CN207832811U - A kind of incubation disk device of chemical illumination immunity analysis instrument - Google Patents
A kind of incubation disk device of chemical illumination immunity analysis instrument Download PDFInfo
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- CN207832811U CN207832811U CN201820245141.3U CN201820245141U CN207832811U CN 207832811 U CN207832811 U CN 207832811U CN 201820245141 U CN201820245141 U CN 201820245141U CN 207832811 U CN207832811 U CN 207832811U
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Abstract
The utility model is related to technical field of immunoassay more particularly to a kind of incubation disk devices of chemical illumination immunity analysis instrument.It includes upper shell, the lower housing being interlocked with the upper shell, with the track switching mechanism on the upper shell, rotatable load cup disk is equipped in the lower housing, the load cup disk offers multiple reaction cup loading hole successively along its rotation direction, the part for being located at the lower section for carrying cup disk in the lower housing is equipped with incubation slot corresponding with the reaction cup loading hole, reaction cup enters through the reaction cup loading hole in the incubation slot, the incubation slot includes multiple groove bodies, the track switching mechanism between multiple groove bodies for switching over the reaction cup.Incubation, cleaning and detection are integrated in one by the utility model, overall structure simple and compact, easy to use, reduce experimental implementation, save experimental period, improve conventional efficient.
Description
Technical field
The utility model is related to technical field of immunoassay more particularly to a kind of incubation disks of chemical illumination immunity analysis instrument
Device.
Background technology
Chemiluminescence immunoassay is to be combined chemical reaction system with immune system, for detecting antigen or resisting
Body.With chemiluminescent substance labelled antigen and antibody, the specificity of existing immune response, and the Gao Min with chemiluminescence reaction
Perception, operating method is simple and convenient, reproducible, pollution-free, and is widely applied clinically.
It is to realize immune biochemical in the way of Automatic Control out of the human body due to Full-automatic chemiluminescence immune detector
Reaction process, and quantitative analysis is detected to reaction process result.It is Full-automatic chemiluminescence immune detector core to be incubated disk
Heart unit is incubated disk constant temperature and just can guarantee that chemiluminescence immunoassay process is normal.
Multiple hole channel-shaped for placing response cup are arranged on being incubated disk and are incubated for existing Full-automatic chemiluminescence apparatus device
Position.During incubation, the mode of machinery crawl is usually taken in switching of the reaction cup between different incubation positions, not only can not
Efficiently realize being switched fast between different incubation positions, but also there are the risks that reaction cup can not accurately in place.
Existing Full-automatic chemiluminescence apparatus device is being added using magnetic particle as reaction carriers into reaction cup
After body fluid sample to be analyzed, then the magnetism containing the microscale/nanoscale for being adsorbed with antigen or antibody is added into reaction cup
The reaction reagent of particle.Magnetic particle is suspended in reaction reagent, after the completion of the incubation reaction of sample and reagent, it is necessary to clear
It washes to remove unreacted sample and reagent, the compound using magnetic particle as solid phase carrier is retained only in reaction cup.
But existing Full-automatic chemiluminescence apparatus device, it is only to load cup to be incubated disk design, is fitted without detection machine
Structure or wiper mechanism, when need execute detection or cleaning etc. functions when, it is necessary to by reaction cup transfer or grab be incubated disk it
In other outer detections or cleaning positions, experimental period is expended, working efficiency is reduced.
And the existing reaction cup mode of heating majority for being incubated disk uses air transmitted mode, is incubated disk and holds for constant temperature space
Device heats reaction cup by air bath, the disadvantage is that reaction cup heating rate is slow, incubation disk thermal capacitance is small, is easy by outer
Boundary's environment influences.In addition, reaction cup before reaction cup use, is usually placed on external room temperature space by existing incubation disk,
It when using reaction cup, needs to be carried out at the same time heating to reaction cup and reagent, the reaction cup heating-up time is long, leads to reagent reaction effect
Rate is low.
Utility model content
(1) technical problems to be solved
Switch difficult technological deficiency between multiple incubation positions for existing reaction cup, the utility model is intended to carry
For a kind of incubation disk device of compact-sized, easy to use chemical illumination immunity analysis instrument, to solve existing incubation disk device
Ineffective technical problem.
(2) technical solution
In order to solve the above-mentioned technical problem, the utility model provides a kind of incubation disk dress of chemical illumination immunity analysis instrument
It sets comprising upper shell, the lower housing being interlocked with the upper shell, and the track switching mechanism on the upper shell,
Rotatable load cup disk is equipped in the lower housing, the load cup disk offers multiple reaction cups along its rotation direction and loads successively
Hole, the part that the lower section for carrying cup disk is located in the lower housing are equipped with incubation slot corresponding with the reaction cup loading hole,
Reaction cup enters through the reaction cup loading hole in the incubation slot, and the incubation slot includes multiple groove bodies, the track switching
Mechanism between multiple groove bodies for switching over the reaction cup.
