CN207755811U - A kind of pipette tips formula dispersed solid phase microextraction column - Google Patents
A kind of pipette tips formula dispersed solid phase microextraction column Download PDFInfo
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- CN207755811U CN207755811U CN201721901407.7U CN201721901407U CN207755811U CN 207755811 U CN207755811 U CN 207755811U CN 201721901407 U CN201721901407 U CN 201721901407U CN 207755811 U CN207755811 U CN 207755811U
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- baffles
- microextraction column
- pipette tips
- solid phase
- core
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Abstract
A kind of pipette tips formula dispersed solid phase microextraction column, it is related to a kind of pipette tips formula dispersed solid phase microextraction column, purpose of the utility model is to solve solid-phase extraction columns cannot carry out mass disposal sample, cannot be effectively compatible with liquid-transfering gun or full-automatic liquor-transferring system, the not strong problem of applicability.The tapered structure of the utility model solid-phase extraction column, isolated core, resin core and filler core are set from top to bottom in column, and endless totally enclosed space is formed in resin core baffles setting up and down, the utility model extraction column top can individually connect liquid-transfering gun or be connected to liquid-transfering gun by three-dimensional conduit.The utility model pipette tips formula dispersed solid phase microextraction column is easy to operate, time saving, strong applicability, high-volume can carry out sample treatment and detection simultaneously, be more easy to promote the use of in assay laboratory.
Description
Technical field
The utility model is related to a kind of pipette tips formula dispersed solid phase microextraction columns.
Background technology
Existing solid-phase extraction column shape is close with injection needle tube, is straight barrel type.Another solid-phase extraction column upper end is
Infundibulate, convenient for being disposably loaded into more sample in manual operation.But have certain defect, cannot with liquid-transfering gun or
The full-automatic liquor-transferring system compatibility of person, inconvenient for operation, applicability is not strong, is not easy to the combination of sample and resin, extraction efficiency is not
Height is not suitable for the quick processing of batch samples.
Utility model content
Purpose of the utility model is to solve solid-phase extraction columns cannot carry out mass disposal sample, cannot effectively with
Liquid-transfering gun or full-automatic liquor-transferring system compatibility, the not strong problem of applicability and a kind of pipette tips formula dispersed solid phase micro-extraction is provided
Column.
A kind of pipette tips formula dispersed solid phase microextraction column of the utility model, it include microextraction column ontology, three-dimensional conduit, every
Baffle, isolated core, resin core and filler core；
The microextraction column ontology is the cavity body of pyramidal structure, and microextraction column ontology includes being sequentially connected logical imbibition
End, liquid storage cylinder and microextraction column body tail section；Imbibition end is sharp mouth shape；
The imbibition end ends the Jian Zui maximum gauge is identical as microextraction column body tail section diameter, and less than liquid storage cylinder
Diameter；
The filler core is placed in the cavity of imbibition end；Resin core is placed in liquid storage cylinder cavity；Isolated core is placed in micro-extraction
In column body tail section cavity；
The baffles are arcuate structure, and baffles are four, and one end of each baffles is individually fixed in liquid storage cylinder
On madial wall；Four baffles each twos are one group, and two groups of baffles are symmetrically disposed on resin core upper and lower part；In every group
Two baffles are symmetrical arranged along the central axes of liquid storage cylinder, and there are gaps between two baffles end close to each other；
Three-dimensional conduit wherein one is in waist drum shape to conduit, and is connected in the cavity of microextraction column body tail section.
The utility model includes following advantageous effect：
The utility model is that a kind of pipette tips formula dispersed solid phase micro- extraction is established on the basis of traditional SPE (solid-phase extraction column)
Column (Dispersive pipette extraction, DPX tips) is taken, the utility model will pass through the Solid Phase Extraction of syringe type
Column is changed to liquid-transfering sucker type, and one end is tip, and other end caliber size can directly be connect with liquid-transfering gun, can direct profit when experiment
With liquid-transfering gun pipette samples；If sample is less, tip also can efficiently be drawn；DPX tips can with including Hamilton,
The full-automatic liquor-transferring system of the major brands such as Integra, Tecan, Agilent, Gerstel is compatible with, easy to operate, time saving, is fitted
It is strong with property, high-volume sample treatment and detection can be carried out simultaneously, be more easy to promote the use of in assay laboratory.
The pipette tips formula dispersed solid phase microextraction column middle section of the utility model is the cavity body of bulge shape, is placed in it
Resin core, i.e., loose resin；The loose resin dosed can complete the extraction of sample by simply inhaling the process of beating, with liquid
The flowing of body sample, loose resin and determinand can be acted on by liquid turbulence maximumlly with combination；By in micro-extraction
Isolated core is set in column body tail section cavity, i.e. spacer can prevent liquid from pouring in liquid-transfering gun, prevent cross contamination；And it waits for
It is high to survey the object rate of recovery, sample is pure, detection sensitivity improves a lot.And filler core is set in the cavity of imbibition end, i.e.,
The sulfonic acid group filler of 20mg can have alkali compounds strong adsorption capacity.Since pipette tips formula dispersed solid phase microextraction column is
Pyramidal structure, internal diameter are from top to bottom gradually smaller, and therefore, isolated core, resin core and filler core can smoothly be stuck in pipette tips
In formula dispersed solid phase microextraction column cavity.
