CN207882276U - A kind of detection device with solution storage device - Google Patents

Abstract

This practicality provides a kind of detection device with solution storage device, which is characterized in that the device includes solution storage device, and the solution storage device includes the cavity for accommodating solution reagent, wherein the diaphragm seal that the cavity is easy to puncture.It using the container memory of this practicality, can be independently present in except detection device, when needing to use, then be used cooperatively, chemical examination is facilitated to detect.

Description

A kind of detection device with solution storage device

Technical field

The utility model is related to a kind of device and method for detecting the analyte in fluid sample particularly to belong to A kind of device and method for detecting analyte in blood sample, and in particular to detection dress with solution storage device It sets.

Background technology

Following background technology is used to help reader and understands the utility model, and is not construed as the prior art.

Blood is always the common sample of warp of detection field, because containing many Biological indicators or being analyzed in blood Substance.In the fields POCT, if necessary to carry out the detection of analyte to blood, it is typically necessary the receipts for carrying out blood Collection, such as with the capillary on blood-taking needle broken skin skin, the acquisition of blood sample is carried out with blood sampling tool, then carries out blood The analysis of sample.Generally when individual carries out blood sample detection, blood taking needle is needed, take a blood sample tool and detection device, It usually can also carry the solution reagent of processing blood.These general apparatus are all packed in together, not only bad for packaging, and And when use, the trouble used, or the damage to human body can be caused.

This is improved with regard to the device in need to traditional detection blood sample, with the defect more than overcoming, allows use Person is more convenient and convenient.

Utility model content

In order to solve the problems in the existing technology, in a kind of detection fluid sample of the utility model offer, spy is standby to be Blood sample, analyte device, which includes：Solution storage punctures member for puncture solution storage Part.The puncturing of puncturing elements allows solution storage release solution.

In some preferred modes, which further includes hemostix for collecting blood sample and/or is used for Penetrating tissue punctures device (needle or sharp structure).

In some preferred modes, the hemostix is tubular structure.Preferably, hemostix includes blood sampling head, profit Blood sample is collected with the blood sampling head.Preferably, the hemostix is " L " shape.Preferably, the one of the hemostix End is connected with blood sampling head, and the other end is rod-like structure.Preferably, include allowing the rod-shaped knot of the other end of hemostix on detection means The rotatable fixed structure of structure.

In some preferred modes, the hemostix is arranged near the well of detection device.

In some preferred modes, the hemostix includes rod-like structure, and the blood sampling positioned at rod-like structure one end Head.

In some preferred modes, the other end of the rod-like structure includes bolt, includes inserting on detection means Hole, bolt are located in jack.

In some preferred modes, the bolt can rotate in jack.It is described in some preferred modes Detection device includes two bulge-structures, and the jack is located on two bulge-structures.

In some preferred modes, which is characterized in that the other end of the rod-like structure is located between two protrusions. In some preferred modes, the blood sampling head is located in well.

In some preferred modes, which further includes testing element, and blood sample can be detected by testing element The presence of middle analyte or quantity.

In some specific embodiments, solution storage or memory are devices for storing solution reagent, should Memory includes one for accommodating the actual cavity of solution treatment, the diaphragm seal that the opening of the cavity is easy to be punctured. Solution storage device independently exists alone with detection device, only when needing to use, solution storage device is allowed to be linked into detection The enterprising enforcement of device is used, in release solution to detection device.

In some preferred modes, the cavity of solution memory is surrounded by bottom and side wall, and the opening of cavity is thin Film seals.

In some preferred modes, groove structure is provided on side wall, the cavity which is directly opened in side wall is opened Mouthful along upper, in other words, groove is from along the bottom for extending to cavity.

In some preferred modes, while diaphragm seal is open, the groove opening of groove is also sealed, to be formed One hidden groove is on the side wall of cavity.

In some preferred modes, these grooves can be a plurality of, can be evenly distributed on the side wall of cavity, preferably , it is located at the inside of the side wall of cavity, can be directly contacted with processing solution reagent.

In some preferred modes, the cross section of the groove is " V "-shaped, " Z " font, " O " font, " L " word Shape.

In some preferred modes, it is characterised in that wherein groove is open with " V " shape, " Z " font opening, " O " word Shape be open, " L " font opening, the opening be located at cavity hatch along upper.

In some preferred modes, the opening of the film covering groove.

In some preferred modes, the madial wall of the cavity includes the groove structure described in one or more.

In some preferred modes, the cavity is rectangular cavity, and the opening of the cavity is also rectangular Shape, the madial wall corresponding to two short sides includes the groove structure.

