CN207721924U - A kind of accurate drug delivery device of animal nerve Physiological Experiment - Google Patents
A kind of accurate drug delivery device of animal nerve Physiological Experiment Download PDFInfo
- Publication number
- CN207721924U CN207721924U CN201720702678.3U CN201720702678U CN207721924U CN 207721924 U CN207721924 U CN 207721924U CN 201720702678 U CN201720702678 U CN 201720702678U CN 207721924 U CN207721924 U CN 207721924U
- Authority
- CN
- China
- Prior art keywords
- transfusion needle
- clamping part
- drug delivery
- prefabricated pipe
- delivery device
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The utility model discloses a kind of accurate drug delivery devices of animal nerve Physiological Experiment, including infusion device and infusion connector device, the transfusion needle is inserted into prefabricated pipe and enters brain realization administration, the transfusion needle is equipped with the clamp sleeve for improving transfusion needle and prefabricated pipe bonding strength, described sleeve pipe folder includes the fixed part that wrapping is fixed on transfusion needle and the grip shank being located at left and right sides of fixed part, one end of two grip shanks be connected with simultaneously can distending or contraction clamping part, the transfusion needle and prefabricated pipe may pass through clamping part.It is clamping part, prefabricated pipe and transfusion needle successively from outside to inside when use；When clamping part is shunk, clamping part is close to the outer wall of prefabricated pipe, improves transfusion needle and the bonding strength of prefabricated pipe.It can allow animal that stress achieve the effect that pharmaceutical intervention in the case that reducing in this way, it is restless to avoid animal, makes that administration process is stable, ensures that administration is accurate.This utility model is used for zoopery instrument field.
Description
Technical field
The utility model is related to zoopery instrument field, more particularly to a kind of animal nerve Physiological Experiment with accurately giving
Medicine device.
Background technology
It is Neuscience and psychology related discipline scientific research that rat Cerebrum nucleus or ventricles of the brain built-in pipe, which carry out pharmaceutical intervention,
In common method.The positioning of accurate core group is carried out specifically by stereotactic instrument, the preset pipeline of embedment in specified core is rolled into a ball,
After the fixation of denture fixing device cement, pharmaceutical is squeezed into preset pipeline to carry out multichannel electrophysiological recording or observe and record rat
Behavior reaction.Common administering mode is：Micro-pipe tail end of being infused connects gear division needle or scalp acupuncture, and the other end connects micro-injection
Pump.After extracting liquid, gear division needle is injected in prefabricated pipe and is gone and buy Chinese medicine, selection laxative speed is required according to different experiments and stayed
The pipe time.
The prior art has the following disadvantages：
1, laxative syringe needle outer diameter is less than prefabricated bore, after laxative syringe needle enters prefabricated pipe, since animal is in activity
State is easy that laxative syringe needle is made to deviate from, and when carrying out certain experiments, such as Gilles de la Tourette's syndrome, drug effect is fast, the restless row of experimental animal
To be also easy to make laxative pipeline to be detached from or deviateing.It is generally necessary to assistant fixes rat, it is time-consuming and laborious；Especially under artificial limitation
Rat be in stress situation, physical signs does not also meet quiescent condition requirement.
2, due to needing rat being positioned in certain activity space after laxative, liquid-transport pipe-line often stays for a long time
It sets.
3, usually input liquid volume it is few, some reach 1 μ L even it is less, infusion pump pressurization input liquid after, manage
It is possible since there are gas compression, gas leakage leakages etc. in road, so that even if microsyringe, which is shown, has released a certain amount of medicine
Object, but cannot be guaranteed that drug can smoothly enter into specified brain area, therefore, the amount of squeezed into liquid is unable to accurate quantification and guarantor
Card, it is undesirable so as to cause experimental result inaccuracy.
Utility model content
The purpose of this utility model is to provide a kind of animal nerve physiology improving transfusion needle and prefabricated pipe bonding strength
Test accurate drug delivery device.
