CN207502399U - A kind of dumbbell optical fiber detects micro flow chip - Google Patents
A kind of dumbbell optical fiber detects micro flow chip Download PDFInfo
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- CN207502399U CN207502399U CN201721317567.7U CN201721317567U CN207502399U CN 207502399 U CN207502399 U CN 207502399U CN 201721317567 U CN201721317567 U CN 201721317567U CN 207502399 U CN207502399 U CN 207502399U
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Abstract
The utility model discloses a kind of dumbbell optical fibers to detect micro flow chip, including five core fibres 1, dumbbell optical fiber 2, multimode fibre 3, microchannel module 4, wide spectrum light source 5, five core fibre beam splitters 6, spectrometer 7, micro-injection pump 8, the 1st waste liquid pool 9, computer 10；Five core fibre of wielding neck on the left of 2cm long dumbbells optical fiber, right side welding multimode fibre, through burn into 50nm thickness SPR（Surface plasma body resonant vibration）It after metal film is coated with, is packaged in microchannel module, forms optical fiber detection micro flow chip, wide spectrum light source can note light to each fibre core of five core fibres respectively by five core fibre beam splitters, and when five core fibre intermediate cores note light, dumbbell fiber core carries out SPR detections；When two cores note light above and below five core fibres, dumbbell fibre cladding carries out SPR detections；When five core fibres or so, two fibre core notes light, dumbbell optical fiber duct carries out solution and inhales spectral detection, and the DNA that fluorescent material marks can also be excited to generate fluorescence signal.
Description
Technical field
The invention belongs to optical fiber micro flow chip SPR sensorgram detection fields, and in particular to a kind of dumbbell optical fiber detection is micro-
Flow chip.
Background technology
Surface plasma body resonant vibration (Surface Plasmon Resonance, SPR), belongs to a kind of physical optics phenomenon.
When incident light is incident on optically thinner medium by optically denser medium and is totally reflected, incident light and the close medium of non-immediate reflected light, but
Optically thinner medium is entered, forms evanescent wave.When, there are during tens nanometers of metal film, the evanescent wave of formation is worn between two media
Thoroughly to metal inside, the surface plasma wave to be formed is vibrated with metal inside free electron under given conditions and generates resonance,
The energy of evanescent wave can be transferred in surface plasma wave, and most of energy of incident light is absorbed, at this time in reflectance spectrum
The upper trough for forming a light intensity and drastically declining, referred to as formant.When SPR occurs, the position of formant and layer on surface of metal
The refractive index of medium is related, and when the refractive index of medium changes, formant changes therewith.Therefore, the change based on formant
Change is detected the refractive index of medium near metal film, and then realizes SPR sensorgram.SPR technique is mutually tied with biological immune technology
The surface plasmon resonance biosensor of structure is closed, is widely used in terms of biomolecule detection.SPR metal surfaces refractive index with
It attaching biomolecules quality and changes, thus the dynamic change of SPR resonance curves can reflect bio-molecular interaction
Specificity information.Such as can monitor in real time peptides, protein, oligonucleotides or even cell, virus between interact it is complete
Process.
In order to improve the detection efficiency of SPR, usually microflow control technique is combined with SPR, i.e., in surface plasmon resonance biosensor
Using micro-fluidic chip as reaction unit.It, can using micro-fluidic chip as reaction unit based on the advantage that micromation is brought
Effectively to shorten the time of detection, and reduce sample consumption.Micro-fluidic chip can with the identical structural unit of parallel arrangement,
Improve the detection flux of surface plasmon resonance biosensor.Therefore, the use of micro-fluidic chip as reaction unit is surface plasmon resonance biosensor, it is special
It is not the development trend of the surface plasmon resonance biosensor of commercialization, micro-fluidic chip-SPR technique will more in the research of medical domain
Deeply.Micro-fluidic chip is by micro-processing technology by microchannel, Micropump, micro-valve, micro- liquid storage device, microelectrode, micro- detecting element, window
The micro element that mouth and connector etc. have different function integrates, and makes micro-full analytical system.