In some preferred modes, institute is arranged in the centre position for being located at the madial wall corresponding to two short sides The groove structure stated.In some preferred modes, which further includes the receiving cavity for accommodating solution storage device, the receipts The bottom of reservoir body includes the fixed structure for fixed solution reservoir.In some preferred modes, the fixed knot Structure is located at the centre position of the bottom of receiving cavity.

In some preferred modes, the detection device includes upper plate and lower plate, and the testing element is located at upper plate Between lower plate.Preferred testing element includes sample application zone, reagent test area.

In some preferred modes, which includes testing element, and the detection device includes upper plate and lower plate, institute There is card slot element, the testing element to be located at the card slot element, wherein card slot member among the upper plate and lower plate stated Part is removably arranged in detection device.

In some preferred modes, the detection device includes a channel, the opening of the passage end and extraneous phase It is logical, it is communicated inside the opening and detection device of the other end, wherein the first end of the card slot element is located at the channel In.

In some preferred modes, which is characterized in that the channel is surrounded including two pass elements, one of them is logical Road element is located on upper plate, another pass element is located in lower plate.

In some preferred modes, which is characterized in that the outer surface in the channel includes puncturing elements.Described punctures Element is formed the edge structure of separation by the appearance outwardly convex of pass element.The very section of the edge structure and groove Cross section corresponds to, so as to be inserted into groove structure, to puncture film, release solution reagent.

In some preferred modes, the sample applying zone of the testing element is located in the card slot, wherein First end of the sample applying zone close to the card slot element.

In some preferred modes, the card slot element includes bolt, includes jack in lower plate, the bolt It is inserted into the jack, alternatively, the bolt can take out from jack.

In some preferred modes, which is characterized in that the bolt and card slot is structure as a whole.

In some preferred modes, which is characterized in that the bolt and card slot, which is integrated, to be molded.

In some preferred modes, which is characterized in that the cross section in the channel is rectangular parallelepiped structure.

In some preferred modes, which is characterized in that the device further includes solution memory, the memory The very section of cavity including diaphragm seal, the cavity is rectangular structure, the lancing device phase with channel outer surface It is corresponding

In some preferred modes, which includes puncturing device, is arranged in detection people's device, usually one End is fixed in detection device, and the other end is exposed, and lancet is contained in exposed part, for penetrating tissue to discharge blood. It is commonly to puncture mechanism to puncture device, and it includes a sharp needle generally to puncture device, is used for the function of penetrating tissue bloodletting.These Structure is all common structure, traditional structure.In some preferred modes, it is " T " shape structure to puncture device, is being examined It includes clamping structure to survey on device, punctures device and is buckled on clamping structure, and device fixation is punctured on detection means to allow.

On the other hand, the utility model provides a kind of method detecting analyte in blood sample, and this method includes：

Detection device is provided, which includes testing element, and solution storage, can puncture storage punctures member Part, wherein solution storage have the first fixed position and the second position in detection device；

Solution storage is allowed to be moved to the second position from first position；

In the process of moving, puncturing elements are allowed to puncture solution storage, to the solution in release solution storage.

Advantageous effect

Using the device of the utility model, blood sampling, buffer solution, detection device is allowed to be structure as a whole, can be completed with a step The collection and detection of blood sample.

Description of the drawings

Fig. 1 is the exploded perspective structural schematic diagram of the detection device in a specific implementation mode of the utility model.

Fig. 2 is the upper plate stereoscopic mechanism schematic diagram of the utility model one embodiment.

Fig. 3 is the structure amplification signal for rotating fixed hemostix in one specific implementation mode of the utility model Figure.

Fig. 4 is the hemostix dimensional structure diagram in one specific implementation mode of the utility model.

Fig. 5 is the hemostix of the utility model one embodiment and the fixed partial structurtes enlarged diagram of rotation in Fig. 1.

Fig. 6 is the package assembly of detection device shown in FIG. 1.

Fig. 7 is the dimensional structure diagram for puncturing device of the utility model one embodiment.

Fig. 8 is that puncture device and the detection device containing penetrating tissue of the utility model one embodiment fix stereochemical structure Schematic diagram.

Fig. 9 utility model one embodiment punctures device and detection device fixation three-dimensional assembling structure containing penetrating tissue Schematic diagram.

Figure 10 is the stereochemical structure signal of the detachable card slot element and lower plate in the utility model one embodiment Figure.

Figure 11 is that the dimensional structure diagram of the solution memory in the utility model one embodiment (is open unsealed Diaphragm seal).