Further, the disk device that is incubated further includes the wiper mechanism for carrying out magnetic wash to the reaction cup,
The wiper mechanism includes the cleaning pin hole for wearing cleaning needle, and is equipped with the magnet mounting base of multiple magnet, described
Cleaning pin hole is opened in the upper shell, and is oppositely arranged up and down with the reaction cup so that the cleaning needle stretch into it is described anti-
It answers in cup, the magnet mounting base is set to the most inner side of the incubation slot, and the magnet is detached for the magnetic wash, and with
The reaction cup is oppositely arranged, and multiple magnet are arranged in order along the rotation direction for carrying cup disk, are arranged such so that anti-
Answer cup after magnet mounting base, the magnetic particle in reaction cup is attached on the inside of wall of cup, to the subsequent cleaning behaviour that is more convenient for
Make, improves cleaning efficiency.The liquid or liquid is injected into reaction cup that the cleaning needle is used in abstraction reaction cup.
Further, the wiper mechanism is multiple, and multiple wiper mechanisms are along the rotation direction for carrying cup disk
Interval setting.
Further, the wiper mechanism further includes the cleaning needle guide pad set on the upper shell, and the cleaning needle can
It is oriented to, is inserted vertically into the cleaning pin hole by the cleaning needle guide pad.The setting of the cleaning needle guide pad, makes cleaning needle
It is more accurately inserted into cleaning pin hole, to improve work efficiency.
Preferably, the cleaning pin hole is multiple.
Further, the upper shell offers the observation window for observing response cup mobile status；
And/or the upper shell offers the temperature detection hole that sample incubation temperature is detected convenient for temperature probe；
And/or the upper shell offers loading reaction rim of a cup, the reaction cup enters institute through loading reaction rim of a cup
State reaction cup loading hole；
And/or the lower housing is additionally provided with testing agency's mounting base for installing optical de-tection means；The incubation slot
For being incubated to the sample in reaction cup, the optical de-tection means are then used for the sample after incubation (i.e. with magnetic micro-
Compound of the grain as solid phase carrier) carry out optical detection.
Further, the upper shell lower surface offers the movement of the reaction cup for being oriented to the movement of reaction cup
Guide groove, to improve the stability of reaction cup movement.
Further, the incubation slot includes preparatory response cup slot, the first incubation slot and the second incubation slot, and the preparation is anti-
The vertical view of a glass slot, the first incubation slot and the second incubation slot is answered to see in a ring, and successively from the inner ring of the lower housing to outer ring
Setting；It is in inverted trapezoidal that the section of the preparatory response cup slot, the first incubation slot and the second incubation slot, which is seen, in order to quickly will be hot
Amount is transmitted in reaction cup；The preparatory response cup slot is used in reaction cup before use, being preheated to reaction cup；Described first
Incubation slot is used for reacting between sample and reagent；Second incubation slot can be used for reacting between sample and reagent, but main
When being used for using one-step method, in carrying cup disk rotation process, reaction cup is avoided into wiper mechanism；
The preparatory response cup slot, the first incubation slot and the second incubation slot partly overlap successively, and are opened up in overlapping
There is incubation slot switching port；
The track switching mechanism includes hood, incubation slot switch head and lead screw motor, and the hood and lead screw are electric
Machine is set to the upper shell, and the incubation slot switch head is set on the screw rod of the lead screw motor, and is located at the hood
Interior, the bottom end of the incubation slot switch head is configured with card slot, and the size of the card slot and the top of the reaction cup match, with
The top of the reaction cup is set to be stuck in the card slot, thus in the incubation slot switching port under the driving of the lead screw motor
Place switches over the reaction cup between the preparatory response cup slot, the first incubation slot and the second incubation slot.
Further, the space moved radially for the reaction cup is equipped in the reaction cup loading hole, to ensure to react
When cup switches between preparatory response cup slot, the first incubation slot and the second incubation slot, the reaction cup has enough movements
Space.Described move radially refers to that the radial direction along the preparatory response cup slot, the first incubation slot or the second incubation slot is moved
It is dynamic.
Preferably, the upper shell offers track switching mechanism mounting hole, and the hood is covered in the track and cuts
On converting mechanism mounting hole, and it is oppositely arranged with the incubation slot switching port.Preferably, the movement of the screw rod is to move radially.
Further, the outer ring of first incubation slot and the second incubation slot offers the temperature for installing heating mechanism
Spend heating tank.The heating mechanism is for heating incubation reaction, to ensure luminescence reagent reaction temperature in detection process
Consistency.