Technical solution adopted in the utility model is：
A kind of accurate drug delivery device of animal nerve Physiological Experiment, including infusion device and infusion connector device, infusion connect
Mouthful device includes the denture fixing device cement as pedestal and the prefabricated pipe that is located on denture fixing device cement, and infusion device includes woven hose and is located at
The transfusion needle of woven hose head end, transfusion needle be inserted into prefabricated pipe enter brain realize administration, transfusion needle be equipped with improve transfusion needle and
The clamp sleeve of prefabricated pipe bonding strength, clamp sleeve include the fixed part and be located at fixed part or so two that wrapping is fixed on transfusion needle
The grip shank of side, one end of two grip shanks be connected with simultaneously can distending or contraction clamping part, clamping part is being in fixed part just
Front, transfusion needle and prefabricated pipe may pass through clamping part.
As the improvement of said program, the other end of two grip shanks extends to woven hose side.
As the improvement of said program, clamping part is flexible pipe, and pipe is elongated with one on tube wall
The junction of notch, two grip shanks and pipe is located at notch both sides.
As the improvement of said program, clamping part is equipped with anti-skidding layer of silica gel in the side for contacting prefabricated pipe outer wall.
As the improvement of said program, fixed part is equipped with elastic clip, and fixed part is separately connected two by elastic clip
Grip shank.
As the improvement of said program, woven hose is equipped with scale, and the accuracy class of scale is 0.01 μ L-0.1 μ L.
As the improvement of said program, infusion length of tube is 50~100cm.
As the improvement of said program, a diameter of 0.25~0.3mm of transfusion needle.
The beneficial effects of the utility model：This animal nerve Physiological Experiment is defeated with the fixed part connection in accurate drug delivery device
Liquid needle, and clamping part connecting portion, i.e. clamping part and transfusion needle be in stationary state, after distending clamping part, transfusion needle insertion
In prefabricated pipe, it is inserted into clamping part along with prefabricated pipe, is clamping part, prefabricated pipe and transfusion needle successively from outside to inside；Work as clamping part
When contraction, clamping part is close to the outer wall of prefabricated pipe, improves transfusion needle and the bonding strength of prefabricated pipe.Animal can be allowed to exist in this way
Reduce stress in the case of achieve the effect that pharmaceutical intervention, avoid animal it is restless caused by fortuitous event, make administration process it is stable,
Ensure that administration is accurate.
Description of the drawings
The utility model is described in further detail below in conjunction with the accompanying drawings：
Fig. 1 is the front view of drug delivery device；
Fig. 2 is the stereogram of drug delivery device；
Fig. 3 is the sectional view of drug delivery device；
Fig. 4 is the usage state diagram of drug delivery device.
Specific implementation mode
Referring to Fig.1~Fig. 4, the utility model are a kind of accurate drug delivery device of animal nerve Physiological Experiment, including infusion
Device and infusion connector device, infusion connector device include the denture fixing device cement 11 as pedestal and are located at pre- on denture fixing device cement 11
Tubulation 12, present tube are fixed on Rat calvarial push pipe through denture fixing device cement 11, and repeat administration after can retaining, infusion device disappears through alcohol
Sterile isolation is placed after poison.Infusion device includes woven hose 21 and is located at the transfusion needle 22 of 21 head end of woven hose, and transfusion needle 22 is inserted
Enter prefabricated pipe 12 and enter brain realization administration, transfusion needle 22 is equipped with the casing for improving transfusion needle 22 and 12 bonding strength of prefabricated pipe
Folder.
Clamp sleeve includes the fixed part 31 that wrapping is fixed on transfusion needle 22 and the clamping for being located at 31 left and right sides of fixed part
Handle 33, two grip shanks, 33 one end be connected with can distending or contraction clamping part 32, clamping part 32 is in the front of fixed part 31,
Transfusion needle 22 and prefabricated pipe 12 may pass through clamping part 32.
Two grip shanks 33 are fulcrum with fixed part 31 at this time, and grip shank 33 agitates 32 distending of clamping part or receipts similar to lever
Contracting.
