CN207837719U - Hyperthermic intraperitoneal perfusion chemotherapy device - Google Patents
Hyperthermic intraperitoneal perfusion chemotherapy device Download PDFInfo
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- CN207837719U CN207837719U CN201720371965.0U CN201720371965U CN207837719U CN 207837719 U CN207837719 U CN 207837719U CN 201720371965 U CN201720371965 U CN 201720371965U CN 207837719 U CN207837719 U CN 207837719U
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- heating
- water tank
- return
- heating water
- liquid
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Abstract
The utility model discloses a kind of hyperthermic intraperitoneal perfusion chemotherapy devices,Including heating mechanism,Controller,Medicine liquid tank and waste liquid tank,Controller is electrically connected with heating mechanism,The heating mechanism includes heating water tank,Return and the liquor piping being placed in heating water tank,Inlet and outlet are provided in heating water tank,The both ends of return are connected to inlet and outlet respectively,It is equipped with heat conductor on the peripheral surface of the return,It is glued with ceramic heating plate on the peripheral surface of heat conductor,First temperature probe is additionally provided on heat conductor,One end of the liquor piping is filled by drug-feeding tube and liquid and is connected,The other end is connect by drug discharging tube with human abdominal cavity,Useless medicine, which is filled, to be connect by useless pencil with human abdominal cavity,Second temperature probe and third temp probe are respectively arranged in heating water tank and drug discharging tube,First temperature probe,Second temperature probe and third temp probe are electrically connected with the controller.
Description
Technical field
The utility model is related to the field of medical instrument technology, more particularly, to a kind of hyperthermic intraperitoneal perfusion chemotherapy device.
Background technology
Currently, different cell lines have very big difference to the sensibility of thermotherapy, but malignant tumour is to thermotherapy in general
There is higher sensibility.Do not find the marked difference between normal cell and cancer cell to thermal response so far, but it is extracellular
Environment can change its sensibility to thermotherapy.Exactly because the difference of extracellular environment, related studies have shown that normal structure is thin
Born of the same parents are resistant to 47 DEG C of high temperature for continuing 1 hour, and malignant cell only continues to may occur in which irreversible damage in 1 hour at 43 DEG C
Evil, therefore 43 DEG C and 47 DEG C of critical-temperatures for being known respectively as malignant tumour and normal structure irreversible lesion;Furthermore abdominal cavity fills
Heat injection chemotherapy has high selection local chemotherapy pharmacokinetic characteristics.Peritoneal fluid anticancer concentration is the 10-100 of blood concentration around
Times, the anticarcinogen of high concentration is conducive to directly kill intraperitoneal free cancer cell and minimum cancer stove, and body circulation concentration is low subtracts
Less or avoid whole body toxic side effect.Hyperthermic intraperitoneal perfusion chemotherapy is exactly this to temperature tolerance using malignant tumour and normal structure
Particularity and Chemotherapy and eliminate cancer cell.
Individual thermotherapy or systemic chemotherapy, can not effectively remove the cancer cell of patient's body, for postoperative free cancer
Cell is even more helpless.Hyperthermic intraperitoneal perfusion chemotherapy is to the selective destruction of cancer cell, because of anatomic differences, tumor tissues blood
Stream is less than normal structure blood flow, nutritional deficiency.And cancer cell generally be in chronic hypoxia acidic environment in, the volume of tumour and
Histological type is also to determine the most important factor of its pH value, if not considering histological type, the average pH values of tumour are 7.06
±0.5 ;Gross tumor volume < 20cm3, pH values increase with gross tumor volume and are increased;Gross tumor volume > 20cm3, pH values are with swollen
Knurl product increases and reduces.The cancer cell-apoptosis that the thermotherapy that acidic environment contributes to causes and the interference to Cancer Cell cycle.Heating
Tumor blood flow is less afterwards, environment change, anoxic, malnutrition, pH declines, cell membrane disruption, nucleic acid in tumor tissues
Form obstacle;Tumor tissues decomposition product stimulates immune system, organism immune response enhancing.At one about tumour oxygenation status
Zoopery in observe, when 44 DEG C of thermotherapy temperature <, peomotes hemoperfusion, improves oxygenation;As temperature >
Lead to tumor vascular destruction at 44 DEG C, aggravate anaerobic condition, under tumor tissues anaerobic condition, Oligemia the result is that
Delay cooling time is organized, tumour is then made to obtain more thermal energy, this is conducive to kill cancer cell.Thermokinetics making of effect
It treats medicine to be combined with cancer target cell, increased activity, to enhance certain anticancer drug reactivities.Change cancer cell membrane permeability,
Chemotherapeutic is set effectively to penetrate into the cell.The reparation of tumour cell after inhibition chemotherapy increases some drugs and is handed over DNA of tumor cell
