CN207286342U - A kind of polymer overmold Nano medication preparation facilities - Google Patents
A kind of polymer overmold Nano medication preparation facilities Download PDFInfo
- Publication number
- CN207286342U CN207286342U CN201720158673.9U CN201720158673U CN207286342U CN 207286342 U CN207286342 U CN 207286342U CN 201720158673 U CN201720158673 U CN 201720158673U CN 207286342 U CN207286342 U CN 207286342U
- Authority
- CN
- China
- Prior art keywords
- fibre bundle
- peristaltic pump
- crystallizer
- inner tube
- outlet
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Landscapes
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
A kind of polymer overmold Nano medication preparation facilities, is related to the preparation of Nano medication.Polymer overmold Nano medication preparation facilities, which is equipped with, divides solvent bottle, the 1st peristaltic pump, fibre bundle crystallizer, dissolving apothecary jar, the 2nd peristaltic pump and vacuum filtering system；The fibre bundle crystallizer is equipped with outer tube and inner tube, inner tube is located in outer tube, solvent bottle is divided to be connected with the entrance of the 1st peristaltic pump, the outlet of 1st peristaltic pump is connected with the inner tube inlet of fibre bundle crystallizer, the inner tube outlet closure of fibre bundle crystallizer, dissolving apothecary jar is connected with the entrance of the 2nd peristaltic pump, and the outlet of the 2nd peristaltic pump is connected with the outer tube inlet of fibre bundle crystallizer, and the outer tube outlet of fibre bundle crystallizer connects vacuum filtering system；The inner tube of the fibre bundle crystallizer is made of hollow porous fiber tow.
Description
Technical field
The preparation of Nano medication is the utility model is related to, micron order hollow porous fiber tow is utilized more particularly, to one kind
A kind of polymer overmold Nano medication preparation facilities of crystallizer.
Background technology
In recent years, with the continuous development of nanosecond science and technology, the nano-drug preparation that is formed based on nanometer technology research and development it is only
Property values are also gradually understood by researcher, such as passive targeting, enhancing infiltration retention effect etc..But directly use nanometer medicine
Thing crystal is difficult to be applied directly in actual therapeutic because of a variety of causes, often just by body before human body active component is not reached
Macrophage identification in interior immune system swallows up and fails.Using degradable polymer (such as PLGA, PEG etc.) to nanometer
Polymer nanocomposite made of grain cladding, which carries medicine particle, many advantages：Drug effectiveness can be such as improved, release time is controlled, prolongs
Long medicine biological half-life, is more easy to through cell membrane etc..Therefore how by medicament nano, and cladding is carried out to its surface and is repaiied
Decorations become a popular research problem for being badly in need of solving.At this stage, Many researchers take distinct methods pair from every field
Nano medication is prepared and polymer overmold.Such as Azad ([1] Azad M, Arteaga C, Abdelmalek B, et
al.Spray drying of drug-swellable dispersant suspensions for preparation of
fast-dissolving,high drug-loaded,surfactant-free nanocomposites.Drug
Development and Industrial Pharmacy,2015,41(10):1-15) will first by wet method nanon ball-mill
Medicine griseofulvin (Griseofulvin) is prepared into a nanometer suspension, then adds polymer and surfactant, utilizes spray
The cladding drying of Nano medication suspension is become polymer nanocomposite composite particles by mist dry technology；([2] the Li J, Hwang I such as li
C,Chen X,et al.Effects of chitosan coating on curcumin loaded nano-emulsion:
Study on stability and invitrodigestibility.Food Hydrocolloids,2016,60:138-
147) the nanometer emulsified methods of O/W are utilized, first medicine is dispersed in oil-based system, then is instilled in the acetic acid solution of chitosan simultaneously
Emulsified using ultrasound, be prepared into the nano particle suspension of polymer overmold；([3] Paisana M C, the M ü such as Paisana
llers K C,Wahl M A,et al.Production and Stabilization of Olanzapine
Nanoparticles by Rapid Expansion of Supercritical Solutions(RESS).Journal of
Supercritical Fluids the,2015,109(1):124-13) using super-critical rapid expansion method (RESS) in high temperature
Supercritical CO is used under high pressure2Prepare Nano medication particle.But these method for coating all there are problems that.Based on O/W's
Nanometer emulsified method easily in preparation process due to nano particle peculiar property (high-ratio surface energy, strong Van der Waals force) and
Produce soft-agglomerated phenomenon in solution, the polymer overmold of production live multiple nano particles and caused by hard aggregation can not be separated；
Supercritical CO2Technology is then because the low solubility of polymer or drug particles causes the large-scale production of medicine to be restricted；Spraying
Dry technology needs the high energy consumption condition such as high temperature, and restricted to the nanometer particle size of preparation, it is difficult to prepare less than 10nm
Grain；And most of preparation method is all batch production (batch process) at this stage, causes production efficiency low, often
A batch of quality is uneven, it is difficult to carries out Effective Regulation in practical application.Therefore how successional grain is produced
Spend controllable, reaction condition is gentle and the polymer overmold Nano medication particle of stable quality becomes the emphasis studied at present and difficulty
Point.
