CN208114678U - Vertebral artery stent - Google Patents

Abstract

The utility model provides a kind of vertebral artery stent, and the vertebral artery stent includes multiple first unit ring structures, multiple second unit ring structures and multiple connection structures, wherein：Multiple first unit ring structures and multiple second unit ring structure axial alignments；The connection structure connects multiple first unit ring structures and multiple second unit ring structures, and multiple first unit ring structures and multiple second unit ring structures is made to form a net column structure；The mesh area formed between the adjacent first unit ring structure is less than the mesh area formed between the adjacent second unit ring structure；Each connection structure includes a straight-bar connecting rod arranged along the net post shape structure axial direction, and " S " the type structure being connected with the straight-bar connecting rod.The utility model solves the problems, such as that the existing bracket for vertebral artery fails to have both high radial support force, flexibility and fatigue durability.

Description

Vertebral artery stent

Technical field

The utility model relates to the field of medical instrument technology, in particular to a kind of vertebral artery stent.

Background technique

The atherosclerosis that Vertebro-basilar System occurs is one of the main reason for leading to rear circulation stroke about five / mono- rear circulation stroke occurs in Extracranial Segment of Vertebral Artery.There are many therapeutic scheme is available for symptomatic vertebral artery： Be applied alone medicament for resisting platelet aggregation carry out secondary prevention, year stroke incidence still be up to 15%；Warfarin treatment and aspirin Therapeutic effect is suitable, but the risk of bleeding greatly increases；Surgical operation art formula is complicated, and risk is high, carries out extensively also clinical It is limited.Vertebral artery narrowing is little in medication effect, and surgical risk is excessively high, and limitation is excessive, endovascular treatment by Gradually become trend.

Whole process in vertebral-basilar artery can occur for atherosclerotic stenosis, but wherein be moved with vertebral artery under clavicle Initial part at arteries and veins sending is most commonly seen.In addition, the variation of vertebral artery initial part is more, often there is side vertebral artery advantage, and Other side vertebral artery is more very thin from the initial segment to intracranial segment, or even nearly 1~2 times of the caliber difference of left and right vertebral artery occurs Or above situation.Such case after also leading to thinner vascellum laterale Stent Implantation is easier to that restenosis occurs.From histology spy Sign analysis, the vascular wall of vertebral artery initial part contain a large amount of smooth muscles for being rich in elastin laminin, have biggish bounce to bracket. Vertebral artery itself is almost issued at right angle from subclavian artery, and distal end is relatively movable, and proximal end is then fixed by skeletal thorax, and with chest Wide respiratory activity, these all inevitably cause the fatigue of bracket.Therefore, vertebral artery stent needs higher radial support Power, while also needing the fatigue performance and lesion handling capacity of higher level.

Be not exclusively used in the support product for the treatment of vertebral artery narrowing lesion both at home and abroad at present, clinically mostly by intracranial stent or Renal artery stent over adaptation disease uses, but effect is still undesirable.The intracranial stent clinically used, in order to adapt to intracranial vessel Demand is just weak in vertebral artery narrowing treatment, this controls vertebral artery narrowing although flexibility is preferable in terms of support force Commonplace the case where stent fatigue in treatment, treatment will be extremely difficult after fatigue fracture occurs for bracket.Renal artery stenting vertebra Arteriarctia, although support force is relatively suitble to, flexibility is poor, and anatomical structure and the physiology that cannot be well adapted for vertebral artery are special Sign.

In short, the bracket or bracket radial support power in the prior art for vertebral artery is insufficient, rebound, which easily occurs, to be caused Restenosis；Or flexibility is insufficient, cannot be well adapted for vascular morphology；Or fatigue durability is poor, bracket easily causes Long-Term Safety Problem.

The vertebral artery stent that therefore, it is necessary to design a kind of support force, fatigue durability and flexibility are taken into account.

Utility model content

One of the purpose of this utility model is to provide a kind of vertebral artery stent, to solve the existing branch for vertebral artery Frame fails the problem of having both high radial support force, fatigue durability and flexibility.

The another object of the utility model is, also improves the fatigue durability of vertebral artery stent.

In order to solve the above technical problems, the utility model provides a kind of vertebral artery stent, the vertebral artery stent includes more A connected first unit ring structure, multiple second unit ring structures and connection structure, wherein：

Multiple first unit ring structures and multiple second unit ring structure axial alignments；

The connection structure connects multiple first unit ring structures and multiple second unit ring structures, makes multiple The first unit ring structure and multiple second unit ring structures form a net column structure；

The mesh area formed between the adjacent first unit ring structure is less than the adjacent second unit ring knot The mesh area formed between structure；

Each connection structure includes a straight-bar connecting rod arranged along the net post shape structure axial direction, Yi Jiyu Connected " S " the type structure of the straight-bar connecting rod.

Optionally, in the vertebral artery stent, the first unit ring structure is located in the net column structure Between, the second unit ring structure is located at the both ends of the net column structure.

Optionally, in the vertebral artery stent, the first unit ring structure include multiple first net order members and Multiple second net order members, wherein：

The first net order member is first " V " character form structure, and the second net order member is " W " character form structure, described First net order member and the second net order member are spaced apart from each other arrangement along the circumferential direction of the net column structure, and are sequentially connected.

Optionally, in the vertebral artery stent, each first net order member includes first loop end frame With two the first straight-bar structures, wherein：

First loop end frame pass through respectively two First Transition structures be connected to two the first straight-bar structures it Between, so that two the first straight-bar structures is formed first " V " character form structure.

Optionally, in the vertebral artery stent, each second net order member include second loop end frame, Two third loop end frames and four the second straight-bar structures, wherein：

Each third loop end frame passes through two the second transition structures respectively and is connected to two the second straight-bar knots Between structure, two the second straight-bar structures is made to form second " V " character form structure；

Two third loop end frames are separately connected four the second straight-bar structures, form two second " V " Character form structure；

Second loop end frame is separately connected two described second " V " character form structures, makes two described second " V " fonts Structure forms described " W " character form structure.

Optionally, in the vertebral artery stent, lead between the first net order member and the second net order member The 4th loop end frame is crossed to be connected.