Connection enhances killing tumor cell effect.Large capacity chemotherapy can more increase chemotherapeutic to sensitivity of tumor cells after abdominal cavity heating.Tumor
Body center is mostly anoxic cell, but since pH values are low sensitive to thermotherapy;On the contrary, knurl peripheral cells are to chemosensitivity, therefore the two
Complementation is combined.Intracellular pH value also plays an important role in the heat sensitivity for adjusting cell.Thermochemotherapy can reduce swollen
Oncocyte drug resistance, thermotherapy can obviously inhibit tumor cell multidrug resistance gene expression.At high operating temperatures, tumor cell membrane stream
Dynamic property increases, and the structure of film is caused to be destroyed with function.Ultra microstructure confirmation, cancer cell mitochondrial membrane, lysosome membrane and endoplasmic reticulum
Film destroys after thermotherapy, and due to a large amount of releases of lysosomal acid hydrolase, after birth is caused to rupture, and endochylema is excessive,
Cancer cell death.Thermotherapy can inhibit the DNA polymerases of tumour cell, connection enzymatic activity, lead to DNA, RNA dyssynthesis,
And by p53 rely on and it is non-dependent in a manner of cause Apoptosis.So being badly in need of a kind of temperature that can be accurately controlled dabbling drug now
The device of degree and the flow of perfusion.
Invention content
A kind of in order to overcome the deficiencies of the prior art, the utility model provides hyperthermic intraperitoneal perfusion chemotherapy device, can be accurate
The temperature and flow of liquid are controlled, and the water in heating water tank can be recycled, and will not pollute and waste, only to drug liquid tube
Liquid in road is heated, it is not necessary to heat the liquid in entire medicine liquid tank, more energy efficient environmental protection.
To achieve the goals above, the technical solution adopted in the utility model is:A kind of hyperthermic intraperitoneal perfusion chemotherapy device, packet
Heating mechanism, controller, medicine liquid tank and waste liquid tank are included, controller is electrically connected with heating mechanism, and the heating mechanism includes heating
Water tank, return and the liquor piping being placed in heating water tank are provided with inlet and outlet, loop pipe in heating water tank
The both ends in road are connected to inlet and outlet respectively, and heat conductor, heat transfer are equipped on the peripheral surface of the return
It is glued with ceramic heating plate on the peripheral surface of device, is additionally provided with first temperature probe on heat conductor, the one of the liquor piping
End is filled with liquid by drug-feeding tube and is connected, and the other end is connect by drug discharging tube with human abdominal cavity, and the medicine that gives up is filled through useless pencil and people
Body abdominal cavity connects, and second temperature probe and third temp probe are respectively arranged in heating water tank and drug discharging tube, and the first temperature is visited
Head, second temperature probe and third temp probe are electrically connected with the controller.
In above-mentioned technical proposal, controller refers to the wiring and change for changing main circuit or control circuit according to predetermined order
Resistance value enables device to control startup, speed governing, braking and reversely main of motor in circuit, is posted by program counter, instruction
Storage, command decoder, clock generator and operation and control device composition, it is publication order " policy-making body ", that is, completes association
The operation, including signal processing module, power module, transmission module etc. of entire computer system are commanded in reconciliation, in heating water tank
Fill water, water is formed into a loop by return and heating water tank, flow through return water heated by ceramic heating plate after
Heating water tank is returned to, the water in heating water tank is circulating-heating, and liquor piping impregnates the liquid reality for flowing through liquor piping in water
Existing heating water bath, environmental sanitation, the efficiency of heating surface is high, and the temperature controlling value of liquid, the liquid in medicine liquid tank are set by controller
By drug-feeding tube flow into liquor piping, it is heated after by drug discharging tube flow into human abdominal cavity, third temp probe will be in drug discharging tube
Fluid temperature signal reach controller, controller is judged, according to setting value correspond to power supply to ceramic heating plate made
Heat changes the temperature of water in heating water tank with this, and heat conductor is fastened with return, keeps and the liquid in return
Temperature is consistent, and first temperature probe and second temperature probe monitor the temperature of heat conductor and water respectively, only need to be to flowing through liquid
The liquid of pipeline is heated, it is not necessary to the medicine liquid heating in entire medicine liquid tank, and need not be avoided damage to liquid Repeat-heating
The pharmacological property of liquid, water is reusable, energy conservation and environmental protection, and temperature control is accurate.