The content of the invention
The purpose of this utility model is to provide a kind of polymer using micron order hollow porous fiber tow crystallizer
Coat Nano medication preparation facilities.
The utility model, which is equipped with, divides solvent bottle, the 1st peristaltic pump, fibre bundle crystallizer, dissolving apothecary jar, the 2nd peristaltic pump
And vacuum filtering system；The fibre bundle crystallizer is equipped with outer tube and inner tube, and inner tube is located in outer tube, divides solvent bottle and the 1st
The entrance connection of peristaltic pump, the outlet of the 1st peristaltic pump are connected with the inner tube inlet of fibre bundle crystallizer, fibre bundle crystallizer
Inner tube outlet closure, dissolving apothecary jar be connected with the entrance of the 2nd peristaltic pump, the outlet of the 2nd peristaltic pump and fibre bundle crystallization
The outer tube inlet connection of device, the outer tube outlet of fibre bundle crystallizer connect vacuum filtering system；The fibre bundle crystallizer
Inner tube is made of hollow porous fiber tow.
It can set the 1st pressure gauge between the outlet of 1st peristaltic pump and the inner tube inlet of fibre bundle crystallizer, described
The 2nd pressure gauge can be set between the outlet of 2 peristaltic pumps and the outer tube inlet of fibre bundle crystallizer；Single hollow porous fiber silk
Porosity can be 80%.
Compared with existing polymer overmold Nano medication preparation facilities, the utility model has the advantages that following prominent：
1) particle diameter and polymer overmold layer thickness of Nano medication are accurately controlled：Micron order doughnut tow is special because of its
Tectonic property can provide the microenvironment needed beneficial to crystallization.The pore (being more than 80% porosity) of wherein porous fibre silk causes greatly
Amount introduction point can provide uniform radial direction Mixed Zone for divide solvent by the mixing with organic solution.For dividing solvent to guide
Precipitation process, the quick mixed process between two fluids affects the local degree of supersaturation of precipitation zone, and efficiently accurate
Mixed process can cause explosive nucleation and make homoepitaxial after crystal nucleation, so as to reach accurate control nanocrystal particle diameter
With the purpose of coating thickness (10nm).
2) the fibre bundle crystallizer that the utility model uses is a kind of continuous type crystallizer, inside fibre bundle crystallizer
React for continuous type reaction process, can in time can by regulating and controlling response parameter integration production particle diameter for being produced compared to batch
The polymer nanocomposite medicine crystal of control, is conducive to increase yield with controlling product quality, can effectively eliminate condition difference between batch
Caused by unstable product quality the problems such as.
3) it is easy to amplification production：The fibre bundle crystallizer of the utility model is due to the special knot of internal fibre bundle
Structure, can achieve the purpose that amplification production by simply increasing internal tow quantity.
Brief description of the drawings
Fig. 1 is the single hollow porous fiber silk structure diagram of the utility model embodiment.
Fig. 2 is the fibre bundle mold structure schematic diagram of the utility model embodiment.
Fig. 3 is the structure diagram of the utility model embodiment.
Embodiment
Following embodiments will be further described the utility model with reference to attached drawing.
