CN207516293U - A kind of concretion method measures the measuring device of molecule electric property - Google Patents
A kind of concretion method measures the measuring device of molecule electric property Download PDFInfo
- Publication number
- CN207516293U CN207516293U CN201721264720.4U CN201721264720U CN207516293U CN 207516293 U CN207516293 U CN 207516293U CN 201721264720 U CN201721264720 U CN 201721264720U CN 207516293 U CN207516293 U CN 207516293U
- Authority
- CN
- China
- Prior art keywords
- module
- piezoelectric ceramic
- ceramic tube
- lifting platform
- data
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Investigating Or Analysing Biological Materials (AREA)
Abstract
A kind of concretion method measures the measuring device of molecule electric property, the center of lifting platform is vertically fixed to be embedded with a piezoelectric ceramic tube in vertical cylinder shape, the top and bottom end of piezoelectric ceramic tube respectively pass through the top and bottom of lifting platform, and the bottom face center position of piezoelectric ceramic tube is provided with an Au probe electrode；Supporting rod makes somebody a mere figurehead lifting platform in the surface of sample stage, and Au probe electrode is located at the surface of sample stage, and a rectangular sample cell is provided at the end face center of sample stage, gold plaque is placed in sample cell；The system module of the utility model includes piezoelectric ceramic tube control module, linear position actuator control module, data acquisition module, data processing module, experiment adjustment module and electrochemical workstation in real time.It is the utility model simple structure, of low cost, it is easy to operate, there is direct, accurate, real-time, easy to operate, left-hand seat easy to learn, abundant intramolecule information can be provided by electrical measurement on single molecules level.
Description
Technical field
The utility model is related to measure molecule electric property technical field more particularly to a kind of concretion method to measure molecule electricity
Device for measuring properties.
Background technology
Unimolecule conductance measurement technology is that a kind of important technology of individual molecule electrical properties is measured using electrical method.It is single
Molecular Detection（Single Molecule Detection,SMD）Technology is different from general conventional detection technology, observes
It is the individual behavior of individual molecule, molecule detection is in fields such as Environmental security, biotechnology, sensor, food securities
It is widely used.Single Molecule Detection reaches the limit of molecular detection, is the target that people pursue for a long time.With traditional analysis
Method is compared, and Single Molecule Detection method research system is in the individual behavior under nonequilibrium condition, or the fluctuation under equilibrium state
Behavior, thus be particularly suitable for research chemistry and biochemical reaction kinetics, the interaction of biomolecule, structure and functional information,
Major disease early diagnosis, pathological study and high-flux medicaments sifting etc..Unimolecule conductance measurement technology is gradually applied to
Field other than molectronics is all shown huge in fields such as physical chemistry, analytical chemistry, bio-sensing and gene sequencing
Development potentiality.
In recent years, with the development of molectronics research, unimolecule electric property and its measuring method are by increasingly
More concerns shows emblem technology molecular detection electrical properties, atomic force microscope as utilization scans probe（AFM）And single molecular fluorescence
The existing unimolecule conductance measurement technologies such as analysis, complicated, accuracy is poor.
Invention content
To solve above-mentioned technological deficiency, the utility model provides a kind of concretion method simple in structure and measures molecule electricity
Learn performance measuring device, can directly, accurately, molecule electric property is measured in real time.
