CN207575540U - Double sacculus medicine-coated balloon dilating catheters - Google Patents
Double sacculus medicine-coated balloon dilating catheters Download PDFInfo
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- CN207575540U CN207575540U CN201720354731.5U CN201720354731U CN207575540U CN 207575540 U CN207575540 U CN 207575540U CN 201720354731 U CN201720354731 U CN 201720354731U CN 207575540 U CN207575540 U CN 207575540U
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Abstract
The utility model discloses a kind of double sacculus medicine-coated balloon dilating catheters, including push rod；The push rod distal end is respectively fixed with the work sacculus for adhering to medication coat and the occlusion balloon for blocking blood flow；It is equipped in the push rod for installing the guidewire lumen of seal wire, for carrying out the full chamber of full first and to work sacculus for carrying out the full chamber of full second to occlusion balloon, first full chamber and work balloon lumen unicom, the second full chamber and occlusion balloon inner cavity unicom.The utility model using double sacculus, on the one hand reduce blood flow to the scouring effect of drug, reduce drug and come off, on the other hand do not increase conduit diameter size, reduce operating difficulty and surgical injury.
Description
Technical field
The utility model belongs to the field of medical instrument technology, is related to a kind of dilating catheter more particularly to a kind of double sacculus medicines
Object coating sacculus dilating catheter.
Background technology
Narrow arteries is a kind of disease for perplexing the mankind all the time, and in order to cure this kind of disease, the mankind successively pass through
The treatment stages such as bare ball capsule, bare bracket, drug stent are gone through, the defects of various therapeutic schemes also exposes in subsequent practice
Come.Then medicine eluting balloon catheter comes into being, it causes the risk of in-stent restenosis after avoiding implantation stent, not only
Channel is established, and the drug that sacculus is loaded with can effectively inhibit the hyperplasia of smooth muscle cell to prevent for blood fortune by balloon expandable
Hemostatic tube restenosis.
Common single saccule conduit outer wall carries medicine in the prior art, as shown in Figure 1, be a kind of single saccule conduit, drug is defeated
It is sent to diseased region to be expanded, but this medicine eluting balloon catheter has about more than 50% in transmission process in the blood vessels
Drug washed away and lost by quick artery blood flow, wherein the moment that about 30% drug is opened in sacculus, blood vessel diameter
It is not achieved 1 with balloon expandable diameter:When 1, the blood flow quickly flowed washes away.There is only blockings for these drugs lost
The risk of distal vessels, and these drugs being washed can increase the metabolism burden of body.
The improvement of the prior art, mainly also on single saccule medicinal balloon catheter, certain effect is played in improvement, but still
There are many problems, for example, by using the inner surface coating in sacculus flap, are passed in the blood vessels to avoid medicinal balloon catheter
Drug loss in journey, such balloon surface is incomplete to carry prescription formula there is only diseased regions that effective treatment cannot be received
The risk of drug, and it is not avoided that sacculus cannot reach 1 in expansion moment and sacculus with vascular wall diameter:Blood is to medicine when 1
Object washes away.
In addition it is using more sacculus to also have a kind of improved procedure, is respectively provided in the work sacculus both sides for carrying medicine two few
Blood vessel is blocked after distal balloon catheter and proximal balloon, distal balloon catheter and proximal balloon bulging, chamber is formed between two sacculus, adopts
It is had the following disadvantages with the foley's tube of more sacculus：Blood vessel is blocked after distal balloon catheter and proximal balloon bulging, in two sacculus
Between form chamber, and there is the blood of closing in chamber, then the blood closed during full work sacculus nowhere flows, and influences to expand
It fills effect or causes balloon dilatation difficult and be likely to cause the damage of blood vessel, while there is also blood coagulations for closed static blood
Risk；It is complex for operation step, it is unobstructed to influence blood flow；Multiple full chambers are needed, increase the diameter of conduit, and then need using big
The guiding catheter of diameter causes doctor inconvenient, while but also at patient's puncture puncturing hole increase, increase patient's
Pain；In addition there is the foley's tube of multiple sacculus, the area of sacculus and contacts blood is big, and sacculus scratches calcification lesion and narrow
The risk increase of lesion.
