controlling in this way obtained
Blood constituent purity and absolute quantity are better than the past technology and reduce largely due to being once centrifuged because of balance bag body, pack
Etc. workflows, manpower and time cost is greatly saved.
Blood constituent automatic separation method provided by the embodiment of the utility model, can be by automatically controlling primary realization blood
The separation of ingredient, can not only effectively improve the separation purity of component blood, and manpower and time cost is greatly saved, separation
Efficiency is improved.
The above is only the preferred embodiment of the utility model only, is not intended to limit the utility model, all at this
Made any modifications, equivalent replacements, and improvements etc., should be included in the utility model within the spirit and principle of utility model
Protection scope within.
Claims (8)
1. a kind of blood constituent automatic separating apparatus, which is characterized in that including up-narrow and down-wide whole blood bag and point wide at the top and narrow at the bottom
From bag, the whole blood bag includes the first bottom, the first gradual change portion and narrow tip portion, and the cavity bore in first gradual change portion is remote
Tapered setting on direction from first bottom, the narrow tip portion are extended to form by first gradual change portion, and including position
In the first top surface of top；The separation bag includes the second top, the second gradual change portion and narrow bottom portion, second gradual change portion
Cavity bore far from it is described second top direction on tapered setting, the narrow bottom portion by second gradual change portion extend
It is formed, and the second bottom surface including being located at least significant end, second top includes positioned at the second top surface of top；
The whole blood bag is open setting blood inlet and the first conduit for communicating with the separation bag in first top surface, and described the
One conduit enters the separation bag by second top surface and extends to the narrow bottom along the inner wall of the separation bag
Portion, first conduit are provided with the first valve；The second conduit is arranged in second top opening in the separation bag, and described the
The external positive pressure air bag of two conduits, and second conduit is provided with the second valve；The separation bag is in second gradual change portion
Opening setting third conduit, the third conduit is connected to by first bottom with the whole blood bag, and the third conduit
It is provided with third valve；The separation bag is provided with delivery line in the upper end of the narrow bottom portion.
2. blood constituent automatic separating apparatus as described in claim 1, which is characterized in that in the separation bag, described first
Nozzle height of the nozzle height of conduit lower than second conduit, third conduit and the delivery line.
3. blood constituent automatic separating apparatus as described in claim 1, which is characterized in that the separation bag and/or described complete
The inner wall surface of blood bag is smooth.
4. blood constituent automatic separating apparatus as claimed in claim 3, which is characterized in that the separation bag is inner wall surface warp
Cross the separation bag of silicidation；And/or
The whole blood bag is whole blood bag of the inner wall surface Jing Guo silicidation.
5. blood constituent automatic separating apparatus as described in claim 1, which is characterized in that the separation bag is at the narrow bottom
The bottom end setting bulb in portion, cavity bore cumulative setting on the direction close to second bottom surface of the bulb, and
Less than the cavity bore at second top.
6. blood constituent automatic separating apparatus a method as claimed in any one of claims 1 to 5, which is characterized in that the whole blood bag and described
Separation bag is integrated bag.
7. blood constituent automatic separating apparatus as claimed in claim 6, which is characterized in that the bag integrating is set on bag body periphery
It is equipped with overlap, hole is set on the overlap.
8. blood constituent automatic separating apparatus a method as claimed in any one of claims 1 to 5, which is characterized in that the whole blood bag and described
Separation bag is relatively independent disjunctor bag.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820490273.2U CN208372534U (en) | 2018-04-09 | 2018-04-09 | A kind of blood constituent automatic separating apparatus |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820490273.2U CN208372534U (en) | 2018-04-09 | 2018-04-09 | A kind of blood constituent automatic separating apparatus |
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| CN208372534U true CN208372534U (en) | 2019-01-15 |
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| CN201820490273.2U Expired - Fee Related CN208372534U (en) | 2018-04-09 | 2018-04-09 | A kind of blood constituent automatic separating apparatus |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108579130A (en) * | 2018-04-09 | 2018-09-28 | 深圳市祥平元创科技有限公司 | A kind of blood constituent automatic separating apparatus and separation method |
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2018
- 2018-04-09 CN CN201820490273.2U patent/CN208372534U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108579130A (en) * | 2018-04-09 | 2018-09-28 | 深圳市祥平元创科技有限公司 | A kind of blood constituent automatic separating apparatus and separation method |
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Granted publication date: 20190115 |