CN207286343U - Acrylic resin coats the preparation facilities of Nano medication - Google Patents
Acrylic resin coats the preparation facilities of Nano medication Download PDFInfo
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- CN207286343U CN207286343U CN201720159592.0U CN201720159592U CN207286343U CN 207286343 U CN207286343 U CN 207286343U CN 201720159592 U CN201720159592 U CN 201720159592U CN 207286343 U CN207286343 U CN 207286343U
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- crystallizer
- fibre pipe
- pipe beam
- inner tube
- acrylic resin
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Abstract
Acrylic resin coats the preparation facilities of Nano medication, is related to the preparation of Nano medication.Equipped with water bath device, dissolving apothecary jar, 2 peristaltic pumps, fibre pipe beam crystallizer, vacuum filtering system, refrigeration machine；Dissolving apothecary jar is located in water bath device, fibre pipe beam crystallizer is equipped with outer tube and inner tube, dissolving apothecary jar is connected with the 1st wriggling pump intake, 1st wriggling pump discharge is connected with the inner tube inlet of fibre pipe beam crystallizer, fibre pipe beam crystallizer inner tube outlet connects vacuum filtering system, the outlet of fibre pipe beam crystallizer outer tube is connected through refrigeration machine with the 2nd wriggling pump intake, 2nd wriggling pump discharge is connected with the outer tube inlet of fibre pipe beam crystallizer, and the inner tube of fibre pipe beam crystallizer is made of the hollow solid wall fiber tube bank of micron order.
Description
Technical field
The preparation of Nano medication is the utility model is related to, more particularly, to a kind of system of acrylic resin cladding Nano medication
Standby device.
Background technology
In recent years, with the continuous development of nanosecond science and technology, the nano-drug preparation that is formed based on nanometer technology research and development it is only
Property values are also gradually understood by researcher, however, directly using nano medicine crystal because of a variety of causes and it is difficult to direct
Applied to [1] in actual therapeutic.Gulped down as the hydrophobic type Nano medication of tradition is easily identified by the macrophage in vivo immuning system
Do not fail etc..Research finds, nano particle is coated using degradable polymer (such as PLGA, PEG etc.) made of
Polymer nanocomposite, which carries medicine particle, many advantages：Drug effectiveness is improved, controls release time, extends medicine biology and partly declines
Phase, is more easy to through cell membrane etc. [2~5].This to carry medicine particle for polymer nanocomposite and become existing medicament nano and cladding
Stage is by the popular problem of numerous studies.
The preparation of Nano medication at this stage and polymer overmold method are roughly divided into method from top to down and to lower and upper methods.Before
Person mainly by large-sized medicament nano and is coated using physical method.Such as Azad [6,7] uses wet method nanon ball-mill
By bulk pharmaceutical chemicals nanosizing, polymer nano granules are then prepared at high temperature using spray drying or fluid bed.The latter then uses
Chemical method, from molecular level by accurately controlling solution mixing and precipitation process, prepares nano particle.Such as Ali [8]
Using nanoprecipitation method, using dividing solvent to be mixed with drug particles in cross line, it is suspended to be prepared for metastable nanometer
Liquid；Paisana etc. [9] uses supercritical CO at high temperature under high pressure using super-critical rapid expansion method (RESS)2Prepare nanometer medicine
Composition granule；Sahana etc. [10] prepares the Nano medication of PLGA claddings using emulsification-diffusion-evaporation.Li etc. [11] passes through O/W
Nanometer emulsified method prepares the Nano medication suspension of polymer overmold.But these method for coating all come with some shortcomings.It is based on
The nanometer emulsified method of O/W is easily due to peculiar property (high-ratio surface energy, the strong Van der Waals of nano particle in preparation process
Power) and produce soft-agglomerated phenomenon in the solution, the polymer overmold of production live multiple nano particles and caused by hard aggregation can not
Separated；Supercritical CO2Technology is then because the low solubility of polymer or drug particles make it that the large-scale production of medicine is limited
System；Vapour deposition cladding process needs the high energy consumption condition such as high temperature；Spray drying technology needs hot conditions, and to the nanometer of preparation
Particle diameter is restricted, it is difficult to prepare the particle less than 10nm；Most of preparation method is all batch production at this stage
(batch process), causes production efficiency low, uneven per a batch of quality, it is difficult to be had in practical application
Effect regulation and control.Therefore how it is successional produce that performance is controllable, reaction condition is gentle and the polymer overmold of stable quality
Nano medication particle become the emphasis studied at present and difficult point.