Further, the incubation disk device further includes mixing mechanism, the mixing mechanism include circulator and be set to institute
The rotary drive motor below circulator is stated, the top of the circulator and the bottom end of the reaction cup are mutually amplexiformed, the rotation
The bottom end of device is connected with the shaft of the rotary drive motor, and the rotary drive motor is set in the lower housing.It is described
Circulator is rotated under the driving of the rotary drive motor, to drive the reaction cup of top to be shaken or rotated,
And then the sample in reaction cup is made to be uniformly mixed with reagent, it is ensured that sample is fully reacted with reagent.
Preferably, the circulator is centering type circulator, and top center construction is fluted.
Preferably, the mixing mechanism is not more than 5, and is spaced setting, to ensure that reaction cup realizes Fixed Time Interval
Timing mixing.
Preferably, drag reduction frictional layer, the drag reduction frictional layer are equipped between the circumferential outer rim and lower housing for carrying cup disk
Surface is smooth, can mitigate frictional resistance when carrying the rotation of cup disk.
Preferably, the disk device that is incubated further includes abandoning cup mechanism set on the upper shell, and the cup mechanism of abandoning includes
Abandon a glass switch, driving motor, optoelectronic switch and shading shell, the lower housing offers cup aperture, it is described fall cup aperture as abandoning
The outlet of cup, connection are extraneous；A glass position is abandoned when reaction cup to be abandoned is moved to, glass switch is abandoned in driving motor driving will be anti-
Cup is answered to be moved in cup aperture.
(3) advantageous effect
The above-mentioned technical proposal of the utility model has the advantages that：
1, the incubation disk device of the utility model is provided with track switching mechanism, can be achieved under the driving of lead screw motor anti-
Answer switching of the cup between multiple groove bodies (i.e. preparatory response cup slot, the first incubation slot and the second incubation slot) of incubation slot.Therefore,
Relative to existing incubation disk device, the incubation disk device of the utility model is not necessarily to can be realized instead by the mode of machinery crawl
Switching of the cup between different incubation slots is answered, the degree of automation higher, working efficiency higher is more time saving and energy saving, and improves
Structural stability reduces the risk that reaction cup can not accurately in place.2, the incubation disk device of the utility model is equipped with cleaning machine
Structure, the wiper mechanism carry out magnetic wash work using magnetic wash separation principle：In cleaning, cup disk is carried by rotation,
So that reaction cup to be cleaned is gone to below cleaning pin hole, the magnet being oppositely arranged with the reaction cup is made by magnetic fields
It obtains magnetic particle to move to magnet direction, be stopped by the wall of cup of reaction cup in motion process, magnetic particle is eventually adhering to instead
Answer cup on the inside of the wall of cup of near magnet side；At this point, cleaning needle is deep into reaction cup bottom, including liquid-like in reaction cup
Originally and all liq including unreacted reagent is taken out；And magnetic particle solid phase carrier is due to being adsorbed on wall of cup, it will not
It is pulled away；Then, wiper mechanism injects cleaning solution into reaction cup by cleaning needle again, to magnetic microsphere as solid phase carrier
Compound is cleaned；Cleaning solution is extracted out again later, after multiplicating, completes entire cleaning process.
The incubation disk device of the utility model, lower housing are offered along the rotation direction for carrying cup disk for placing response cup
Incubation slot, the sample in the reaction cup carries out incubation reaction, the magnet peace of the wiper mechanism with reagent in incubation slot
Cartridge seat is in the inside of incubation slot, and the magnet is oppositely arranged with reaction cup, and multiple magnet are successively along the load cup disk
Rotation direction arranged, this organic matching relationship of the incubation slot and wiper mechanism so that incubation reaction can with it is clear
It washes and is integrated in one.Moreover, the incubation disk device of the utility model is additionally provided with testing agency's mounting base, the testing agency simultaneously
Mounting base can be used to install optical de-tection means, to carry out optics inspection to the compound using magnetic particle as solid phase carrier
It surveys.
It can be seen that incubation, cleaning and detection are integrated in one by the incubation disk device of the utility model, overall structure letter
It is single compact, it is easy to use, when needing to execute cleaning or detection function, disk device is incubated without transferring or grabbing reaction cup
Except cleaning or test position on, relative to it is existing with cleaning and testing agency be separated incubation disk device, this practicality
Novel incubation disk device reduces experimental implementation, saves experimental period, improves conventional efficient.