Technical solution includes lifting platform, the center of the lifting platform used by the utility model solves its technical problem
The vertical piezoelectric ceramic tube fixed embedded with one in vertical cylinder shape, the top and bottom end of the piezoelectric ceramic tube respectively pass through
The top and bottom of lifting platform, the bottom face center position of the piezoelectric ceramic tube are provided with an Au probe electrode, and gold is visited
The top of pin electrode is connected with the bottom face fixed vertical of piezoelectric ceramic tube；Four edges of the lifting platform are set respectively
There is a supporting rod that four roots and tops penetrate lifting platform, four corners of the supporting rod and sample stage are vertically connected, described
Supporting rod lifting platform is maked somebody a mere figurehead in the surface of sample stage, and the lifting platform is parallel with sample stage is fixed on supporting rod
On, the Au probe electrode is located at the surface of sample stage, and the Au probe electrode is made of Au materials, the sample
A rectangular sample cell is provided at the end face center of platform, gold plaque is placed in the sample cell；
The linear position actuator that a drive lifting platform rises or falls along four supporting rods is provided on the lifting platform,
There are displacement sensor, the linear position actuator and displacement sensor and linear position actuator control module electricity on lifting platform
Property connection；
Further include the speed of service, a range ability that will control linear position actuator, voltage, the piezoelectricity of piezoelectric ceramics
The speed of service parameter setting of ceramics is good, and upon power-up of the system, just directly initializes the initialization module of all parameters；
One is electrically connected with piezoelectric ceramic tube, for piezoelectric ceramic tube to be controlled to rise or fall, the fortune of piezoelectric ceramic tube
The piezoelectric ceramic tube control module of the parameters such as scanning frequency degree, the voltage for adjusting piezoelectric ceramic tube Au probe electrode；
One for acquire Au probe electrode measurement data, the raw data acquisition of measurement and be recorded in computer
Data acquisition module；
One for will the data from data acquisition module, carry out operation, processing, obtain electric conductivity value, molecular length value
The data processing module of parameter；
The information of one reception data acquisition module, instruction electrochemical workstation work, piezoelectric ceramic tube, straight-line displacement are driven
Dynamic device work, and the experiment recorded data in computer adjusts module in real time；
The electrochemical workstation of one progress IV measurement；
One data export module for initial data being exported to external storage equipment or printer.
The utility model further includes a data disaply moudle being electrically connected with the data processing module.
Data acquisition module described in the utility model includes current amplifier, data acquisition module and data display model electricity
Property is connected.
Data processing module described in the utility model is electrically connected with real-time regulation experiment operation module, and described is real-time
Regulation experiment operation module passes through network connection with electrochemical workstation.
Sample stage described in the utility model is lamellar in horizontal rectangular, the corner location of bottom surface four of the sample stage
Place is respectively fixed with a sample stage stabilizer blade.
Lifting platform described in the utility model is lamellar in horizontal rectangular.
It is the utility model simple structure, of low cost, it is easy to operate, it is completely embedded between each composition device, systematicness
By force, there is direct, accurate, real-time, easy to operate, left-hand seat easy to learn, it can be by simple electrical measurement in unimolecule
Abundant intramolecule information is provided in level.It can quickly, efficiently and accurately test out unimolecule electrical information and molecule
Between electrical information.
Description of the drawings
Fig. 1 is the structure diagram of the utility model.
Fig. 2 is the utility model circuit theory schematic diagram.
Fig. 3 is the utility model measurement process unimolecule status diagram.
In figure：1st, lifting platform, 2, sample stage, 21, sample stage stabilizer blade, 22, sample cell, 23, supporting rod, 24, gold plaque, 11,
Piezoelectric ceramic tube, 12, Au probe electrode, 13, piezoelectric ceramic tube control module, 14, linear position actuator, 15, straight-line displacement
Driver control module, 16, displacement sensor, 31, initialization module, 32, data acquisition module, 33, electrochemical workstation,
34th, data disaply moudle, 35, data processing module, 36, experiment adjustment module in real time, 37, data export module.
Specific embodiment
Presently in connection with attached drawing, the technical scheme in the utility model embodiment is clearly and completely described, this figure is
Simplified schematic diagram only illustrates the basic structure of the utility model in a schematic way.