Utility model content
The technical problem to be solved by the present invention is to for the drawbacks described above of the prior art, provide a kind of one side
Reduce blood flow to the scouring effect of drug, reduce drug and come off, on the other hand do not increase conduit diameter size, reduce operating difficulty
With double sacculus medicinal balloon catheters of surgical injury.Technical solution is used by the utility model solves its technical problem：One
The double sacculus medicine-coated balloon dilating catheters of kind, including push rod；
The push rod distal end is respectively fixed with the work sacculus for adhering to medication coat and the resistance for blocking blood flow
Fill in sacculus；
It is equipped with to install the guidewire lumen of seal wire, fill for carrying out full first to work sacculus in the push rod
Chamber and for carrying out the full chamber of full second to occlusion balloon, the first full chamber and work balloon lumen unicom, second are full
Chamber and occlusion balloon inner cavity unicom.
In double sacculus medicine-coated balloon dilating catheters, preferably described work sacculus is arranged on occlusion balloon proximal end
In the push rod of side or the work sacculus is arranged in the push rod of occlusion balloon distal end side.
In double sacculus medicine-coated balloon dilating catheters, the diameter of preferably described work sacculus slightly smaller than blocks ball
Capsule diameter or the work balloon diameter are identical with occlusion balloon diameter.
In double sacculus medicine-coated balloon dilating catheters, the active section of preferably described work sacculus is cylinder,
A diameter of 2-15mm, the length of active section is 20-300mm.
In double sacculus medicine-coated balloon dilating catheters, preferably described occlusion balloon is spherical or described resistance
The active section for filling in sacculus is cylinder, a diameter of 2-20mm.
In double sacculus medicine-coated balloon dilating catheters, between preferably described work sacculus and occlusion balloon between
Away from for 0-90mm.
In double sacculus medicine-coated balloon dilating catheters, preferably described push rod proximal end is equipped with catheter block, described
Catheter block is equipped with guidewire port, work balloon dilatation port and occlusion balloon expansion port；
Work sacculus is provided in push rod in work sacculus and fills mouth, and resistance is provided in the push rod in the occlusion balloon
Plug sacculus fills mouth；
Guidewire port and guidewire lumen unicom；
Unicom work balloon dilatation port is distinguished at first full chamber both ends and work sacculus fills mouth；
Unicom occlusion balloon expansion port is distinguished at second full chamber both ends and occlusion balloon fills mouth.
In double sacculus medicine-coated balloon dilating catheters, preferably described work sacculus, occlusion balloon effective length
In the range of corresponding push rod be equipped with for sacculus positioning development positioning device.
In double sacculus medicine-coated balloon dilating catheters, multi-lumen tube that preferably described push rod is integrally formed,
Push rod is equipped with guidewire lumen spaced apart from each other, the first full chamber and the second full chamber along longitudinal direction.
In double sacculus medicine-coated balloon dilating catheters, preferably described push rod is separable assembled structure；
The push rod includes two-chamber outer tube and inner tube, and said inner tube is sleeved in a tube chamber of two-chamber outer tube, described
The tube chamber of inner tube is guidewire lumen, and two tube chambers of two-chamber outer tube are respectively the first full chamber and the second full chamber；
Or the push rod includes an outer tube and two inner tubes, two inner tubes are sleeved in outer tube side by side, in two
Guan Zhong, inner tube tube chamber are guidewire lumen, and the cavity between another inner tube tube chamber and outer tube and inner tube is respectively first to fill
It is full of chamber and the second full chamber；
Or the push rod is set with composition successively for three tube bodies, central lumen is guidewire lumen, the cavity between three pipes
Respectively first full chamber and the second full chamber.
