CN207605608U - Emulsifier and emulsifier unit - Google Patents

Emulsifier and emulsifier unit Download PDF

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Publication number
CN207605608U
CN207605608U CN201721557596.0U CN201721557596U CN207605608U CN 207605608 U CN207605608 U CN 207605608U CN 201721557596 U CN201721557596 U CN 201721557596U CN 207605608 U CN207605608 U CN 207605608U
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China
Prior art keywords
stirring
head
emulsifier
motor
electric
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CN201721557596.0U
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Chinese (zh)
Inventor
丁权
杨乃波
黄谧
马莹莹
柳阳
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BGI Shenzhen Co Ltd
Shenzhen BGI Life Science Research Institute
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BGI Shenzhen Co Ltd
Shenzhen BGI Life Science Research Institute
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Abstract

The utility model provides a kind of emulsifier, including electric DC motor and stirring rod, the stirring rod includes first end and second end, the first end is connected to the shaft of the electric DC motor, the second end is provided with a stirring-head, the extending direction of the shaft of the electric DC motor is axial, the stirring rod is upwardly extended in the axis, the stirring-head has frame-type structure, the frame-type structure is relative to the axially symmetric distribution, and the diameter of the framework of the radial diameter of the stirring rod and the stirring-head is between 1.5 millimeters to 2.5 millimeters.Emulsifier cost provided by the utility model is relatively low, is emulsified to the mixed liquor of small volume convenient for user.The utility model also provides a kind of emulsifier unit.

