CN207483715U - Round bottom matches liquid bag - Google Patents

Round bottom matches liquid bag Download PDF

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Publication number
CN207483715U
CN207483715U CN201721277845.0U CN201721277845U CN207483715U CN 207483715 U CN207483715 U CN 207483715U CN 201721277845 U CN201721277845 U CN 201721277845U CN 207483715 U CN207483715 U CN 207483715U
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China
Prior art keywords
bag
round bottom
liquid bag
interface
matches liquid
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CN201721277845.0U
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Chinese (zh)
Inventor
秦孙星
刘志
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SHANGHAI LEPURE BIOTECH Co.,Ltd.
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Shanghai Duoning Biological Technology Co Ltd
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Abstract

The utility model is related to round bottoms to match liquid bag, it is characterized in that, bottom surface, top surface and lateral parts of the round bottom with liquid bag are formed by film, the lateral parts enclose cylinder bag body (1) by rectangle, the round bottom further includes the magnetic stirring apparatus (4) positioned at bottom surface, the first interface (2) positioned at top and bottom and second interface (3), woven hose, sampling bag with liquid bag, wherein, first interface (2) is for connecting the woven hose, and second interface (3) is for connecting the sampling bag.The utility model can be conveniently used in the liquid liquid mixing of various volumes (such as 200L, 500L, 1000L), liquid mixes admittedly, the different areas of activity of mixing.