It is washed away to solve the drug on medicinal balloon catheter in expansion moment by blood, the utility model uses one
Kind of double sacculus medicinal balloon catheters set two sacculus in push rod, and one is work sacculus for adhering to medication coat, separately
One is occlusion balloon for blocking blood flow, and occlusion balloon first expands in use, further expansion after blocking blood flow
Work sacculus, can reduce blood flow after blocking blood flow during the balloon inflation that works and work balloon surface drug is washed away
Effect reduces drug and comes off, so as to increase reprinting rate, and then can reduce drugloading rate, mitigates poison of the active medicine to normal cell
Side effect and organism metabolism burden；The single blood flow for blocking balloon occlusion flowing will not form closed blood cavity, Bu Huiying
It rings work balloon dilatation effect or causes balloon dilatation difficult, do not increase the risk of injury of blood vessel, do not increase the risk of blood coagulation；It adopts
With three cavities conduit pipe structure, it is ensured that the diameter that the diameter of conduit applies foley's tube with common single saccule medicine is consistent, not because of conduit
The increase of diameter and the use size for increasing sheath in surgical procedure, do not change doctor's operating habit and operation method, do not increase
Patient by wound probability.
Description of the drawings
Below in conjunction with accompanying drawings and embodiments, the utility model is described in further detail, in attached drawing：
Fig. 1 is the operating diagram that the single saccule conduit of the prior art is partly expanded in the blood vessel；
Fig. 2 is the structure diagram of the utility model embodiment；
Fig. 3 is double sacculus medicine-coated balloon dilating catheters half work signal expanded in the blood vessel of the utility model
Figure；
Fig. 4-7 is the structure diagram of 1 integrally formed push rod inner cavity of the utility model embodiment；
Fig. 8-9 is the structure diagram of the push rod inner cavity of 2 separable assembled of the utility model embodiment.
Specific embodiment
For a clearer understanding of the technical features, objectives and effects of the utility model, now control attached drawing is detailed
Illustrate specific embodiment of the present utility model.
Embodiment 1, as illustrated in figs. 2-7, a kind of double sacculus medicine-coated balloon dilating catheters, including push rod 3；It is described to push away
3 distal end of bar is sent to be respectively fixed with for adhering to the work sacculus 1 of medication coat 5 and the occlusion balloon 2 for blocking blood flow；It is described
It is equipped in push rod 3 for installing the guidewire lumen 6 of seal wire, for carrying out the full chamber 7 of full first to work sacculus 1 and be used for
Carry out the full chamber 8 of full second to occlusion balloon 2, the first full chamber 7 and work 1 inner cavity unicom of sacculus, the second full chamber 8 with
2 inner cavity unicom of occlusion balloon.
The effect one of push rod 3 is to push to operating position for the sacculus 1 that will work, another effect is to undertake conveying
The function of pipeline.Work sacculus 1 and occlusion balloon 2 are weldingly fixed in push rod 3, are worked between sacculus 1 and occlusion balloon 2
Mutual alignment is not construed as limiting, and only need to be both located within 3 distal end of push rod, i.e., described work sacculus 1 is arranged on occlusion balloon 2
In the push rod 3 of proximal end side or the work sacculus 1 is arranged in the push rod 3 of 2 distal end side of occlusion balloon.This reality
It applies in example, work sacculus 1 is located in the push rod 3 of 2 distal end side of occlusion balloon.
There are three function cavity, respectively guidewire lumen 6, the first full 7 and second full chamber 8 of chamber, three chambers for the tool of push rod 3
The mutual not unicom of body.There are many 3 structures of push rod for realizing three function cavitys, and one kind is integrally formed multi-lumen tube, another
Three function cavitys are formed for separable assembled.It is using integrally formed multi-lumen tube as shown in figs. 4-7, push rod 3 is set along longitudinal direction
There are guidewire lumen 6 spaced apart from each other, the first full 7 and second full chamber 8 of chamber.The cross-sectional shape of multi-lumen tube is not construed as limiting, and is only needed
Three function cavitys are spaced from each other, and guidewire lumen 6 is for installing seal wire, and therefore, guidewire lumen 6 needs that cavity is smooth and shape is sharp
In the straight line tube chamber of seal wire movement, the shapes such as round or ellipse, the first full 7 He of chamber are selected in the cross section of general guidewire lumen 6
The cross-sectional shape of second full chamber 8 is not construed as limiting, and can be any shape, generally can according to 3 cross-sectional shape of push rod, lead
Silk 6 location and shape of chamber, the first full 7 and second full chamber 8 of chamber of the maximum cross-section area of arranging.And the first full 7 He of chamber
The quantity of second full chamber 8 is not construed as limiting, and setting quantity can be in 1-3, as shown in Figure 4,5, guidewire lumen 6, the first full chamber 7
With the second full chamber 8 respectively setting one, in Fig. 4, guidewire lumen 6, the first full 7 and second full 8 laid out in parallel of chamber of chamber, guidewire lumen
6 and first full chamber 7 cross section for circle, the second full chamber 8 be semilune.Guidewire lumen 6 is located at the second full chamber 8 in Fig. 5
In, 6 cross section of guidewire lumen is circle, and the first full chamber 7 is ellipse, and the second full chamber 8 is arc.In Fig. 6, the first full chamber
7 settings two, the respectively setting one of 6 and second full chamber 8 of guidewire lumen.In Fig. 7, the second full chamber 8 sets two, 6 He of guidewire lumen
First full chamber 7 sets one.In Fig. 6,6 cross section of guidewire lumen is circle, and the first full 7 and second full chamber 8 of chamber is does not advise
Then shape.In Fig. 7,6 cross section of guidewire lumen is circle, and the first full 7 and second full chamber 8 of chamber is arc surfaced.
