CN207689423U - Chip and mass spectrograph for Mass Spectrometer Method - Google Patents
Chip and mass spectrograph for Mass Spectrometer Method Download PDFInfo
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- CN207689423U CN207689423U CN201721778797.3U CN201721778797U CN207689423U CN 207689423 U CN207689423 U CN 207689423U CN 201721778797 U CN201721778797 U CN 201721778797U CN 207689423 U CN207689423 U CN 207689423U
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Abstract
A kind of chip and mass spectrograph for Mass Spectrometer Method belongs to Mass Spectrometer Method field.Chip has multiple sample target spots, the chip body made of glass slide and Mass Spectrometer Method matrix.Chip has carrier, the chip body for foring sample room.Chip body matches with sample room, and chip body is removably connect with carrier by sample room.Chip body has sample area, and has one-to-one multiple target spots and multiple pits in sample area.Pit extends to the inside of chip body, and metal nanoparticle matrix is combined in pit.The utility model eliminates target plate cleaning and matrix in the detection of MALDI TOF mass spectrographs and two links is added, and reduces the production cost, and improves chip compatibility, is suitable for extensive, large sample size Mass Spectrometer Method.
Description
Technical field
The utility model is related to Mass Spectrometer Method fields, in particular to a kind of chip and mass spectrum for Mass Spectrometer Method
Instrument.
Background technology
Substance assistant laser desorpted ionized flight time (Matrix Assisted Laser Desorption
Ionization Time of Flight, MALDI-TOF) mass spectrograph be grow up the 1980s one kind it is novel soft
Ionize organic mass spectrometry.
MALDI-TOF mass spectrographs have sensitivity and accuracy it is double it is high, detection speeds are fast, sample dosage is few, high resolution,
The features such as high throughput detection.Currently, MALDI-TOF mass spectrographs have been widely used in detecting the biologies such as protein, nucleic acid, polysaccharide
The molecular mass and purity of macromolecular carry out the side such as protein and the molecular vibrational temperature of nucleic acid sequencing and high molecular polymer
Face.
MALDI-TOF mass spectrographs detection basic principle be：
Sample, which is dispersed in matrix, forms cocrystallization.When being formed by the crystal of cocrystallization with laser irradiation, matrix from
Energy is absorbed in laser, sample molecules is allowed to gasify and ionize, and becomes electrically charged ion.Ion is added under forceful electric power field action
Speed, by mass analyzer come separating charged ion, final ion enters detector.It is detected greatly according to the mass-to-charge ratio of ion
Measurer body peak information forms mass spectrogram.
Since the substances such as protein, nucleic acid and polysaccharide and its molecular weight are there is correspondence, mass spectrogram is handled through software
After analysis, the information such as the molecular weight of the substances such as various protein, nucleic acid, polysaccharide and structure in sample can be obtained.
MALDI-TOF mass spectrographs are mainly made of sampling system, ion source, mass analyzer and detector, wherein sample introduction
System is chip or target plate direct injected.Target plate is commonly used in the MALDI-TOF mass spectrographs detection of the current country, can pass through manual cleaning
Realize the reuse of target plate, but there are the following problems：
(1) target plate is cleaned by hand, and time-consuming, tends to have residue；
(2) it is repeatedly used for a long, easily forms deep mixed cut, influence sample and form uniform cocrystallization with matrix；
(3) metallic plates specification is generally 24,48,96 sample target spots, it is difficult to carry out large sample size detection.
Common mass spectrum chip is disposable, about 10,000 yuan or so of higher price, since chip and mass spectrograph are mutual
Matched, so the chip of different mass spectrographs company is incompatible, expensive cost and stringent suitability limits
Its extensive use in scientific research and clinical diagnosis.Currently, being badly in need of a kind of cheap, free of cleaning, good compatibility one
Secondary property chip meets the needs of research work and clinical disease diagnosis can realize the Mass Spectrometer Method of large sample size.