Bibliography：
[1]Harrison R,Li L,Zi G,et al.Controlling mesoporous silica-coating
of layered double hydroxide nanoparticles for drug control release[J]
.Microporous&Mesoporous Materials,2016,238:97-104.
[2]GD,Grumezescu AM,Bejenaru C,et al.Polymeric protective
agents for nanoparticles in drug delivery and targeting.[J].International
Journal of Pharmaceutics,2016,510(2):419-429.
[3]Kumari A,Yadav S K,Yadav S C.Biodegradable polymeric nanoparticles
based drug delivery systems.[J].Colloids&Surfaces B Biointerfaces,2009,75(1):
1-18.
[4]Azeem B,Kushaari K Z,Man Z.Effect of Coating Thickness on Release
Characteristics of Controlled Release Urea Produced in Fluidized Bed Using
Waterborne Starch Biopolymer as Coating Material☆[J].Procedia Engineering,
2016,148:282-289.
[5]Bala,I.,Hariharan,S.,Kumar,R.,2004.PLGA nanoparticles in drug
delivery:the state of the art.Crit.Rev.Ther.Drug Carrier Syst.21,387–422.
[6]Azad M,Arteaga C,Abdelmalek B,et al.Spray drying of drug-swellable
dispersant suspensions for preparation of fast-dissolving,high drug-loaded,
surfactant-free nanocomposites.[J].Drug Development and Industrial Pharmacy,
2015,41(10):1-15.
[7]Azad M,Moreno J,Bilgili E,et al.Fast dissolution of poorly water
soluble drugs from fluidized bed coated nanocomposites:Impact of carrier
size.[J].International Journal of Pharmaceutics,2016,513(1):319-331.
[8]Ali H S,York P,Blagden N.Preparation of hydrocortisone
nanosuspension through a bottom-up nanoprecipitation technique using
microfluidic reactors.[J].International Journal of Pharmaceutics,2009,375(1-
2):107-113.
[9]Paisana M C,Müllers K C,Wahl M A,et al.Production and
Stabilization of Olanzapine Nanoparticles by Rapid Expansion of Supercritical
Solutions(RESS)[J].Journal of Supercritical Fluids the,2015,109(1):124-133.
[10]Sahana D K,Mittal G,Bhardwaj V,et al.PLGA Nanoparticles for Oral
Delivery of Hydrophobic Drugs:Influence of Organic Solvent on Nanoparticle
Formation and Release Behavior In Vitro,and In Vivo,Using Estradiol as a
Model Drug[J].Journal of Pharmaceutical Sciences,2008,97(4):1530-1542.
[11]Li J,Hwang I C,Chen X,et al.Effects of chitosan coating on
curcumin loaded nano-emulsion:Study on stability and invitro digestibility
[J].Food Hydrocolloids,2016,60:138-147.
The content of the invention
The purpose of this utility model is to provide a kind of preparation facilities of acrylic resin cladding Nano medication.
The utility model is equipped with water bath device, dissolving apothecary jar, the 1st peristaltic pump, fibre pipe beam crystallizer, vacuum filter system
System, refrigeration machine and the 2nd peristaltic pump；The dissolving apothecary jar is located in water bath device, and the fibre pipe beam crystallizer is equipped with outer tube
And inner tube, inner tube are located in outer tube, dissolving apothecary jar is connected with the entrance of the 1st peristaltic pump, the outlet of the 1st peristaltic pump and fibre pipe
The inner tube inlet connection of beam crystallizer, the inner tube outlet of fibre pipe beam crystallizer connect vacuum filtering system, fibre pipe beam crystallizer
Outer tube outlet be connected through refrigeration machine with the entrance of the 2nd peristaltic pump, the outlet of the 2nd peristaltic pump and the outer tube of fibre pipe beam crystallizer
Entrance connects, and the fibre pipe beam crystallizer is the hollow solid wall fibre pipe beam crystallizer of micron order, the fibre pipe beam crystallizer
Inner tube be made of the tube bank of micron order hollow solid wall fiber.