Referring to Fig. 1~3, the utility model embodiment, which is equipped with, divides solvent bottle 1, the 1st peristaltic pump 2, fibre bundle crystallizer, molten
Solve apothecary jar 4, the 2nd peristaltic pump 5 and vacuum filtering system 6；The fibre bundle crystallizer is equipped with outer tube 301 and inner tube 302, interior
Pipe 302 is located in outer tube 301；Solvent bottle 1 is divided to be connected with the entrance of the 1st peristaltic pump 2, the outlet of the 1st peristaltic pump 2 and fibre bundle
The inner tube inlet 31 of crystallizer connects, and the inner tube outlet 32 of fibre bundle crystallizer blocks, and dissolves 4 and the 2nd peristaltic pump 5 of apothecary jar
Entrance connection, the outlet of the 2nd peristaltic pump 5 is connected with the outer tube inlet 33 of fibre bundle crystallizer, fibre bundle crystallizer
Outer tube outlet 34 connects vacuum filtering system 6；The inner tube 302 of the fibre bundle crystallizer is made of hollow porous fiber tow.
The 1st pressure gauge 7 can be set between the outlet of 1st peristaltic pump 2 and the inner tube inlet 31 of fibre bundle crystallizer, the described 2nd is compacted
The 2nd pressure gauge 8 can be set between the outlet of dynamic pump 5 and the outer tube inlet 33 of fibre bundle crystallizer；Single hollow porous fiber silk
Porosity can be 80%.
The method that polymer overmold Nano medication is prepared using the utility model is as follows：
1) fibre bundle crystallizer is prepared：Single bundle hollow porous fiber tow is cut, is loaded into casing, is formed fine
Tow is tieed up, closes the inner tube outlet of fibre bundle crystallizer, to prevent fluid from being flowed out from the inner tube outlet of fibre bundle crystallizer；
Single bundle hollow porous fiber tow uses 30 PDVF hollow porous fiber silks, the length of single PDVF hollow porous fibers silk
Spend for 20cm, internal diameter is 600 μm, and the porosity of inner wall is 80%, and for 500nm, (Parameter adjustable is to adapt to Nano medication in aperture
Controlledly synthesis)；Described sleeve pipe uses PP casings, and the internal diameter of casing is 3cm.
2) preparation of Nano medication and polymer overmold：Load deionized water in solvent bottle is divided, will be divided by the 1st peristaltic pump
Solvent is sent into the inner tube inlet of fibre bundle crystallizer, and the inner tube outlet due to fibre bundle crystallizer blocked so that go from
Sub- water is extruded outward by the inner wall aperture of the fibre bundle in the inner tube of fibre bundle crystallizer；Outside fibre bundle crystallizer
Pipe is introduced into by the 2nd peristaltic pump the acetone soln of the dissolving medicine and polymer in dissolving apothecary jar, fibre bundle in the same time
The microring array that the deionized water that the inner tube of crystallizer is extruded outward is formed in a large amount of apertures of the outer tube of fibre bundle crystallizer
Uniformly mixed with drug solution at outer tube in environment, because deionized water can effectively reduce dissolving medicine and the acetone of polymer is molten
Solute solubility in liquid so that it is nano medicine crystal that medicine is first separated out from acetone soln, and post-consumer polymer is due to heterogeneous
It is nucleated and separates out and be coated on nano medicine crystal, realizes preparation and the polymer overmold of Nano medication；It is described to be wriggled by the 1st
The speed that deionized water is sent into the inner tube inlet of fibre bundle crystallizer by pump is 5ml/min；The fibre bundle crystallizer
The speed that outer tube is introduced into by the 2nd peristaltic pump the acetone soln of the dissolving medicine and polymer in dissolving apothecary jar in the same time can
For 5ml/min；The medicine uses griseofulvin (Griseofulvin), and the polymer uses acrylic resin
(Eudragit)；The structural parameters and reaction condition of fibre bundle crystallizer can accurately control the particle diameter of Nano medication particle
Size and coating thickness.
3) post-process：The nano medicine crystal of polymer overmold and the acetone soln of excessive dissolving medicine and polymer with
Deionized water is discharged by the outer tube outlet of fibre bundle crystallizer, is carried out collection of products into vacuum filtering system, is collected into
Nanometer filter cake be dried in vacuo after ultrasound filtration, up to polymer overmold Nano medication；The vacuum filtering system
Using nanofiltration membrane, the nanofiltration membrane is the PVDF filter paper GVWP04700 of Miliopore 220nm；The ultrasound filtration
Time is 20min.