Figure 12 is that the dimensional structure diagram of the solution memory in the utility model one embodiment (is open by sealed thin Film seals).

Figure 13 is the dimensional structure diagram of the storing apparatus for accommodating solution memory.

Figure 14 is position dimensional structure diagram of the solution memory in storing apparatus.

Figure 15 is position stereochemical structure signal of the solution memory (be open unsealed diaphragm seal) in storing apparatus Scheme (assembled).

Figure 16 is that the combination dimensional structure diagram of the detection device in the utility model one embodiment (does not contain solution Storage device).

Figure 17 is the partial structurtes enlarged diagram of the detection device shown by Figure 16.

Figure 18 is that the puncturing elements of the detection device in the utility model one embodiment puncture solution memory release liquid The status architecture schematic diagram of body.

Figure 19 is the testing element structural schematic diagram of the utility model.

Specific implementation mode

Below to the utility model is related to structure or these used technical terms be described further.These are said Bright is only how to be realized in such a way that way of example illustrates the utility model, can not be to the utility model Constitute any limitation.

Detection

Detection indicates chemical examination or tests a kind of substance or material whether there is, for example, but it is not limited to this, chemical substance, Organic compound, inorganic compound, metabolism product, drug or drug metabolite, organic organization or organic organization generation Thank object, nucleic acid, protein or polymer.In addition, detection indicates test substances or the quantity of material.Furtherly, table is gone back in chemical examination Show immune detection, chemical detection, enzyme detection etc..

Testing element

A variety of testing elements 70 can be in combination application to the utility model.Testing element includes test-strips, analysis test Item can there are many forms, for example, by using immune or test chemical form, for detecting the analyte in sample, such as poison Product or the correlative metabolites for indicating physical condition.In some forms, test-strips are with sample application zone, reagent area and testing result The water-absorbing material in area.Sample is added to sample application zone, and reagent area is flowed into using capillarity.In reagent area, sample dissolving examination Agent and it is mixed can be used for detect analyte (if there are analytes in sample).The sample for carrying reagent at this time continues It flow to test results zone.Other reagent is fixed on test results zone.These are fixed on the reagent of detection zone and are divided Analysis object (if present) is reacted and is combined with the first reagent of reagent area.In noncompetitive test format, such as There are analytes just will produce signal in fruit sample, if analyte is not present, does not generate signal.Shape is detected in competition In formula, signal is generated if analyte is not present in sample, signal is not generated if if there is analyte.This practicality is new Type is suitable for various analytical forms.

When the test element is a test strip, it can be made of water suction or unwetted property material, and test-strips can be with Using multiple material, it to be used for the transmission of liquid.A kind of material of test-strips can be superimposed upon on another test strip material, example Such as, filter paper overlaid is on nitrocellulose.Alternatively, a region at least containing a kind of material in test-strips is located at another kind at least After a kind of region of different materials.In this case, liquid is circulation between each region, can phase between them It is mutually superimposed or is not superimposed.Material in test-strips can be fixed on such as support of plastics liner or hard surface, It can holding force to reinforce test-strips.

In the embodiment that some detected materials are detected by signal generation system (as at least one enzyme be detected Specific reaction occurs for object), at least one substance for generating signal can be attracted to the analyte detection zone of test-strips, just It is specifically adsorbed on the material of test-strips as described above the same.Additionally, there are in the sample application zone, reagent area, quilt of test-strips Analyte detection zone, or generation signal throughout entire test-strips substance can pre-process in advance at one of test-strips or On multiple materials.It can be by the way that the substance solution for generating signal to be added to the surface of application area or by one or more of test-strips Material is immersed in signal solutions and realizes.After test-strips add signal solutions or impregnate in the solution, test-strips are dried It is dry.In addition, above method is present in the sample application zone, reagent area, analyte detection zone of test-strips, or throughout entire test The substance of the generation signal of item can be pre-processed in advance on one or more materials of test-strips.Additionally, there are add in test-strips The semiochemicals of sample area, reagent area or detection zone can be added to one or more tables of test strip material as labelled reagent Face.