The 1st thermometer, the fibre can be set between the outlet of 1st peristaltic pump and the inner tube inlet of fibre pipe beam crystallizer
Can set the 2nd thermometer between the inner tube outlet and vacuum filtering system of vascular bundle crystallizer, the fibre pipe beam crystallizer it is outer
Pipe is exported can set the 3rd thermometer between refrigeration machine, can between the outer tube inlet of the 2nd peristaltic pump and fibre pipe beam crystallizer
If the 4th thermometer；
Using the utility model to prepare the specific steps of acrylic resin cladding Nano medication can be for：
1) fibre pipe beam crystallizer is prepared：The hollow solid wall fiber tube bank of single bundle micron order is cut, is loaded into casing,
Form fibre pipe beam crystallizer；The hollow solid wall fiber tube bank of single bundle micron order can use the hollow solid wall fibre pipes of 30 PDVF
Beam, the length of the single hollow solid wall fiber tube banks of PDVF can be 20cm, and internal diameter can be 400 μm, and outside diameter can be 600 μm.Inside pipe wall
For imperforate wall (Parameter adjustable to adapt to the controlledly synthesis of Nano medication)；Described sleeve pipe can use PP casings, and the internal diameter of casing can
For 3cm；Outer tube of the described sleeve pipe as fibre pipe beam crystallizer.
2) preparation of Nano medication is coated with acrylic resin：Load dissolving medicine and acrylic acid tree in apothecary jar is dissolved
The acetone soln of fat, fibre pipe beam crystallizer is sent the acetone soln for dissolving medicine and acrylic resin into by the 1st peristaltic pump
Inner tube inlet, the 2nd peristaltic pump will by the aqueous solution of cryocooled by fibre pipe beam crystallizer outer tube inlet introduce and outside
Circulate in pipe, since the ultra-thin tube wall that fiber is restrained in inner tube possesses the great capacity of heat transmission and temperature control capability, can make
Make the microenvironment of accurate equal control solution degree of supersaturation so that the medicine in fiber tube bank causes its molten because of quick cooling
Xie Du is reduced rapidly, and it is nano medicine crystal to cause first nucleation and growth in its supersaturated solution from acetone, then propylene
Acid resin is coated on the nano medicine crystal of preferential crystallization due to heterogeneous precipitation；The dissolving medicine can be griseofulvin
(Griseofulvin), it is described that the acetone soln for dissolving medicine and acrylic resin is sent into fibre pipe binding by the 1st peristaltic pump
The speed of the inner tube inlet of brilliant device can be 5ml/min；2nd peristaltic pump will be restrained by the aqueous solution of cryocooled by fiber
The outer tube inlet of crystallizer introduces and can be 5ml/min in the speed of outer tube circulation；The structural parameters of fibre pipe beam crystallizer and
Reaction condition can accurately control the particle size and coating thickness of Nano medication particle.
3) post-process：The nano medicine crystal of acrylic resin cladding is with excessive organic solution by fibre pipe beam crystallizer
Inner tube outlet discharge, into vacuum filtering system carry out collection of products, the nanometer filter cake being collected into by ultrasound filtration it is laggard
Row vacuum drying, up to the Nano medication of acrylic resin cladding.The vacuum filtering system can use nanofiltration membrane, described to receive
Rice filter membrane can be the PVDF filter paper GVWP04700 of Miliopore 220nm；The time of the ultrasound filtration can be 20min.
Compared with the existing method for preparing acrylic resin cladding Nano medication, the utility model has following prominent excellent
Point：
1) particle diameter and polymer overmold layer thickness of Nano medication are accurately controlled caused by flash heat transfer process：Micron order is real
The ultra micro tube wall (be less than 100 μm) of wall fiber tube bank can high efficiency regulatory outer tube circulating cooling liquid cooling transmittance process, rapid drop
Low inner tube solution temperature, makes crystallization precipitation process accurately be adjusted, so as to reach control nanocrystal particle diameter and coating thickness
The purpose of (10nm).
2) preparation condition is gentle：Compared to the high-temperature and high-pressure conditions that majority prepares nano-particle needs, the utility model only needs
The preparation condition of gentle (normal pressure and temperature is less than 50 DEG C), can effectively save energy consumption and cost.