Claims (3)
1. a kind of polymer overmold Nano medication preparation facilities, it is characterised in that equipped with dividing solvent bottle, the 1st peristaltic pump, filament
Beam crystallizer, dissolving apothecary jar, the 2nd peristaltic pump and vacuum filtering system；The fibre bundle crystallizer is equipped with outer tube and inner tube,
Inner tube is located in outer tube, divides solvent bottle and the entrance of the 1st peristaltic pump to be connected, outlet and the fibre bundle crystallizer of the 1st peristaltic pump
Inner tube inlet connection, fibre bundle crystallizer inner tube outlet closure, dissolving apothecary jar be connected with the entrance of the 2nd peristaltic pump,
The outlet of 2nd peristaltic pump is connected with the outer tube inlet of fibre bundle crystallizer, and the outer tube outlet of fibre bundle crystallizer connects vacuum
Filtration system；The inner tube of the fibre bundle crystallizer is made of hollow porous fiber tow.
2. a kind of polymer overmold Nano medication preparation facilities as claimed in claim 1, it is characterised in that the 1st peristaltic pump
The 1st pressure gauge is set between outlet and the inner tube inlet of fibre bundle crystallizer.
3. a kind of polymer overmold Nano medication preparation facilities as claimed in claim 1, it is characterised in that the 2nd peristaltic pump
The 2nd pressure gauge is set between outlet and the outer tube inlet of fibre bundle crystallizer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720158673.9U CN207286342U (en) | 2017-02-22 | 2017-02-22 | A kind of polymer overmold Nano medication preparation facilities |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720158673.9U CN207286342U (en) | 2017-02-22 | 2017-02-22 | A kind of polymer overmold Nano medication preparation facilities |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207286342U true CN207286342U (en) | 2018-05-01 |
Family
ID=62270185
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720158673.9U Expired - Fee Related CN207286342U (en) | 2017-02-22 | 2017-02-22 | A kind of polymer overmold Nano medication preparation facilities |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN207286342U (en) |
-
2017
- 2017-02-22 CN CN201720158673.9U patent/CN207286342U/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Yang et al. | Nanosized sustained-release drug depots fabricated using modified tri-axial electrospinning | |
| Gao et al. | Recent advances in microfluidic-aided chitosan-based multifunctional materials for biomedical applications | |
| CN103521150B (en) | Method for preparing cellulose microspheres and chitosan-coated cellulose composite microspheres | |
| Liu et al. | Microfluidic preparation of monodisperse ethyl cellulose hollow microcapsules with non-toxic solvent | |
| CN102417733B (en) | Preparation method of silk fibroin nanosphere | |
| CN107714674A (en) | A kind of preparation method of PLGA microballoons | |
| CN105780184B (en) | A kind of method that fiber is made in carboxymethyl cellulose progress electrostatic spinning | |
| CN107320450A (en) | A kind of nanometer formulation system method based on super critical CO 2 technology | |
| CN111012671A (en) | Physical preparation method of microcapsule | |
| CN103816843A (en) | Preparation method of uniformly-sized regenerated cellulose microspheres | |
| CN207286342U (en) | A kind of polymer overmold Nano medication preparation facilities | |
| Khademolqorani et al. | Application of electrosprayed nanoparticles as targeted drug delivery systems: a mini review | |
| CN106860428A (en) | Polymer overmold Nano medication preparation facilities and preparation method | |
| Carrick et al. | Native and functionalized micrometre-sized cellulose capsules prepared by microfluidic flow focusing | |
| CN108567763A (en) | A kind of Paeoniflorin nanocrystal and preparation method thereof | |
| CN105463702B (en) | A kind of compound spinning nanometer fiber membrane of the electrostatic of propolis-containing and its production method | |
| CN101147850B (en) | System for making nanometer level particle | |
| CN207286343U (en) | Acrylic resin coats the preparation facilities of Nano medication | |
| CN111588907A (en) | Preparation method of multifunctional heterostructure microfiber | |
| CN109265711B (en) | Preparation method of polymer particles | |
| CN111450078A (en) | Electrostatic spinning nanoparticle-entrapped pharmaceutical preparation and application thereof | |
| CN103251556B (en) | Aprepitant nanosuspension and preparation method thereof | |
| CN104402051A (en) | Preparation method for single-layer fluorescent nano-molybdenum disulfide | |
| CN109432056A (en) | A kind of composite nanometer particle of polymer overmold curcumin eutectic and its preparation and the application in pharmacy | |
| CN106890132A (en) | The method that Nano medication is coated with real wall fibre pipe beam crystallizer acrylic resin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180501 Termination date: 20210222 |
|
| CF01 | Termination of patent right due to non-payment of annual fee |