Utility model content
Based on the deficiencies of the prior art, the utility model provides a kind of chip and mass spectrograph for Mass Spectrometer Method, with
Partly or entirely solve the problems, such as one or more in the prior art.The chip for simple detection that is there is provided is inexpensive, exempts from
Cleaning and good compatibility.
The utility model is realized in this way：
In the utility model in a first aspect, providing a kind of chip for simple detection.
Chip for Mass Spectrometer Method includes：
It is formed with the carrier of sample room, there is carrier subsidence part and grand ascending part, grand ascending part to enclose set on the periphery of subsidence part
Edge, sample room are limited jointly by subsidence part and grand ascending part；
The chip body of glass material made of being extended by first surface to second surface, chip body has and sample room
The shape to match, and chip body is removably connected in carrier by sample room, first surface is configured to and subsidence part
In conjunction with first surface, second surface is opposite with first surface and is configured to be exposed to except subsidence part；
Second surface is provided with the first flag sequence and the second flag sequence and is marked by the first flag sequence and second
The sample area that sequence limits, the first flag sequence have multiple first marks being spaced apart positioned at first straight line, the second mark
Note sequence has multiple second marks being spaced apart positioned at second straight line, and first straight line is orthogonal with second straight line, sample area
Crisscross multiple target spots are formed with being indicated with multiple second by multiple first labels；
Sample area is provided with multiple pits of array arrangement, and multiple pits are corresponded with multiple target spots.Pit is from first
Surface is extended to second surface positioned at the inside of chip body.Matrix is combined in pit.Matrix is metal nanoparticle.
In other one or more examples, pit is hemispherical dome structure, and a diameter of 50~1000 μm.
In other one or more examples, a diameter of 200~600 μm of pit.
In other one or more examples, in the first flag sequence, first between two neighboring first mark
Default constant gap.
In other one or more examples, the first default spacing is 1~5mm.
In other one or more examples, in the second flag sequence, second between two neighboring second mark
Default constant gap.
In other one or more examples, the second spacing is equal with the first spacing.
In other one or more examples, chip body is made by glass slide, and glass slide, which has, passes through surface
Metal processing obtains conductive surface layer.
In other one or more examples, the first mark, the second mark are protrusion, and protrusion, which is provided with, to be configured to
The identifier of positioning.
In the second aspect of the utility model, a kind of mass spectrograph is provided.
Mass spectrograph includes laser, is as previously described for the chip of Mass Spectrometer Method.Laser is configured to the chip
The sample area of main body generates laser.
Advantageous effect：
The chip for Mass Spectrometer Method that the utility model embodiment provides has at least the following advantages：
(1) the utility model eliminates target plate cleaning and matrix in the detection of MALDI-TOF mass spectrographs and two links is added, and carries
High detection efficiency.
(2) the utility model eliminates MALDI-TOF mass spectrograph target plates cleaning link, avoids metallic plates from repeating cleaning and draws
Rise the problems such as tending to have residue, easy damaged.
(3) the utility model, which has, to be suitable for large sample size Mass Spectrometer Method with up to 384 sample target spots.
(4) matrix of the utility model, sample target spot, the long width of chip can be according to different samples, difference MALDI-TOF
Mass spectrograph is modified, and improves compatibility, expands application range.
(5) it reduces the production cost, suitable for large-scale use.
Description of the drawings
It, below will be to required use in embodiment in order to illustrate more clearly of the technical solution of the utility model embodiment
Attached drawing be briefly described, it should be understood that the following drawings illustrates only some embodiments of the utility model, therefore should not be by
Regard the restriction to range as, for those of ordinary skill in the art, without creative efforts, may be used also
To obtain other relevant attached drawings according to these attached drawings.