Fixed part 31 of this animal nerve Physiological Experiment in accurate drug delivery device connects transfusion needle 22, and clamping part 32 connects
Connecing fixed part 31, i.e. clamping part 32 and transfusion needle 22 be in stationary state, after distending clamping part 32, the insertion prefabricated pipe of transfusion needle 22
In 12, it is inserted into clamping part 32 along with prefabricated pipe 12, is clamping part 32, prefabricated pipe 12 and transfusion needle 22 successively from outside to inside；When
When clamping part 32 is shunk, clamping part 32 is close to the outer wall of prefabricated pipe 12, improves the bonding strength of transfusion needle 22 and prefabricated pipe 12.
It can allow animal that stress achieve the effect that pharmaceutical intervention in reduction in this way, avoid the restless caused unexpected feelings of animal
Condition makes administration process stabilization, ensures that administration is accurate.
As preferred embodiment, the other end of two grip shanks 33 extends to 21 side of woven hose, and fulcrum leans at this time
The intermediate position of nearly grip shank 33, two grip shanks 33 are more prone to torque, more effortless operation.
Further, fixed animal is pacified due to reducing special messenger, greatly reduces working strength, is ensureing experimental precision
It is cost-effective simultaneously.
As preferred embodiment, clamping part 32 is flexible pipe, and clamping part 32 is to shrink under natural conditions
State；Pipe has an elongated notch on tube wall.In the present embodiment, the cross section of clamping part 32 is C-shaped.Two grip shanks
33 are in the both sides of notch with the tie point of clamping part 32, convenient for prying open the notch in the C-shaped section.
As preferred embodiment, clamping part 32 is equipped with anti-skidding layer of silica gel 35 in the side of contact 12 outer wall of prefabricated pipe,
The friction coefficient between contact surface, transfusion needle and prefabricated pipe is improved to be not easy to slip under frictional force and clamp pressure effect.
As preferred embodiment, fixed part 31 is equipped with elastic clip 34, i.e. fixed part 31 passes through elastic clip 34,
Fixed part 31 is separately connected two grip shanks 33 by elastic clip 34.In the present embodiment, elastic clip 34 is the square of intermediate hollow out
Shape sheet body.Elastic clip 34 struts two grip shanks 33, makes two grip shanks 33 shape of falling A similar with elastic clip 34, two grip shanks 33
It is outer to stick up convenient for holding, contributing.
As preferred embodiment, woven hose 21 is equipped with scale 23, and the accuracy class of scale 23 is 0.01 μ L-0.1 μ
L。
Quantitative liquid is sucked by micro drawing liquid pump, can clearly see start index 23 on transparent woven hose 21, when
After selectivity input certain quantity of fluid, can liquid level moving range directly be observed with reference to 21 head end scale 23 of woven hose, with reference to starting
Liquid level scale 23 and termination liquid level scale 23, you can read the amount of squeezed into liquid.Avoid because in woven hose 21 air by
Compression, leakage etc. are interfered and can not judge whether accurate quantitative analysis injects specified brain area to liquid, farthest realize accurate administration.
As preferred embodiment, 21 length of woven hose is 50~100cm.
As preferred embodiment, a diameter of 0.25~0.3mm of transfusion needle 22.
The application method of the drug delivery device is：
Before carrying out micro-administration, first has to carry out alcohol disinfecting processing to transfusion needle 22, use normal saline flushing afterwards, to prevent
Alcohol, which is brought into brain area, to be caused to stimulate and then influences experiment.Then infusion device is connected, 22 interconnecting piece of transfusion needle is connected to defeated
The head end of liquid pipe 21 after coming into full contact with, penetrates into a small amount of 502 glue in the two interface annular, pays attention to that more glue cannot be penetrated into,
Enter pipeline to prevent glue to cause to block；After 22 interconnecting piece of transfusion needle connect sealing with 21 head end of woven hose, clamp sleeve is tested
Whether effectively, light pressing sleeve pipe clamp bilateral grip shank 33, as 32 on off state of clamping part is good and has some tension as effective.