3, the incubation disk device of the utility model sets incubation slot to multigroup annular back taper trough body structure, compared to existing
The poroid incubation position having, reaction cup heating effect in annular trough body is more preferable, and reaction rate is faster.More specifically,
Preparatory response cup slot can be in reaction cup before use, being preheated to reaction cup, therefore without using preceding single to reaction cup progress
Solely heating, to reduce heating and the reaction time of sample and reagent, accelerates reaction process, improves the effect of incubation reaction
Rate.The temperature heating tank of a ring shape is offered in the outer ring of the first incubation slot and the second incubation slot, is pacified in temperature heating tank
Heating mechanism is filled, for being heated to entire incubation reaction.So set, both having overcome the mode of heating of existing air bath
In, reaction cup heating rate is slow, the defect that is easily influenced by ambient temperature, and can make incubating in reaction cup at different location
It educates that reaction temperature is consistent, to improve the temperature uniformity of incubation reaction, ensure that testing result is to examine at a constant temperature
It surveys, reduces influence of the environment to detection, improve the anti-interference ability of detecting instrument, and then reduce experimental error, improve
The accuracy of experimental result.
4, the incubation disk device of the utility model is also further provided with mixing mechanism, and the circulator is in rotation driving electricity
Rotated under the driving of machine, to drive the reaction cup of top to be shaken or rotated, and then make sample in reaction cup with
Reagent is uniformly mixed, it is ensured that sample is fully reacted with reagent, has further speeded up reaction process, reduces the reaction time, is carried
High reaction efficiency；And mixing mechanism is purely mechanic mixing, to reduce labor intensity.
Description of the drawings
Fig. 1 is the structural schematic diagram of the incubation disk device of chemical illumination immunity analysis instrument described in the utility model embodiment；
Fig. 2 is the structural schematic diagram of upper shell described in the utility model embodiment；
Fig. 3 is the structural schematic diagram that cup disk is carried described in the utility model embodiment；
Fig. 4 is the structural schematic diagram of lower housing described in the utility model embodiment；
Fig. 5 is the structural schematic diagram of testing agency's mounting base of lower housing reverse side setting described in the utility model embodiment；
Fig. 6 is the structural schematic diagram of magnet mounting base described in the utility model embodiment；
Fig. 7 is the structural schematic diagram of track switching mechanism described in the utility model embodiment；
Fig. 8 is the structural schematic diagram of mixing mechanism described in the utility model embodiment；
Fig. 9 is the structural schematic diagram that cup mechanism is abandoned described in the utility model embodiment；
Wherein, 100, upper shell；110, observation window；120, temperature detection hole；130, reaction rim of a cup is loaded；140, cleaning needle
Hole；150, cleaning needle guide pad；160, track switching mechanism mounting hole；170, reaction cup mobile guide groove；200, lower housing；
210, preparatory response cup slot；210-1, the first incubation slot；210-2, the second incubation slot；210-3, incubation slot switching port；220, warm
Spend heating tank；230, drag reduction frictional layer；240, temperature sensor fixing hole；241, mixing mechanism mounting base；242, fluted disc motor
Mounting base；243, testing agency's mounting base；250, fall cup aperture；260, wiper mechanism；270, magnet mounting base；270-1, magnet；
280, heating film；300, cup disk is carried；301, reaction cup loading hole；302, fluted disc location hole；400, track switching mechanism；410, it incubates
Educate slot switch head；420, lead screw motor；430, hood；440, the first optoelectronic switch；441, photoelectricity catch；442, screw rod；
443, card slot；500, mixing mechanism；510, circulator；520, rotary drive motor；600, cup mechanism is abandoned；610, cup switching is abandoned
Device；620, driving motor；621, the second optoelectronic switch；630, shading shell；700, support base；710, bottom plate；720, insulating layer.
Specific implementation mode
The embodiment of the utility model is described in further detail with reference to the accompanying drawings and examples.Following embodiment
For illustrating the utility model, but cannot be used for limiting the scope of the utility model.
In the description of the present invention, unless otherwise indicated, the meaning of " plurality " is two or more；Term
The orientation of the instructions such as "upper", "lower", "left", "right", "inner", "outside", " top ", " bottom end ", " head ", " tail portion " or position are closed
System is to be based on the orientation or positional relationship shown in the drawings, and is merely for convenience of describing the present invention and simplifying the description, rather than
Indicate or imply that signified device or element must have a particular orientation, with specific azimuth configuration and operation, therefore cannot
It is construed as a limitation of the present invention.In addition, term " first ", " second ", " third " etc. are used for description purposes only, and cannot
It is interpreted as indicating or implying relative importance.
In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " phase
Even ", " connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or be integrally connected；It can
Can also be electrical connection to be mechanical connection；It can be directly connected, it can also be indirectly connected through an intermediary.For this
For the those of ordinary skill in field, the concrete meaning of above-mentioned term in the present invention can be understood depending on concrete condition.
As shown in Fig. 1~Fig. 9, a kind of incubation disk device of chemical illumination immunity analysis instrument is present embodiments provided, is wrapped
Include bottom plate 710, support base 700, upper shell 100, the lower housing 200 being interlocked with upper shell 100, on upper shell 100
Track switching mechanism 400, and the wiper mechanism 260 for carrying out magnetic wash to reaction cup.
