CN208194421U - A kind of fluid shearing force generating mechanism - Google Patents
A kind of fluid shearing force generating mechanism Download PDFInfo
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- CN208194421U CN208194421U CN201820375972.2U CN201820375972U CN208194421U CN 208194421 U CN208194421 U CN 208194421U CN 201820375972 U CN201820375972 U CN 201820375972U CN 208194421 U CN208194421 U CN 208194421U
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- branch flow
- flow passage
- fluid
- shearing force
- sprue
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Abstract
The utility model relates to micro-fluidic chip fields, the utility model discloses a kind of fluid shearing force generating mechanisms, including apparatus main body, sprue and at least two branch flow passages are provided on apparatus main body, the both ends of sprue are provided with fluid inlet and sprue fluid outlet, one end of branch flow passage is connected to sprue, and the other end is equipped with branch flow passage fluid outlet, is equipped with the valve that the sectional area passed through in the branch flow passage for fluid is adjusted in branch flow passage.The utility model utilizes the cooperation of sprue, branch flow passage and valve, and the dynamic change of hydrodynamic shear size and ratio can be realized in the case where not changing input fluid flow rate and apparatus structure.Meanwhile the utility model can greatly extend the ratio range of hydrodynamic shear in chopped-off head and final stage branch flow passage, and can be with the ratio at any point in coverage area, the utility model structure is simple, realization easy to spread.
Description
Technical field
The utility model relates to micro-fluidic chip fields, and it is big that hydrodynamic shear in runner may be implemented more particularly, to one kind
Range, the fluid shearing force generating mechanism of dynamic regulation and hydrodynamic shear generation method.
Background technique
Complicated vascular system is dispersed in human body, diameter is differed from several microns to several centimetres.Blood flow in vein and
The hydrodynamic shear formed in arteries respectively may be about 0.7-9dyn/cm2And 20-70dyn/cm2.In narrow arteries
Middle shearing force is sometimes more than 450dyn/cm2.The close phase of bioprocess of blood flow shearing force and a series of complex in human body
It closes.Grinding for this complicated shearing force environment Human Umbilical Vein Endothelial Cells function, cardiovascular disease and thrombus etc. is simulated in model in vitro
Study carefully and is of great significance.
Early in the eighties in last century, parallel-plate flow cavity and cone and plate viscometer shearing force device, just for studying shearing force
The influence of Human Umbilical Vein Endothelial Cells and thrombosis.With the development of micro-fluidic technologies, micro-fluidic chip, which can use, to be internally integrated
Micro-valve door or the syringe pump of outside generate continuous or pulsation hydrodynamic shear, for more accurate simulation blood
The shearing force formed is flowed, to further investigate the metamorphosis of endothelial cell, permeability, protein expression and across transendothelial electrical resistance
Deng.Also someone's formation logical using micro-fluidic chip simulation narrow blood vessel and thrombus.In addition, microfluid shearing force device can be with
It is used to assess the effect of resistance to compression drug.These researchs have greatly pushed endothelial cell basal research, thrombosis and treatment
Research, plays a significant role cardiovascular research and treatment.
The existing shearing force generating mechanism based on micro-fluidic chip mainly generates variation using actively and passively two ways
Hydrodynamic shear.Active mode is mainly by changing Inlet fluid flow velocity, to change cutting in all runners on entire chip
Shear force.Passive mode is the pipeline of pre-designed different length or width on chip, when liquid flows into different pipelines,
Its internal corresponding shearing force of generation.Above method is simply preferably gone, but has significant limitation, such as
(1) stream in the case where not changing input fluid velocity, in existing shearing force generating mechanism in each runner
The size of body shearing force be it is fixed, dynamic regulation can not be carried out.
(2) ratio of hydrodynamic shear is fixed and invariable (linear distribution) in different runners, sets not changing chip
Under the premise of meter, can not in each runner of dynamic regulation hydrodynamic shear ratio.
(3) it can not generate and cover hydrodynamic shear all in human blood circulatory system.Therefore, existing micro fluidic device is difficult
Complicated, large-scale fluid shearing force environment in accurate simulation human blood circulatory system.
