CN208239383U - A kind of anti-complement activity test experience hemolysin titration device - Google Patents
A kind of anti-complement activity test experience hemolysin titration device Download PDFInfo
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- CN208239383U CN208239383U CN201820829922.7U CN201820829922U CN208239383U CN 208239383 U CN208239383 U CN 208239383U CN 201820829922 U CN201820829922 U CN 201820829922U CN 208239383 U CN208239383 U CN 208239383U
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- pipe
- hemolysin
- titration
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- drop tube
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Abstract
The utility model provides a kind of anti-complement activity test experience hemolysin titration device, including two support rods being vertically arranged fixed in support plate and support plate, buret is equipped between two support rods, sequentially connected hose and closed-entry diversion pipe are equipped in buret outlet end, wherein hose is circulated by control assembly interval, draft tube outlets end, which is communicated with to subtract, swings pipe and draft tube outlets fitting subtracts and swings inside pipe wall, subtract and swings the drop tube that pipe is communicated with formed linker, drop tube includes multistage vertical pipe, it is connected between adjacent two vertical pipe by circular arc tube transitions, it is drop tube outlet end positioned at the vertical pipe lower end of last installation site, titration bottle is equipped with below drop tube outlet end, titration bottle passes through the rotation of concussion Component driver and concussion.Control assembly can guarantee that hemolysin is added dropwise to the rate of addition in sheep erythrocyte suspension, and concussion component can control the rotation of sheep erythrocyte suspension, oscillation frequency in titration bottle, improve the repeatability of hemolysin titration experiment.
Description
Technical field
The utility model relates to medicinal detection technique fields, and in particular to a kind of anti-complement activity test experience hemolysin
Titration outfit.
Background technique
Having a step in the experiment of anti-complement activity detection is the titration of hemolysin, and comprising the concrete steps that will be after dilution
Hemolysin takes a certain amount of a certain amount of 5% sheep erythrocyte suspension of being slowly added dropwise to be mixed, and after 37 DEG C are placed 30 minutes, adds
Enter gelatin barbitol buffer solution and diluted guinea pig complement solution, then placed 60 minutes at 37 DEG C, is then centrifuged, takes
Supernatant liquor carries out spectrophotometry and tests to obtain the absorbance of mixed liquor；In the prior art, that hemolysin is added dropwise to sheep is red
It is by manual operation in cell suspension, operator is Shun Shizhened slowly while controlling rate of addition during dropwise addition
Rock dropwise addition bottle, manual operation it is difficult to ensure that hemolysin rate of addition and be added dropwise bottle shaking speed, to cause hemolysin
The repeatability of titration experiments is bad；Since hemolysin titration is the middle experiment of anti-complement activity test experience, and in anticomplement
The accuracy of experimental result can be learnt by having to pass through final calculation result just during Activity determination, if hemolysin titration step
In the bad situation of duplicating property, will result in the detection again of anti-complement activity test experience, waste anti-complement activity inspection
The time for surveying experiment also wastes its testing cost.
Utility model content
For the deficiency in the presence of the prior art, the utility model provides a kind of anti-complement activity test experience with molten
Sanguinin titration outfit solves the problems, such as that repeatability is not high when manual operation hemolysin titration experiment in the prior art.
To achieve the above object, the utility model uses a kind of the following technical solution: anti-complement activity test experience
It is set between two support rods with hemolysin titration device including two support rods being vertically arranged fixed in support plate and support plate
Have through the fixed parallel buret installed of fixing piece and two support rods, buret outlet end be equipped with sequentially connected hose with
Closed-entry diversion pipe, wherein hose controls interval by control assembly and circulates, and draft tube outlets end, which is communicated with to subtract, swings pipe and water conservancy diversion
Pipe outlet fitting, which subtracts, swings inside pipe wall, subtracts and swings the drop tube that pipe is communicated with formed linker, and drop tube includes multistage vertical pipe,
It is connected between adjacent two vertical pipe by circular arc tube transitions, is drop tube outlet positioned at the vertical pipe lower end of last installation site
End, is equipped with titration bottle below drop tube outlet end, and titration bottle passes through the rotation of concussion Component driver and concussion.