Microfluidic analysis is the emerging analytical technology nineties.The core with micro-structure is made using micrometer-nanometer processing technology in it
Piece makes the overall processes such as the sample treatment in biochemical analysis, reaction, separation detection and data processing all concentrate on micro-fluidic
Completed on chip, it is achieved thereby that the whole micromation and automation of biochemical analysis, while can efficiently, quickly finish
Sample separating, analyzing and detecting.As it is a kind of can in the micron-scale scale manipulate liquid emerging technology, micro-fluidic chip is
It is subjected to the extensive concern of scientists.The micro flow control chip device of High Density Integration can realize the experiment of high-flux parallel
And the function integration of a variety of operating units, as a kind of new methodology platform, it has been increasingly being applied to chemistry
In the research of life science.The micro-processing technology for being presently used for making micro-fluidic chip is inherited from semi-conductor industry mostly,
Process process is various, and dependent on expensive sophisticated equipment.The common processing side in the making of micro-fluidic chip
Method includes：Silicon/polymer surfaces micro Process, soft print, coining, injection moulding, laser ablation etc..These process are required for
It is completed in ultra-clean chamber, complex procedures, big quantity space need to be occupied, and need exper ienced design and processing staff.And in miniflow
Control chip in, microfluidic control fiber chip due to it is small, detection sensitivity is high, low manufacture cost, production method letter
The features such as single, gradually attracts much attention.Traditional optical fiber micro flow chip be in embedded fibers to chip, and with it is micro-fluidic
Channel vertical processed alignment, for exciting the DNA marked in microfluidic control raceway groove with fluorescent material or amino acid to generate fluorescence
Signal.The benefit of this microfluidic control chip is：By the use of optical fiber as passing optical medium, excitation hot spot caused by optical fiber with it is micro-fluidic
Channel dimensions processed are roughly the same, improve detection sensitivity, while also eliminate bulky, expensive fluorescence microscopy
Mirror.
To sum up, the present invention proposes a kind of dumbbell optical fiber detection micro flow chip, using five cores, dumbbell, big core diameter multimode three
Kind micro-structure special optical fiber passes through optical fiber micro Process, magnetron sputtering, the making of PDMS micro flow chips and bonding techniques, manufactured light
There is fine micro flow chip multichannel SPR detections, solution to inhale the DNA marked in spectral detection, excitation microchannel with fluorescent material
Or amino acid is to generate the functions such as fluorescence signal.Compared to other micro-processing technologies, the skill of micro-fluidic chip is significantly reduced
Art threshold and processing cost have very positive meaning to the popularization and application of microfluidic chip technology.
Invention content
In view of this, the purpose of the present invention is to provide a kind of dumbbell optical fibers to detect micro flow chip, it can be achieved that dumbbell light
The multichannel SPR sensorgram of long and slender core and covering also can carry out solution in dumbbell optical fiber duct and inhale spectral detection, can also excite miniflow
The DNA or amino acid marked in channel with fluorescent material is to generate fluorescence signal.
In order to achieve the above objectives, the present invention provides following technical solution：A kind of dumbbell optical fiber detects micro flow chip, packet
Include five core fibres 1, dumbbell optical fiber 2, multimode fibre 3, microchannel module 4, wide spectrum light source 5, five core fibre beam splitters 6, spectrum
Instrument 7, micro-injection pump 8, the 1st waste liquid pool 9, computer 10；Five core fibre of wielding neck on the left of 2cm long dumbbells optical fiber, right side welding
Multimode fibre after burn into 50nm thickness SPR (surface plasma body resonant vibration) metal film is coated with, is packaged in microchannel module,
Optical fiber detection micro flow chip is formed, micro-injection pump loads solution to be measured and is tightly connected with micro flow chip injection port, miniflow core
Piece outlet connects the 1st waste liquid pool, and multimode fibre output terminal connect acquisition spr signal with spectrometer and is sent into computer disposal,
Wide spectrum light source can note light to each fibre core of five core fibres respectively by five core fibre beam splitters, when five core fibre intermediate cores note light,
Dumbbell fiber core carries out SPR detections；When two cores note light above and below five core fibres, dumbbell fibre cladding carries out SPR detections；When five
When two fibre core of core fibre or so notes light, dumbbell optical fiber duct carries out solution and inhales spectral detection, can also excite in microchannel with glimmering
The DNA or amino acid of stimulative substance label are to generate fluorescence signal.