As the further setting of the utility model, the return is compo pipe, and the heat conductor is alloy material
Material is made, and is divided into two panels up and down, is sleeved on the outside of return, is bolted and is installed in fastener type, the ceramics hair
Backing, which attaches, to be mounted on heat conductor.
In above-mentioned technical proposal, the thermal conduction effect of metal is high, avoids thermal loss, is divided into two panels up and down and passes through bolt shape
At removable cooperation, installation and replacement are very convenient, and the exterior contour of heat conductor is consistent with the exterior contour of return, and
Uniform fold on return, increase contact area, improve the efficiency of heating surface, ceramic heating plate have it is simple in structure, heating it is fast
Speed, temperature-compensating are fast, and power density is big, and heating temperature is high, and up to 500 DEG C or more, thermal efficiency height, homogeneous heating are energy saving, without bright
Fiery, safe to use, long lifespan, power attenuation is few, heater and air insulation, and element acid and alkali-resistance and other corrosive substances etc. are excellent
Point.
As the further setting of the utility model, water pump is provided on the return, the bottom of heating water tank is set
It is equipped with blender, blender is placed in the lower section of liquor piping, and the blender includes shaft and at least one setting in shaft
Paddle, paddle ovalisation, paddle is parallel with the bottom surface of heating water tank.
In above-mentioned technical proposal, pump is a kind of to increase the pressure of liquid or gas, is allowed to the machinery of transport flow, is
A kind of device being used for moving liquid, gas or specialized fluids medium, is the machinery to fluid work done, the effect of water pump is exactly
The water in heating water tank and return is set to flow, ceramic heating plate heating, stirring could be passed through by only flowing
The setting of device is so that the liquid in liquor piping is preferably heated in order to which the bath temperature in heating water tank is uniform, paddle at
Ellipse and the resistance for being for reducing blender fluid flow parallel with the bottom surface of heating water tank, heat utilization efficiency height.
As the further setting of the utility model, the liquor piping is spiral, is all provided on drug-feeding tube and useless pencil
It is equipped with peristaltic pump, peristaltic pump is electrically connected with the controller.
In above-mentioned technical proposal, liquor piping and can be prolonged to increase the contact area of liquid and water-bath
Flushing time of the long liquid in liquor piping keeps liquid fully heated, and convenient for being accurately controlled temperature, peristaltic pump can be controlled accurately
The flow of pharmacy liquid, peristaltic pump have many advantages, such as pollution-free, the high and low shearing force of precision, good airproof performance, have good from energy-absorbing
Power, idle running, can anti-backflow, safeguard simple, valveless and sealing element, there is two-way same flow conveying capacity, no liquid
Any part of pump will not be damaged in the case of dry run, the vacuum degree up to 98% can be generated, without valve, mechanical seal and
Stuffing seal, the factor also just revealed and safeguarded without these generations, can easily convey solid, liquid or gas-liquid mixed mutually flows
Body allows contained solid diameter in fluid to reach tubular element internal diameter 40%, can transport various sensitive special with grinding, burn into oxygen
Property material and various food etc., only hose is the component for needing to replace, and replacement operation is extremely simple, in addition to hose, is conveyed
Product is not contacted with any part, ensures the health of liquid, reduces the risk for the treatment of.
As the further setting of the utility model, the controller include display screen, switch button, setting button and
Alarm, setting button includes time button and temperature button.
In above-mentioned technical proposal, display screen is used for showing the monitor value of each setting value and each temp probe, facilitates doctor
Shield personnel operate and observation, the setting of alarm can be improved the safety used, ensure the therapeutic effect of patient.
Using the above scheme, it avoids Conventional thermal and treats the trouble that therapy needs manual hand manipulation, provide simultaneously
Higher precision and safety are that one kind can be widely used for clinical belly cavity tumor perfusion therapy, eliminate postoperative existing Asia and face
Bed lesion, the new instrument of complication caused by advanced malignant tumor ensure Curing circumstance and health.
The utility model is further described below in conjunction with the accompanying drawings.