As shown in Fig. 2, the both ends of the work sacculus 1 are pyramidal structure, intermediate active section is cylinder, it is a diameter of
2-15mm, the length of work sacculus 1 are generally 30-320mm, and the length of effective length, that is, active section is 20-300mm, effectively long
Degree refers to sacculus after filling in cylindrical shape, the length to play a supportive role in surgical procedure to blood vessel.The table of work sacculus 1
Face is coated with one layer of medication coat 5, and medication coat 5 is mainly disposed to active section.Medication coat 5 can have to inhibit smooth muscle
Taxol drug, rapamycin drug of hyperplasia effect etc..1 diameter of sacculus, the effective length of working select straight according to blood vessel
Diameter selects.Medication coat 5 is applied to the prior art, and details are not described herein.The active section selection of work sacculus 1 is cylindrical, makes
Work sacculus 1 after must filling has good adherence quality, and can have certain length to attach blood vessel, can be effectively by drug
It is transferred on blood vessel wall surface.
The occlusion balloon 2 is that the active section of spherical or described occlusion balloon is cylindrical, a diameter of 2-20mm.Resistance
The diameter of plug sacculus 2 is similarly selected according to blood vessel diameter.The diameter of the work sacculus 1 be slightly smaller than 2 diameter of occlusion balloon or
1 diameter of sacculus that works described in person is identical with 2 diameter of occlusion balloon.2 diameter of occlusion balloon is slightly larger than work sacculus 1, can cause
Occlusion balloon 2 can in advance expand after instrument enters diseased region, blocking blood flow.
Spacing between the work sacculus 1 and occlusion balloon 2 is 0-90mm.It works between sacculus 1 and occlusion balloon 2
Can be located next to, not stay gap therebetween, can also stay it is at regular intervals, such as：Spacing is 10,15,20,30,35,40,
90mm etc..
3 proximal end of push rod is equipped with catheter block 4, and the catheter block 4 is equipped with guidewire port 12, work balloon dilatation port
14 and occlusion balloon expansion port 13；Work sacculus, which is provided with, in push rod 3 in work sacculus 1 fills mouth 9, the occlusion balloon
Occlusion balloon, which is provided with, in push rod 3 in 2 fills mouth 10；Guidewire port 12 and 6 unicom of guidewire lumen；First full 7 both ends of chamber point
Other unicom work balloon dilatation port 14 and work sacculus fill mouth 9；Second full 8 both ends of chamber difference unicom occlusion balloon expands
Port 13 and occlusion balloon fill mouth 10.The channel formed by guidewire port 12, guidewire lumen 6 installs seal wire, guidewire port 12
Face guidewire lumen 6 is set.Work balloon dilatation port 14, the first full chamber 7 and work sacculus fill mouth 9 and are formed to the sacculus that works
1 carries out full channel, full for work sacculus 1.Second full chamber 8 and occlusion balloon fill mouth 10 and are formed to occlusion balloon
2 carry out full channel, full for occlusion balloon 2.