Utility model content
For overcome the deficiencies in the prior art, the utility model proposes a kind of fluid shearing force generating mechanism and fluid shearings
Power generation method, for solving existing shearing force generating mechanism 1) all internal blood vessel hydrodynamic shears of human body can not be simulated
Size and 2) in the case where not changing input fluid velocity, can not in each runner of dynamic regulation the size of hydrodynamic shear with
The problem of ratio.
Solution adopted by the utility model to solve its technical problems is that:
A kind of fluid shearing force generating mechanism, including apparatus main body are provided with sprue and at least two on apparatus main body
Branch flow passage, the both ends of sprue are provided with fluid inlet and sprue fluid outlet, and one end of branch flow passage and sprue connect
Logical, the other end is equipped with branch flow passage fluid outlet, is equipped with to be adjusted in branch flow passage and passes through in the branch flow passage for fluid
The valve of sectional area.
Mode as a further improvement of the foregoing solution, valve include the flexible sheet for constituting the flow path wall of branch flow passage,
And to flexible sheet apply pressure so that its to runner inner recess pressurizing device.
Mode as a further improvement of the foregoing solution, pressurizing device press along unilateral direction to flexible sheet.
Mode as a further improvement of the foregoing solution, pressurizing device press along the circumferential of branch flow passage to flexible sheet.
Mode as a further improvement of the foregoing solution, valve include that the tool of the flow path wall of composition branch flow passage is magnetic
Flexible sheet, and apply magnetic field to flexible sheet to attract it to the magnetic devices of runner inner recess.
Mode as a further improvement of the foregoing solution, valve include the magnetic bead injected in branch flow passage, and to magnetic bead
Apply magnetic field so that the magnetic devices accumulated on its flow path wall in branch flow passage.
Mode as a further improvement of the foregoing solution, branch flow passage include being located at valve to branch flow passage and sprue to connect
Entrance area between logical, and set on valve to the shearing force adjustment region between branch flow passage fluid outlet.
Mode as a further improvement of the foregoing solution, several branch flow passages are set to the two sides or same of sprue
Side, and be parallel to each other.
Mode as a further improvement of the foregoing solution, each valve is separately adjustable, or is adjusted in synchronism.
The beneficial effects of the utility model are:
The utility model utilize sprue, branch flow passage and valve cooperation, can not change input fluid flow rate with
The dynamic change of hydrodynamic shear size and ratio is realized in the case where apparatus structure.Meanwhile the utility model can be great
The ratio range of hydrodynamic shear in chopped-off head and final stage branch flow passage is extended, and can be with the ratio at any point in coverage area
Value, the utility model structure is simple, realization easy to spread.
Detailed description of the invention
The utility model is further described with reference to the accompanying drawings and examples.
Fig. 1 is the front view of the utility model one embodiment；
Fig. 2 is the class specific resistance schematic diagram of the utility model sprue and branch flow passage；
Fig. 3 is the first embodiment waveform diagram of each branch flow passage shearing force ratio of the utility model；
Fig. 4 is the second embodiment waveform diagram of each branch flow passage shearing force ratio of the utility model；
Fig. 5 is the 3rd embodiment waveform diagram of each branch flow passage shearing force ratio of the utility model；
Fig. 6 is the fourth embodiment waveform diagram of each branch flow passage shearing force ratio of the utility model；
Fig. 7 is the schematic diagram of the utility model valve first embodiment；
Fig. 8 is the schematic diagram of the utility model valve second embodiment；
Fig. 9 is the schematic diagram of the utility model valve 3rd embodiment；
Figure 10 is the schematic diagram of the utility model valve fourth embodiment.
Specific embodiment
It is carried out below with reference to technical effect of the embodiment and attached drawing to the design of the utility model, specific structure and generation
Clear, complete description, to be completely understood by the purpose of this utility model, scheme and effect.It should be noted that not conflicting
In the case where, the features in the embodiments and the embodiments of the present application can be combined with each other.
It should be noted that unless otherwise specified, when a certain feature referred to as " fixation ", " connection " are in another feature,
It can directly fix, be connected to another feature, and can also fix, be connected to another feature indirectly.In addition, this
The descriptions such as up, down, left, right, before and after used in utility model are only relative to each composition portion of the utility model in attached drawing
For the mutual alignment relation divided.