Description of the drawings
Attached drawing 1 is the utility model specific embodiment appearance diagram;
Attached drawing 2 is the structural schematic diagram of the utility model specific embodiment heating mechanism;
Attached drawing 3 is the structure sectional view of the utility model specific embodiment return;
Attached drawing 4 is the structure top view of the utility model specific embodiment blender;
Attached drawing 5 is the structure diagram that csr controller is embodied in the utility model.
Specific implementation mode
Specific embodiment of the utility model is as shown in Figs. 1-5, a kind of hyperthermic intraperitoneal perfusion chemotherapy device, including heating mechanism
1, controller, medicine liquid tank 2 and waste liquid tank 3, controller are electrically connected with heating mechanism 1, and the heating mechanism 1 includes heating water tank
11, return 12 and the liquor piping 13 being placed in heating water tank 11 are provided with water inlet 111 and water outlet in heating water tank 11
Mouth 112, the both ends of return 12 are connected to water inlet 111 and water outlet 112 respectively, on the peripheral surface of the return 12
It is equipped with heat conductor 121, ceramic heating plate 122 is glued on the peripheral surface of heat conductor 121, is also set on heat conductor 121
It is equipped with first temperature probe 1211, one end of the liquor piping 13 fills 2 with liquid by drug-feeding tube 21 and connect, and the other end passes through
Drug discharging tube 22 is connect with human abdominal cavity, and useless medicine fills 3 and connect with human abdominal cavity by useless pencil 31, heating water tank 11 and drug discharging tube 22
On be respectively arranged with second temperature probe 113 and third temp probe 221, first temperature probe 1211, second temperature probe 113
It is electrically connected with the controller with third temp probe 221.Controller refers to changing main circuit or control circuit according to predetermined order
Wiring and change resistance value in circuit and enable device to control the startup of motor, speed governing, braking and reversely main, by program meter
Number device, command register, command decoder, clock generator and operation and control device composition, it is publication order " decision machine
Structure ", that is, complete the operation for coordinating and commanding entire computer system, including signal processing module, power module, transmission module
Deng filling water in heating water tank 11, water is formed into a loop by return 12 and heating water tank 11, flows through the water of return 12
Heating water tank 11 is returned to after being heated by ceramic heating plate 122, the water in heating water tank 11 is circulating-heating, and liquor piping 13 soaks
It ducks in drink, the liquid for flowing through liquor piping 13 realizes heating water bath, and environmental sanitation, the efficiency of heating surface is high, is set by controller
The temperature controlling value of liquid, the liquid in medicine liquid tank 2 flow into liquor piping 13 by drug-feeding tube 21, pass through drug discharging tube after heated
22 flow into human abdominal cavity, and the fluid temperature signal in drug discharging tube 22 is reached controller by third temp probe 221, and controller carries out
Judge, is corresponded to according to setting value and heated to the power supply of ceramic heating plate 122, change the temperature of water in heating water tank 11 with this
Degree, heat conductor 121 are fastened with return 12, keep, first temperature probe consistent with the fluid temperature in return 12
1211 and second temperature probe 113 monitor the temperature of heat conductor 121 and water respectively, only need to be to flowing through the liquid of liquor piping 13
It is heated, it is not necessary to the medicine liquid heating in entire medicine liquid tank 2, and the medicine of liquid need not be avoided damage to liquid Repeat-heating
Property, water is reusable, energy conservation and environmental protection, and temperature control is accurate.
Above-mentioned return 12 is compo pipe, and the heat conductor 121 is made of alloy material, is divided into two panels up and down, set
It mounted in the outside of return 12, is bolted and is installed in fastener type, the ceramic heating plate 122, which attaches, is mounted on heat biography
It leads on device 121.The thermal conduction effect of metal is high, avoids thermal loss, is divided into two panels up and down and forms removable cooperation by bolt,
Installation and replacement are very convenient, and the exterior contour of heat conductor 121 is consistent with the exterior contour of return 12, and uniform fold
On return 12, increasing contact area, improves the efficiency of heating surface, ceramic heating plate 122 has simple in structure, heating is rapid,
Temperature-compensating is fast, and power density is big, and heating temperature is high, and up to 500 DEG C or more, thermal efficiency height, homogeneous heating are energy saving, the flames of anger,
The advantages that safe to use, long lifespan, power attenuation is few, heater and air insulation, element acid and alkali-resistance and other corrosive substances.