Each region of test-strips can be arranged as follows：Such as Figure 19, sample application zone 701, at least one reagent area, at least one detection Fruiting area 702, at least one control zone, at least one detection of adulterations area and liquid absorption area 703.If detection zone includes one Control zone, preferably control zone are located at after the analyte detection zone of test results zone.All these areas or combinations thereof can be In a kind of single test strips containing material.In addition, these areas are made from a variety of materials, and the direction connection transmitted by liquid Together.For example, different zones can directly or indirectly carry out liquid transmission.In the present example, different areas can be along liquid The direction end that body transmits is connected with end, or is overlapped mutually along liquid direction of transfer, or is connected by other materials, example Such as connect dielectric material (preferably water-absorbing material such as filter paper, glass fibre or nitrocellulose).When with connecting material, even Material, the end comprising each region and the joining distal ends but liquid of the end comprising each region and joining distal ends can be made not by connecing material The material of circulation or the material not circulated comprising each region overlapped (such as, but not limited to from the beginning to the end be overlapped) but liquid, Form liquid communication.

If test-strips contain detection of adulterations control zone, which can be placed on before or after result detection zone.Work as knot Control zone is contained in fruit judgement area, and adulterated control zone is preferably positioned at before control zone, may not be such situation.This practicality Novel one embodiment, test-strips are the control test-strips for judging and/or controlling for adulteration analyte, and adulterated control zone can be with Before or after control zone, it is preferably placed at before control zone.

In specific embodiment of the present utility model, testing element or test-strips can be located at testing element carrier In, carrier can be on the detachable card slot element 40 such as the lower plate 11 in Fig. 1.Preferably, under card slot element 40 is located at On plate, or between upper plate 10 and lower plate 11.

Sample

The sample that can be detected with the detection device of the utility model includes biofluid (such as casing fluids or clinic Sample).Either fluid sample can derive from the sample of solid-state or semisolid, including excreta, biological tissue to liquid sample And food samples.The sample of solid-state or semisolid can be converted to liquid sample using any method appropriate, such as mix, It smashs to pieces, macerate, being incubated, dissolving or (such as water, phosphate solution or other buffer solutions) utilize enzymolysis in a suitable solution Act on digestion of solid sample." biological sample " includes deriving from animal, plant and food samples, such as including deriving from people or dynamic The urine of object, saliva, blood and its ingredient, spinal fluid, vaginal fluid, sperm, excrement, sweat, secretion, tissue, organ, tumor, The culture of tissue and organ, cell culture and medium.Preferred biological sample is urine.Food samples include the object of food processing Matter, final products, meat, cheese, wine, milk and reference water.Plant sample includes being derived from any plant, plant tissue, and plant is thin Born of the same parents' culture and medium." environmental samples " are from environment (for example, coming from lake or the liquid sample of other water bodys, sewage Sample, soil property sample, underground water, seawater and waste liquid sample).Environmental samples may also include sewage or other waste water.Utilize this Utility model and suitable detecting element, can detect any analyte.It is detected in blood preferably by the utility model Analyte.

Analyte

Can include some haptens substances, these haptens packets with the example of the analyte involved in the utility model Include drugs (such as drug abuse)." drug abuse " (DOA) refers to that the work of paralysis nerve (is usually played in non-medical destination using drug With).Abusing these drugs can cause body ＆ mind to be damaged, and generate dependence, addicted and/or dead.Drug is indiscriminate Example includes cocaine；Amphetamine AMP is (for example, black beauty, white amphetamine tablet, dextroamphetamine, dextrorotation Amphetamine tablet, Beans)；Crystal methamphetamine MET (crank, meth, crystal, speed)；Barbiturate BAR (such as Valium, Roche Pharmaceuticals, Nutley, New Jersey)；Sedative (adjuvant of sleeping Product)；Lysergic acid diethylamide (LSD)；Inhibitor (downers, goofballs, barbs, blue devils, yellow Jackets, methaqualone)；The anti-antidepressant of tricyclic antidepressants (TCA, i.e. imipramine, amitriptyline and doxepin)；Two methylenedioxy groups Methylaniline MDMA；Phencyclidine (PCP)；Tetrahydrocannabinol (THC, pot, dope, hash, weed, etc..)；Opiate (i.e. morphine MOP or opium, cocaine COC, heroin, hydroxyl dihydrocodeinone)；Anxiolytic and hypnotic sedative agent resist Anxiety medicine is that one kind is mainly used for anxiety reduction, anxiety, fear, sets the mind at rest, has the drug of hypnosis sedation, including benzene concurrently Diazepine BZO (benzodiazepines), atypia BZ classes, fusion phenodiazine NB23C classes, benzene nitrogen Zhuo class, BZ receptors are matched Body class, open loop BZ classes, diphenylmethane derivatives, piperazine carboxylic acid salt, piperidine carboxylic acid salt, Kui oxazoline ketone, thiazine and thiazole Derivative, other heterocyclics, imidazole type calmness/anodyne (such as hydroxyl dihydrocodeinone OXY, methadone MTD), propylene glycol derive Object-carbamates, aliphatic compound, anthracene derivative etc..It can be used for examining using the detection device of the utility model The detection for belonging to medical usage but being easy overdose is surveyed, such as tricyclic antidepressant (imipramine or the like) and acetyl ammonia Base phenol etc..These drugs can resolve into different small-molecule substances after being absorbed by the body, these small-molecule substances be present in blood, In the body fluid such as urine, saliva, sweat or part body fluid there are above-mentioned small-molecule substances.

