CN208346187U - A kind of ultrasonic cell disruption instrument circulating cooling slot device - Google Patents
A kind of ultrasonic cell disruption instrument circulating cooling slot device Download PDFInfo
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- CN208346187U CN208346187U CN201820772810.2U CN201820772810U CN208346187U CN 208346187 U CN208346187 U CN 208346187U CN 201820772810 U CN201820772810 U CN 201820772810U CN 208346187 U CN208346187 U CN 208346187U
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- cooling
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- groove body
- cell disruption
- ultrasonic cell
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Abstract
The utility model discloses a kind of ultrasonic cell disruption instrument circulating cooling slot device, including hollow cooling groove body and the cooling slot cover being covered in cooling bath body openings, inner cavity coaming plate is provided in the cavity of the cooling groove body, there is gap, the cavity of the cooling groove body is divided into the internal cavity and external cavity that top is connected to by the inner cavity coaming plate between the top of the inner cavity coaming plate and the cooling slot cover；It is provided with water inlet on the inner cavity coaming plate, is provided with water outlet on the side plate of the cooling groove body.The utility model passes through the cooling groove body of sandwich, makes coolant liquid direct circulation haptoreaction container, good cooling results are high-efficient, meet the temperature control requirement of ultrasonic cell disruption instrument；Small to the demand of cooling water simultaneously, circulation rate is fast, provides advantage for the integration and miniaturization of ultrasonic cell disruption instrument.
Description
Technical field
The utility model relates to ultrasonic cell disruption instruments, are specifically related to a kind of cooling system of ultrasonic cell disruption instrument
System.
Background technique
Ultrasonic cell disruption instrument also known as ultrasonic-microwave synergic solvent extraction instrument, supersonic cell crack instrument, ultrasonic wave nanometer material
Expect pulverizer.Ultrasonic cell disruption instrument is made of supersonic generator and energy converter two large divisions.Ultrasonic cell disruption instrument
Electric energy is exactly converted into sound energy by energy converter, this energy becomes minute bubbles intensive one by one by liquid medium,
These minute bubbles are burst rapidly, the energy as bomblet of generation, to play the role of the substances such as smudge cells.Ultrasound
Wave cell crushing instrument has disrupting tissue, bacterium, virus, spore and other eucaryotic cell structures, homogeneous, emulsify, mix, deaerating, collapsing
Solution and dispersion are leached and are extracted, and are accelerated the functions such as reaction, therefore are widely used in biology, medicine, chemistry, pharmacy, food, makeup
The laboratory researches such as product, environmental protection and enterprise's production.
Industry popularization of the ultrasonic cell disruption instrument in China has entered the stage of ripeness, but application is still not universal enough.Study carefully it
Reason, although the instrument application range is very extensive, market potential is very big, there is Other Instruments equipment cannot compare excellent
Point.But ultrasonic cell disruption instrument currently on the market still has more defect, such as application No. is
201520105010.1 the patent of entitled Ultrasonic Intelligent cell crushing instrument discloses a kind of Ultrasonic Intelligent clasmatosis
Instrument, including cabinet, top are provided with upper spacer, and lower part is provided with lower clapboard, cabinet is separated by be formed upper box, middle cabinet and under
Cabinet；Side plate, upper spacer, the lower clapboard of cabinet are made of steel plate, in the side plate of middle cabinet described in upper spacer, lower clapboard and composition
Surface is provided with high temperature tetrafluoro coating；The inner cavity of lower box is provided with power supply, transformer and power switch, and power supply passes through transformer
It is connected with power switch；The inner cavity of middle cabinet is provided with container and ultrasonic generator for holding reaction solution, container
There are solid particle or cell in reaction solution, ultrasonic generator sending ultrasonic wave, which acts on reaction solution, makes clasmatosis；Hold
Device is fixed on lower clapboard, and ultrasonic generator is electrically connected with power switch.As can be seen that being integrated with ultrasound in the device
Most of components of wave cell crushing instrument, but ultrasonic wave is a kind of elastic mechanical wave, is both a kind of wave and a kind of energy
Amount form, energy become minute bubbles intensive one by one by liquid medium, these minute bubbles are burst rapidly, and production hinders
The molecular vibration as caused by ultrasound makes portion of energy be converted into local high fever (42-43 DEG C).Ultrasound mainly has the effect of cell
Fuel factor, cavitation effect and mechanical effect.Fuel factor is generated when cavitation bubble ruptures instantaneous high when ultrasound is propagated in the medium
Warm (about 5000 DEG C), high pressure (up to 500 × 104Pa) can make steam pyrolysis from generating .OH free radical and .H atom, by
.OH redox reaction caused by free radical and .H atom can lead to a systems such as polymer degradation, enzyme inactivation, lipid peroxidation
Column substance deactivation.Therefore, for needing to keep for cell lysate (albumen, nucleic acid etc.) active ultrasonic disruption,
It is particularly important to provide low temperature environment.And existing equipment is because without cooling system, temperature control effect is excessively poor.It is asked for this
Topic, there are also producers, and temperature control is carried out by the way of external cooling equipment, but this way leads to equipment overall volume substantially
Degree increases, and structure disperses, use are very inconvenient.