Lower housing 200 is fixed on by support base 700 on bottom plate 710, and 700 not heat conduction of support base.It is set in lower housing 200
There is rotatable load cup disk 300, it is black to carry 300 surface of cup disk, carries and offers no less than 200 reaction cups on cup disk 300
Hole 301 is carried, multiple reaction cup loading hole 301 are arranged in order along the rotation direction for carrying cup disk 300, and lower housing 200 is along load cup disk 300
Rotation direction offer the incubation slot for placing response cup, reaction cup loading hole 301 and incubation slot are oppositely arranged up and down, with
Make reaction cup can reacted cup loading hole 301 enter in incubation slot, incubation slot includes multiple groove bodies, and track switching mechanism 400 is used
It is switched between multiple groove bodies in by reaction cup.The outer rim of lower housing 200 is additionally provided with for installing optical detector
Testing agency's mounting base 243 of structure；For being incubated to the sample in reaction cup, optical de-tection means are used for incubating incubation slot
Sample (i.e. using magnetic particle as the compound of solid phase carrier) after educating carries out optical detection.
Specifically, wiper mechanism 260 includes the cleaning pin hole 140 for wearing cleaning needle, and multiple magnetic are installed
The magnet mounting base 270 of iron 270-1, cleaning pin hole 140 is opened in upper shell 100, and is oppositely arranged up and down with reaction cup, so that
Cleaning needle stretches into reaction cup, and magnet mounting base 270 is set to the most inner side in lower housing 200 and positioned at incubation slot, magnet 270-1
Detach, and be oppositely arranged with reaction cup for magnetic wash, multiple magnet 270-1 successively along carry the rotation direction of cup disk 300 into
Row arrangement.
In the present embodiment, wiper mechanism 260 is multiple, and multiple wiper mechanisms 260 are between the rotation direction for carrying cup disk 300
Every setting.Moreover, multiple magnet 270-1 are arranged in order in the rotation direction for carrying cup disk 300；It is arranged such so that reaction cup
After magnet mounting base 270, magnetic particle in reaction cup is stepped from high to low to be attached on the inside of wall of cup, to more just
In subsequent cleaning operation, cleaning efficiency is improved.
Further, wiper mechanism 260 further includes the cleaning needle guide pad 150 set on upper shell 100, and cleaning needle can be clear
It washes under the guiding of needle guide pad 150, is inserted perpendicularly into cleaning pin hole 140.The setting of cleaning needle guide pad 150 makes cleaning needle more
It is accurately inserted into cleaning pin hole 140, to improve work efficiency.The cleaning needle of each wiper mechanism 260 in the present embodiment
Hole 140 can be multiple.
Further, upper shell 100 offers the observation window 110 for observing response cup mobile status；Upper shell 100 is opened
Equipped with the temperature detection hole 120 for detecting sample incubation temperature convenient for temperature probe；Upper shell 100 offers loading reaction rim of a cup
130, the loaded reaction rim of a cup 130 of reaction cup enters reaction cup loading hole 301.100 lower surface of upper shell is offered for anti-
The reaction cup mobile guide groove 170 that the movement of cup is oriented to is answered, to improve the stability of reaction cup movement.
It is incubated specifically, multiple groove bodies of incubation slot are respectively preparatory response cup slot 210, the first incubation slot 210-1 and second
Slot 210-2 is educated, the vertical view of preparatory response cup slot 210, the first incubation slot 210-1 and the second incubation slot 210-2 is seen in a ring, and
It is set gradually from the inner ring of lower housing 200 to outer ring；Preparatory response cup slot 210, the first incubation slot 210-1 and the second incubation slot
It is in inverted trapezoidal that the section of 210-2, which is seen, in order to quickly conduct heat in reaction cup；Preparatory response cup slot 210 is used for
Reaction cup is before use, preheat reaction cup；First incubation slot 210-1 is used for reacting between sample and reagent；Second incubates
When educating slot 210-2 and can be used for reacting between sample and reagent, but being used primarily for one-step method, rotated carrying cup disk 300
Reaction cup is avoided wiper mechanism 260 by Cheng Zhong；Preparatory response cup slot 210, the first incubation slot 210-1 and the second incubation slot 210-2
It partly overlaps successively, and incubation slot switching port 210-3 is offered in overlapping.
Track switching mechanism 400 includes hood 430, incubation slot switch head 410, lead screw motor 420, the first optoelectronic switch
440 and photoelectricity catch 441, hood 430 and lead screw motor 420 are set to upper shell 100, and incubation slot switch head 410 is set to silk
On the screw rod 442 of bar motor 420, and in hood 430, the bottom end of incubation slot switch head 410 is configured with card slot 443, card
The size of slot 443 and the top of reaction cup match, so that the top of reaction cup is stuck in card slot 443, in lead screw motor
Under 420 driving at incubation slot switching port 210-3 by reaction cup in preparatory response cup slot 210, the first incubation slot 210-1 and
It is switched between two incubation slot 210-2.In the present embodiment, incubation slot switch head 410 can be unidirectional incubation slot switch head 410,
It is alternatively two-way incubation slot switch head 410.