Optionally, in the vertebral artery stent, the second unit ring structure include multiple 5th loop end frames and Multiple third straight-bar structures, wherein：

5th loop end frame pass through respectively two third transition structures be connected to two third straight-bar structures it Between, so that two third straight-bar structures is formed third " V " character form structure, multiple " V " character form structures are along the net post shape The circumferential array of structure, and be sequentially connected by the 6th loop end frame.

Optionally, in the vertebral artery stent, the length of the first straight-bar structure and third straight-bar structure is greater than The length of the length of the second straight-bar structure, the second straight-bar structure and the first straight-bar structure or third straight-bar structure Ratio is between 0.65~0.75.

Optionally, in the vertebral artery stent, first loop end frame, the third loop end frame, described Four loop end frames, the 5th loop end frame and the 6th loop end frame are semi-circular ring, and second loop end frame is in two The shape of a one side of semi-circular ring connection, the first straight-bar structure, the second straight-bar structure and the third straight-bar knot Structure is that section is rectangular column.

Optionally, in the vertebral artery stent, first loop end frame, the third loop end frame, described The ring width of four loop end frames, the 5th loop end frame and the 6th loop end frame is less than the first straight-bar structure, described The width of second straight-bar structure and the third straight-bar structure, the ring width of first loop end frame and the first straight-bar knot Structure, the second straight-bar structure or the third straight-bar structure width ratio be 0.85~0.95 between.

Optionally, in the vertebral artery stent, the ring width of second loop end frame is less than the first straight-bar knot The width of structure and the second straight-bar structure and the third straight-bar structure, the ring width of second loop end frame and described first The ratio of the width of straight-bar structure, the second straight-bar structure or the third straight-bar structure is between 0.85~0.95.

Optionally, in the vertebral artery stent, the connection structure includes multiple first connection structures and multiple Two connection structures, wherein：

It is connected between the first unit ring structure of adjacent two by first connection structure；

It is connected between the second unit ring structure of adjacent two by second connection structure；

Pass through first connection structure between the adjacent first unit ring structure and the second unit ring structure And/or the second connection structure connection.

Optionally, in the vertebral artery stent, first connection structure one end connects the 4th loop end frame Or the 6th loop end frame, the other end of first connection structure connect second loop end frame；Second connection One end of structure connects the 4th loop end frame or the 6th loop end frame, and the other end connects the 5th loop end frame.

Optionally, in the vertebral artery stent, first connection structure includes " S " the type structure and described straight Bar connecting rod, wherein：

It is straight far from described second that described type structure one end " S " connects the 4th loop end frame or the 6th loop end frame The center of rod structure or the third straight-bar structure side, the other end connect the straight-bar connecting rod, and the straight-bar connecting rod connects Second loop end frame is connect close to the center of the second straight-bar structure side；

The straight-bar connecting rod is parallel to the axial direction of the net column structure.

Optionally, in the vertebral artery stent, second connection structure is " n " character form structure, " n " font Structure one end connects the 4th loop end frame or the 6th loop end frame far from the second straight-bar structure or the third The center of straight-bar structure side, the other end connect center of the 5th loop end frame far from the third straight-bar structure side.

Optionally, in the vertebral artery stent, there is medication coat, the medication coat in the vertebral artery stent Coated in the first straight-bar structure and/or the second straight-bar structure and/or the First Transition structure and/or described second On the outer surface of transition structure and/or the third transition structure.

Optionally, in the vertebral artery stent, the first straight-bar structure and/or the second straight-bar structure and/ Or third straight-bar structure and/or the First Transition structure and/or second transition structure and/or the third transition structure Outer surface there is groove, the groove carries the medication coat.

Optionally, in the vertebral artery stent, each first unit ring structure or the second unit ring knot The length summation of the groove on structure accounts for the first unit ring structure or the second unit ring structure overall length where it The 60%-75% of degree, the width of the groove account for the first straight-bar structure where it and the second straight-bar structure and/or Third straight-bar structure and/or the First Transition structure and/or second transition structure and/or the third transition structure The 45%-60% of width, the depth of the groove account for the first straight-bar structure where it and the second straight-bar structure and/ Or third straight-bar structure and/or the First Transition structure and/or second transition structure and/or the third transition structure Thickness 15%-30%.

In a kind of vertebral artery stent provided by the utility model, pass through shape between the adjacent first unit ring structure At mesh area be less than the mesh area that is formed between the adjacent second unit ring structure, in contrast in the prior art only There is the technical solution of the big mesh of second unit ring structure, effectively reduce the mesh area of vertebral artery stent part-structure, Increase the radial support power to lesion patch；In addition, the connection structure includes " S " type structure, bracket is made to be easy to longitudinal curved Song improves the flexibility of bracket.It when transfer gantry passes through curved blood vessel, crosses lesion ability and greatly improves, and when bracket is planted After entering in vivo, it can be well adapted for vascular morphology, be bonded blood vessel.In addition, straight-bar connection rod structure can make described " S " type knot The direction of structure is fixed, and can be deeper into being attached inside first unit ring structure or second unit ring structure.This is practical new The vertebral artery stent that type provides, overcomes the deficiency of existing vertebral artery stent, meets the physiological characteristic of vertebral artery, make vertebral artery branch The flexibility (safety) and high radial support force (validity) of frame are taken into account on a more sophisticated level.

Detailed description of the invention

Fig. 1 is that the utility model vertebral artery stent is whole along axially expanded planar structure schematic diagram；

Fig. 2 is first unit ring structure schematic diagram in the utility model vertebral artery stent；

Fig. 3 is first " V " character form structure schematic diagram in the utility model vertebral artery stent；

Fig. 4 is " W " character form structure schematic diagram of the second " V " character form structure composition in the utility model vertebral artery stent；

Fig. 5 is second unit ring structure and the second attachment structure schematic diagram in the utility model vertebral artery stent；

Fig. 6 is the first attachment structure schematic diagram in the utility model vertebral artery stent；

As shown in the figure：1- first unit ring structure；The first net of 11- order member/first " V " character form structure；The first ring of 111- End structure；112- the first straight-bar structure；113- First Transition structure；The second net of 12- order member/" W " character form structure；121- second Loop end frame；122- third loop end frame；123- the second straight-bar structure；The second transition structure of 124-；The 5th transition structure of 125-； The 4th loop end frame of 13-；The 4th transition structure of 14-；2- second unit ring structure；The 5th loop end frame of 21-；22- third straight-bar Structure；23- third transition structure；The 6th loop end frame of 24-；The 6th transition structure of 25-；3- connection structure；The connection of 31- first knot Structure；311- " S " type structure；312- straight-bar connecting rod；The second connection structure of 32-；4- medication coat or groove.