Water pump 123 is provided on above-mentioned return 12, the bottom of heating water tank 11 is provided with blender 114, blender
114 are placed in the lower section of liquor piping 13, and the blender 114 includes shaft 1141 and at least one is arranged in shaft 1141
Paddle 1142,1142 ovalisation of paddle, paddle 1142 are parallel with the bottom surface of heating water tank 11.Pump, it is a kind of increasing
The pressure of liquid feeding body or gas is allowed to the machinery of transport flow, be it is a kind of be used for move liquid, gas or specialized fluids medium
Device is the machinery to fluid work done, and the effect of water pump 123 is exactly that the water in heating water tank 11 and return 12 is enable to flow
It moves up, the heating of ceramic heating plate 122 could be passed through by only flowing, and the setting of blender 114 is for heating water tank 11
Interior bath temperature is uniform, and the liquid in liquor piping 13 is made preferably to be heated, 1142 ovalisation of paddle and with heating water
The parallel resistance for being for reducing 114 fluid flow of blender in the bottom surface of case 11, heat utilization efficiency are high.
Above-mentioned liquor piping 13 is spiral, and peristaltic pump 211,311 is both provided on drug-feeding tube 21 and useless pencil 31, wriggles
Pump 211,311 is electrically connected with the controller.Liquor piping 13 is helically to increase the contact area of liquid and water-bath, and energy
Extend flushing time of the liquid in liquor piping 13, keeps liquid fully heated, convenient for being accurately controlled temperature, peristaltic pump 211,
311 can accurately control the flow of liquid, and peristaltic pump 211,311 has pollution-free, the high and low shearing force of precision, good airproof performance etc. excellent
Point, has a good suction capacity, idle running, can anti-backflow, safeguard simple, valveless and sealing element, have two-way same
Flow conveying capacity will not damage any part of pump in the case of no liquid dry run, can generate the vacuum up to 98%
Degree, without valve, mechanical seal and stuffing seal, the factor also just revealed and safeguarded without these generations can be easily defeated
Solid, liquid or gas-liquid mixed phase fluid are sent, allows contained solid diameter in fluid to reach tubular element internal diameter 40%, can transport various
With grinding, the material of burn into oxygen sensitivity characteristic and various food etc., only hose is the component for needing to replace, replacement operation pole
To be simple, in addition to hose, institute's conveying products are not contacted with any part, ensure the health of liquid, reduce the risk for the treatment of.
Above controller includes display screen, switch button, setting button and alarm, and setting button includes time button
And temperature button.Display screen is used for showing the monitor value of each setting value and each temp probe, facilitate medical staff's operation and
Observation, the safety used can be improved in the setting of alarm, ensures the therapeutic effect of patient, alarm signal source controller,
Feedback signal will be generated when the temperature of digital display meter real-time detection reaches preset alarm temperature to controller, controller then drives
Alarm equipment alarm, alarm threshold value problem can be adjusted as needed by digital display meter, avoid causing to anticipate to user to greatest extent
Outer damage.
There are high temperature to be easy oxidation, short life for B alloy wire heating element, has that open fire is dangerous, the thermal efficiency is low, heating is uneven
The shortcomings of even, and generally only 200 DEG C or so of the heating temperature of PTC heating elements, heating temperature are then universal higher than 120 DEG C
Using lead orthoplumbate, just belong to the product being eliminated since lead tolerance is big.High temperature fire ceramic heating plate (MCH) is directly to exist
On AL2O3 aluminium oxide ceramics green compact after printed resistor slurry, fire at a high temperature of 1600 DEG C or so, then again through electrode, draw
After line processing, low-temperature heating element is another after heating alloy, PTC heating elements in a new generation produced
Replacement new product, be widely used in daily life, industrial or agricultural technology, communication, medical treatment, environmental protection, etc. the crowd of low-temperature heat in each needs
It is multi-field.In terms of home-use electric heating appliance:Such as small-sized warm air warmer, hair dryer, dryer, warming machine, changes in temperature mobile phone, drying
Device, electric heating clamping plate, electric iron, electric iron, heater of hair straightener, curly hair hair iron, electronic heat-insulating bottle, thermal insulation cabinet, electric-heating cooking utensil, sitting toilet pottery
Porcelain heater, water heater etc. dry construction equipment, electric heating paster, water oil and Acid-base liquid heater in industrial aspect such as industry,
Such as small, dedicated quartz crystal device thermostat in terms of electronics industry, such as infrared physiotherapy equipment, intravenous fluid heats in terms of medical treatment
Device etc..