The analyte detected with the utility model includes but not limited to creatinine, bilirubin, nitrite, albumen (non-specificity), hormone (for example, human chorionic promotes sex hormone, luteinizing hormone, follicular stimulating hormone etc.), blood, white blood cell, Sugar, heavy metal or toxin, bacterial components (albumen or glucide as being directed to specific bacterial, such as such as colon bacillus 0157： H7, staphylococcus, salmonella, fusobacterium, Campylobacter, L.monocytogenes, vibrio or cactus bacillus) and urine In sample with the relevant substance of physiological characteristic, such as pH and proportion.Other any Clinical Urinary chemical analyses are all examined using lateral flow Survey form cooperation utility model device is detected.

Detection device

The detection device of the utility model includes testing element 70, and testing element can be used for detecting sample, such as blood Analyte whether there is in sample.In some modes, detection device includes upper plate 10 and lower plate 11, and upper plate 10 includes adding Sample hole 102 and testing result read hole 101, and lower plate includes that some are inserted into hole, is inserted into card slot element 40 inserting in the hole, tests Element is located in the slot structure of card slot 40.

Hemostix

In some preferred modes, detection device includes one and is used for hemostix 20, and hemostix can be located at well 102 Attachment.Preferably, hemostix can be rotated around detection device, when needing collector to carry out taking blood sample It waits, allows blood sampling head 202 to take sample by rotation, then carry out negative direction rotation, sample is added close to well 102 This, such as blood, serum, blood plasma or other types of sample.After addition blood sample, puncture molten in solution memory Liquid, to handle sample, to carry out subsequent detection.

In preferred mode, the edge of the upper plate 10 of detection device includes two raised (figures of block structure 104,105 3).There is a certain distance, this is specifically less times greater than the diameter of the tubular structure 203 of hemostix 20 between two block structures. There are two rotating holes 106 for tool in even block structure.As shown in figure 4, hemostix includes blood sampling head 202 and tubular structure 203, blood sampling head is located at one end of tubular structure 203, includes the structure of even bolt sample 204 on the tubular structure 203 of the other end, Bolt or embolus 204 are located in rotating hole 106, and such hemostix is fixed on detection means by rotation.In order to facilitate assembling With use, blood sampling head 202 connect with tubular structure 203 by a connecting rod 201, formation " L " shape hemostix.When into When row assembling, the blood sampling head 202 of hemostix is allowed to be located in well 102, the protection of well 102 can be allowed to take a blood sample in this way Head is not damaged.When needing to take sample, hemostix is allowed to be rotated outward along rotating hole 106, far from well, in this way It allows blood sampling head to take sample, after acquisition, is rotated further along negative direction, during blood sampling head 202 enters 102 in well, added The sample applying zone 701 of the corresponding testing element in sample hole, to allow sample to be applied in the applying zone 701 of testing element (as shown in Figure 5).

Puncture device

In some preferred modes, which further includes that firmly penetrating tissue bloodletting punctures device 50, this is punctured Device includes a sharp needle 53, can puncture blood vessel with penetrating tissue, to discharge blood sample in tissue (such as Fig. 7, Fig. 8 and Shown in Fig. 9).And device 50 is punctured similar to T shape.With clamp rail 51 and ontology 52.In a preferred mode, device is punctured 20 are located at one end of detection device, are partly located in detection device, partly expose outside, direct with puncturing when operation in this way One end of device is directed at the position of tissue, such as finger tip, carries out puncturing behavior, once punctured, adopting with hemostix 20 immediately First 202 are taken to carry out taking blood sample.In order to which the fixed device 50 that punctures is with detection device, can be set in one end side of lower plate 11 Clamping structure is set, which has buckle 116 and opening 115, forms clamping structure together.The clamp rail 51 for puncturing device can To slide into buckle structure 116, ontology snaps fit onto in opening 115, punctures device to allow and is fixed in detection device (Fig. 9 institutes Show).When needing penetrating tissue, one end alignment tissue with needle for puncturing device is directly allowed to be punctured, to discharge Blood sample.