Further, the space moved radially for reaction cup is equipped in reaction cup loading hole 301, to ensure reaction cup pre-
When being switched between standby reaction cup slot 210, the first incubation slot 210-1 and the second incubation slot 210-2, reaction cup has enough shiftings
Dynamic space.
Preferably, upper shell 100 offers track switching mechanism mounting hole 160, and hood 430 is covered in track switching machine
On structure mounting hole 160, and it is oppositely arranged with incubation slot switching port 210-3.The movement of screw rod 442 is to move radially, anti-to ensure
Answer radial switching of the cup in different incubation slots.The outer ring of first incubation slot 210-1 and the second incubation slot 210-2 open up useful
In the temperature heating tank 220 of installation heating mechanism.
In addition, the lower housing 200 of the present embodiment, outside, bottom, centre, inside, which are sticked, heating film 280, heating
There is insulating layer 720 in 280 outside of film, to make incubation reaction more steadily carry out.
Further, the incubation disk device of the present embodiment further includes mixing mechanism 500, and mixing mechanism 500 includes circulator
510 and the rotary drive motor 520 set on the lower section of circulator 510, the top of circulator 510 mutually amplexiformed with the bottom end of reaction cup,
The bottom end of circulator 510 is connected with the shaft of rotary drive motor 520, and rotary drive motor 520 is installed by mixing mechanism
Seat 241 is set in lower housing 200.Circulator 510 is rotated under the driving of rotary drive motor 520, to drive top
Reaction cup shaken or rotated, and then the sample in reaction cup is made to be uniformly mixed with reagent, it is ensured that sample is filled with reagent
Divide reaction.
In the present embodiment, circulator 510 is centering type circulator 510, and top center construction is fluted.Mixing mechanism
500 are not more than 5, and are spaced setting, to ensure that reaction cup realizes Fixed Time Interval timing mixing.
In the present embodiment, it is equipped with drag reduction frictional layer 230 between the circumferential outer rim and lower housing 200 of load cup disk 300, drag reduction rubs
230 surface of wiping layer is smooth, can mitigate the frictional resistance carried when cup disk 300 rotates.
Preferably, it further includes abandoning cup mechanism 600 set on upper shell 100 to be incubated disk device, and it includes abandoning cup to abandon cup mechanism 600
Switch 610, driving motor 620, the second optoelectronic switch 621 and shading shell 630, lower housing 200 offer cup aperture 250, fall
For cup aperture 250 as the outlet for abandoning cup, connection is extraneous；A glass position is abandoned when reaction cup to be abandoned is moved to, driving motor 620 drives
It is dynamic to abandon glass switch 610 reaction cup is moved in cup aperture 250.
In the present embodiment, referring to Fig. 3, carries and be additionally provided with fluted disc location hole 302 on cup disk 300, fiber-optic signal, which is worn, to be penetrated in fluted disc
The real-time positioning to fluted disc is realized in location hole 302, fluted disc is facilitated to correct, and fully ensures that the fine rotational for carrying cup disk 300.
In the present embodiment, upper shell 100 is made of the sub- shell less than 8 arcs.Upper shell 100 and lower housing 200 are equal
To be discoid, and it is ferrous metal material.Metal material heat-transfer effect is good so that and incubation reaction quick heating, thermal stability is good,
Reaction efficiency is improved, and is entirely incubated disk and uses surface black, the close light effect of complete machine instrument is ensure that, reduces and secretly make an uproar
Sound background, improves detection sensitivity.It is additionally provided on lower housing 200 for temperature sensor mounted temperature sensor fixing hole
240 (referring to Fig. 5).
In addition, the realization for carrying 300 rotation of cup disk in the present embodiment uses ordinary skill in the art means, such as can be used
Fluted disc motor is installed on by fluted disc motor mount 242 on lower housing 200, will be carried by the mode of shaft and fluted disc motor
Cup disk 300 is set in the shaft of fluted disc motor, to realize the rotation for carrying cup disk 300 under the rotation of shaft.
In conclusion the incubation disk device of the present embodiment is equipped with track switching mechanism, realized under the driving of lead screw motor
Switching of the reaction cup between the groove bodies such as preparatory response cup slot, the first incubation slot and the second incubation slot.Accordingly, with respect to existing
Incubation disk device, the incubation disk device of the present embodiment is not necessarily to reaction cup can be realized by the mode of machinery crawl incubates in difference
The switching between slot is educated, the degree of automation higher, working efficiency higher is more time saving and energy saving, and improves structural stability, leads to
Motor-driven switching is crossed, the risk that reaction cup can not accurately in place is reduced.