Corresponding push rod 3 is equipped in the range of the work sacculus 1,2 effective length of occlusion balloon positions for sacculus
Development positioning device 11.Effective length range refers to work sacculus 1 or occlusion balloon 2 corresponds to the length range of active section.Development
Developing ring may be used in positioning device 11, its position can be shown under instrument detection.Development positioning device 11 is working respectively
Push rod 3 in sacculus 1 sets one or more developing rings, one or two development is set in the push rod 3 in occlusion balloon 2
Ring.
Embodiment 2, for the basic structure of the present embodiment with embodiment 1, different structures is exactly that the push rod 3 is split group
Assembling structure；
As shown in figure 8, the push rod 3 includes two-chamber outer tube and inner tube, said inner tube is sleeved on one of two-chamber outer tube
In tube chamber, the tube chamber of said inner tube is guidewire lumen 6, and two tube chambers of two-chamber outer tube are respectively that the first full chamber 7 and second is full
Chamber 8；
As shown in figure 9, the push rod 3 includes an outer tube and two inner tubes, two inner tubes are sleeved in outer tube side by side,
In two inner tubes, an inner tube tube chamber is guidewire lumen 6, and the cavity between another inner tube tube chamber and outer tube and inner tube is respectively
First full 7 and second full chamber 8 of chamber；
Other than above structure, push rod is set with composition successively for three tube bodies, and central lumen is guidewire lumen, between three pipes
Cavity be respectively the first full chamber and the second full chamber.
Remaining structure is with embodiment 1, and details are not described herein.
Contrast test：The foley's tube of the foley's tube of the prior art and the utility model is subjected to relevant contrast test
It is as follows：
1st, venting duration comparison is rushed
Any sacculus in commercially available 0.035 ＂ sacculus of tradition Bard and embodiment 1 is done to the comparison for filling venting duration, for side
The double sacculus of face reflection fill venting duration and traditional single saccule fill venting duration indifference.Evaluation method：It is noted in full device
Sacculus is filled nominal pressure by water, and record fills and the pressure release used time.
2nd, residue carrying drug ratio after simulation conveying is washed away
By any sacculus in commercially available 0.035 ＂ sacculus of tradition Bard and embodiment 1,2 using same size, same recipe,
Medicinal balloon is made in same process, identical drugloading rate, and sacculus is delivered to target area half by in-vitro simulated use through same time
Full work sacculus, as shown in Figure 1,3, continues to wash away sacculus to the set time with simulation blood, during this period will be in embodiment
The small sacculus of sacculus fill to blocking and simulate blood flow state, reach and work sacculus cut into HPLC tests after fixed flushing time
Remaining drugloading rate calculates remaining carrying drug ratio.
3rd, simulation uses rear drug reprinting rate
Commercially available 0.035 ＂ sacculus of tradition Bard and sacculus any in embodiment are used into same size, same recipe, identical
Medicinal balloon is made in technique, identical drugloading rate, and extracorporeal blood vessel is removed and extracts blood with 50% methanol aqueous solution by in-vitro simulated use
Drug in pipe, room temperature ultrasound 30min simultaneously centrifuge 10min, and HPLC test doses calculate reprinting rate.Correction data such as following table institute
Show：
Remarks：Data in table are means standard deviation
As shown in Table 1：
(1) this double sacculus and 0.035 ＂ conventional balloons of tradition the Bard almost indifference on venting duration is filled, illustrates this reality
It can reach after the design by lumenal cross-section identical with conventional balloon with novel sacculus and rush venting duration so that in instrument
Reach in operation with the traditional instruments same operating time, do not increase the operating time of doctor, reduce instrument in patient
The potential risk that may be brought when in vivo.
(2) this sacculus after equal flushing time drugloading rate be apparently higher than conventional balloon drugloading rate, illustrate that small sacculus exists
There is blocking blood flow in operation overshoot, effectively prevent the drug of work sacculus by the souring of blood flow, increase on work sacculus
The carrying drug ratio of attachment.
(3) the reprinting rate after this sacculus simulation use is apparently higher than the reprinting rate after conventional balloon simulation use, illustrates
Prevented under the effect of small sacculus work sacculus by blood wash away increased attachment dose can with reprinting to diseased region, increase medicine
Effective reprinting rate of object.