Fig. 1 is the structural schematic diagram at the first visual angle of the chip body that the utility model embodiment provides；
The chip body and the mutually matched structural schematic diagram of carrier provided Fig. 2 shows the utility model embodiment；
Fig. 3 is the mass spectrum design sketch detected after point sample using the chip that the utility model embodiment provides；
Fig. 4 is the mass spectrum design sketch detected after point sample using common mass spectrum chip；
Fig. 5 is the mass spectrum design sketch using metallic plates after point sample.
Icon：101- chip bodies；102- carriers；The sample rooms 201-；202- subsidence parts；The grand ascending parts of 203-.
Specific implementation mode
It is new below in conjunction with this practicality to keep the purpose, technical scheme and advantage of the utility model embodiment clearer
Attached drawing in type embodiment, the technical scheme in the utility model embodiment is clearly and completely described, it is clear that is retouched
The embodiment stated is the utility model a part of the embodiment, instead of all the embodiments.Usually here described in attached drawing and
The component of the utility model embodiment shown can be arranged and be designed with a variety of different configurations.Therefore, below to attached
The detailed description of the embodiments of the present invention provided in figure is not intended to limit claimed the scope of the utility model,
But it is merely representative of the selected embodiment of the utility model.Based on the embodiments of the present invention, ordinary skill people
The every other embodiment that member is obtained without creative efforts belongs to the model of the utility model protection
It encloses.
It should be noted that：Similar label and letter indicate similar terms in following attached drawing, therefore, once a certain Xiang Yi
It is defined, then it further need not be defined and explained in subsequent attached drawing in a attached drawing.
It is in the description of the present invention, it should be noted that term "center", "upper", "lower", "left", "right", " perpendicular
Directly ", the orientation or positional relationship of the instructions such as "horizontal", "inner", "outside" be based on the orientation or positional relationship shown in the drawings, or
The utility model product using when the orientation or positional relationship usually put, be merely for convenience of description the utility model and letter
Change description, do not indicate or imply the indicated device or element must have a particular orientation, with specific azimuth configuration and
Operation, therefore should not be understood as limiting the present invention.In addition, term " first ", " second ", " third " etc. are only used for area
Divide description, is not understood to indicate or imply relative importance.
In the description of the present invention, it should also be noted that, unless otherwise clearly defined and limited, term " is set
Set ", " installation ", " connected ", " connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection,
Or it is integrally connected；It can be mechanical connection, can also be electrical connection；It can be directly connected, intermediary can also be passed through
It is indirectly connected, can be the connection inside two elements.For the ordinary skill in the art, it can be managed with concrete condition
Solve the concrete meaning of above-mentioned term in the present invention.
In the present invention unless specifically defined or limited otherwise, fisrt feature the "upper" of second feature or it
"lower" may include that the first and second features are in direct contact, and can also not be to be in direct contact but lead to including the first and second features
Cross the other characterisation contact between them.Moreover, fisrt feature second feature " on ", " top " and " above " include the
One feature is right over second feature and oblique upper, or is merely representative of fisrt feature level height and is higher than second feature.First is special
Sign second feature " under ", " lower section " and " below " include fisrt feature immediately below second feature and obliquely downward, or only
Indicate that fisrt feature level height is less than second feature.
In the present invention, in the case of not contradiction or conflict, all embodiments, embodiment of the utility model
And feature can be combined with each other.In the present invention, conventional unit, component etc., both can be commercially available, can also
It is made by oneself according to content disclosed by the utility model.In the present invention, normal to some in order to protrude the emphasis of the utility model
The omission that the operation of rule and unit, component carry out, or be only briefly described.
Matrix-assisted laser desorption ionization instrument is widely used in the prior art.Carrying out mass spectrum inspection
When survey, sampling system is generally selected to chip or target plate.But in use, inventor recognizes currently used technology
The shortcomings that target plate easy tos produce residue, has damaged.
Based on this, the utility model proposes a kind of new chips for Mass Spectrometer Method.
Refering to fig. 1 to Fig. 5.
