CN207232003U - Biological culture microanalysis cuvette - Google Patents
Biological culture microanalysis cuvette Download PDFInfo
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- CN207232003U CN207232003U CN201720938510.2U CN201720938510U CN207232003U CN 207232003 U CN207232003 U CN 207232003U CN 201720938510 U CN201720938510 U CN 201720938510U CN 207232003 U CN207232003 U CN 207232003U
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Abstract
The utility model discloses a kind of biological culture microanalysis cuvette, its structure is made of the sample-adding portion connected up and down and test section, the reaction solution that test section is flowed into by controlling is equipped with sample-adding portion, detected material is placed in test section, the connectivity part of the sample-adding portion and test section is equipped with the inclined plane at 48 55 degree of angle, and reflectance coating polarizer is placed in the inclined plane.
Description
Technical field
The present invention relates to technical field of biological, more particularly to a kind of biological culture microanalysis cuvette.
Background technology
Analysis cuvette（Absorption cell, sample cell）Liquid, sample liquid are referred to for filling, it is right on optic analytical instrument to be matched with
Substance quantitative analysis, is widely used in chemical industry, medical treatment, medicine, food, environmental protection.In recent years, in the field such as medical treatment, food, medicine,
DNA, enzyme, protein, virus, cytology, living beings, clinical analysis, environmental analysis, genetic analysis, protein analysis, cell
Analysis, drug resistance screening, from the large-scale cuvette of tradition gradually trend in small-sized cuvette（That is micro updating）Detection level, separates, is anti-
Answer, mix, being measured to detection as a result, also being paid close attention to using micro flow chip or micro fluid structure by people.
Existing China Patent No.：Stated clearly in 201210363071.9, it traditional cylinder, cuboid cuvette into
Row improvement, realizes semimicro, that is, employs top wide opening structure, lower part fillet structure, hold level with both hands in the fillet structure of lower part
The sliding lower end for being transitioned into part-structure（As shown in Figure 1）, but the cuvette in above-mentioned patent can not apply to the inspection of micro updating
Survey and quantitative, in addition it is only applicable to optical transmission method, and needs are detected with the fluorescent value of microorganism with second of exciting light, should
Cuvette has no idea to be detected.
And in China Patent No.：3M biological sterilization indicators in 201180052867.6, select top wide opening, lower part narrow
Bar structure, top employ the mode on inclined-plane with lower interface, it is simply mentioned and easily flows into lower part easy to upper liquid, not to oblique
Face light reflection surface angle, different photodiffusion materials, diffusion angle are different, and luminous intensity can produce second of exciting light after refraction
The data such as raw different influence are analyzed.
Second of exciting light outflow optical path improvement, can greatly improve the sensitivity of detection.The material of optical diffusion film is different,
Reflected light, which is passed in detectable substance, excites second light quantity different, influences testing result, and the bubble in detection pipe is accurate to detecting
Property can also have an impact, select concavo-convex interior wall construction to eliminate the influence that bubble produces testing result.
Top is used in Japanese Patent Laid 2012-503994 as nutrient solution, lower part is that detection object is biomass.On
When portion's nutrient solution is cultivated with lower part detection liquid, top employs fashion of extrusion up and down with lower part and completes, but the invention lacks
Quantitative analysis is carried out with optical analyzer.In Japanese Unexamined Patent Application Publication 2009-501592 containers for culturing organisms devices, effective nutrient solution and bacterium piece
Separated, using it is upper easily, but the problem of there is also quantitative analysis can not be carried out with optical analyzer.Japanese Unexamined Patent Application Publication
Fluor tester in 2014-145633, using two to spectroscopic approach, can effectively detect flat fluorescent, but fluor tester
In use two to spectroscope, two to spectroscopical costly.
The content of the invention
In order to overcome drawbacks described above, it can be tested the present invention provides one kind and quickly obtain testing result, be greatly saved
Cost, while overcome and artificially dosing the biological culture microanalysis cuvette of loading errors caused by reagent.
To reach above-mentioned purpose, the present invention provides a kind of biological culture microanalysis cuvette, its structure by connecting up and down
Sample-adding portion and test section composition.The reaction solution that test section is flowed into by controlling is equipped with sample-adding portion, is placed in test section tested
The connectivity part of survey thing, the sample-adding portion and test section is equipped with the inclined plane at a 48-55 degree angle, and one piece is placed in the inclined plane
Light can be made to change nyctitropic device.
As a further improvement on the present invention, the test section internal capacity volume is below 100 μ L, less than sample-adding portion
Internal capacity volume.