Detachable card slot element

Detection device includes that upper plate 10 and lower plate 11 assemble, wherein testing element is located in detection device, specifically, can To allow testing element 70 between upper plate and lower plate.In some preferred modes, detection device includes one detachable Card slot element 40, which is connected in lower plate 11, and testing element 70 is located in the card slot 403 of card slot element 40 (such as Fig. 1).Card slot element 40 includes card slot ontology, and ontology includes card slot 403, includes some pin configurations in the bottom of ontology 405,406,407, during these pin configurations are inserted into 112,113,117 in the corresponding jack of lower plate, in this way, allowing card slot element 40 are not located under the plane where lower plate, and the upper plan-position higher than where lower plate.Some cross can be arranged in card slot ontology To the structure of beam 404,402, beam structure connects pin 406 and 407.In this way, pin 407 is inserted into the jack 112 of lower plate In, pin 406 is inserted into the jack 113 of lower plate, and pin 405 is inserted into the jack 117 of lower plate；Card slot is secured in this way Element.Allow card slot element distances lower plate that there is certain height simultaneously, this is to allow the card slot in card slot element to be located at channel Among 210, while close to the upper surface of channel part.In the position relationship for elaborating channel and card slot next time.

Puncturing elements and channel

As shown in figs. 16-17, detection device includes puncturing elements.The puncturing elements are located at 90 outer surface of channel.Specifically It says, detection device includes that upper plate 10 and lower plate 11 form, and channel 90 is also made of two parts, and upper plate pass element 103 is under Board channel element 114 forms, and channel 90 is formed by the structure assembling of two similar card slots, and passage end opening is external, The other end leads to the inside of detection device.The shape that two elements in formation channel are combined into channel can be arbitrary shape, Such as round, square, rectangle, ellipse or diamond shape.No matter which kind of shape, the chamber of the shape and solution storage device The shape of body is corresponding so that it is convenient to these 90 shapes of channel enter in cavity, to occupy the volume of cavity, solution is allowed to discharge Out.The channel is outstanding from detection device one end, but the channel is generally within the point midway in the cross section of detection device (such as Figure 16).In some modes, in 301 in the cavity that channel enters solution memory, channel 90 is forced liquid through Be flowed into detection device, in order to allow liquid to be flowed into detection device by channel as far as possible, so, the formation in channel and 301 shape, volume are about the same in the cavity of solution memory.Moreover, preferably, shape is the same, and only size is variant, Allow channel to occupy the volume of all cavitys 301 in this way, and liquid can only be flowed into detection device from channel 90 go without It leaks, can elaborate on how to realize below.

There is opening 210, solution to be flowed into detection device by opening in channel 90.Solution is flowed into detection device Purpose be in order to handle the sample on testing element, so, in the present invention, testing element is located at the card of card slot element 40 In slot, solution is allowed to be flowed into card slot for convenience, so, the card slot 403 of one end of card slot element is located in channel, and leans on The upper end in nearly channel, i.e., close to the interior specific surface of upper plate pass element 103, in this way, when channel enters in solution cavity, card The card slot 403 of one end of slot element is also entered with channel in solution cavity.The solution for entering channel so is also easy for It is flowed on card slot, to allow the sample applying zone of testing element to have solution absorption, to handle blood sample.

In order to allow channel to enter solution cavity, and the opening of general solution cavity is by diaphragm seal, this is just needed Puncturing elements are arranged to puncture film in the outer surface in channel.As shown in figure 17, the upper plate pass element 103 and lower plate in channel are formed Pass element 114 combines and forms channel 90.And upper plate pass element has an edge thin slice 211 outstanding, lower board channel member Part also has edge thin slice 250 outstanding, and after two element combination overlappings, even an edge thin slice 211 and 250 is overlapped composition blade Shape punctures structure 212.This punctures structure has sharp blade structure, and the blade knot similar to the structure 212 of blade Structure genesis analysis is in the outer surface in channel, for puncturing the film of sealing solution cavity.

Certainly, it other than such structure, punctures structure and can also be that other any sharp structures, this structure are set The outer surface in the channel set when allowing channel to enter in solution cavity either before or the same time allows and punctures member Part punctures film, to be easier to allow channel to enter in solution cavity body.The shape in the cross section of edge structure can be a variety of Different shapes, for example, " V " font, " Z " font, " O " font, " L " font.It is corresponding, also there is correspondence on solution storage chamber Suitable edge structure be inserted into groove structure, allow edge structure smoothly to be inserted into this way, on the one hand play puncturing sealed thin On the other hand the effect of film can also allow channel design can smoothly enter into cavity.