Specific embodiment

Below in conjunction with the drawings and specific embodiments to the utility model proposes a kind of vertebral artery stent make further it is detailed Explanation.According to following explanation and claims, will be become apparent from feature the advantages of the utility model.It should be noted that attached drawing It is all made of very simplified form and uses non-accurate ratio, only to facilitate, lucidly aid in illustrating the utility model The purpose of embodiment.

The core concept of the utility model is to provide a kind of vertebral artery stent, to solve the existing branch for vertebral artery Frame fails the problem of having both high radial support force, flexibility and fatigue durability.

To realize above-mentioned thought, the utility model provides a kind of vertebral artery stent, and the vertebral artery stent includes multiple First unit ring structure, multiple second unit ring structures and multiple connection structures, wherein：Multiple first unit ring structures and Multiple second unit ring structure axial alignments；The connection structure connects multiple first unit ring structures and multiple institutes Second unit ring structure is stated, multiple first unit ring structures and multiple second unit ring structures is made to form a net post shape Structure；The mesh area formed between the adjacent first unit ring structure be less than the adjacent second unit ring structure it Between the mesh area that is formed；Each connection structure includes a straight-bar connection arranged along the net post shape structure axial direction Bar, and " S " the type structure being connected with the straight-bar connecting rod.

Fig. 1 is the utility model vertebral artery stent deployed configuration schematic diagram.Present embodiment provides a kind of vertebral artery stent, As shown in Figure 1, the vertebral artery stent includes multiple first unit ring structures 1, multiple second unit ring structures 2 and multiple connections Structure 3, wherein：Multiple first unit ring structures 1 and multiple 2 axial alignments of second unit ring structure；The connection Structure 3 connects multiple first unit ring structures 1 and multiple second unit ring structures 2, makes multiple first units Ring structure 1 and multiple second unit ring structures 2 form a net column structure；The adjacent first unit ring structure 1 it Between the mesh area that is formed be less than the mesh area formed between the adjacent second unit ring structure 2；Each connection Structure 3 include one along the net post shape structure axial direction arrangement straight-bar connecting rod 312, and with the straight-bar connecting rod phase " S " type structure 311 even.

Applicants have found that requirement of the position for radial support power is higher compared with its both ends among vertebral artery stent, therefore And in preferred embodiment, the first unit ring structure 1 is located at the centre of the net column structure, the second unit ring structure 2 Positioned at the both ends of the net column structure.Further, the quantity of the second unit ring structure 2 at net column structure both ends can It, can also be unequal with equal.For example, as shown in Figure 1, the vertebral artery stent includes four first unit ring structures 1 and three A second unit ring structure 2, four first unit ring structures 1 are located at the centre of the net column structure, four first unit rings The side of structure 1 is distributed two second unit ring structures 2, and the other side of four first unit ring structures 1 is distributed one second list Ring structure 2.It should be understood that the distribution mode of the first unit ring structure 1 and second unit ring structure 2 be not limited to it is above-mentioned Citing, such as the two can also be alternately distributed.

In the vertebral artery stent, as shown in Fig. 2, the first unit ring structure 1 includes multiple first net orders Member 11 and multiple second net order members 12, wherein：The first net order member 11 is first " V " character form structure, second net Order member 12 is " W " character form structure, and the first net order member 11 and the second net order member 12 are along the net column structure Circumferential direction be spaced apart from each other arrangement, and be sequentially connected.It should be appreciated that " V " character form structure mentioned herein is also possible to substantially " v " shaped structure, similarly, " W " character form structure mentioned herein are also possible to the structure substantially in " W " font.

Specifically, as shown in Fig. 2, each first net order member 11 includes first loop end frame 111 and two First straight-bar structure 112.Wherein, as shown in figure 3, first loop end frame 111 passes through two First Transition structures 113 respectively It is connected between two the first straight-bar structures 112, that is, one end of first loop end frame 111 passes through a transition knot Structure 113 connects a first straight-bar structure 112, and the other end of first loop end frame 111 passes through another transition structure 113 Another the first straight-bar structure 112 is connected, so that two the first straight-bar structures 112 be made to form described first " V " font knot Structure.As shown in Fig. 2, each second net order member 12 includes 121, two third loop end frames of second loop end frame 122 and four the second straight-bar structures 123, wherein：As shown in Figure 2 and Figure 4, each third loop end frame 122 passes through respectively Two second transition structures 124 are connected between two the second straight-bar structures 123, that is, the third loop end frame 122 one end connects a second straight-bar structure 123 by second transition structure 124, the third loop end frame 122 The other end connects another the second straight-bar structure 123 by another second transition structure 124, makes two the second straight-bar knots Structure 123 forms described second " V " character form structure；Two third loop end frames 122 are separately connected four second straight-bars Structure 123 forms two described second " V " character form structures；Second loop end frame 121 is separately connected two described second " V " character form structure makes two described second " V " character form structures form described " W " character form structure, second loop end frame 121 One end connects one second " V " character form structure by the 5th transition structure 125, and the other end passes through the 5th transition structure 125 Another second " V " character form structure is connected, to form " W " character form structure.The first net order member 11 and second net It is connected between order member 12 by the 4th loop end frame 13,13 one end of the 4th loop end frame is connected by the 4th transition structure 14 The first net order member 11 is connect, the other end connects the second net order member 12 by the 4th transition structure 14.

In addition, in the vertebral artery stent, as described in figures 1 and 5, the second unit ring structure 2 includes multiple the Five loop end frames 21 and multiple third straight-bar structures 22, wherein：5th loop end frame 21 passes through two third transition respectively Structure 23 is connected between two third straight-bar structures 22, and two third straight-bar structures 22 is made to form third " V " word Shape structure, multiple third " V " character form structures along the net column structure circumferential array, and by the 6th ring end tie Structure 24 is sequentially connected, and one end of the 6th loop end frame connects third " V " character form structure by the 6th transition structure 25, another End connects another third " V " character form structure by the 6th transition structure 25.Further, two adjacent third " V " fonts Structure is connected from beginning to end by the 6th loop end frame 24.