As a further improvement on the present invention, rough structure is used on the madial wall of the test section, if its by
The dry groove being intervally arranged is formed, and prevents the bubble of liquid from being impacted to detection accuracy.
As a further improvement on the present invention：The connectivity part of sample-adding portion and test section is equipped with a 48-55 degree inclined-plane, inclined-plane
Light disperser is configured with, this device material selection can make light change nyctitropic efficient material, such as：Select plastic foil,
Plastic foil is applicable in luminous energy and effectively spreads coating, carries out coating treatment；Select nano barium sulfate, titanium dioxide, nano oxidized aluminium paint.
It cannot select and absorb ultraviolet material progress coating, such as cerium oxide material is handled.Coating treatment is carried out on light diffusion thin slice,
Aperture is optimal between 1-2mm, and micropore is optimal as far as possible with 10-20 every square centimeter.Micropore is more to influence light
Change nyctitropic effect, micropore, which has lacked, can influence to be loaded flowing down for liquid.Plastic film layer thickness is preferred with 10 microns（10 microns with
The lower diffusion effect that can influence light）, change the light after incident light, the efficiency of light can be substantially increased, it is irradiated to checking matter
Matter position.The second exciting light of checking matter can be so activated, such as fluorescence, improves brightness（Such as fluorescence）, the light of so slow reflected light
Exposure area increases, and greatly improves second of activation luminous effect, the first incident light of reduction is too strong, shines directly into detectable substance
On.
It is local as a further improvement on the present invention, footpath is gone out to second of activation light and is improved.Second of exciting light one
As it is very weak, detection sensitivity is affected, improve detection sensitivity, it is necessary to outflow optical path inquire into.As the present invention's
Further improve, the angle of incident light and reflected light.The size of diffusion barrier angle determines that Light-Echo detection method whether can
Set up.Different angles detects different as a result, only selection is in 48-55 degree reflectings surface, just suitable for Light-Echo detection
Method.
As a further improvement on the present invention, the sample-adding portion is squeezed for the direct sample addition type of upper end opening or reaction liquid closed
Broken method sample addition type.
As a further improvement on the present invention, the sample-adding portion is that the structure that reaction liquid closed racks method sample addition type is：
The upper end is arranged a sealing ring slided up and down along sample-adding portion upper end side wall, and the reaction solution of closing is equipped with the sealing ring, is added
The device that racks of a fixation is equipped with sample portion, is easily to rack position below sealing ring, when the sealing ring is snapped down to lowest positions,
Rack device rack below sealing ring easily rack position, reaction solution is entered sample-adding portion, finally flow to test section.
As a further improvement on the present invention, the detected material can be microbe carrier, enzyme, enzyme reaction thing, it is carried
Body is contained mode and selects water imbibition filter paper, energy carrier liquid container, liquid dry freeze to be consolidated into detection reagent or by the way of photocuring
Due to test section, carrier liquid volume is between 10 μ L-100 μ L.
As a further improvement on the present invention, the sample-adding portion and test section are using transparency, degree uniform in material, translucency
And reflective is good, mould is processed easily molded polypropylene, polyethylene, polymethyl methacrylate, polycarbonate and is made.
As a further improvement on the present invention, the light of the inclined plane is radiated on a polarizer, enters reflected light
Second of exciting light is sent on detected material, on detected material.
As a further improvement on the present invention, the reflectance coating polarizer for two to mirror, sheet glass or plastic sheet.
As a further improvement on the present invention, which is PET reflection film polarizer.
As a further improvement on the present invention, which is equipped with horn mouth, second of exciting light is more accurately collected
In be transmitted on receiver, increase fluorescence signal value.
The beneficial effects of the invention are as follows：
By in analysis cuvette, 1. sample room, sensing chamber are improved the present invention by traditional analysis with cuvette method,
Detection amount of samples is reduced, and detection reagent is concentrated, reaction solution need not be added again by realizing in analysis；Design micro updating
Sensing chamber, the effect of detection and analysis can be reached in the short time；It is few especially suitable for own analysis sample size.
2. selecting reflection method testing principle, the angle of incident light and reflected light is improved, especially demonstration is incident
The angle problem of light and reflected light.How substantial amounts of entrance reflected light could be obtained to improve accuracy of detection, while to reflection
The effect that the material of light produces is into line justification.
3. in the case of second of optical excitation signal of pettiness, " horn mouth " concentration structure can be used, spirit can be improved
Sensitivity, realizes the function that pettiness signal can detect.