According to Fig. 1, the utility model includes lifting platform 1, sample stage 2 and system module, and the lifting platform 1 is in level
Thin Rectangular plate, the center of the lifting platform 1 is vertically fixed to be embedded with a piezoelectric ceramic tube 11 in vertical cylinder shape, the pressure
The top and bottom end of electroceramics pipe 11 respectively penetrate the top and bottom of lifting platform 1, the bottom end of the piezoelectric ceramic tube 11
Face center position is provided with an Au probe electrode 12, and the top of Au probe electrode 12 and the bottom face of piezoelectric ceramic tube 11 are fixed
It is vertically connected, four edges of the lifting platform 1 are respectively arranged with the supporting rod 23 that four roots and tops penetrate lifting platform 1, institute
Four corners of the supporting rod 23 stated and sample stage 2 are vertically connected, and the supporting rod 23 makes somebody a mere figurehead lifting platform 1 in sample
The surface of platform 2, and the lifting platform 1 is parallel with sample stage 2 is fixed on supporting rod 23,12, the Au probe electrode
In the surface of sample stage 2, the Au probe electrode 12 is made of Au materials, is provided on the top surface of the lifting platform 1
One linear position actuator 14 is provided with a displacement sensor 16 on 1 side of lifting platform.The sample stage 2 is in water
Flat rectangular is lamellar, and a sample stage stabilizer blade 21 is respectively fixed at the corner location of bottom surface four of the sample stage 2, described
Sample stage 2 end face center at be provided with a rectangular sample cell 22, gold plaque 24, sample cell 22 are placed in the sample cell 22
It is electrically connected with gold plaque 24, the linear position actuator 14 and displacement sensor 16 and linear position actuator control module
15 are electrically connected, and the piezoelectric ceramic tube 11 is electrically connected with piezoelectric ceramic tube control module 13.
It is shown according to fig. 2, in the system module of the utility model, the piezoelectric ceramic tube control module 13 and straight-line displacement
Driver control module 15 is electrically connected with initialization module 31；Data acquisition module 32 is electrically connected with Au probe electrode, institute
Stating data acquisition module 32 will acquire including current amplifier, signal feedback system and data acquisition display screen, current amplifier
To electric signal be amplified and amplified electrical signal data acquired into display screen by data and show, signal feedback is
It unites amplified electrical signal data feeding back to the current amplifier.The data acquisition module 32 passes through conducting wire and number
It is electrically connected according to processing module 35, data disaply moudle 34.Adjustment module 36 is electric in real time with experiment for the data processing module 35
Property connection, the experiment adjusts module 36 and electrochemical workstation 33 and passes through network connection in real time.
In Fig. 3, when the distance between Au probe electrode and sample are sufficiently small（Such as less than 1nm）, electric current is with gold spy
The variation of pin electrode and the distance between sample and change, during decline the needle point of Au probe electrode can moment and sample connect
It touches, then, the needle point of Au probe electrode is controlled by piezoelectric ceramics management and control molding block, will not be contacted with gold plaque, can be with gold plaque sample
On molecule contacts.By the distance between the Au probe electrode, gold plaque electrode setting to monomolecular length dimension.With list
The contact and disconnection of molecule between two electrodes（A is the contact condition of unimolecule between two electrodes, and B is unimolecule
Off-state between two electrodes）, to detect the variation of electric signal in real time, so as to obtain monomolecular electrical information.
The content and function that the utility model whole device is included are as follows：Initialization module 31：In the mistake of system operation
Cheng Zhong, needs to control the speed of service of linear position actuator, range ability, the voltage of piezoelectric ceramic tube, piezoelectric ceramic tube
The series of parameters such as the speed of service；During operation, the linear position actuator 14 started to work at first（It needs working
During adjust its parameter）；First by linear position actuator（Model PICOMOTOR 8742-4-KIT）Driving, makes lifting
Platform 1 declines a certain distance；Then made between Au probe electrode 12 and sample by the control of piezoelectric ceramic tube control module 13 again
Distance is kept constant（Such as 1nm）, piezoelectric ceramic tube control module 13 is used for adjusting voltage, the piezoelectric ceramic tube of piezoelectric ceramic tube
The parameters such as the speed of service；Because in Nano grade, whole system is very difficult to stable, it is therefore desirable to multiple continuous tune
Section.By the distance between Au probe electrode 12, gold plaque electrode setting to monomolecular length dimension.As unimolecule is in two electricity
Contact and disconnection between pole, to detect the variation of electric signal in real time, so as to obtain monomolecular electrical information.Au probe
Electrode 12 passes information to data acquisition module 32：Data acquisition module 32 during the experiment, is needed according to different experiments
Relevant parameter is adjusted in real time, including parameters such as bias, displacement, distance, sample rates；Data processing module 35 receives data acquisition
32 information of module carries out operation, processing, obtains the parameters such as electric conductivity value, molecular length value, and it is real-time to return to experiment with reference to data status
Module 36 is adjusted, instruction electrochemical workstation 33 works, carries out IV measurements, draw IV curves and keep records of data, piezoelectricity pottery
Porcelain tube 11, linear position actuator 14 work, and record data in computer；Experiment adjusts operation module 36 in real time：Root
According to different experiments, during the experiment, need to adjust relevant parameter in real time, including ginsengs such as bias, displacement, distance, sample rates
Number；Data export module 37：Initial data can be exported to external storage equipment or printer etc..