The utility model is being tied in order to make sample more fully be combined with loose dispersion type resin, also for the two is prevented
The contact excessive with filler during conjunction, and the baffles of arc are set in resin core top and the bottom, and on each baffles
Through-hole is offered, the arc baffles on top are concave up, and there are enough gaps between two arc baffles, are convenient for sample
Smoothly to flowing down, the arc baffles of lower part exist there are enough gaps between two arc baffles to recessed product in this way
During liquid-transfering gun suction is beaten, sample can be in the endless totally enclosed space that arc baffles are formed, with loose resin
It fully combines, and is less than filler as possible and contacts, cause to combine insufficient problem.Moreover, liquid storage cylinder is bulge shape, can give
The enough spaces of sample and loose resin-bonded.
Dynamics is beaten in order to during liquid-transfering gun suction is beaten, give stronger suction, or in order to fully keep pipette tips formula to disperse
Pressure outside solid phase microextraction column intracavitary is consistent, and the utility model devises dismountable three-dimensional conduit, by having certain bullet
One of property tube body is fixed in the cavity of pipette tips formula dispersed solid phase microextraction column upper end, other two tube body can respectively with shifting
Liquid rifle is connected to, can also independent one be connected to liquid-transfering gun, another and air communication are thus to be moved simultaneously using two
The suction of liquid rifle is beaten, or during using liquid-transfering gun to inhale and beat again, the pressure outside guarantee pipette tips formula dispersed solid phase microextraction column intracavitary
Unanimously.Three-dimensional conduit can not also be used, directly by pipette tips formula dispersed solid phase microextraction column and full-automatic liquor-transferring system or liquid relief
Rifle is connected to, and inhale and is beaten.
Pipette tips formula dispersed solid phase microextraction column described in the utility model exchanges using cation and extracts pipette tips, with biography
The SPE approach principle of system is similar, but what is dosed in the utility model pipette tips is loose dispersion type resin, and by liquid, (sample is molten
Liquid, cleaning solution or eluent) flowing and be sufficiently mixed with sample, you can so that solid phase and liquid phase is reached sufficiently thoroughly
Absorption mixing, and sample size is few, it is easy to operate.
Description of the drawings
FIG. 1 is a schematic structural view of the utility model.
Specific implementation mode
Specific implementation mode one：Embodiment is described with reference to Fig. 1, and a kind of pipette tips formula dispersed solid phase of present embodiment is micro-
Extraction column, it includes microextraction column ontology 1, three-dimensional conduit 2, baffles 3, isolated core 4, resin core 5 and filler core 6；
The microextraction column ontology 1 is the cavity body of pyramidal structure, and microextraction column ontology 1 includes being sequentially connected logical suction
Liquid end 1-1, liquid storage cylinder 1-2 and microextraction column body tail section 1-3；Imbibition end 1-1 is sharp mouth shape；
The imbibition end 1-1 Jian Zui end maximum gauges are identical as microextraction column body tail section 1-3 diameters, and less than storage
The diameter of sap cavity 1-2；
The filler core 6 is placed in the 1-1 cavitys of imbibition end；Resin core 5 is placed in liquid storage cylinder 1-2 cavitys；Isolated core 4 is set
In in microextraction column body tail section 1-3 cavitys；
The baffles 3 are arcuate structure, and baffles 3 are four, and one end of each baffles 3 is individually fixed in liquid storage
On chamber 1-2 madial walls；Four 3 each twos of baffles are one group, and two groups of baffles 3 are symmetrically disposed on 5 upper and lower part of resin core；
Two baffles 3 in every group are symmetrical arranged along the central axes of liquid storage cylinder 1-2, and two baffles 3 end close to each other it
Between there are gaps；
Three-dimensional conduit 2 wherein one is in waist drum shape to conduit, and is connected in the cavity of microextraction column body tail section 1-3
It is interior.
Specific implementation mode two：Embodiment is described with reference to Fig. 1, present embodiment and one difference of specific implementation mode
It is：Upward, two 3 intrados of baffles of lower part are downward for two 3 intrados of baffles on top.Other compositions and company
It is same as the specific embodiment one to connect mode.
Specific implementation mode three：Embodiment is described with reference to Fig. 1, present embodiment and one difference of specific implementation mode
It is：Four baffles 3 are all higher than the thickness of resin core 5 at a distance from resin core 5.Other compositions and connection type and specific reality
It is identical to apply mode one.