Further, in the vertebral artery stent, the length and third straight-bar structure of the first straight-bar structure 112 22 length is greater than the length of the second straight-bar structure 123, it is preferred that the length and third straight-bar of the first straight-bar structure 112 The equal length of structure 22, when making vertebral artery stent, the straight-bar structure of identical size can make technique simpler.Described The lenth ratio of two straight-bar structures 123 and the first straight-bar structure 112 or third straight-bar structure 22 be 0.65~0.75 between, Since the connection between first unit ring structure is the center by the second net order member 12 where the second straight-bar structure of connection Connection, therefore, the shortening of the second straight-bar structure length can reduce the size of connection structure between first unit ring structure, further Reduce the mesh area between first unit ring structure, improves support force.As figures 2-6, first loop end frame 111, third loop end frame 122, the 4th loop end frame 13, the 5th loop end frame 21, the 6th loop end frame 24 are semi-circular ring, Second loop end frame 121 is in the shape of two one sides of semi-circular ring connection, the first straight-bar structure 112, described the Two straight-bar structures 123 and third straight-bar structure 22 are the column of section squarish.First loop end frame 111, second Loop end frame 121, third loop end frame 122, the 4th loop end frame 13, the 5th loop end frame 21, the 6th loop end frame 24 ring Width is equal, is H1, and H1 is less than the first straight-bar structure 112, the second straight-bar structure 123 and third straight-bar structure 22 Width, it is preferred that the width phase of the first straight-bar structure 112, the second straight-bar structure 123 and third straight-bar structure 22 Together, the ratio of H1 and the width of the first straight-bar structure 112, the second straight-bar structure 123 and third straight-bar structure 22 is 0.85 Between~0.95.In order to reduce the size after bracket pressure is held, and guarantee enough medication coat amounts, the first loop end frame 111, the Two loop end frames 121, third loop end frame 122, the 4th loop end frame 13, the 5th loop end frame 21, the 6th loop end frame 24 Width H1 size is smaller, and the first straight-bar structure 112, the second straight-bar structure 123 and third straight-bar 22 width of structure are larger, The size for being loaded with the groove of medication coat can be increased.As shown in Fig. 5~6, in the vertebral artery stent, the connection structure Including multiple first connection structures 31 and multiple second connection structures 32, wherein：Between two adjacent first unit ring structures 1 It can be connected by first connection structure 31；The second connection can be passed through between two adjacent second unit ring structures 2 Structure 32 connects；It can be between adjacent first unit ring structure 1 and second unit ring structure 2 and all tied by the first connection Structure 31 connects, and is also possible to all connect by the second connection structure 32, can also be that a part passes through the first connection structure 31 Connection, another part are connected by the two the second connection structures 32.Wherein, when the second loop end frame 121 is close to the second straight-bar knot When the side of structure 123 is towards second unit ring structure 2, the second unit ring structure 2 and 121 place of the second loop end frame First unit ring structure 1 (i.e. as shown in fig. 1, the first unit ring structure of left end) between connected by the first connection structure 31 It connects, is otherwise connected by the second connection structure 32.

Specifically, continuing to refer to figure 1, the first connection structure being connected between two adjacent first unit ring structures 1 31, one end connects between first " V " character form structure and second " V " character form structure, " W " font knot described in other end connection Structure, the first connection structure 31 being connected between two adjacent first unit ring structures 1 and second unit ring structure 2, one end Connect the third " V " character form structure, " W " character form structure described in other end connection.It is connected to two adjacent second unit rings The both ends of second connection structure 32 between structure 2 are all connected with the third " V " character form structure, and one end is connected to two Between three " V " character form structures, the other end is connected to the centre of third " V " character form structure；It is connected to two adjacent first units The second connection structure 32 between ring structure 1 and second unit ring structure 2, one end connect first " V " character form structure and the Between two " V " character form structures, the other end is connected to the centre of third " V " character form structure.Further, first connection structure 31 one end connect the 4th loop end frame 13 or the 6th loop end frame 24, and the other end connects second loop end frame 121, institute The one end for stating the second connection structure 32 connects the 4th loop end frame 13 or the 6th loop end frame 24, and the other end connects five rings end knot Structure 21.Second connection structure 32 is in " n " character form structure, and " n " the character form structure both ends are separately connected Fourth Ring end Structure 13 or the 6th loop end frame 24 and the 5th loop end frame 21, more specifically, " n " the character form structure both ends are separately connected Center or fiveth loop end frame 21 of 6th loop end frame far from third straight-bar structure side are far from third straight-bar structure side The center of center and the 4th loop end frame 13 far from the first straight-bar structure and the second straight-bar structure side.First connection Structure 31 include be in " S " type structure 311 and straight-bar connecting rod 312, wherein：311 one end of " S " type structure connection the described 4th Center of the loop end frame 13 far from the first straight-bar structure and the second straight-bar structure side, or the 6th loop end frame of connection is far from third The center of straight-bar structure side, the other end connect the straight-bar connecting rod 312, and the straight-bar connecting rod 312 connects described second Center of the loop end frame 121 close to 123 side of the second straight-bar structure；The straight-bar connecting rod 312 is parallel to the net post The axial direction of shape structure.