Description

Emulsifier and emulsifier unit
Technical field
The utility model is related to mixing arrangements, and in particular, to be used to prepare the emulsifier and emulsifier unit of emulsion.
Background technology
Emulsion process is widely used in the fields such as food industry, fine chemistry industry, biomedicine.Emulsion process refer to by Two kinds of immiscible liquid are mixed to form emulsion liquid, i.e., one kind in both liquid become molecule be dispersed in it is another In kind.For example, oil phase and the two-phase mixtures of water phase can form emulsion oil-in-water, wherein oil phase is dispersed phase, and water phase is point Dispersion media;Oil phase and the two-phase mixtures of water phase can also form water-in-oil emulsion, and wherein water phase is dispersed phase, and oil phase is dispersion Medium.Furthermore, it is also possible to multiple emulsion is formed, such as " W/O/W " lotion and " Water-In-Oil packet oil " lotion.It was emulsifying Input energy, such as grinding, stirring, ultrasound are needed in journey, promote two-phase mixtures.Concrete mode, temperature used by emulsion process All there is emulsifying effectiveness and influence in degree, time span, the frequency of input energy (such as mixing speed, ultrasonic power), go forward side by side one Step influences the performance for being formed by lotion.
In the prior art, the device and method for being suitable for a small amount of or micro-scale volume liquid emulsion process are relatively limited, main To include glass syringe method and ultrasonic method.Glass syringe method needs experimenter to push and pull syringe suction mixing two-phase liquid repeatedly, this One process is relatively complicated, takes time and effort, and is also easy to cause the waste of liquid sample.Ultrasonic method is more efficient relative to glass syringe method Fast, but ultrasonic instrument cost is higher, and ultrasound may destroy the structure and property of large biological molecule in lotion (such as protein) Matter.
Utility model content
In view of the foregoing, it is necessary to which the emulsifying device that a kind of cost is relatively low, is operated convenient for user is provided.
The utility model provides a kind of emulsifier, including electric DC motor and stirring rod, the stirring rod include first end And second end, the first end are connected to the shaft of the electric DC motor, which is provided with a stirring-head, the direct current drive The extending direction of the shaft of motor is axial, which upwardly extends in the axis, which has frame-type structure, the frame Type structure is relative to the axially symmetric distribution, and the diameter of the framework of the radial diameter of the stirring rod and the stirring-head is in 1.5 millis Rice is between 2.5 millimeters.
Further, the stirring rod and the stirring-head are made of stainless steel.
Further, the axial length of the stirring rod is between 10 millimeters to 30 millimeters.
Further, the radical length and axial length of the frame-type structure of the stirring-head are between 5 millimeters to 12 millimeters.
Further, the frame-type structure of the stirring-head is selected from circular ring shape, oval ring, water-drop-shaped, sector, triangle and side One kind in shape.
Preferably, the frame-type structure of the stirring-head is circular ring shape, and the diameter of the circular ring shape is between 8 millimeters to 10 millimeters.
Further, which is 6V electric DC motors.
Further, the maximum speed of the electric DC motor is 15000 rpms.
Further, the axial length of the electric DC motor is not more than 25 millimeters, and radical length is not more than 21 millimeters.
Further, which further includes power supply and switch, which connect with the switch and the power supply.
The utility model also provides a kind of emulsifier unit, including emulsifier and syringe-type container, the emulsifier include direct current Electro-motor and stirring rod, the syringe-type container include open end and sealing end, and the volume of the syringe-type container is no more than 25 millis It rises, which includes first end and second end, which is connected to the shaft of the electric DC motor, second end setting There is a stirring-head, the extending direction of the shaft of the electric DC motor is axial, which upwardly extends in the axis, this is stirred Mixing head has a frame-type structure, and the radial dimension of the stirring-head is less than the inner section diameter of the syringe-type container, the stirring rod and should Length of the stirring-head in the axial direction not less than the syringe-type container the open end between the sealing end at a distance from, this is stirred The diameter of the radial diameter of bar and the framework of the stirring-head is mixed between 1.5 millimeters to 2.5 millimeters.
Compared with the prior art, emulsifier and emulsifier unit provided by the utility model are simple in structure, cost is relatively low, use The emulsifier can simplify the operation of emulsion process, reduce the labor intensity of experimenter.The emulsifier has relative to axial direction The stirring-head of the symmetrical frame-type structure in direction, increases the shearing force in whipping process, is conducive to accelerate emulsion process, improves breast Change effect.
Description of the drawings
Fig. 1 is the schematic diagram of emulsifier provided by the utility model.
Fig. 2 is the several embodiments schematic diagram of the stirring-head of emulsifier provided by the utility model.
Fig. 3 is the use state diagram of emulsifier provided by the utility model.
Main element symbol description
Emulsifier 1
Electric DC motor 10
Stirring rod 20
Stirring-head 30,30a,30b,30c,30d,30e
Power supply 40
Switch 50
Shell 60
Syringe cylinder 90
Syringe cap 91