In addition, unless otherwise defined, the technology of all technical and scientific terms used herein and the art
The normally understood meaning of personnel is identical.Term used in the description is intended merely to description specific embodiment herein, without
It is to limit the utility model.Term " and or " used herein includes appointing for one or more relevant listed items
The combination of meaning.
Referring to Fig.1, the front view of the utility model one embodiment is shown.As shown, hydrodynamic shear generates dress
It sets including not shown apparatus main body, is provided with sprue 100 and at least two branch flow passages 200, sprue on apparatus main body
100 both ends are provided with fluid inlet 101 and sprue fluid outlet 102, and one end of branch flow passage 200 and sprue 100 connect
Logical, the other end is equipped with branch flow passage fluid outlet 201.Preferably, branch flow passage 200 is set to sprue 100 in the present embodiment
The same side and be parallel to each other.
Wherein, the utility model is provided with to be adjusted in the branch flow passage 200 in each branch flow passage 200 and lead to for fluid
Branch flow passage 200 is divided into two regions by the valve 300 for the sectional area crossed, valve 300, respectively be located at valve 300 to point
Entrance area 202 between 100 connectivity part of branch flow passage 200 and sprue, and valve 300 is set to branch flow passage fluid outlet
Shearing force adjustment region 203 between 201.By independently or synchronously controlling each valve 300, adjustable each valve 300
The sectional area of the branch flow passage 200 at place, and then the shearing force of each branch flow passage 200 is dynamically adjusted, and greatly extension shearing
The variation range of power, wherein the realization principle of the utility model is as follows:
Referring to Fig. 2, the class specific resistance schematic diagram of the utility model sprue and branch flow passage is shown.As shown, main
Runner approximate can regard analogous circuit shown in figure as with branch flow passage, wherein analogize to the flow resistance of runner in electronic circuit
Resistance, RmIndicate the sprue flow resistance between 100 junction of each branch flow passage 200 and sprue, RsIndicate entrance area
202 flow resistance, RvIndicate the flow resistance of valve 300, RcIndicate the flow resistance of shearing force adjustment region 203.
Wherein, for non-valve region, cross section of fluid channel is rectangle (h < w), therefore flow resistance Rm、RsAnd RcIt can be by formula:
Calculating acquires.Wherein μ represents the dynamic viscosity of fluid, and L represents flow channel length, and w represents width of flow path, and h represents stream
Road height.Based on above-mentioned, it is known that in the case that fluid dynamic viscosity remains unchanged, the not changed non-valve of area of section
The flow resistance in region is definite value.
For valve region, the flow resistance R of valve 300vIt is then determined by valve deformation extent, for there is several branch flow passages
Fluid channel (assuming that score value runner sum is n) can calculate outflow Q from the last one crotch of runnern.From the bifurcated stream
Liquid out is divided into two shuntings, and a flow direction outlet, another flows to last branch flow passage.It is flowed to from last crotch
The flow resistance of the runner of outlet meets:
R (n)=Rm
And flow and flow resistance are inversely, so rate of discharge (qn) and the last one branch flow passage flow (Qn) between
Relationship meet:
Wherein:
Rb=Rs+Rv+Rc
Then, it discusses in penultimate crotch.The inlet flow rate of a bifurcation mouth last can regard inverse as
Rate of discharge (the q of second bifurcation mouthn-1), the flow resistance of all runners meets after penultimate bifurcation mouth:
The assignment of traffic of penultimate bifurcation mouth meets again:
And so on, using iteration, can be obtained for i-th (1≤i≤n) a bifurcation mouth:
Wherein, due to
R (n)=Rm
Also, flow (the Q of i-th of branch flow passage entrancei) meet:
Therefore the flow ratio in each branch flow passage can be found out by above-mentioned formula, i.e., the shearing force in the utility model is adjusted
Flow ratio in region 203.Further according to the shearing force formula in square pipe:
The shearing force ratio in the region of variation of each branch flow passage can be found out.Wherein, μ represents fluid dynamic viscosity, Q
The volume flow of fluid in runner is represented, w represents the width of runner, and h represents the height of runner.To sum up, as shown from the above formula,
The flow resistance R of the valve of each runner need to only be changedv, the variation of discharge relation in each branch flow passage can be realized, and then generate
The dynamic adjustment of shearing force size also may be implemented even if the flow velocity of input fluid is constant in the variation of shearing force relationship.