Finally drug delivery device row pre-administration is tested, 21 tail end of woven hose connects 1mL syringe needles exit, sucking life
The full whole woven hose 21 of brine filling is managed, it is microsyringe then to replace syringe；Suck one section of air after, unload it is micro into
Sample device reconnects woven hose 21 after the physiological saline in sucked microsyringe is discharged, sucks a certain amount of drug, until medicine
Liquid liquid level reaches at the scale 23 of woven hose 21.After touch syringe, visible 22 tip of transfusion needle of naked eyes has with infusion action
Liquid bloats and in 23 moving range of scale as the amount of pushed microsyringe, illustrates that infusion function is smooth.It is above-mentioned
In, the effect of sucking one section of physiological saline of filling is to increase the pressure push of infusion, since the medication volume to be inputted is small,
Slight obstruction may form the illusion that drug has squeezed into specified region because of air compression.
It is being ready to after transfusion fluid, hand pinches grip shank 33, and clamping part 32 is made to open, and transfusion needle 22 is inserted into present tube
In, after present tube arrives to 34 waist of elastic clip, grip shank 33 is unclamped, clamping part 32 is made to press on the outside of present tube.It is at this time
Rat can be positioned in a constant volume device, while start timer and being injected, observe the scale 23 on woven hose 21 at this time,
It is moved and is read according to liquid level, the be pumped into amount of control.If be less than pushed away amount, there are resistance greatly caused by air compression or
Person's leakage reaches the requirement of input drug dose accurate quantification if the amount with push-in is consistent.It is required according to different experiments,
It often needs slowly to inject several minutes in experiment, and after let the acupuncture needle remain at a certain point several minutes, flicking grip shank 33, extracts transfusion needle 22, it is young
Whether 22 end of thin observation transfusion needle has liquid residual, if no liquid remains, then illustrates that accurate quantification intervention is administered successfully, after
It can carry out next step behavior observation or electricity physiological signal acquisition.
Certainly, the design creation is not limited to the above embodiment, and the combination of the various embodiments described above different characteristic also may be used
To reach good effect.Those skilled in the art can also make without departing from the spirit of the present invention
It with deformation or replaces, these equivalent modifications or replacement are all contained in the application claim limited range.
Claims (8)
1. a kind of accurate drug delivery device of animal nerve Physiological Experiment, it is characterised in that：It is filled including infusion device and infusion connector
It sets, the infusion connector device includes the denture fixing device cement (11) as pedestal and the prefabricated pipe that is located on denture fixing device cement (11)
(12), the infusion device includes woven hose (21) and the transfusion needle (22) for being located at woven hose (21) head end, the transfusion needle
(22) it is inserted into prefabricated pipe (12) and enters brain realization administration, the transfusion needle (22), which is equipped with, improves transfusion needle (22) and prefabricated pipe
(12) clamp sleeve of bonding strength, described sleeve pipe folder include the fixed part (31) that wrapping is fixed on transfusion needle (22) and are located at solid
Determine the grip shank (33) at left and right sides of portion (31), one end of two grip shanks (33) be connected with simultaneously can distending or contraction folder
Portion (32) is held, the clamping part (32) is in the front of fixed part (31), the transfusion needle (22) and prefabricated pipe (12)
Across clamping part (32).
2. the accurate drug delivery device of animal nerve Physiological Experiment according to claim 1, it is characterised in that：Two grip shanks
(33) the other end extends to woven hose (21) side.
3. the accurate drug delivery device of animal nerve Physiological Experiment according to claim 1, it is characterised in that：The clamping part
(32) it is flexible pipe, the pipe is on tube wall with an elongated notch, two grip shanks (33) and circle
The junction of pipe is located at notch both sides.
4. the accurate drug delivery device of animal nerve Physiological Experiment according to claim 3, it is characterised in that：The clamping part
(32) it is equipped with anti-skidding layer of silica gel (35) in the side of contact prefabricated pipe (12) outer wall.
5. the accurate drug delivery device of animal nerve Physiological Experiment according to claim 3, it is characterised in that：The fixed part
(31) it is equipped with elastic clip (34), the fixed part (31) is separately connected two grip shanks (33) by elastic clip (34).