Following specific implementation mode will further illustrate the utility model in conjunction with above-mentioned attached drawing.
Specific implementation mode
The technical solution of the utility model is carried out below in conjunction with preferred embodiments of the present invention and embodiment Description.It should be noted that when a unit is described as " connecting " in another unit, it can be directly to another A unit may be simultaneously present unit placed in the middle.Unless otherwise defined, all of technologies and scientific terms used here by the article It has the same meaning as commonly understood by one of ordinary skill in the art to which the utility model belongs.In the specification of the utility model The title of used element or equipment, which is only for the purpose of describing specific embodiments, is not intended to limit this practicality newly Type.
The utility model provides a kind of emulsifier, liquid sample (being less than 5 milliliters) system for high-speed stirred small volume Standby emulsion.Fig. 1 shows a kind of embodiment of emulsifier provided by the utility model.Emulsifier 1 includes direct current drive Motor 10, stirring rod 20, stirring-head 30, power supply 40 and switch 50.The electric DC motor 10 has shaft 110, the stirring rod 20 include first end 210 and second end 230, and first end 210 is connected to the shaft 110 of the electric DC motor, and second end 230 is set It is equipped with stirring-head 30.Using the extending direction of the shaft 110 as axially, which upwardly extends in the axis.The stirring First 30 have frame-type structure, it is preferable that the frame-type structure is relative to the axially symmetric distribution.The power supply 40 and the switch 50 It is connected with the electric DC motor 10, the power supply 40 and the electric DC motor 10 can be connected to by switch 50, keeps this straight Flow 10 start of electro-motor.
In the present embodiment, the maximum speed of the electric DC motor 10 is not less than 15000 rpms, to pass through The electric DC motor 10 drives the stirring rod 20 for being connected to shaft 110 and stirring-head 30 to carry out high-speed stirred to fluid sample, Accelerate emulsion process, improves emulsifying effectiveness.The electric DC motor of 3V, 6V, 9V or 12V, it is preferable that the electric DC motor 10 be 6V electric DC motors.Preferably, the axial length of the electric DC motor 10 is not more than 25 millimeters (mm), radical length No more than 21mm, make the more miniaturization and lightweight of emulsifier 1, is easy to use.In one embodiment, the electric DC motor Shaft 110 diameter D1 be 2mm, axial length 9mm.It is understood that the electric DC motor 10 can also include Control circuit and corresponding control element, the rotating speed for controlling the electric DC motor 10, to adjust stirring for the emulsifier 1 Mix speed.
The first end 210 of the stirring rod 20 is connected to the shaft 110 of the electric DC motor, 20 second end of stirring rod 230 are provided with stirring-head 30, to drive 30 high-speed rotation of stirring-head by the electric DC motor 10.Preferably, it stirs Bar 20 and stirring-head 30 are made of stainless steel wire, to during reducing use fluid sample in 30 table of stirring rod 20 and stirring-head The adhesive attraction in face reduces loss of the fluid sample in emulsion process.The first end 210 of the stirring rod 20 can pass through welding It is fixedly arranged on the shaft 110 of the electric DC motor, the direct current can also be removably attachable to by magnetic or/and buckle structure The shaft 110 of electro-motor.For the radial diameter D2 of the stirring rod 20 in 1.5mm between 2.5mm, the axial direction of the stirring rod 20 is long Degree is stirred in 10mm to stirring-head 30 between 30mm, can be stretched to the liquid level of liquid in containers sample or less.It needs , it is noted that the radial diameter D2 of the stirring rod 20 refers to the length of stirring rod radial direction herein, in some embodiments In, the radial section of the stirring rod 20 can not be circle, and in this case, the radial diameter D2 of the stirring rod 20 is referred to The length of the long axis of the stirring rod radial section.
The stirring-head 30 has frame-type structure, it is preferable that the frame-type structure is relative to axially symmetric.The frame of the stirring-head 30 Type structure can be oval ring, circular ring shape, water-drop-shaped, sector, triangle, rectangular etc..Fig. 2 shows the frame-type of the stirring-head The several embodiments of structure, stirring-head 30a can be circular ring shapes, and stirring-head 30b can be water-drop-shaped, the stirring-head 30c can be triangle, and stirring-head 30d can be arc-shaped, and stirring-head 30e can be rectangular.It is understood that stirring The frame-type structure for mixing first 30 is not limited merely to above-mentioned shape, other closed type frame-type structures with symmetric shape can also Stirring-head as emulsifier 1.The radical length and axial length of the frame-type structure of the stirring-head 30 are excellent between 5mm-12mm Selection of land, between 8mm-10mm.In a preferred embodiment, which is the frame-type structure of circular ring shape, the circular ring shape The diameter of frame-type structure is between 8mm-10mm.When stirring-head it is oversized when, be not easy to stirring small size liquid-like This;When stirring-head it is undersized when, be unfavorable for quick emulsification.