4. second of exciting light outflow optical path improvement, greatly improves the sensitivity of detection.The material of optical diffusion film is different, instead
Penetrate light and be passed in detectable substance and excite second light quantity different, influence testing result, the bubble in detection pipe is to accuracy of detection
Also it can have an impact, select concavo-convex interior wall construction to eliminate the influence that bubble produces testing result.
Above optical texture solves the problems, such as insufficient with reflected light in Light-Echo detection.The invention of this technology, can be with
Apply to activity in vivo material, such as：The detection for the micro substances such as enzyme metabolism, protein, nucleic acid, agriculture be residual.Greatly reduce at the same time
Polariscope manufactures costly and complicated structure in incident light direct scan, its invention has extensive practical value.
Brief description of the drawings
Fig. 1 is China Patent No.：201210363071.9 middle cuvette schematic diagram；
Fig. 2 is schematic structural view of the invention；
Fig. 3 is test section inner sidewall structure schematic diagram of the present invention；
Fig. 4 is that sample-adding portion of the present invention is to react the structure diagram that liquid closed racks method sample addition type；
Fig. 5 is the structure diagram of flat inclined light disperser of the present invention；
Fig. 6 is the fluorescence data figure of test section reflectance coating polarizer of the present invention；
Fig. 7 is the difference that signal is detected to reflection method of different light diffusion coatings；
Fig. 8 is the schematic diagram of second of exciting light optical path of the invention；
Fig. 9 is the bell-mouthed fluorescence data figure of test section of the present invention；
Figure 10 is that the test section of the present invention improves the schematic diagram before and after horn mouth；
Figure 11 is concentration and the relation of fluorescent value when the angle of inclined plane is 70 degree, 30 degree, 40 degree, 48 degree and 55 degree
Figure；
Figure 12 is the schematic diagram of the cuvette of the inclined plane of different angle；
Figure 13 is the testing result of the embodiment of the present invention 1；
Figure 14 uses schematic diagram for the embodiment of the present invention 2；
Figure 15 is concentration known CRP titer datagrams；
Figure 16 is that standard curve made of concentration known CRP titers is selected in embodiment 2.
Indicated in figure：1- sample-addings portion；2- test sections；3- reaction solutions；4- detected materials；5- reflectance coating polarizers；6- is closed
Circle；7- racks device；8- receivers；9- horn mouths.
Embodiment
In order to deepen the understanding of the present invention, below in conjunction with embodiment and attached drawing, the invention will be further described, should
Embodiment is only used for explaining the present invention, is not intended to limit the scope of the present invention..
Fig. 2 is a kind of structure diagram of biological culture microanalysis cuvette of the present invention, it is added by what connection up and down was set
Sample portion 1 and test section 2 form, and the reaction solution 3 that test section is flowed into by controlling is equipped with the sample-adding portion 1, is placed in test section 2
Detected material 4, the connectivity part of the sample-adding portion 1 and test section 2 are equipped with the inclined plane at a 48-55 degree angle, in the inclined plane
Reflectance coating polarizer 5 is placed, and 2 internal capacity volume of the test section is below 100 μ L, less than the internal capacity in sample-adding portion 1
Volume.
Referring to Fig. 3, it is test section inner sidewall structure schematic diagram of the present invention, as shown in the figure, the madial wall of the test section 2
Upper to use rough structure, it is made of some grooves being intervally arranged, and is allowed small bubble to disappear on the trench walls, so may be used
Avoid detecting the error that steam bubble produces when passing through,.
As shown in figure 4, the sample-adding portion 1 is to react liquid closed and rack the structure of method sample addition type to be：The upper end is arranged one
The sealing ring 6 slided up and down along sample-adding portion upper end side wall, the sealing ring 6 is interior to be equipped with the reaction solution 3 closed, and is set in sample-adding portion 1
Have a fixation racks device 7, and the lower section of sealing ring 6 when the sealing ring 6 is snapped down to lowest positions, racks easily to rack position
Device 7 racks and easily racks position below sealing ring, reaction solution 3 is entered sample-adding portion 1, finally flow to test section 2, waits to take and racks
Sample adding liquid, after reaction solution 3 is fully reacted with detected material 4, then is detected, and selects the method to make as biological culture dish
Seal carrier is necessary for, it is desirable to sample-adding portion upper end, and this method is mainly used for microorganism count, quantitative and microorganism deposits
Analysis living, it is desirable to which inlet port is very little window body, prevents the influence of other microorganisms.