In addition to this, there is also the defects of fixed unstable, installation is inconvenient for existing reaction vessel, similarly to ultrasonic wave
The application of cell crushing instrument causes strong influence.
Summary of the invention
Goal of the invention: the utility model aim is to provide a kind of ultrasonic wave of sandwich in view of the deficiencies of the prior art
Cell crushing instrument circulating cooling slot device provides basis for the integration and miniaturization of ultrasonic cell disruption instrument.
Technical solution: ultrasonic cell disruption instrument circulating cooling slot device described in the utility model, including hollow cooling
Groove body and the cooling slot cover being covered in cooling bath body openings are provided with inner cavity in the cavity of the cooling groove body and enclose
Plate has gap between the top of the inner cavity coaming plate and the cooling slot cover, the cavity of the cooling groove body is by described interior
Chamber coaming plate is divided into the internal cavity and external cavity that top is connected to；
Be provided with water inlet on the inner cavity coaming plate, be provided with water outlet on the side plate of the cooling groove body, it is described into
The internal cavity and external cavity are connected to by the mouth of a river and water outlet with the exterior space of cooling groove body respectively；
The cooling bath is covered to be gone out to be provided with mounting hole with the internal cavity opposite position, ultrasonic cell disruption instrument
Reaction vessel is inserted into the mounting hole, is mounted in the internal cavity.
Further preferably technical solution is the utility model, is provided with if the cooling bath is covered around the mounting hole
Dry latch fitting, the reaction vessel are mounted in the internal cavity, and the oral area of reaction vessel is locked in the cooling by the latch fitting
The position of mounting hole of slot cover.
Preferably, the latch fitting includes clamping jaw and nut, and the clamping jaw is movably arranged on the cooling bath and covers, along close
The direction of the mounting hole or the direction of the separate mounting hole are slided, and the nut passes through the clamping jaw and is inserted into the cooling bath
Lid, is locked at sliding position for the clamping jaw.
Preferably, the nut is wing nut.
Preferably, circulating pump is additionally provided in the external cavity of the cooling groove body, the water outlet passes through the cooling
The side plate of groove body is connect with the circulating pump.
Preferably, the spacing between the top of the inner cavity coaming plate and the cooling slot cover is 1cm.
The utility model has the advantages that the cooling water that (1) the utility model refrigeration machine provides enters the interior of cooling groove body by water inlet
Cavity cools down the reaction vessel being mounted in internal cavity, from the top of internal cavity after cooling water fills up in internal cavity
It is spilled over in external cavity, is discharged by the water outlet of external cavity, form the cooling water flow conduits in cooling groove body, pass through sandwich
Cooling groove body, coolant liquid direct circulation haptoreaction container, good cooling results are high-efficient, meet ultrasonic cell disruption instrument
Temperature control requirement；Meanwhile the circulating cooling slot device of the utility model is small to the demand of cooling water, circulation rate is fast, is super
The integration and miniaturization of sound wave cell crushing instrument provide advantage；
(2) it is covered in the utility model in cooling bath and mounting hole is provided with several latch fittings, held reaction by latch fitting
Device is fixed in cooling groove body, quickly and effectively fixes reaction vessel, stable cooler environment is provided to reaction vessel；
(3) latch fitting includes clamping jaw and nut in the utility model, and clamping jaw is movably arranged on the cooling bath and covers, and passes through
Nut is fixed on sliding position, can freely adjust the locked position of latch fitting according to the size of reaction vessel, versatile.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of circulating cooling slot device described in the utility model；
Fig. 2 is the sectional view of circulating cooling slot device described in the utility model；
In figure, the cooling groove body of 1-, 2- cooling slot cover, the inner cavity 3- coaming plate, 4- water inlet, 5- water outlet, 6- circulating pump, 7-
Reaction vessel, 8- clamping jaw, 9- wing nut.
Specific embodiment
Technical solutions of the utility model are described in detail below by attached drawing, but the protection scope of the utility model
It is not limited to the embodiment.
Embodiment: a kind of ultrasonic cell disruption instrument circulating cooling slot device, including hollow cooling groove body 1 and covering
The cooling slot cover 2 in the opening of groove body 1 is being cooled down, is being provided with inner cavity coaming plate 3 in the cavity of cooling groove body 1, inner cavity coaming plate 3
The cavity in the gap with 1cm between top and cooling slot cover 2, cooling groove body 1 is divided into what top was connected to by inner cavity coaming plate 3
Internal cavity and external cavity.Wherein internal cavity is as cooling chamber, and external cavity is as storage chamber.