The incubation disk device of the present embodiment is equipped with wiper mechanism, and wiper mechanism is carried out magnetic using magnetic wash separation principle
Cleaning：In cleaning, cup disk is carried by rotation so that reaction cup to be cleaned is gone to below cleaning pin hole, with reaction cup
The magnet being oppositely arranged passes through magnetic fields so that magnetic particle is moved to magnet direction, by the cup of reaction cup in motion process
Wall is stopped that magnetic particle is eventually adhering to reaction cup on the inside of the wall of cup of near magnet side；At this point, cleaning needle is deep into instead
Bottom of a cup portion is answered, including that all liq including liquid sample and unreacted reagent is taken out in reaction cup；And magnetic particle
Solid phase carrier will not be pulled away due to being adsorbed on wall of cup；Then, wiper mechanism is injected by cleaning needle into reaction cup clearly again
Washing lotion, the compound to magnetic microsphere as solid phase carrier clean；Cleaning solution is extracted out again later, it is complete after multiplicating
At entire cleaning process.
The incubation disk device of the present embodiment, lower housing are offered along the rotation direction for carrying cup disk for placing response cup
Incubation slot, the sample in reaction cup carry out incubation reaction with reagent in incubation slot, and the magnet mounting base of wiper mechanism, which is located at, incubates
The inside of slot is educated, and magnet is oppositely arranged with reaction cup, multiple magnet are arranged along the rotation direction for carrying cup disk successively, are incubated
This organic matching relationship of slot and wiper mechanism so that incubation reaction can be integrated in one with cleaning.Moreover, the present embodiment
It is incubated disk device and is additionally provided with testing agency's mounting base simultaneously, testing agency's mounting base can be used to install optical de-tection means, with right
Optical detection is carried out using magnetic particle as the compound of solid phase carrier.
It can be seen that incubation, cleaning and detection are integrated in one by the incubation disk device of the present embodiment, overall structure is simple
It is compact, it is easy to use, when needing to execute cleaning or when detection function, without reaction cup is transferred or is grabbed be incubated disk device it
In outer cleaning or test position, relative to the existing incubation disk device with cleaning and testing agency's phase separation, the present embodiment
Incubation disk device reduce experimental implementation, save experimental period, improve conventional efficient.
The incubation disk device of the present embodiment, preparatory response cup slot can in reaction cup before use, preheated to reaction cup,
Reaction cup is individually heated therefore without before, to reduce heating and the reaction time of sample and reagent, is added
Speed reaction process, improves the efficiency of incubation reaction.A circle is offered in the outer ring of the first incubation slot and the second incubation slot
The temperature heating tank of annular, temperature heating tank is interior to install heating mechanism, for being heated to entire incubation reaction.So set
It sets, in the mode of heating for both having overcome existing air bath, reaction cup heating rate is lacked by what ambient temperature was influenced slowly, easily
It falls into, and the incubation reaction temperature at different location in reaction cup can be made consistent, to which the temperature for improving incubation reaction is uniform
Property, it ensure that testing result is to detect at a constant temperature, reduce influence of the environment to detection, improve the anti-of detecting instrument
Interference performance, and then reduce experimental error, improve the accuracy of experimental result.
The incubation disk device of the present embodiment is also further provided with mixing mechanism, and the circulator is in rotary drive motor
It is rotated under driving, to drive the reaction cup of top to be shaken or rotated, and then makes the sample in reaction cup and reagent
It is uniformly mixed, it is ensured that sample is fully reacted with reagent, has further speeded up reaction process, reduces the reaction time, is improved
Reaction efficiency；And mixing mechanism is purely mechanic mixing, to reduce labor intensity.
The embodiments of the present invention provide for example and description, and are not exhaustively or by this reality
It is limited to disclosed form with novel.Many modifications and variations are apparent for the ordinary skill in the art
's.Selection and description embodiment are and to make the general of this field to more preferably illustrate the principles of the present invention and practical application
Logical technical staff is it will be appreciated that various embodiments with various modifications of the utility model to design suitable for special-purpose.
Claims (10)
1. a kind of incubation disk device of chemical illumination immunity analysis instrument, which is characterized in that including upper shell, with the upper shell phase
The lower housing of fastening, and the track switching mechanism on the upper shell, the lower housing is interior to be equipped with rotatable load cup disk,
The load cup disk offers multiple reaction cup loading hole successively along its rotation direction, and the load cup disk is located in the lower housing
The part of lower section is equipped with incubation slot corresponding with the reaction cup loading hole, and reaction cup is through described in reaction cup loading hole entrance
In incubation slot, the incubation slot includes multiple groove bodies, and the track switching mechanism is used for the reaction cup in multiple slots
It is switched between body.