The use principle of the utility model: hemolysin is placed in buret, is controlled between making hose by control assembly
It has a rest circulation, and then controls the hemolysin interval in buret and pass through hose, through the hemolysin of hose under the action of diversion pipe
Pipe is swung along subtracting to swing inside pipe wall and slide into subtract, in addition can make intermittently to enter to subtract to swing pipe with the drop tube for swinging pipe formation linker is subtracted
The lower outlet end of hemolysin interval from the vertical pipe of the last installation site of drop tube is low into titration bottle, and it is fixed to place in titration bottle
Orderly rotation, concussion and same orderly low hemolysin are mixed under the action of amount sheep erythrocyte suspension earthquake component.
Compared with the prior art, the utility model has the following beneficial effects: the control assembly energy of the utility model setting
Guarantee that hemolysin is added dropwise to the rate of addition in sheep erythrocyte suspension, concussion component can control sheep erythrocyte suspension in titration bottle
Rotation, oscillation frequency further improve the repeatability of hemolysin titration experiment, reduce because of anti-complement activity test experience result
Inaccuracy cause the number of anti-complement activity test experience detected again, while reduce anti-complement activity test experience when
Between with its testing cost.
Detailed description of the invention
FIG. 1 is a schematic structural view of the utility model；
Fig. 2 is the structure top view of the utility model control assembly.
In attached drawing: support plate 1, driving gear 3, vibrating frame 4, titration bottle 5, support rod 6, subtracts and swings pipe 7, the second motor 2
Two connectors 8, the first connector 10, determine block 11, are hose 12, sliding groove 13, dynamic stripping and slicing 14, T-bar 15, driven diversion pipe 9
Gear 16, mounting plate 18, first motor 19, drop tube 20, sucker 21, driving fluted disc 22, fixed plate 23, turns driving gear 17
Moving axis 24, oscillating bearing 25, obstacle block 26, countercheck rod 27, fixed column 28, mounting groove 29.
Specific embodiment
The utility model is described further with reference to the accompanying drawing.
As shown in FIG. 1 to FIG. 2, a kind of anti-complement activity test experience described in the utility model is filled with hemolysin titration
It sets, including two support rods 6 being vertically arranged fixed in support plate 1 and support plate 1, is equipped between two support rods 6 and passes through fixation
(fixing piece can be simple experiment and consolidated with iron clamp to buret part with the fixed parallel buret installed of two support rods 6
Fixed, the utility model purpose of design is mainly the exit velocity for controlling buret, so not drawing the structure of buret),
Buret outlet end is equipped with sequentially connected hose 12 and closed-entry diversion pipe 9, and wherein hose 12 passes through control assembly intermittent flow
Logical, 9 outlet end of diversion pipe, which is communicated with to subtract, swings pipe 7 and the outlet of diversion pipe 9 fitting subtracts and swings 7 inner wall of pipe, to guarantee the outlet of diversion pipe 9 patch
Conjunction, which subtracts, swings 7 inner wall of pipe, and diversion pipe 9 is connect by the first connector 10 with support rod 6, and the first connector 10 can be simple reality
Test room iron clamp.Subtract and swing the drop tube 20 that pipe 7 is communicated with formed linker, drop tube 20 includes multistage vertical pipe, adjacent
It is connected between two vertical pipes by circular arc tube transitions, is 20 outlet end of drop tube positioned at the vertical pipe lower end of last installation site,
The drop tube 20 of the utility model setting is formed using two vertical pipes and an arc tube, and drop tube 20 is swung pipe 7 and passed through with subtracting
Pipeline connection, subtracts and swings pipe 7 and be an integral structure with drop tube 20, subtract swing pipe 7 by simple second connector 8 such as iron clamp with support
Bar 6 is fixed, swings pipe 7 and drop tube 20 if being not provided with and subtracting, but directly low material is added cannot in titration bottle 5