Claims (6)
1. a kind of concretion method measures the measuring device of molecule electric property, it is characterised in that：Including lifting platform（1）, the liter
Platform drops（1）Center vertically it is fixed embedded with one be in vertical cylinder shape piezoelectric ceramic tube（11）, the piezoelectric ceramic tube（11）
Top and bottom end respectively pass through lifting platform（1）Top and bottom, the piezoelectric ceramic tube（11）Bottom face center
An Au probe electrode is provided at position（12）, Au probe electrode（12）Top and piezoelectric ceramic tube（11）Bottom face fix
It is vertically connected；The lifting platform（1）Four edges be respectively arranged with four roots and tops and penetrate lifting platform（1）Supporting rod
（23）, the supporting rod（23）With sample stage（2）Four corners be vertically connected, the supporting rod（23）It will lifting
Platform（1）It makes somebody a mere figurehead in sample stage（2）Surface, and the lifting platform（1）With sample stage（2）It is parallel to be fixed on supporting rod（23）
On, the Au probe electrode（12）Positioned at sample stage（2）Surface, the Au probe electrode（12）By Au material systems
Into the sample stage（2）End face center at be provided with a rectangular sample cell（22）, it is upper in the sample cell to place gold
Piece（24）；
The lifting platform（1）On be provided with the linear position actuator that a drive lifting platform rises or falls along four supporting rods
（14）, lifting platform（1）On have displacement sensor（16）, the linear position actuator（14）And displacement sensor（16）With straight line
Displacement driver control module（15）It is electrically connected；
Further include the speed of service, a range ability that will control linear position actuator, voltage, the piezoelectric ceramics of piezoelectric ceramics
Speed of service parameter setting it is good, and upon power-up of the system, just directly initialize the initialization module of all parameters；
One and piezoelectric ceramic tube（11）It is electrically connected, for piezoelectric ceramic tube to be controlled to rise or fall, the fortune of piezoelectric ceramic tube
The piezoelectric ceramic tube control module of the parameters such as scanning frequency degree, the voltage for adjusting piezoelectric ceramic tube Au probe electrode（13）；
One is used to acquire Au probe electrode（12）The data of measurement acquire the raw data acquisition of measurement and the data of record
Module（32）；
One for will the data from data acquisition module, carry out operation, processing, obtain electric conductivity value, molecular length value parameter
Data processing module（35）；
The information of one reception data acquisition module, instruction electrochemical workstation work, piezoelectric ceramic tube, linear position actuator
Work, and the experiment of data record is adjusted into module in real time（36）；
The electrochemical workstation of one progress IV measurement（33）；
One data export module for initial data being exported to external storage equipment or printer（37）.
2. concretion method measures the measuring device of molecule electric property according to claim 1, it is characterised in that：Further include one
With data processing module（35）The data disaply moudle of electric connection（34）.
3. concretion method measures the measuring device of molecule electric property according to claim 1, it is characterised in that：The data are adopted
Collect module and include current amplifier, data acquisition module is electrical connected with data display model.
4. a kind of concretion method according to claim 1 measures the measuring device of molecule electric property, it is characterised in that：It is described
Data processing module and real-time regulation experiment operation module be electrically connected, the real-time regulation experiment operation module and electrification
It learns work station and passes through network connection.
5. a kind of concretion method according to claim 1 measures the measuring device of molecule electric property, it is characterised in that：It is described
Sample stage（2）Sample stage lamellar in horizontal rectangular, described（2）The corner location of bottom surface four at be respectively fixed with one
Sample stage stabilizer blade（21）.