Further, micro-structure multi-core optical fiber of five core fibres 1 for 125 μm of cladding diameter, every 6 μ of core diameter
M, 500-1000nm band of light are transmitted in the form of single mode wherein, have a 1a fibre cores 1- in the circle centre position of round covering 1-1
2, remaining four fibre core 1b cores 1-3,1c cores 1-4,1d cores 1-5,1e cores 1-6 symmetrically divide around the center of circle
Cloth.
Further, the 2nd 125 μm of the covering 2-1 diameters of dumbbell optical fiber 2, in dumbbell shape；It is substantially symmetrical about its central axis to be distributed with
The outside of two 48 μm of diameters opens the 1st duct 2-3 of duct, the 2nd duct 2-4；2nd fibre core 2-2 is located at dumbbell optical fiber center, is
Circle, 6 μm of diameter, 500-1000nm band of light are transmitted in the form of single mode wherein；
Further, the multimode fibre 3 is step-refraction index or graded index multimode fiber, and the 3rd fibre core 3-2 is straight
110 μm of diameter, the 3rd 125 μm of covering 3-1 diameters, numerical aperture 0.37；It, will be right on the left of 2cm long dumbbells optical fiber using polarization-maintaining bonding machine
Five core fibres of position welding, right side welding multimode fibre, the thin covering on hydrofluoric acid etching away dumbbell fiber core, the 2nd fibre core
It is exposed in air；Be coated with respectively in two wing passage of dumbbell core fibre of exposed 2nd fibre core with magnetron sputtering method 50nm gold or
Ag films form SPR sensorgram film；When wide spectrum optical transmits in fibre core, evanscent field is leaked in metal film, certain wavelength in evanscent field
Light and free electron motion resonance in metal, occur SPR effects.
Further, the microchannel module 4 is made of PDMS (dimethyl silicone polymer), after matrix 4-1 moldings,
Bonding packaging dumbbell optical fiber pickup probe, optical fiber probe are located in the 4-2 of main channel, and four are set into sample output passage 4-3 ends
There are sample cell or the 2nd waste liquid pool 4-4.
Further, Superk Compact model of the wide spectrum light source 5 for NKT Photonics, wave-length coverage
450-2400nm, general power are more than 100mW, and 0-100% is adjustable, single mode optical fiber output interface, and single mode is clamped with naked fibre adapter
Optical fiber output wide spectrum optical.
Further, the five core fibre beam splitters 6 be waveguide type microstructured optical fibers beam splitting device, operating wavelength range
450-2400nm can draw single mode optical fiber by five of beam splitter tail portion and note light to each fibre core of five core fibres respectively.
The beneficial effects of the present invention are：Propose a kind of dumbbell optical fiber detection micro flow chip, using five cores, dumbbell,
Big core diameter three kinds of micro-structure special optical fibers of multimode are made by optical fiber micro Process, magnetron sputtering, PDMS micro flow chips with being bonded skill
There is multichannel SPR detections, solution to inhale in spectral detection, excitation microchannel and use fluorescence for art, manufactured optical fiber micro flow chip
The DNA or amino acid of matter label are to generate the functions such as fluorescence signal.Compared to other micro-processing technologies, miniflow is significantly reduced
The technical threshold and processing cost of chip are controlled, has very positive meaning to the popularization and application of microfluidic chip technology.When five
When core fibre intermediate core notes light, dumbbell fiber core carries out SPR detections, since dumbbell fiber core is single mode, with conventional multi-mode
Optical fiber sensor is compared, and since transmission mode only has basic mode, has high average sensitivity；Two above and below five core fibres
When core notes light, dumbbell fibre cladding carries out SPR detections, and forming multichannel SPR with fibre core SPR sensorgram channel senses, at algorithm
Reason, can effectively reject non-specific response；When five core fibres or so, two fibre core notes light, dumbbell optical fiber duct carries out solution suction
Spectral detection can also excite the DNA marked in microchannel with fluorescent material or amino acid to generate fluorescence signal.