Present embodiments provide a kind of chip for Mass Spectrometer Method.As shown in Fig. 2, chip includes carrier 102, chip master
Body 101 and the matrix (matrix) for being incorporated into chip body 101.Wherein, the chip body 101 for being combined with matrix is arranged at
Carrier 102, and being fixed by fixation by carrier 102, in order to the use in Mass Spectrometer Method.
Carrier 102 is as the component for being used to receiving chip body 101.In addition, carrier 102 and chip body 101 it
Between can connect in a fixed form, or can also be to be connected by dismountable form.In some use-cases, carrier
102 are detachably connected with chip body 101 and will likely bring using upper facility and advantage.Carrier 102 can have it is a variety of can
The structure and shape of choosing.
In the utility model embodiment, carrier 102 is formed with sample room 201.The sample room 201 can accommodate chip master
Body 101.Chip body 101 can be permanently fixed in sample room 201 or temporarily fix.It is " permanently solid
Both it is fixed " instigate carrier 102 and chip body 101 to be made offer as integral structure, both separation will destroy
Between connect so that chip is damaged to a certain extent." temporarily fixing " refers to carrier 102 and chip body
101 are provided to connect or separate as needed, so as to meet some special demands, such as replace chip body 101
And it is multiplexed carrier 102.
But preferably, in the utility model, chip is designed for as disposable product.In the present embodiment
The chip manufacturing for simple detection provided is at low cost and easily fabricated, can be designed according to the actual needs.
There is carrier 102 subsidence part 202 and grand ascending part 203, grand ascending part 203 to enclose the edge set on the periphery of subsidence part 202.
Sample room 201 is limited jointly by subsidence part 202 and grand ascending part 203.The composition of carrier 102 is recessed from grand ascending part 203 to subsidence part 202
And the sample room 201 generated.
Sample room 201 for example can be the cuboid to match with chip body 101.Further, in sample room 201 also
With slot.Sample room 201, which is coordinated by slot with the arms for being formed in chip body 101, to be combined.Slot and arms grafting knot
It closes.In some designs, slot has the gap more than arms, is realized between the two by the way that deformable body is arranged in slot or arms
Grafting stability.The deformable body can issue raw deformation (such as thinning) in certain outer force effect, and work as external force
Partly or entirely disappear, deformable body can partly or entirely restore to original thickness, shape etc..
In other examples, the adjustment mechanism that setting can be conditioned in the sample room 201 of carrier 102, so as to
Receive or accommodate various sizes of chip body 101.Adjustment mechanism for example can be the combination of abutting portion and elastic component.Elastic component
Spring, elastic etc. can be used as.One end of elastic component is incorporated in sample room 201, and the other end of elastic component is connected to conflict
Portion.Abutting portion can extend, shorten under the action of the elastic member.The multiple abutting portions of setting in sample room 201, then by described
Multiple abutting portions contradict with chip body 101 and chip body 101 are made to be limited.After the size of chip body 101 changes, lead to
Adjustment of the adjustment realization of elastic component to abutting portion is crossed, to the space change between abutting portion, and then to being changed size
Chip body 101 limited.
Refering to fig. 1 and Fig. 2, chip body 101 is generally in slice structure, extended by first surface to second surface and
At.First surface and second surface are roughly the same, and the surface area of first surface is even larger than between first surface and second surface
Distance.Chip body 101 has the shape to match with sample room 201.Chip body 101 is detachable by sample room 201
Ground is connected in carrier 102.Chip body 101 is arranged and is defined in the following manner：First surface is configured to and settles
The first surface that portion 202 combines, second surface is opposite with first surface and is configured to be exposed to except subsidence part 202.
The material of chip body 101 can be selected freely.But existing metallic plates are different from, this practicality is new
Type chips main body 101 can be selected as glass, resin, plastics etc..Preferably, chip body 101 is made of glass slide
It forms.Preferably, glass slide, which has to handle by surface metal, obtains conductive surface layer.For example, chip body 101 can be adopted
With for electro-conductive glass ITO (indium tin oxide semiconductor).