Further, as shown in figs. 34, in the vertebral artery stent, in the vertebral artery stent there is drug to apply Layer 4, the medication coat 4 are coated in the first straight-bar structure 112 and/or the second straight-bar structure 123 and/or described the Three straight-bar structures 22 and/or the First Transition structure 113 and/or second transition structure 124 and/or the third transition Structure 23 and/or the 4th transition structure 14 and/or the 5th transition structure 125 and/or the 6th transition structure 25 Outer surface on.For example, the first straight-bar structure 112 and the second straight-bar structure 123 and/or the third straight-bar structure 22 and/or the First Transition structure 113 and/or second transition structure 124 and/or the third transition structure 23 and/ Or the appearance mask of the 4th transition structure 14 and/or the 5th transition structure 125 and/or the 6th transition structure 25 Fluted 4, the groove 4 carries the medication coat.Each first unit ring structure 1 or the second unit ring structure The length summation of the groove 4 on 2 accounts for the first unit ring structure 1 where it or the second unit ring structure 2 is total The 60%-75% of length, the width of the groove 4 account for the first straight-bar structure 112 and the second straight-bar knot where it Structure 123 and/or the third straight-bar structure 22 and/or the First Transition structure 113 and/or second transition structure 124 And/or the third transition structure 23 and/or the 4th transition structure 14 and/or the 5th transition structure 125 and/or institute The 45%-60% of the width of the 6th transition structure 25 is stated, the depth of the groove 4 accounts for the first straight-bar structure where it 112 and the second straight-bar structure 123 and/or the third straight-bar structure 22 and/or the First Transition structure 113 and/or Second transition structure 124 and/or the third transition structure 23 and/or the 4th transition structure 14 and/or described The 15%-30% of the thickness of five transition structures 125 and/or the 6th transition structure 25.

Unit ring structure (including first unit ring structure where the accumulative flute length for the groove for being loaded with medication coat accounts for it With second unit ring structure) total length 60%-75% when, the mechanical property for opening reeded bracket keeps good.When recessed When slot is too long, slotting position can be extended to too much at the wave crest of the first loop end frame or the second loop end frame, in stent-expansion When, with the increase of expansion pressure, the sectional area at the first loop end frame or the second loop end frame fluting is small, and stress ratio is not slotted place Greatly, there is phenomenon of rupture with the interface that do not slot in fluting.And if slot on entire unit ring structure, become bracket It is thin and cause bracket that corrosion fracture and fatigue fracture occurs.If groove length is too short, drug is unevenly distributed in slot and carries medicine Therapeutic effect is not achieved in amount.Therefore, the utility model had both reduced the wind of stent-expansion fracture to the rational design of groove length Danger, also increases the anticorrosive ability with fatigue fracture of bracket, and the design to depth of groove and width is to consider that bracket is whole Performance, if recess width and depth are too big, support intensity and fatigue durability not can guarantee, and are easily broken off, recess width and depth Degree is too small, then medication coat amount is very little, can not play the role for the treatment of.

Compared to the technology of existing treatment vertebral artery, the vertebral artery stent in present embodiment is had the following advantages that：This reality The vertebral artery stent first unit ring structure 1 that the mode of applying provides is by two different class wave components of waveform length and first " V " font Structure and " W " character form structure, are made of the first straight-bar structure 112 and the second straight-bar structure 123, wherein the second straight-bar knot respectively The length of structure 123 is shorter, can effectively reduce the mesh area between first unit ring structure 1, increases support force.In addition, First connection structure 31 is by the wave crest of the 4th loop end frame or the 6th loop end frame (i.e. far from the first straight-bar structure, second The center of straight-bar structure or third straight-bar structure side), it is connected at the wave base of " W " character form structure that (i.e. the second loop end frame leans on The center of nearly second straight-bar structure side), in " top is the bottom of to " connection, so that the first of two adjacent first unit ring structures The distance between " V " character form structure, the second " V " character form structure and " W " character form structure become smaller, to make the mesh of vertebral artery stent Area reduces, and increases the support force to lesion patch.

Secondly, the unique design of vertebral artery stent straight-bar connection rod structure increases the flexibility of entire bracket, vertebral artery Second connection structure of " n " shape at bracket both ends has certain elastic force, can reduce axial cripetura, reduces its rigidity for connecting both ends Degree, is not easily broken, improves the service life of entire bracket；First connection structure connects the straight of straightway by the curved section of serpentine Bar connecting rod is constituted, and straight-bar connecting rod is vertical with bracket longitudinal axis, and the design of connection structure improves the longitudinal compliance of bracket. When bracket passes through curved blood vessel, the serpentine curved portion and straight line portion of the first connection structure will allow bracket buckling, Substantially increase the mistake lesion ability of bracket.

Specifically, the medication coat 4 is coated in using one of spraying, dipping, trickle irrigation or roll compacting or various ways The outer surface of the net column structure, the medication coat 4 include biodegradable polymer and active medicine, and the biology can Carrier of the degradation polymer as the active medicine；The weight of the biodegradable polymer accounts for the weight of the medication coat The percentage of amount is 0.5-99.5%, and the percentage that the weight of the active medicine accounts for the weight of the medication coat is 0.5- 99.5%；The biodegradable polymer by one of homopolymer of D-ALPHA-Hydroxypropionic acid, Pfansteihl, glycolic and 6-caprolactone or It is arbitrarily two or more in a variety of and/or D-ALPHA-Hydroxypropionic acid, Pfansteihl, glycolic and 6-caprolactone that monomer is used as to be formed by copolymer One of or a variety of compositions；Or the biodegradable polymer is handed over by Poly D,L-lactide, poly- D- lactide, poly- L- third One of ester, polyglycolide, polymeric polyglycolide-polylactide and poly-epsilon-caprolactone or a variety of compositions；The biodegradable polymerization The weight average molecular weight of object is 20000~200000.The composition of the active medicine is rapamycin, taxol, Cilostazol, thiophene Chlorine is fixed, one of Triptolide and dexamethasone or a variety of.

Further, the material of the vertebral artery stent is cobalt-base alloys, stainless steel or titanium alloy.Preferably, vertebral artery The material of bracket is the cobalt-base alloys of good biocompatibility.The medication coat can slow release drug as needed, inhibit The hyperplasia and migration of smooth muscle cell, prevent vertebral artery restenosis.Vertebral artery stent uses " orientation " drug delivery technologies, drug Vascular wall is acted only on, while can prevent restenosis, and the process of vessel endothelialisation is not influenced, makes vertebral artery stent Safety and validity are taken into account on a more sophisticated level.The vertebral artery stent is mounted on a kind of " orientation " release drug In vertebral artery stent system, the vertebral artery stent system is made of the vertebral artery stent and transportation system, the vertebral artery Bracket is mounted in advance in the transportation system.The vertebral artery stent outer surface single side carrying medicaments coating, the medication coat position In the outer surface of vertebral artery stent net column structure, the medication coat includes biodegradable polymer and active medicine, institute The biodegradable polymer stated is the carrier of active medicine.