Description

Round bottom matches liquid bag
Technical field
The utility model is related to be used to the mixing plant technical field of biological respinse more particularly to disposable magnetic agitation mix Even system matches liquid bag more particularly, to round bottom.
Background technology
In the prior art, especially in medicine production, disposable system is grown rapidly with imitation medicine market The concern and application of numerous pharmacy corporations are arrived.Disposable system typical case includes bioreactor, including being used for The reactor used in fermentation, enzymatic reaction, cell culture.These application scenarios require extremely harsh technical indicator and technique Step, which greatly improves operating costs.
Wherein, Typical Representative of the blending system as disposable system has obtained the consistent accreditation of pharmacy corporation.It is mixed Even system is usually made of two parts, one is disposable plastic bag part, by plastic bag, pipeline, connector, filtering The part such as device forms;The second is reusable support and power-equipment, by barrel support, castor pedestal, servo motor, weigh The part such as module, control panel forms.The major function of blending system is culture medium configuration, buffer solution is configured, product pH is adjusted, Intermediate product mixing, virus inactivation technology, finished product configuration etc..
Disposable magnetic agitation blending system can be that many links in medicine intermediate and the production of finished product sterile preparation carry For advanced stirring technique, and many solution can be used for and prepared, such as buffer solution and culture medium etc., applicability is very extensive, fits Together in the application of different sanitary grades.
Common blender platform is cylindrical (tubbiness), therefore is using round bottom shape and structure with liquid bag with what it coordinated Preferably.For bio-pharmaceuticals technique, round bottom bag advantageously reduces resid vol, still, since thin-film material is very hard, lacks bullet Property, the design and manufacture of round bottom bag have great difficulty.In addition, common, with liquid bag, there is also small size blending process, liquid-solid difficulties The problems such as molten technique, for example, calcium carbonate granule needs to can be only achieved mixed effect in the case where ceaselessly stirring, if stopping shaking The phenomenon that will appear precipitation, being precipitated.
Utility model content
For this purpose, in view of drawbacks described above, for the inventor of the utility model by concentrating on studies and designing, synthesis is long-term for many years The experience and achievement of related industry are engaged in, research and design goes out a kind of round bottom that disposable magnetic agitation blending system is suitble to use and matches Liquid bag, for bio-pharmaceuticals technique, round bottom bag advantageously reduces resid vol, but the design of round bottom bag and manufacture all extremely have Difficulty, mainly film are very hard, lack flexibility, and therefore, inventor has been especially tailored mold and has been manufactured to complete round bottom with liquid bag.
Embodiment according to the present utility model provides a kind of round bottom with liquid bag, which is characterized in that is formed by film described Round bottom matches bottom surface, top surface and the lateral parts of liquid bag, and the lateral parts enclose cylinder bag body, the round bottom by rectangle The magnetic stirring apparatus positioned at bottom surface, the first interface positioned at top and bottom and second interface are further included with liquid bag, woven hose, are taken Sample bag, wherein, for connecting the woven hose, second interface is used to connect the sampling bag first interface.
Embodiment according to the present utility model, the round bottom further include magnetic force separation sleeve with liquid bag, are arranged at described Magnetic stirring apparatus lower part, for the magnetic stirring apparatus to be isolated with bottom surface of the round bottom with liquid bag.
Embodiment according to the present utility model, the first interface are multiple first interfaces, are located at the round bottom respectively Top and bottom with liquid bag.
Embodiment according to the present utility model, the bottom magnetic force separation sleeve is annular in shape, for making the magnetic stirring apparatus It passes through.
Embodiment according to the present utility model, the bag body and the sampling bag by five-layer coextrusion transfusion film production and Into the material of five-layer coextrusion transfusion film is polyethylene.
Embodiment according to the present utility model, the bag body are made up of heat seal mode, and the bottom surface and summit portion are each It is engaged respectively with the lateral parts from by multiple isometric welding items.
Embodiment according to the present utility model, the bag body with the magnetic force separation sleeve by being welded to connect, the magnetic force The material of separation sleeve is polypropylene.
Embodiment according to the present utility model, the magnetic stirring apparatus include three leaf paddles and rotary magnet, are loaded into jointly The drop-center of the magnetic force separation sleeve.
Embodiment according to the present utility model, first and second interface is soldering opening, is respectively used to and the infusion Soldering opening welding on pipe and the sampling bag.