The detected material 4 can be microbe carrier, enzyme, enzyme reaction thing, its carrier contains mode and selects water imbibition to filter
Paper, liquid container can be carried, liquid dry freeze is fixed on test section 2 into detection reagent or by the way of photocuring, carrier liquid body
Product is between 10 μ L-100 μ L, most preferably 50 μ L.
The sample-adding portion 1 and test section 2 are using transparency, degree uniform in material, translucency and reflective is good, mould processing is easy
Molding polypropylene, polyethylene, polymethyl methacrylate, polycarbonate are made, and transparent material cuvette is used in biochemical analysis
It is upper for industry it is conventional, it is proposed that first with high temperature resistant, the material of not flexible type, the slightly material of modification can be to microcolorimetric ware detection light
Road system produces very big error.
In this present embodiment, it is configured with photodiffusion material in the inclined plane, this material is that can to change light nyctitropic
Efficient material, such as：Plastic foil is selected, plastic foil is applicable in luminous energy and effectively spreads coating, carries out coating treatment；Select nano-sulfur
Sour barium, titanium dioxide, nano oxidized aluminium paint.It cannot select and absorb ultraviolet material progress coating, such as cerium oxide material is handled.
As shown in figure 5, to carry out coating treatment on light diffusion thin slice, such as nano surface coating 10, loophole 20, and printing opacity which is provided with
The aperture in hole 20 is optimal between 1-2mm, and loophole 20 is optimal, loophole 20 as far as possible with 10-20 every square centimeter
More nyctitropic effects that change that can influence light, loophole 20, which has lacked, can influence to be loaded flowing down for liquid.
The layer thickness of plastic foil 30 is preferred with 10 microns（Less than the 10 microns diffusion effects that can influence light）, change incident light
Light afterwards, can substantially increase the efficiency of light, it is irradiated to analyte 4, can so activate the second exciting light of checking matter,
Such as fluorescence, brightness is improved.The light exposure area increase of so slow reflected light, greatly improves second of activation luminous effect, reduces
First incident light is too strong, shines directly on detected material 4.
Referring to Fig. 6, be the difference of different material reflection method detection signals, with reference to refering to following table and Fig. 7, for not
The difference to reflection method detection signal of same light diffusion coating.
| 4 methyl umbelliferones | Barium sulfate | Titanium oxide | Nylon membrane | Aluminium oxide |
| 0.0004 | 2130 | 1980 | 927 | 720 |
| 0.00004 | 1500 | 950 | 128 | 85 |
As shown in figure 8, the light of the inclined plane is radiated on polarizer 5, reflected light is set to enter on detected material 4, quilt
Second of exciting light is sent in detectable substance 4, since second of exciting light is generally very weak, detection sensitivity is vulnerable to influence, therefore,
The test section 2 is equipped with horn mouth 9, please refers to Fig. 9, which concentrates and is transmitted on receiver 8, improves the
Secondary activating luminous effect, the first incident light of reduction is too strong, shines directly into detectable substance, to the back of the body of second of excitation when detecting
The high situation of scenery, by taking the second exciting light is fluorescence as an example, it can be seen from the figure that horn mouth 9 improves fluorescent brightness, increase
Fluorescence signal value.
During fluorescence analysis for microorganism, using reflection method principle, i.e., by the use of the inclined plane as the reaction surface of light,
Inclined-plane light is radiated in astigmatism plate, allows reflected light to be radiated on detected material 4, second of light is excited on detected material 4, should
Second of light outflow is equipped with horn mouth 9 to test section 2, the test section 2, which, which concentrates, is transmitted on receiver 8.This
Invention goes out second of activation light the improvement in footpath, and as shown in Figure 10, since second of exciting light is generally very weak, detection sensitivity is easy
It is affected, after being improved to outflow optical path, improves detection sensitivity.
It is significant to note that the angle of incident light and reflected light, the size of inclined plane angle determines that light reflection is examined
Whether survey method can be set up, and please refer to Fig.1 1, and the angle for being inclined plane is dense when being 70 degree, 30 degree, 40 degree, 48 degree and 55 degree
The graph of a relation of degree and fluorescent value, as shown in figure 11, fluorescent value is higher when inclined plane is 48 degree and 55 degree, therefore present invention determine that inclines
The angular range on inclined-plane is 48-55 degree, in this angular range, suitable for Light-Echo detection method.In addition, different angle detection
Go out different result concentration values it is identical when, please refer to Fig.1 2, be different angle inclined plane cuvette schematic diagram, such as scheme
It is shown, it is respectively the schematic diagram of the cuvette of 45 degree, 50 degree and 65 degree of inclined plane.