As label and positioning, the second surface of chip body 101 is provided with the first flag sequence and the second label sequence
Row and the sample area limited by the first flag sequence and the second flag sequence.First flag sequence has positioned at first straight line
Multiple first marks being spaced apart, the second flag sequence have multiple second marks being spaced apart positioned at second straight line.
First straight line is orthogonal with second straight line.First flag sequence and the second flag sequence can form one and be located at the two of second surface
Dimension coordinate system.Sample area, which has, to be indicated with multiple second by multiple first labels and crisscross forms multiple target spots.
Specifically, relative to first straight line, by the work and second indicated by each first in the first flag sequence
Multiple longitudinal straight lines of straight line parallel.Correspondingly, by the work and first indicated by each second in the second flag sequence
Multiple lateral straight lines of straight line parallel.Multiple longitudinal straight lines above-mentioned and multiple lateral straight lines intersect to form an intersection point.It hands over
It is target spot above-mentioned at point.
In the first flag sequence, the first mark can be arranged with various spacing appropriate.For example, in some examples
In, it is two neighboring first mark the distance between when gradual change.Alternatively, in other examples, between two neighboring first mark
Distance be constant.Alternatively, there is the first constant default spacing between two neighboring first mark, and first is pre-
If spacing is 1~5mm, such as 2mm, 3mm, 4mm, 5mm.As shown in Figure 1, the first mark is presented in digital form.This
In embodiment, the first mark is 1~24 natural number.
Similarly, in the second flag sequence, it can also be used between the second mark and come with the similar mode of the first mark
Arrangement.In a kind of alternative example, the second default constant gap between two neighboring second mark.Further, second
Spacing is equal with the first spacing.As shown in Figure 1, the second mark is presented in the form of letter.In the present embodiment, the second mark is
The English alphabet of A~P.
First mark, the second mark can by by it is various it is appropriate in a manner of be arranged.For example, the first mark, the second mark are
Bulge-structure (such as burr) or dimpled grain.Burr can be hemispherical, pillar, convex block etc..Dimpled grain can be blind cylindrical hole, prism
Shape blind hole.In some instances, protrusion is provided with the identifier for being configured to positioning.Identifier can have appropriate be easy to
Identified shape micro parts.
As the bearing part of detection substance, sample area is provided with multiple pits of array arrangement, multiple pits with it is more
A target spot corresponds.It refers to range that target spot is located at pit restriction that pit is corresponding with target spot.Pit is provided to accommodate matrix
And carrying out Mass Spectrometer Method it is substance to be detected with matrix cocrystallization.
Various proper shapes, such as cylindrical, prismatic, hemispherical, spheroid shape can be set in pit.In this reality
It applies in example, pit is hemispherical dome structure, and a diameter of 50~1000 μm.Alternatively, a diameter of 200~600 microns of pit.One
In some specific alternative examples, the diameter of pit can be 100 microns, 200 microns, 300 microns, 430 microns, 520 microns,
670 microns, 935 microns etc..
Matrix in pit is metal nanoparticle." matrix " is to refer to dispersion sample and form total knot with sample
Crystalline substance, when laser irradiation, matrix absorbs energy from laser, and sample molecules is allowed to gasify and ionize, and becomes electrically charged ion.
Pit is extended to from first surface to second surface positioned at the inside of chip body 101.The development length energy of pit
It is set as desired, such as 0.01~0.05mm.Further, it includes neighbouring first that pit, which is specifically set to two parts,
The second part of the first part on surface and neighbouring second surface.Load gold nano particle in first part, second part load
Nano silver grain.Wherein, the diameter of gold nanoparticle substantially 40~60nm, the diameter substantially 95 of Nano silver grain~
110nm。
In some instances, hydrophilic film can be arranged in pit bottom, and thickness can be 100~200nm.Hydrophily
Film can be flooded profit.Part of the first surface of chip body 101 outside pit is hydrophobicity, the contact angle with water
It is greater than 100 ° or 110 ° or 130 °.