The diameter D3 of the stirring-head 30 is in 1.5mm between 2.5mm.When the diameter D3 of the stirring-head 30 is undersized, stir Mixing head can deform at high speed;When the diameter D3 of the stirring-head 30 is oversized, the shearing force in stirring can be reduced, no Conducive to quick emulsification.It should be pointed out that the diameter D3 of the stirring-head 30 refers to framework in its frame-type structure herein Diameter, as shown in fig. 1, when the stirring-head 30 is the frame-type structure of ellipse, the diameter D3 of the stirring-head 30 refers to making For the diameter of the framework of elliptical side.In one embodiment, the shaft 110 of the electric DC motor and the axial direction of stirring rod 20 are straight Diameter is equal with the diameter of stirring-head 30, it is preferable that the diameter of three is 2mm.In one embodiment, which stirs with this It is integrated to mix first 30.
The emulsifier 1 can also include a shell 60, for accommodating electric DC motor 10 and power supply 40.Switch 50 can be with It is set on the shell 60, is operated convenient for user.
Correspondingly, the utility model also provides a kind of emulsifier unit, including above-mentioned emulsifier and a syringe-type container, the two It can be used cooperatively, convenient for the water-oil phase liquid sample of emulsification small size.The volume of the syringe-type container is no more than 25mL, can To pull out piston by the common syringe between volume 5-25mL and syringe cap is constituted on the top cover for connecting needle. The syringe-type container includes open end and sealing end.The open end can be used for being added fluid sample to be emulsified.The sealing end Can be closed, can also be a closed opening.It, can be before liquid sample be added, by being opened with this for the latter The matched plug of mouth or lid seal up the opening of the sealing end, after process to be emulsified, which are opened, emulsion It can be flowed out from the sealing end.The emulsifier of the emulsifier unit is identical as the above emulsifier 1, no longer superfluous herein to chat. It will be appreciated by persons skilled in the art that the design based on the utility model, the radial dimension of the stirring-head of the emulsifier is small In the inner section diameter of the syringe-type container, the stirring rod and length of the stirring-head in the axial direction are not less than the syringe-type The distance between the open end of container and the sealing end, so as to so that the stirring-head and stirring rod of the emulsifier extend into this In syringe-type container, at least part stirring-head is made to stretch to the liquid level of liquid sample hereinafter, strong to be carried out to liquid sample Power stirs to get emulsion.
Fig. 3 shows to be prepared with Freund's adjuvant with emulsifier stirring antigen in an embodiment of the utility model and emulsify The use state diagram of liquid.In this embodiment, the piston in the 10mL syringes of commercialization is extracted, leaves behind injection Device cylinder 90.The injection head end of syringe cylinder 90 is covered tightly with syringe cap 91 (or plastic plug), forms the container of one end sealing, then Freund's adjuvant and antigenic solution are pressed 1:1 ratio is added from the opening of 90 other end of syringe cylinder into syringe cylinder 90, mixes The total volume for closing liquid is about 2mL.Keep syringe cylinder 90 vertical by hand-held or fixture, then by the stirring-head 30 of emulsifier 1 Stretch into syringe cylinder 90 to mixed liquor liquid level hereinafter, and stirring-head 30 not encounter the bottom of syringe cylinder 90.It is kept stirring Bar is positioned vertically within the center of syringe cylinder 90, then turns on start or stop and moves emulsifier 1, is stirred by the rotation of stirring-head 30 Liquid.User can judge emulsification degree by observing the color (such as milky, translucent or substantially transparent) of mixed liquor, After the completion of person to be used thinks emulsification, switch is disconnected, stirring rod and stirring-head 30 are taken out from syringe cylinder 90.
The antibody of higher potency is obtained in order to enhance immune response, it is often necessary to special using adjuvant in biomedical sector It is not Freund's complete adjuvant and incomplete Freund's adjuvant.Give full play to the effect of adjuvant, the breast of antigenic solution and Freund's adjuvant Changing effect just seems particularly significant.By using emulsifier provided by the utility model, antigen can be completed in a few minutes It is fully emulsified with adjuvant, it is easy to operate, improve emulsifying power.In addition, substantially being kept away in the use of the emulsifier The loss for having exempted from antigen in emulsion process reduces the cost of emulsion process.
Embodiment
Emulsifier includes 6V electric DC motors, and the axial length of the electric DC motor is 25mm, and radical length is The axial length of 21mm, a diameter of 2mm of the shaft of the electric DC motor, shaft are 9mm.Stirring rod and stirring-head are by diameter It is made of the stainless steel wire of 2mm.One end of the stirring rod is the annulus shape formed by stainless steel wire bending and welding point Stirring-head, the other end of the stirring rod is welded in the shaft of electric DC motor.The diameter of the annulus of the stirring-head exists Between 8mm-10mm.The electric DC motor is powered by power supply (6V, 2A), is provided between the electric DC motor and the power supply Mini ship type switch (10mm*15mm) is used to control being electrically connected for the electric DC motor and the power supply.
Above-described embodiment is the preferable embodiment of the utility model, but the embodiment of the utility model is not by above-mentioned The limitation of embodiment, embodiment of above are only for interpreting the claims.Any one skilled in the art In the technical scope that the utility model discloses, the variation or replacement that can be readily occurred in are included in the guarantor of the utility model Within the scope of shield.