The utility model is not limited to above-mentioned specific implementation mode, and persons skilled in the art are according to the utility model public affairs
The content opened, may be used other a variety of specific implementation modes implement it is the utility model or it is every use the utility model
Design structure and thinking, do simple change or change, both fall within the scope of protection of the utility model.
Claims (5)
1. a kind of hyperthermic intraperitoneal perfusion chemotherapy device, including heating mechanism, controller, medicine liquid tank and waste liquid tank, controller and heating
Mechanism is electrically connected, it is characterised in that:The heating mechanism includes heating water tank, return and the liquid being placed in heating water tank
Pipeline is provided with inlet and outlet in heating water tank, and the both ends of return are connected to inlet and outlet respectively, institute
It states and is equipped with heat conductor on the peripheral surface of return, ceramic heating plate, heat transfer are glued on the peripheral surface of heat conductor
First temperature probe is additionally provided on device, one end of the liquor piping is filled by drug-feeding tube and liquid to be connected, and the other end passes through
Drug discharging tube is connect with human abdominal cavity, and useless medicine, which is filled, to be connect by useless pencil with human abdominal cavity, is set respectively on heating water tank and drug discharging tube
Be equipped with second temperature probe and third temp probe, first temperature probe, second temperature probe and third temp probe with control
Device electrical connection processed.
2. hyperthermic intraperitoneal perfusion chemotherapy device according to claim 1, it is characterised in that:The return is compo pipe,
The heat conductor is made of alloy material, is divided into two panels up and down, is sleeved on the outside of return, is bolted in button
Part formula is installed, and the ceramic heating plate, which attaches, to be mounted on heat conductor.
3. hyperthermic intraperitoneal perfusion chemotherapy device according to claim 1 or 2, it is characterised in that:It is arranged on the return
There are water pump, the bottom of heating water tank to be provided with blender, blender is placed in the lower section of liquor piping, and the blender includes shaft
With at least one paddle being arranged in shaft, paddle ovalisation, paddle is parallel with the bottom surface of heating water tank.
4. hyperthermic intraperitoneal perfusion chemotherapy device according to claim 1 or 2, it is characterised in that:The liquor piping is at spiral
It is both provided with peristaltic pump on shape, drug-feeding tube and useless pencil, peristaltic pump is electrically connected with the controller.
5. hyperthermic intraperitoneal perfusion chemotherapy device according to claim 4, it is characterised in that:The controller includes display
Screen, switch button, setting button and alarm, setting button includes time button and temperature button.
Priority Applications (1)
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CN201720371965.0U CN207837719U (en) | 2017-04-07 | 2017-04-07 | Hyperthermic intraperitoneal perfusion chemotherapy device |
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CN201720371965.0U CN207837719U (en) | 2017-04-07 | 2017-04-07 | Hyperthermic intraperitoneal perfusion chemotherapy device |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109893334A (en) * | 2019-04-29 | 2019-06-18 | 河南中医药大学 | Abdominal thermal infusion chemotherapy device |
CN110811524A (en) * | 2019-11-08 | 2020-02-21 | 武汉佑康科技有限公司 | Visual thermotherapy device |
CN110885800A (en) * | 2019-12-11 | 2020-03-17 | 宁波酶赛生物工程有限公司 | Heat treatment clarification method of industrial enzyme liquid |
CN112932945A (en) * | 2021-03-31 | 2021-06-11 | 温州市中心医院 | Traditional Chinese medicine thermotherapy device for medical oncology |
-
2017
- 2017-04-07 CN CN201720371965.0U patent/CN207837719U/en not_active Expired - Fee Related
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109893334A (en) * | 2019-04-29 | 2019-06-18 | 河南中医药大学 | Abdominal thermal infusion chemotherapy device |
CN109893334B (en) * | 2019-04-29 | 2020-12-25 | 河南中医药大学 | Abdominal cavity heat perfusion chemotherapy device |
CN110811524A (en) * | 2019-11-08 | 2020-02-21 | 武汉佑康科技有限公司 | Visual thermotherapy device |
CN110885800A (en) * | 2019-12-11 | 2020-03-17 | 宁波酶赛生物工程有限公司 | Heat treatment clarification method of industrial enzyme liquid |
CN112932945A (en) * | 2021-03-31 | 2021-06-11 | 温州市中心医院 | Traditional Chinese medicine thermotherapy device for medical oncology |
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GR01 | Patent grant | ||
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CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180911 Termination date: 20190407 |
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CF01 | Termination of patent right due to non-payment of annual fee |