2. the incubation disk device of chemical illumination immunity analysis instrument according to claim 1, which is characterized in that further include being used for
The wiper mechanism of magnetic wash is carried out to the reaction cup, the wiper mechanism includes the cleaning pin hole for wearing cleaning needle,
And the magnet mounting base of multiple magnet is installed, the cleaning pin hole is opened in the upper shell, and in the reaction cup
Under be oppositely arranged, the magnet mounting base be set to the incubation slot most inner side, the magnet for the magnetic wash separation,
And be oppositely arranged with the reaction cup, multiple magnet are arranged in order along the rotation direction for carrying cup disk.
3. the incubation disk device of chemical illumination immunity analysis instrument according to claim 2, which is characterized in that the cleaning machine
Structure is multiple, and multiple wiper mechanisms are arranged along the rotation direction interval for carrying cup disk.
4. the incubation disk device of chemical illumination immunity analysis instrument according to claim 2, which is characterized in that the cleaning machine
Structure further includes the cleaning needle guide pad set on the upper shell, and the cleaning needle can be oriented to by the cleaning needle guide pad, vertically
It is inserted into the cleaning pin hole.
5. the incubation disk device of chemical illumination immunity analysis instrument according to claim 1, which is characterized in that the upper shell
Offer the observation window for observing response cup mobile status；
And/or the upper shell offers the temperature detection hole that sample incubation temperature is detected convenient for temperature probe；
And/or the upper shell offers loading reaction rim of a cup, the reaction cup enters described anti-through loading reaction rim of a cup
Answer a glass loading hole；
And/or the lower housing is additionally provided with testing agency's mounting base for installing optical de-tection means.
6. the incubation disk device of chemical illumination immunity analysis instrument according to claim 1, which is characterized in that the upper shell
Lower surface offers the reaction cup mobile guide groove for being oriented to the movement of reaction cup.
7. the incubation disk device of chemical illumination immunity analysis instrument according to claim 1, which is characterized in that the incubation slot
Including preparatory response cup slot, the first incubation slot and the second incubation slot, the preparatory response cup slot, the first incubation slot and second are incubated
The vertical view of slot is seen in a ring, and is set gradually from the inner ring of the lower housing to outer ring；The preparatory response cup slot, first incubate
It sees in inverted trapezoidal, in order to quickly conduct heat in reaction cup the section for educating slot and the second incubation slot；
The preparatory response cup slot, the first incubation slot and the second incubation slot partly overlap successively, and offer and incubate in overlapping
Educate slot switching port；
The track switching mechanism includes hood, incubation slot switch head and lead screw motor, and the hood and lead screw motor are equal
Set on the upper shell, the incubation slot switch head is set on the screw rod of the lead screw motor, and in the hood, institute
The bottom end for stating incubation slot switch head is configured with card slot, and the size of the card slot and the top of the reaction cup match, so that institute
The top for stating reaction cup is stuck in the card slot, thus will at the incubation slot switching port under the driving of the lead screw motor
The reaction cup switches between the preparatory response cup slot, the first incubation slot and the second incubation slot.
8. the incubation disk device of chemical illumination immunity analysis instrument according to claim 7, which is characterized in that the reaction cup
The space moved radially for the reaction cup is equipped in loading hole, to ensure reaction cup in preparatory response cup slot, the first incubation slot
And second when switching between incubation slot, the reaction cup has enough mobile spaces.
9. the incubation disk device of chemical illumination immunity analysis instrument according to claim 7, which is characterized in that described first incubates
The outer ring for educating slot and the second incubation slot offers temperature heating tank for installing heating mechanism.
10. the incubation disk device of chemical illumination immunity analysis instrument according to claim 1, which is characterized in that further include mixing
Even mechanism, the mixing mechanism include circulator and the rotary drive motor below the circulator, the circulator
Top and the bottom end of the reaction cup are mutually amplexiformed, and the bottom end of the circulator is connected with the shaft of the rotary drive motor,
The rotary drive motor is set in the lower housing.
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| CN201820245141.3U CN207832811U (en) | 2018-02-11 | 2018-02-11 | A kind of incubation disk device of chemical illumination immunity analysis instrument |
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| CN201820245141.3U CN207832811U (en) | 2018-02-11 | 2018-02-11 | A kind of incubation disk device of chemical illumination immunity analysis instrument |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110980170A (en) * | 2020-03-03 | 2020-04-10 | 潍坊市康华生物技术有限公司 | Incubation disc detection track switching mechanism |
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2018
- 2018-02-11 CN CN201820245141.3U patent/CN207832811U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110980170A (en) * | 2020-03-03 | 2020-04-10 | 潍坊市康华生物技术有限公司 | Incubation disc detection track switching mechanism |
| CN110980170B (en) * | 2020-03-03 | 2020-06-09 | 潍坊市康华生物技术有限公司 | Incubation disc detection track switching mechanism |
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