Embodiment according to the present utility model, the woven hose are equipped with soldering opening, band, hose clamp, twin adapter, Rule and connect Head, quick coupling, soldering opening pipe, sampling bag, long stainless steel ring.
By above structure it is found that the utility model has the advantages that:
1st, the Liquid-liquid mixing of various volumes (such as 200L, 500L, 1000L) can be conveniently used in, liquid-solid mixing, mixed Even different areas of activity;
2nd, blade in polybag is driven to move using magnetic driver mode, reaches preferable magnetic agitation effect;
3rd, it is reduced friction loss using plastic disc come servo motor outside agitating paddle in fixing bag and bag;
4th, can be integral with paddle-shaped made of plastics after the magnetite plastic overmold, the blade can take three pieces paddle The design form of leaf, the inclination of each blade certain angle advantageously reduce the shearing force of paddle belt in this way.
The detailed content of the utility model can be obtained by aftermentioned explanation and institute's attached drawing.
Description of the drawings
Fig. 1 is the external structure schematic diagram for matching liquid bag according to the round bottom of the embodiment of the utility model;
Fig. 2 shows the schematic diagram of stirring platform according to the present utility model.
Reference numeral in attached drawing is as follows:
1st, bag body;2、3:Interface;4th, blender;5th, pedestal;6th, platform hull is stirred.
Specific embodiment
In the following, the implementation of technical solution is described in detail as example with reference to attached drawing.
It will be appreciated by those of skill in the art that although the following description is related to the embodiment in relation to the utility model Many technical details, but be only for the example of principle for illustrating the utility model and do not mean that any restrictions.This practicality It is novel to be suitable for being different from the occasion except technical detail exemplified below, without departing from the original of the utility model Reason and spirit.
It, may pair can be in description in the present specification in addition, tedious in order to avoid being limited to the description of this specification The portion of techniques details obtained in prior art data has carried out the processing such as omission, simplification, accommodation, this is for the technology of this field It will be understood by for personnel, and this does not interfere with the open adequacy of this specification.
Fig. 1 is the schematic diagram for matching liquid bag according to the round bottom of the embodiment of the utility model, by taking the volume of 200L as an example.
As shown in Figure 1, inventor has made tooling to complete the manufacture of round bottom bag.In order to ensure the versatility of equipment, can adopt The welding item for being 30cm with unilateral length, for example, the sack of 200L is made of 6 sides, the sack of 500L is made of 8 sides, 1000L Sack be made of 10 sides, side is made of two panels rectangular film, size for example be respectively 144cm × 100cm.By accurate Cut out film, it is ensured that merging precision, to complete docking for top and bottom and side in figure.In use, by the tension force effect of film, It bottom surface can be due to compression in approximate circle.
In addition, round bottom as shown in Figure 1 matches liquid bag, including bag body 1, bottom magnetic stirring apparatus (such as three leaf paddles) 4, bottom Magnetic force separation sleeve, sampling bag (not shown) and multiple woven hose (not shown);The bag body is for cylinder and equipped with multiple connections Mouthful.
The bag body 1 is for cylinder and equipped with multiple soldering openings;Woven hose is connect with the soldering opening on bag body, and soldering opening is Circle interface can preferably connect with woven hose, can be effectively prevented leakage;Bottom magnetic force separation sleeve and bag body 1 Bottom surface be welded to connect, magnetic force three leaf paddle in bottom is packed into the groove of the bottom magnetic force separation sleeve;Bag body 1 is by thin film fabrication, easily It in folding, occupies little space, convenient for storage, equipped with multiple woven hoses, energy plug and play is easy to use.
Bag body 1 is formed by five-layer coextrusion transfusion with film production, and material is polyethylene, health safe to use.In this example, Leakproofness is made by heat seal mode in bag body 1, which will not generate pollutant;Bag body 1 is cylinder, and bottom is by 8 Since the character of bottom surface is irregular, higher requirement is proposed to cutting out film for 30 centimetres of welding item composition.It can be according to not androgynous Long-pending round bottom stirring bag design welding quantity.
In this example, woven hose has 5 bye-passes, and each woven hose, by being welded to connect, prevents leakage from showing with soldering opening As occurring;The material of woven hose is medical silica-gel, and silica gel has good biocompatibility, is a kind of inert material of quite stable Matter;Energy high temperature resistant, can sterilize, easy to use.