Solution storage device

In some preferred modes, the detection device of the utility model includes one and accommodates solution storage device 30.One In some preferred modes, the solution storage device 30 is the shape of a substantially square, one there are six face besieged city of tool Cavity 308, there are one opening 301, which is sealed the cavity 308 tool by film 305.In contrast, sealed opening Film 305 is to be easy the film punctured, such as aluminium foil film, plastic film, is sealed in the form of laser or thermoplastic envelope. Before sealing, solution is full of or poured in cavity 308, which is used for handling the solution of sample, such as blood sample, molten Liquid can be the solution for changing sample PH, can also be to remove impurity or interference component in sample.Solution can contain any The effect of suitable ingredient or suitable chemical substance, these solution can be with a kind of effect, can also be to play a variety of works With.

In some preferred modes, one or more of groove structures 311 are set on the madial wall of cavity, the groove The edge structure of the outer surface of structure and channel design is adapted.Corresponding, groove structure is arranged on the madial wall of cavity, tool There are certain depth and shape, for depth edge structure can be allowed to be inserted into, the shape in cross section and the cross section of edge structure are suitable It answers, edge structure is facilitated smoothly to be inserted into, guiding channel normally enters excludes liquid in cavity 308, to allow liquid to enter To in sensible, hence into in the card slot in the card slot element in channel, the sample to moisten testing element applies Region.Preferably, the one end open of groove structure be opened in cavity along 310, so along 310 formed a notch 303, When sealing film seal cavity opening 301 when, part sealing need and along 310 sealing, sealing along when, also simultaneously Notch 303 and another groove opening 302 (Figure 12) are sealed up, actually just conceals the opening and groove sheet of groove in this way Body.

In one embodiment of the utility model, solution cavity is the shape of substantially cuboid, the cross section of cavity For rectangular shape, such as shown in FIG. 11 and 12, a groove structure, chamber are respectively set on the madial wall on two short sides The cross section of body is also that the shape of the very section in rectangular shape and channel is substantially the same.In this way, when channel is inserted into cavity In 301, it is located at before the edge structure 212 of the protrusion of channel outer surface and the edge structure of 205 and 211 formation first It is inserted into the opening 303 and 302 of groove, to puncture the film of seal cavity opening 301, with further channel 90 It is inserted into, blade plays a part of getting at navigation, and guiding channel is entered along fixed track in cavity, with channel 90 Into, force the solution in cavity to enter in channel, hence into the card slot to the card slot element in channel, to Moisten the sample applying zone of testing element.

In conjunction with Figure 16 and Figure 13-15, solution cavity 308 is arranged in contained structure 60, which is also The cavity of a general rectangular, the bottom of cavity include a fixed structure 602, the shape of the fixed structure 602 and The shape of solution cavity 308 adapts to, and solution cavity 308 can be smoothly mounted in contained structure 60 (Figure 14 and Figure 15). In the cavity of contained structure, fixed structure is centrally located, and both sides reserve extra space.Generally, include solution Contained structure is nested into inspection by 60 individualism of contained structure of cavity when needing to apply solution on testing element The one end in device channel, this when are surveyed, 210 one end of opening in channel is directed at the solution cavity in contained structure 60, and sealing The sealing film of solution cavity corresponds to.It is inserted into further, contained structure is entered by channel in solution cavity 308, is held The remaining both sides space to be preserved of micro-nano structure, to preferably allow the aperture position of channel alignment solution cavity.

As described above, with the insertion in channel, positioned at the opening 303 for puncturing structure and being firstly inserted into groove of pathway edge On 302, to puncture the film of seal cavity opening 301, with the insertion in further channel 90, blade, which plays, to be got at The effect of navigation, guiding channel are entered along fixed track in cavity, with the entrance in channel 90, are forced molten in cavity Liquid enters in channel, hence into the card slot to the card slot element in channel, to moisten the sample of testing element Applying zone (as shown in figure 18).The one end 801 containing channel 90 in the interior not space of contained structure and size and detection device Shape cooperation, be just stably fixed on one end to contained structure.

Puncture device

In some preferred modes, which includes puncturing device 20, is arranged on the another of solution storage device 30 It holds (Fig. 1 and Figure 14).It is commonly to puncture mechanism to puncture device, and it includes a sharp needle generally to puncture device, is used for penetrating tissue The function of bloodletting.These structures are all common structure, traditional structure.

Detection method

Below in conjunction with the accompanying drawings come illustrate how carry out fluid sample in analyte detection.