3) the fibre pipe beam crystallizer that the utility model uses is a kind of continuous type crystallizer, inside fibre pipe beam crystallizer
React for tandem reaction sequence, can be in time by regulating and controlling response parameter integration production size tunable for being produced compared to batch
Acrylic resin nano medicine crystal, be conducive to increase yield with control product quality, condition is poor between can effectively eliminating batch
Caused by different the problems such as unstable product quality.
4) it is easy to amplification production：The fibre pipe beam crystallizer of the utility model is due to the special knot of internal fiber tube bank
Structure, can achieve the purpose that amplification production by simply increasing internal tube bank quantity.
Brief description of the drawings
Fig. 1 is the hollow solid wall fibre pipe structure diagram of single micron order of the utility model embodiment.
Fig. 2 is the fibre pipe beam crystallizer structure diagram of the utility model embodiment.
Fig. 3 is the structure diagram of the utility model embodiment.
Embodiment
Following embodiments will be further described the utility model with reference to attached drawing.
Referring to Fig. 1~3, the utility model embodiment is equipped with water bath device 1, dissolving apothecary jar 2, the 1st peristaltic pump 3, fiber
Restrain crystallizer, vacuum filtering system 5,6 and the 2nd peristaltic pump 7 of refrigeration machine；The dissolving apothecary jar 2 is located in water bath device 1,
The fibre pipe beam crystallizer is equipped with outer tube 401 and inner tube 402, and inner tube 402 is located in outer tube 401, dissolves apothecary jar 2 and the 1st
The entrance connection of peristaltic pump 3, the outlet of the 1st peristaltic pump 3 are connected with the inner tube inlet 41 of fibre pipe beam crystallizer, fibre pipe binding
The inner tube outlet 42 of brilliant device connects vacuum filtering system 5, and the outer tube outlet 44 of fibre pipe beam crystallizer is wriggled through refrigeration machine 6 and the 2nd
The entrance connection of pump 7, the outlet of the 2nd peristaltic pump 7 are connected with the outer tube inlet 43 of fibre pipe beam crystallizer, the fibre pipe binding
The inner tube 402 of brilliant device is made of the tube bank of hollow solid wall fiber.The outlet of 1st peristaltic pump 3 is interior with fibre pipe beam crystallizer
The 1st thermometer 8 is set between tube inlet 41, is set between the inner tube outlet 42 and vacuum filtering system 5 of the fibre pipe beam crystallizer
2nd thermometer 9, sets the 3rd thermometer 10, the described 2nd is compacted between the outer tube outlet 44 of the fibre pipe beam crystallizer and refrigeration machine 6
The 4th thermometer 11 is set between dynamic pump 7 and the outer tube inlet 43 of fibre pipe beam crystallizer；
The specific method that acrylic resin cladding Nano medication is prepared using the utility model is as follows：
1) fibre pipe beam crystallizer is prepared：The hollow solid wall fiber tube bank of single bundle micron order is cut and loaded in casing, structure
Into fibre pipe beam crystallizer；The hollow solid wall solid wall fiber tube bank of single bundle micron order uses the hollow solid wall fibre pipes of 30 PDVF
Beam, the length of single PDVF doughnuts tube bank is 20cm, and internal diameter is 400 μm, and outside diameter is 600 μm, and inner wall is imperforate wall (parameter
It is adjustable to adapt to the controlledly synthesis of Nano medication)；Described sleeve pipe uses PP casings, and the internal diameter of casing is 3cm；Described sleeve pipe conduct
The outer tube of fibre pipe beam crystallizer.
2) preparation of Nano medication is coated with acrylic resin：Load dissolving medicine and acrylic acid tree in apothecary jar is dissolved
The acetone soln of fat, fibre pipe beam crystallizer is sent the acetone soln for dissolving medicine and acrylic resin into by the 1st peristaltic pump
Inner tube inlet, the 2nd peristaltic pump will by the aqueous solution of cryocooled by fibre pipe beam crystallizer outer tube inlet introduce and outside
Pipe circulates, since the ultra-thin tube wall that the fiber of inner tube is restrained possesses the great capacity of heat transmission and temperature control capability so that inner tube
In medicine cause its solubility to reduce rapidly because of fast cooling, cause in its supersaturated solution from acetone first to separate out and receive
Rice medicine crystal, then acrylic resin due to it is heterogeneous precipitation and be coated on the nano medicine crystal of preferential crystallization；It is described molten
Solution medicine is griseofulvin (Griseofulvin), described by the 1st peristaltic pump that the acetone for dissolving medicine and acrylic resin is molten
The speed that liquid is sent into the inner tube inlet of fibre pipe beam crystallizer is 5ml/min；2nd peristaltic pump is by by the refrigeration in refrigeration machine
The aqueous solution of agent cooling is introduced by the outer tube inlet of fibre pipe beam crystallizer and is 5ml/min in the speed of outer tube circulation；Fiber
The particle size and cladding thickness of Nano medication particle can accurately be controlled by restraining the structural parameters of crystallizer and reaction condition
Degree.