The utility model does not limit the quantity of branch flow passage 200, and quantity is adjusted according to the adjustable range of shearing force, branch
The quantity of runner 200 is more, and variation range is bigger, referring to table 1, it is shown that the shearing stress maximum changing range of theoretical calculation with point
The relationship of branch flow passage quantity:
The hydrodynamic shear ratio in chopped-off head and final stage runner when total branched bottom number changes of table 1
As can be seen from the above table, when being equipped with 8 branch flow passages, by control valve, in chopped-off head and final stage branch flow passage
The ratio of hydrodynamic shear can achieve 18509:1, and since the deformation of valve region flow resistance is continuously that flow resistance can also
Realize consecutive variations, i.e., the utility model can in coverage area any point shearing stress value ratio.
When changing the size of cross-sectional area of some branch flow passage 200, shearing force in all branch flow passages 200 it is big
Small and ratio all changes.By accurately controlling the closure degree of the valve 300 in each branch flow passage 200, may be implemented
Make switching at runtime of the hydrodynamic shear numeric distribution between the rule such as linear, index and sine in each branch flow passage 200.
Referring to table 2, by taking diaphragm type valve as an example, the combination (setting first of the deformation of membrane of each branch flow passage is shown
Deformation of membrane in branch flow passage is a):
Each branch flow passage valve deflection needed for table 2 realizes specific shear forces distribution
When deflection combination listed in table is respectively adopted in each branch flow passage, hydrodynamic shear in each branch flow passage 200
Numerical value according to as shown in Fig. 3 to Fig. 6 distribution.
The sectional area that valve in the utility model is used to adjust branch flow passage 200 is shown respectively referring to Fig. 7 to Figure 10
The schematic diagram of valve difference embodiment in the utility model.Specifically, as shown in fig. 7, valve 300 includes constituting branch flow passage
The flexible sheet 301 of 200 flow path wall, and apply pressure so that its pressurization to runner inner recess to flexible sheet 301
Device (not shown), after pressurizing device applies pressure, 200 sectional area of branch flow passage reduces, after pressure is eliminated, flexible sheet
301 restore under the action of own resilient, and 200 sectional area of branch flow passage restores therewith.
Pressurizing device can use the prior art, such as actuating device of atmospheric pressure, fluid pressure drive device, and the utility model is to this
It is not construed as limiting.
The pressure mode of the utility model also without limitation, such as can with as shown in fig. 7, pressurizing device to flexible sheet
301 are unidirectionally pressed, and can also carry out multidirectional pressure to flexible sheet 302 along the circumferential of branch flow passage 200 as shown in Figure 8.
As shown in figure 9, valve 300 includes the magnetic flexible sheet 303 of tool for constituting the flow path wall of branch flow passage 200,
And apply magnetic field to flexible sheet 303 to attract its magnetic devices 401 to runner inner recess.Herein referred has magnetic
Property flexible sheet, either flexible sheet 303 itself have magnetism, be also possible to additionally fix on flexible sheet 303
Has magnetic component.It, can also be in addition, herein referred magnetism both can be understood as being able to carry out actively adsorbing other component
It is interpreted as to be adsorbed by other component.
As shown in Figure 10, valve 300 include injection branch flow passage in magnetic bead 304, and to magnetic bead 304 apply magnetic field with
Make the magnetic devices 402 accumulated on its flow path wall in branch flow passage.With the enhancing and decrease in magnetic field, it is adsorbed on flow path wall
On magnetic bead 304 also can increase accordingly and reduce.
Magnetic part in the present embodiment is preferably electromagnet, in order to be able to dynamically adjust magnetic size.
In addition to the above embodiments, the utility model can also use other known valve mechanism, practical new to this
Type is not construed as limiting.
The invention also discloses a kind of hydrodynamic shear generation methods, include the following steps,
S10 setting has the sprue of fluid inlet and sprue fluid outlet, and is arranged and is connected at least with sprue
Two branch flow passages, branch flow passage have branch flow passage fluid outlet.
S20 be arranged in each branch flow passage be adjusted a certain section of the branch flow passage sectional area valve, valve herein
It can be using the valve mechanism in above-described embodiment.