It is provided with water inlet 4 on inner cavity coaming plate 3, is provided with water outlet 5,4 He of water inlet on the side plate of cooling groove body 1
Internal cavity and external cavity are connected to by water outlet 5 with the exterior space of cooling groove body 1 respectively, in the external cavity of cooling groove body 1
It is additionally provided with circulating pump 6, the side plate that water outlet 5 passes through cooling groove body 1 is connect with circulating pump 6.When coolant liquid passes through water inlet 4
Reaction solution when cooling chamber, in the cooling reaction vessel 7 of coolant liquid；It is cold when coolant liquid is higher than the height of inner cavity coaming plate 3
But liquid overflows into storage chamber.Refrigerator and water pipe are set between water inlet 4 and water outlet 5, coolant liquid is recycled cold
But.
In cooling slot cover 2 with mounting hole is provided at internal cavity opposite position, the reaction of ultrasonic cell disruption instrument is held
Device 7 is inserted into mounting hole, is mounted in internal cavity.Mounting hole is provided with several latch fittings in cooling slot cover 2, reaction vessel 7
Oral area is locked in the position of mounting hole of cooling slot cover 2 by latch fitting.Latch fitting includes clamping jaw 8 and wing nut 9,8 activity installation of clamping jaw
In cooling slot cover 2, slided along the direction close to mounting hole or the direction far from mounting hole, wing nut 9 is inserted into across clamping jaw 8
Cooling slot cover 2, is locked at sliding position for clamping jaw 8.The installation of reaction vessel 7 is clamped to be completed by clamping jaw 8, and wing nut 9 is used
In stationary jaw 8.
As described above, although the utility model has been indicated and described referring to specific preferred embodiment, it must not
It is construed to the limitation to the utility model itself.In the spirit and scope for not departing from the utility model that appended claims define
Under the premise of, it can various changes can be made in the form and details to it.
Claims (6)
1. a kind of ultrasonic cell disruption instrument circulating cooling slot device, which is characterized in that including hollow cooling groove body and cover
The cooling slot cover in cooling bath body openings is covered, inner cavity coaming plate, the inner cavity are provided in the cavity of the cooling groove body
There is gap, the cavity of the cooling groove body is divided by the inner cavity coaming plate between the top of coaming plate and the cooling slot cover
The internal cavity and external cavity of top connection；
It is provided with water inlet on the inner cavity coaming plate, water outlet, the water inlet are provided on the side plate of the cooling groove body
The internal cavity and external cavity are connected to the exterior space of cooling groove body respectively with water outlet；
The cooling bath covers and is provided with mounting hole, the reaction of ultrasonic cell disruption instrument at the internal cavity opposite position
Container is inserted into the mounting hole, is mounted in the internal cavity.
2. ultrasonic cell disruption instrument circulating cooling slot device according to claim 1, which is characterized in that the cooling bath
It covers and the mounting hole is provided with several latch fittings, the reaction vessel is mounted in the internal cavity, the mouth of reaction vessel
Portion is locked in the position of mounting hole of the cooling slot cover by the latch fitting.
3. ultrasonic cell disruption instrument circulating cooling slot device according to claim 2, which is characterized in that the latch fitting packet
Clamping jaw and nut are included, the clamping jaw is movably arranged on the cooling bath and covers, along the direction close to the mounting hole or far from institute
The direction sliding of mounting hole is stated, the nut passes through the clamping jaw and is inserted into the cooling slot cover, and the clamping jaw is locked at sliding
Position.
4. ultrasonic cell disruption instrument circulating cooling slot device according to claim 3, which is characterized in that the nut is
Wing nut.
5. ultrasonic cell disruption instrument circulating cooling slot device according to claim 1, which is characterized in that the cooling bath
Circulating pump is additionally provided in the external cavity of main body, the water outlet passes through the side plate of the cooling groove body and the circulating pump connects
It connects.
6. ultrasonic cell disruption instrument circulating cooling slot device according to claim 1, which is characterized in that enclose the inner cavity
Spacing between the top of plate and the cooling slot cover is 1cm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820772810.2U CN208346187U (en) | 2018-05-22 | 2018-05-22 | A kind of ultrasonic cell disruption instrument circulating cooling slot device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820772810.2U CN208346187U (en) | 2018-05-22 | 2018-05-22 | A kind of ultrasonic cell disruption instrument circulating cooling slot device |
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| Publication Number | Publication Date |
|---|---|
| CN208346187U true CN208346187U (en) | 2019-01-08 |
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ID=64890207
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| Application Number | Title | Priority Date | Filing Date |
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| CN201820772810.2U Active CN208346187U (en) | 2018-05-22 | 2018-05-22 | A kind of ultrasonic cell disruption instrument circulating cooling slot device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113293099A (en) * | 2021-06-01 | 2021-08-24 | 中国科学院重庆绿色智能技术研究院 | Device for researching interaction between micro-nano bubbles and cells |
-
2018
- 2018-05-22 CN CN201820772810.2U patent/CN208346187U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113293099A (en) * | 2021-06-01 | 2021-08-24 | 中国科学院重庆绿色智能技术研究院 | Device for researching interaction between micro-nano bubbles and cells |
| CN113293099B (en) * | 2021-06-01 | 2023-12-22 | 中国科学院重庆绿色智能技术研究院 | Method for researching interaction between micro-nano bubbles and cells |
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