The vertebral artery stent that present embodiment provides can increase the support force to vertebral artery patch, prevent by spot Block squeezes after-poppet and collapses, and Restenosis occurs, while having good longitudinal compliance, can adapt to vascular morphology, And fatigue durability is good.

To sum up, the various configuration with vertebral artery stent is described in detail in above embodiment, and certainly, this is practical Cited configuration in novel including but not limited to above-mentioned implementation, it is any enterprising on the configuration basis that above embodiment provides The content of row transformation, belongs to the range that the utility model is protected.Those skilled in the art can be according to above embodiment Content draw inferences about other cases from one instance.

The utility model also provides a kind of production method of vertebral artery stent, as shown in Figure 1, the system of the vertebral artery stent Include as method：Form multiple first unit ring structures 1 and multiple second unit ring structures 2；Formed it is multiple have a straight-bar company The connection structure 3 of " S " the type structure 311 of extension bar 312 and a connection straight-bar connecting rod 312；By multiple first units Ring structure 1 and multiple 2 axial alignments of second unit ring structure；312 He of straight-bar connecting rod in each connection structure 3 Its described " S " type structure 311 connected is separately connected two first unit ring structures 1 and/or the second unit ring knot Structure 2, for example, a straight-bar connecting rod 312 and " S " the type structure 311 of its connection are separately connected two first unit ring knots Structure, alternatively, another straight-bar connecting rod 312 and " S " the type structure 311 of its connection are separately connected two second unit ring knots Structure；Or another straight-bar connecting rod 312 and " S " the type structure 311 of its connection are separately connected a first unit ring Structure and a second unit ring structure make multiple first unit ring structures 1 and multiple 2 shapes of second unit ring structure At a net column structure；When the connection structure 3 connects the first unit ring structure 1 and the second unit ring structure 2, make The straight-bar connecting rod 312 is arranged along the net post shape structure axial direction, and make the adjacent first unit ring structure 1 it Between mesh area be less than the adjacent second unit ring structure 2 between mesh area.

In a kind of vertebral artery stent provided by the utility model, pass through " V " of the adjacent first unit ring structure 1 The distance on top to top is less than the adjacent second unit ring structure 2 " V " character form structure between character form structure and " V " character form structure The distance on top to top between " V " character form structure reduces the mesh area between first unit ring structure 1, in contrast to existing There was only the technical solution of the big mesh of second unit ring structure in technology, effectively reduces the net of vertebral artery stent part-structure Hole area increases the support force to lesion patch；In addition, the connection structure 3 includes " S " type structure 311, it is easy to bracket Buckling improves the flexibility of bracket.When transfer gantry passes through curved blood vessel, crosses lesion ability and greatly improve, and work as After in stenter to implant body, it can be well adapted for vascular morphology, be bonded blood vessel.In addition, straight-bar connection rod structure can make it is described The direction of " S " type structure is fixed, and can be deeper into being attached inside first unit ring structure or second unit ring structure.This The vertebral artery stent that utility model provides, overcomes the deficiency of existing vertebral artery stent, meets the physiological characteristic of vertebral artery, make vertebra The safety of arterial bracket and validity are taken into account on a more sophisticated level.

The utility model provides a kind of drug stent of vertebral artery blood saccule expanding, by mount proximal end, distal end and The multiple supporting unit rings (including first unit ring structure and second unit ring structure) and connection structure of middle section form, in Between be partially distributed first unit ring structure, proximally and distally be distributed second unit ring structure, the supporting unit rings are by multiple lists First wave component, the unit wave is by reinforcing ring (the first loop end frame or the second loop end frame), straight bar section (including the first straight-bar knot Structure and the second straight-bar structure) and the transition structure of connection reinforcement ring and straight bar section form.

The mount proximal end and the supporting unit rings of distal end are made of " V " shape unit wave, support unit proximally and distally Connection structure between ring and adjacent supports cell rings is connected at the wave crest of two neighboring " V " shape unit wave, in " top is to top " Connection；The wave crest of the supporting unit rings of the middle section is connected at the wave base of adjacent supports cell rings, even in " top is the bottom of to " It connects.The supporting unit rings of the bracket middle section are made of two class waveforms, it is preferable that the support list of the bracket middle section Member ring is by " V " shape unit wave and the unit wave component of " W " shape, and wherein the waveform length of " V " shape unit wave is obviously than " W " shape unit wave Waveform length it is long.Preferably, " W " shape unit wave waveform length is shorter by 25~35% than " V " shape unit wave waveform length.

According to the utility model, the two kind wave components different by waveform length of the unit wave of bracket middle section, connection knot Structure is connected to the wave base of the unit wave in adjacent supports cell rings by the wave crest of the unit wave in a supporting unit rings, is in " top is the bottom of to " connection, so that the mesh area of bracket be made to reduce, increases so that the distance between adjacent two supporting unit rings become smaller To the support force of lesion patch.The straight bar section and transition structure are slightly wider than reinforcing ring.Preferably, straight bar section and transition structure Than reinforcing ring width 5~15%.

The mount proximal end and the connecting rod of distal end are " n " shape connecting rod.The connecting rod of the bracket middle section is by " s " The curved portion connection straight line portion composition of shape, wherein straightway is completely parallel to the longitudinal axis of bracket.

According to the utility model, the unique design of connecting rod of support structure increases the flexibility of bracket, bracket both ends " n " shape connecting rod has certain elastic force, can reduce axial cripetura；Connecting rod is made of the curved section of " s " shape connection straightway, Straightway and bracket longitudinal axes parallel, improve the longitudinal compliance of bracket, after stenter to implant vertebral artery, can be good at pasting Blood vessel is closed, the form of blood vessel is adapted to.And when bracket passes through curved blood vessel, the curved portion of connecting rod allows bracket longitudinally curved Song substantially increases the mistake lesion ability of bracket.