Claims (10)
1. a kind of double sacculus medicine-coated balloon dilating catheters, which is characterized in that including push rod；
The push rod distal end is respectively fixed with the work sacculus for adhering to medication coat and the obstruction ball for blocking blood flow
Capsule；
Be equipped in the push rod for install seal wire guidewire lumen, for work sacculus is carried out the full chamber of full first and
For carrying out the full chamber of full second to occlusion balloon, the first full chamber and work balloon lumen unicom, the second full chamber with
Occlusion balloon inner cavity unicom.
2. double sacculus medicine-coated balloon dilating catheters according to claim 1, which is characterized in that the work sacculus is set
It puts in the push rod of occlusion balloon proximal end side or the work sacculus is arranged on the push rod of occlusion balloon distal end side
On.
3. double sacculus medicine-coated balloon dilating catheters according to claim 1, which is characterized in that the work sacculus
Diameter is slightly smaller than occlusion balloon diameter or the work balloon diameter is identical with occlusion balloon diameter.
4. double sacculus medicine-coated balloon dilating catheters according to claim 1, which is characterized in that the work sacculus
Active section is cylinder, and a diameter of 2-15mm, the length of active section is 20-300mm.
5. double sacculus medicine-coated balloon dilating catheters according to claim 1, which is characterized in that the occlusion balloon is
The active section of spherical shape or the occlusion balloon is cylindrical, a diameter of 2-20mm.
6. double sacculus medicine-coated balloon dilating catheters according to claim 1, which is characterized in that the work sacculus with
Spacing between occlusion balloon is 0-90mm.
7. double sacculus medicine-coated balloon dilating catheters according to claim 1, which is characterized in that the push rod proximal end
Equipped with catheter block, the catheter block is equipped with guidewire port, work balloon dilatation port and occlusion balloon expansion port；
Work sacculus is provided in push rod in work sacculus and fills mouth, and obstruction ball is provided in the push rod in the occlusion balloon
Capsule fills mouth；
Guidewire port and guidewire lumen unicom；
Unicom work balloon dilatation port is distinguished at first full chamber both ends and work sacculus fills mouth；
Unicom occlusion balloon expansion port is distinguished at second full chamber both ends and occlusion balloon fills mouth.
8. double sacculus medicine-coated balloon dilating catheters according to claim 1, which is characterized in that the work sacculus,
Corresponding push rod is equipped with the development positioning device for sacculus positioning in the range of occlusion balloon effective length.
9. double sacculus medicine-coated balloon dilating catheters according to any one of claims 1 to 8, which is characterized in that described
The multi-lumen tube that push rod is integrally formed, push rod is equipped with guidewire lumen spaced apart from each other along longitudinal direction, the first full chamber and second fills
It is full of chamber.
10. double sacculus medicine-coated balloon dilating catheters according to any one of claims 1 to 8, which is characterized in that institute
Push rod is stated as separable assembled structure；
The push rod includes two-chamber outer tube and inner tube, and said inner tube is sleeved in a tube chamber of two-chamber outer tube, said inner tube
Tube chamber for guidewire lumen, two tube chambers of two-chamber outer tube are respectively the first full chamber and the second full chamber；
Or the push rod includes an outer tube and two inner tubes, and two inner tubes are sleeved in outer tube side by side, in two inner tubes,
One inner tube tube chamber is guidewire lumen, the cavity between another inner tube tube chamber and outer tube and inner tube be respectively the first full chamber and
Second full chamber；
Or the push rod is set with composition successively for three tube bodies, central lumen is guidewire lumen, and the cavity between three pipes is distinguished
For the first full chamber and the second full chamber.
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| CN201720312261 | 2017-03-28 | ||
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106994204A (en) * | 2017-03-28 | 2017-08-01 | 杭州唯强医疗科技有限公司 | Double sacculus medicine-coated balloon dilating catheters |
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2017
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106994204A (en) * | 2017-03-28 | 2017-08-01 | 杭州唯强医疗科技有限公司 | Double sacculus medicine-coated balloon dilating catheters |
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