Bottom magnetic force separation sleeve is welded to connect with bag body, is connected firmly, to prevent the phenomenon of leakage;Three leaf of bottom magnetic force Paddle is packed into the groove of the bottom magnetic force separation sleeve, and the card slot on the magnetic force separation sleeve of bottom firmly blocks three leaf paddle of bottom magnetic force Firmly, without departing from bottom magnetic force separation sleeve during stirring operation.The material of three leaf paddle of bottom magnetic force be neodymium iron boron kicker magnet inner core and Polypropylene shell and cylindrical disposable magnetic agitation blending system match, inductively can be effective by magnetic motor Realize solid-liquid and liquid liquid mixing.
In this example, the woven hose be equipped with soldering opening, band, hose clamp, twin adapter, female Luer, quick coupling, Soldering opening pipe, sampling bag, long stainless steel ring.
The structure of the utility model is summarized below.
A kind of round bottom is provided with liquid bag, bottom surface, top surface and lateral parts of the round bottom with liquid bag, institute are formed by film State lateral parts and cylinder bag body enclosed by rectangle, the round bottom with liquid bag further include the magnetic stirring apparatus positioned at bottom surface, First interface and second interface, woven hose, sampling bag positioned at top and bottom, wherein, first interface is described defeated for connecting Liquid pipe, second interface are used to connect the sampling bag
As an example, the bottom magnetic force separation sleeve is annular in shape, 4 lower part of bottom magnetic stirring apparatus is arranged at, for inciting somebody to action Bottom magnetic stirring apparatus is isolated with interior bottom of the round bottom with liquid bag, is played a protective role to bottom magnetic stirring apparatus.
The woven hose is connect with by being located at interface 2 of the round bottom with the first specification at the top of liquid bag with round bottom with liquid bag.
The sampling bag is connect by being located at the interface 3 of the second specification of the round bottom with liquid bag bottom with round bottom with liquid bag.
As an example, the bag body 1 and the sampling bag are formed by five-layer coextrusion transfusion with film production.The five-layer co-squeezing The material of film for transfusion is polyethylene.
As an example, the bag body is made up of heat seal mode.
As an example, the bag body with the bottom magnetic force separation sleeve by being welded to connect.
As an example, the material of the bottom magnetic force separation sleeve is polypropylene.
As an example, the three leaf paddle of bottom magnetic force is packed into the groove of the bottom magnetic force separation sleeve.
As an example, the material of the three leaf paddle of bottom magnetic force is neodymium iron boron kicker magnet inner core and polypropylene shell.
As an example, the interface 2 and 3 is soldering opening, the woven hose passes through welding with the soldering opening on the bag body Connection.
As an example, the material of the woven hose is medical silica-gel.
As an example, the woven hose is equipped with soldering opening, band, hose clamp, twin adapter, female Luer, quick coupling, weldering Mouthpiece, sampling bag, long stainless steel ring.
As an example, the material of the band and the hose clamp is nylon.
As an example, the interface 2 and 3, the twin adapter, the female Luer, the quick coupling, the soldering opening The material of pipe is polypropylene.
As an example, the material of the long stainless steel ring is stainless steel.
Round bottom can be matched with liquid bag with cylindrical disposable magnetic agitation blending system, plug and play, user Just, resid vol can be favorably reduced, solid-liquid and liquid liquid mixing inductively can effectively be realized by magnetic motor.
Fig. 2 shows the schematic diagram of stirring platform according to the present utility model.
As shown in Fig. 2, the blender 4 can be magnetic stirring apparatus, it includes the multi-discs stretched into stirring platform hull 6 Blade and the magnetite below multi-disc blade, the lower section of the magnetite are equipped with servo drive motor, the servo-drive electricity Airborne device is there are one the driving magnetite identical with the magnetite magnetism and structure, so as to when servo drive motor drives and rotates Blade in polybag is driven to move using magnetic driver mode, to reach preferable magnetic agitation effect.
As an example, using a plastic disc come servo motor outside agitating paddle in fixing bag and bag, the plastic disc The effect that round bottom matches liquid bag of reinforcing is also acted as, can be matched on liquid bag in round bottom by thermal weld, the driving on the servo drive motor There is the gap less than or equal to 1mm between magnetite and plastic disc, the purpose done so is also to reduce friction.
Can be integral with paddle-shaped made of plastics after the magnetite plastic overmold, the blade can take three pieces blade Design form, the inclination of each blade certain angle advantageously reduces the shearing force of paddle belt in this way.
The magnetite uses circular ring shape permanent magnet, ensures the homogeneity of dynamics during rotation, and the outer surface of magnetite, which can be equipped with, to be added Strong fixed groove, for fixed magnetite and blade.
Finally, it will be appreciated by those of skill in the art that various repair can be made to above-described embodiment of the utility model Change, modification and replace, each fall within the scope of protection of the utility model as defined in the appended claims.