Guarantee the material in buret be it is smooth enter in titration bottle 5, and subtracting for being arranged swings pipe 7 and drop tube 20 with regard to very good solution
This problem swings pipe 7 and drop tube 20 forms linker simultaneously because subtracting, can subtract the cross section for swinging pipe 7 by changing
The specific time for the material that area control is dripped from drop tube 20.Titration bottle 5, titration bottle are equipped with below 20 outlet end of drop tube
5 pass through the rotation of concussion Component driver and concussion.Hemolysin is placed in buret, is controlled by control assembly between making hose 12
Have a rest circulation, and then control the hemolysin interval in buret and pass through hose 12, by the hemolysin of hose 12 diversion pipe 9 work
Subtracted to swing 7 inner wall of pipe and slide into subtract with lower edge and swing pipe 7, and with subtract swing pipe 7 formed linker drop tube 20 can make interval into
The lower outlet end for entering to subtract the hemolysin for swinging pipe 7 interval from the vertical pipe of the last installation site of drop tube 20 is low into titration bottle 5,
Orderly rotation under the action of quantitative sheep erythrocyte suspension earthquake component, concussion are placed in titration bottle 5 with orderly low molten
Sanguinin is mixed.Since the utility model is anti-complement activity test experience hemolysin titration device, dripped with common soda acid
Fixed be not both hemolysin titration is not no titration end-point, cannot be detected with existing automatical potentiometric titrimeter on the market,
And potentiometric titrimeter cost is high and is not suitable for the titration of hemolysin in anti-complement activity test experience, and practical practical new
The hemolysin titration apparatus cost of type design is cheap and can be effectively controlled the dropwise addition speed that hemolysin is added dropwise in sheep erythrocyte suspension
Degree and the rotation of sheep erythrocyte suspension, oscillation frequency in titration bottle 5, improve the repeatability of hemolysin titration experiment.
Specifically as shown in Fig. 2, control assembly includes determining block 11, determines block 11 and a support rod 6 is fixedly mounted, it is fixed to keep off
Block 11 is provided with the arc-shaped mounting groove 29 of fitting 12 external wall cross-section of hose on the side of hose 12；Right angle setting slot 29 is long
It spends direction to be equipped with dynamic stripping and slicing 14 and move 14 one end of stripping and slicing in the arcuation of fitting 29 inner wall of mounting groove, dynamic stripping and slicing 14 is slidably mounted on cunning
In dynamic slot 13, sliding groove 13 is fixed by installation part and another support rod 6, and installation part includes being fixedly mounted with another support rod 6
Mounting plate 18, move stripping and slicing 14 by driving assembly driving move back and forth, move stripping and slicing 14 move back and forth interval by its arcuation end slide
It moves to making hose 12 intermittently circulate in mounting groove 29.Driving assembly include T-bar 15, driven gear 16 and with 16 phase of driven gear
The driving gear 17 mutually engaged, 15 vertical section of T-bar and dynamic stripping and slicing 14 are fixed, and 15 horizontal segment of T-bar is provided with along its horizontal segment length
The strip through-hole in direction is spent, 16 eccentric position of driven gear is equipped with fixed column 28, and fixed column 28 passes through strip through-hole and T-bar 15
Connection, driving gear 17 drive driven gear 16 to rotate by the driving rotation of first motor 19, the rotation of driving gear 17, driven tooth
16 rotation of wheel drives 15 vertical section of TT shape bar to move back and forth, and 15 vertical section of T-bar, which moves back and forth, drives dynamic stripping and slicing 14 to move back and forth.
Driven gear 16 is fixed with mounting plate 18 by bearing etc., and the shaft being arranged through mounting plate 18 is fixed on driving gear 17,
Shaft is fixedly mounted by the thirds connectors such as bearing and mounting plate 18, and shaft and first motor 19 are fixed.