The quantity of pit (or target spot) can be 24,40,90,384.
Based on the above-mentioned chip for Mass Spectrometer Method, a kind of mass spectrograph is provided in the utility model.Mass spectrograph includes
Laser, the chip for Mass Spectrometer Method.Laser is configured to generate laser to the sample area of chip body 101.
Chip provided by the utility model can be used in Mass Spectrometer Method, to various body fluid, as blood, sweat,
Urine etc. is detected.
Experiment is proved as follows for the use of chip and effect.
(1) point sample of the chip provided in the present embodiment and Mass Spectrometer Method effect test
It is drawn on a certain amount of sample directly point to disposable chip using micropipettor, it, will be disposable after natural drying
Chip is placed in MALDI-TOF mass spectrographs and is detected, and can abandon disposable chip after detection, next group sample makes
With new disposable chip.Mass Spectrometer Method effect is as shown in Figure 3.
(2) point sample and Mass Spectrometer Method effect of the mass spectrum chip in existing product
It is drawn on a certain amount of sample directly point to common mass spectrum chip using micropipettor, it, will be primary after natural drying
Property chip, which is placed in MALDI-TOF mass spectrographs, to be detected, and can be abandoned common mass spectrum chip after detection, next lot sample
This uses new mass spectrum chip.Mass Spectrometer Method effect is as shown in Figure 4.
As can be seen from figs. 3 and 4 identical mass spectra peak is obtained after the utility model and the detection of common mass spectrum chip point sample, two
Notable difference is not present in person, meets the mass spectrometric testing requirements of MALDI-TOF.
(3) point sample of metallic plates and Mass Spectrometer Method effect
It is drawn on a certain amount of sample directly point to metallic plates using micropipettor, after natural drying, uses micro shifting
Liquid device is drawn again on a certain amount of matrix point to metallic plates, and natural drying forms cocrystallization, and metallic plates are placed in MALDI-TOF
It is detected in mass spectrograph.After detection, ethanol in proper amount is dipped with dust-free paper, the sample on target plate surface/matrix is wiped, so
Target plate is placed in ethyl alcohol afterwards and is cleaned by ultrasonic 15min, then is cleaned by ultrasonic 10min with deionized water, is finally wiped with dust-free paper
Only, next group pattern detection is carried out after being completely dried.Mass Spectrometer Method effect is as shown in Figure 5.
By Fig. 3 and Fig. 5 it is found that obtaining identical mass spectra peak after the utility model and the detection of metallic plates point sample, the two is not
There are notable differences, meet the mass spectrometric testing requirements of MALDI-TOF.
The above descriptions are merely preferred embodiments of the present invention, is not intended to limit the utility model, for this
For the technical staff in field, various modifications and changes may be made to the present invention.It is all in the spirit and principles of the utility model
Within, any modification, equivalent replacement, improvement and so on should be included within the scope of protection of this utility model.
Claims (10)
1. a kind of chip for Mass Spectrometer Method, which is characterized in that including：
It is formed with the carrier of sample room, there is the carrier subsidence part and grand ascending part, the grand ascending part to enclose set on the subsidence part
Periphery edge, the sample room is limited jointly by the subsidence part and the grand ascending part；
The chip body of glass material made of being extended by first surface to second surface, the chip body have and the sample
The shape that product room matches, and the chip body is removably connected in the carrier by the sample room, described first
Surface is configured to the first surface combined with the subsidence part, and the second surface is opposite with the first surface and is constructed
To be exposed to except the subsidence part；
The second surface is provided with the first flag sequence and the second flag sequence and by first flag sequence and described
The sample area that second flag sequence limits, first flag sequence have multiple first be spaced apart positioned at first straight line
Mark, second flag sequence have positioned at second straight line be spaced apart it is multiple second mark, the first straight line with
The second straight line is orthogonal, and the sample area has indicates that crisscross formation is more by the multiple first label with multiple second
A target spot；
The sample area is provided with multiple pits of array arrangement, and the multiple pit is corresponded with the multiple target spot, institute
It states pit and extends to the combination in the inside of the chip body, the pit from the first surface to the second surface
It is metal nanoparticle to have matrix, the matrix.