Prepare detection device, such as Figure 16 or detection device shown in Fig. 9, including punctures device 50 (such as Figure 10,9 institutes Show), hemostix 20 and solution storage device 30, and the puncturing elements on channel design both sides on detection means are set.Blood sampling Device is flexibly connected in the way of Figures 5 and 6 with the upper plate of detection device, such as Figure 16, this is in time at the blood sampling head of hemostix In well, to be protected.In addition, channel is exposed at outside detection device, and 30 individualism of solution storage device, it is fixed Fixed position in storing apparatus 60, as shown in figure 15, the diaphragm seal that the cavity 30 of storing solution is easy to puncture such as is schemed Shown in 12.

When needing detection, first with device 50 is punctured come penetrating tissue, such as finger tip, blood sample outflow has been waited Afterwards, blood sampling head is rotated out of from well 102, such as with receiving the bar 203 for moving or moving hemostix, to allow blood sampling head The acquisition of blood sample is carried out, then negative direction rotates again, applies blood sample to sample application well 102, sample-adding is completed Afterwards, blood sampling head at this time is still located in well.

At this point, solution storage device 30 is in the state detached with detection device, wait after applying sample, allows and accommodate solution The storing apparatus (Figure 15) of memory 30 is sleeved in channel design, and the one end in channel is allowed to be directed at solution receiving cavity by diaphragm seal One end, push solution storage device 30 from first movement to the second position, since puncturing elements are located on channel, it is slotting to puncture structure The seal entered to the both sides of solution receiving cavity goes out, and is further inserted into solution receiving cavity with channel, punctures structure depth Enter to be inserted into, to force solution to enter in channel from the opening in channel, because card slot element passes through close to the opening in channel The solution that access portal enters also enters in card slot therewith, then flows into sample applying zone, is flowed into applying zone On solution flow through 10 corresponding sample applying zone of sample application well, sample disposed thereon is handled, to complete Test or chemical examination.

Above method is to be directed to blood sample, when not being blood sample, it may not be necessary to puncture device, and directly use Hemostix carries out taking for sample, such as saliva, excrement etc. can such as be carried out above for the explanation of sample with hemostix It takes.

In the case where lacking any element specifically disclosed herein, limitation, may be implemented illustrated and described herein Utility model.Used terms and expressions method is used as the term of explanation and unrestricted, and is not intended in these terms Any equivalent of shown and described feature or part thereof with exclusion in the use of representation, and should be realized that various change Type is all feasible in the scope of the utility model.It is therefore to be understood that although passing through various embodiments and optional feature The utility model is specifically disclosed, but the modifications and variations of concept as described herein can be by those of ordinary skill in the art institute Using, and think that these modifications and variations are fallen within the scope of the utility model of the appended claims restriction.

It is described herein or record article, patent, patent application and every other document and can electronically obtain The content of information include herein by reference, just as each individual publication by specific and single in full to a certain extent Solely point out by reference.Applicant retains from any of any this article, patent, patent application or other documents And all material and information are incorporated into the right in the application.

Claims (10)

1. a kind of detection device with solution storage device, which is characterized in that the device includes solution storage device, the solution Reservoir includes the cavity for accommodating solution reagent, wherein the diaphragm seal that the cavity is easy to puncture, wherein described Solution storage device independently exists alone with detection device.

2. detection device according to claim 1, which is characterized in that the cavity includes the side wall for surrounding cavity, Groove structure is set on side wall.

3. detection device according to claim 2, which is characterized in that the cross section of the groove is " V "-shaped, " Z " Font, " O " font, " L " font.

4. detection device according to claim 3, it is characterised in that wherein groove is open with " V " shape, and " Z " font is opened Mouthful, " O " font opening, " L " font opening, the opening be located at cavity hatch along upper.

5. detection device according to claim 4, which is characterized in that the film covering groove structure is opened Mouthful.

6. detection device according to claim 4, which is characterized in that the madial wall of the cavity is including one or more A groove structure.

7. detection device according to claim 6, which is characterized in that the cavity is rectangular cavity, described The opening of cavity is also rectangular, and the madial wall corresponding to two short sides includes the groove structure.

8. according to the detection device described in claim 7, which is characterized in that the madial wall being located at corresponding to two short sides The centre position setting groove structure.

9. detection device according to claim 1, which is characterized in that the device further includes for accommodating solution storage device Cavity is accommodated, the bottom of the receiving cavity includes the fixed structure for fixed solution reservoir.

10. detection device according to claim 9, which is characterized in that the fixed structure is located at the bottom of receiving cavity The centre position in portion.