Concussion component include for place the vibrating frame 4 of titration bottle 5, the fixed plate 23 being mounted between two support rods 6 with
Rotation axis 24, vibrating frame 4 is arranged outside is fixed with driving fluted disc 22, driving gear 3 driving of the driving fluted disc 22 by engagement, driving
Gear 3 is driven by the second motor 2 of coaxial arrangement, and the second motor 2 is mounted on 23 lower section of fixed plate, and the second motor 2 is by passing through
Connecting shaft and the driving gear 3 for fastening fixed board 23 are fixed, and connecting shaft is connect by bearing etc. with fixed plate 23.Bottom in vibrating frame 4
Face is equipped with multiple suckers 21, and 4 outer bottom of vibrating frame is equipped with countercheck rod 27, and vibrating frame 4 is mounted on 23 top of fixed plate, in fixed plate
It is located at below vibrating frame 4 on 23 and is additionally provided with multiple obstacle blocks 26,24 one end of rotation axis passes through oscillating bearing 25 and 4 outer bottom of vibrating frame
Face connection, 24 other end of rotation axis connect with fixed plate 23, the mainly inner ring of another spherical outside surface of oscillating bearing 25 and one
The outer ring of Internal Spherical Surface forms, and the outer ring of oscillating bearing 25 and rotation axis 24 are fixedly mounted, the inner ring and vibrating frame 4 of oscillating bearing 25
Outer bottom is fixed, and the utility model does not limit the installation site of connecting shaft Yu 4 outer bottom of vibrating frame, as long as being able to achieve vibrating frame
4 in the course of rotation, and the obstacle block 26 of the 27 energy Intermittent Contact setting of countercheck rod of 4 outer bottom of vibrating frame setting reaches concussion vibration
Countercheck rod 27 and 26 contact surface of obstacle block are preferably designed to that arc transition designs, obstacle block 26 by the purpose of dynamic frame 4
Be arranged to arcuation smooth transition block, the contact both facilitated with separate.3 turns of driving gear of second motor 2 driving coaxial arrangement
Dynamic, the driving rotation of gear 3 drives engagement driving fluted disc 22 to rotate, and the driving rotation of fluted disc 22 drives vibrating frame 4 to rotate, vibrating frame 4
Rotation makes 27 Intermittent Contact obstacle block 26 of countercheck rod rotate vibrating frame 4 and shakes, and vibrating frame 4 rotates and shakes drive vibrating frame
The titration bottle 5 being arranged in 4 is rotated and is shaken.
In view of used in the utility model buret, diversion pipe 9, subtract swing pipe 7, drop tube 20 is glassware,
Its thickness is not drawn in Figure of description.
In the explanation of the utility model, it should be noted that term " first ", " second ", " third ", " the 4th ", "upper",
"lower" etc. is merely for convenience of describing and understand, not to the limitation of technical characteristic application, does not also imply different technologies feature
Significance level.
Finally, it is stated that above embodiments are merely intended for describing the technical solutions of the present application, but not for limiting the present application, although ginseng
The utility model is described in detail according to preferred embodiment, those skilled in the art should understand that, it can be to this
The technical solution of utility model is modified or replaced equivalently, without departing from the objective and model of technical solutions of the utility model
It encloses, should all cover in the scope of the claims of the utility model.
Claims (4)
1. a kind of anti-complement activity test experience hemolysin titration device, it is characterised in that: including support plate (1) and support plate
(1) the two fixed support rods (6) being vertically arranged on are equipped between two support rods (6) and are consolidated by fixing piece and two support rods (6)
The buret for allocating row installation is equipped with sequentially connected hose (12) and closed-entry diversion pipe (9) in buret outlet end, wherein
Hose (12) controls interval by control assembly and circulates, and diversion pipe (9) outlet end, which is communicated with to subtract, swings pipe (7) and diversion pipe (9) out
Mouth fitting, which subtracts, swings pipe (7) inner wall, subtracts and swings the drop tube (20) that pipe (7) is communicated with formed linker, drop tube (20) includes
Multistage vertical pipe is connected by circular arc tube transitions between adjacent two vertical pipe, and the vertical pipe lower end positioned at last installation site is
Drop tube (20) outlet end is equipped with titration bottle (5) below drop tube (20) outlet end, and titration bottle (5) is driven by concussion component
Turn is dynamic and shakes.