Claims (10)

1. a kind of round bottom matches liquid bag, which is characterized in that forms bottom surface, top surface and side surface part of the round bottom with liquid bag by film Point, the lateral parts enclose cylinder bag body (1) by rectangle,
The round bottom with liquid bag further include the magnetic stirring apparatus (4) positioned at bottom surface, the first interface (2) positioned at top and bottom and Second interface (3), woven hose, sampling bag,
Wherein, first interface (2) is for connecting the woven hose, and second interface (3) is for connecting the sampling bag.
2. round bottom according to claim 1 matches liquid bag, it is characterised in that further includes magnetic force separation sleeve, is arranged at described Magnetic stirring apparatus (4) lower part, for the magnetic stirring apparatus (4) to be isolated with bottom surface of the round bottom with liquid bag.
3. round bottom according to claim 1 matches liquid bag, which is characterized in that the first interface (2) is multiple first interfaces (2), it is located at the top and bottom that the round bottom matches liquid bag respectively.
4. round bottom according to claim 2 matches liquid bag, which is characterized in that the magnetic force separation sleeve is annular in shape, for making Magnetic stirring apparatus (4) is stated to pass through.
5. round bottom according to claim 1 matches liquid bag, which is characterized in that the bag body (1) and the sampling bag are by five layers Co-squeeze film for transfusion is made, and the material of five-layer coextrusion transfusion film is polyethylene.
6. round bottom according to claim 1 matches liquid bag, which is characterized in that the bag body (1) is made up of heat seal mode, institute Bottom surface and summit portion is stated to engage with the lateral parts respectively each by multiple isometric welding items.
7. round bottom according to claim 2 matches liquid bag, which is characterized in that the bag body (1) is led to the magnetic force separation sleeve It crosses and is welded to connect, the material of the magnetic force separation sleeve is polypropylene.
8. round bottom according to claim 2 matches liquid bag, which is characterized in that the magnetic stirring apparatus (4) including three leaf paddles and Rotary magnet is loaded into the drop-center of the magnetic force separation sleeve jointly.
9. round bottom according to claim 1 matches liquid bag, which is characterized in that first and second interface (2,3) is welding Mouthful, it is respectively used to weld with the soldering opening on the woven hose and the sampling bag.
10. round bottom according to claim 1 matches liquid bag, which is characterized in that the woven hose is equipped with soldering opening, band, soft Pipe clamp, twin adapter, female Luer, quick coupling, soldering opening pipe, sampling bag, long stainless steel ring.
CN201721277845.0U 2017-09-30 2017-09-30 Round bottom matches liquid bag Active CN207483715U (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201721277845.0U CN207483715U (en) 2017-09-30 2017-09-30 Round bottom matches liquid bag

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201721277845.0U CN207483715U (en) 2017-09-30 2017-09-30 Round bottom matches liquid bag

Publications (1)

Publication Number Publication Date
CN207483715U true CN207483715U (en) 2018-06-12

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ID=62479383

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201721277845.0U Active CN207483715U (en) 2017-09-30 2017-09-30 Round bottom matches liquid bag

Country Status (1)

Country Link
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114011305A (en) * 2021-11-29 2022-02-08 上海偲瑞生物医药有限公司 Disposable stirring system and method

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114011305A (en) * 2021-11-29 2022-02-08 上海偲瑞生物医药有限公司 Disposable stirring system and method

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Legal Events

Date Code Title Description
GR01 Patent grant
GR01 Patent grant
EE01 Entry into force of recordation of patent licensing contract
EE01 Entry into force of recordation of patent licensing contract

Assignee: SHANGHAI LEPURE BIOTECH Co.,Ltd.

Assignor: SHANGHAI DUONING BIOTECHNOLOGY CO.,LTD.

Contract record no.: 2019310000036

Denomination of utility model: Liquid bag is joined in marriage to round bottom

Granted publication date: 20180612

License type: Exclusive License

Record date: 20190429

TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20201209

Address after: Room 203-6, building 11, No. 518, shenzhuan Road, Songjiang hi tech park, Shanghai Caohejing Development Zone, Songjiang District, Shanghai, 201601

Patentee after: SHANGHAI LEPURE BIOTECH Co.,Ltd.

Address before: Building 30, No. 1525, Minqiang Road, Songjiang District, Shanghai, 201612

Patentee before: SHANGHAI DUONING BIOTECHNOLOGY Co.,Ltd.

IP01 Partial invalidation of patent right
IP01 Partial invalidation of patent right

Commission number: 5W129041

Conclusion of examination: Declare claims 1-5 and 7-10 of utility model number 201721277845.0 invalid, and continue to maintain the validity of the patent on the basis of claim 6

Decision date of declaring invalidation: 20230301

Decision number of declaring invalidation: 210001

Denomination of utility model: Round bottom dispensing bag

Granted publication date: 20180612

Patentee: SHANGHAI LEPURE BIOTECH Co.,Ltd.