3) post-process：The nano medicine crystal of acrylic resin cladding is with excessive organic solution by fibre pipe beam crystallizer
Inner tube outlet discharge, into vacuum filtering system carry out collection of products, the nanometer filter cake being collected into by ultrasound filtration it is laggard
Row vacuum drying, up to the Nano medication of acrylic resin cladding.The vacuum filtering system uses nanofiltration membrane, the nanometer
Filter membrane is the PVDF filter paper GVWP04700 of Miliopore 220nm；The time of the ultrasound filtration is 20min.
Claims (5)
1. acrylic resin coats the preparation facilities of Nano medication, it is characterised in that equipped with water bath device, dissolving apothecary jar, the 1st
Peristaltic pump, fibre pipe beam crystallizer, vacuum filtering system, refrigeration machine and the 2nd peristaltic pump；The dissolving apothecary jar is located at water-bath dress
In putting, the fibre pipe beam crystallizer is equipped with outer tube and inner tube, and inner tube is located in outer tube, dissolving apothecary jar and the 1st peristaltic pump
Entrance connects, and the outlet of the 1st peristaltic pump is connected with the inner tube inlet of fibre pipe beam crystallizer, and the inner tube of fibre pipe beam crystallizer goes out
Mouth connects vacuum filtering system, and the outer tube outlet of fibre pipe beam crystallizer is connected through refrigeration machine with the entrance of the 2nd peristaltic pump, and the 2nd is compacted
The outlet of dynamic pump is connected with the outer tube inlet of fibre pipe beam crystallizer, and the fibre pipe beam crystallizer is fine for the hollow solid wall of micron order
Vascular bundle crystallizer, the inner tube of the fibre pipe beam crystallizer are made of the hollow solid wall fiber tube bank of micron order.
2. the preparation facilities of acrylic resin cladding Nano medication as claimed in claim 1, it is characterised in that the 1st peristaltic pump
Outlet and fibre pipe beam crystallizer inner tube inlet between set the 1st thermometer.
3. the preparation facilities of acrylic resin cladding Nano medication as claimed in claim 1, it is characterised in that the fiber tube bank
The 2nd thermometer is set between the inner tube outlet and vacuum filtering system of crystallizer.
4. the preparation facilities of acrylic resin cladding Nano medication as claimed in claim 1, it is characterised in that the fiber tube bank
The 3rd thermometer is set between the outer tube outlet of crystallizer and refrigeration machine.
5. the preparation facilities of acrylic resin cladding Nano medication as claimed in claim 1, it is characterised in that the 2nd peristaltic pump
The 4th thermometer is set between the outer tube inlet of fibre pipe beam crystallizer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720159592.0U CN207286343U (en) | 2017-02-22 | 2017-02-22 | Acrylic resin coats the preparation facilities of Nano medication |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720159592.0U CN207286343U (en) | 2017-02-22 | 2017-02-22 | Acrylic resin coats the preparation facilities of Nano medication |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207286343U true CN207286343U (en) | 2018-05-01 |
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ID=62270173
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720159592.0U Expired - Fee Related CN207286343U (en) | 2017-02-22 | 2017-02-22 | Acrylic resin coats the preparation facilities of Nano medication |
Country Status (1)
| Country | Link |
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| CN (1) | CN207286343U (en) |
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2017
- 2017-02-22 CN CN201720159592.0U patent/CN207286343U/en not_active Expired - Fee Related
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| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20180501 Termination date: 20210222 |
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| CF01 | Termination of patent right due to non-payment of annual fee |