6. a kind of concretion method according to claim 1 measures the measuring device of molecule electric property, it is characterised in that：It is described
Lifting platform（1）It is lamellar in horizontal rectangular.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721264720.4U CN207516293U (en) | 2017-09-29 | 2017-09-29 | A kind of concretion method measures the measuring device of molecule electric property |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721264720.4U CN207516293U (en) | 2017-09-29 | 2017-09-29 | A kind of concretion method measures the measuring device of molecule electric property |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207516293U true CN207516293U (en) | 2018-06-19 |
Family
ID=62533073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721264720.4U Expired - Fee Related CN207516293U (en) | 2017-09-29 | 2017-09-29 | A kind of concretion method measures the measuring device of molecule electric property |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN207516293U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109444487A (en) * | 2018-12-21 | 2019-03-08 | 义乌臻格科技有限公司 | A kind of probe in detecting head and probe detection device that probe spacing is continuously adjustable |
| CN109580714A (en) * | 2017-09-29 | 2019-04-05 | 武汉科技大学 | A kind of measuring system of concretion method measurement molecule electric property |
-
2017
- 2017-09-29 CN CN201721264720.4U patent/CN207516293U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109580714A (en) * | 2017-09-29 | 2019-04-05 | 武汉科技大学 | A kind of measuring system of concretion method measurement molecule electric property |
| CN109444487A (en) * | 2018-12-21 | 2019-03-08 | 义乌臻格科技有限公司 | A kind of probe in detecting head and probe detection device that probe spacing is continuously adjustable |
| CN109444487B (en) * | 2018-12-21 | 2024-03-29 | 义乌臻格科技有限公司 | Probe detection head with continuously adjustable probe spacing |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108485972B (en) | Microfluidic chip for cell tissue culture and real-time monitoring and use method thereof | |
| CN207516293U (en) | A kind of concretion method measures the measuring device of molecule electric property | |
| CN109142797B (en) | Droplet type scanning ion conductance microscope, probe thereof and scanning method | |
| Thatenhorst et al. | Effect of sample slope on image formation in scanning ion conductance microscopy | |
| CN1828308A (en) | On-line testing and analyzing device and method for microelectromechanical system component material parameter | |
| CN103558367B (en) | System and method for measuring electrical characteristics of biological cells through nano-electrode array under physiological conditions | |
| CN110108905B (en) | Method and device for detecting membrane potential and nerve cell membrane repairing behaviors of nerve cells | |
| CN105527462A (en) | Method for measuring single alive myocardial cell action potential and pulsing force by atomic force microscope | |
| CN109580714A (en) | A kind of measuring system of concretion method measurement molecule electric property | |
| CN107064639A (en) | It is a kind of to split system and its application method that connection measures unimolecule electric property | |
| CN102353818A (en) | Device and method for evaluating neuron-like differentiation degree of PC12 cell | |
| CN101089591B (en) | Method for measuring current transformation liquid shear strength | |
| CN104062503A (en) | Data acquisition device for measuring in vitro biological tissue electrical impedance | |
| CN109682745B (en) | Single cell parameter measuring method and device | |
| CN202256386U (en) | Device for evaluating neuron-like differentiation degree of PC12 cells | |
| CN108732387A (en) | A kind of probe sample distance controlling method and system of SICM | |
| CN207832826U (en) | Conducting probe frame for afm scan probe to be clamped | |
| CN103615964B (en) | The thin liquid film thickness self-operated measuring unit that a kind of environment is controlled | |
| CN113639823B (en) | High-precision liquid level detection system and method based on ripple image recognition | |
| CN2733368Y (en) | Precision measurement device for film resistor or chip resistor | |
| CN107290590A (en) | A kind of method that noncontact mode mutation connection measures unimolecule electric property | |
| CN209231099U (en) | A kind of material mesoscopic scale simple tension measuring system | |
| CN221039252U (en) | Piezoelectric signal detection system of thin film piezoelectric material | |
| CN101793663A (en) | Jump multi-resolution scanning probe microscope | |
| CN114965166B (en) | Shear rheometer for measuring trace sample |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180619 Termination date: 20200929 |