Description of the drawings
In order to make the purpose of the present invention, technical solution and advantageous effect clearer, the present invention provides drawings described below and carries out
Explanation：
Fig. 1 is the whole composition schematic diagram of the present invention；
Fig. 2 is micro-machined optical fiber pickup probe structure diagram；
Fig. 3 is AA ', BB ', the corresponding sectional view of CC ' planes in Fig. 2, wherein figure (a) is five core fibre sectional views, it is corresponding
In AA ' planes；It is dumbbell fibre profile figure to scheme (b), corresponding to BB ' planes；It is multimode fibre sectional view to scheme (c), is corresponded to
CC ' planes；
Fig. 4 is PDMS microchannel module channels schematic diagrames.
Specific embodiment
Below in conjunction with attached drawing, the preferred embodiment of the present invention is described in detail.
A kind of dumbbell optical fiber detects micro flow chip：As shown in Fig. 2, one section of dumbbell optical fiber of interception, a length of 10cm, at it
One end divests coat 3cm with blade, and it is clean to dip alcohol wipe with optical fiber cleansing tissue, and using optical fiber cutter by its end face
It cuts smooth；One section of five core fibre is intercepted, a length of 1m divests coat 3cm with blade at one end, wine is dipped with optical fiber cleansing tissue
Smart wiped clean, and it is using optical fiber cutter that its ends cutting is smooth；The dumbbell optical fiber handled well and five core fibres are loaded on
In polarization maintaining optical fibre bonding machine, two optical fiber position up and down is controlled, the fibre core of five core fibres is made to be aligned with dumbbell fiber core,
Two fiber spinnings are controlled, the left and right fibre core of five core fibres is made to be aligned with two duct of dumbbell optical fiber, and are welded using low discharging current
It connects, prevents optical fiber duct from deforming.After the completion of welding machine, under the microscope, cut away dumbbell optical fiber with optical fiber cutter and do not divest coating
Layer side, it is 2cm to make to be welded on the naked dumbbell fiber lengths on five core fibres.Multimode fibre is divested into coat, after cutting is smooth,
Dumbbell optical fiber other side is welded on, it is preliminary to form microstructured optical fibers probe structure shown in Fig. 2.Fig. 3 is that AA ', BB ' are flat in Fig. 2
The corresponding sectional view in face, wherein figure (a) is five core fibre sectional views, corresponding to AA ' planes, five core fibres 1 are cladding diameter 125
μm micro-structure multi-core optical fiber, every 6 μm of core diameter, 500-1000nm band of light wherein in the form of single mode transmit, in circle
The circle centre position of shape covering 1-1 has a 1a fibre core 1-2, remaining four fibre core 1b cores 1-3,1c cores 1-4,1d lines
Core 1-5,1e cores 1-6 are symmetrical around the center of circle；It is dumbbell fibre profile figure to scheme (b), corresponding to BB ' planes, dumbbell light
Fine 2 the 2nd 125 μm of covering 2-1 diameters, in dumbbell shape, the outside substantially symmetrical about its central axis that 48 μm of two diameter is distributed with opens duct the 1st
Duct 2-3, the 2nd duct 2-4, the 2nd fibre core 2-2 are located at dumbbell optical fiber center, for circle, 6 μm of diameter, 500-1000nm band of light
It is transmitted in the form of single mode wherein；Scheme (c) be multimode fibre sectional view, multimode fibre 3 be step-index multimode fiber, the 3rd
110 μm of fibre core 3-2 diameters, the 3rd 125 μm of covering 3-1 diameters, numerical aperture 0.37.