6. the accurate drug delivery device of animal nerve Physiological Experiment according to any one of claims 1 to 5, feature exist
In：The woven hose (21) is equipped with scale (23), and the accuracy class of the scale (23) is 0.01 μ L-0.1 μ L.
7. the accurate drug delivery device of animal nerve Physiological Experiment according to claim 6, it is characterised in that：The woven hose
(21) length is 50~100cm.
8. the accurate drug delivery device of animal nerve Physiological Experiment according to claim 6, it is characterised in that：The transfusion needle
(22) a diameter of 0.25~0.3mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720702678.3U CN207721924U (en) | 2017-06-15 | 2017-06-15 | A kind of accurate drug delivery device of animal nerve Physiological Experiment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720702678.3U CN207721924U (en) | 2017-06-15 | 2017-06-15 | A kind of accurate drug delivery device of animal nerve Physiological Experiment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207721924U true CN207721924U (en) | 2018-08-14 |
Family
ID=63089887
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720702678.3U Expired - Fee Related CN207721924U (en) | 2017-06-15 | 2017-06-15 | A kind of accurate drug delivery device of animal nerve Physiological Experiment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN207721924U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112263350A (en) * | 2020-11-10 | 2021-01-26 | 南华大学附属南华医院 | Rat craniocerebral three-dimensional positioning puncture device |
| CN113693774A (en) * | 2021-08-05 | 2021-11-26 | 国科赛赋河北医药技术有限公司 | Monkey independently doses protection device of pre-buried pipeline |
-
2017
- 2017-06-15 CN CN201720702678.3U patent/CN207721924U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112263350A (en) * | 2020-11-10 | 2021-01-26 | 南华大学附属南华医院 | Rat craniocerebral three-dimensional positioning puncture device |
| CN113693774A (en) * | 2021-08-05 | 2021-11-26 | 国科赛赋河北医药技术有限公司 | Monkey independently doses protection device of pre-buried pipeline |
| CN113693774B (en) * | 2021-08-05 | 2024-02-27 | 国科赛赋河北医药技术有限公司 | Protection device for monkey autonomous administration embedded pipeline |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN205019519U (en) | A slope inserter for medicine infusion | |
| JP2007513690A (en) | Flash syringe with backflow prevention stopper | |
| KR20230058422A (en) | ASPIRATION SYRINGES AND METHODS THEREOF | |
| RU2019100884A (en) | MEDICAL DEVICE FOR PERCUTANEOUS INJECTION OF AN INJECTED ELEMENT INTO THE TISSUE OF THE ORGANISM | |
| EP2836254B1 (en) | Manual pressure activated application mechanism | |
| CN207721924U (en) | A kind of accurate drug delivery device of animal nerve Physiological Experiment | |
| CN201283143Y (en) | Medicament injection apparatus for chemotherapy | |
| US5518005A (en) | Syringe apparatus for separating blood and method for using same | |
| RU2401669C2 (en) | Syringe, which has elastic unit for facilitating initial aspiration | |
| BRPI0414912A (en) | infuser system and method of administering medication to the patient | |
| CN201353361Y (en) | Disposable multifunctional vein remaining needle | |
| CN110237358A (en) | A kind of high-precision insulin syringe and its application | |
| CN208808738U (en) | A kind of syringe for mouse tail vein | |
| US20220203036A1 (en) | Syringe for detecting pressure change | |
| CN204017111U (en) | Multi-cavity drainage from indwelling irrigating catheter device | |
| CN209574838U (en) | A kind of embryo transplanter | |
| CN204581449U (en) | The diacan of improvement | |
| CN204582153U (en) | A kind of safe type retention needle | |
| CN210158676U (en) | Novel medical needle tube sleeve | |
| CN216148046U (en) | Central venous catheter with closed blood sampling function | |
| CN220142149U (en) | Flushing-free blood storage device | |
| CN203874224U (en) | Connection base structure for injection | |
| CN208974628U (en) | It is a kind of for shifting the syringe of medical fluid | |
| CN105903119A (en) | Paranasal sinus drainage retention device | |
| CN201996923U (en) | Disposable infusion needle head with protective function |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180814 Termination date: 20210615 |