The supporting unit rings are provided with medicine-carrying trough by multiple unit wave components, the wave rod outer surface of the unit wave, special Sign is that the accumulative flute length of the medicine-carrying trough accounts for the 60%-75% of the wave pole length of supporting unit rings.Preferably, the load medicine The accumulative flute length of slot accounts for the 64%-70% of the wave pole length of supporting unit rings.According to the utility model, when tiring out for the medicine-carrying trough When meter flute length accounts for 75% or more of the wave pole length of supporting unit rings, the intravascular stent is in limit expansion destructive test and fatigue To occur phenomenon of rupture in test；When the accumulative flute length of the medicine-carrying trough accounts for 60% or less the wave pole length of supporting unit rings When, drug is unevenly distributed in slot, and the requirement of effectively treatment lesion is also not achieved in drugloading rate.

According to this manufacturing method, adjacent supports cell rings are connected by connecting rod forms tubular annular support.The medicine-carrying trough According to the specific requirement of slot length, reinforcing ring is predominantly located at the straight bar section or straight bar section and changeover portion of unit wave or extended to A bit of place.The reinforcing ring can be greater than the arc section of 180 degree for radian.The wave rod outer surface of each unit wave only one Medicine-carrying trough.The medicine-carrying trough can be elongate in shape.The medicine-carrying trough can be non-penetrative slot.The width of the medicine-carrying trough can To be the 45%~60% of unit wave straight bar section width.The depth of the medicine-carrying trough can be the 15%~30% of backing thickness. The medicine-carrying trough is cut by laser technology and is made.The vertebral artery stent is by cobalt-base alloys, stainless steel or magnesium alloy system At.

Embodiment

Embodiment 1

Vertebral artery stent is made of 7 first unit ring structures and 16 connection structures, wherein including 4 " n " shapes first Connection structure connects the second connection structure that straight line portion forms with 12 curved portions by " s " shape.Backing thickness is 100 μ M is cut into the groove for being loaded with medication coat using laser cutting technique, and groove width is 55 μm, and depth is 30 μm, is loaded with medication coat The accumulative flute length of groove account for the 60% of first unit ring structure total length.First straight-bar structure of first unit ring structure and The width of two straight-bar structures is 96 μm, and the ring width of the first loop end frame and the second loop end frame is 91 μm, the first straight-bar structure and Second straight-bar structure is slightly wider by about 5% than transition structure, and the length of the second straight-bar structure is shorter by 25% than the length of the first straight-bar structure.

Embodiment 2

Vertebral artery stent is made of 10 first unit ring structures and 22 connection structures, wherein including 4 " n " shapes first Connection structure connects the second connection structure that straight line portion forms with 18 curved portions by " s " shape.Backing thickness is 100 μ M is cut into the groove for being loaded with medication coat using laser cutting technique, and groove width is 60 μm, and depth is 25 μm, is loaded with medication coat The accumulative flute length of groove account for the 65% of first unit ring structure total length.First straight-bar structure of first unit ring structure and The width of two straight-bar structures is 107 μm, and the ring width of the first loop end frame and the second loop end frame is 91 μm, the first straight-bar structure and Second straight-bar structure is slightly wider by about 15% than transition structure, and the length of the second straight-bar structure is shorter than the length of the first straight-bar structure 35%.

Embodiment 3

Vertebral artery stent is made of 12 first unit ring structures and 20 connection structures, wherein including 8 " n " shapes first Connection structure connects the second connection structure that straight line portion forms with 16 curved portions by " s " shape.Backing thickness is 110 μ M is cut into the groove for being loaded with medication coat using laser cutting technique, and groove width is 50 μm, and depth is 30 μm, is loaded with medication coat The accumulative flute length of groove account for the 70% of first unit ring structure total length.First straight-bar structure of first unit ring structure and The width of two straight-bar structures is 100 μm, and the ring width of the first loop end frame and the second loop end frame is 91 μm, the first straight-bar structure and Second straight-bar structure is slightly wider by about 9% than transition structure, and the length of the second straight-bar structure is shorter by 30% than the length of the first straight-bar structure.

Embodiment 4

Vertebral artery stent is made of 12 first unit ring structures and 35 connection structures, wherein including 6 " n " shapes first Connection structure connects the second connection structure that straight line portion forms with 27 curved portions by " s " shape.Backing thickness is 95 μm, The groove for being loaded with medication coat is cut into using laser cutting technique, groove width is 55 μm, and depth is 20 μm, is loaded with medication coat The accumulative flute length of groove accounts for the 60% of first unit ring structure total length.First straight-bar structure of first unit ring structure and second The width of straight-bar structure is 102 μm, and the ring width of the first loop end frame and the second loop end frame is 91 μm, the first straight-bar structure and the Two straight-bar structures are slightly wider by about 11% than transition structure, and the length of the second straight-bar structure is shorter by 25% than the length of the first straight-bar structure.

Embodiment 5

Vertebral artery stent is made of 9 first unit ring structures and 24 connection structures, wherein including 6 " n " shapes first Connection structure connects the second connection structure that straight line portion forms with 18 curved portions by " s " shape.Backing thickness is 110 μ M is cut into the groove for being loaded with medication coat using laser cutting technique, and groove width is 55 μm, and depth is 32 μm, is loaded with medication coat The accumulative flute length of groove account for the 75% of first unit ring structure total length.First straight-bar structure of first unit ring structure and The width of two straight-bar structures is 100 μm, and the ring width of the first loop end frame and the second loop end frame is 95 μm, the first straight-bar structure and Second straight-bar structure is slightly wider by about 5% than transition structure, and the length of the second straight-bar structure is shorter by 35% than the length of the first straight-bar structure.

Each embodiment in this specification is described in a progressive manner, the highlights of each of the examples are with other The difference of embodiment, the same or similar parts in each embodiment may refer to each other.

Foregoing description is only the description to the utility model preferred embodiment, not to any limit of the scope of the utility model Fixed, any change, the modification that the those of ordinary skill in the utility model field does according to the disclosure above content belong to right and want Seek the protection scope of book.

Claims (18)

1. a kind of vertebral artery stent, which is characterized in that the vertebral artery stent includes multiple first unit ring structures, multiple second Unit ring structure and multiple connection structures, wherein：

Multiple first unit ring structures and multiple second unit ring structure axial alignments；

The connection structure connects multiple first unit ring structures and multiple second unit ring structures, makes multiple described First unit ring structure and multiple second unit ring structures form a net column structure；

The mesh area formed between the adjacent first unit ring structure be less than the adjacent second unit ring structure it Between the mesh area that is formed；

Each connection structure include one along the net post shape structure axial direction arrangement straight-bar connecting rod, and with it is described Connected " S " the type structure of straight-bar connecting rod.