Claims (10)

1. a kind of emulsifier, including electric DC motor and stirring rod, which is characterized in that the stirring rod includes first end and Two ends, the first end are connected to the shaft of the electric DC motor, and the second end is provided with a stirring-head, the direct current The extending direction of the shaft of electro-motor is axial, and the stirring rod is upwardly extended in the axis, and the stirring-head has frame-type Structure, the frame-type structure is relative to the axially symmetric distribution, the frame of the radial diameter of the stirring rod and the stirring-head The diameter of body is between 1.5 millimeters to 2.5 millimeters.
2. emulsifier as described in claim 1, which is characterized in that the stirring rod and the stirring-head are made of stainless steel.
3. emulsifier as described in claim 1, which is characterized in that the axial length of the stirring rod is at 10 millimeters to 30 millimeters Between.
4. emulsifier as described in claim 1, which is characterized in that the radical length and axial direction of the frame-type structure of the stirring-head Length is between 5 millimeters to 12 millimeters.
5. the emulsifier as described in any one of claim 1-4, which is characterized in that the frame-type structure of the stirring-head is selected from circle Annular, oval ring, water-drop-shaped, arc-shaped, triangle and it is rectangular in one kind.
6. the emulsifier as described in any one of claim 1-4, which is characterized in that the frame-type structure of the stirring-head is annulus Shape, the diameter of the circular ring shape is between 8 millimeters to 10 millimeters.
7. emulsifier as described in claim 1, which is characterized in that the electric DC motor is 6V electric DC motors.
8. emulsifier as described in claim 1, which is characterized in that the maximum speed of the electric DC motor is 15000 turns It is per minute.
9. emulsifier as described in claim 1, which is characterized in that the axial length of the electric DC motor is no more than 25 millis Rice, radical length are not more than 21 millimeters.
10. a kind of emulsifier unit, including emulsifier and syringe-type container, the emulsifier include electric DC motor and stirring Bar, the syringe-type container includes open end and sealing end, which is characterized in that the volume of the syringe-type container is no more than 25 millis It rising, the stirring rod includes first end and second end, and the first end is connected to the shaft of the electric DC motor, and described the Two ends are provided with a stirring-head, and the extending direction of the shaft of the electric DC motor is axial, and the stirring rod is in the axis It upwardly extends, there is the stirring-head frame-type structure, the radial dimension of the stirring-head to be less than interior section of the syringe-type container Face diameter, the length of the stirring rod and the stirring-head in the axial direction are not less than the opening of the syringe-type container The distance between end and the sealing end, the diameter of the framework of the radial diameter of the stirring rod and the stirring-head is in 1.5 millis Rice is between 2.5 millimeters.
CN201721557596.0U 2017-11-20 2017-11-20 Emulsifier and emulsifier unit Active CN207605608U (en)

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Publications (1)

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CN207605608U true CN207605608U (en) 2018-07-13

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114307788A (en) * 2021-12-31 2022-04-12 南京岚煜生物科技有限公司 Antigen emulsifying device and using method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114307788A (en) * 2021-12-31 2022-04-12 南京岚煜生物科技有限公司 Antigen emulsifying device and using method thereof

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