Specific implementation mode four：Embodiment is described with reference to Fig. 1, present embodiment and one difference of specific implementation mode
It is：Three-dimensional conduit 2 wherein one is in wavy to conduit, and is connected in the cavity of microextraction column body tail section 1-3, and
It is contacted with 4 upper surface of isolated core.Other compositions and connection type are same as the specific embodiment one.
Specific implementation mode five：Embodiment is described with reference to Fig. 1, present embodiment and one difference of specific implementation mode
It is：Through-hole is offered on four baffles 3.Other compositions and connection type are same as the specific embodiment one.
Claims (5)
1. a kind of pipette tips formula dispersed solid phase microextraction column, it is characterised in that it include microextraction column ontology (1), three-dimensional conduit (2),
Baffles (3), isolated core (4), resin core (5) and filler core (6)；
The microextraction column ontology (1) is the cavity body of pyramidal structure, and microextraction column ontology (1) includes being sequentially connected logical suction
Liquid end (1-1), liquid storage cylinder (1-2) and microextraction column body tail section (1-3)；Imbibition end (1-1) is sharp mouth shape；
Imbibition end (1-1) the Jian Zui end maximum gauges are identical as microextraction column body tail section (1-3) diameter, and less than storage
The diameter of sap cavity (1-2)；
The filler core (6) is placed in imbibition end (1-1) cavity；Resin core (5) is placed in liquid storage cylinder (1-2) cavity；Isolation
Core (4) is placed in microextraction column body tail section (1-3) cavity；
The baffles (3) are arcuate structure, and baffles (3) are four, and one end of each baffles (3) is individually fixed in storage
On sap cavity (1-2) madial wall；Four baffles (3) each twos are one group, and two groups of baffles (3) are symmetrically disposed on resin core (5)
Upper and lower part；Two baffles (3) in every group are symmetrical arranged along the central axes of liquid storage cylinder (1-2), and two baffles (3)
There are gaps between end close to each other；
Three-dimensional conduit (2) wherein one is in waist drum shape to conduit, and is connected in the cavity of microextraction column body tail section (1-3)
It is interior.
2. a kind of pipette tips formula dispersed solid phase microextraction column according to claim 1, it is characterised in that two barriers on top
Upward, two baffles (3) intrados of lower part are downward for plate (3) intrados.
3. a kind of pipette tips formula dispersed solid phase microextraction column according to claim 1, it is characterised in that four baffles (3) with
The distance of resin core (5) is all higher than the thickness of resin core (5).
4. a kind of pipette tips formula dispersed solid phase microextraction column according to claim 1, it is characterised in that three-dimensional conduit (2) is wherein
One to conduit in wavy, and be connected in the cavity of microextraction column body tail section (1-3), and with isolated core (4) upper table
Face contacts.
5. a kind of pipette tips formula dispersed solid phase microextraction column according to claim 1, it is characterised in that on four baffles (3)
Offer through-hole.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721901407.7U CN207755811U (en) | 2017-12-29 | 2017-12-29 | A kind of pipette tips formula dispersed solid phase microextraction column |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721901407.7U CN207755811U (en) | 2017-12-29 | 2017-12-29 | A kind of pipette tips formula dispersed solid phase microextraction column |
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| CN207755811U true CN207755811U (en) | 2018-08-24 |
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| CN201721901407.7U Active CN207755811U (en) | 2017-12-29 | 2017-12-29 | A kind of pipette tips formula dispersed solid phase microextraction column |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109781899A (en) * | 2019-03-08 | 2019-05-21 | 无锡微色谱生物科技有限公司 | A method of using the screening of gas chromatography tandem mass spectrometry method and measurement green onion, ginger, 54 kinds of pesticide multi-residues in garlic |
| CN110272487A (en) * | 2019-07-24 | 2019-09-24 | 无锡微色谱生物科技有限公司 | A kind of pipette tips formula dispersed solid phase microextraction column, the purification process based on the pipette tips formula dispersed solid phase microextraction column and application |
| CN110372772A (en) * | 2019-07-30 | 2019-10-25 | 无锡微色谱生物科技有限公司 | A method of His tag fusion protein is purified using pipette tips formula dispersed solid phase microextraction column |
-
2017
- 2017-12-29 CN CN201721901407.7U patent/CN207755811U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109781899A (en) * | 2019-03-08 | 2019-05-21 | 无锡微色谱生物科技有限公司 | A method of using the screening of gas chromatography tandem mass spectrometry method and measurement green onion, ginger, 54 kinds of pesticide multi-residues in garlic |
| CN110272487A (en) * | 2019-07-24 | 2019-09-24 | 无锡微色谱生物科技有限公司 | A kind of pipette tips formula dispersed solid phase microextraction column, the purification process based on the pipette tips formula dispersed solid phase microextraction column and application |
| CN110372772A (en) * | 2019-07-30 | 2019-10-25 | 无锡微色谱生物科技有限公司 | A method of His tag fusion protein is purified using pipette tips formula dispersed solid phase microextraction column |
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