S30 injects fluid into sprue by fluid inlet, and by adjusting each valve, to adjust each branch flow passage
The size and ratio of interior shearing force.
Further, after above-mentioned each valve regulated finishes, can also by adjust sprue in fluid flow rate, with
The size of shearing force is adjusted in the case that shearing force ratio in each branch flow passage remains unchanged.
It is illustrating for progress to be implemented to the preferable of the utility model, but the invention is not limited to the reality above
Example is applied, those skilled in the art can also make various equivalent variations without departing from the spirit of the present invention
Or replacement, these equivalent deformations or replacement are all included in the scope defined by the claims of the present application.
Claims (9)
1. a kind of fluid shearing force generating mechanism, which is characterized in that including apparatus main body, be provided with mainstream in described device main body
Road and at least two branch flow passages, the both ends of the sprue are provided with fluid inlet and sprue fluid outlet, the branch
One end of runner is connected to the sprue, and the other end is equipped with branch flow passage fluid outlet, is equipped in the branch flow passage adjustable
Save the valve of the sectional area passed through in the branch flow passage for fluid.
2. fluid shearing force generating mechanism according to claim 1, which is characterized in that the valve includes constituting described point
The flexible sheet of the flow path wall of branch flow passage, and apply pressure so that its pressurization to runner inner recess to the flexible sheet
Device.
3. fluid shearing force generating mechanism according to claim 2, which is characterized in that the pressurizing device is along unilateral direction
It presses to the flexible sheet.
4. fluid shearing force generating mechanism according to claim 2, which is characterized in that the pressurizing device is along the branch
The circumferential of runner presses to the flexible sheet.
5. fluid shearing force generating mechanism according to claim 1, which is characterized in that the valve includes constituting described point
The magnetic flexible sheet of the tool of the flow path wall of branch flow passage, and apply magnetic field to the flexible sheet to attract it into runner
The magnetic devices of portion's recess.
6. fluid shearing force generating mechanism according to claim 1, which is characterized in that the valve includes described point of injection
Magnetic bead in branch flow passage, and apply magnetic field so that its magnetic for accumulating on the flow path wall in the branch flow passage to the magnetic bead
Property device.
7. fluid shearing force generating mechanism according to claim 1, which is characterized in that the branch flow passage includes being located at institute
Valve is stated to the entrance area between the branch flow passage and the sprue connectivity part, and is set to the valve to described point
Shearing force adjustment region between branch flow passage fluid outlet.
8. fluid shearing force generating mechanism according to claim 1, which is characterized in that several branch flow passages are set to
The two sides or the same side of the sprue, and be parallel to each other.
9. fluid shearing force generating mechanism according to claim 1, which is characterized in that each valve is separately adjustable, or
Person is adjusted in synchronism.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820375972.2U CN208194421U (en) | 2018-03-20 | 2018-03-20 | A kind of fluid shearing force generating mechanism |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820375972.2U CN208194421U (en) | 2018-03-20 | 2018-03-20 | A kind of fluid shearing force generating mechanism |
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| Publication Number | Publication Date |
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| CN208194421U true CN208194421U (en) | 2018-12-07 |
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| CN201820375972.2U Expired - Fee Related CN208194421U (en) | 2018-03-20 | 2018-03-20 | A kind of fluid shearing force generating mechanism |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108339580A (en) * | 2018-03-20 | 2018-07-31 | 哈尔滨工业大学深圳研究生院 | A kind of fluid shearing force generating mechanism and hydrodynamic shear generation method |
-
2018
- 2018-03-20 CN CN201820375972.2U patent/CN208194421U/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108339580A (en) * | 2018-03-20 | 2018-07-31 | 哈尔滨工业大学深圳研究生院 | A kind of fluid shearing force generating mechanism and hydrodynamic shear generation method |
| CN108339580B (en) * | 2018-03-20 | 2020-01-14 | 哈尔滨工业大学深圳研究生院 | Fluid shear force generation device and fluid shear force generation method |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CB03 | Change of inventor or designer information | ||
| CB03 | Change of inventor or designer information |
Inventor after: Chen Huaying Inventor after: Chen Chang Inventor after: Zhu Yonggang Inventor after: Yu Zhihang Inventor before: Chen Huaying |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20181207 Termination date: 20200320 |