2. the chip according to claim 1 for Mass Spectrometer Method, which is characterized in that the pit is hemispherical dome structure,
And a diameter of 50~1000 μm.
3. the chip according to claim 2 for Mass Spectrometer Method, which is characterized in that a diameter of the 200 of the pit~
600μm。
4. the chip according to claim 1 for Mass Spectrometer Method, which is characterized in that in first flag sequence,
The first default constant gap between two neighboring first mark.
5. the chip according to claim 4 for Mass Spectrometer Method, which is characterized in that the first default spacing be 1~
5mm。
6. the chip according to claim 4 or 5 for Mass Spectrometer Method, which is characterized in that in second flag sequence
In, the second default constant gap between two neighboring second mark.
7. the chip according to claim 6 for Mass Spectrometer Method, which is characterized in that the second default spacing with it is described
First default spacing is equal.
8. the chip according to claim 1 for Mass Spectrometer Method, which is characterized in that the chip body is by glass slide system
It forms, the glass slide, which has to handle by surface metal, obtains conductive surface layer.
9. the chip according to claim 8 for Mass Spectrometer Method, which is characterized in that first mark, described second
Mark is protrusion, and the protrusion is provided with the identifier for being configured to positioning.
10. a kind of mass spectrograph, which is characterized in that be used for including laser, such as according to according to any one of claims 1 to 9
The chip of Mass Spectrometer Method, the laser are configured to generate laser to the sample area of the chip body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201721778797.3U CN207689423U (en) | 2017-12-19 | 2017-12-19 | Chip and mass spectrograph for Mass Spectrometer Method |
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| CN201721778797.3U CN207689423U (en) | 2017-12-19 | 2017-12-19 | Chip and mass spectrograph for Mass Spectrometer Method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020103497A1 (en) * | 2018-11-23 | 2020-05-28 | 杭州汇健科技有限公司 | General-purpose nanochip for mass spectrum analysis, preparation method therefor, and application thereof |
| CN111386463A (en) * | 2018-08-30 | 2020-07-07 | 株式会社Lg化学 | Method for relative quantitative analysis of polymers using MALDI mass spectrometry |
-
2017
- 2017-12-19 CN CN201721778797.3U patent/CN207689423U/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111386463A (en) * | 2018-08-30 | 2020-07-07 | 株式会社Lg化学 | Method for relative quantitative analysis of polymers using MALDI mass spectrometry |
| WO2020103497A1 (en) * | 2018-11-23 | 2020-05-28 | 杭州汇健科技有限公司 | General-purpose nanochip for mass spectrum analysis, preparation method therefor, and application thereof |
| KR20210088612A (en) * | 2018-11-23 | 2021-07-14 | 항저우 웰-헬쓰케어 테크놀로지스 컴퍼니 리미티드 | General-purpose nanochip for mass spectrometry and manufacturing method and application thereof |
| KR102533281B1 (en) | 2018-11-23 | 2023-05-16 | 항저우 웰-헬쓰케어 테크놀로지스 컴퍼니 리미티드 | General-purpose nanochip for mass spectrometry and method of manufacturing and using the same |
| US11764047B2 (en) | 2018-11-23 | 2023-09-19 | Hangzhou Well-Healthcare Technologies Co., Ltd | General-purpose nanochip for mass spectrum analysis, preparation method therefor, and application thereof |
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