2. a kind of anti-complement activity test experience hemolysin titration device according to claim 1, it is characterised in that: institute
Stating control assembly includes determining block (11), determines block (11) and a support rod (6) and is fixedly mounted, and determines block (11) close to hose
(12) the arc-shaped mounting groove (29) of fitting hose (12) external wall cross-section is provided on side；Right angle setting slot (29) length side
To dynamic stripping and slicing (14) and dynamic stripping and slicing (14) one end are equipped in the arcuation for being bonded mounting groove (29) inner wall, dynamic stripping and slicing (14) are slidably installed
In sliding groove (13), sliding groove (13) is fixed by installation part and another support rod (6), and dynamic stripping and slicing (14) pass through driving assembly
Driving moves back and forth, and dynamic stripping and slicing (14), which move back and forth interval and slide at its arcuation end in mounting groove (29), makes hose (12) interval
Circulation.
3. a kind of anti-complement activity test experience hemolysin titration device according to claim 2, it is characterised in that: institute
State driving assembly include T-bar (15), driven gear (16) and with driven gear (16) intermeshing driving gear (17), T
Shape bar (15) vertical section and dynamic stripping and slicing (14) are fixed, and the bar shaped that T-bar (15) horizontal segment is provided with along its horizontal section length direction is logical
Hole, driven gear (16) eccentric position are equipped with fixed column (28), and fixed column (28) passes through strip through-hole and connect with T-bar (15),
Driving gear (17) drives driven gear (16) rotation by first motor (19) driving rotation, driving gear (17) rotation, from
Moving gear (16) rotation drives T-bar (15) vertical section to move back and forth, and T-bar (15) vertical section, which moves back and forth, drives dynamic stripping and slicing
(14) it moves back and forth.
4. a kind of anti-complement activity test experience hemolysin titration device according to claim 1 or 3, feature exist
In: the concussion component includes the fixed plate for placing the vibrating frame of titration bottle (5) (4), being mounted between two support rods (6)
(23) with rotation axis (24), vibrating frame (4) is arranged outside is fixed with driving fluted disc (22), the driving that driving fluted disc (22) passes through engagement
Gear (3) driving, the second motor (2) driving that driving gear (3) passes through coaxial arrangement；Vibrating frame (4) inner bottom surface is equipped with multiple
Sucker (21), vibrating frame (4) outer bottom are equipped with countercheck rod (27), and vibrating frame (4) is mounted on above fixed plate (23), in fixed plate
(23) be located at below vibrating frame (4) on and be additionally provided with multiple obstacle blocks (26), rotation axis (24) one end by oscillating bearing (25) with
The connection of vibrating frame (4) outer bottom, rotation axis (24) other end are connect with fixed plate (23).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820829922.7U CN208239383U (en) | 2018-05-30 | 2018-05-30 | A kind of anti-complement activity test experience hemolysin titration device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820829922.7U CN208239383U (en) | 2018-05-30 | 2018-05-30 | A kind of anti-complement activity test experience hemolysin titration device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208239383U true CN208239383U (en) | 2018-12-14 |
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ID=64575240
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201820829922.7U Active CN208239383U (en) | 2018-05-30 | 2018-05-30 | A kind of anti-complement activity test experience hemolysin titration device |
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| CN (1) | CN208239383U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112284825A (en) * | 2020-10-19 | 2021-01-29 | 华兰生物工程重庆有限公司 | Volatile substance sealing and sampling device capable of being used independently |
-
2018
- 2018-05-30 CN CN201820829922.7U patent/CN208239383U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112284825A (en) * | 2020-10-19 | 2021-01-29 | 华兰生物工程重庆有限公司 | Volatile substance sealing and sampling device capable of being used independently |
| CN112284825B (en) * | 2020-10-19 | 2023-10-13 | 华兰生物工程重庆有限公司 | Volatile matter sealing sampling equipment capable of being used independently |
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