2. vertebral artery stent as described in claim 1, which is characterized in that the first unit ring structure is located at the net post shape The centre of structure, the second unit ring structure are located at the both ends of the net column structure.

3. vertebral artery stent as described in claim 1, which is characterized in that the first unit ring structure includes multiple first nets Order member and multiple second net orders member, wherein：

The first net order member be first " V " character form structure, the second net order member be " W " character form structure, described first Net order member and the second net order member are spaced apart from each other arrangement along the circumferential direction of the net column structure, and are sequentially connected.

4. vertebral artery stent as claimed in claim 3, which is characterized in that each first net order member includes one first Loop end frame and two the first straight-bar structures, wherein：

First loop end frame passes through two First Transition structures respectively and is connected between two the first straight-bar structures, makes Two the first straight-bar structures form first " V " character form structure.

5. vertebral artery stent as claimed in claim 4, which is characterized in that each second net order member includes one second Loop end frame, two third loop end frames and four the second straight-bar structures, wherein：

Each third loop end frame pass through respectively two the second transition structures be connected to two the second straight-bar structures it Between, so that two the second straight-bar structures is formed second " V " character form structure；

Two third loop end frames are separately connected four the second straight-bar structures, form two described second " V " fonts Structure；

Second loop end frame is separately connected two described second " V " character form structures, makes two described second " V " character form structures " W " character form structure described in formation.

6. vertebral artery stent as claimed in claim 5, which is characterized in that the first net order member and the second net order It is connected between member by the 4th loop end frame.

7. vertebral artery stent as claimed in claim 6, which is characterized in that the second unit ring structure includes multiple five rings End structure and multiple third straight-bar structures, wherein：

5th loop end frame passes through two third transition structures respectively and is connected between two third straight-bar structures, makes Two third straight-bar structures form third " V " character form structure, and multiple " V " character form structures are along the net column structure Circumferential array, and be sequentially connected by the 6th loop end frame.

8. vertebral artery stent as claimed in claim 7, which is characterized in that the first straight-bar structure and third straight-bar structure Length is greater than the length of the second straight-bar structure, the second straight-bar structure and the first straight-bar structure or third straight-bar knot The lenth ratio of structure is between 0.65~0.75.

9. vertebral artery stent as claimed in claim 7, which is characterized in that first loop end frame, third ring end knot Structure, the 4th loop end frame, the 5th loop end frame and the 6th loop end frame are semi-circular ring, second ring end Structure is in the shape of two one sides of semi-circular ring connection, the first straight-bar structure, the second straight-bar structure and described the Three straight-bar structures are that section is rectangular column.

10. vertebral artery stent as claimed in claim 9, which is characterized in that first loop end frame, third ring end knot Structure, the 4th loop end frame, the 5th loop end frame and the 6th loop end frame ring width be less than first straight-bar The width of structure, the second straight-bar structure and the third straight-bar structure, the ring width of first loop end frame and described the The ratio of the width of rod structure, the second straight-bar structure or the third straight-bar structure is between 0.85~0.95 always.

11. vertebral artery stent as claimed in claim 9, which is characterized in that the ring width of second loop end frame is less than described The width of first straight-bar structure and the second straight-bar structure and the third straight-bar structure, the ring width of second loop end frame Ratio with the width of the first straight-bar structure, the second straight-bar structure or the third straight-bar structure is 0.85~0.95 Between.

12. vertebral artery stent as claimed in claim 7, which is characterized in that the connection structure includes multiple first connection knots Structure and multiple second connection structures, wherein：

It is connected between the first unit ring structure of adjacent two by first connection structure；

It is connected between the second unit ring structure of adjacent two by second connection structure；

Between the adjacent first unit ring structure and the second unit ring structure by first connection structure and/or The second connection structure connection.

13. vertebral artery stent as claimed in claim 12, which is characterized in that first connection structure one end connection described the The other end of four loop end frames or the 6th loop end frame, first connection structure connects second loop end frame；Institute The one end for stating the second connection structure connects the 4th loop end frame or the 6th loop end frame, other end connection the described 5th Loop end frame.

14. vertebral artery stent as claimed in claim 13, which is characterized in that first connection structure includes described " S " type Structure and the straight-bar connecting rod, wherein：

Described type structure one end " S " connects the 4th loop end frame or the 6th loop end frame far from the second straight-bar knot The center of structure or the third straight-bar structure side, the other end connect the straight-bar connecting rod, and the straight-bar connecting rod connects institute The second loop end frame is stated close to the center of the second straight-bar structure side；

The straight-bar connecting rod is parallel to the axial direction of the net column structure.

15. vertebral artery stent as claimed in claim 12, which is characterized in that second connection structure is " n " character form structure, Described " n " character form structure one end connects the 4th loop end frame or the 6th loop end frame far from the second straight-bar structure Or the center of the third straight-bar structure side, the other end connect the 5th loop end frame far from the third straight-bar structure one The center of side.

16. vertebral artery stent as claimed in claim 7, which is characterized in that have medication coat, institute in the vertebral artery stent State medication coat coated in the first straight-bar structure and/or the second straight-bar structure and/or the First Transition structure and/ Or on the outer surface of second transition structure and/or the third transition structure.

17. vertebral artery stent as claimed in claim 16, which is characterized in that the first straight-bar structure and/or described second Straight-bar structure and/or third straight-bar structure and/or the First Transition structure and/or second transition structure and/or described The outer surface of third transition structure has groove, and the groove carries the medication coat.

18. vertebral artery stent as claimed in claim 17, which is characterized in that each first unit ring structure or described The length summation of the groove on two unit ring structures accounts for the first unit ring structure or the second unit where it The 60%-75% of ring structure total length, the width of the groove account for the first straight-bar structure where it and described second straight Rod structure and/or third straight-bar structure and/or the First Transition structure and/or second transition structure and/or described The 45%-60% of the width of three transition structures, the depth of the groove account for the first straight-bar structure and described where it Two straight-bar structures and/or third straight-bar structure and/or the First Transition structure and/or second transition structure and/or institute State the 15%-30% of the thickness of third transition structure.