Embodiment 1
350nm, 450nm wavelength incident light are selected, through 30 ° of 45 ° of 53 ° of 60 ° of 70 ° of different angles, to detect various concentrations
The fragrant element of beans, carries out Experiments of Optics, experimental result shows that bevel angle linear relationship between 48-55 degree is good as shown in fig. 13 that
It is good, quantitative analysis can be carried out to the experiment of microlitre sample.
Embodiment 2
4 are please referred to Fig.1, applying to CRP in serum for the present invention measures：
4% polyvinyl alcohol 6000 of reagent R1 50mM pH7.5 HEPES buffer solutions
1% Nacl
1mm EDTA
Reagent R2 50mM HEPES pH of buffer 7.5
1% Nacl
Anti-human CRP rabbit antibodies serum
15 microlitres of human serum is taken, 250 microlitres of R1 reagents is added, treats to add 50 microlitres of R2 reagents after five minutes, treat 5 minutes
Afterwards, 340nm wavelength measure absorbance.
Standard curve is made in the concentration known CRP titers selected in Figure 15, as shown in figure 16.
Claims (10)
- A kind of 1. biological culture microanalysis cuvette, it is characterised in that：By the sample-adding portion (1) of connection setting and test section up and down (2) form, the reaction solution (3) that test section (2) is flowed into by controlling is equipped with the sample-adding portion (1), quilt is placed in test section (2) The connectivity part of detectable substance (4), the sample-adding portion (1) and test section (2) is equipped with the inclined plane at a 48-55 degree angle, the inclination Reflectance coating polarizer is placed on face（5）.
- 2. biological culture microanalysis cuvette according to claim 1, it is characterised in that：Hold inside the test section (2) Amount volume is below 100 μ L, less than the internal capacity volume of sample-adding portion (1).
- 3. biological culture microanalysis cuvette according to claim 1, it is characterised in that：The inner side of the test section (2) Rough structure is used on wall, it is made of some grooves being intervally arranged, and prevents the bubble of liquid to detecting accuracy Impact.
- 4. biological culture microanalysis cuvette according to claim 1, it is characterised in that：The sample-adding portion (1) is upper end Be open direct sample addition type or reaction liquid closed rack method sample addition type.
- 5. biological culture microanalysis cuvette according to claim 4, it is characterised in that：The sample-adding portion (1) is reaction The structure that liquid closed racks method sample addition type is：The upper end is arranged a sealing ring slided up and down along sample-adding portion (1) upper end side wall (6), the interior reaction solution (3) for being equipped with closing of the sealing ring (6), a fixation is equipped with sample-adding portion (1) racks device (7), closing Easily to rack position below circle (6), when the sealing ring (6) is snapped down to lowest positions, racks device (7) and rack below sealing ring Easily rack position, reaction solution (3) is entered sample-adding portion (1), finally flow to test section (2).
- 6. biological culture microanalysis cuvette according to claim 1, it is characterised in that：The detected material (4) can be with For microbe carrier, enzyme, enzyme reaction thing, its carrier contain mode select water imbibition filter paper, can carrier liquid container, liquid dry freeze into Detection reagent is fixed on test section by the way of photocuring, and carrier liquid volume is between 10 μ L-100 μ L.
- 7. biological culture microanalysis cuvette according to claim 1, it is characterised in that：The sample-adding portion (1) and detection Portion (2) is using transparency, degree uniform in material, translucency and reflective are good, mould processes easily molded polypropylene, polyethylene, gathers Methymethacrylate, polycarbonate are made.
- 8. biological culture microanalysis cuvette according to claim 1, it is characterised in that：The incident light of the inclined plane shines Penetrate in the reflectance coating polarizer（5）On, reflected light is entered detected material (4), detected material（4）On send second of excitation Light.
- 9. biological culture microanalysis cuvette according to claim 8, it is characterised in that：The polarizer（5）For two to mirror, Sheet glass or plastic sheet.
- 10. biological culture microanalysis cuvette according to claim 8, it is characterised in that：The test section（2）It is equipped with loudspeaker Mouth (9), concentrates second of exciting light and is transmitted on receiver (8).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720938510.2U CN207232003U (en) | 2017-07-31 | 2017-07-31 | Biological culture microanalysis cuvette |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720938510.2U CN207232003U (en) | 2017-07-31 | 2017-07-31 | Biological culture microanalysis cuvette |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207232003U true CN207232003U (en) | 2018-04-13 |
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ID=61856044
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201720938510.2U Active CN207232003U (en) | 2017-07-31 | 2017-07-31 | Biological culture microanalysis cuvette |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN207232003U (en) |
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