The microstructured optical fibers probe tentatively to complete is immersed in 75% hydrofluoric acid solution, corrodes 0.5min, gets rid of
The thin covering on dumbbell fiber core surface；It is cleaned with distilled water, removes hydrofluoric acid remaining on microstructured optical fibers probe, drying
After be put into plasma cleaner and clean 5min；Side duct is upward under the microscope for microstructured optical fibers probe after handling well
It is fixed on glass slide, is put in below magnetic control sputtering device gold target, is coated with 50nm golden films, then dumbbell fiber core side is coated with
The SPR sensorgram golden film of 50nm thickness；After the completion of being coated with, glass slide is fixed in dumbbell optical fiber opposite side duct upwards under the microscope
On, it is positioned over below magnetic control sputtering device silver target, is coated with 50nm golden films, then dumbbell fiber core opposite side has been coated with 50nm thickness
SPR sensorgram golden film.When injecting wide spectrum light source in dumbbell fiber core, since covering is corroded removal, evanscent field directly with it is upper
Lower both sides golden film acts on, certain wavelength light and free electron vibration resonance in golden film, occur SPR effects in evanescent wave.
As shown in figure 4, make microchannel module 4 with PDMS, after matrix 4-1 moldings, micro- knot that bonding packaging processes
Structure optical fiber pickup probe completes the making of optical fiber detection micro flow chip.Optical fiber probe is located in the 4-2 of main channel, two
Sample intake passage 4-3 ends are provided with sample cell, and two sample output passage ends are provided with the 2nd waste liquid pool 4-4.
The overall work system of the present invention on the right side of the optical fiber to complete detection micro flow chip as shown in Figure 1, by accessing
Spectrometer 7, spectrometer collection data are sent into computer 10 and are handled；Left side super continuum source 5 is divided by five core fibre beam splitters 6
Not Gei each fibre core of five core fibres note light, micro-injection pump 8 loads and detects micro flow chip by pipeline and optical fiber after solution to be measured
Sample cell connection sealing can inject solution to be measured to the two any channels of optical fiber microchannel, optical fiber detection micro flow chip the 1st
Waste liquid pool passage catheter is sealingly connected to the 2nd waste liquid pool.When five core fibre intermediate cores note light, dumbbell fiber core carries out SPR
Detection, since dumbbell fiber core is single mode, compared with legacy multimode fiber spr sensor, since transmission mode only has basic mode,
With high average sensitivity；When two cores note light above and below five core fibres, dumbbell fibre cladding carries out SPR detections, with fibre core
SPR sensorgram channel forms multichannel SPR sensorgram, through algorithm process, can effectively reject non-specific response；When a five core fibres left side
During right two fibre cores note light, dumbbell optical fiber duct carries out solution and inhales spectral detection, can also excite in microchannel with fluorescent material mark
The DNA or amino acid of note are to generate fluorescence signal.
Finally illustrate, preferred embodiment above is merely illustrative of the technical solution of the present invention and unrestricted, although logical
It crosses above preferred embodiment the present invention is described in detail, however, those skilled in the art should understand that, can be
Various changes are made to it in form and in details, without departing from claims of the present invention limited range.
Claims (7)
1. a kind of dumbbell optical fiber detects micro flow chip, including five core fibres（1）, dumbbell optical fiber（2）, multimode fibre（3）, it is micro-
Circulation road module（4）, wide spectrum light source（5）, five core fibre beam splitters（6）, spectrometer（7）, micro-injection pump（8）, the 1st waste liquid pool
（9）, computer（10）；Five core fibre of wielding neck on the left of 2cm long dumbbells optical fiber, right side welding multimode fibre, through burn into 50nm thickness
It after SPR metal films are coated with, is packaged in microchannel module, forms optical fiber detection micro flow chip, micro-injection pump loading is treated
It surveys solution to be tightly connected with micro flow chip injection port, micro flow chip outlet connects the 1st waste liquid pool, multimode fibre output terminal and light
Spectrometer connection acquisition spr signal is simultaneously sent into computer disposal, and wide spectrum light source can give five core light respectively by five core fibre beam splitters
Fine each fibre core note light, when five core fibre intermediate cores note light, dumbbell fiber core carries out SPR detections；Two above and below five core fibres
When core notes light, dumbbell fibre cladding carries out SPR detections；When five core fibres or so, two fibre core notes light, dumbbell optical fiber duct carries out
Solution inhales spectral detection, and the DNA marked in microchannel with fluorescent material or amino acid can also be excited to generate fluorescence signal.
2. a kind of dumbbell optical fiber detection micro flow chip according to claim 1, it is characterised in that：The five core light
It is fine（1）For 125 μm of micro-structure multi-core optical fiber of cladding diameter, every 6 μm of core diameter, 500-1000nm band of light wherein with
Single mode form is transmitted, in round covering（1-1）Circle centre position have a 1a fibre core（1-2）, remaining four fibre core is around the center of circle
It is symmetrical.
3. a kind of dumbbell optical fiber detection micro flow chip according to claim 1, it is characterised in that：The dumbbell light
It is fine（2）2nd covering（2-1）125 μm of diameter, in dumbbell shape；The outside open bore substantially symmetrical about its central axis that 48 μm of two diameter is distributed with
Road；2nd fibre core（2-2）Positioned at optical fiber center, for circle, 6 μm of diameter, 500-1000nm band of light is passed in the form of single mode wherein
It is defeated.
4. a kind of dumbbell optical fiber detection micro flow chip according to claim 1, it is characterised in that：The multimode light
It is fine（3）For step-refraction index or graded index multimode fiber, the 3rd fibre core（3-2）110 μm of diameter, the 3rd covering（3-1）Diameter
125 μm, numerical aperture 0.37；Using polarization-maintaining bonding machine, by five core fibre of wielding neck on the left of 2cm long dumbbells optical fiber, right side weldering
Connect multimode fibre, the thin covering on hydrofluoric acid etching away dumbbell fiber core, the 2nd fibre core is exposed in air；It is splashed with magnetic control
It penetrates method and is coated with 50nm gold or Ag films respectively in two wing passage of dumbbell core fibre of exposed 2nd fibre core, form SPR sensorgram film；
When wide spectrum optical transmits in fibre core, evanscent field is leaked in metal film, certain wavelength light is transported with free electron in metal in evanscent field
Dynamic resonance, occurs SPR effects.
5. a kind of dumbbell optical fiber detection micro flow chip according to claim 1, it is characterised in that：The miniflow leads to
Road module（4）It is made of PDMS, matrix（4-1）After molding, bonding packaging dumbbell optical fiber pickup probe, optical fiber probe is located at
Main channel（4-2）In, four into sample output passage（4-3）End is provided with sample cell or the 2nd waste liquid pool（4-4）.
6. a kind of dumbbell optical fiber detection micro flow chip according to claim 1, it is characterised in that：The wide spectrum optical
Source（5）For the Superk Compact models of NKT Photonics, wave-length coverage 450-2400nm, general power is more than 100mW,
0-100% is adjustable, single mode optical fiber output interface, with naked fibre adapter clamping single mode optical fiber output wide spectrum optical.
7. a kind of dumbbell optical fiber detection micro flow chip according to claim 1, it is characterised in that：The five core light
Fine beam splitter（6）For waveguide type microstructured optical fibers beam splitting device, operating wavelength range 450-2400nm can pass through beam splitter tail portion
Five draw single mode optical fibers and give each fibre core of five core fibres note light respectively.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107884367A (en) * | 2017-10-12 | 2018-04-06 | 重庆三峡学院 | A kind of dumbbell optical fiber detects micro flow chip |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107884367A (en) * | 2017-10-12 | 2018-04-06 | 重庆三峡学院 | A kind of dumbbell optical fiber detects micro flow chip |
| CN107884367B (en) * | 2017-10-12 | 2023-09-22 | 重庆三峡学院 | Dumbbell optical fiber SPR (surface plasmon resonance) detection microfluidic chip |
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